Objectives: Very few studies have been conducted to identify the conditions that cause poisoning in pediatric patients needing intensive care, both by age group and toxic agent factor. This study will support the development of strategies for poisoning prevention measures by comparing the data in our region with other data in the world. Methods: This study is a single-centered, retrospective study. The baseline status of acute poisoning was defined in pediatric patients aged one month to 18 years who required intensive care hospitalization between November 2017 and March 2022. Results: There were 148 patient admissions due to acute poisonings (5.2% of all admissions, 69.6% females, median age: 13.6 months). Our study revealed that acute poisoning in children is caused mainly by pharmacological (88.5%), oral intake (97.3%) and at home (85.8%). It was observed that intoxication peaked at two different ages; the first peak was at preschool (33.1%), and the second peak was at adolescence (58.7%). In the univariate analysis, females (odds ratio [OR]=4.1), adolescents (OR=167.6), psychiatric drug users (OR=55.5), and multiple drug intoxications (OR=3.6) were associated with more suicides. Being adolescents and using psychiatric medication contributed significantly to suicide attempts in multivariate analysis (OR=145.3 and OR=37.9). None of our patients died. Conclusions: Preventing both poisoning and suicide attempts is the most critical priority. However, we suggest prevention strategies should be strengthened even if mortality is not observed. Furthermore, our study shows that suicide attempts are very likely to be repeated, especially if an underlying psychiatric illness exists.
{"title":"Acute poisonings requiring intensive care in childhood and a hidden threat, suicide attempts: a single-center experience","authors":"A. Oto, S. Kılıç, M. Sahin","doi":"10.18621/eurj.1341860","DOIUrl":"https://doi.org/10.18621/eurj.1341860","url":null,"abstract":"Objectives: Very few studies have been conducted to identify the conditions that cause poisoning in pediatric patients needing intensive care, both by age group and toxic agent factor. This study will support the development of strategies for poisoning prevention measures by comparing the data in our region with other data in the world.\u0000Methods: This study is a single-centered, retrospective study. The baseline status of acute poisoning was defined in pediatric patients aged one month to 18 years who required intensive care hospitalization between November 2017 and March 2022. \u0000Results: There were 148 patient admissions due to acute poisonings (5.2% of all admissions, 69.6% females, median age: 13.6 months). Our study revealed that acute poisoning in children is caused mainly by pharmacological (88.5%), oral intake (97.3%) and at home (85.8%). It was observed that intoxication peaked at two different ages; the first peak was at preschool (33.1%), and the second peak was at adolescence (58.7%). In the univariate analysis, females (odds ratio [OR]=4.1), adolescents (OR=167.6), psychiatric drug users (OR=55.5), and multiple drug intoxications (OR=3.6) were associated with more suicides. Being adolescents and using psychiatric medication contributed significantly to suicide attempts in multivariate analysis (OR=145.3 and OR=37.9). None of our patients died.\u0000Conclusions: Preventing both poisoning and suicide attempts is the most critical priority. However, we suggest prevention strategies should be strengthened even if mortality is not observed. Furthermore, our study shows that suicide attempts are very likely to be repeated, especially if an underlying psychiatric illness exists.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81858033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Although the pathophysiology of coronary slow flow is not fully understood, evidence suggesting endothelial dysfunction and subclinical widespread atherosclerosis in genesis has grown in recent years. Our aim in this study is to investigate the relationship between uric acid/ albumin ratio and coronary slow flow. Methods: One hundred and five coronary slow flow patients (determined by the Thrombolysis in Myocardial Infarction-frame count method) and one-hundred patients with normal coronary low were included retrospectively. The uric acid/ albumin ratio was investigated in all patients participating. Results: In the logistic regression analysis, it was revealed that high uric acid levels, uric acid/ albumin ratios, and male gender were independent predictors for coronary slow flow. Among these parameters, the uric acid/ albumin ratio was the best predictor of coronary slow flow. Based on the receiver operating characteristics (ROC) analysis, the cut-off value of uric acid/ albumin ratio ≥ 0.57 was found to predict coronary slow flow with 68.3% sensitivity and 68.7% specificity. In multivariate logistic regression analysis, high uric acid levels (OR: 2.22; 95% CI (1.551-3.200), p < 0.001), high serum uric acid/ albumin ratio (OR: 37.7 95% CI (8.176-234.387), p < 0.001), male gender (OR: 0.157; 95% CI (0.078-0.318), p < 0.001) were independent predictors of coronary slow flow. Conclusions: High uric acid/ albumin ratio was detected as an independent predictor for coronary slow flow. Larger studies are needed to elucidate its role in the pathophysiology of coronary slow flow.
