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Production and evaluation of the polyester composites containing pyrite and niobium diboride for radiation protection 生产和评估含黄铁矿和二硼化铌的聚酯复合材料,用于辐射防护
IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL Pub Date : 2024-10-16 DOI: 10.1016/j.radphyschem.2024.112326
Ferdi Akman , Mehmet Fatih Turhan , Hasan Oğul , Ahmet Turşucu , Taha Erdoğan , Mustafa Recep Kaçal , Hasan Polat
The presented study focused on investigating the radiation shielding properties of polyester/pyrite/niobium diboride (FeSNbB) composites. Various gamma-ray shielding parameters were evaluated with help of a HPGe detector system. Theoretical and simulation results are further evaluated by WinXCOM, GEANT4 and FLUKA codes, and the obtained results are compared with experimental values in the energy region 59.5 keV–1332.5 keV. The prepared samples are additionally evaluated using kerma relative to air values and Exposure build-up factors. Then, for the evaluation of neutron radiation shielding, effective removal cross sections for fast neutrons were determined for FeSNbB composites. Electron attenuation efficiency (AE%) for the produced composites was assessed across the energy spectrum of 4 MeV–18 MeV, utilizing experimental data from a Linac machine and theoretical predictions from Eclipse TPS. The results were found to be compatible with each other. FeSNbB50 has the best shielding properties among the studied composites.
本研究的重点是调查聚酯/黄铁矿/二硼化铋铌(FeSNbB)复合材料的辐射屏蔽性能。在 HPGe 探测器系统的帮助下,对各种伽马射线屏蔽参数进行了评估。理论和模拟结果通过 WinXCOM、GEANT4 和 FLUKA 代码进行了进一步评估,并将所得结果与 59.5 keV-1332.5 keV 能量区域的实验值进行了比较。此外,还使用相对于空气的 kerma 值和暴露堆积因子对制备的样品进行了评估。然后,为了评估中子辐射屏蔽,确定了铁硒铌复合材料对快中子的有效清除截面。利用 Linac 机器的实验数据和 Eclipse TPS 的理论预测,评估了所生产复合材料在 4 MeV-18 MeV 能谱范围内的电子衰减效率(AE%)。结果发现两者是一致的。在所研究的复合材料中,FeSNbB50 的屏蔽性能最好。
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引用次数: 0
An SSDLs calibration method for the kerma-area product meter 用于热辐射积算仪的 SSDLs 校准方法
IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL Pub Date : 2024-10-15 DOI: 10.1016/j.radphyschem.2024.112299
Qian Yang, Shimeng Xu, Jie Fan
The kerma-area product meter (KAP meter) is mainly used for quality assurance in medical imaging research, providing dose quality assessment or dose monitoring for patients. It can be calibrated either in the laboratory or on-site. The purpose of this study is to propose a method for calibrating the KAP meter using a plane-parallel transmission ionization chamber in the SSDLs. In the range of 50 kV–150 kV, under RQR (standard radiation qualities) and RQR additional filtering conditions of the KAP meter, the correction factor NQm of the transmission ionization chamber is calculated to select two types of KAP meters for the calibration of the transmitted beam. The collimators used to limit the size of the radiation field are respectively 50.07 mm in length, 30.03 mm in length, and 20.05 mm in radius. This method, with uncertainty not exceeding 3.0% while improving calibration efficiency, can replace the unit-specific correction of the laboratory method (Toroi et al., 2008).
