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Histotripsy-mediated reactive oxygen species generation in vitro 组织三聚体介导的体外活性氧生成
IF 4.1 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2025-11-09 DOI: 10.1016/j.ultras.2025.107885
Gregory J. Anthony , Steffen Sammet, Jeffrey S. Souris, Kenneth B. Bader
Forms of sonodynamic therapy rely on close interactions between microbubbles and agents to generate cytotoxic reactive oxygen species. Microbubbles are inherently intravascular agents, which limits the therapeutic range for effective distribution of reactive oxygen species. Histotripsy is a focused ultrasound therapy that ablates tissue via the generation of a dense cloud of bubbles spontaneously without the need for microbubbles. This study investigated the capacity of histotripsy to generate the hydroxyl radical with and without sonodynamic agents. In the absence of sonodynamic agents, histotripsy produced the hydroxyl radical at rate that was increased by a factor of three relative to other forms of therapeutic ultrasound. These sonochemical reactions were found to correlate strongly with acoustic emissions tracked with passive cavitation imaging. Histotripsy bubble activity was found to increase the rate of hydroxyl radical production for multiple sonosensitizers relative to controls, particularly for ultrasound pulses longer than 20 cycles (i.e., 20 μs) in duration. Overall, these data indicate histotripsy may be a viable approach for activating sonosensitve agents, and this activation may be tracked based on acoustic emission.
声动力疗法的形式依赖于微泡和药物之间的密切相互作用来产生细胞毒性活性氧。微泡本质上是血管内的药物,这限制了活性氧有效分布的治疗范围。组织切片术是一种聚焦超声疗法,通过自发产生密集的气泡云来消融组织,而不需要微气泡。本研究考察了在有和没有声动力剂的情况下组织切片产生羟基自由基的能力。在没有声动力剂的情况下,组织切片术产生羟基自由基的速度比其他形式的治疗超声增加了三倍。这些声化学反应被发现与被动空化成像跟踪的声发射密切相关。研究发现,相对于对照组,组织学泡活性增加了多种超声增敏剂羟基自由基的产生率,特别是对于持续时间超过20个周期(即20 μs)的超声脉冲。总的来说,这些数据表明,组构法可能是激活声敏感剂的一种可行方法,并且这种激活可以基于声发射进行跟踪。
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引用次数: 0
A multi-mode coupling damage classification method for composite structures based on acoustic emission signal decomposition 基于声发射信号分解的复合材料结构多模耦合损伤分类方法
IF 4.1 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2025-11-09 DOI: 10.1016/j.ultras.2025.107886
Yinmin Zhu , Wenhao Li , Jing Lin , Fei Gao , Zongyang Liu
Multi-mode damage coupling in composite structures is a key factor preventing accurate classification of different damage types. To address this, this paper presents a damage classification framework for composite structures based on acoustic emission (AE) signal decomposition. The approach begins by generating a Peak Frequency-Normalized Count Spectrum using Pearson correlation, principal component analysis, and hierarchical clustering. This spectrum, combined with electron microscopy observations, allows for quick identification of damage types and their frequency ranges, even with limited understanding of damage mechanisms. A customized wavelet packet decomposition filter is then created to decompose AE signals, enabling precise classification of different damage types. To validate the method, multiple tensile tests on adhesive composite joints were conducted, and the AE data were classified using both the proposed method and the K-means method. The results show that, compared to the K-means method, the energy proportions of the three types of damage classified by our method consistently remain in the range of 30%-40%, with the normalized energy proportion of adhesive debonding reaching or even exceeding 50%. Our method more accurately reflects the true damage state of the specimens. It effectively mitigates the negative impact caused by the coupling of multiple damage modes, providing a new perspective for health monitoring of composite structures.
