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Exposure to Polycyclic Aromatic Hydrocarbons and adverse reproductive outcomes in women: current status and future perspectives. 接触多环芳烃与妇女的不良生殖后果:现状与未来展望。
IF 3 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2023-01-02 Print Date: 2024-06-25 DOI: 10.1515/reveh-2022-0182
Ata Rafiee, Mohammad Hoseini, Sadaf Akbari, E Melinda Mahabee-Gittens

Objectives: Polycyclic Aromatic Hydrocarbons (PAHs) are ubiquitous, toxic environmental chemicals that can cause adverse reproductive health effects. The objectives of this mini-review are to highlight the adverse reproductive outcomes due to PAH exposure with the main focus on polycystic ovary syndrome (PCOS) and premature ovarian failure (POF) and to provide perspectives on future research needs.

Content: We reviewed studies that have reported the adverse reproductive outcomes associated with PAHs exposures in women through a comprehensive search of bibliographic databases and gray literature sources. In addition, potentially modifiable sources of exposure to PAHs and associated reproductive outcomes were also investigated.

Summary: A total of 232 papers were retrieved through a comprehensive search of bibliographic databases, out of which three studies met the eligibility criteria and were included in the review. Results showed that exposure to PAHs is associated with adverse reproductive outcomes defined as PCOS, POF, and reproductive hormone imbalance. Sources of PAH exposure associated with adverse reproductive outcomes include active and passive tobacco smoking, specific cooking methods, and pesticides.

Outlook: Future studies are warranted to examine the mechanisms by which PAHs result in adverse reproductive endpoints in women. Further, environmental exposures that are potentially modifiable such as exposure to tobacco smoke, may contribute to PAH exposure, and these exposures should be targeted in future policies and interventions.

目标:多环芳烃(PAHs)是一种无处不在的有毒环境化学物质,可对生殖健康造成不良影响。本微型综述旨在强调多环芳烃暴露导致的不良生殖后果,重点关注多囊卵巢综合症(PCOS)和卵巢早衰(POF),并对未来的研究需求提出展望:内容:通过对文献数据库和灰色文献来源的全面检索,我们对报道了与女性多环芳烃暴露相关的不良生殖后果的研究进行了回顾。此外,我们还调查了多环芳烃潜在的可改变暴露源及相关生殖结果。摘要:通过对文献数据库的全面检索,我们共检索到 232 篇论文,其中有三项研究符合资格标准并被纳入综述。结果显示,多环芳烃暴露与多囊卵巢综合症、宫外孕和生殖激素失衡等不良生殖结果有关。与不良生殖结果相关的多环芳烃暴露源包括主动和被动吸烟、特定烹饪方法和杀虫剂:未来有必要开展研究,探讨多环芳烃导致女性不良生殖结局的机制。此外,烟草烟雾等潜在可改变的环境暴露可能会导致多环芳烃暴露,未来的政策和干预措施应针对这些暴露。
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引用次数: 0
A systematic review on environmental perspectives of monkeypox virus. 关于猴痘病毒环境前景的系统综述。
IF 3 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2023-01-02 Print Date: 2024-06-25 DOI: 10.1515/reveh-2022-0221
Sara Hemati, Fazel Mohammadi-Moghadam

Monkeypox (MPX) is one of the common infections between humans and animals that caused by a virus belonging to the Orthopoxvirus genus. The Monkeypox virus (MPXV) outbreak is a global crisis triggered by environmental factors (virus, wastewater, surface, air) and amplified by the decisions of government officials and communities. The aim of this systematic review is to describe the environmental perspectives of MPXV with emphasis on risk assessment to prevent and control a new pandemic. Five online databases including Web of Science, PubMed, Scopus, Science Direct and Google Scholar were searched from 1990 to October 2022. Among 120 records, after the screening, four studies were included in the systematic review. The systematic review revealed that the possibility of MPXV transmission through wastewater, air, and the contaminated surfaces is a significant concern and its detection and destroying will play a major role in controlling the spread of the virus. Poxviruses have a high environmental stability, but are sensitive to all common chemical disinfectants. In conclusion, this study revealed that the environmental surveillance can be used as a complementary tool for detecting pathogens circulation in communities. This implies that the monitoring of environmental perspectives of MPXV can provide new awareness into virus transmission routes as well as the role of stakeholders and public health policies in MPXV risk management.

