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Association between food additives and prevalence of allergic reactions in children: a systematic review. 食品添加剂与儿童过敏反应发生率之间的关系:一项系统综述。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2023-03-28 DOI: 10.1515/reveh-2021-0158
Parisa Sadighara, Mehdi Safta, Intissar Limam, Kiandokht Ghanati, Zahra Nazari, Marzieh Karami, Amirhossein Abedini

Food additives contain synthetic and natural chemical compounds and are one of the causes of food allergies. In this regard, it is necessary to recognize the food additives that are of special interest for children. In this survey, the relation between food additives and allergic reactions and attention-deficit hyperactivity disorders in children was studied. The research studies with keywords "allergic reactions", "hypersensitivity", "food additives" and "children" were searched in PubMed, Scopus, Science Direct, Web of Science, and SID databases, from 1984 to 2020. Three hundred twenty-seven studies were obtained and only seven articles were finally selected according to exclusion and inclusion criteria. In the final review, seven articles were selected to investigate the relationship between food additives and hypersensitivity reactions. Some clinical factors such as urticaria, eczema, rhinitis and gastrointestinal symptoms and the prevalence of laboratory evidence in atopic children are due to increased exposure to food additives including artificial colors and sweeteners, preservatives, and monosodium glutamate. Clinical signs and laboratory evidence prove a significant association between some food additives and allergenic adverse reactions. It was also found that food additives such as artificial colors and sweeteners, preservatives, and monosodium glutamate are responsible for most cases of hypersensitivity in children, and the prevalence of hypersensitivity to food additives was estimated to be about 1.2% based on data extracted from studies.

食品添加剂含有合成和天然化合物,是引起食物过敏的原因之一。在这方面,有必要认识到儿童特别感兴趣的食品添加剂。本研究旨在探讨食品添加剂与儿童过敏反应及注意缺陷多动障碍的关系。在PubMed、Scopus、Science Direct、Web of Science、SID等数据库中检索1984 - 2020年以“allergic reactions”、“hypersensitivity”、“food additives”、“children”为关键词的研究。共获得327篇研究,最终根据排除和纳入标准筛选出7篇。在最后的回顾中,我们选择了7篇文章来研究食品添加剂与过敏反应的关系。一些临床因素,如荨麻疹、湿疹、鼻炎和胃肠道症状以及实验室证据在特应性儿童中的流行,是由于增加了对食品添加剂的接触,包括人工色素和甜味剂、防腐剂和味精。临床体征和实验室证据证明,某些食品添加剂与过敏性不良反应之间存在显著关联。研究还发现,人工色素和甜味剂、防腐剂和味精等食品添加剂是导致儿童过敏的主要原因,根据研究数据估计,对食品添加剂过敏的发生率约为1.2%。
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引用次数: 5
A review of microplastic pollution in commercial fish for human consumption. 供人类食用的商业鱼类中微塑料污染的研究进展。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2023-03-28 DOI: 10.1515/reveh-2021-0103
Pouran Makhdoumi, Hooshyar Hossini, Meghdad Pirsaheb

Today microplastics (MPs) have received worldwide attention as an emerging environmental pollution which is one of the four major global environmental threat and health hazard to human as well. Unfortunately, MPs have been founded in the all environments and media include air, water resources, sediments, and soil. It should not be forgotten MPs have also been detected in food and processing products like tuna. MPs can be ingested by marine organisms such as zooplankton, fish and birds. Accumulation and distribution of MPs by commercially important aquatic organisms is expected to lead to greater exposure risk for human populations with possible adverse effects over time. The aim of this work was to review the published literature regarding the contamination of commercial fish muscle for human consumption. Furthermore, a short revision of the environmental contamination and human health effects by MPs are included. We also estimated human daily intake considering the worldwide contamination of commercial fish muscle ranged from 0.016 items/g muscle of fish to 6.06 items/g muscle of fish. MPs have been found in 56.5% of the commercial fish samples analysed here. As fish is used in human food table across the word, they constitute a long-term exposure route for all humans and raise the concern about the potential public health risk.