复合材料结构的多模态损伤耦合是影响损伤类型准确分类的关键因素。针对这一问题,提出了一种基于声发射信号分解的复合材料结构损伤分类框架。该方法首先使用Pearson相关性、主成分分析和分层聚类生成峰值频率归一化计数谱。该光谱与电子显微镜观察相结合,即使对损伤机制的了解有限,也可以快速识别损伤类型及其频率范围。然后创建定制的小波包分解滤波器来分解声发射信号,从而实现不同损伤类型的精确分类。为了验证该方法,对粘接复合材料接头进行了多次拉伸试验,并使用该方法和K-means方法对声发射数据进行了分类。结果表明,与K-means方法相比,我们的方法分类的三种损伤类型的能量占比始终保持在30%-40%的范围内,其中胶粘剂脱粘的归一化能量占比达到甚至超过50%。该方法更准确地反映了试件的真实损伤状态。它有效地减轻了多种损伤模式耦合带来的负面影响,为复合材料结构的健康监测提供了新的视角。
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引用次数: 0
A pulse-echo sound speed estimation approach with prior constraints for layered media 层状介质中具有先验约束的脉冲回波声速估计方法
IF 4.1 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2025-11-07 DOI: 10.1016/j.ultras.2025.107871
Nuomin Zhang , Yang Xiao , Yiyin Su , Xuanhao Wang , Xudong Yang , Junhui Shi
This paper presents a pulse-echo sound speed estimation method for layered media, utilizing prior-constrained coherent analysis. The proposed method addresses the instability in local sound speed estimation caused by phase ambiguities resulting from suboptimal probe configurations. By introducing biologically reasonable sound speed boundary constraints to compensate for errors in average sound speed (ASS) estimation, and integrating sparse interface regularization inversion models, this method suppresses noise amplification during inversion, thereby enhancing robustness. The experimental results demonstrate that using this method significantly improves performance in simulations and in vitro data, reducing the root-mean-square error (RMSE) by 68% compared to existing methods. In in vivo experiments, the average sound speed in the tested regions deviated less than 0.6% from the reference values, while maintaining high repeatability. Furthermore, ablation studies validate the synergistic effect of prior compensation and sparse regularization, confirming their effectiveness in reducing phase sensitivity and enhancing the resolution of stratified structures. This method provides a reliable quantitative sound speed assessment tool for clinical scenarios such as hepatic steatosis, simultaneously relaxing hardware requirements for ultrasound probe parameters.
本文提出了一种基于先验约束相干分析的层状介质脉冲回波声速估计方法。该方法解决了由次优探头配置引起的相位模糊引起的局部声速估计不稳定问题。该方法通过引入生物合理的声速边界约束来补偿平均声速(ASS)估计中的误差,并集成稀疏界面正则化反演模型,抑制了反演过程中的噪声放大,从而增强了鲁棒性。实验结果表明,与现有方法相比,该方法显著提高了模拟和体外数据的性能,将均方根误差(RMSE)降低了68%。在体内实验中,被测区域的平均声速与参考值的偏差小于0.6%,同时保持了较高的重复性。此外,烧蚀研究验证了先验补偿和稀疏正则化的协同效应,证实了它们在降低相位灵敏度和提高分层结构分辨率方面的有效性。该方法为肝脂肪变性等临床情况提供了可靠的定量声速评估工具,同时降低了超声探头参数的硬件要求。
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引用次数: 0
Predicting hydrophone phase and evaluating its uncertainty using magnitude data and minimum phase approach 利用震级数据和最小相位法预测水听器相位并评估其不确定性。
IF 4.1 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2025-11-06 DOI: 10.1016/j.ultras.2025.107884
Hasan Koruk , Srinath Rajagopal , William Vale , Andrew M. Hurrell
Hydrophones are commonly used to measure the acoustic output of ultrasound transducers and devices. Commonly, only the magnitude response of a hydrophone is quantified, since the direct measurement of phase response requires a complicated calibration procedure, and phase is extremely sensitive to small variations in experimental conditions such as alignment of hydrophone in the ultrasound field, signal-to-noise ratio, and temperature of water. However, for linear, time-invariant systems, phase can be predicted from the magnitude spectrum using the minimum phase approach. Here, a procedure was established to estimate the phase and evaluate the phase uncertainty of a hydrophone. The phase response was calculated using the minimum phase approach and the preconditioned magnitude spectrum. By using the uncertainty in the magnitude spectrum and the propagation of uncertainty, the uncertainty in the subsequently derived phase was calculated. A machine learning model was used to determine the phase uncertainty arising from applying the minimum phase approach to band-limited magnitude spectrum. After the performances of the calculation methods for phase and phase uncertainty were evaluated, the proposed procedure was implemented and assessed using a hydrophone model and two hydrophones with characterised magnitude and phase responses with their associated uncertainties. The predicted phase responses and evaluated uncertainties were comparable to the reference values. The results indicated that the procedure presented in this study could be used in practice to predict the phases and evaluate the phase uncertainties of various hydrophones.
