Mahsa Zarei, H. Du, A. Nassar, Rachel E Yan, K. Giannikou, Sneha Johnson, H. Lam, E. Henske, Yubao Wang, Tinghu Zhang, J. Asara, D. Kwiatkowski
Tuberous sclerosis complex (TSC) is a genetic disorder in which tumors develop due to TSC1/TSC2 loss and activation of mTORC1. Zarei et al. show that TSC tumors are sensitive to CDK7 inhibition, which reduces expression of NRF2 and glutathione synthetic genes, leading to glutathione depletion and ROS-mediated cell death.
{"title":"Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion","authors":"Mahsa Zarei, H. Du, A. Nassar, Rachel E Yan, K. Giannikou, Sneha Johnson, H. Lam, E. Henske, Yubao Wang, Tinghu Zhang, J. Asara, D. Kwiatkowski","doi":"10.1084/jem.20190251","DOIUrl":"https://doi.org/10.1084/jem.20190251","url":null,"abstract":"Tuberous sclerosis complex (TSC) is a genetic disorder in which tumors develop due to TSC1/TSC2 loss and activation of mTORC1. Zarei et al. show that TSC tumors are sensitive to CDK7 inhibition, which reduces expression of NRF2 and glutathione synthetic genes, leading to glutathione depletion and ROS-mediated cell death.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"216 1","pages":"2635 - 2652"},"PeriodicalIF":0.0,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75371534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anne R Albright, J. Kabat, Moyi Li, Fiona Raso, A. Reboldi, J. Muppidi
GCs are polarized into LZ and DZ to allow for the spatial separation of selection and proliferation. In this study, we describe the previously unknown function of TGFβ in promoting the transition of GCBs from LZ to DZ.
{"title":"TGFβ signaling in germinal center B cells promotes the transition from light zone to dark zone","authors":"Anne R Albright, J. Kabat, Moyi Li, Fiona Raso, A. Reboldi, J. Muppidi","doi":"10.1084/jem.20181868","DOIUrl":"https://doi.org/10.1084/jem.20181868","url":null,"abstract":"GCs are polarized into LZ and DZ to allow for the spatial separation of selection and proliferation. In this study, we describe the previously unknown function of TGFβ in promoting the transition of GCBs from LZ to DZ.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"238 1 1","pages":"2531 - 2545"},"PeriodicalIF":0.0,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72948921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Delphine Ohayon, Alessia De Chiara, P. M. Dang, N. Thieblemont, Simon M. Chatfield, V. Marzaioli, S. S. Burgener, Julie Mocek, C. Candalh, Coralie Pintard, P. Tacnet-Delorme, G. Renault, I. Lagoutte, M. Favier, Francine Walker, M. Hurtado-Nedelec, D. Desplancq, E. Weiss, C. Benarafa, D. Housset, J. Marie, P. Frachet, J. El-Benna, V. Witko-Sarsat
This study describes a novel function of cytosolic proliferating cell nuclear antigen (PCNA) in the control of neutrophil NADPH oxidase, a complex pivotal for ROS generation in inflammation. Inhibition of neutrophil PCNA results in a potent antiinflammatory effect in colitis.
{"title":"Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils","authors":"Delphine Ohayon, Alessia De Chiara, P. M. Dang, N. Thieblemont, Simon M. Chatfield, V. Marzaioli, S. S. Burgener, Julie Mocek, C. Candalh, Coralie Pintard, P. Tacnet-Delorme, G. Renault, I. Lagoutte, M. Favier, Francine Walker, M. Hurtado-Nedelec, D. Desplancq, E. Weiss, C. Benarafa, D. Housset, J. Marie, P. Frachet, J. El-Benna, V. Witko-Sarsat","doi":"10.1084/jem.20180371","DOIUrl":"https://doi.org/10.1084/jem.20180371","url":null,"abstract":"This study describes a novel function of cytosolic proliferating cell nuclear antigen (PCNA) in the control of neutrophil NADPH oxidase, a complex pivotal for ROS generation in inflammation. Inhibition of neutrophil PCNA results in a potent antiinflammatory effect in colitis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"38 1","pages":"2669 - 2687"},"PeriodicalIF":0.0,"publicationDate":"2019-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86832147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liat Stoler-Barak, Adi Biram, Natalia Davidzohn, Y. Addadi, O. Golani, Ziv Shulman
Antibody-mediated long-lasting protection from harmful pathogens depends on collaboration of immune cells within immunological niches. Stoler-Barak et al. introduce an approach that enables the visualization of all the germinal center niches and activated B cells within intact lymph nodes.