KAP 计主要用于医学成像研究的质量保证,为患者提供剂量质量评估或剂量监测。它可以在实验室或现场进行校准。本研究的目的是提出一种在 SSDL 中使用平面平行透射电离室校准 KAP 计的方法。在 50 kV-150 kV 范围内,在 KAP 计的 RQR(标准辐射质量)和 RQR 附加滤波条件下,计算透射电离室的校正系数 NQm,以选择两种类型的 KAP 计对透射光束进行校准。用于限制辐射场大小的准直器长度分别为 50.07 毫米、30.03 毫米和 20.05 毫米。这种方法的不确定性不超过 3.0%,同时提高了校准效率,可以取代实验室方法的特定单位校正(Toroi 等人,2008 年)。
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引用次数: 0
Nanostructures for cancer therapeutics and diagnostics: Recent advances and future outlook 用于癌症治疗和诊断的纳米结构:最新进展与未来展望
IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL Pub Date : 2024-10-15 DOI: 10.1016/j.radphyschem.2024.112295
Seifeldin Elabed, Abdelrahman Sheirf, M. Ali
Nanotechnology holds tremendous promise for advancing cancer treatment and imaging. Various nanostructures, including liposomes, polymersomes, dendrimers, carbon nanotubes, mesoporous silica nanoparticles, and metal nanoparticles, have been extensively investigated for applications such as targeted drug delivery, thermal ablation, gene therapy, MRI contrast enhancement, fluorescence imaging, theranostics, and photoacoustic imaging. This review offers a systematic evaluation of recent advancements in nanostructure applications for cancer, covering studies from 2018 to 2023. A thorough literature searches across major databases yielded over 500 relevant studies. Key insights demonstrate improved anticancer efficacy, site-specific accumulation, reduced toxicity, and real-time therapeutic response monitoring through the use of optimized multifunctional nanostructures in preclinical cancer models. However, the majority of these nanostructures remain in preclinical or early clinical stages. Addressing critical challenges related to pharmacokinetics, tumor penetration, biocompatibility, clearance, and toxicity through detailed mechanistic studies and assessments is essential for clinical translation. Future advancements in bioinspired designs, surface modifications, combination therapies, stimuli-responsive systems, in situ activation, multimodal imaging, and integration with emerging technologies such as microfluidics and AI could significantly accelerate the clinical success of nanotherapeutics, paving the way for precise and personalized cancer care. Ultimately, this review underscores the transformative potential of nanostructures in cancer treatment and diagnostics, while highlighting the necessity of integrated and rigorous optimization to achieve breakthrough outcomes in clinical oncology.
纳米技术在推动癌症治疗和成像方面前景广阔。各种纳米结构,包括脂质体、聚合物体、树枝状聚合物、碳纳米管、介孔二氧化硅纳米颗粒和金属纳米颗粒,已被广泛研究用于靶向给药、热消融、基因治疗、核磁共振成像对比度增强、荧光成像、治疗学和光声成像等应用。本综述系统评估了纳米结构在癌症应用方面的最新进展,涵盖 2018 年至 2023 年的研究。通过对主要数据库进行全面的文献检索,共获得 500 多项相关研究。主要见解表明,通过在临床前癌症模型中使用优化的多功能纳米结构,抗癌疗效、特定位点积累、毒性降低和实时治疗反应监测均有所改善。然而,这些纳米结构大多仍处于临床前或早期临床阶段。通过详细的机理研究和评估,解决与药代动力学、肿瘤渗透、生物相容性、清除和毒性相关的关键挑战,对于临床转化至关重要。未来在生物启发设计、表面修饰、联合疗法、刺激响应系统、原位激活、多模态成像以及与微流控和人工智能等新兴技术的整合方面取得的进展,将大大加快纳米疗法在临床上取得成功的速度,为精确和个性化的癌症治疗铺平道路。最后,这篇综述强调了纳米结构在癌症治疗和诊断中的变革潜力,同时强调了综合和严格优化的必要性,以便在临床肿瘤学中取得突破性成果。
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引用次数: 0
Gamma attenuation and radiation shielding performance of CaCu3B2Re2O12 (BMn, Fe, Co, and Ni) perovskites CaCu3B2Re2O12(BMn、Fe、Co 和 Ni)包晶的伽马衰减和辐射屏蔽性能
IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL Pub Date : 2024-10-15 DOI: 10.1016/j.radphyschem.2024.112292