目的:尽管冠状动脉慢血流的病理生理机制尚不完全清楚，但近年来有越来越多的证据表明内皮功能障碍和亚临床广泛的动脉粥样硬化的发生。本研究的目的是探讨尿酸/白蛋白比值与冠状动脉慢血流的关系。方法:回顾性分析105例冠状动脉慢血流患者(采用心肌梗死溶栓-框架计数法测定)和100例正常冠状动脉低血流患者。对所有患者的尿酸/白蛋白比值进行了调查。结果:在logistic回归分析中，高尿酸水平、尿酸/白蛋白比和男性是冠状动脉慢血流的独立预测因素。在这些参数中，尿酸/白蛋白比是冠状动脉慢血流的最佳预测指标。根据受试者工作特征(ROC)分析，尿酸/白蛋白比值≥0.57的临界值预测冠状动脉慢血流的敏感性为68.3%，特异性为68.7%。在多因素logistic回归分析中，高尿酸水平(OR: 2.22;95% CI (1.551-3.200)， p < 0.001)，高血尿酸/白蛋白比(OR: 37.7 95% CI (8.176-234.387)， p < 0.001)，男性(OR: 0.157;95% CI (0.078-0.318)， p < 0.001)是冠状动脉慢血流的独立预测因子。结论:高尿酸/白蛋白比值可作为冠状动脉慢血流的独立预测因子。需要更大规模的研究来阐明其在冠状动脉慢血流病理生理中的作用。
{"title":"Relationship between uric acid/ albumin ratio and coronary slow flow","authors":"A. Demirkıran, C. Aydın","doi":"10.18621/eurj.1340527","DOIUrl":"https://doi.org/10.18621/eurj.1340527","url":null,"abstract":"Objectives: Although the pathophysiology of coronary slow flow is not fully understood, evidence suggesting endothelial dysfunction and subclinical widespread atherosclerosis in genesis has grown in recent years. Our aim in this study is to investigate the relationship between uric acid/ albumin ratio and coronary slow flow. \u0000Methods: One hundred and five coronary slow flow patients (determined by the Thrombolysis in Myocardial Infarction-frame count method) and one-hundred patients with normal coronary low were included retrospectively. The uric acid/ albumin ratio was investigated in all patients participating. \u0000Results: In the logistic regression analysis, it was revealed that high uric acid levels, uric acid/ albumin ratios, and male gender were independent predictors for coronary slow flow. Among these parameters, the uric acid/ albumin ratio was the best predictor of coronary slow flow. Based on the receiver operating characteristics (ROC) analysis, the cut-off value of uric acid/ albumin ratio ≥ 0.57 was found to predict coronary slow flow with 68.3% sensitivity and 68.7% specificity. In multivariate logistic regression analysis, high uric acid levels (OR: 2.22; 95% CI (1.551-3.200), p < 0.001), high serum uric acid/ albumin ratio (OR: 37.7 95% CI (8.176-234.387), p < 0.001), male gender (OR: 0.157; 95% CI (0.078-0.318), p < 0.001) were independent predictors of coronary slow flow. \u0000Conclusions: High uric acid/ albumin ratio was detected as an independent predictor for coronary slow flow. Larger studies are needed to elucidate its role in the pathophysiology of coronary slow flow.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88753602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Dibekoğlu, E. Bora, Ebru Eroğlu, G. Yurtsever, Y. Uyanikgil, O. Erbaş
Objectives: This experimental study investigated the preventive effects of Celecoxib, a selective COX-2 inhibitor, on lung injury induced by intra-abdominal sepsis in rats. The study assessed Celecoxib's potential to mitigate the harmful impacts of sepsis on lung tissue. Methods: Thirty male Wistar albino rats, divided into three groups: a normal control group, a sepsis-induced group treated with saline, and a sepsis-induced group treated with Celecoxib. Sepsis was induced using fecal intraperitoneal injection (FIP), followed by a one-hour administration of Celecoxib at 50 mg/kg/day to the treatment group. Biochemical analysis of lung tissue measured oxidative stress markers (malondialdehyde [MDA]) and pro-inflammatory cytokines (Tumor Necrosis Faftor-α [TNF-α]). Histopathological examination evaluated lung tissue damage, encompassing alveolar congestion, hemorrhage, inflammatory cell aggregation, and edema. Arterial blood gas analysis quantified partial oxygen (PaO2) and carbon dioxide (PaCO2) pressures. Results: Celecoxib-treated rats exhibited reduced oxidative stress markers with lower MDA levels, indicating decreased oxidative damage in lung tissue. Moreover, TNF-α and other pro-inflammatory cytokines were significantly reduced in lung tissues of Celecoxib-treated rats, indicating its anti-inflammatory effects. Histopathological examination revealed reduced lung tissue damage in Celecoxib-treated rats, including alveolar congestion, hemorrhage, and inflammatory cell aggregation. Arterial blood gas analysis showed improved oxygenation (PaO2) in the Celecoxib-treated group compared to untreated sepsis rats. Conclusions: Celecoxib demonstrated preventive effects against sepsis-induced lung injury in rats by mitigating oxidative stress and inflammation, thereby preserving lung tissue integrity—further research, including clinical trials, to validate its effectiveness and safety in human sepsis management.