微塑料作为全球四大环境威胁之一和危害人类健康的一种新兴环境污染,受到了世界各国的广泛关注。不幸的是,MPs存在于所有环境和媒介中,包括空气、水资源、沉积物和土壤。不应该忘记的是,在金枪鱼等食品和加工产品中也检测到MPs。MPs可被浮游动物、鱼类和鸟类等海洋生物吸收。具有重要商业价值的水生生物对多磺酸盐的积累和分布预计将导致人类更大的暴露风险,随着时间的推移可能产生不利影响。这项工作的目的是审查已发表的关于人类消费的商业鱼肌肉污染的文献。此外,还包括对MPs对环境污染和人类健康影响的简短修订。考虑到世界范围内商业鱼类肌肉的污染,我们还估计了人类每日摄入量,范围从0.016项/克鱼肉到6.06项/克鱼肉。在这里分析的56.5%的商业鱼类样本中发现了MPs。由于鱼类在世界各地被用于人类的餐桌上,它们构成了所有人类的长期接触途径,并引起了对潜在公共卫生风险的关注。
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引用次数: 12
Neurobiological effects of urban built and natural environment on mental health: systematic review. 城市建筑和自然环境对心理健康的神经生物学效应:系统综述。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2023-03-28 DOI: 10.1515/reveh-2021-0137
Ahmad Bolouki

Although rapid global urbanization improves people in many ways, it also increases the prevalence of major mental disorders in urban communities. Exposure to natural surroundings, whether real or virtual, on the other hand, has been found to reduce arousal and stress. The purpose of this study is to provide an overview of the existing literature on how brain function changes when exposed to natural and urban settings. As a highly effective technique for determining human brain activity, this review considers literature using neuroimaging techniques, i.e., electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS). SCOPUS and PubMed were searched for peer-reviewed literature published prior to September 2021. Twenty-six sources were included, returning 263 papers; 18 empirical articles published from 1991 to 2021 were included in the final synthesis. EEG findings were generally consistent with those obtained from fMRI/NIRS data. Natural settings were linked to greater alpha EEG values and fewer demands on information processing and stronger functional connectivity in fMRI/NIRS studies, which indicate feelings of relaxation and restoration. These findings offer a better understanding of the functional activities during environmental exposures and also imply that nature exposure improves cognitive functions and mental health.

尽管快速的全球城市化在许多方面改善了人们,但它也增加了城市社区中主要精神障碍的患病率。另一方面,暴露在自然环境中,无论是真实的还是虚拟的,都被发现可以减少兴奋和压力。本研究的目的是提供一个关于大脑功能在暴露于自然和城市环境时如何变化的现有文献的概述。作为一种非常有效的确定人脑活动的技术,本文回顾了使用神经成像技术的文献,即脑电图(EEG),功能磁共振成像(fMRI)和功能近红外光谱(fNIRS)。检索了SCOPUS和PubMed在2021年9月之前发表的同行评议文献。纳入26个来源,归还263篇论文;1991年至2021年发表的18篇实证文章被纳入最终综合。脑电图结果与fMRI/NIRS数据基本一致。在fMRI/NIRS研究中,自然环境与更高的阿尔法脑电图值、更少的信息处理需求和更强的功能连接有关,这表明放松和恢复的感觉。这些发现提供了对环境暴露期间的功能活动的更好理解,也意味着自然暴露可以改善认知功能和心理健康。
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引用次数: 6
Exposure to toxic occupations and their association with Parkinson's disease: a systematic review with meta-analysis. 接触有毒职业及其与帕金森病的关系:一项荟萃分析的系统综述。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2023-03-28 DOI: 10.1515/reveh-2021-0111
Tamara Chambers-Richards, Yingying Su, Batholomew Chireh, Carl D'Arcy

Objectives: Earlier longitudinal reviews on environmental and occupational toxins and Parkinson's disease (PD) risk have limitations. This study aimed to determine the strength of association between three types of toxic occupational exposures and the occurrence of PD by diagnostic methods.

Methods: A search was conducted of EMBASE, PubMed/Medline, Toxnet, LILACS, and Cochrane Library databases for longitudinal studies that assessed toxic occupational exposure, Parkinsonian, or related disorders, diagnosed by International Classification of Diseases (ICD) codes, medical records, or confirmation by a neurologist/nurse, and published in the English language from January 1990 to July 2021. Pooled risk ratios (RR) estimates were produced using random-effects models. Systematic review with meta-analysis synthesized the results. Study quality, heterogeneity, and publication bias were examined. High-quality articles that met the inclusion criteria were analyzed.