B. Alshahrani , Jamila S. Alzahrani , Amani Alalawi , Sultan Alomairy , I.O. Olarinoye , M.S. Al-Buriahi
In order to identify the importance of perovskites in nuclear science, studies aimed at obtaining the radiation interaction quantities of perovskites are essential. This study computed and analyzed the gamma photon interaction parameters of CaCu3B2Re2O12 (BMn, Fe, Co, and Ni) perovskites to reveal their shielding potentials and comparative advantages against traditional shielding materials. Four samples of ferrimagnetic quaternary perovskites whose chemical structures are summarized as CaCu3B2Re2O12 (BMn (CCMRO1), Fe (CCMRO2), Co (CCMRO3), and Ni (CCMRO4)) were considered for their gamma interaction quantities. The values of mass attenuation coefficient (μρ) was calculated with XCOM and they were in the range of 0.0552 cm2/g–0.4162 cm2/g for CCMRO1, 0.0553 cm2/g–0.4165 cm2/g CCMRO2, 0.0552 cm2/g–0.4148 cm2/g for CCMRO3, and 0.0555 cm2/g–0.4163 cm2/g for CCMRO4. The values of effective atomic number and electron density was within the range 21.38–43.38 and 2.84 x 1023 electrons/g −5.62 x1023 electrons/g, respectively. The trend of the mass energy absorption coefficients of the perovskites was also found to be in the same order as the mass attenuation coefficient. CCMRO3 has the highest photon energy absorptive ability among the perovskites while CCMRO2 has the least capacity. Also, the gamma dose rates in15 mm thick of CCMRO1, CCMRO2, CCMRO3, and CCMRO4 for 1.25 MeV are about 1446 kR/h, 1449 kR/h, 1453 kR/h, and 1446 kR/h, respectively. Comparatively, the values of the exposure and energy absorption buildup factors were almost the same for the perovskites at the same energy and optical depth. The investigated perovskites had higher mass attenuation coefficients that standard shielding glasses. The perovskites can be used for shielding or any other radiation absorption roles in radiation science and technology, especially for photons at low energies.
为了确定包晶在核科学中的重要性,必须开展旨在获得包晶辐射相互作用量的研究。本研究计算并分析了 CaCu3B2Re2O12(BMn、Fe、Co 和 Ni)包晶的伽马光子相互作用参数,以揭示其屏蔽潜力以及与传统屏蔽材料的比较优势。研究考虑了化学结构概括为 CaCu3B2Re2O12(BMn(CCMRO1)、Fe(CCMRO2)、Co(CCMRO3)和 Ni(CCMRO4))的四种铁磁性四元包晶石样品的伽马相互作用量。质量衰减系数(μρ)由 XCOM 计算得出,CCMRO1 为 0.0552 cm2/g-0.4162 cm2/g,CCMRO2 为 0.0553 cm2/g-0.4165 cm2/g,CCMRO3 为 0.0552 cm2/g-0.4148 cm2/g,CCMRO4 为 0.0555 cm2/g-0.4163 cm2/g。有效原子序数和电子密度值分别在 21.38-43.38 和 2.84 x 1023 电子/克-5.62 x 1023 电子/克范围内。研究还发现,包覆晶的质量能量吸收系数的变化趋势与质量衰减系数的变化趋势相同。其中,CCMRO3 的光子能量吸收能力最强,而 CCMRO2 的吸收能力最小。此外,在 1.25 MeV 下,CCMRO1、CCMRO2、CCMRO3 和 CCMRO4 在 15 毫米厚的伽马剂量率分别约为 1446 kR/h、1449 kR/h、1453 kR/h 和 1446 kR/h。相比之下,在相同的能量和光学深度下,包晶的曝光和能量吸收积累因子值几乎相同。与标准屏蔽玻璃相比,所研究的包晶具有更高的质量衰减系数。这种过氧化物可用于屏蔽或辐射科学与技术中的任何其他辐射吸收作用,特别是对低能量光子。
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引用次数: 0
Enhance optically stimulated luminescence sensitivity and improve fading of newly developed LiMgPO4:Er phosphor 提高新开发的 LiMgPO4:Er 荧光粉的光激发发光灵敏度并改善褪色情况
IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL Pub Date : 2024-10-15 DOI: 10.1016/j.radphyschem.2024.112297
Kaiyong Tang , Li Fu , Siyuan Zhang , Mo Zhou , Haijun Fan , Yan Zeng
