Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9521
Shikha Pandeyv
Cervical Spondylosis is a common cause of chronic Neck pain. The term spondylosis refers to degenerative osteoarthritis of the joints between the cervical vertebrae. When the space between the two adjacent vertebrae narrows, the compression of a nerve root emerging from the spinal cord may result in sensory and motor disturbance such as severe pain in the neck, back, shoulder, legs and arms depends on the area where it is affected. The patients may experience shock in the hands or legs. The nerve compression leads to decrease in blood circulation in the affected area. Due to the faulty life style of people this has become a major cause of hampering peace.so the present study has been done focusing on this emerging issue. In which Mashbaladi Pachan Kashaya Nasya was selected for the present study to see its effect on Cervical Spondylosis. 15 patients selected from the Panchkarma and Kaya-Chikitsa O.P.D. & were treated with Maashbaladi Pachan Kashaya Nasya. Assessment was done on the basis of chief complain & associated complain by applying appropriate statistical test. the intervention was found to be highly significant (p<0.001) in reducing pain, stiffness, and in ristricted movement of neck as well as associated symptoms.
{"title":"CLINICAL STUDY TO EVALUATE THE EFFECT OF MASHBALADI PACHANA KASHAYA NASYA IN CERVICAL SPONDYLOSIS","authors":"Shikha Pandeyv","doi":"10.20959/wjpr201711-9521","DOIUrl":"https://doi.org/10.20959/wjpr201711-9521","url":null,"abstract":"Cervical Spondylosis is a common cause of chronic Neck pain. The term spondylosis refers to degenerative osteoarthritis of the joints between the cervical vertebrae. When the space between the two adjacent vertebrae narrows, the compression of a nerve root emerging from the spinal cord may result in sensory and motor disturbance such as severe pain in the neck, back, shoulder, legs and arms depends on the area where it is affected. The patients may experience shock in the hands or legs. The nerve compression leads to decrease in blood circulation in the affected area. Due to the faulty life style of people this has become a major cause of hampering peace.so the present study has been done focusing on this emerging issue. In which Mashbaladi Pachan Kashaya Nasya was selected for the present study to see its effect on Cervical Spondylosis. 15 patients selected from the Panchkarma and Kaya-Chikitsa O.P.D. & were treated with Maashbaladi Pachan Kashaya Nasya. Assessment was done on the basis of chief complain & associated complain by applying appropriate statistical test. the intervention was found to be highly significant (p<0.001) in reducing pain, stiffness, and in ristricted movement of neck as well as associated symptoms.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85365585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9526
S. N. Albhar
The purpose of present research work was to develop a Film Forming gel formulation of flurbiprofen using carbopol 934 as a gelling agent for topical delivery with the aim to avoid hepatic first pass metabolism, improve stability of emulsion, reduce dosage regimen and enhance residence time in the treatment of Rheumatoid arthritis. Film Forming gels have emerged as one of the most interesting topical drug delivery systems as it has dual release control i.e. Film and gel. The developed gels were evaluated for their physicochemical properties like color, homogeneity, consistency, spreadability, pH value, rheological behaviour, drug content, drug release and stability. All the prepared film forming gels showed satisfactory physicochemical properties like color, homogeneity, consistency, spreadability, and pH value. The drug release was found to be higher for optimized formulation as compared to the other prepared formulations. The highest drug content was observed with F2, i.e; 98.66%. The drug releases from all the gels were found to follow diffusion-controlled mechanism. Stability studies indicated that the physical appearance, rheological properties, spreadability, drug content in all the prepared gels remained unchanged upon storage for 3 months.
