This review discusses the growing literature on the pathogenic role of IL-17 in cancer, focusing on recent studies that place IL-17 as a nexus linking inflammation, tissue repair, and cancer.
{"title":"The role of interleukin-17 in tumor development and progression","authors":"Junjie Zhao, Xing Chen, T. Herjan, Xiaoxia Li","doi":"10.1084/jem.20190297","DOIUrl":"https://doi.org/10.1084/jem.20190297","url":null,"abstract":"This review discusses the growing literature on the pathogenic role of IL-17 in cancer, focusing on recent studies that place IL-17 as a nexus linking inflammation, tissue repair, and cancer.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85312447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. F. du Pre, Jana Blaževski, Alisa E. Dewan, J. Stamnaes, Chakravarthi Kanduri, G. K. Sandve, M. K. Johannesen, Christian B Lindstad, Kathrin Hnida, L. Fugger, G. Melino, Shuo-Wang Qiao, L. Sollid
This study sheds light on the mechanism by which autoantibodies to transglutaminase 2 (TG2) are formed in celiac disease. The authors find that there is no deletion or silencing of autoreactive TG2-specific B cells and that production of anti-TG2 autoantibodies is controlled by T cell help.
{"title":"B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2","authors":"M. F. du Pre, Jana Blaževski, Alisa E. Dewan, J. Stamnaes, Chakravarthi Kanduri, G. K. Sandve, M. K. Johannesen, Christian B Lindstad, Kathrin Hnida, L. Fugger, G. Melino, Shuo-Wang Qiao, L. Sollid","doi":"10.1084/jem.20190860","DOIUrl":"https://doi.org/10.1084/jem.20190860","url":null,"abstract":"This study sheds light on the mechanism by which autoantibodies to transglutaminase 2 (TG2) are formed in celiac disease. The authors find that there is no deletion or silencing of autoreactive TG2-specific B cells and that production of anti-TG2 autoantibodies is controlled by T cell help.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79588894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
IL-17 plays versatile roles during tumorigenesis. Here, Vitiello and Miller summarize current knowledge in harnessing IL-17–producing γδ and Th17 cells for successful cancer immunotherapy.
{"title":"Targeting the interleukin-17 immune axis for cancer immunotherapy","authors":"G. Vitiello, G. Miller","doi":"10.1084/jem.20190456","DOIUrl":"https://doi.org/10.1084/jem.20190456","url":null,"abstract":"IL-17 plays versatile roles during tumorigenesis. Here, Vitiello and Miller summarize current knowledge in harnessing IL-17–producing γδ and Th17 cells for successful cancer immunotherapy.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74064434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This review summarizes the steps from basic research on IL-17 family cytokines to understanding their role in psoriasis pathogenesis to the approval of a number of monoclonal antibodies targeting IL-17 pathways as first line treatment of psoriasis and psoriatic arthritis.
{"title":"Interleukin-17 cytokines: Effectors and targets in psoriasis—A breakthrough in understanding and treatment","authors":"I. Prinz, I. Sandrock, U. Mrowietz","doi":"10.1084/jem.20191397","DOIUrl":"https://doi.org/10.1084/jem.20191397","url":null,"abstract":"This review summarizes the steps from basic research on IL-17 family cytokines to understanding their role in psoriasis pathogenesis to the approval of a number of monoclonal antibodies targeting IL-17 pathways as first line treatment of psoriasis and psoriatic arthritis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81608228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although many chronic inflammatory diseases share the feature of elevated IL-17 production, therapeutic targeting of IL-17 has vastly different clinical outcomes. Here the authors summarize the recent progress in understanding the protective and pathogenic role of the IL-23/IL-17 axis in preclinical models and human inflammatory diseases.
{"title":"Targeting interleukin-17 in chronic inflammatory disease: A clinical perspective","authors":"P. Zwicky, S. Unger, B. Becher","doi":"10.1084/jem.20191123","DOIUrl":"https://doi.org/10.1084/jem.20191123","url":null,"abstract":"Although many chronic inflammatory diseases share the feature of elevated IL-17 production, therapeutic targeting of IL-17 has vastly different clinical outcomes. Here the authors summarize the recent progress in understanding the protective and pathogenic role of the IL-23/IL-17 axis in preclinical models and human inflammatory diseases.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86986746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xingrong Du, H. Zeng, Shaofeng Liu, C. Guy, Yogesh Dhungana, G. Neale, M. Bergo, H. Chi
Thymocyte egress is a critical determinant of T cell homeostasis and adaptive immunity. Du et al. describe unexpected roles of mevalonate metabolism–fueled protein geranylgeranylation, but not farnesylation, in driving thymocyte egress through modulating Cdc42 and Pak activities.