Results: Twenty-four articles were used in the analyses. The pooled RR for electromagnetic exposure and PD were (RR=1.03, 95% confidence interval [CI] 0.91-1.16) while the pooled RR between PD and metal and pesticide exposure were (RR=1.07, 95% CI 0.92-1.24) and (RR=1.41, 95% CI 1.20-1.65), respectively. Pooled RR for methods of diagnosis and their associations with PD were: confirmation by a neurologist or nurse (RR=2.17, 95% CI 1.32-3.54); ICD codes (RR=1.14, 95% CI 1.03-1.26), and medical records (RR=1.06, 95% CI 0.92-1.21).

Conclusions: Our systematic review provides robust evidence that toxic occupational exposures are significant risk factors for PD especially those diagnosed by neurologists or nurses using standardized methods.

目的:早期关于环境和职业毒素与帕金森病(PD)风险的纵向综述有局限性。本研究旨在通过诊断方法确定三种有毒职业暴露与PD发生的关联强度。方法:对EMBASE、PubMed/Medline、Toxnet、LILACS和Cochrane图书馆数据库进行了纵向研究,这些研究评估了毒性职业暴露、帕金森病或相关疾病,这些研究由国际疾病分类(ICD)代码诊断、医疗记录或由神经科医生/护士确认,并于1990年1月至2021年7月以英语发表。综合风险比(RR)估计采用随机效应模型。系统回顾和荟萃分析综合了这些结果。对研究质量、异质性和发表偏倚进行了检查。对符合纳入标准的高质量文章进行分析。结果:共纳入24篇文献。电磁暴露与PD的合并RR为(RR=1.03, 95%可信区间[CI] 0.91 ~ 1.16), PD与金属和农药暴露的合并RR为(RR=1.07, 95% CI 0.92 ~ 1.24)和(RR=1.41, 95% CI 1.20 ~ 1.65)。诊断方法及其与PD相关性的合并RR为:由神经科医生或护士确认(RR=2.17, 95% CI 1.32-3.54);ICD代码(RR=1.14, 95% CI 1.03-1.26)和医疗记录(RR=1.06, 95% CI 0.92-1.21)。结论:我们的系统综述提供了强有力的证据,表明有毒职业暴露是PD的重要危险因素,特别是那些由神经科医生或护士使用标准化方法诊断的PD。
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引用次数: 6
Children's exposure to polycyclic aromatic hydrocarbon (PAHs): a review on urinary 1-hydroxypyrene and associated health effects. 儿童接触多环芳烃(PAHs):尿中1-羟基芘及其相关健康影响的研究进展
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2023-03-28 DOI: 10.1515/reveh-2021-0013
Nur Hazirah Hisamuddin, Juliana Jalaludin

This article reviewed the published studies on the environmental exposure to polycyclic aromatic hydrocarbons (PAHs) among children and assessed the urinary 1-hydroxypyrene (1-OHP) level as a biomarker of exposure to PAHs. The current knowledge of the potential health effects of increased 1-OHP in children was reviewed. Additionally, the influence of genetic polymorphism on the urinary 1-OHP level was discussed in this review. The assembled data showed that children who are attending schools or living close to industrial and polluted urban areas might have greater exposure to higher concentrations of PAHs with a higher level of urinary 1-OHP when compared to those children living in rural areas. Urinary 1-OHP may be a reliable biomarker for determining the genotoxic effects, oxidative stress and inflammation caused by exposure to PAHs. Strong research evidence indicated that the total body burden of PAHs should be evaluated by biomonitoring of 1-OHP in line with other urinary PAHs metabolites (with 2-3 rings) to evaluate recent total exposure to PAHs. Overall, the study suggests implementing a mitigation plan to combat air pollution to provide a cleaner environment for children.

本文综述了儿童多环芳烃(PAHs)环境暴露的相关研究,并评价了尿中1-羟基芘(1-OHP)水平作为多环芳烃暴露的生物标志物。综述了目前对儿童1-OHP升高的潜在健康影响的认识。此外,本文还讨论了遗传多态性对尿1-OHP水平的影响。综合数据显示,与生活在农村地区的儿童相比,上学或生活在工业和污染城市地区附近的儿童可能接触到浓度较高的多环芳烃,尿液1-OHP水平也较高。尿1-OHP可能是确定暴露于多环芳烃引起的遗传毒性效应、氧化应激和炎症的可靠生物标志物。强有力的研究证据表明,应该通过生物监测1-OHP和其他尿液多环芳烃代谢物(2-3环)来评估多环芳烃的总体负荷,以评估最近的多环芳烃总暴露。总的来说,该研究建议实施一项缓解空气污染的计划,为儿童提供一个更清洁的环境。
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引用次数: 5
The radionuclides contamination in eggs as an environmental marker: a systematic review. 鸡蛋中放射性核素污染作为环境标志的系统综述。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2023-03-28 DOI: 10.1515/reveh-2021-0167
Parisa Sadighara, Afsaneh Mohajer, Ehsan Shamloo, Nader Akbari, Naiema Vakili Saatloo