To avoid fading, the readout time of the old LiMgPO4:Er in the previous study had to be taken to be at least 20 s. The readout time is up to 20 s, which not only contradicts the fast OSL readout, but also eliminates too many OSL signals per readout and is not favourable to the requirement that the OSL can be read multiple times. The primary objective of this study is to reduce readout time under conditions where the OSL signal of LiMgPO4:Er phosphor stabilizes after irradiation. The OSL properties were investigated. To achieve OSL fading of about 5% within 30 d after irradiation, the shortest integration time for new LiMgPO4:Er in this study was 1 s, whereas old LiMgPO4:Er required 20 s. When the integration time was 1 s, the OSL sensitivity of the new LiMgPO4:Er samples in this study was about 2.4 times that of the old LiMgPO4:Er samples. A new LiMgPO4:Er phosphor with an OSL signal loss of about 5% for the shortest integration time of 1 s within 30 days after irradiation, a sensitivity comparable to that of TLD-500k, and an MMD as low as 38 μGy was successfully prepared, which will meet the fast read out and the multiple readings requirements.
为了避免衰减,之前研究中旧的 LiMgPO4:Er 的读出时间必须至少达到 20 秒。读出时间长达 20 秒,这不仅与快速 OSL 读出相矛盾,而且每次读出会消除过多的 OSL 信号,不利于 OSL 可以多次读出的要求。本研究的主要目的是在锂镁磷酸盐:铒荧光粉的 OSL 信号在辐照后趋于稳定的条件下缩短读出时间。对 OSL 特性进行了研究。为了在辐照后 30 d 内使 OSL 衰减约为 5%,本研究中新 LiMgPO4:Er 的最短积分时间为 1 s,而旧 LiMgPO4:Er 则需要 20 s。当积分时间为 1 s 时,本研究中新 LiMgPO4:Er 样品的 OSL 灵敏度约为旧 LiMgPO4:Er 样品的 2.4 倍。成功制备了一种新的 LiMgPO4:Er 荧光粉,在辐照后 30 天内,最短积分时间为 1 秒时,OSL 信号损失约为 5%,灵敏度与 TLD-500k 相当,MMD 低至 38 μGy,可满足快速读出和多次读取的要求。
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引用次数: 0
Zinc boro-aluminosilicate glass for infrared and gamma sensing applications: Physical properties and gamma ray attenuation aspects 用于红外和伽马传感应用的硼铝硅酸锌玻璃:物理特性和伽马射线衰减方面的问题
IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL Pub Date : 2024-10-15 DOI: 10.1016/j.radphyschem.2024.112293
Yahaya Saadu Itas , Mayeen Uddin Khandaker , Aliyu Mohammed Aliyu , Ali Shawabkeh , Afsar khan , Abdulrahman A. Almehizia
The demand for more materials for efficient shielding of radiation has been on the rise day by day due to some witnessed progress in applications of radiations in science and technology. In this research, we investigated the gamma ray shielding capacity of zinc boro-aluminosilicate (ZBASi) glass by varying concentrations of B2O3. Fundamentally, experimental and theoretical means were both adopted to evaluate photon shielding characteristics of the studied glasses. Additionally, amorphous nature and crystalline sizes of the glass sample were determined using XRD technique and Debye Scherrer equation respectively. The results show that as the B2O3 content increased from 55 to 70 wt %, the optical bandgap, and packing density decreased. However, the density, and molar volume were found to increase accordingly. Using Phy-x/PSD and genat4, the maximum values of mass attenuation coefficient (MAC) for ZBASi-4, ZBASi-3, ZBASi-2, and ZBASi-1 were found to be 20.2, 17.5, 16.3, and 9.6 cm2/g at 20 KeV, respectively. With respect to exposure rate, the exposure buildup factor (EBF) is low in the region where density is high, meaning that photon attenuation power is high in the region of low EFB (high density). The production of aluminosilicate glass poses fewer environmental risks than that of traditional lead-based shielding materials. It is therefore a more environmentally friendly option since harmful heavy metals are not involved.
