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Urethral tissue characterization using multiparametric ultrasound imaging 利用多参数超声成像鉴定尿道组织特征。
IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2024-09-26 DOI: 10.1016/j.ultras.2024.107481
Haowei Tai , Kourosh Kalayeh , James A. Ashton-Miller , John O. DeLancey , J. Brian Fowlkes
<div><div>A decrease in urethral closure pressure is one of the primary causes of stress urinary incontinence in women. Atrophy of the urethral muscles is a primary factor in the 15 % age-related decline in urethral closure pressure per decade. Incontinence not only affects the well-being of women but is also a leading cause of nursing home admission. The objective of this research was to develop a noninvasive test to assess urethral tissue microenvironmental changes using multiparametric ultrasound (mpUS) imaging technique. Transperineal B-scan ultrasound (US) data were captured using clinical scanners equipped with curvilinear or linear transducers. Imaging was performed on volunteers from our institution medical center (n = 15, 22 to 76 y.o.) during Valsalva maneuvers. After expert delineation of the region of interest in each frame, the central axis of the urethra was automatically defined to determine the angle between the urethra and the US beam for further analysis. By integrating angle-dependent backscatter with radiomic texture feature analysis, a mpUS technique was developed to identify biomarkers that reflect subtle microstructural changes expected within the urethral tissue. The process was repeated when the urethra and US beam were at a fixed angle. Texture selection was conducted for both angle-dependent and angle-independent results to remove redundancies. Ultimately, a distinct biomarker was derived using a random forest regression model to compute the urethra score based on features selected from both processes. Angle-dependent backscatter analysis shows that the calculated slope of US mean image intensity decreased by 0.89 (±0.31) % annually, consistent with the expected atrophic disorganization of urethral tissue structure and the associated reduction in urethral closure pressure with age. Additionally, textural analysis performed at a specific angle (i.e., 40 degrees) revealed changes in gray level nonuniformity, skewness, and correlation by 0.08 (±0.04) %, −2.16 (±1.14) %, and −0.32 (±0.35) % per year, respectively. The urethra score was ultimately determined by combining data selected from both angle-dependent and angle-independent analysis strategies using a random forest regression model with age, yielding an R<sup>2</sup> value of 0.96 and a p-value less than 0.001. The proposed mpUS tissue characterization technique not only holds promise for guiding future urethral tissue characterization studies without the need for tissue biopsies or invasive functional testing but also aims to minimize observer-induced variability. By leveraging mpUS imaging strategies that account for angle dependence, it provides more accurate assessments. Notably, the urethra score, calculated from US images that reflect tissue microstructural changes, serves as a potential biomarker providing clinicians with deeper insight into urethral tissue function and may aid in diagnosing and managing related conditions while helping to determine the causes
尿道闭合压下降是导致女性压力性尿失禁的主要原因之一。尿道肌肉萎缩是导致尿道闭合压力每十年下降 15% 的主要因素。尿失禁不仅影响妇女的健康,也是导致妇女入住疗养院的主要原因。这项研究的目的是利用多参数超声(mpUS)成像技术,开发一种评估尿道组织微环境变化的无创检测方法。经会阴 B-scan 超声波(US)数据由配备曲线或线性换能器的临床扫描仪采集。本机构医疗中心的志愿者(n = 15,22 至 76 岁)在做瓦尔萨尔瓦动作时进行了成像。在专家对每帧图像中的感兴趣区进行划定后,自动定义尿道的中心轴,以确定尿道与 US 光束之间的角度,从而进行进一步分析。通过将角度依赖性反向散射与放射学纹理特征分析相结合,开发出了一种 mpUS 技术,用于识别反映尿道组织内预期微观结构变化的生物标记物。当尿道和 US 光束呈固定角度时,重复这一过程。对与角度相关和与角度无关的结果都进行了纹理选择,以去除冗余。最终,使用随机森林回归模型,根据从两个过程中选择的特征计算尿道得分,得出了一个独特的生物标记。与角度相关的反向散射分析表明,US 平均图像强度的计算斜率每年下降 0.89 (±0.31) %,这与预期的尿道组织结构萎缩紊乱以及随着年龄增长尿道闭合压力的降低是一致的。此外,以特定角度(即 40 度)进行的纹理分析显示,灰度不均匀度、偏斜度和相关性每年分别变化 0.08 (±0.04) %、-2.16 (±1.14) % 和 -0.32 (±0.35) %。尿道评分最终是通过使用年龄随机森林回归模型结合从角度依赖性和角度无关性分析策略中选取的数据确定的,R2 值为 0.96,P 值小于 0.001。所提出的 mpUS 组织特征描述技术不仅有望指导未来的尿道组织特征描述研究,而无需进行组织活检或侵入性功能测试,而且还能最大限度地减少观察者引起的变异。通过利用考虑角度依赖性的 mpUS 成像策略,它能提供更准确的评估。值得注意的是,根据反映组织微观结构变化的 US 图像计算出的尿道评分是一种潜在的生物标志物,可让临床医生更深入地了解尿道组织的功能,有助于诊断和处理相关疾病,同时帮助确定尿失禁的原因。