猴痘(MPX)是人与动物之间常见的传染病之一,由一种属于正痘病毒属的病毒引起。猴痘病毒(MPXV)的爆发是一场全球性危机,由环境因素(病毒、废水、地表、空气)引发,并因政府官员和社区的决策而扩大。本系统综述旨在从环境角度描述 MPXV,重点是风险评估,以预防和控制新的大流行病。我们检索了 1990 年至 2022 年 10 月期间的五个在线数据库,包括 Web of Science、PubMed、Scopus、Science Direct 和 Google Scholar。经过筛选,在 120 条记录中,有 4 项研究被纳入系统综述。系统综述显示,MPXV 通过废水、空气和受污染表面传播的可能性是一个值得关注的重大问题,其检测和消灭将在控制病毒传播方面发挥重要作用。痘病毒具有高度的环境稳定性,但对所有常见的化学消毒剂都很敏感。总之,这项研究表明,环境监测可作为检测社区病原体循环的补充工具。这意味着,从环境角度监测 MPXV 可使人们对病毒传播途径以及利益相关者和公共卫生政策在 MPXV 风险管理中的作用有新的认识。
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引用次数: 0
Review of the scientific evidence on the individual sensitivity to electromagnetic fields (EHS). 个人电磁场敏感性的科学证据综述。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2022-09-27 DOI: 10.1515/reveh-2021-0038
Dariusz Leszczynski

Part of the population considers themselves as sensitive to the man-made electromagnetic radiation (EMF) emitted by powerlines, electric wiring, electric home appliance and the wireless communication devices and networks. Sensitivity is characterized by a broad variety of non-specific symptoms that the sensitive people claim to experience when exposed to EMF. While the experienced symptoms are currently considered as a real life impairment, the factor causing these symptoms remains unclear. So far, scientists were unable to find causality link between symptoms experienced by sensitive persons and the exposures to EMF. However, as presented in this review, the executed to-date scientific studies, examining sensitivity to EMF, are of poor quality to find the link between EMF exposures and sensitivity symptoms of some people. It is logical to consider that the sensitivity to EMF exists but the scientific methodology used to find it is of insufficient quality. It is time to drop out psychology driven provocation studies that ask about feelings-based non-specific symptoms experienced by volunteers under EMF exposure. Such research approach produces only subjective and therefore highly unreliable data that is insufficient to prove, or to disprove, causality link between EHS and EMF. There is a need for a new direction in studying sensitivity to EMF. The basis for it is the notion of a commonly known phenomenon of individual sensitivity, where individuals' responses to EMF depend on the genetic and epigenetic properties of the individual. It is proposed here that new studies, combining provocation approach, where volunteers are exposed to EMF, and high-throughput technologies of transcriptomics and proteomics are used to generate objective data, detecting molecular level biochemical responses of human body to EMF.

部分市民认为自己对电力线、电线、家用电器及无线通讯装置及网络发出的人造电磁辐射敏感。敏感的特点是敏感的人声称在接触电磁场时会出现各种各样的非特异性症状。虽然所经历的症状目前被认为是一种现实生活障碍,但引起这些症状的因素仍不清楚。到目前为止,科学家们还无法找到敏感人群所经历的症状与接触电磁场之间的因果关系。然而,正如本综述所述,迄今为止进行的关于电磁场敏感性的科学研究质量较差,无法发现电磁场暴露与某些人的敏感性症状之间的联系。合乎逻辑地认为,对电磁场的敏感性是存在的,但用于发现它的科学方法质量不足。现在是时候放弃心理学驱动的挑衅研究了,这些研究询问志愿者在电磁场暴露下经历的基于感觉的非特异性症状。这种研究方法只产生主观的,因此高度不可靠的数据,不足以证明或反驳EHS与EMF之间的因果关系。电动势敏感性的研究需要一个新的方向。它的基础是一种众所周知的个体敏感性现象的概念,其中个体对电磁场的反应取决于个体的遗传和表观遗传特性。本文提出了新的研究,结合激发方法,志愿者暴露于电磁场中,并使用高通量转录组学和蛋白质组学技术来生成客观数据,检测人体对电磁场的分子水平生化反应。
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引用次数: 13
The effect of long-term exposure to toxic air pollutants on the increased risk of malignant brain tumors. 长期暴露于有毒空气污染物对恶性脑肿瘤风险增加的影响。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2022-06-28 Print Date: 2023-09-26 DOI: 10.1515/reveh-2022-0033
Yousef Nikmanesh, Mohammad Javad Mohammadi, Homayon Yousefi, Sara Mansourimoghadam, Masoume Taherian