由于辐射在科技领域的应用取得了一些有目共睹的进展,对更多有效屏蔽辐射的材料的需求与日俱增。在这项研究中,我们研究了不同浓度的 B2O3 对硼铝硅酸锌(ZBASi)玻璃的伽马射线屏蔽能力。从根本上说,我们采用了实验和理论两种方法来评估所研究玻璃的光子屏蔽特性。此外,还利用 XRD 技术和 Debye Scherrer 方程分别测定了玻璃样品的无定形性质和结晶尺寸。结果表明,随着 B2O3 含量从 55 wt % 增加到 70 wt %,光带隙和堆积密度都有所下降。然而,密度和摩尔体积却相应增加。使用 Phy-x/PSD 和 genat4,发现 ZBASi-4、ZBASi-3、ZBASi-2 和 ZBASi-1 在 20 KeV 时的质量衰减系数 (MAC) 最大值分别为 20.2、17.5、16.3 和 9.6 cm2/g。就曝光率而言,在密度高的区域,曝光堆积因子(EBF)较低,这意味着在低 EFB(高密度)区域,光子衰减功率较高。与传统的铅基屏蔽材料相比,硅酸铝玻璃的生产对环境造成的风险更小。因此,由于不涉及有害重金属,它是一种更环保的选择。
{"title":"Zinc boro-aluminosilicate glass for infrared and gamma sensing applications: Physical properties and gamma ray attenuation aspects","authors":"Yahaya Saadu Itas ,&nbsp;Mayeen Uddin Khandaker ,&nbsp;Aliyu Mohammed Aliyu ,&nbsp;Ali Shawabkeh ,&nbsp;Afsar khan ,&nbsp;Abdulrahman A. Almehizia","doi":"10.1016/j.radphyschem.2024.112293","DOIUrl":"10.1016/j.radphyschem.2024.112293","url":null,"abstract":"<div><div>The demand for more materials for efficient shielding of radiation has been on the rise day by day due to some witnessed progress in applications of radiations in science and technology. In this research, we investigated the gamma ray shielding capacity of zinc boro-aluminosilicate (ZBASi) glass by varying concentrations of B<sub>2</sub>O<sub>3</sub>. Fundamentally, experimental and theoretical means were both adopted to evaluate photon shielding characteristics of the studied glasses. Additionally, amorphous nature and crystalline sizes of the glass sample were determined using XRD technique and Debye Scherrer equation respectively. The results show that as the B<sub>2</sub>O<sub>3</sub> content increased from 55 to 70 wt %, the optical bandgap, and packing density decreased. However, the density, and molar volume were found to increase accordingly. Using Phy-x/PSD and genat4, the maximum values of mass attenuation coefficient (MAC) for ZBASi-4, ZBASi-3, ZBASi-2, and ZBASi-1 were found to be 20.2, 17.5, 16.3, and 9.6 cm<sup>2</sup>/g at 20 KeV, respectively. With respect to exposure rate, the exposure buildup factor (EBF) is low in the region where density is high, meaning that photon attenuation power is high in the region of low EFB (high density). The production of aluminosilicate glass poses fewer environmental risks than that of traditional lead-based shielding materials. It is therefore a more environmentally friendly option since harmful heavy metals are not involved.</div></div>","PeriodicalId":20861,"journal":{"name":"Radiation Physics and Chemistry","volume":"226 ","pages":"Article 112293"},"PeriodicalIF":2.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the cross section data for cyclotron production of medical radionuclides 201Pb→201Tl and 203Pb 评估回旋加速器生产医用放射性核素 201Pb→201Tl 和 203Pb 的截面数据
IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL Pub Date : 2024-10-15 DOI: 10.1016/j.radphyschem.2024.112294
Samar , N. Amjed , A. Naz , A.M. Wajid , M. Eman , M.A. Saeed