Foods are contaminated with natural and man-made radionuclides. The aim of this systematic review was to determine the amount and type of radionuclides in eggs, as well as the biomarker capability of eggs. The research studies with keywords radionuclide, radioisotopes, contamination and egg were searched in PubMed, Scopus, and Science Direct databases, regardless of publication time. A number of 70 studies were obtained and only 13 articles were finally selected according to exclusion, inclusion criteria and quality assessment results. Studies which detected radionuclide in the hen eggs were selected. The highest frequency of radionuclides belonged to Ra-226 and Cs-137. The index of natural radionuclides is Ra-226 and the index of synthetic radionuclides is Cs-137. The local eggs, in addition to determining food contamination, can also be a good biomarker for identifying environmental contamination.

食物受到天然和人造放射性核素的污染。本系统综述的目的是确定鸡蛋中放射性核素的数量和类型,以及鸡蛋的生物标志物能力。在PubMed、Scopus和Science Direct数据库中检索以放射性核素、放射性同位素、污染和鸡蛋为关键词的研究,不考虑发表时间。根据排除标准、纳入标准和质量评价结果,共获得70篇研究,最终筛选出13篇。选择在鸡蛋中检测到放射性核素的研究。放射性核素的频率最高的是Ra-226和Cs-137。天然放射性核素的指数为Ra-226,合成放射性核素的指数为Cs-137。当地的鸡蛋,除了确定食物污染外,也可以作为识别环境污染的良好生物标志物。
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引用次数: 0
Frontmatter 头版头条
4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2023-03-01 DOI: 10.1515/reveh-2023-frontmatter1
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引用次数: 0
Monkeypox and drug repurposing: seven potential antivirals to combat the viral disease. 猴痘与药物再利用:七种潜在的抗病毒药物对抗病毒性疾病。
IF 3.9 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2023-02-22 DOI: 10.1515/reveh-2023-0001
Ryan Varghese, Pal Patel, Dileep Kumar, Rohit Sharma

The growing concern about the monkeypox (Mpox) virus infection has garnered a lot of public attention. However, the treatment options available to combat the same is limited to tecovirimat. Additionally, in a possible incidence of resistance, hypersensitivity, or adverse drug reaction, it is imperative to devise and reinforce the second-line therapy. Thus, in this editorial, the authors suggest seven antiviral drugs that could potentially be repurposed to combat the viral illness.

猴痘(Mpox)病毒感染日益受到关注,引起了公众的广泛关注。然而,现有的治疗方法仅限于替考韦瑞(tecovirimat)。此外,在可能出现耐药性、过敏性或药物不良反应的情况下,必须设计并加强二线疗法。因此,在这篇社论中,作者提出了七种抗病毒药物,这些药物有可能被重新用于抗击病毒性疾病。
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引用次数: 0
How does formal and informal industry contribute to lead exposure? A narrative review from Vietnam, Uruguay, and Malaysia. 正规和非正规工业如何导致铅暴露?来自越南、乌拉圭和马来西亚的叙述性综述。
IF 3 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2023-02-06 Print Date: 2024-06-25 DOI: 10.1515/reveh-2022-0224
Kritika Poudel, Atsuko Ikeda, Hisanori Fukunaga, Marie-Noel Brune Drisse, Lesley Jayne Onyon, Julia Gorman, Amalia Laborde, Reiko Kishi

Introduction: Lead industries are one of the major sources of environmental pollution and can affect human through different activities, including industrial processes, metal plating, mining, battery recycling, etc. Although different studies have documented the various sources of lead exposure, studies highlighting different types of industries as sources of environmental contamination are limited. Therefore, this narrative review aims to focus mainly on lead industries as significant sources of environmental and human contamination.

Content: Based on the keywords searched in bibliographic databases we found 44 relevant articles that provided information on lead present in soil, water, and blood or all components among participants living near high-risk areas. We presented three case scenarios to highlight how lead industries have affected the health of citizens in Vietnam, Uruguay, and Malaysia.