水听器通常用于测量超声波换能器和设备的声输出。通常,只有水听器的幅度响应被量化,因为相位响应的直接测量需要一个复杂的校准过程,并且相位对实验条件的微小变化非常敏感,例如水听器在超声场中的对准,信噪比和水的温度。然而,对于线性时不变系统,相位可以使用最小相位法从幅度谱中预测。本文建立了水听器相位估计和相位不确定度的计算方法。采用最小相位法和预置幅度谱计算了相位响应。利用幅度谱的不确定度和不确定度的传播特性,计算了后续导出相位的不确定度。使用机器学习模型来确定将最小相位方法应用于带限幅度谱所产生的相位不确定性。在对相位和相位不确定性计算方法的性能进行评估之后,使用一个水听器模型和两个具有特征幅度和相位响应及其相关不确定性的水听器对所提出的程序进行了实施和评估。预测的相响应和评估的不确定度与参考值相当。结果表明,该方法可用于各种水听器的相预测和相不确定度评定。
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引用次数: 0
Bidirectional excitation and detection of Rayleigh waves via two facing elliptical reflectors 两面椭圆反射器双向激发和瑞利波探测。
IF 4.1 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2025-11-03 DOI: 10.1016/j.ultras.2025.107883
Kyohei Yamada , Shoki Ieiri , Shinsuke Itoh , Takashi Kasashima , Chikahiro Imashiro , Takeshi Morita
This study describes the bidirectional excitation and detection of Rayleigh waves using two facing elliptical reflector focusing structures (ELIPS), in contrast to previous studies that have achieved only one-way excitation and did not demonstrate detection. First, the design of a proposed ELIPS surface-acoustic-wave (SAW) device is presented, and the relationship between the design parameters and SAW excitation performance is clarified. Next, finite element method simulations are presented, showing that 40 % of the energy of the incident dilatational wave is converted into a SAW and 60 % of the generated SAW is reconverted into a received dilatational wave. Finally, bidirectional SAW excitation and detection are demonstrated. In the experiment, a 5-cycle, 1  MHz burst signal with an amplitude of 10 Vpp was used to excite Rayleigh waves in both the forward and reverse directions. In the forward direction, a SAW vibration velocity of 5.4  mm/s was obtained and the received voltage reached 21 % of the applied voltage. In the reverse direction, the vibration velocity was 5.8  mm/s and the received voltage reached 22 %. These received voltage ratios are sufficient for sensing applications. Moreover, the response remained linear up to at least 140 Vpp, producing vibration amplitudes of 13 and 12 nm, adequate for high-power applications and with potential for further increase at higher input power.
本研究描述了使用两个面向椭圆反射聚焦结构(ELIPS)的瑞利波的双向激发和检测,与以往的研究相比,这些研究只实现了单向激发并且没有演示检测。首先,提出了一种拟建的ELIPS声表面波(SAW)装置的设计,并阐明了设计参数与声表面波激励性能之间的关系。有限元模拟结果表明,入射膨胀波能量的40%转化为声波,产生的声波能量的60%再转化为接收的膨胀波。最后演示了双向声表面波的激励和检测。实验采用5周期、1 MHz、振幅为10 Vpp的突发信号分别激励正向和反向瑞利波。在正向方向上,SAW的振动速度为5.4 mm/s,接收电压达到施加电压的21%。相反方向,振动速度为5.8 mm/s,接收电压达到22%。这些接收电压比足以用于传感应用。此外,在至少140 Vpp的情况下,响应保持线性,产生13和12 nm的振动幅值,足以用于高功率应用,并且在更高的输入功率下有进一步增加的潜力。
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引用次数: 0
End-to-end design of multi-functional acoustic holograms via heterogeneous physics constraints 基于异构物理约束的多功能声全息图端到端设计。
IF 4.1 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2025-11-01 DOI: 10.1016/j.ultras.2025.107879
Chuanxin Zhang , Xue Jiang , Dean Ta
Acoustic holograms offer precise three-dimensional control of sound fields with immense potential for non-invasive therapies and contactless manipulation. However, conventional phase-only design methods suffer from a fundamental performance gap between theoretical predictions and physical implementation, especially for creating multi-functional devices. These approaches design idealized phase maps while neglecting complex wave physics within hologram structures and distorting effects of heterogeneous biological tissues. Here, we introduce the End-to-End Heterogeneous Physics-Constrained (E2E-HPC) framework, a deep learning paradigm that resolves this gap by directly designing the physical hologram structure. Our framework is guided by integrated, differentiable models that account for both the hologram’s intricate internal acoustics and wave propagation through complex media like the skull. This heterogeneous physics-constrained approach eliminates the performance limitations of conventional methods, improving the resulting acoustic pattern’s fidelity by over 6 dB in Peak Signal-to-Noise Ratio (PSNR) and recovering ∼16 % of the correlation fidelity lost in physical implementation. Beyond single-target design, we demonstrate the framework’s extensibility for multi-functional controls by creating a single hologram capable of both simultaneous, high-fidelity focusing on multiple axial planes and dynamic pattern switching by modulating the input frequency. As a proof-of-concept for therapeutic applications, we showcase real-time, frequency-specific switching of thermal patterns. These results establish a robust platform for designing physically realizable, multi-functional acoustic holograms for challenging biomedical applications.