Toxic air pollutants are one of the most agent that have many acute, chronic and non-communicable diseases (NCDs) on human health under long or short-term exposure has been raised from the past to the present. The aim of this study was investigation effect of long-term exposure to toxic air pollutants on the increased risk of malignant brain tumors. Databases used to for searched were the PubMed, Web of Science, Springer and Science Direct (Scopus) and Google Scholar. 71 papers based on abstract and article text filtered. In the end after sieve we selected 7 papers. Identify all relevant studies published 1970-2022. The literature showed that exposure to toxic air pollutants and their respiration can cause disorders in different parts of the brain by transmission through the circulatory system and other mechanisms. Various unpleasant abnormalities are caused by the inhalation of toxic air pollutants in the human body that some of the most common of them include chronic lung disease, coronary heart disease and heart attacks, strokes and brain diseases (Parkinson's, Alzheimer's and multiple Sclerosis), cancers (liver, blood, prostate and brain) and eventually death. According to the finding brain health and proper functioning can be easily disrupted by various genetic or external factors such as air pollution, causing a wide range of abnormalities in the brain and malignant brain tumors. The results of this study showed that reducing the concentration of toxic pollutants in the air, that exposure to them play an increasing role in the development of brain diseases can slow down the process of abnormalities in the brain and will have significant impacts on reducing the number of people affected by them.

有毒空气污染物是许多急性、慢性和非传染性疾病(NCDs)在长期或短期暴露下对人类健康影响最大的病原体之一,从过去到现在都有人提出。本研究的目的是调查长期暴露于有毒空气污染物对恶性脑肿瘤风险增加的影响。过去搜索的数据库有PubMed、Web of Science、Springer and Science Direct(Scopus)和Google Scholar。71篇论文基于摘要和文章文本进行过滤。最后筛选出7篇论文。确定1970-2022年发表的所有相关研究。文献表明,暴露于有毒空气污染物及其呼吸会通过循环系统和其他机制传播,导致大脑不同部位的紊乱。人体吸入有毒空气污染物会导致各种令人不快的异常,其中最常见的包括慢性肺病、冠心病和心脏病发作、中风和脑部疾病(帕金森氏症、阿尔茨海默氏症和多发性硬化症)、癌症(肝、血、前列腺和大脑),最终导致死亡。根据研究结果,大脑健康和正常功能很容易被各种遗传或外部因素(如空气污染)破坏,导致大脑出现广泛异常和恶性脑肿瘤。这项研究的结果表明,降低空气中有毒污染物的浓度,使其在脑部疾病的发展中发挥越来越大的作用,可以减缓大脑异常的过程,并将对减少受其影响的人数产生重大影响。
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引用次数: 5
Using biomonitoring as a complementary approach in BTEX exposure assessment in the general population and occupational settings: a systematic review and meta-analysis. 在普通人群和职业环境中使用生物监测作为BTEX暴露评估的补充方法:系统回顾和荟萃分析。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2022-06-27 Print Date: 2023-09-26 DOI: 10.1515/reveh-2022-0042
Mohammad Hoseini, Mohammad Reza Samaei, Armita Shahesmaeili, Susana Silva Martínez, Hoda Amiri

Hazardous organic compounds such as benzene, toluene, ethylbenzene, o-xylene, m-xylene, and p-xylene (known as BTEX) found at work and at home can cause adverse health effects of human beings throughout their lives. Biological monitoring, an exposure assessment method, considers all exposed organic and non-organic compounds. Our goal was to perform a systematic review and a statistical analysis (meta-analysis) of peer-reviewed publications to assess urinary concentrations of BTEX biomarkers in both occupationally-exposed population and the general population. Several major electronic databases, including Scopus, Embase, Medline, Web of Science, and Google scholar (grey literature), were searched for biomonitoring studies of BTEX. Overall, 33 studies met the eligible criteria for the systematic review and six met the full inclusion criteria for meta-analysis. For meta-analysis, we included studies in which unmetabolized BTEX compounds were measured in urine samples. Due to insufficient data, studies that measured BTEX metabolites in urine samples and unmetabolized BTEX compounds in blood samples were excluded from the meta-analysis but were analyzed in the qualitative synthesis. Most studies showed increased urinary concentrations of BTEX in exposed individuals (mainly workers) compared to unexposed individuals. The results showed that the highest total BTEX concentrations were recorded in painters and policemen. This study showed that the undoubted associations between lifestyle and environmental factors and urinary levels of BTEX or its metabolites have not yet been confirmed in current biomonitoring studies. This is attributed to the few studies reported in this research area, the lack of homogeneous information, and the disagreement in the published results of the studies.