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引用次数: 0
Velocity of ultrasound diffusion in heterogeneous media and its applications 超声波在异质介质中的扩散速度及其应用
IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2024-09-24 DOI: 10.1016/j.ultras.2024.107476
Jin-Yeon Kim
This paper investigates the velocity of ultrasonic diffusion in heterogeneous media under the conditions where the diffuse wave approximation is valid (λa). The diffusion velocity is defined as the moving speed of the peak of the energy evolution curve. The peak arrival time as a function of transport distance is calculated for infinite spaces and bounded domains. The results show that the peak arrival time is independent of the domain’s geometry, i.e. the size, shape, and boundary conditions. This is confirmed by comparing the arrival times in an infinite space and a bounded domain with a geometric feature – a surface-breaking crack of varying depth. Therefore, the velocity of ultrasonic diffusion is an intrinsic property of a medium, and the formula for the infinite three-dimensional space is sufficient to calculate the arrival time–transport distance relationship, given the diffuse properties of the medium. These findings eliminate the needs for the finite element numerical simulations in the applications to determine geometric parameters such as the crack depth using diffuse ultrasound. The diffusion velocity is a function of transport distance in general, while its far-field asymptotic value is constant regardless of the dimensionality and geometry of the domain.
本文研究了在扩散波近似有效(λ≤a)的条件下,超声波在异质介质中的扩散速度。扩散速度定义为能量演化曲线峰值的移动速度。计算了无限空间和有界域中峰值到达时间与传输距离的函数关系。结果表明,峰值到达时间与域的几何形状(即大小、形状和边界条件)无关。通过比较无限空间和有界域的到达时间,以及几何特征--深度不等的表面破裂裂缝--证实了这一点。因此,超声波扩散速度是介质的固有特性,在介质具有扩散特性的情况下,无限三维空间的公式足以计算出到达时间与传输距离之间的关系。在利用扩散超声波确定裂纹深度等几何参数的应用中,这些发现消除了有限元数值模拟的需要。一般来说,扩散速度是传输距离的函数,而其远场渐近值是恒定的,与域的尺寸和几何形状无关。
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引用次数: 0
Cubic nonlinearity and surface shock waves in soft tissue-like materials 类软组织材料中的立方非线性和表面冲击波
IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2024-09-19 DOI: 10.1016/j.ultras.2024.107469
Héctor Alarcón , Belfor Galaz , David Espíndola
The cubic nonlinearity of shear wave propagation plays a significant role in brain injury biomechanics. However, soft materials, like the brain, also support the propagation of surface waves, which produce a combination of longitudinal and transverse deformation. The order of the nonlinearity of surface waves in soft materials is still unknown. Here, we directly observe nonlinear Scholte waves propagating in an interface formed by an incompressible gelatin tissue-mimicking phantom and a water layer using ultrasound imaging operated as fast as 16667 frames per second. A two-dimensional correlation-based tracking algorithm was utilized to extract movies of the movement produced by the surface wave. Our results show that the initially nearly monochromatic wave becomes progressively distorted with the propagation due to nonlinearity. The distortion of the wave and its frequency spectrum indicate a high content of odd harmonics when compared with even harmonics. Additionally, by fitting our experimental data to a minimalist one-dimensional model based on the wave speed variation as a function of the perturbation amplitude, we found a cubic nonlinear parameter 46 times larger than the quadratic nonlinear parameter. Overall, the wave distortion, the harmonic development, and the dependence of the wave speed with the amplitude prove that cubic nonlinearity is essential to modeling nonlinear Scholte wave propagation.