声全息图提供精确的声场三维控制,具有非侵入性治疗和非接触式操作的巨大潜力。然而,传统的纯相位设计方法在理论预测和物理实现之间存在根本的性能差距,特别是在创建多功能器件时。这些方法设计了理想的相位图,而忽略了全息图结构中的复杂波物理和异质生物组织的扭曲效应。在这里,我们介绍了端到端异构物理约束(E2E-HPC)框架,这是一种深度学习范式,通过直接设计物理全息图结构来解决这一差距。我们的框架由集成的、可微分的模型指导,这些模型既考虑了全息图复杂的内部声学,也考虑了波在头骨等复杂介质中的传播。这种异构物理约束的方法消除了传统方法的性能限制,在峰值信噪比(PSNR)中提高了6 dB以上的声学模式保真度,并恢复了物理实现中丢失的相关保真度的约16%。除了单目标设计之外,我们还通过创建一个能够同时高保真地聚焦于多个轴面和通过调制输入频率进行动态模式切换的单一全息图来展示该框架的多功能控制的可扩展性。作为治疗应用的概念验证,我们展示了实时,特定频率的热模式切换。这些结果为设计具有挑战性的生物医学应用的物理可实现的多功能声全息图建立了一个强大的平台。
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引用次数: 0
Wave propagation in highly anisotropic polycrystals: a numerical perspective from an unstructured-mesh-based high-order finite element method 波在高度各向异性多晶体中的传播:基于非结构网格的高阶有限元方法的数值视角。
IF 4.1 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2025-10-31 DOI: 10.1016/j.ultras.2025.107882
Shaojie Gong , Shifeng Guo , Yi Xiong , Shiyuan Zhou , Fangsen Cui , Menglong Liu
Ultrasonic non-destructive testing provides an important means to characterize grain size and orientation distribution of polycrystalline materials. Analytical and numerical modeling of ultrasound propagation offer an insight into how ultrasound interacts with polycrystalline materials. However, in highly anisotropic polycrystals, there is still no mature and accurate analytical formulation to describe the strong wave scattering, while the numerical modeling often relies on extremely dense structured meshes to conform to the grain boundary. This study proposes to use a high-order unstructured mesh with added internal nodes to obtain diagonal mass matrices, in order to accurately model wave propagation in strongly anisotropic polycrystals with complex grain boundary. Firstly, polycrystalline geometry was constructed with the Voronoi-based tessellation. Then an explicit dynamics solution was to simulate ultrasonic propagation with the improved element and several typical structured and unstructured elements. The influence of mesh type on calculation accuracy and convergence rate shows that the improved high-order mass-lumped elements, by retaining the true geometry of grain boundaries with unstructured meshes, significantly enhance both computational efficiency and accuracy. Lastly, the simulated results of ultrasonic attenuation and phase velocity in polycrystals show good agreement with both modified analytical models and results obtained with structured meshes. This confirms the effectiveness of the proposed high-order mass-lumped unstructured meshes for accurately simulating wave propagation in polycrystals for the characterization of grain features.