在工作和家庭中发现的苯、甲苯、乙苯、邻二甲苯、间二甲苯和对二甲苯(称为BTEX)等危险有机化合物会对人类一生的健康造成不利影响。生物监测是一种暴露评估方法,考虑所有暴露的有机和非有机化合物。我们的目标是对同行评审的出版物进行系统综述和统计分析(荟萃分析),以评估职业暴露人群和普通人群中BTEX生物标志物的尿液浓度。搜索了几个主要的电子数据库,包括Scopus、Embase、Medline、Web of Science和谷歌学者(灰色文献),以进行BTEX的生物监测研究。总体而言,33项研究符合系统综述的合格标准,6项符合荟萃分析的完全纳入标准。在荟萃分析中,我们纳入了在尿液样本中测量未代谢BTEX化合物的研究。由于数据不足,测量尿液样本中BTEX代谢物和血液样本中未代谢BTEX化合物的研究被排除在荟萃分析之外,但在定性合成中进行了分析。大多数研究表明,与未暴露的个体相比,暴露个体(主要是工人)的尿中BTEX浓度增加。结果表明,油漆工和警察的BTEX总浓度最高。这项研究表明,生活方式和环境因素与尿中BTEX或其代谢物水平之间的毋庸置疑的联系尚未在当前的生物监测研究中得到证实。这归因于该研究领域报告的研究较少,缺乏同质信息,以及已发表的研究结果存在分歧。
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引用次数: 1
Self-referencing authorships behind the ICNIRP 2020 radiation protection guidelines. ICNIRP 2020辐射防护指南背后的自参考作者。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2022-06-27 Print Date: 2023-09-26 DOI: 10.1515/reveh-2022-0037
Else K Nordhagen, Einar Flydal

In March 2020, ICNIRP (the International Commission for Non-Ionizing Radiation Protection) published a set of guidelines for limiting exposure to electromagnetic fields (100 kHz to 300 GHz). ICNIRP claims this publication's view on EMF and health, a view usually termed "the thermal-only paradigm", is consistent with current scientific understanding. We investigated the literature referenced in ICNIRP 2020 to assess if the variation in authors and research groups behind it meets the fundamental requirement of constituting a broad scientific base and thus a view consistent with current scientific understanding, a requirement that such an important set of guidelines is expected to satisfy. To assess if this requirement has been met, we investigated the span of authors and research groups of the referenced literature of the ICNIRP 2020 Guidelines and annexes. Our analysis shows that ICNIRP 2020 itself, and in practice all its referenced supporting literature stem from a network of co-authors with just 17 researchers at its core, most of them affiliated with ICNIRP and/or the IEEE, and some of them being ICNIRP 2020 authors themselves. Moreover, literature reviews presented by ICNIRP 2020 as being from independent committees, are in fact products of this same informal network of collaborating authors, all committees having ICNIRP 2020 authors as members. This shows that the ICNIRP 2020 Guidelines fail to meet fundamental scientific quality requirements and are therefore not suited as the basis on which to set RF EMF exposure limits for the protection of human health. With its thermal-only view, ICNIRP contrasts with the majority of research findings, and would therefore need a particularly solid scientific foundation. Our analysis demonstrates the contrary to be the case. Hence, the ICNIRP 2020 Guidelines cannot offer a basis for good governance.