{"title":"FORMULATION AND DEVELOPMENT OF FLURBIPROFEN CONTAINING FILM FORMING GEL","authors":"S. N. Albhar","doi":"10.20959/WJPR201711-9526","DOIUrl":"https://doi.org/10.20959/WJPR201711-9526","url":null,"abstract":"The purpose of present research work was to develop a Film Forming gel formulation of flurbiprofen using carbopol 934 as a gelling agent for topical delivery with the aim to avoid hepatic first pass metabolism, improve stability of emulsion, reduce dosage regimen and enhance residence time in the treatment of Rheumatoid arthritis. Film Forming gels have emerged as one of the most interesting topical drug delivery systems as it has dual release control i.e. Film and gel. The developed gels were evaluated for their physicochemical properties like color, homogeneity, consistency, spreadability, pH value, rheological behaviour, drug content, drug release and stability. All the prepared film forming gels showed satisfactory physicochemical properties like color, homogeneity, consistency, spreadability, and pH value. The drug release was found to be higher for optimized formulation as compared to the other prepared formulations. The highest drug content was observed with F2, i.e; 98.66%. The drug releases from all the gels were found to follow diffusion-controlled mechanism. Stability studies indicated that the physical appearance, rheological properties, spreadability, drug content in all the prepared gels remained unchanged upon storage for 3 months.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72645315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-8897
D. Bhatt
Methicillin-resistant Staphylococcus aureus (MRSA) is a bacteria that is resistant to many antibiotics. Staph and MRSA can cause a variety of problems ranging from are skin infections and sepsis to pneumonia to bloodstream infections. Vancomycin-resistant Staphylococcus aureus (VRSA) is a rare, multidrug-resistant bacterium of public health concern that emerged few decade back. Appropriate antimicrobial prescribing by healthcare providers, adherence to recommended infection control guidelines, and, ultimately, the control of both MRSA and VRSA are necessary to prevent further emergence of VRSA strains. Increased frequency of S. aureus infections imposes a high and increasing burden on healthcare resources. Methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) cause nosocomial infections and are linked with increased rates of illness and death. Common preventive measures when used by health care professional and general public help to reduce infection chances. Appropriate use of right antibiotic lead to decrease chance of evolution of drugs resistance. As of now, all MRSA and VRSA isolates have been susceptible to several Food and Drug Administration (FDA) approved drugs.
{"title":"BRIEF REVIEW ON MRSA AND VRSA","authors":"D. Bhatt","doi":"10.20959/wjpr201711-8897","DOIUrl":"https://doi.org/10.20959/wjpr201711-8897","url":null,"abstract":"Methicillin-resistant Staphylococcus aureus (MRSA) is a bacteria that is resistant to many antibiotics. Staph and MRSA can cause a variety of problems ranging from are skin infections and sepsis to pneumonia to bloodstream infections. Vancomycin-resistant Staphylococcus aureus (VRSA) is a rare, multidrug-resistant bacterium of public health concern that emerged few decade back. Appropriate antimicrobial prescribing by healthcare providers, adherence to recommended infection control guidelines, and, ultimately, the control of both MRSA and VRSA are necessary to prevent further emergence of VRSA strains. Increased frequency of S. aureus infections imposes a high and increasing burden on healthcare resources. Methicillin-resistant staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) cause nosocomial infections and are linked with increased rates of illness and death. Common preventive measures when used by health care professional and general public help to reduce infection chances. Appropriate use of right antibiotic lead to decrease chance of evolution of drugs resistance. As of now, all MRSA and VRSA isolates have been susceptible to several Food and Drug Administration (FDA) approved drugs.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80329866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9523
Kunj Biharee Saini
Tridoshas i.e. Vata, Pitta and Kapha are described as Tristhambha (three main pillars) of Ayurveda–the science of life. Similarly Aahara (food), Nidra (sleep) and Bramhacharya (abstinence) are described to be the Trayopasthambas (three supportive pillars). Hence forth, sleep is one of the essential factors to lead a healthy life. Due to loss of sleep person suffers too many problems related with health. In modern era insomnia may be symptom of stressful lifestyle, depressive illness, anxiety disorder, any psychiatric conditions or any other pathological conditions. Line of management of Nidranasha explained in the different contexts by various Acharyas can be described in detail. Diet modification (milk, Ikshu Ras, Madya, Shalianna, Dadhi),various therapeutic procedure‟s (Senehana, Abhyanga, Samvahan, Murdhnitaila, Padaabhyang, Shirobasti, Shirodhara, Nashaya ), various Ayurvedic medicines (Swarn Makshika Basma, Jahar Mohara Pisti, Nidrodaya Ras, Bramhi Curna, Sarpagandha Churna etc.), Yoga and meditation therapy (Anuloma Viloma, Kapalbhati, Bhramari, Chakrasana, Shirsasana).