超声无损检测是表征多晶材料晶粒尺寸和取向分布的重要手段。超声传播的分析和数值模拟提供了超声如何与多晶材料相互作用的见解。然而,在高度各向异性的多晶体中,仍然没有成熟而准确的解析公式来描述强波散射,而数值模拟往往依赖于极其密集的结构网格来符合晶界。为了精确模拟复杂晶界强各向异性多晶体中的波传播,本研究提出采用高阶非结构化网格增加内部节点来获得对角质量矩阵。首先,利用基于voronoi的镶嵌构造了多晶几何结构。然后用改进单元和几种典型的结构化和非结构化单元对超声传播进行了显式动力学模拟。网格类型对计算精度和收敛速度的影响表明,改进的高阶质量集总单元通过保留非结构化网格的真实晶界几何形状,显著提高了计算效率和精度。最后,超声衰减和相速度在多晶体中的模拟结果与修正的解析模型和结构网格计算结果吻合较好。这证实了所提出的高阶质量集总非结构化网格在精确模拟波在多晶体中的传播以表征晶粒特征方面的有效性。
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引用次数: 0
A miniature wireless robotic swimmer actuated by a vector acoustic system 由矢量声学系统驱动的微型无线游泳机器人
IF 4.1 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2025-10-28 DOI: 10.1016/j.ultras.2025.107880
Xin Wang , Le Wang , Hanlin Wang , Xiqing Zuo , Rongyang Wang , Xianglei Zhang , Chao Xu
Untethered underwater robots are capable of navigating confined aquatic environments, offering significant potential for applications such as environmental monitoring, pipeline inspection and biological sample collection. However, traditional propeller propulsion systems suffer from limited maneuverability and potential safety risks in confined spaces. To address these challenges, we propose a miniature robotic swimmer (8.5 cm in diameter and 10 cm in height) actuated by a vector acoustic system. Specifically, the robot employs a piezoelectric transducer to generate high-intensity ultrasonic waves, which produce a directional jet in the fluid by acoustic radiation force. By using a miniature electromagnetic motor to adjust the alignment of the piezoelectric actuator, the system can modify the jet direction, achieving full-range propulsion without turning radius limitations. Moreover, the combined implementation of a vectorized propulsion system with a wireless control module enables superior maneuverability. Experiments show that the robot achieves a maximum linear velocity of 79.2 mm/s and can traverse a narrow gap of 1.5 times the body length under remote wireless control, demonstrating excellent maneuverability and obstacle avoidance capability.
无系绳水下机器人能够在狭窄的水生环境中航行,为环境监测、管道检查和生物样本收集等应用提供了巨大的潜力。然而,传统的螺旋桨推进系统在密闭空间中存在机动性有限和安全隐患的问题。为了解决这些挑战,我们提出了一个由矢量声学系统驱动的微型机器人游泳者(直径8.5厘米,高10厘米)。具体而言,该机器人采用压电换能器产生高强度超声波,通过声辐射力在流体中产生定向射流。该系统利用微型电磁电机调节压电驱动器的对中方向,实现无转弯半径限制的全范围推进。此外,矢量推进系统与无线控制模块的结合实现了优越的机动性。实验结果表明,在远程无线控制下,机器人的最大线速度可达79.2 mm/s,并能通过1.5倍体长的狭窄缝隙,具有良好的机动性和避障能力。
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引用次数: 0
Improving axial resolution uniformity in deep-tissue optoacoustic imaging via entropy-driven design of dual-frequency multi-segment arrays 利用熵驱动双频多段阵列改善深层组织光声成像的轴向分辨率均匀性。
IF 4.1 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2025-10-28 DOI: 10.1016/j.ultras.2025.107875
Weixia Cheng , Ruochong Zhang , Cristian Ciobanu , Renzhe Bi , Xosé Luís Deán-Ben , Zheng Zesheng , Ghayathri Balasundaram , Yonggeng Goh , Malini Olivo , Daniel Razansky , Zheng Fan
Dual-frequency or multi-frequency transducers have been proposed to balance deep penetration and high resolution in optoacoustic (OA) imaging, based on the well-established tradeoff that low frequencies provide deeper penetration, while high frequencies offer higher resolution. In practice, conventional transducer designs are primarily guided by the signal’s center frequency and bandwidth, as these parameters fundamentally constrain spatial resolution. However, such criteria alone are insufficient, as they overlook the influence of transducer geometry within the array. To address this limitation, we introduce k-space analysis and a weighted entropy (WE) metric that links transducer design parameters to directional resolution performance. Simulations and phantom experiments validated that the dual-frequency multi-segment transducer array (DF-MSTA), combining 3 and 7.5 MHz, achieved more uniform and enhanced axial resolution (by up to 23.8 %), compared to a single-frequency MSTA operating at 7.5 MHz. The results align with predictions from the k-space analysis and WE quantification. This work provides a transducer design strategy that jointly considers frequency selection and array geometry, along with a quantitative framework to optimize axial resolution in deep-tissue OA imaging, offering insights beyond conventional approaches.