Lead Isotopes can be effectively used in nuclear medicine, 203Pb forms a theranostic pair with 212Pb whereas 201Pb→ 201Tl, facilitate the production of 201Tl via the generator system. The aim of this work was to achieve the high purity production of 203Pb and 201Tl via a cyclotron. To achieve this, several charged particle induced reactions namely 205Tl(p,3n)203Pb, 205Tl(d,4n)203Pb, 205Tl(p,5n)201Pb→201Tl, 205Tl(d,6n)201Pb→201Tl, 203Tl(p,3n)201Pb→201Tl, and 203Tl(d,4n)201Pb→201Tl were evaluated. First the consistency and reliability of the experimental data were ensured by using established nuclear model codes like TALYS 1.9 and EMPIRE 3.2. A robust methodology, based on experimental data and theoretical nuclear models, was used to generate the recommended cross sections for each production route and associated radioisotopic impurities. The thick target yields were calculated for each production route and its corresponding impurity reaction by utilizing the recommended/reference data. Following a thorough analysis and comparison of the evaluated production routes, it was concluded that the most promising options are 205Tl(d,4n)203Pb and 203Tl(p,3n)201Pb→201Tl. Their optimum conditions were determined as Ed = 30 → 21 MeV and Ep = 30 → 21 MeV with integral yields of 568.9 MBq/μAh and 1223.5 MBq/μAh respectively.
铅同位素可有效地用于核医学,203Pb 与 212Pb 形成放射对,而 201Pb→ 201Tl,通过发生器系统生产 201Tl。这项工作的目的是通过回旋加速器实现 203Pb 和 201Tl 的高纯度生产。为此,我们评估了几种带电粒子诱导反应,即 205Tl(p,3n)203Pb、205Tl(d,4n)203Pb、205Tl(p,5n)201Pb→201Tl、205Tl(d,6n)201Pb→201Tl、203Tl(p,3n)201Pb→201Tl 和 203Tl(d,4n)201Pb→201Tl。首先,通过使用 TALYS 1.9 和 EMPIRE 3.2 等成熟的核模型代码,确保了实验数据的一致性和可靠性。在实验数据和理论核模型的基础上,采用一种稳健的方法为每种生产途径和相关的放射性同位素杂质生成推荐的截面。利用推荐/参考数据计算了每种生产途径及其相应杂质反应的厚目标产率。在对所评估的生产路线进行全面分析和比较之后,得出的结论是最有前途的选择是 205Tl(d,4n)203Pb 和 203Tl(p,3n)201Pb→201Tl。它们的最佳条件被确定为 Ed = 30 → 21 MeV 和 Ep = 30 → 21 MeV,积分产量分别为 568.9 MBq/μAh 和 1223.5 MBq/μAh。
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引用次数: 0
Study of natB(3He, p) reactions cross sections using a novel setup for 3He-NRA micro analyses 利用新型 3He-NRA 显微分析装置研究 natB(3He,p)反应截面
IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL Pub Date : 2024-10-15 DOI: 10.1016/j.radphyschem.2024.112298
Toni Dunatov , Georgios Provatas , Stjepko Fazinić , Varvara Foteinou , Fotios Maragkos , Karla Ivanković Nizić , Maja Mičetić
In the present work experimentally determined differential cross sections of the reactions 10B(3He, p1,3)12C, 11B(3He, p0,1,2,3)13C and 11B(3He, d0)12C are reported. The measurements cover the 2–3 MeV energy range, for 5 detection angles of θ = 137°, 141°, 146°, 152°, 158°. A novel experimental setup was designed for this purpose and installed at the Dual Microprobe end-station of the Ruđer Bošković Institute (RBI) in Zagreb, Croatia. It involves an annular strip charged particle silicon detector with a large solid angle, enabling a relatively fast acquisition process without significant increase in the angular uncertainty. The obtained cross sections were benchmarked with a thick amorphous boron target in a different experimental setup at RBI, as well as at the scattering chamber setup of the RUBION accelerator facility in Bochum, Germany.