{"title":"Effect of celecoxib on intra-abdominal sepsis-induced lung injury in rats","authors":"C. Dibekoğlu, E. Bora, Ebru Eroğlu, G. Yurtsever, Y. Uyanikgil, O. Erbaş","doi":"10.18621/eurj.1333071","DOIUrl":"https://doi.org/10.18621/eurj.1333071","url":null,"abstract":"Objectives: This experimental study investigated the preventive effects of Celecoxib, a selective COX-2 inhibitor, on lung injury induced by intra-abdominal sepsis in rats. The study assessed Celecoxib's potential to mitigate the harmful impacts of sepsis on lung tissue. \u0000Methods: Thirty male Wistar albino rats, divided into three groups: a normal control group, a sepsis-induced group treated with saline, and a sepsis-induced group treated with Celecoxib. Sepsis was induced using fecal intraperitoneal injection (FIP), followed by a one-hour administration of Celecoxib at 50 mg/kg/day to the treatment group. Biochemical analysis of lung tissue measured oxidative stress markers (malondialdehyde [MDA]) and pro-inflammatory cytokines (Tumor Necrosis Faftor-α [TNF-α]). Histopathological examination evaluated lung tissue damage, encompassing alveolar congestion, hemorrhage, inflammatory cell aggregation, and edema. Arterial blood gas analysis quantified partial oxygen (PaO2) and carbon dioxide (PaCO2) pressures.\u0000Results: Celecoxib-treated rats exhibited reduced oxidative stress markers with lower MDA levels, indicating decreased oxidative damage in lung tissue. Moreover, TNF-α and other pro-inflammatory cytokines were significantly reduced in lung tissues of Celecoxib-treated rats, indicating its anti-inflammatory effects. Histopathological examination revealed reduced lung tissue damage in Celecoxib-treated rats, including alveolar congestion, hemorrhage, and inflammatory cell aggregation. Arterial blood gas analysis showed improved oxygenation (PaO2) in the Celecoxib-treated group compared to untreated sepsis rats.\u0000Conclusions: Celecoxib demonstrated preventive effects against sepsis-induced lung injury in rats by mitigating oxidative stress and inflammation, thereby preserving lung tissue integrity—further research, including clinical trials, to validate its effectiveness and safety in human sepsis management.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77571925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cevat Rifat Cündübey, Mehmet Ak, M. Demir, Şeyma DAĞLITUNCEZDİ ÇAM
Objectives: To investigate the frequency of cord entanglement and neonatal outcomes in vaginal deliveries. Methods: A total of 24,623 patients who had vaginal delivery at at Kayseri City Hospital between July 2018 and January 2023 were included in the study. The incidence of nuchal cord was determined in the study group. The characteristics and perinatal outcomes of groups with and without nuchal cord were compared. Chi-square test was used for statistical evaluation. A p value less than 0.05 was considered significant in the evaluation. Results: The rate of cord entanglement in the neck at birth was 15.7%. There was no statistically significant difference between the infant weights, genders, maternal ages, hospitalization rates in the neonatal intensive care unit, and apgar scores at the 1st and 5th minutes of the babies included in the study. We detected amniotic fluid with meconium in 506 (13.1%) patients with a nuchal cord and 270 (1.3%) without a nuchal cord, and the difference was found to be significant. Conclusions: There is no significant relationship between vaginal deliveries with the nuchal cord and poor perinatal outcomes, except for meconium amniotic fluid. For this reason, pregnant women diagnosed with nuchal cord in the third trimester can deliver vaginally, but they should be carefully monitored in terms of meconium and related complications. However, neonates with nuchal cord do not have significantly longer neonatal hospital stays, and thus the adverse effects of nuchal cord may be transient.