剪切波传播的立方非线性在脑损伤生物力学中起着重要作用。然而,像大脑这样的软材料也支持表面波的传播,表面波会产生纵向和横向变形。软材料中表面波的非线性阶次仍然未知。在这里,我们利用每秒高达 16667 帧的超声波成像技术,直接观察了在不可压缩的明胶组织模拟模型和水层形成的界面中传播的非线性肖尔特波。我们利用基于二维相关性的跟踪算法来提取表面波运动的视频。我们的研究结果表明,由于非线性原因,最初近乎单色的波在传播过程中逐渐失真。波的畸变及其频谱表明,与偶次谐波相比,奇次谐波的含量较高。此外,通过将实验数据拟合到基于波速变化与扰动振幅函数关系的极简一维模型中,我们发现三次非线性参数比二次非线性参数大 46 倍。总之,波的畸变、谐波发展以及波速与振幅的关系证明,三次非线性对于非线性肖尔特波传播建模至关重要。
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引用次数: 0
High-Intensity focused ultrasound linear array and system for dermatology treatment 用于皮肤病治疗的高强度聚焦超声线性阵列和系统
IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2024-09-19 DOI: 10.1016/j.ultras.2024.107477
Juhwan Kim , Jinwoo Kim , Duk Kyu Lee , Eui-Ji Shin , Jin Ho Chang
Dermatological lesions are typically located just a few millimeters below the surface of the skin, which constrains the efficacy of optical-based therapeutic methods such as photothermal and photodynamic therapy due to limited therapeutic depth caused by optical scattering. As an alternative, high-intensity focused ultrasound (HIFU) has been explored for its potential to treat a variety of dermatological conditions because it offers greater flexibility in terms of treatment depth. Since dermatological lesions have a small thickness ranging from 1.5 to 2.0 mm, high-frequency ultrasound (3–10 MHz or higher) is preferred as the focal area is proportional to the operating frequency. However, due to the difficulty in fabricating HIFU array transducers at this frequency range, the majority of HIFU treatments for dermatology rely on single element transducers. Despite the advantages of HIFU, single-element-based HIFU systems are limited in prevalent use for dermatology treatment due to their fixed focal length and mechanical movement for treatment, which can be time-consuming and unsuitable for treating multiple lesions. To address this, we present a newly developed HIFU linear array and 128-channel driving electronics specifically designed for dermatology treatment. This array consists of 128 elements, has a center frequency of 3.7 MHz, an elevation focal length of 28 mm, and an F-number of 1.27 in the elevation direction. The array has a footprint of 71.6 mm by 22 mm. Experiments using a tissue-mimicking phantom have demonstrated that the HIFU linear array and system are capable of transmitting sufficient ultrasound energy to create coagulation inside the phantom.
