Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.70
A. Sirotin, A. Krolevets, V. Klyueva, Nikita Lyakhovchenko, V. Senchenkov
The antibacterial activity of nanostructures based on antibiotics, plant extracts and metal salts against Escherichia.coli, Staphylococcus sp. and Aspergillus niger was shown. A statistically significant increase in the inhibition effect of ceftriaxone in the poludan was shown by 33,3%, copper sulfate in Na-CMC by 121,5-562,7% depending on the ratio of core:shell and suspension concentration, birch leaf extract in Na-alginate by 36,7-86,3%, in guar gum by 110,0484,5% compared with pure preparations. The inhibitory effect from nanostructured silver nitrate was not detected. The most effective ratios are core:shell 1:1 and 1:2. Keywords—nanostructured forms; antibiotics; plant extracts; metal salts; biocidal activity
{"title":"The study of the antibacterial and antimycotic activity of nanostructures based on antibiotics, plant extracts and salts metals","authors":"A. Sirotin, A. Krolevets, V. Klyueva, Nikita Lyakhovchenko, V. Senchenkov","doi":"10.2991/isils-19.2019.70","DOIUrl":"https://doi.org/10.2991/isils-19.2019.70","url":null,"abstract":"The antibacterial activity of nanostructures based on antibiotics, plant extracts and metal salts against Escherichia.coli, Staphylococcus sp. and Aspergillus niger was shown. A statistically significant increase in the inhibition effect of ceftriaxone in the poludan was shown by 33,3%, copper sulfate in Na-CMC by 121,5-562,7% depending on the ratio of core:shell and suspension concentration, birch leaf extract in Na-alginate by 36,7-86,3%, in guar gum by 110,0484,5% compared with pure preparations. The inhibitory effect from nanostructured silver nitrate was not detected. The most effective ratios are core:shell 1:1 and 1:2. Keywords—nanostructured forms; antibiotics; plant extracts; metal salts; biocidal activity","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82949215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.85
T. Vostrikova, O. Zemlyanukhina, V. Kalaev
—The study was made about parameters of fluctuating asymmetry of the birch leaf blade and amount of total soluble protein of the seed progeny of Betula pendula in areas of Central Black Earth Region in different environmental conditions. The environmental impact on trees of weeping birch and its seed progeny in areas with different ecological pressure was shown. The high level of fluctuating asymmetry was revealed in maternal samples growing in conditions of anthropogenic pressure. The seed progeny of Betula pendula has the increased amount of total protein in polluted areas as compared to the control group (maternal trees and its seed progeny collected in the ecologically clean territory).
{"title":"Amount of Total Protein and fluctuating asymmetry of Betula pendula in Various Ecological Conditions","authors":"T. Vostrikova, O. Zemlyanukhina, V. Kalaev","doi":"10.2991/isils-19.2019.85","DOIUrl":"https://doi.org/10.2991/isils-19.2019.85","url":null,"abstract":"—The study was made about parameters of fluctuating asymmetry of the birch leaf blade and amount of total soluble protein of the seed progeny of Betula pendula in areas of Central Black Earth Region in different environmental conditions. The environmental impact on trees of weeping birch and its seed progeny in areas with different ecological pressure was shown. The high level of fluctuating asymmetry was revealed in maternal samples growing in conditions of anthropogenic pressure. The seed progeny of Betula pendula has the increased amount of total protein in polluted areas as compared to the control group (maternal trees and its seed progeny collected in the ecologically clean territory).","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84191543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Belokurova, N. Sotnikov, A. Skrypnikov, S. Belokurov
This paper considers the possibility of intensification of biochemical processes, stabilization of biotechnological properties of semi-finished bakery products, in particular, liquid rye leaven and reduction of the production cycle by the introduction of biogenic plant raw materials, composition of herbal extracts (CELT), proposed formulations and modes of preparation of liquid rye leaven in the production cycle. A systematic analysis of changes in physical-chemical and microbiological parameters, as well as the processes occurring during the maturation of liquid rye leaven is carried out. It is established that the introduction of CELT into liquid leaven at a dose of 4% of the water mass intensifies the processes occurring during the fermentation of leaven. Keywords—system analysis, liquid rye starter, yeast colonies, lactic acid bacteria, physicochemical indicators, biogenic plant materials, herbal extracts compositions