Summary and outlook: Factories conducting mining, e-waste processing, used lead-acid battery recycling, electronic repair, and toxic waste sites were the primary industries for lead exposure. Our study has shown lead exposure due to industrial activities in Vietnam, Uruguay, Malaysia and calls for attention to the gaps in strategic and epidemiologic efforts to understand sources of environmental exposure to lead fully. Developing strategies and guidelines to regulate industrial activities, finding alternatives to reduce lead toxicity and exposure, and empowering the public through various community awareness programs can play a crucial role in controlling exposure to lead.

导言:铅工业是环境污染的主要来源之一,可通过工业加工、金属电镀、采矿、电池回收等不同活动对人类造成影响。虽然不同的研究记录了铅暴露的各种来源,但强调不同类型工业是环境污染源的研究却很有限。因此,这篇叙述性综述旨在主要关注作为环境和人类污染重要来源的铅工业:根据在文献数据库中搜索的关键词,我们找到了 44 篇相关文章,这些文章提供了居住在高风险地区附近的参与者在土壤、水和血液中或所有成分中铅含量的信息。我们介绍了三个案例,以强调铅工业如何影响越南、乌拉圭和马来西亚公民的健康:进行采矿的工厂、电子废物处理、废旧铅酸电池回收、电子维修和有毒废物处理场是铅暴露的主要行业。我们的研究表明,越南、乌拉圭和马来西亚的铅暴露源于工业活动,并呼吁人们关注战略和流行病学工作中的差距,以充分了解环境中的铅暴露源。制定监管工业活动的战略和指导方针,寻找降低铅毒性和铅暴露的替代品,以及通过各种社区宣传计划增强公众的能力,在控制铅暴露方面可以发挥至关重要的作用。
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引用次数: 0
Mechanisms of cholera transmission via environment in India and Bangladesh: state of the science review. 印度和孟加拉国霍乱通过环境传播的机制:科学现状综述。
IF 3 4区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2023-01-16 Print Date: 2024-06-25 DOI: 10.1515/reveh-2022-0201
Debbie Shackleton, Fayyaz A Memon, Gordon Nichols, Revati Phalkey, Albert S Chen

Objectives: Cholera has a long history in India and Bangladesh, the region where six out of the past seven global pandemics have been seeded. The changing climate and growing population have led to global cholera cases remaining high despite a consistent improvement in the access to clean water and sanitation. We aim to provide a holistic overview of variables influencing environmental cholera transmission within the context of India and Bangladesh, with a focus on the mechanisms by which they act.

Content: We identified 56 relevant texts (Bangladesh n = 40, India n = 7, Other n = 5). The results of the review found that cholera transmission is associated with several socio-economic and environmental factors, each associated variable is suggested to have at least one mediating mechanism. Increases in ambient temperature and coastal sea surface temperature support cholera transmission via increases in plankton and a preference of Vibrio cholerae for warmer waters. Increased rainfall can potentially support or reduce transmission via several mechanisms.

Summary and outlook: Common issues in the literature are co-variance of seasonal factors, limited access to high quality cholera data, high research bias towards research in Dhaka and Matlab (Bangladesh). A specific and detailed understanding of the relationship between SST and cholera incidence remains unclear.

目的:霍乱在印度和孟加拉国有着悠久的历史,在过去的七次全球大流行中,有六次都发生在这一地区。不断变化的气候和不断增长的人口导致全球霍乱病例居高不下,尽管清洁水和卫生条件持续改善。我们旨在全面概述影响印度和孟加拉国环境霍乱传播的各种变量,重点关注这些变量的作用机制:我们确定了 56 篇相关文章(孟加拉国 40 篇,印度 7 篇,其他 5 篇)。综述结果发现,霍乱的传播与多个社会经济和环境因素有关,每个相关变量至少有一个中介机制。环境温度和沿海海面温度的升高会增加浮游生物的数量,霍乱弧菌也更喜欢温暖的水域,从而支持霍乱的传播。降雨量增加有可能通过多种机制支持或减少传播:文献中存在的共同问题是季节性因素的共变性、获取高质量霍乱数据的途径有限、对达卡和马特拉布(孟加拉国)研究的高度偏倚。对 SST 与霍乱发病率之间关系的具体和详细了解仍不清楚。
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引用次数: 0
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