This editorial provides an overview of the economic, social, and political impacts of blockchain and introduces the papers published in the special issue. It discusses how blockchain can facilitate entrepreneurial ventures, optimize business operations, and enhance supply chain efficiency. The potential of central bank digital currencies to improve transaction efficiency and financial inclusion is also highlighted. Socially, blockchain is positioned to address labor abuses, improve working conditions, and combat corruption through enhanced transparency and accountability. However, risks such as illicit financing and high energy consumption are acknowledged. Overall, blockchain holds promise to transform economies, societies, and organizations, but thoughtful policymaking is needed to maximize benefits and mitigate unintended consequences. This editorial introduces papers in this special issue, which aim to expand understanding of blockchain's diverse applications and implications across institutional governance, business, sustainability, energy, and payments systems.