基于低频提供更深的穿透,而高频提供更高的分辨率这一公认的权衡,双频或多频换能器已被提议用于平衡光声(OA)成像中的深穿透和高分辨率。在实践中,传统的换能器设计主要以信号的中心频率和带宽为指导,因为这些参数从根本上限制了空间分辨率。然而,这样的标准本身是不够的,因为它们忽略了阵列内换能器几何形状的影响。为了解决这一限制,我们引入了k空间分析和加权熵(we)度量,将传感器设计参数与方向分辨率性能联系起来。仿真和模拟实验证实,与7.5 MHz的单频MSTA相比,结合3和7.5 MHz的双频多段换能器阵列(DF-MSTA)实现了更均匀和增强的轴向分辨率(高达23.8%)。结果与k空间分析和WE量化的预测一致。这项工作提供了一种换能器设计策略,该策略联合考虑了频率选择和阵列几何形状,以及优化深层组织OA成像轴向分辨率的定量框架,提供了超越传统方法的见解。
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引用次数: 0
Golay-Net: Deep learning-based Golay coded excitation for ultrasound imaging Golay- net:基于深度学习的超声成像Golay编码激励
IF 4.1 2区 物理与天体物理 Q1 ACOUSTICS Pub Date : 2025-10-28 DOI: 10.1016/j.ultras.2025.107881
Suntae Hwang , Jinwoo Kim , Eunji Lee , Jin Ho Chang
Ultrasound imaging modality, which operates by transmitting and receiving short ultrasound pulses, offers a promising approach for real-time, high-resolution diagnostic imaging at relatively low cost. However, the conventional short-pulse approach is inherently limited by signal attenuation with increased imaging depth, leading to reduced penetration and a lower signal-to-noise ratio (SNR), which ultimately degrades diagnostic performance. Golay-coded excitation has been introduced to mitigate these issues by transmitting longer, coded pulses that use a pair of complementary sequences (Codes A and B) to enhance SNR and imaging depth. However, this technique requires two sequential transmissions to acquire two echoes related to the complementary codes, inevitably reducing the frame rate by half. In this work, we propose a novel deep learning framework that overcomes this limitation by generating the echo signal corresponding to Code B from the echo signal obtained after transmitting code A. For this, we developed Golay-Net, based on a 1-D U-Net architecture, which changes the phase of the range sidelobes of the Code A-related echo signals, thereby effectively synthesizing the echo signals that would have been obtained using Code B. In vitro and in vivo experiments demonstrate that the proposed Golay-Net can synthesize code B-related echo signals with high fidelity, enabling the reconstruction of ultrasound images with enhanced SNR and imaging depth, without compromising frame rate.
超声成像模式通过发送和接收短超声脉冲来工作,以相对较低的成本提供了一种有前途的实时、高分辨率诊断成像方法。然而,随着成像深度的增加,传统的短脉冲方法固有地受到信号衰减的限制,从而导致穿透降低和信噪比(SNR)降低,最终降低了诊断性能。为了缓解这些问题,已经引入了golay编码激励,通过使用一对互补序列(编码a和B)传输更长的编码脉冲来提高信噪比和成像深度。然而,这种技术需要两次连续传输来获取与互补码相关的两个回波,不可避免地将帧率降低一半。在这项工作中,我们提出了一种新的深度学习框架,通过从发送代码a后获得的回波信号中生成与代码B对应的回波信号来克服这一限制。为此,我们开发了基于一维U-Net架构的Golay-Net,该架构改变了代码a相关回波信号的距离旁瓣的相位。体外和体内实验表明,所提出的Golay-Net可以高保真地合成与b码相关的回波信号,在不影响帧率的情况下,重建具有更高信噪比和成像深度的超声图像。
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