Akio Takezaki, S. Tsukumo, Y. Setoguchi, J. Ledford, H. Goto, K. Hosomichi, H. Uehara, Y. Nishioka, K. Yasutomo
We identify a homozygous mutation in SFTPA1 in patients with idiopathic pulmonary fibrosis (IPF). The mutation causes increased necroptosis of type II alveolar epithelial cells through the IRE1α–JNK axis, which highlights the necroptosis pathway as a therapeutic target for IPF.
{"title":"A homozygous SFTPA1 mutation drives necroptosis of type II alveolar epithelial cells in patients with idiopathic pulmonary fibrosis","authors":"Akio Takezaki, S. Tsukumo, Y. Setoguchi, J. Ledford, H. Goto, K. Hosomichi, H. Uehara, Y. Nishioka, K. Yasutomo","doi":"10.1084/jem.20182351","DOIUrl":"https://doi.org/10.1084/jem.20182351","url":null,"abstract":"We identify a homozygous mutation in SFTPA1 in patients with idiopathic pulmonary fibrosis (IPF). The mutation causes increased necroptosis of type II alveolar epithelial cells through the IRE1α–JNK axis, which highlights the necroptosis pathway as a therapeutic target for IPF.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"59 1","pages":"2724 - 2735"},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80602377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. B. Moeller, Irina Leonardi, A. Schlosser, A. Flamar, N. Bessman, G. Putzel, T. Thomsen, Mark A. Hammond, C. S. Jepsen, K. Skjødt, E. Füchtbauer, D. Farber, G. Sørensen, I. Iliev, U. Holmskov, D. Artis
In the present study, Moeller et al. identify a previously unrecognized pathway through which intestinal epithelial cells expressing the novel chitin-binding receptor FIBCD1 can recognize and control intestinal fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.
{"title":"Modulation of the fungal mycobiome is regulated by the chitin-binding receptor FIBCD1","authors":"J. B. Moeller, Irina Leonardi, A. Schlosser, A. Flamar, N. Bessman, G. Putzel, T. Thomsen, Mark A. Hammond, C. S. Jepsen, K. Skjødt, E. Füchtbauer, D. Farber, G. Sørensen, I. Iliev, U. Holmskov, D. Artis","doi":"10.1084/jem.20182244","DOIUrl":"https://doi.org/10.1084/jem.20182244","url":null,"abstract":"In the present study, Moeller et al. identify a previously unrecognized pathway through which intestinal epithelial cells expressing the novel chitin-binding receptor FIBCD1 can recognize and control intestinal fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"4 1","pages":"2689 - 2700"},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90540898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Shi, Melissa Manis, J. Long, Kairuo Wang, P. Sullivan, Javier Remolina Serrano, Rosa Hoyle, D. Holtzman
Shi et al. find that microglia, instead of tau-induced direct neurotoxicity, are the driving force of neurodegeneration in a tauopathy mouse model. Microglia are also required for tau pathogenesis. In addition, apoE strongly regulates neurodegeneration in the setting of tauopathy predominantly by modulating microglial function.
{"title":"Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model","authors":"Yang Shi, Melissa Manis, J. Long, Kairuo Wang, P. Sullivan, Javier Remolina Serrano, Rosa Hoyle, D. Holtzman","doi":"10.1084/jem.20190980","DOIUrl":"https://doi.org/10.1084/jem.20190980","url":null,"abstract":"Shi et al. find that microglia, instead of tau-induced direct neurotoxicity, are the driving force of neurodegeneration in a tauopathy mouse model. Microglia are also required for tau pathogenesis. In addition, apoE strongly regulates neurodegeneration in the setting of tauopathy predominantly by modulating microglial function.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"280 1","pages":"2546 - 2561"},"PeriodicalIF":0.0,"publicationDate":"2019-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89900988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Takamura, Shigeki Kato, Chihiro Motozono, T. Shimaoka, S. Ueha, K. Matsuo, Kosuke Miyauchi, Tomoko Masumoto, Asami Katsushima, T. Nakayama, M. Tomura, K. Matsushima, M. Kubo, M. Miyazawa
Tissue-resident lung memory CD8+ TRM cells in the lung interstitium and airways are compartmentally separated from TEM cells, and lung airway TRM cells are primarily maintained by the continuous seeding of cells from the lung interstitium.