{"title":"Systemic Analysis of the Stabilization of the Biotechnological Properties of Liquid Rye Leaven With the Introduction of Nutritious Plant Material","authors":"E. Belokurova, N. Sotnikov, A. Skrypnikov, S. Belokurov","doi":"10.2991/isils-19.2019.6","DOIUrl":"https://doi.org/10.2991/isils-19.2019.6","url":null,"abstract":"This paper considers the possibility of intensification of biochemical processes, stabilization of biotechnological properties of semi-finished bakery products, in particular, liquid rye leaven and reduction of the production cycle by the introduction of biogenic plant raw materials, composition of herbal extracts (CELT), proposed formulations and modes of preparation of liquid rye leaven in the production cycle. A systematic analysis of changes in physical-chemical and microbiological parameters, as well as the processes occurring during the maturation of liquid rye leaven is carried out. It is established that the introduction of CELT into liquid leaven at a dose of 4% of the water mass intensifies the processes occurring during the fermentation of leaven. Keywords—system analysis, liquid rye starter, yeast colonies, lactic acid bacteria, physicochemical indicators, biogenic plant materials, herbal extracts compositions","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86749923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.84
I. Volodin, A. Bezin, A. Miftakhutdinov, T. Shnyakina, Aleksandr Shudrik, S. Kontsevaya, Viktor Bezin
The paper dwells upon treatment of surgical sepsis in dogs by extracorporeal detoxification. Data were sampled from 32 dogs of various breeds, aged 4 to 12, weighing 20 to 68 kilogram, treated against surgical sepsis at the Panacea Veterinary Hospital, Chelyabinsk; the dogs were divided into the experimental group (17 dogs) and control group (15 dogs). In control dogs, the infection site was treated surgically by abdominal drainage in peritonitis, ovariohysterectomy in pyometra, etc., supported by infusion antibiotic therapy, vasopressor support, and treatment of comorbidities. Comprehensive treatment of the experimental group included 2 to 4 sessions of plasmapheresis with exfusion of 20% of the circulating plasma volume (CPV) and its replacement with Ringer and Refortan 6% solutions, 2 to 1, using Rosa-type plasma filters and a KMBP-01 machineless plasmapheresis complex. To that end, the experimenters studied such clinical readings as appetite, body temperature, heart rate (HR), respiratory rate (RR), capillary refill time (CRT), and skin turgor, as well as blood morphology and biochemistry. Plasmapheresis did not use perfusion pumps to minimize its effects on total hemodynamics. The study identified that combining a commonly accepted sepsis treatment method with 2 to 4 plasmapheresis sessions did reduce the mortality rates in the experimental group and boosted the animals’ recovery while also rapidly restoring the normal morphology and biochemistry of their blood. The team noted a significant increase in the total protein content, lower bilirubin, creatinine, and urea in the serum, which indicated recovered hepatic and renal functionality as a result of the comprehensive membrane plasmapheresis-enabled treatment of surgical sepsis in dogs. Keywords—dogs, sepsis, peritonitis, membrane plasmapheresis, total protein, bilirubin, creatinine
{"title":"Plasmapheresis for Comprehensive Treatment of Surgical Sepsis in Dogs","authors":"I. Volodin, A. Bezin, A. Miftakhutdinov, T. Shnyakina, Aleksandr Shudrik, S. Kontsevaya, Viktor Bezin","doi":"10.2991/isils-19.2019.84","DOIUrl":"https://doi.org/10.2991/isils-19.2019.84","url":null,"abstract":"The paper dwells upon treatment of surgical sepsis in dogs by extracorporeal detoxification. Data were sampled from 32 dogs of various breeds, aged 4 to 12, weighing 20 to 68 kilogram, treated against surgical sepsis at the Panacea Veterinary Hospital, Chelyabinsk; the dogs were divided into the experimental group (17 dogs) and control group (15 dogs). In control dogs, the infection site was treated surgically by abdominal drainage in peritonitis, ovariohysterectomy in pyometra, etc., supported by infusion antibiotic therapy, vasopressor support, and treatment of comorbidities. Comprehensive treatment of the experimental group included 2 to 4 sessions of plasmapheresis with exfusion of 20% of the circulating plasma volume (CPV) and its replacement with Ringer and Refortan 6% solutions, 2 to 1, using Rosa-type plasma filters and a KMBP-01 machineless plasmapheresis complex. To that end, the experimenters studied such clinical readings as appetite, body temperature, heart rate (HR), respiratory rate (RR), capillary refill time (CRT), and skin turgor, as well as blood morphology and biochemistry. Plasmapheresis did not use perfusion pumps to minimize its effects