皮肤病的病灶通常位于皮肤表面下几毫米处,这就限制了光热疗法和光动力疗法等基于光学的治疗方法的疗效,因为光学散射导致治疗深度有限。作为一种替代方法,高强度聚焦超声(HIFU)因其在治疗深度方面具有更大的灵活性,已被用于治疗各种皮肤病。由于皮肤病变的厚度较小,从 1.5 毫米到 2.0 毫米不等,因此首选高频超声(3-10 兆赫或更高),因为病灶面积与工作频率成正比。然而,由于在这一频率范围内很难制造 HIFU 阵列换能器,皮肤科的大多数 HIFU 治疗都依赖于单元件换能器。尽管 HIFU 有很多优点,但基于单元件的 HIFU 系统在皮肤科治疗中的普遍应用受到限制,因为它们的焦距固定,治疗时需要机械运动,既费时又不适合治疗多处病变。为了解决这个问题,我们提出了一种新开发的 HIFU 线性阵列和 128 通道驱动电子设备,专为皮肤病治疗而设计。该阵列由 128 个元件组成,中心频率为 3.7 MHz,仰角焦距为 28 mm,仰角方向的 F 值为 1.27。阵列占地面积为 71.6 毫米 x 22 毫米。使用组织模拟模型进行的实验表明,HIFU 线性阵列和系统能够传输足够的超声能量,在模型内部产生凝固作用。
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引用次数: 0
Blind zone defect imaging using multipath edge-reflected Lamb waves 利用多径边缘反射λ波进行盲区缺陷成像
IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2024-09-19 DOI: 10.1016/j.ultras.2024.107473
Nan Zhang , Caibin Xu , Liang Zeng , Mingxi Deng
This paper proposed a Lamb wave-based defect imaging method with multipath edge reflections, which can detect the crack-like defect in blind zones that is invisible for the conventional delay-and-sum algorithm. In the implementation process, mirror points of transducers with respect to all the four plate edges are firstly introduced as extra virtual transmitters and receivers. By assuming the defect position, all of the potential traveling paths of edge-reflected wave packets can be next traced. Considering it is always possible to find a matching path for a certain wave packet from these traced ones if there is really a defect at the assumed place, a damage index is thus established to estimate whether the assumption holds true. Based on that, the detection area can be imaged by altering the assumed defect position, calculating its index, and taking the index as pixel value. Subsequently, wave packets of different orders from various signals are also used to generate the corresponding images. A multiplication strategy is finally adopted to fuse all the results and eliminate the artifacts. In this manner, the final image of the detection area can be obtained. Both numerical and experimental cases have been carried out to prove the effectiveness and feasibility of the proposed method. Results show that it can locate through-thickness cracks in different blind zones accurately, and the minimum relative error of these cases is only 1.12%.
本文提出了一种具有多径边缘反射的基于λ波的缺陷成像方法,该方法可检测出传统延迟求和算法无法检测到的盲区裂纹状缺陷。在实现过程中,首先引入相对于所有四个板边缘的换能器镜像点作为额外的虚拟发射器和接收器。通过假定缺陷位置,接下来就可以追踪边缘反射波包的所有潜在行进路径。考虑到如果在假定位置确实存在缺陷,则总是有可能从这些路径中找到与某个波包相匹配的路径,因此建立了一个损坏指数来估计假定是否成立。在此基础上,通过改变假定的缺陷位置、计算其指数并将指数作为像素值,就可以对检测区域进行成像。随后,各种信号的不同阶数波包也被用来生成相应的图像。最后采用乘法策略来融合所有结果并消除伪影。通过这种方式,可以得到检测区域的最终图像。为了证明所提方法的有效性和可行性,我们进行了数值计算和实验。结果表明,该方法可以准确定位不同盲区中的贯通裂缝,其最小相对误差仅为 1.12%。
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引用次数: 0
Reconfigurable ultrasound focusing effect through acoustic barriers 通过声屏障实现可重构的超声聚焦效应
IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2024-09-17 DOI: 10.1016/j.ultras.2024.107470
Ming Ma , He Gao, Xinze Guo , Zhongqing Su
The low transmission efficiency of ultrasonic waves in waveguides of a high acoustic impedance (referred to as dense materials), due to the impedance mismatch between the background media and the dense materials, poses a significant obstacle to practical applications of high-intensity focused ultrasound (HIFU) such as ultrasound therapy or medical imaging. To address this challenge, we present an inverse optimization scheme for fabrication of novel acoustic meta-lenses, enabling strengthened penetration and enhanced focusing of ultrasonic waves when the waves traverse barriers. Both simulation and experiment validate the effectiveness of the developed meta-lenses which are annexed to hemispherical plates, and demonstrate an enhanced transmission of the sound power by an order of magnitude compared to a scenario without the use of the meta-lens. The focal distance is reconfigurable by adjusting the geometric parameters of the meta-lenses. The proposed design philosophy is not restricted by the complexity of the target structures, and it allows the ultrasonic waves to pass through acoustic barriers with a non-uniform thickness yet maintaining efficient wave focusing. This study holds appealing applications in HIFU-enabled ultrasound imaging and therapy.