本研究报告了实验测定的 10B(3He,p1,3)12C、11B(3He,p0,1,2,3)13C 和 11B(3He,d0)12C 反应的微分截面。测量覆盖 2-3 MeV 能量范围,5 个探测角分别为 θ = 137°、141°、146°、152°、158°。为此设计了一个新颖的实验装置,安装在克罗地亚萨格勒布鲁德尔-博什科维奇研究所(RBI)的双微探针终端站。它包括一个环形带电粒子硅探测器,具有较大的固角,能够在不显著增加角度不确定性的情况下实现相对较快的采集过程。所获得的横截面以 RBI 的不同实验装置中的厚无定形硼靶以及德国波鸿 RUBION 加速器设施的散射室装置为基准。
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引用次数: 0
Application of phase space file secondary computation method in cell dose distribution 相空间文件二次计算法在细胞剂量分配中的应用
IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL Pub Date : 2024-10-15 DOI: 10.1016/j.radphyschem.2024.112301
Jiahao Guo , Xinlei Li , Yidi Wang, Han Gao, Xianghui Kong, Tao Wu, Xinjie Wang, Kaijin Yan, WenYue Zhang, YuChen Yin, Jianping Cao, Yang Jiao, Liang Sun
Phase space files can store the particle information in one or more planes of radiation particles simulated by the Monte Carlo (MC) method. The secondary calculation method based on phase space files is commonly used to improve the efficiency of MC simulations. However, it is still unclear whether phase space files are applicable for microdosimetric evaluations. In this study, voxel-type and mesh-type monolayer cell population models of different sizes were constructed, and phase space files of secondary electrons generated by photons with different initial energies were obtained using the MC software -- PHITS. The overall average dose caused by the secondary electron phase space files in the region of interest and their microdosimetric distribution within cells were calculated and compared with the results caused by the initial photons under the same geometric conditions. The results showed that the adoption of secondary electron phase space files had almost no impact on the evaluation of macroscopic average dose, with deviations lower than 3% compared to the overall dose caused by the initial photons in the Petri dish. For microdosimetric distributions of the voxel-type model and the two different morphologies of mesh-type cell models, with a macroscopic accumulated dose of 1 mGy, the relative deviation of the cell dose distribution generated by the initial photons and the phase space files was below 10% and the total computation time of phase space files was below 2% of initial photon's. For accumulated doses of 10, 50, and 100 mGy, the relative deviation of the cell nucleus specific energy obtained by secondary electrons and initial photons was greater than 10%. As the size of the culture dish increased, the differences in cell dose distributions also increased, with the root mean square error (RMSE) and coefficient of variation (Cv) of dose distributions both exceeding 30%. In conclusion, this study assessed the effectiveness of the secondary calculation method utilizing phase space files for dose evaluation at the cellular scale. This research offers essential technical support and theoretical foundations for the utilization of this approach in microdosimetric investigations at the cellular level.
