Pub Date : 2026-01-08DOI: 10.1016/j.str.2025.12.004
Esko Oksanen
The high neutron flux of the European Spallation Source in Lund, Sweden, opens new possibilities for neutron protein crystallography. Making full use of these gains requires dedicated instrumentation and support facilities to maximize its contribution to our understanding of biological processes at the molecular level.
{"title":"Prospects for neutron protein crystallography at the European Spallation Source.","authors":"Esko Oksanen","doi":"10.1016/j.str.2025.12.004","DOIUrl":"https://doi.org/10.1016/j.str.2025.12.004","url":null,"abstract":"The high neutron flux of the European Spallation Source in Lund, Sweden, opens new possibilities for neutron protein crystallography. Making full use of these gains requires dedicated instrumentation and support facilities to maximize its contribution to our understanding of biological processes at the molecular level.","PeriodicalId":22168,"journal":{"name":"Structure","volume":"20 1","pages":"6-9"},"PeriodicalIF":5.7,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.str.2025.11.015
Paul G. Kremer, William D. Tolbert, Eliza Gazaway, Braulio G. Hernandez, Marek K. Korzeniowski, Zofia A. Dyba, Tobias Grelsson, Oliver C. Grant, William N. Lanzilotta, Marzena Pazgier, Robert J. Woods, Adam W. Barb
{"title":"The impact of N-glycan conformational entropy on the binding affinity of Fc γ receptor IIIa/CD16a","authors":"Paul G. Kremer, William D. Tolbert, Eliza Gazaway, Braulio G. Hernandez, Marek K. Korzeniowski, Zofia A. Dyba, Tobias Grelsson, Oliver C. Grant, William N. Lanzilotta, Marzena Pazgier, Robert J. Woods, Adam W. Barb","doi":"10.1016/j.str.2025.11.015","DOIUrl":"https://doi.org/10.1016/j.str.2025.11.015","url":null,"abstract":"","PeriodicalId":22168,"journal":{"name":"Structure","volume":"17 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.str.2025.11.017
Zaritza O. Petrova, Long Han, Yuko Tsutsui, Joshua B. Sheetz, Kumar D. Ashtekar, Mark A. Lemmon
{"title":"The role of kinase domain dimerization in EGFR activation","authors":"Zaritza O. Petrova, Long Han, Yuko Tsutsui, Joshua B. Sheetz, Kumar D. Ashtekar, Mark A. Lemmon","doi":"10.1016/j.str.2025.11.017","DOIUrl":"https://doi.org/10.1016/j.str.2025.11.017","url":null,"abstract":"","PeriodicalId":22168,"journal":{"name":"Structure","volume":"20 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.str.2025.11.013
Yutong He, Wenjie Fan, Jian Shi, Bee Koon Gan, Kai Shao, Fan Zhu, Xuechuan Hong, Min Luo
{"title":"Cryo-EM structure of the Nisin resistance pump PsdAB reveals an unusual ABC transporter architecture","authors":"Yutong He, Wenjie Fan, Jian Shi, Bee Koon Gan, Kai Shao, Fan Zhu, Xuechuan Hong, Min Luo","doi":"10.1016/j.str.2025.11.013","DOIUrl":"https://doi.org/10.1016/j.str.2025.11.013","url":null,"abstract":"","PeriodicalId":22168,"journal":{"name":"Structure","volume":"18 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.str.2025.11.014
Pooneh Tavakoley Gheinani, Aloke Bera, Julie Stoudenmire-Saylor, Yi Lien, Simone A. Harrison, Alison Criss, Walter J. Chazin, Nicholas Noinaj, Cynthia Nau Cornelissen
{"title":"Structural insights into zinc piracy by Neisseria gonorrhoeae to overcome nutritional immunity","authors":"Pooneh Tavakoley Gheinani, Aloke Bera, Julie Stoudenmire-Saylor, Yi Lien, Simone A. Harrison, Alison Criss, Walter J. Chazin, Nicholas Noinaj, Cynthia Nau Cornelissen","doi":"10.1016/j.str.2025.11.014","DOIUrl":"https://doi.org/10.1016/j.str.2025.11.014","url":null,"abstract":"","PeriodicalId":22168,"journal":{"name":"Structure","volume":"152 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.str.2025.11.016
Defne G. Ozgulbas, Timothy J.C. Tan, Po-Chao Wen, Qi Wen Teo, Huibin Lv, Zhaleh Ghaemi, Martin Frank, Nicholas C. Wu, Emad Tajkhorshid
{"title":"Probing the role of membrane in neutralizing activity of antibodies against influenza virus","authors":"Defne G. Ozgulbas, Timothy J.C. Tan, Po-Chao Wen, Qi Wen Teo, Huibin Lv, Zhaleh Ghaemi, Martin Frank, Nicholas C. Wu, Emad Tajkhorshid","doi":"10.1016/j.str.2025.11.016","DOIUrl":"https://doi.org/10.1016/j.str.2025.11.016","url":null,"abstract":"","PeriodicalId":22168,"journal":{"name":"Structure","volume":"29 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1016/j.str.2025.11.011