2020年3月,ICNIRP(国际非电离辐射防护委员会)发布了一套限制暴露于电磁场(100 kHz至300 GHz)的指南。ICNIRP声称,该出版物对EMF和健康的看法,通常被称为“仅热范式”,与当前的科学理解一致。我们调查了ICNIRP 2020中引用的文献,以评估其背后的作者和研究群体的差异是否符合构成广泛科学基础的基本要求,从而符合当前科学理解的观点,这是一套如此重要的指导方针所期望满足的要求。为了评估是否满足了这一要求,我们调查了ICNIRP 2020指南和附件参考文献的作者和研究小组的范围。我们的分析表明,ICNIRP 2020本身,以及在实践中,其所有引用的支持文献都源于一个以17名研究人员为核心的合著者网络,其中大多数研究人员隶属于ICNIRP和/或IEEE,其中一些人本身就是ICNIRP的作者。此外,ICNIRP 2020提交的来自独立委员会的文献综述实际上是同一个非正式合作作者网络的产物,所有委员会都有ICNIRP的2020作者作为成员。这表明,ICNIRP 2020指南不符合基本的科学质量要求,因此不适合作为设定RF EMF暴露限值以保护人类健康的基础。ICNIRP仅从热学角度出发,与大多数研究结果形成对比,因此需要特别坚实的科学基础。我们的分析表明情况恰恰相反。因此,ICNIRP 2020指南不能为善治提供基础。
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引用次数: 6
A systematic review of photocatalytic degradation of humic acid in aqueous solution using nanoparticles. 纳米颗粒光催化降解水溶液中腐殖酸的系统综述。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2022-06-24 Print Date: 2023-09-26 DOI: 10.1515/reveh-2022-0046
Elham Derakhshani, Ali Naghizadeh, Morteza Arab-Zozani, Tahereh Farkhondeh

Objectives: Humic acid (HA) compounds in the disinfection processes of drinking water and wastewater are considered as precursors of highly toxic, carcinogenic and mutagenic disinfectant by-products. The aim of this study was to systematically review all research studies on the photocatalytic degradation of humic acid and to evaluate the laboratory conditions and results of these studies.

Content: The present systematic review was performed by searching the Scopus, PubMed, and web of science databases until December 2021. The parameters of type of catalyst, catalyst size, optimum pH, optimum initial concentration of humic Acid, optimum catalyst concentration, optimum time, light used and removal efficiency were investigated.

Summary: 395 studies were screened and using the inclusion and exclusion criteria, in total, 20 studies met our inclusion criteria and provided the information necessary to Photocatalytic degradation of humic acid by nanoparticles. In the investigated studies, the percentage of photocatalytic degradation of humic acid by nanoparticles was reported to be above 70%, and in some studies, the removal efficiency had reached 100%.

Outlook: From the results of this systematic review, it was concluded that the photocatalytic process using nanoparticles has a high effect on the degradation of humic acid.

目的:饮用水和废水消毒过程中的腐殖酸(HA)化合物被认为是剧毒、致癌和致突变性消毒副产物的前体。本研究的目的是系统地回顾所有关于光催化降解腐殖酸的研究,并评估这些研究的实验室条件和结果。内容:本系统综述是通过搜索Scopus、PubMed和web of science数据库进行的,直到2021年12月。考察了催化剂类型、催化剂大小、最佳pH、腐殖酸的最佳初始浓度、最佳催化剂浓度、最佳时间、光照和去除效率等参数。综述:共筛选了395项研究,使用纳入和排除标准,共有20项研究符合我们的纳入标准,并为纳米颗粒光催化降解腐殖酸提供了必要的信息。在所研究的研究中,据报道,纳米颗粒光催化降解腐殖酸的比例超过70%,在一些研究中,去除率达到100%。展望:从本系统综述的结果来看,使用纳米颗粒的光催化过程对腐殖酸的降解有很高的影响。
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引用次数: 3
Review, meta-analysis and carcinogenic risk assessment of aflatoxin M1 in different types of milks in Iran. 伊朗不同类型牛奶中黄曲霉毒素M1的回顾、荟萃分析和致癌风险评估。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2022-06-24 Print Date: 2023-09-26 DOI: 10.1515/reveh-2022-0050
Fatemeh Mortezazadeh, Fathollah Gholami-Borujeni

Reviews: Despite in recent decades, several studies on the concentration of aflatoxins M1(AFM1) in various milks have been studied, as we know, no systematic review, meta-analysis and carcinogenic risk assessment study was conducted in Iran till now.

Objectives: In this study, a systematic review was conducted to collect, meta-analysis and carcinogenic risk assessment of the quantitative data regarding the prevalence and concentration of AFM1 in several types of milk produced in Iran.