相空间文件可以存储用蒙特卡罗(MC)方法模拟的辐射粒子的一个或多个平面的粒子信息。基于相空间文件的二次计算方法通常用于提高 MC 模拟的效率。然而,相空间文件是否适用于微剂量测定评估仍不清楚。本研究构建了不同大小的体素型和网格型单层细胞群模型,并利用 MC 软件 PHITS 获得了不同初始能量的光子产生的二次电子的相空间文件。计算了二次电子相空间文件在相关区域造成的总平均剂量及其在细胞内的微剂量分布,并与相同几何条件下初始光子造成的结果进行了比较。结果表明,采用二次电子相空间文件对宏观平均剂量的评估几乎没有影响,与培养皿中初始光子造成的总剂量相比,偏差低于3%。对于体细胞模型和两种不同形态的网状细胞模型的微观模拟分布,在宏观累积剂量为1 mGy时,初始光子和相空间文件产生的细胞剂量分布的相对偏差低于10%,相空间文件的总计算时间低于初始光子的2%。在累积剂量为 10、50 和 100 mGy 时,二次电子和初始光子获得的细胞核比能量的相对偏差大于 10%。随着培养皿尺寸的增大,细胞剂量分布的差异也在增大,剂量分布的均方根误差(RMSE)和变异系数(Cv)都超过了 30%。总之,本研究评估了利用相空间文件进行细胞尺度剂量评估的二次计算方法的有效性。这项研究为在细胞级微剂量测定研究中使用这种方法提供了重要的技术支持和理论基础。
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引用次数: 0
Utilizing acrylic acid polymer hydrogel for 3-D quality assurance in CyberKnife radiotherapy 利用丙烯酸聚合物水凝胶保证 CyberKnife 放射治疗的三维质量
IF 2.8 3区 物理与天体物理 Q3 CHEMISTRY, PHYSICAL Pub Date : 2024-10-15 DOI: 10.1016/j.radphyschem.2024.112300
Samer I. Awad , Khalid A. Rabaeh , Akram A. Almousa , Md A. Al Kafi , Ihssan S. Masad , Belal Moftah
Dosimetry tools play a crucial role in radiotherapy as they are essential for recording and validating intricate 3-D dose distributions. This research introduces and examines a novel acrylic acid polymer hydrogel (ACAPHG) dosimeter composition designed for 3-D dose verification and quality assurance in the context of radiotherapy treatment. A phantom made of an 80 mm diameter cylindrical glass container was utilized. The phantom contained the hydrogel, which served as the medium for radiation exposure. The water equivalent hydrogel within the phantom was subjected to irradiation by a CyberKnife robotic radiotherapy system. An optical computed tomography (OCT) scanner with sub-millimeter resolution was used to obtain imaging data. The dose distribution of a CyberKnife robotic SRS/SBRT treatment plan for a brain cancer patient was compared to that of the hydrogel's OCT scan using 2-D and 3-D gamma analysis with a criterion of 3% dose difference and 3 mm distance-to-agreement. A gamma pass rate of 94.1% for the 2-D gamma analysis and a pass rate of 99% for the 3-D gamma analysis were calculated within the region at which the treatment planning system data drops to 20% of the maximum dose. The use of the ACAPHG dosimeter in conjunction with the described setup suggests that it has the potential to offer an accurate 3-D verification of complex dose distributions in SRS/SBRT radiotherapy treatments. By employing the ACAPHG dosimeter and utilizing OCT scanning, this dosimeter enables the assessment and validation of intricate dose distributions in these advanced radiotherapy treatments.
剂量测定工具在放射治疗中发挥着至关重要的作用,因为它们对于记录和验证复杂的三维剂量分布至关重要。本研究介绍并研究了一种新型丙烯酸聚合物水凝胶(ACAPHG)剂量计组合物,该组合物设计用于放射治疗中的三维剂量验证和质量保证。该模型由一个直径为 80 毫米的圆柱形玻璃容器制成。模型中的水凝胶是辐射照射的介质。模型内的水等效水凝胶接受 CyberKnife 机器人放射治疗系统的照射。使用亚毫米分辨率的光学计算机断层扫描(OCT)扫描仪获取成像数据。通过二维和三维伽马分析,以 3% 的剂量差和 3 毫米的相差距离为标准,比较了 CyberKnife 机器人 SRS/SBRT 脑癌患者治疗方案的剂量分布与水凝胶 OCT 扫描的剂量分布。在治疗计划系统数据下降到最大剂量的 20% 的区域内,二维伽马分析的伽马通过率为 94.1%,三维伽马分析的通过率为 99%。ACAPHG 剂量计与所述装置的结合使用表明,它有潜力为 SRS/SBRT 放射治疗中的复杂剂量分布提供精确的三维验证。通过使用 ACAPHG 剂量计和 OCT 扫描,该剂量计能够评估和验证这些先进放射治疗中复杂的剂量分布。
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引用次数: 0
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Radiation Physics and Chemistry
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