{"title":"Exploring the impacts of a nuchal cord on perinatal outcomes in vaginal delivery","authors":"Cevat Rifat Cündübey, Mehmet Ak, M. Demir, Şeyma DAĞLITUNCEZDİ ÇAM","doi":"10.18621/eurj.1310253","DOIUrl":"https://doi.org/10.18621/eurj.1310253","url":null,"abstract":"Objectives: To investigate the frequency of cord entanglement and neonatal outcomes in vaginal deliveries.\u0000Methods: A total of 24,623 patients who had vaginal delivery at at Kayseri City Hospital between July 2018 and January 2023 were included in the study. The incidence of nuchal cord was determined in the study group. The characteristics and perinatal outcomes of groups with and without nuchal cord were compared. Chi-square test was used for statistical evaluation. A p value less than 0.05 was considered significant in the evaluation.\u0000Results: The rate of cord entanglement in the neck at birth was 15.7%. There was no statistically significant difference between the infant weights, genders, maternal ages, hospitalization rates in the neonatal intensive care unit, and apgar scores at the 1st and 5th minutes of the babies included in the study. We detected amniotic fluid with meconium in 506 (13.1%) patients with a nuchal cord and 270 (1.3%) without a nuchal cord, and the difference was found to be significant. \u0000Conclusions: There is no significant relationship between vaginal deliveries with the nuchal cord and poor perinatal outcomes, except for meconium amniotic fluid. For this reason, pregnant women diagnosed with nuchal cord in the third trimester can deliver vaginally, but they should be carefully monitored in terms of meconium and related complications. However, neonates with nuchal cord do not have significantly longer neonatal hospital stays, and thus the adverse effects of nuchal cord may be transient.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86681341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Bıcılıoğlu, Tuğçe Nalbant, Alper Çiçek, Esin Ergönül, G. Gökalp, G. Demir, Ş. Bardak, E. Berksoy
Objectives: We aimed to identify biochemical markers and clinical findings with high sensitivity and specificity that can be used in the differential diagnosis of patients suspected of having Multisystem Inflammatory Syndrome in Children (MISC) in the pediatric emergency department (PED). Moreover, we also examined early warning signs for predicting severe MIS-C patients requiring admission to intensive care unit (ICU). Methods: We conducted a retrospective analysis of patients presenting to the PED with suspected MIS-C. Patient records were assessed for initial complaints, physical examination findings, laboratory and ımaging test results, diagnoses, and follow-up plans. Patients diagnosed with MIS-C were categorized as the MIS-C group, while others were categorized as the non-MIS-C group. Comparisons were made between these two groups. Results: A total of 266 patients were included, with 68 diagnosed with COVID-19-associated MIS-C, including 20 monitored in the pediatric ICU. MIS-C patients had higher mean age, hospitalization, and ICU admission rates compared to non-MIS-C. MIS-C group showed higher prevalence of respiratory symptoms, hematological involvement, and shock. We observed lymphopenia, thrombocytopenia, hyponatremia, and elevated levels of blood C-reactive protein (CRP), procalcitonin, triglycerides, troponin, Brain Natriuretic Peptide (BNP), D-dimer, and fibrinogen in the MIS-C group. ICU patients had higher procalcitonin, aspartate aminotransferase, alanine aminotransferase, triglycerides, troponin, BNP, and ferritin levels, and lower sodium levels. Conclusions: COVID-19-associated MIS-C group had higher rates of respiratory symptoms, hematological involvement, and shock. Lymphopenia, thrombocytopenia, elevated CRP, and D-dimer can guide MIS-C differential diagnosis. Additional tests (procalcitonin, troponin, BNP, triglycerides, ferritin) are recommended for high-suspicion cases. Patients with elevated BNP levels may require ICU admission.