由于背景介质和致密材料之间的阻抗不匹配,超声波在高声阻抗波导(称为致密材料)中的传输效率很低,这对超声治疗或医学成像等高强度聚焦超声(HIFU)的实际应用构成了重大障碍。为了应对这一挑战,我们提出了一种用于制造新型声学元透镜的反向优化方案,当超声波穿越障碍物时,这种透镜能够加强超声波的穿透力和聚焦能力。模拟和实验都验证了所开发的元透镜的有效性,与不使用元透镜的情况相比,元透镜附着在半球形板上,可将声功率的传输提高一个数量级。通过调整元透镜的几何参数,可以重新配置焦距。所提出的设计理念不受目标结构复杂性的限制,允许超声波穿过厚度不均匀的声屏障,同时保持高效的波聚焦。这项研究在支持 HIFU 的超声成像和治疗方面有着极具吸引力的应用。
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引用次数: 0
Insight into wave propagation in polyimide films and resistive grid sandwich structures towards a hybrid monitoring of hypervelocity impact 洞察波在聚酰亚胺薄膜和电阻网格夹层结构中的传播,实现超高速撞击的混合监测
IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2024-09-16 DOI: 10.1016/j.ultras.2024.107471
Shun Lu , Pinliang Zhang , Qian Yu , Qiang Wu , Zizheng Gong , Menglong Liu

Micro-Meteoroid and Orbital Debris pose a significant threat to the safe operation of orbiting spacecraft, potentially leading to mission failure in space exploration. Quantitative characterization of hypervelocity impact (HVI) is crucial to ensure the safety and successful completion of on-orbit missions. Firstly, this study designed a three-layer sandwich structure of polyimide film with orthogonally laid resistive wires, combined with piezoelectric and resistive wire sensors, for the simultaneous acquisition of acoustic emission (AE) signals generated by HVI and measurement of perforation dimensions. Secondly, a semi-analytical finite element (SAFE) analysis of wave dispersion properties in the periodic sandwich structure is conducted with Bloch’s theorem, together with a hybrid model based on three-dimensional smoothed particle hydrodynamics and finite element methods (SPH-FEM) to comprehensively understand the AE waves and damage characteristics induced by HVI. The resulting anisotropic wave propagation characteristics with SAFE and SPH-FEM are closely matched. Thirdly, a time delay-multiplication (TDM) imaging algorithm considering wave velocity anisotropy is proposed for accurate real-time “visualization” of HVI locations. Lastly, correlations are established between projectile and perforation dimensions. The proposed algorithm for HVI multi-parameter quantification and damage detection helps evaluate the space HVI environment and HVI-induced damage to spacecraft.

微流星体和轨道碎片对轨道航天器的安全运行构成重大威胁,可能导致空间探索任务失败。超高速撞击(HVI)的定量表征对于确保在轨飞行任务的安全和顺利完成至关重要。首先,本研究设计了一种由聚酰亚胺薄膜和正交铺设的电阻丝组成的三层夹层结构,并结合压电和电阻丝传感器,用于同时采集 HVI 产生的声发射(AE)信号和测量穿孔尺寸。其次,利用布洛赫定理以及基于三维平滑粒子流体力学和有限元方法(SPH-FEM)的混合模型,对周期性夹层结构中的波扩散特性进行了半解析有限元(SAFE)分析,以全面了解 HVI 诱导的 AE 波和损伤特征。通过 SAFE 和 SPH-FEM 得出的各向异性波传播特性非常吻合。第三,提出了一种考虑波速各向异性的延时-乘法(TDM)成像算法,以准确实时地 "可视化 "高频干扰源位置。最后,建立了射弹和射孔尺寸之间的相关性。所提出的高频干扰多参数量化和损伤检测算法有助于评估空间高频干扰环境和高频干扰对航天器造成的损伤。
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引用次数: 0
Research on ultrasonic-assisted vibration multi-cycle compaction method of flexible guided 3D weaving 柔性导向三维编织的超声波辅助振动多循环压实法研究。
IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2024-09-14 DOI: 10.1016/j.ultras.2024.107461
Wudi Du , Zhongde Shan , Feng Liu , Xiaochuan Wu , Zhe Chen , Guisheng Zou
The structure of three-dimensional (3D) preforms is the key to the performance of 3D reinforced composites. In order to improve the quality and efficiency of manufacturing, this paper originally proposes the ultrasonic vibration-assisted multi-cycle compaction method. Ultrasonic vibrations are applied, using a resonant 40 kHz compactor, to the compaction of 3D carbon fiber preform. Compared to the traditional method, the ultrasonic vibration-assisted multi-cycle compaction method can accelerate stress relaxation and reduce preform springback. The microstructure of preform is observed using x-ray computer tomography imaging. It elucidates the mechanism by which ultrasonic vibration promotes fiber slippage. The compaction forming experiment of preforms has proven that the ultrasonic vibration-assisted multi-cycle compaction method can reduce the compaction time, improving the forming quality. This can improve the technical support for the improvement of the manufacturing level of the 3D preform.