{"title":"Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung","authors":"S. Takamura, Shigeki Kato, Chihiro Motozono, T. Shimaoka, S. Ueha, K. Matsuo, Kosuke Miyauchi, Tomoko Masumoto, Asami Katsushima, T. Nakayama, M. Tomura, K. Matsushima, M. Kubo, M. Miyazawa","doi":"10.1084/jem.20190557","DOIUrl":"https://doi.org/10.1084/jem.20190557","url":null,"abstract":"Tissue-resident lung memory CD8+ TRM cells in the lung interstitium and airways are compartmentally separated from TEM cells, and lung airway TRM cells are primarily maintained by the continuous seeding of cells from the lung interstitium.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"11 1","pages":"2736 - 2747"},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81468621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander N. Wein, S. McMaster, S. Takamura, P. Dunbar, Emily K. Cartwright, Sarah L. Hayward, Daniel T McManus, T. Shimaoka, S. Ueha, T. Tsukui, Tomoko Masumoto, M. Kurachi, K. Matsushima, J. Kohlmeier
Lung TRM cells are present in both the interstitium and airways, but factors regulating their localization to these distinct sites are unknown. This work shows that the CXCR6/CXCL16 axis governs the partitioning of TRM cells to different compartments of the lung and maintains the airway TRM cell pool.
{"title":"CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways","authors":"Alexander N. Wein, S. McMaster, S. Takamura, P. Dunbar, Emily K. Cartwright, Sarah L. Hayward, Daniel T McManus, T. Shimaoka, S. Ueha, T. Tsukui, Tomoko Masumoto, M. Kurachi, K. Matsushima, J. Kohlmeier","doi":"10.1084/jem.20181308","DOIUrl":"https://doi.org/10.1084/jem.20181308","url":null,"abstract":"Lung TRM cells are present in both the interstitium and airways, but factors regulating their localization to these distinct sites are unknown. This work shows that the CXCR6/CXCL16 axis governs the partitioning of TRM cells to different compartments of the lung and maintains the airway TRM cell pool.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"1999 1","pages":"2748 - 2762"},"PeriodicalIF":0.0,"publicationDate":"2019-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78111487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pyroptosis is an important component of the innate immune system. Gasdermin D, the mediator of pyroptosis, has been shown to be crucial for optimal defense against microbial infection. In this review, the authors discuss gasdermin D and its role in disease.
{"title":"Gasdermins and their role in immunity and inflammation","authors":"Pontus Orning, E. Lien, K. Fitzgerald","doi":"10.1084/jem.20190545","DOIUrl":"https://doi.org/10.1084/jem.20190545","url":null,"abstract":"Pyroptosis is an important component of the innate immune system. Gasdermin D, the mediator of pyroptosis, has been shown to be crucial for optimal defense against microbial infection. In this review, the authors discuss gasdermin D and its role in disease.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"15 1","pages":"2453 - 2465"},"PeriodicalIF":0.0,"publicationDate":"2019-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87584802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Knipfer, A. Schulz-Kuhnt, Markus Kindermann, Vicky Greif, C. Symowski, D. Voehringer, M. Neurath, I. Atreya, S. Wirtz
Knipfer et al. identify a critical role for the type 2–related chemokine receptor CCR8 on ILC2 functions during type 2 immune responses. CCR8 supports ILC2 survival by autocrine secretion of the ligand CCL1. The authors demonstrate that CCL1/CCR8 signaling protects against helminth infections.