{"title":"Differential diagnosis for multiple systemic inflammatory syndrome in children: clinical and laboratory clues","authors":"Y. Bıcılıoğlu, Tuğçe Nalbant, Alper Çiçek, Esin Ergönül, G. Gökalp, G. Demir, Ş. Bardak, E. Berksoy","doi":"10.18621/eurj.1238842","DOIUrl":"https://doi.org/10.18621/eurj.1238842","url":null,"abstract":"Objectives: We aimed to identify biochemical markers and clinical findings with high sensitivity and specificity that can be used in the differential diagnosis of patients suspected of having Multisystem Inflammatory Syndrome in Children (MISC) in the pediatric emergency department (PED). Moreover, we also examined early warning signs for predicting severe MIS-C patients requiring admission to intensive care unit (ICU).\u0000Methods: We conducted a retrospective analysis of patients presenting to the PED with suspected MIS-C. Patient records were assessed for initial complaints, physical examination findings, laboratory and ımaging test results, diagnoses, and follow-up plans. Patients diagnosed with MIS-C were categorized as the MIS-C group, while others were categorized as the non-MIS-C group. Comparisons were made between these two groups.\u0000Results: A total of 266 patients were included, with 68 diagnosed with COVID-19-associated MIS-C, including 20 monitored in the pediatric ICU. MIS-C patients had higher mean age, hospitalization, and ICU admission rates compared to non-MIS-C. MIS-C group showed higher prevalence of respiratory symptoms, hematological involvement, and shock. We observed lymphopenia, thrombocytopenia, hyponatremia, and elevated levels of blood C-reactive protein (CRP), procalcitonin, triglycerides, troponin, Brain Natriuretic Peptide (BNP), D-dimer, and fibrinogen in the MIS-C group. ICU patients had higher procalcitonin, aspartate aminotransferase, alanine aminotransferase, triglycerides, troponin, BNP, and ferritin levels, and lower sodium levels.\u0000Conclusions: COVID-19-associated MIS-C group had higher rates of respiratory symptoms, hematological involvement, and shock. Lymphopenia, thrombocytopenia, elevated CRP, and D-dimer can guide MIS-C differential diagnosis. Additional tests (procalcitonin, troponin, BNP, triglycerides, ferritin) are recommended for high-suspicion cases. Patients with elevated BNP levels may require ICU admission.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76144330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: To investigate the differences between the characteristics of disease presentation and treatment outcomes on the basis of gender in patients with operated prolactinoma. Methods: Prolactinoma patients who underwent endoscopic transsphenoidal surgery at Istanbul University-Cerrahpasa, Neurosurgery clinics between 2013-2023 were included in this study. Surgical indications, secondary treatments, clinical, demographic, biochemical, radiological findings, and pathological data were analyzed. Data were compared between the gender groups. Results: Thirty-two men and 28 women were included in the study. The mean age of the men was 44 years and that of the women was 29 years. While men were more likely to have decreased libido, women were more likely to have menstrual irregularities (p < 0.001). The tumor was larger in men (p = 0.001), presenting with a more frequent suprasellar invasion (p = 0.001) and cavernous sinus invasion (p < 0.001). Pituitary hormone deficiency (p < 0.001) and visual field defects (p < 0.001) occurred more frequently in men. Conclusions: Male prolactinoma patients tend to have more invasive and larger tumors. Men are less likely than women to go into remission with surgery. This difference in presentation may be due to indistinct symptoms in male patients and late diagnosis.