{"title":"A CRITICAL STUDY ON NIDRANASH AND ITS AYURVEDIC MANAGEMENT","authors":"Kunj Biharee Saini","doi":"10.20959/WJPR201711-9523","DOIUrl":"https://doi.org/10.20959/WJPR201711-9523","url":null,"abstract":"Tridoshas i.e. Vata, Pitta and Kapha are described as Tristhambha (three main pillars) of Ayurveda–the science of life. Similarly Aahara (food), Nidra (sleep) and Bramhacharya (abstinence) are described to be the Trayopasthambas (three supportive pillars). Hence forth, sleep is one of the essential factors to lead a healthy life. Due to loss of sleep person suffers too many problems related with health. In modern era insomnia may be symptom of stressful lifestyle, depressive illness, anxiety disorder, any psychiatric conditions or any other pathological conditions. Line of management of Nidranasha explained in the different contexts by various Acharyas can be described in detail. Diet modification (milk, Ikshu Ras, Madya, Shalianna, Dadhi),various therapeutic procedure‟s (Senehana, Abhyanga, Samvahan, Murdhnitaila, Padaabhyang, Shirobasti, Shirodhara, Nashaya ), various Ayurvedic medicines (Swarn Makshika Basma, Jahar Mohara Pisti, Nidrodaya Ras, Bramhi Curna, Sarpagandha Churna etc.), Yoga and meditation therapy (Anuloma Viloma, Kapalbhati, Bhramari, Chakrasana, Shirsasana).","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86107662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9622
B. Kumar
Schiff bases, such as nitrofurantoin or nifuroxazide, are commonly applied in medicine as antibacterial agents. They are well known for their biological application as antibacterial, antifungal, antiviral, antiHIV, anti-protozoal, anti-cancer agents. The present paper describes the synthesis of Schiff‟s base 3,4,5-trimethoxy-N[substituted(Aryl/Hetero-Aryl)methylene)benzenamine derivatives 5am from commercially available gallic acid. These derivatives were synthesized by condensation with 3,4,5-trimethoxyanline using various aromatic and hetero-aromatic aldehydes in presence of ZnO Nano particles at room temperature. Furthermore, the present paper describes the green metrics evaluation data for the synthesized Schiff‟s base derivatives (5a-m) and its associated intermediates. In addition to the above, these compounds were screened for their anti-
{"title":"SYNTHESIS, GREEN METRICS EVALUATION AND ANTIBACTERIAL ACTIVITY OF 3,4,5-TRIMETHOXY–N- [SUBSTITUTED (ARYL/HETEROARYL) METHYLENE)BENZENAMINE DERIVATIVES","authors":"B. Kumar","doi":"10.20959/WJPR201711-9622","DOIUrl":"https://doi.org/10.20959/WJPR201711-9622","url":null,"abstract":"Schiff bases, such as nitrofurantoin or nifuroxazide, are commonly applied in medicine as antibacterial agents. They are well known for their biological application as antibacterial, antifungal, antiviral, antiHIV, anti-protozoal, anti-cancer agents. The present paper describes the synthesis of Schiff‟s base 3,4,5-trimethoxy-N[substituted(Aryl/Hetero-Aryl)methylene)benzenamine derivatives 5am from commercially available gallic acid. These derivatives were synthesized by condensation with 3,4,5-trimethoxyanline using various aromatic and hetero-aromatic aldehydes in presence of ZnO Nano particles at room temperature. Furthermore, the present paper describes the green metrics evaluation data for the synthesized Schiff‟s base derivatives (5a-m) and its associated intermediates. In addition to the above, these compounds were screened for their anti-","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86226431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9483
Lec. Assis. Suzan I. Bajilan