on total hemodynamics. The study identified that combining a commonly accepted sepsis treatment method with 2 to 4 plasmapheresis sessions did reduce the mortality rates in the experimental group and boosted the animals’ recovery while also rapidly restoring the normal morphology and biochemistry of their blood. The team noted a significant increase in the total protein content, lower bilirubin, creatinine, and urea in the serum, which indicated recovered hepatic and renal functionality as a result of the comprehensive membrane plasmapheresis-enabled treatment of surgical sepsis in dogs. Keywords—dogs, sepsis, peritonitis, membrane plasmapheresis, total protein, bilirubin, creatinine","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89553295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The root cause of premature culling of animals from the herd as a result of diseases and injuries is a lesion of distal portions of limbs of an infectious etiology, which include Mortellaro’s disease. Mortellaro's disease affects up to 60 percent of the cattle in Russia. BelNano was developed, consisting of liposomal fractions and nanoparticles of silver and copper distributed in its volume. The surface of the nanoparticles has been specially modified to provide high efficiency on the skin and keratinized tissues. Pathogens that were found in impression smear and Fusobacterium necrophorum, Treponema, Borellia grown on nutrient media, which were sensitive to the active components of the BelNANO, ensuring their inactivation by action on the cell wall were revealed in the studied animals with Motellaro's disease. In experiments on the study of effectiveness of the BelNANO for the prevention and treatment of skin and skin coverings of the distal portion of limbs in Mortellaro’s disease, 89 percent therapeutic efficacy was established, providing not only a high bactericidal and bacteriostatic effect on infectious agents, but also high regenerative properties of the drug, expressed in epithelization and the appearance of granulation tissue. Keywords—skin and skin lesions, Mortellaro’s disease, Cu and Ag nanoparticles, lameness, drug for the treatment of interdigital cleft, cattle
{"title":"Development of Drugs for Treatment of Mortellaro’s Disease in Cattle","authors":"N. Belyakova, A. Kovalenko, Yuliya Bodrova","doi":"10.2991/isils-19.2019.7","DOIUrl":"https://doi.org/10.2991/isils-19.2019.7","url":null,"abstract":"The root cause of premature culling of animals from the herd as a result of diseases and injuries is a lesion of distal portions of limbs of an infectious etiology, which include Mortellaro’s disease. Mortellaro's disease affects up to 60 percent of the cattle in Russia. BelNano was developed, consisting of liposomal fractions and nanoparticles of silver and copper distributed in its volume. The surface of the nanoparticles has been specially modified to provide high efficiency on the skin and keratinized tissues. Pathogens that were found in impression smear and Fusobacterium necrophorum, Treponema, Borellia grown on nutrient media, which were sensitive to the active components of the BelNANO, ensuring their inactivation by action on the cell wall were revealed in the studied animals with Motellaro's disease. In experiments on the study of effectiveness of the BelNANO for the prevention and treatment of skin and skin coverings of the distal portion of limbs in Mortellaro’s disease, 89 percent therapeutic efficacy was established, providing not only a high bactericidal and bacteriostatic effect on infectious agents, but also high regenerative properties of the drug, expressed in epithelization and the appearance of granulation tissue. Keywords—skin and skin lesions, Mortellaro’s disease, Cu and Ag nanoparticles, lameness, drug for the treatment of interdigital cleft, cattle","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75367924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.16
Taisiya Burginskaya, V. Deineka, I. Blinova, M. Tretiakov
New Russian F1 “Rubinovaya” cultivar of Daucus carota was found to be pink-colored due to biosynthesis of lycopene and β-carotene in relatively high overall level (up to 0.200 mg per 1 g of fresh weight, FW). The typical carotenoid composition of carrot roots with pink color were determined by proposed in the paper reversed-phase HPLC method. These are all-trans-lycopene (28 47 %); mixture of cis-lycopene isomers (7 – 10 %), all-trans-β-carotene (30 55%) and mixture of cis-β-carotene isomers (7 – 10 %). From chromatographic point of view carotenoids are retained in the proposed conditions by distribution mechanism due to a long chain of conjugated C=C-bonds makes this part of carotenoids planar with ability penetrate space between grafted C18 chains. Keywords—Daucus carota, R1 ”Rubinovaya” cultivar, lycopene, β-carotene, RP HPLC, distribution mechanism of retention formatting, style, styling, insert