Content: In our study, the concentration and prevalence of AFM1 in different types of milk (Raw, pasteurized, and UHT) from 113 original articles in Iran using searching the Web of Science, PubMed, Scopus, Science Direct and Google Scholar (in Persian and English) databases from 2002 to august 2021 were collected. The concentration of AFM1 was meta-analyzed using the random effect model (REM) based on type of milk (raw, pasteurized and UHT) subgroups and Monte Carlo simulation (MCS) approach was used to assess safety risks and investigate carcinogenic effects of AFM1 using Crystal-Ball software (Version 11.1.3, Oracle, Inc., USA).

Summary and outlook: The 113 original article (In English and Persian) were included in this review. Meta-analysis indicated lower and upper of AFM1 in subgroups of raw, pasteurized and UHT milk in Iran was 9, 720, 2.7, 230.2, 19.23, and 221.6 ng/kg respectively. The Point estimate for carcinogenic risk of AFM1 showed as result of age increasing, the carcinogenic risk of Aflatoxin M 1 decreases and concentration of Aflatoxin M1 (ng/liter), plays the most effective role in carcinogenic risk of AFM1.

Conclusion: The presence of AFM1 in milk and its products due to its high toxicity and carcinogenic properties is a public health concern that the results show that the risk of carcinogenesis is higher at younger ages (less than 20 years). As a result, there is a strong association between consumption of raw milk, pasteurized milk and UHT and the risk of cancer in children and adults in Iran.

综述:尽管近几十年来,对各种牛奶中黄曲霉毒素M1(AFM1)的浓度进行了几项研究,但我们知道,迄今为止,伊朗还没有进行系统综述、荟萃分析和致癌风险评估研究。目的:本研究对伊朗生产的几种牛奶中AFM1的流行率和浓度的定量数据进行了系统的收集、荟萃分析和致癌风险评估。内容:在我们的研究中,2002年至2021年8月,使用搜索Web of Science、PubMed、Scopus、Science Direct和Google Scholar(波斯语和英语)数据库,收集了伊朗113篇原创文章中不同类型牛奶(生牛奶、巴氏灭菌牛奶和超高温灭菌牛奶)中AFM1的浓度和流行率。使用随机效应模型(REM)对AFM1的浓度进行元分析,该模型基于牛奶类型(生的、巴氏灭菌的和UHT)亚组,并使用蒙特卡罗模拟(MCS)方法评估安全风险,并使用Crystal-Ball软件(11.1.3版,Oracle,股份有限公司,USA)研究AFM1的致癌作用包含在本综述中。荟萃分析表明,伊朗生牛奶、巴氏灭菌牛奶和超高温灭菌牛奶亚组中AFM1的下限和上限分别为9200、2.7230.2、19.23和221.6纳克/公斤。AFM1致癌风险的点估计表明:随着年龄的增长,黄曲霉毒素M1的致癌风险降低,结论:牛奶及其制品中存在的AFM1由于其高毒性和致癌特性而引起公众健康关注,研究结果表明,年轻人(20岁以下)致癌风险更高。因此,在伊朗,生牛奶、巴氏灭菌牛奶和超高温灭菌与儿童和成人癌症风险之间存在着强烈的关联。
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引用次数: 1
Nano-engineered vitamins as a potential epigenetic modifier against environmental air pollutants. 纳米工程维生素作为一种潜在的表观遗传调节剂对抗环境空气污染物。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2022-06-21 Print Date: 2023-09-26 DOI: 10.1515/reveh-2022-0027
Pooja Ratre, Prachi Chauhan, Arpit Bhargava, Rajnarayan Tiwari, Suresh Thareja, Rupesh Kumar Srivastava, Pradyumna Kumar Mishra

Air pollution has emerged as a serious threat to human health due to close association with spectrum of chronic ailments including cardiovascular disorders, respiratory diseases, nervous system dysfunctions, diabetes and cancer. Exposure to air-borne pollutants along with poor eating behaviours and inferior dietary quality irreversibly impacts epigenomic landscape, leading to aberrant transcriptional control of gene expression which is central to patho-physiology of non-communicable diseases. It is assumed that nutriepigenomic interventions such as vitamins can control such adverse effects through their immediate action on mitochondrial epigenomic-axis. Importantly, the exhaustive clinical utility of vitamins-interceded epigenetic synchronization is not well characterized. Therefore, improving the current limitations linked to stability and bioavailability issues in vitamin formulations is highly warranted. The present review not only sums up the available data on the role of vitamins as potential epigenetic modifiers but also discusses the importance of nano-engineered vitamins as potential epidrugs for dietary and pharmacological intervention to mitigate the long-term effects of air pollution toxicity.