三维(3D)预制件的结构是三维增强复合材料性能的关键。为了提高制造质量和效率,本文最初提出了超声波振动辅助多循环压实法。利用共振频率为 40 kHz 的压实机对三维碳纤维预型件进行超声波振动压实。与传统方法相比,超声波振动辅助多循环压实法能加速应力松弛,减少预成型回弹。利用 X 射线计算机断层扫描成像技术观察了预成型件的微观结构。它阐明了超声振动促进纤维滑移的机理。预型件的压实成型实验证明,超声波振动辅助多循环压实法可以缩短压实时间,提高成型质量。这为提高三维预制棒的制造水平提供了技术支持。
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引用次数: 0
Microbubble tracking based on partial smoothing-based adaptive generalized labelled Multi-Bernoulli filter for super-resolution imaging 基于部分平滑的自适应广义标记多伯努利滤波器的微气泡跟踪技术,用于超分辨率成像
IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2024-09-14 DOI: 10.1016/j.ultras.2024.107455
Jiacheng Liu , Meiling Liang , Jinxuan Ma , Liyuan Jiang , Hanbing Chu , Chao Guo , Jianjun Yu , Yujin Zong , Mingxi Wan
Super-resolution ultrasound (SRUS) can image the vasculature at microscopic resolution according to microbubble (MB) localization, with velocity vector maps obtained based on MB tracking information. High MB concentrations can reduce the acquisition time of SRUS imaging, however adjacent and intersecting vessels are difficult to distinguish, thus decreasing resolution. Low acquisition frame rates affect the precision of flow velocity estimation. This study proposes a partial smoothing-based adaptive generalized labeled multi-Bernoulli filter (SAGLMB) to precisely track the MB motion at different flow velocities. SAGLMB employs a generalized labelled multi-Bernoulli filter (GLMB) for MB trajectory allocation to separate adjacent and intersecting vessels. Furthermore, the nonlinear motion of MB was predicted by an unscented Kalman filter, and a cardinalized probability hypothesis density filter was applied to suppress clutter interference. Finally, the trajectories were smoothed by unscented Rauch-Tung-Striebel to improve the resolution of the SRUS image. The simulation results demonstrate that SAGLMB outperforms the conventional bipartite graph-based tracking at high MB concentrations, achieving at least an 8.55 % improvement in the correctly paired precision, with 3 times increase in the structural similarity index measure. Moreover, SAGLMB can obtain more precise flow velocity estimations with a 4 times improvement than the conventional method. The SRUS results of rabbit kidney show that the proposed method significantly improves resolution of adjacent and intersecting vessels at higher MB concentrations and maintains this performance as the acquisition frame rate decreases. Furthermore, the rat brain microvascular network was reconstructed with 9.21 μm (λ/11.1) resolution. Therefore, SAGLMB can achieve robust SRUS imaging at high concentrations and low acquisition frame rates.