{"title":"Carotenoids of a New Russian Carrot Cultivar F1 “Rubinovaya”","authors":"Taisiya Burginskaya, V. Deineka, I. Blinova, M. Tretiakov","doi":"10.2991/isils-19.2019.16","DOIUrl":"https://doi.org/10.2991/isils-19.2019.16","url":null,"abstract":"New Russian F1 “Rubinovaya” cultivar of Daucus carota was found to be pink-colored due to biosynthesis of lycopene and β-carotene in relatively high overall level (up to 0.200 mg per 1 g of fresh weight, FW). The typical carotenoid composition of carrot roots with pink color were determined by proposed in the paper reversed-phase HPLC method. These are all-trans-lycopene (28 47 %); mixture of cis-lycopene isomers (7 – 10 %), all-trans-β-carotene (30 55%) and mixture of cis-β-carotene isomers (7 – 10 %). From chromatographic point of view carotenoids are retained in the proposed conditions by distribution mechanism due to a long chain of conjugated C=C-bonds makes this part of carotenoids planar with ability penetrate space between grafted C18 chains. Keywords—Daucus carota, R1 ”Rubinovaya” cultivar, lycopene, β-carotene, RP HPLC, distribution mechanism of retention formatting, style, styling, insert","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78170764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.72
E. Snegin, Anatoliy S. Barkhatov, E. Snegina
On the basis of SSR-method the genetic structure of marsh frog populations (Pelophylax ridibundus) in the urbanized area of Belgorod and its suburbs was studied. The data obtained indicate a high level of genetic variability in the populations studied. The heterozygosity level was equal to He=0.731±0.027, Ho=0.587±0.037, Shannon index I=1.737±0.082, and the effective number of alleles Ae=4.992±0.364. However, in a number of populations there is a trend towards a decrease in genetic diversity and an increase in the level of inbreeding. Keywords—Pelophylax ridibundus, SSR, population, urbanized area
{"title":"Analysis of the Genetic Structure of the Populations of Marsh Frog (Pelophylax Ridibundus) in the Impact Territories of the City of Belgorod on the Basis of Microsatellite Markers of DNA","authors":"E. Snegin, Anatoliy S. Barkhatov, E. Snegina","doi":"10.2991/isils-19.2019.72","DOIUrl":"https://doi.org/10.2991/isils-19.2019.72","url":null,"abstract":"On the basis of SSR-method the genetic structure of marsh frog populations (Pelophylax ridibundus) in the urbanized area of Belgorod and its suburbs was studied. The data obtained indicate a high level of genetic variability in the populations studied. The heterozygosity level was equal to He=0.731±0.027, Ho=0.587±0.037, Shannon index I=1.737±0.082, and the effective number of alleles Ae=4.992±0.364. However, in a number of populations there is a trend towards a decrease in genetic diversity and an increase in the level of inbreeding. Keywords—Pelophylax ridibundus, SSR, population, urbanized area","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74390343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.10
A. Bondarev, E. Zhilyakova, N. Bondareva, D. Fadeeva
—The aim of the work is to develop classification and systematics of Medical Clays. Tasks: to conduct screening marketing study of the pharmaceutical market of medical clays in Russia and neighboring countries; to develop classification and systematics of Medical Clays with their characteristics. The materials are electronic resources eLIBRARY, Russian Drug Register, own research results also. The methods are analysis and classification. Results. Conducted a screening marketing study of the pharmaceutical market of Medical Clays. It was established that at present in Russia there is one pharmaceutical substance of Medical Clay “Smectite Dioctahedral”; 8 drugs based on Dioctahedral Smectite are registered: 3 of them are made on the basis of domestic substances, 1 - made in France, 1 - made in the USA, 2 - made in China. The classification and systematics of Medical Clays has been developed, according to which Medical Clays are represented by three groups that determine their sorption properties: Palygorskite, Smectite and Kaolinite Clays. The atomic structure of the main minerals of Medical Clays is composed of two units: octahedral and Silicon-Oxygen tetrahedral. Medical Clays consisting of Montmorillonite and Kaolinite minerals have two types of pores; the specific surface area is higher for clays consisting of Montmorillonite and Palygorskite minerals; the cation exchange capacity is higher for the Montmorillonite mineral. Conclusion. The classification and systematics of Medical Clays has been developed, according to which Medical Clays are represented by three groups that determine their sorption properties: Palygorskite, Smectite and Kaolinite Clays.