由于与心血管疾病、呼吸系统疾病、神经系统功能障碍、糖尿病和癌症等一系列慢性疾病密切相关,空气污染已成为对人类健康的严重威胁。暴露于空气传播的污染物以及不良的饮食行为和较差的饮食质量会不可逆转地影响表观基因组景观,导致基因表达的异常转录控制,这是非传染性疾病病理生理学的核心。据推测,维生素等营养表观基因组干预措施可以通过对线粒体表观基因组轴的直接作用来控制这种不良影响。重要的是,维生素介导的表观遗传同步的详尽临床效用并没有得到很好的表征。因此,改善目前维生素制剂中与稳定性和生物利用度问题相关的限制是非常有必要的。本综述不仅总结了维生素作为潜在表观遗传学修饰剂的作用的现有数据,还讨论了纳米工程维生素作为潜在的表观药物在饮食和药理学干预中的重要性,以减轻空气污染毒性的长期影响。
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引用次数: 1
The effect of toxic air pollutants on fertility men and women, fetus and birth rate. 有毒空气污染物对生育能力、胎儿和出生率的影响。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2022-06-20 Print Date: 2023-09-26 DOI: 10.1515/reveh-2022-0032
Ria Margiana, Homayon Yousefi, Arghavan Afra, Agustinus Agustinus, Walid Kamal Abdelbasset, Mariya Kuznetsova, Sara Mansourimoghadam, Hafez Ajam Ekrami, Mohammad Javad Mohammadi

Human health is affected by various factors such as air pollutants. Exposure to toxic air pollutants is impaired fertility in men and women. The purpose of this review study was investigation of the effect of toxic air pollutants on fertility and birth rate. Databases used to for searched were the PubMed, Web of Science, Springer and Science Direct (Scopus) and Google Scholar. Identify all relevant studies published 1999-2022. In this study, according to databases five hundred articles were retrieved. 33 studies were screened after review and 19 full-text articles entered into the analysis process. Finally, 11 articles were selected in this study. The literature signs a notable health effects from toxic air pollutants and increase risk of infertility in men and women and having a variety of reproductive system cancers such as prostate, bladder, ovary, kidney and uterus. According to the finding toxic air pollutants can increase the risk infertility in men and women, incidence of cancers of reproductive system and decrease the birth rate. Activities that play an important role in reducing the health effects of toxic air pollutants such as infertility in men and women and reducing the population rate of communities are improving the quality of fuel used in the home, car, industries, changing production processes in large industries, installing catalysts to reduce emissions in cars, use more public transportation, plant trees and increase green space per capita, increase public awareness about various effects of toxic air pollutants and protective measures.

人类健康受到空气污染物等多种因素的影响。暴露于有毒空气污染物会损害男性和女性的生育能力。本综述研究的目的是调查有毒空气污染物对生育率和出生率的影响。过去搜索的数据库有PubMed、Web of Science、Springer and Science Direct(Scopus)和Google Scholar。确定1999-2022年发表的所有相关研究。在这项研究中,根据数据库检索了500篇文章。33项研究在审查后进行了筛选,19篇全文文章进入了分析过程。最后,本研究选取了11篇文章。文献表明,有毒空气污染物对健康有显著影响,并增加男性和女性不孕的风险,以及患有前列腺、膀胱、卵巢、肾脏和子宫等多种生殖系统癌症的风险。根据研究发现,有毒的空气污染物会增加男性和女性不孕的风险,增加生殖系统癌症的发病率,并降低出生率。在减少男性和女性不孕不育等有毒空气污染物对健康的影响和降低社区人口率方面发挥重要作用的活动包括改善家庭、汽车和工业中使用的燃料质量,改变大工业的生产流程,安装催化剂以减少汽车排放,更多地使用公共交通,植树造林,增加人均绿地面积,提高公众对有毒空气污染物的各种影响和保护措施的认识。
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引用次数: 1
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Reviews on Environmental Health
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