Maxwell J. Bachochin, Kelly L. McGuire, Brian D. Cook, Qiaozhen Ye, Steven Silletti, Kevin D. Corbett, Elizabeth A. Komives, Mark A. Herzik
{"title":"An allosteric network governs Tom70 conformational dynamics to coordinate mitochondrial import","authors":"Maxwell J. Bachochin, Kelly L. McGuire, Brian D. Cook, Qiaozhen Ye, Steven Silletti, Kevin D. Corbett, Elizabeth A. Komives, Mark A. Herzik","doi":"10.1016/j.str.2025.11.011","DOIUrl":"https://doi.org/10.1016/j.str.2025.11.011","url":null,"abstract":"","PeriodicalId":22168,"journal":{"name":"Structure","volume":"11 2 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/j.str.2025.11.012
Pu Hou, Jie Zhu, Rong-Cheng Yu, Feng Yang, Kang Du, Jing Li, Wen-Wen Kong, Jie Wang, Yuxing Chen, Cong-Zhao Zhou, Yong-Liang Jiang
Cyanophages, which are bacteriophages that specifically infect host cyanobacteria, also utilize the tail to initiate host recognition and adsorption. Owing to the limited structural information on cyanophages, our understanding of the mechanism by which cyanophages specifically recognize their hosts remains largely unknown. Here, we determined the intact cryoelectron microscopy structure of a freshwater cyanopodophage Pan3, which consists of an icosahedral shell and a short tail comprising four modular components: the dodecameric adaptor, hexameric nozzle, trimeric needle, and six heterohexameric tailspikes. Notably, each tailspike features an SGNH esterase domain fused to a lectin domain, forming a continuous groove complementary to the host lipopolysaccharide. These findings provide insights into the receptor engagement in Podoviridae, and establish a structural framework for cyanophage and host interactions that may guide future antibacterial interventions against harmful blooms.
{"title":"Cryo-EM structure of cyanopodophage Pan3 reveals a modular tail architecture for host recognition","authors":"Pu Hou, Jie Zhu, Rong-Cheng Yu, Feng Yang, Kang Du, Jing Li, Wen-Wen Kong, Jie Wang, Yuxing Chen, Cong-Zhao Zhou, Yong-Liang Jiang","doi":"10.1016/j.str.2025.11.012","DOIUrl":"https://doi.org/10.1016/j.str.2025.11.012","url":null,"abstract":"Cyanophages, which are bacteriophages that specifically infect host cyanobacteria, also utilize the tail to initiate host recognition and adsorption. Owing to the limited structural information on cyanophages, our understanding of the mechanism by which cyanophages specifically recognize their hosts remains largely unknown. Here, we determined the intact cryoelectron microscopy structure of a freshwater cyanopodophage Pan3, which consists of an icosahedral shell and a short tail comprising four modular components: the dodecameric adaptor, hexameric nozzle, trimeric needle, and six heterohexameric tailspikes. Notably, each tailspike features an SGNH esterase domain fused to a lectin domain, forming a continuous groove complementary to the host lipopolysaccharide. These findings provide insights into the receptor engagement in <em>Podoviridae</em>, and establish a structural framework for cyanophage and host interactions that may guide future antibacterial interventions against harmful blooms.","PeriodicalId":22168,"journal":{"name":"Structure","volume":"8 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1016/j.str.2025.11.009
The microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. Mutations associated with front…
微管相关蛋白tau与以淀粉样蛋白形成为特征的神经退行性疾病有关。与前…相关的突变
{"title":"Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context","authors":"","doi":"10.1016/j.str.2025.11.009","DOIUrl":"https://doi.org/10.1016/j.str.2025.11.009","url":null,"abstract":"The microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. Mutations associated with front…","PeriodicalId":22168,"journal":{"name":"Structure","volume":"372 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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