{"title":"B cell dissemination patterns during the germinal center reaction revealed by whole-organ imaging","authors":"Liat Stoler-Barak, Adi Biram, Natalia Davidzohn, Y. Addadi, O. Golani, Ziv Shulman","doi":"10.1084/jem.20190789","DOIUrl":"https://doi.org/10.1084/jem.20190789","url":null,"abstract":"Antibody-mediated long-lasting protection from harmful pathogens depends on collaboration of immune cells within immunological niches. Stoler-Barak et al. introduce an approach that enables the visualization of all the germinal center niches and activated B cells within intact lymph nodes.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"90 1","pages":"2515 - 2530"},"PeriodicalIF":0.0,"publicationDate":"2019-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79401777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hunter S. Futch, Karen N. McFarland, Brenda D. Moore, M. Zino Kuhn, B. Giasson, Thomas B. Ladd, Karen A. Scott, Melanie R. Shapiro, Rachel L. Nosacka, Marshall S. Goodwin, Yong Ran, Pedro E. Cruz, Daniel H. Ryu, Cara L. Croft, Yona Levites, C. Janus, Paramita Chakrabarty, Andrew R. Judge, T. Brusko, A. D. de Kloet, E. Krause, T. Golde
A high-affinity monoclonal antibody (CTRND05) targeting corticotropin-releasing factor (CRF) blocks stress-induced corticosterone increases, counteracts effects of chronic variable stress, and induces other phenotypes consistent with suppression of the HPA axis.
{"title":"An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes","authors":"Hunter S. Futch, Karen N. McFarland, Brenda D. Moore, M. Zino Kuhn, B. Giasson, Thomas B. Ladd, Karen A. Scott, Melanie R. Shapiro, Rachel L. Nosacka, Marshall S. Goodwin, Yong Ran, Pedro E. Cruz, Daniel H. Ryu, Cara L. Croft, Yona Levites, C. Janus, Paramita Chakrabarty, Andrew R. Judge, T. Brusko, A. D. de Kloet, E. Krause, T. Golde","doi":"10.1084/jem.20190430","DOIUrl":"https://doi.org/10.1084/jem.20190430","url":null,"abstract":"A high-affinity monoclonal antibody (CTRND05) targeting corticotropin-releasing factor (CRF) blocks stress-induced corticosterone increases, counteracts effects of chronic variable stress, and induces other phenotypes consistent with suppression of the HPA axis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"43 1","pages":"2479 - 2491"},"PeriodicalIF":0.0,"publicationDate":"2019-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78956950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sheng Li, Yuqing Wu, Dongxue Yang, Chunyan Wu, Chunmei Ma, Xue Liu, P. Moynagh, Bingwei Wang, G. Hu, Shuo Yang
In this study, Li et al. demonstrate that gasdermin D in peripheral myeloid cells promotes the activation and differentiation of T cell in the secondary lymphoid organs, thus driving T cell–mediated neuroinflammation and demyelination in the CNS of EAE mice.