This study was conducted to investigate the effect of two concentrations (0.5 and 1ppm) of silver nanoparticles on levels of serum FSH, LH and E2 in PCO-induced female mice. A number(n=80) of mature female mice were intraperitoneally injected with human Chorionic Gonadotropin (hCG) at a dose of (10 IU/ mL) three days a week for two weeks in order to induce PCO. Then, these mice were divided into two groups, according to the duration of treatment (30, 45 days). Each group was subdivided to subgroups according to the substance administrated. Two subgroups were treated with (0.5 and 1ppm) of silver NPs solution by (i.p) injection twice a week and the third subgroup was treated with metformin at a dose of (1mg/day) orally three days a week. Results: there was a significant reduction (P<0.05) in serum levels of FSH in the PCO group treated with (1ppm) of silver NPs for 30 days as compared to the control. While, a significant elevation (P< 0.05) was observed in levels of E2, for the same group as compared to the control. The PCO group treated with (0.5ppm) recorded a significant reduction (P <0.05) in serum levels of E2 for the same duration. But longer duration (45 days) exhibited a significant elevation (P< 0.05) in levels serum of FSH in the PCO-induced mice treated with (0.5ppm) of silver NPs which, was similar to the effect of metformin. A significant elevation (P> 0.05) in serum levels of FSH was observed in the PCO group treated with (0.5ppm) of silver NPs along 30 days as compared to their similar group that was treated along 45 days but, non significant alteration (P> 0.05) were observed in serum levels of LH or E2 between groups of the (30 days) duration as compared to their similar groups of the second duration (45 days). Conclusion: *Corresponding Author Prof. Suzan I. Bajilan College of Nursing, Basic Science Dep. University of Baghdad, Baghdad-Iraq. Article Received on 29 July 2017, Revised on 19 August 2017, Accepted on 10 Sep. 2017 DOI: 10.20959/wjpr201711-9483 World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 113-125. Research Article ISSN 2277– 7105
本实验研究了0.5和1ppm两种浓度的银纳米颗粒对pco诱导雌性小鼠血清FSH、LH和E2水平的影响。80只成熟雌性小鼠，每周3天，连续2周腹腔注射人绒毛膜促性腺激素(hCG)，剂量为(10 IU/ mL)。然后，将这些小鼠根据治疗时间分为两组(30、45天)。每组按给药物质再细分为亚组。两个亚组以(0.5和1ppm) NPs银溶液(i.p)注射治疗，每周2次;第三个亚组以(1mg/天)二甲双胍口服治疗，每周3天。结果:经0.5ppm银NPs处理的PCO组30天血清FSH水平明显低于同类组45天(P < 0.05)，但30天组间血清LH和E2水平与同类组45天(P> 0.05)差异不显著。结论:*通讯作者susan I. Bajilan教授，巴格达大学护理学院，基础科学系，巴格达-伊拉克。文章收于2017年7月29日，修订于2017年8月19日，接受于2017年9月10日DOI: 10.20959/wjpr201711-9483 World Journal of Pharmaceutical Research SJIF影响因子7.523卷6，第11期，113-125。研究论文ISSN 2277 - 7105
{"title":"EFFECT OF SILVER NANOPARTICLES ON LEVELS OF SERUM FSH, LH AND ESTRADIOL IN PCO-INDUCED FEMALE MICE","authors":"Lec. Assis. Suzan I. Bajilan","doi":"10.20959/WJPR201711-9483","DOIUrl":"https://doi.org/10.20959/WJPR201711-9483","url":null,"abstract":"This study was conducted to investigate the effect of two concentrations (0.5 and 1ppm) of silver nanoparticles on levels of serum FSH, LH and E2 in PCO-induced female mice. A number(n=80) of mature female mice were intraperitoneally injected with human Chorionic Gonadotropin (hCG) at a dose of (10 IU/ mL) three days a week for two weeks in order to induce PCO. Then, these mice were divided into two groups, according to the duration of treatment (30, 45 days). Each group was subdivided to subgroups according to the substance administrated. Two subgroups were treated with (0.5 and 1ppm) of silver NPs solution by (i.p) injection twice a week and the third subgroup was treated with metformin at a dose of (1mg/day) orally three days a week. Results: there was a significant reduction (P<0.05) in serum levels of FSH in the PCO group treated with (1ppm) of silver NPs for 30 days as compared to the control. While, a significant elevation (P< 0.05) was observed in levels of E2, for the same group as compared to the control. The PCO group treated with (0.5ppm) recorded a significant reduction (P <0.05) in serum levels of E2 for the same duration. But longer duration (45 days) exhibited a significant elevation (P< 0.05) in levels serum of FSH in the PCO-induced mice treated with (0.5ppm) of silver NPs which, was similar to the effect of metformin. A significant elevation (P> 0.05) in serum levels of FSH was observed in the PCO group treated with (0.5ppm) of silver NPs along 30 days as compared to their similar group that was treated along 45 days but, non