{"title":"Mevalonate metabolism–dependent protein geranylgeranylation regulates thymocyte egress","authors":"Xingrong Du, H. Zeng, Shaofeng Liu, C. Guy, Yogesh Dhungana, G. Neale, M. Bergo, H. Chi","doi":"10.1084/jem.20190969","DOIUrl":"https://doi.org/10.1084/jem.20190969","url":null,"abstract":"Thymocyte egress is a critical determinant of T cell homeostasis and adaptive immunity. Du et al. describe unexpected roles of mevalonate metabolism–fueled protein geranylgeranylation, but not farnesylation, in driving thymocyte egress through modulating Cdc42 and Pak activities.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87255288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Tanaka, H. Nishikawa, Shinsuke Noguchi, D. Sugiyama, Hiromasa Morikawa, Yoshiko Takeuchi, D. Ha, Naoya Shigeta, T. Kitawaki, Y. Maeda, Takuro Saito, Yoshinori Shinohara, Y. Kameoka, K. Iwaisako, F. Monma, K. Ohishi, J. Karbach, E. Jäger, K. Sawada, N. Katayama, N. Takahashi, S. Sakaguchi
As a novel type of anticancer reagent, imatinib inhibits not only BCR-ABL oncogenic protein but also LCK in T cells as an off-target, being able to selectively deplete mature T reg cells and thereby evoke effective immune responses to various cancers.
{"title":"Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells","authors":"A. Tanaka, H. Nishikawa, Shinsuke Noguchi, D. Sugiyama, Hiromasa Morikawa, Yoshiko Takeuchi, D. Ha, Naoya Shigeta, T. Kitawaki, Y. Maeda, Takuro Saito, Yoshinori Shinohara, Y. Kameoka, K. Iwaisako, F. Monma, K. Ohishi, J. Karbach, E. Jäger, K. Sawada, N. Katayama, N. Takahashi, S. Sakaguchi","doi":"10.1084/jem.20191009","DOIUrl":"https://doi.org/10.1084/jem.20191009","url":null,"abstract":"As a novel type of anticancer reagent, imatinib inhibits not only BCR-ABL oncogenic protein but also LCK in T cells as an off-target, being able to selectively deplete mature T reg cells and thereby evoke effective immune responses to various cancers.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79815893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhen Xiong, P. Xia, Xiaoxiao Zhu, Jingjing Geng, Shuo Wang, B. Ye, Xiwen Qin, Yuan Qu, Luyun He, Dongdong Fan, Ying Du, Yong Tian, Z. Fan
Xiong et al. show that CCP3 performs deglutamylation of BAP1 to stabilize BAP1, which eliminates H2AK119Ub from Hoxa1 promoter and initiates Hoxa1 expression, leading to enhanced HSC self-renewal.
{"title":"Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis","authors":"Zhen Xiong, P. Xia, Xiaoxiao Zhu, Jingjing Geng, Shuo Wang, B. Ye, Xiwen Qin, Yuan Qu, Luyun He, Dongdong Fan, Ying Du, Yong Tian, Z. Fan","doi":"10.1084/jem.20190974","DOIUrl":"https://doi.org/10.1084/jem.20190974","url":null,"abstract":"Xiong et al. show that CCP3 performs deglutamylation of BAP1 to stabilize BAP1, which eliminates H2AK119Ub from Hoxa1 promoter and initiates Hoxa1 expression, leading to enhanced HSC self-renewal.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86640986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jennifer K. Bando, S. Gilfillan, B. Di Luccia, J. L. Fachi, Cristiane Sécca, M. Cella, M. Colonna
This study shows that the regulatory innate lymphoid cell (ILCreg), a recently described IL-10–producing innate lymphocyte, is not present in mice bred in four different facilities. Instead, group 2 ILCs provide an inducible source of IL-10 in the intestine.
{"title":"ILC2s are the predominant source of intestinal ILC-derived IL-10","authors":"Jennifer K. Bando, S. Gilfillan, B. Di Luccia, J. L. Fachi, Cristiane Sécca, M. Cella, M. Colonna","doi":"10.1084/jem.20191520","DOIUrl":"https://doi.org/10.1084/jem.20191520","url":null,"abstract":"This study shows that the regulatory innate lymphoid cell (ILCreg), a recently described IL-10–producing innate lymphocyte, is not present in mice bred in four different facilities. Instead, group 2 ILCs provide an inducible source of IL-10 in the intestine.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73830756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiuxiu Liu, Lin Yang, Ling-Xiao Shao, Yang He, Gang Wu, Y. Bao, Nan-nan Lu, Dong-Mei Gong, Yangyang Lu, Tian-Tian Cui, Ninghe Sun, Dan-yang Chen, W. Shi, K. Fukunaga, Hong-Shan Chen, Zhong Chen, Feng Han, Ying-Mei Lu
Liu et al. reveal a key mechanism that mediating the transition from cerebrovascular damage to epilepsy. They identify the endothelial cyclin-dependent kinase 5 (CDK5) regulates astrocytic glutamate reuptake and increased glutamate synaptic function through CXCL1/CXCR2-mediated astrogliosis.
{"title":"Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis","authors":"Xiuxiu Liu, Lin Yang, Ling-Xiao Shao, Yang He, Gang Wu, Y. Bao, Nan-nan Lu, Dong-Mei Gong, Yangyang Lu, Tian-Tian Cui, Ninghe Sun, Dan-yang Chen, W. Shi, K. Fukunaga, Hong-Shan Chen, Zhong Chen, Feng Han, Ying-Mei Lu","doi":"10.1084/jem.20180992","DOIUrl":"https://doi.org/10.1084/jem.20180992","url":null,"abstract":"Liu et al. reveal a key mechanism that mediating the transition from cerebrovascular damage to epilepsy. They identify the endothelial cyclin-dependent kinase 5 (CDK5) regulates astrocytic glutamate reuptake and increased glutamate synaptic function through CXCL1/CXCR2-mediated astrogliosis.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78339048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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