{"title":"Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis","authors":"Sheng Li, Yuqing Wu, Dongxue Yang, Chunyan Wu, Chunmei Ma, Xue Liu, P. Moynagh, Bingwei Wang, G. Hu, Shuo Yang","doi":"10.1084/jem.20190377","DOIUrl":"https://doi.org/10.1084/jem.20190377","url":null,"abstract":"In this study, Li et al. demonstrate that gasdermin D in peripheral myeloid cells promotes the activation and differentiation of T cell in the secondary lymphoid organs, thus driving T cell–mediated neuroinflammation and demyelination in the CNS of EAE mice.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"119 1","pages":"2562 - 2581"},"PeriodicalIF":0.0,"publicationDate":"2019-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85635338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-08-26DOI: 10.1084/jem.2018076508222019C
Qing-cui Gao, Zong-Yuan Yang, Sen Xu, Xiaoting Li, Xin Yang, P. Jin, Yi Liu, Xiaoshui Zhou, Taoran Zhang, Cheng Gong, Xiao Wei, Dan Liu, Chaoyang Sun, Gang Chen, Junbo Hu, L. Meng, Jianfeng Zhou, Kenjiro Sawada, R. Fruscio, T. Grunt, J. Wischhusen, V. Vargas-Hernández, B. Pothuri, R. Coleman
2448 https://doi.org/10.1084/jem.20180765 J. Exp. Med. 2019 Vol. 216 No. 1
{"title":"Correction: Heterotypic CAF-tumor spheroids promote early peritoneal metastatis of ovarian cancer","authors":"Qing-cui Gao, Zong-Yuan Yang, Sen Xu, Xiaoting Li, Xin Yang, P. Jin, Yi Liu, Xiaoshui Zhou, Taoran Zhang, Cheng Gong, Xiao Wei, Dan Liu, Chaoyang Sun, Gang Chen, Junbo Hu, L. Meng, Jianfeng Zhou, Kenjiro Sawada, R. Fruscio, T. Grunt, J. Wischhusen, V. Vargas-Hernández, B. Pothuri, R. Coleman","doi":"10.1084/jem.2018076508222019C","DOIUrl":"https://doi.org/10.1084/jem.2018076508222019C","url":null,"abstract":"2448 https://doi.org/10.1084/jem.20180765 J. Exp. Med. 2019 Vol. 216 No. 1","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"45 1","pages":"2448 - 2448"},"PeriodicalIF":0.0,"publicationDate":"2019-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78805933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ross Levine: Focus on the critical questions","authors":"S. Houston","doi":"10.1084/jem.20191484","DOIUrl":"https://doi.org/10.1084/jem.20191484","url":null,"abstract":"Ross Levine: Focus on the critical questions","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"46 1","pages":"1967 - 1968"},"PeriodicalIF":0.0,"publicationDate":"2019-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75998412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benyu Liu, Liuliu Yang, Xiaoxiao Zhu, Huimu Li, P. Zhu, Jiayi Wu, Tiankun Lu, Luyun He, Nian Liu, Shu Meng, Liang Zhou, B. Ye, Yong Tian, Z. Fan
Liu et al. show that Yeats4 recruits the Dot1l–RNA Pol II complex onto the Lmo4 promoter by recognizing H3K27ac modification to initiate Lmo4 transcription in α4β7+ CLPs, leading to ILC lineage commitment.
Liu等人的研究表明，yeat4通过识别H3K27ac修饰，将Dot1l-RNA Pol II复合物招募到Lmo4启动子上，启动α4β7+ CLPs中的Lmo4转录，从而导致ILC谱系承诺。
{"title":"Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription","authors":"Benyu Liu, Liuliu Yang, Xiaoxiao Zhu, Huimu Li, P. Zhu, Jiayi Wu, Tiankun Lu, Luyun He, Nian Liu, Shu Meng, Liang Zhou, B. Ye, Yong Tian, Z. Fan","doi":"10.1084/jem.20182363","DOIUrl":"https://doi.org/10.1084/jem.20182363","url":null,"abstract":"Liu et al. show that Yeats4 recruits the Dot1l–RNA Pol II complex onto the Lmo4 promoter by recognizing H3K27ac modification to initiate Lmo4 transcription in α4β7+ CLPs, leading to ILC lineage commitment.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"64 1","pages":"2653 - 2668"},"PeriodicalIF":0.0,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83309123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joana K Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz M Abad, B. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, M. Johansson, G. Hansson, G. Birchenough
It is thought that the Nlrp6 inflammasome regulates formation of the inner mucus layer (IML) barrier that prohibits contact between the microbiota and colonic epithelial cells. Using microbiota-controlled mice and combined ex vivo/in vivo IML analytical approaches, Volk et al. delineate the relative roles of the inflammasome and microbiota in shaping IML formation and function.
{"title":"The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function","authors":"Joana K Volk, Elisabeth E. L. Nyström, Sjoerd van der Post, Beatriz M Abad, B. Schroeder, Åsa Johansson, Frida Svensson, Sofia Jäverfelt, M. Johansson, G. Hansson, G. Birchenough","doi":"10.1084/jem.20190679","DOIUrl":"https://doi.org/10.1084/jem.20190679","url":null,"abstract":"It is thought that the Nlrp6 inflammasome regulates formation of the inner mucus layer (IML) barrier that prohibits contact between the microbiota and colonic epithelial cells. Using microbiota-controlled mice and combined ex vivo/in vivo IML analytical approaches, Volk et al. delineate the relative roles of the inflammasome and microbiota in shaping IML formation and function.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"10 26 1","pages":"2602 - 2618"},"PeriodicalIF":0.0,"publicationDate":"2019-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90197733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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