significant alteration (P> 0.05) were observed in serum levels of LH or E2 between groups of the (30 days) duration as compared to their similar groups of the second duration (45 days). Conclusion: *Corresponding Author Prof. Suzan I. Bajilan College of Nursing, Basic Science Dep. University of Baghdad, Baghdad-Iraq. Article Received on 29 July 2017, Revised on 19 August 2017, Accepted on 10 Sep. 2017 DOI: 10.20959/wjpr201711-9483 World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 113-125. Research Article ISSN 2277– 7105","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85099505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9380
T. Munawar
Natural drugs play important and vital role in the modern medicine. It is usually used to cure some diseases which may not be treated by conventional medicine. Drugs from the plants are easily available less expensive, safe and efficient and rarely have side effects. The alkaloids, tannins, flavanoids and phenol compounds play a major role in preventing various chronic diseases by a definite physiological action on the human body like anticancer, antimicrobial, antioxidant and anti-diabetic activities. The aim of the present study was to evaluate the phytochemical analysis and antioxidant activity of ethanolic extract of Flowers of Tagetes Erecta and rhizome of Zingiber Officinale. Phytochemical screening was carried out for ethanolic extract revealed the presence of various bioactive components include alkaloids, carbohydrates, proteins and saponins. Antioxidant activity was assayed by the 2,2-Diphenyl1-picrylhydrazyl (DPPH) free radical scavenging activity, nitroblue tetrazolium (NBT) and ferric reducing power (FRAP). In all the assays, stem extract exhibited stronger antioxidant activity than that of flowers. The present results showed antibacterial and antioxidant activity of the extracts was found to be positively associated with the total phenolic and flavonoid content of the extracts.
{"title":"PHYTOCHEMICAL ANALYSIS AND ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACTS OF TAGETES ERECTA AND ZINGIBER OFFICINALE","authors":"T. Munawar","doi":"10.20959/WJPR201711-9380","DOIUrl":"https://doi.org/10.20959/WJPR201711-9380","url":null,"abstract":"Natural drugs play important and vital role in the modern medicine. It is usually used to cure some diseases which may not be treated by conventional medicine. Drugs from the plants are easily available less expensive, safe and efficient and rarely have side effects. The alkaloids, tannins, flavanoids and phenol compounds play a major role in preventing various chronic diseases by a definite physiological action on the human body like anticancer, antimicrobial, antioxidant and anti-diabetic activities. The aim of the present study was to evaluate the phytochemical analysis and antioxidant activity of ethanolic extract of Flowers of Tagetes Erecta and rhizome of Zingiber Officinale. Phytochemical screening was carried out for ethanolic extract revealed the presence of various bioactive components include alkaloids, carbohydrates, proteins and saponins. Antioxidant activity was assayed by the 2,2-Diphenyl1-picrylhydrazyl (DPPH) free radical scavenging activity, nitroblue tetrazolium (NBT) and ferric reducing power (FRAP). In all the assays, stem extract exhibited stronger antioxidant activity than that of flowers. The present results showed antibacterial and antioxidant activity of the extracts was found to be positively associated with the total phenolic and flavonoid content of the extracts.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79674577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9581
M. Vajha
{"title":"TAXONOMICAL AND MEDICINAL PROPERTIES AS WELL AS ADAPTATIONS OF AVICENNIA MARINA (GREY MANGROVE) AT MACHILIPATNAM SEACOAST, ANDHRA PRADESH, INDIA","authors":"M. Vajha","doi":"10.20959/WJPR201711-9581","DOIUrl":"https://doi.org/10.20959/WJPR201711-9581","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80879398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9426