{"title":"Evaluation of the gender effect in operated prolactinomas","authors":"Dilan Özaydin, A. N. Demir, N. Tanrıöver","doi":"10.18621/eurj.1340508","DOIUrl":"https://doi.org/10.18621/eurj.1340508","url":null,"abstract":"Objectives: To investigate the differences between the characteristics of disease presentation and treatment outcomes on the basis of gender in patients with operated prolactinoma.\u0000Methods: Prolactinoma patients who underwent endoscopic transsphenoidal surgery at Istanbul University-Cerrahpasa, Neurosurgery clinics between 2013-2023 were included in this study. Surgical indications, secondary treatments, clinical, demographic, biochemical, radiological findings, and pathological data were analyzed. Data were compared between the gender groups. \u0000Results: Thirty-two men and 28 women were included in the study. The mean age of the men was 44 years and that of the women was 29 years. While men were more likely to have decreased libido, women were more likely to have menstrual irregularities (p < 0.001). The tumor was larger in men (p = 0.001), presenting with a more frequent suprasellar invasion (p = 0.001) and cavernous sinus invasion (p < 0.001). Pituitary hormone deficiency (p < 0.001) and visual field defects (p < 0.001) occurred more frequently in men.\u0000Conclusions: Male prolactinoma patients tend to have more invasive and larger tumors. Men are less likely than women to go into remission with surgery. This difference in presentation may be due to indistinct symptoms in male patients and late diagnosis.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74687526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: The shock index (SI) and its derivatives play a crucial role in rapid prognosis and risk assessment, particularly in emergent scenarios like ST-segment elevation myocardial infarction (STEMI). Methods: This study was conducted as a single-centered retrospective. A total of 467 cases that met the study criteria with a confirmed STEMI diagnosis were included. The SI, modified SI (MSI), age SI (ASI), and age-modified SI (AMSI) scores of the cases were calculated and compared. In this study, p 0.05 was accepted as the statistical significance level. Results: Calculated scores were compared among cases meeting STEMI criteria. Mortal cases displayed significantly higher SI, MSI, ASI, and AMSI, as well as elevated heart rates and lowered SBP, DBP, and MAP values. ASI exhibited the highest predictive success for mortality (AUC: 0.802), followed by AMSI (AUC: 0.798). AMSI demonstrated superior significance in estimating major adverse cardiovascular events (MACE) (p < 0.001 for each parameter). Conclusions: ASI proved most effective in gauging mortality risk, while AMSI excelled in predicting MACE risk among SI derivatives. These indices hold promise for guiding patient triage and emergency care in STEMI cases, owing to their simplicity and predictive capacity.