{"title":"Classification and Systematics of Medical Clay","authors":"A. Bondarev, E. Zhilyakova, N. Bondareva, D. Fadeeva","doi":"10.2991/isils-19.2019.10","DOIUrl":"https://doi.org/10.2991/isils-19.2019.10","url":null,"abstract":"—The aim of the work is to develop classification and systematics of Medical Clays. Tasks: to conduct screening marketing study of the pharmaceutical market of medical clays in Russia and neighboring countries; to develop classification and systematics of Medical Clays with their characteristics. The materials are electronic resources eLIBRARY, Russian Drug Register, own research results also. The methods are analysis and classification. Results. Conducted a screening marketing study of the pharmaceutical market of Medical Clays. It was established that at present in Russia there is one pharmaceutical substance of Medical Clay “Smectite Dioctahedral”; 8 drugs based on Dioctahedral Smectite are registered: 3 of them are made on the basis of domestic substances, 1 - made in France, 1 - made in the USA, 2 - made in China. The classification and systematics of Medical Clays has been developed, according to which Medical Clays are represented by three groups that determine their sorption properties: Palygorskite, Smectite and Kaolinite Clays. The atomic structure of the main minerals of Medical Clays is composed of two units: octahedral and Silicon-Oxygen tetrahedral. Medical Clays consisting of Montmorillonite and Kaolinite minerals have two types of pores; the specific surface area is higher for clays consisting of Montmorillonite and Palygorskite minerals; the cation exchange capacity is higher for the Montmorillonite mineral. Conclusion. The classification and systematics of Medical Clays has been developed, according to which Medical Clays are represented by three groups that determine their sorption properties: Palygorskite, Smectite and Kaolinite Clays.","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81029115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-01DOI: 10.2991/isils-19.2019.43
I. Krasnyuk, V. Grikh, A. Belyatskaya, O. I. Stepanova, V. Beketov, Galina Varenykh
A method has been developed for obtaining samples of a derivative of 1,4-dihydropyridine-nifedipine gels using the solid dispersion technique. A quality assessment of the obtained soft dosage forms has been performed. The effectiveness of the proposed technique for obtaining nifedipine gels has been proved, which makes it possible to increase the pharmaceutical availability of the poorly water soluble investigational substance, providing better release by increasing its solubility and dissolution rate. Keywords—nifedipine, solid dispersions, gel,
{"title":"Development of a Derivative of 1,4-Dihydropyridine Gels Using Solid Dispersion Technique","authors":"I. Krasnyuk, V. Grikh, A. Belyatskaya, O. I. Stepanova, V. Beketov, Galina Varenykh","doi":"10.2991/isils-19.2019.43","DOIUrl":"https://doi.org/10.2991/isils-19.2019.43","url":null,"abstract":"A method has been developed for obtaining samples of a derivative of 1,4-dihydropyridine-nifedipine gels using the solid dispersion technique. A quality assessment of the obtained soft dosage forms has been performed. The effectiveness of the proposed technique for obtaining nifedipine gels has been proved, which makes it possible to increase the pharmaceutical availability of the poorly water soluble investigational substance, providing better release by increasing its solubility and dissolution rate. Keywords—nifedipine, solid dispersions, gel,","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91520720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Birukova, D. Zima, E. Zyablitskaya, O. Bezrukov, T. Makalish, L. Shaymardanova
The article is devoted to the study of indicators of the cardiorespiratory system in rats of different sexes under conditions of chronic hypokinetic stress (HK), on the background of normal nutrition, and also in conditions of longterm restricted nutrition (RN). It was shown that the 21-day exposure to hypokinetic stress, both with a normal type of diet and in conditions of long-term restricted nutrition, has an evident effect on the indicators of the cardiorespiratory system in laboratory animals, which is expressed in the increase of the heart rate on the background of the decreased respiratory rate and depth, and also the decrease in the percentage of oxygen in the rats blood, both males and females.
{"title":"The indicators of cardiorespiratory system in rats in conditions of chronic hypokinetic stress on the background of normal and restricted nutrition","authors":"E. Birukova, D. Zima, E. Zyablitskaya, O. Bezrukov, T. Makalish, L. Shaymardanova","doi":"10.2991/isils-19.2019.8","DOIUrl":"https://doi.org/10.2991/isils-19.2019.8","url":null,"abstract":"The article is devoted to the study of indicators of the cardiorespiratory system in rats of different sexes under conditions of chronic hypokinetic stress (HK), on the background of normal nutrition, and also in conditions of longterm restricted nutrition (RN). It was shown that the 21-day exposure to hypokinetic stress, both with a normal type of diet and in conditions of long-term restricted nutrition, has an evident effect on the indicators of the cardiorespiratory system in laboratory animals, which is expressed in the increase of the heart rate on the background of the decreased respiratory rate and depth, and also the decrease in the percentage of oxygen in the rats blood, both males and females.","PeriodicalId":20489,"journal":{"name":"Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81007498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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