S. Rajbongshi
Objective: To formulate and evaluated sublingual film containing an antianginal drug. Experimental work: Sublingual film of Isosorbide dinitrate was formulated using film coating polymer pullulan and inert plasticizer PEG-400 by solving casting method. 3 2 full factorial design was applied to optimize the formulation. The lower concentration of film forming polymer and higher concentration of plasticizer showing best results were selected as independent variables. Disintegration time (Y1) and % drug release at 1 minute (Y2) and folding endurance (Y3) were selected as dependent variables. The prepared films were evaluated for, disintegration time in vitro drug release, folding endurance and mechanical strength and further optimized batch compared with marketed sublingual tablet. Results: Isosorbide dinitrate sublingual film prepared was found to be fulfilling all the film dosage form. The film compared to sublingual tablet concentration of pullulan (X1) and PEG-400 (X2) significantly affected the disintegration time (Y1) and % of drug release at 1 minute(Y2) and folding endurance (Y3). Regression analysis and numerical optimization were performed to identify the best formulation. Formulation F10 prepared with 223 mg, pullulan 19.5%, PEGWorld Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 493-507. Research Article ISSN 2277– 7105 *Corresponding Author Hardik R. Joshi Master of Pharmacy, LM
目的:研制并评价含抗心绞痛药物舌下膜。实验工作:采用溶铸法制备涂膜聚合物普鲁兰和惰性增塑剂PEG-400配制硝酸异山梨酯舌下膜。采用全因子设计对配方进行优化。选取低浓度成膜聚合物和高浓度增塑剂作为自变量。以崩解时间(Y1)、1分钟释药% (Y2)和折叠时间(Y3)为因变量。对制备的膜进行体外崩解时间、药物释放、折叠耐力和机械强度的评价，并与市售舌下片进行优化。结果:所制备的硝酸异山梨酯舌下膜符合所有膜剂型要求。普兰兰(X1)和PEG-400 (X2)舌下片浓度对其崩解时间(Y1)、1分钟释药率(Y2)和折叠时间(Y3)有显著影响。通过回归分析和数值优化确定了最佳配方。配方F10以223 mg, 19.5%的普鲁兰配制，世界药物研究杂志SJIF影响因子7.523卷6，第11期，493-507。通讯作者:Hardik R. Joshi，药学硕士，硕士
{"title":"FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF SUBLINGUAL FILM OF ISOSORBIDE DINITRATE","authors":"S. Rajbongshi","doi":"10.20959/WJPR201711-9426","DOIUrl":"https://doi.org/10.20959/WJPR201711-9426","url":null,"abstract":"Objective: To formulate and evaluated sublingual film containing an antianginal drug. Experimental work: Sublingual film of Isosorbide dinitrate was formulated using film coating polymer pullulan and inert plasticizer PEG-400 by solving casting method. 3 2 full factorial design was applied to optimize the formulation. The lower concentration of film forming polymer and higher concentration of plasticizer showing best results were selected as independent variables. Disintegration time (Y1) and % drug release at 1 minute (Y2) and folding endurance (Y3) were selected as dependent variables. The prepared films were evaluated for, disintegration time in vitro drug release, folding endurance and mechanical strength and further optimized batch compared with marketed sublingual tablet. Results: Isosorbide dinitrate sublingual film prepared was found to be fulfilling all the film dosage form. The film compared to sublingual tablet concentration of pullulan (X1) and PEG-400 (X2) significantly affected the disintegration time (Y1) and % of drug release at 1 minute(Y2) and folding endurance (Y3). Regression analysis and numerical optimization were performed to identify the best formulation. Formulation F10 prepared with 223 mg, pullulan 19.5%, PEGWorld Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 493-507. Research Article ISSN 2277– 7105 *Corresponding Author Hardik R. Joshi Master of Pharmacy, LM","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90812859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9513
M. Chaitanya
{"title":"FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILMS OF MELOXICAM","authors":"M. Chaitanya","doi":"10.20959/wjpr201711-9513","DOIUrl":"https://doi.org/10.20959/wjpr201711-9513","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84265506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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