{"title":"A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2–mediated inflammation","authors":"L. Knipfer, A. Schulz-Kuhnt, Markus Kindermann, Vicky Greif, C. Symowski, D. Voehringer, M. Neurath, I. Atreya, S. Wirtz","doi":"10.1084/jem.20182111","DOIUrl":"https://doi.org/10.1084/jem.20182111","url":null,"abstract":"Knipfer et al. identify a critical role for the type 2–related chemokine receptor CCR8 on ILC2 functions during type 2 immune responses. CCR8 supports ILC2 survival by autocrine secretion of the ligand CCL1. The authors demonstrate that CCL1/CCR8 signaling protects against helminth infections.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"4 1","pages":"2763 - 2777"},"PeriodicalIF":0.0,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90318525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akihiro Tokunaga, D. Sugiyama, Y. Maeda, A. B. Warner, K. Panageas, S. Ito, Y. Togashi, Chika Sakai, J. Wolchok, H. Nishikawa
Corticosteroids inhibit antitumor immune responses of immune checkpoint blockade in a dose- and timing-dependent manner. Memory CD8+ T cells with low TCR affinity are selectively suppressed by corticosteroids, necessitating careful and thoughtful corticosteroid use.
{"title":"Selective inhibition of low-affinity memory CD8+ T cells by corticosteroids","authors":"Akihiro Tokunaga, D. Sugiyama, Y. Maeda, A. B. Warner, K. Panageas, S. Ito, Y. Togashi, Chika Sakai, J. Wolchok, H. Nishikawa","doi":"10.1084/jem.20190738","DOIUrl":"https://doi.org/10.1084/jem.20190738","url":null,"abstract":"Corticosteroids inhibit antitumor immune responses of immune checkpoint blockade in a dose- and timing-dependent manner. Memory CD8+ T cells with low TCR affinity are selectively suppressed by corticosteroids, necessitating careful and thoughtful corticosteroid use.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"25 1","pages":"2701 - 2713"},"PeriodicalIF":0.0,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85445607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rémy Rodriguez, B. Fournier, D. J. Cordeiro, Sarah Winter, K. Izawa, Emmanuel Martin, D. Boutboul, C. Lenoir, S. Fraitag, S. Kracker, T. Watts, C. Picard, J. Bruneau, I. Callebaut, A. Fischer, B. Neven, S. Latour
Identification of biallelic loss-of-function mutations in TNFRSF9 and PIK3CD in a kindred with chronic active Epstein-Barr virus infection of T cells (CAEBV) suggests that CAEBV is the consequence of factors providing growth advantage to EBV-infected T cells combined with defective cell immunity toward EBV-infected cells.
{"title":"Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells","authors":"Rémy Rodriguez, B. Fournier, D. J. Cordeiro, Sarah Winter, K. Izawa, Emmanuel Martin, D. Boutboul, C. Lenoir, S. Fraitag, S. Kracker, T. Watts, C. Picard, J. Bruneau, I. Callebaut, A. Fischer, B. Neven, S. Latour","doi":"10.1084/jem.20190678","DOIUrl":"https://doi.org/10.1084/jem.20190678","url":null,"abstract":"Identification of biallelic loss-of-function mutations in TNFRSF9 and PIK3CD in a kindred with chronic active Epstein-Barr virus infection of T cells (CAEBV) suggests that CAEBV is the consequence of factors providing growth advantage to EBV-infected T cells combined with defective cell immunity toward EBV-infected cells.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"75 1","pages":"2800 - 2818"},"PeriodicalIF":0.0,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89597218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiang Sun, Yu Cui, Haiyun Feng, Haifeng Liu, Xiaolong Liu
How DNA methylation–mediated repression is reversed before Foxp3 transcription is unclear. Here, Sun et al. show that the epigenetic regulator Uhrf1, which maintained Foxp3 methylation, is down-regulated by TGF-β signaling and provide novel insight into the epigenetic regulation of Foxp3 during iT reg cell differentiation.
{"title":"TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity","authors":"Xiang Sun, Yu Cui, Haiyun Feng, Haifeng Liu, Xiaolong Liu","doi":"10.1084/jem.20190550","DOIUrl":"https://doi.org/10.1084/jem.20190550","url":null,"abstract":"How DNA methylation–mediated repression is reversed before Foxp3 transcription is unclear. Here, Sun et al. show that the epigenetic regulator Uhrf1, which maintained Foxp3 methylation, is down-regulated by TGF-β signaling and provide novel insight into the epigenetic regulation of Foxp3 during iT reg cell differentiation.","PeriodicalId":23015,"journal":{"name":"The Tokushima journal of experimental medicine","volume":"29 1","pages":"2819 - 2837"},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77790057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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