{"title":"Evaluation of the success of shock index and its derivatives in determining mortality in STEMI cases applied to emergency department","authors":"G. Yurtsever, A. Çakır, E. Bora","doi":"10.18621/eurj.1340926","DOIUrl":"https://doi.org/10.18621/eurj.1340926","url":null,"abstract":"Objectives: The shock index (SI) and its derivatives play a crucial role in rapid prognosis and risk assessment, particularly in emergent scenarios like ST-segment elevation myocardial infarction (STEMI).\u0000Methods: This study was conducted as a single-centered retrospective. A total of 467 cases that met the study criteria with a confirmed STEMI diagnosis were included. The SI, modified SI (MSI), age SI (ASI), and age-modified SI (AMSI) scores of the cases were calculated and compared. In this study, p 0.05 was accepted as the statistical significance level.\u0000Results: Calculated scores were compared among cases meeting STEMI criteria. Mortal cases displayed significantly higher SI, MSI, ASI, and AMSI, as well as elevated heart rates and lowered SBP, DBP, and MAP values. ASI exhibited the highest predictive success for mortality (AUC: 0.802), followed by AMSI (AUC: 0.798). AMSI demonstrated superior significance in estimating major adverse cardiovascular events (MACE) (p < 0.001 for each parameter).\u0000Conclusions: ASI proved most effective in gauging mortality risk, while AMSI excelled in predicting MACE risk among SI derivatives. These indices hold promise for guiding patient triage and emergency care in STEMI cases, owing to their simplicity and predictive capacity.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"70 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77253769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perforations after endoscopic retrograde colangiopancreatography (ERCP) are divided into four types. Type 1 refers to the duodenum, type 2 the periampullary region, type 3 the bile duct itself, and type 4 the observation of retroperitoneal free air on cross-sectional imaging. The treatment of type 2 biliary perforations remains debatable. We present a patient who was successfully treated with a self-expandable metal stent (SEMS) without the need for surgery or any complications.
{"title":"Type 2 biliary perforation successfully managed with early insertion of self-expandable metal stent","authors":"Idris Kurt","doi":"10.18621/eurj.1256002","DOIUrl":"https://doi.org/10.18621/eurj.1256002","url":null,"abstract":"Perforations after endoscopic retrograde colangiopancreatography (ERCP) are divided into four types. Type 1 refers to the duodenum, type 2 the periampullary region, type 3 the bile duct itself, and type 4 the observation of retroperitoneal free air on cross-sectional imaging. The treatment of type 2 biliary perforations remains debatable. We present a patient who was successfully treated with a self-expandable metal stent (SEMS) without the need for surgery or any complications.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85067858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cuneyt Arikan, O. Çınaroğlu, M. Efgan, Efe Kanter, E. Bora
Objectives: Encephalitis and meningitis can have serious and potentially life-threatening consequences. This study aims to investigate whether the effects of systemic immune inflammation index (SII) and neutrophil/lymphocyte (N/L) ratio on differential diagnosis, severity, and clinical outcomes are superior to each other in patients diagnosed with encephalitis and meningitis in the emergency department. Methods: Patients aged 18 years and older who presented to the adult emergency department of the hospital and were diagnosed with meningitis or encephalitis between January and December 2022 were included in the study. Patients under 18 and those with missing data in their files were excluded from the study. N/L ratio, SII values, and other associated parameters were compared between the group with mortality and the group who survived both diseases. Results: There were significant differences in neutrophil, lymphocyte, N/L ratio, SII, and C-reactive protein (CRP) values between meningitis and encephalitis patients. N/L ratio and SII values were significantly lower in encephalitis patients than in meningitis patients. There was no significant difference in any of the parameters between surviving and deceased patients. Conclusions: Simple calculable ratios such as SII and N/L ratio can be a supportive parameter in the differential diagnosis of the disease. However, it has been observed that using these indices is not a useful tool in determining the severity and prognosis of patients with encephalitis and meningitis.