超分辨率超声(SRUS)可根据微泡(MB)定位以微观分辨率对血管成像,并根据 MB 跟踪信息获得速度矢量图。高浓度的微泡可缩短 SRUS 成像的采集时间,但相邻和相交的血管难以区分,从而降低了分辨率。采集帧率低会影响流速估算的精度。本研究提出了一种基于部分平滑的自适应广义标记多贝努利滤波器(SAGLMB),以精确跟踪不同流速下的 MB 运动。SAGLMB 采用广义标记多贝努利滤波器(GLMB)进行 MB 轨迹分配,以分离相邻和相交的血管。此外,甲基溴的非线性运动是通过无香味卡尔曼滤波器预测的,并且应用了一个红心概率假设密度滤波器来抑制杂波干扰。最后,利用非特征 Rauch-Tung-Striebel 对轨迹进行平滑处理,以提高 SRUS 图像的分辨率。仿真结果表明,在 MB 浓度较高的情况下,SAGLMB 优于传统的基于双方形图的跟踪方法,其正确配对精度至少提高了 8.55%,结构相似性指数提高了 3 倍。此外,SAGLMB 还能获得更精确的流速估计,比传统方法提高了 4 倍。兔肾脏的 SRUS 结果表明,在 MB 浓度较高的情况下,所提出的方法能显著提高相邻和相交血管的分辨率,并能在采集帧速率降低时保持这种性能。此外,大鼠脑部微血管网络的重建分辨率为 9.21 μm(λ/11.1)。因此,SAGLMB 可以在高浓度和低采集帧频条件下实现稳健的 SRUS 成像。
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引用次数: 0
Steerable ultrasonic propulsion of rigid objects based on circular pressure modulation of a focused sectorial transducer array 基于聚焦扇形换能器阵列的环形压力调制的刚性物体可转向超声波推进器
IF 3.8 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2024-09-14 DOI: 10.1016/j.ultras.2024.107475
Wenyi Li , Tingzhen Feng , Tinghui Meng , Gepu Guo , Juan Tu , Dong Zhang , Qingyu Ma

As a common disease of human urinary system, the high prevalence and incidence rate of renal calculus have brought heavy burden to society. Traditional ultrasonic lithotripsy struggles with the comprehensive elimination of residual fragments and may inadvertently inflict renal damage. Although focused ultrasound can propel stones by the acoustic radiation force (ARF) with minimal tissue damage and enhanced passage rate, it is still lack of the accurate control for calculi at different locations. A circular pressure modulation approach for steerable ultrasonic propulsion of rigid objects is developed based on a sector-array of focused transducers. The ARF exerted on on-axis rigid spheres (stones) is derived based on acoustic scattering. It is proved that the ARF of focused fields exhibits an axial distribution of increasing followed by decreasing with the peak slightly beyond the focus. As the sphere radius increases, the ARF exerted on spheres at the focus increases accordingly with a decreasing growth rate. Inclined propulsion can be realized by the circular binary pressure modulation with the deflection increased by expanding the angle of power-off sector sources. The maximum deflection angle approaching 60° is determined by the F-number and element number of the sector-array. Experimental propulsions of steel balls are conducted using an 8-element sector-array with motion trajectories captured by a high-speed camera. Distributions of the motion speed and acceleration for steel balls of different radii are calculated through image processing. The ARF of mN level and the deflection angle of 12° are demonstrated by the successful propulsion of steel balls. This research provides an effective and flexible approach of steerable stone propulsion using an ultrasonic power supply without the complex control in amplitude or phase and the high-precision motion of the sector-array, hence promoting the practical application in non-invasive treatment of stones.

作为人类泌尿系统的常见疾病,肾结石的高患病率和发病率给社会带来了沉重的负担。传统的超声波碎石难以全面清除残留碎石,并可能在不经意间对肾脏造成损伤。虽然聚焦超声能通过声辐射力(ARF)推动结石,对组织损伤小,通过率高,但仍缺乏对不同位置结石的精确控制。基于聚焦换能器的扇形阵列,我们开发了一种用于刚性物体可转向超声波推进的环形压力调制方法。根据声散射推导出施加在轴向刚性球体(石头)上的 ARF。研究证明,聚焦场的 ARF 呈先增后减的轴向分布,峰值略高于焦点。随着球体半径的增加,焦点处施加在球体上的 ARF 也会相应增加,但增长率会降低。倾斜推进可以通过圆形二元压力调制来实现,通过扩大断电扇形源的角度来增加偏转。接近 60° 的最大偏转角由扇形阵列的 F 数和元素数决定。使用 8 元扇形阵列进行了钢球推进实验,高速摄像机捕捉了运动轨迹。通过图像处理计算了不同半径钢球的运动速度和加速度分布。通过成功推进钢球,证明了 mN 级的 ARF 和 12° 的偏转角。这项研究提供了一种有效而灵活的方法,即利用超声波电源进行可转向的结石推进,而无需复杂的振幅或相位控制以及扇形阵列的高精度运动,从而促进了结石无创治疗的实际应用。
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