{"title":"A new adjunct in the differentiation of encephalitis and meningitis after negative cerebrospinal fluid culture: systemic inflammatory immune index","authors":"Cuneyt Arikan, O. Çınaroğlu, M. Efgan, Efe Kanter, E. Bora","doi":"10.18621/eurj.1297700","DOIUrl":"https://doi.org/10.18621/eurj.1297700","url":null,"abstract":"Objectives: Encephalitis and meningitis can have serious and potentially life-threatening consequences. This study aims to investigate whether the effects of systemic immune inflammation index (SII) and neutrophil/lymphocyte (N/L) ratio on differential diagnosis, severity, and clinical outcomes are superior to each other in patients diagnosed with encephalitis and meningitis in the emergency department.\u0000Methods: Patients aged 18 years and older who presented to the adult emergency department of the hospital and were diagnosed with meningitis or encephalitis between January and December 2022 were included in the study. Patients under 18 and those with missing data in their files were excluded from the study. N/L ratio, SII values, and other associated parameters were compared between the group with mortality and the group who survived both diseases.\u0000Results: There were significant differences in neutrophil, lymphocyte, N/L ratio, SII, and C-reactive protein (CRP) values between meningitis and encephalitis patients. N/L ratio and SII values were significantly lower in encephalitis patients than in meningitis patients. There was no significant difference in any of the parameters between surviving and deceased patients.\u0000Conclusions: Simple calculable ratios such as SII and N/L ratio can be a supportive parameter in the differential diagnosis of the disease. However, it has been observed that using these indices is not a useful tool in determining the severity and prognosis of patients with encephalitis and meningitis.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73499951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
İ. Büyükceran, Hikmet Çinka, Alparslan Yurtbay, H. Coskun, A. Yildirim, D. Keski̇n
Objectives: Treatment of acromioclavicular joint dislocations vary. In this study, we aim to examine the functional results of patients who underwent hook plate fixation due to dislocation of acromioclavicular joint. Methods: We retrospectively observed 21 patients who had been treated with hook plate due to dislocation of acromioclavicular joint. At follow up, Constant-Murley scoring system was performed for shoulder function evaluation, while radiological results were performed by X-ray. Results: Seventeen of these patients were male and four were female. Eleven of these patients had Rockwood type 5 joint dislocation and ten had Rockwood type 3 joint dislocation. The mean age was 36.7 ± 13.37 years (range: 19-61 years). The mean follow-up period was 27.3 ± 19.3 months (range: 10-59). Constant-Murley shoulder scoring was excellent in 18 patients (93.6) and good (82.5) in 3 patients. While one patient had wound site infection and one patient had plate broken, no one had any neurological damage. Except for the failed implants, plate removal was not performed because the patients did not have plate-related complaints. At follow-up, it was observed that the acromioclavicular joint was in the reduced position on direct radiographs. Conclusions: We observed good clinical and functional results for the treatment of acromioclavicular joint dislocation with hook plate treatment. The hook plate method is a safe and effective method in the acute treatment of type 3-5 injuries according to the Rockwood classification.
{"title":"Clinical evaluation of treatment with hook plate in patients with acromioclavicular joint dislocation","authors":"İ. Büyükceran, Hikmet Çinka, Alparslan Yurtbay, H. Coskun, A. Yildirim, D. Keski̇n","doi":"10.18621/eurj.1278637","DOIUrl":"https://doi.org/10.18621/eurj.1278637","url":null,"abstract":"Objectives: Treatment of acromioclavicular joint dislocations vary. In this study, we aim to examine the functional results of patients who underwent hook plate fixation due to dislocation of acromioclavicular joint.\u0000Methods: We retrospectively observed 21 patients who had been treated with hook plate due to dislocation of acromioclavicular joint. At follow up, Constant-Murley scoring system was performed for shoulder function evaluation, while radiological results were performed by X-ray.\u0000Results: Seventeen of these patients were male and four were female. Eleven of these patients had Rockwood type 5 joint dislocation and ten had Rockwood type 3 joint dislocation. The mean age was 36.7 ± 13.37 years (range: 19-61 years). The mean follow-up period was 27.3 ± 19.3 months (range: 10-59). Constant-Murley shoulder scoring was excellent in 18 patients (93.6) and good (82.5) in 3 patients. While one patient had wound site infection and one patient had plate broken, no one had any neurological damage. Except for the failed implants, plate removal was not performed because the patients did not have plate-related complaints. At follow-up, it was observed that the acromioclavicular joint was in the reduced position on direct radiographs.\u0000Conclusions: We observed good clinical and functional results for the treatment of acromioclavicular joint dislocation with hook plate treatment. The hook plate method is a safe and effective method in the acute treatment of type 3-5 injuries according to the Rockwood classification.","PeriodicalId":22571,"journal":{"name":"The European Research Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89348495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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