Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9656
N. Joy
Periodontal disease causes destruction of adjuvant structures of the teeth predominate in all groups, ethnicities, races and both genders. It is generally agreed that gram negative anaerobic germs residing in periodontal vacuities are responsible for periodontitis. Systemic antibiotic therapy is employed in treating this diseased condition, but it has limited due to the lack of accessibility to periodontopathic organisms in the periodontal pocket. Different modes of local delivery devices are developed to deliver the drug locally into periodontal pits. These controlled intra-pocket devices also help in the maintenance of therapeutic drug concentration for the desired period of time. The goal of this research was to fabricate controlled release dental films, loaded with satranidazole as an antimicrobial agent which consists of a common biodegradable polymer and a co-polymer in different proportions for targeted delivery of drug. About 6 formulations of satranidazole dental inserts were prepared with gelatin as the principle biodegradable polymer and sodium alginate as a co-polymer in different ratios. Formulated periodontal films were then crosslinked with 2% v/v glutaraldehyde for 2 and 4 hours respectively inorder to upgrade the formulations for extended release. The dental inserts produced in such a manner were evaluated for their thickness uniformity, folding endurance, weight uniformity, % drug content, surface pH, swelling index, in-vitro drug release, in-vitro permeation, in-vitro antibacterial activity and stability studies. Based on these findings best film was selected as the one which is fabricated with gelatin and sodium alginate (1:1 ratio) i.e. F2 (2 hour crosslinked strip), since it can deliver the drug over MIC in each day of therapy and it is having an adequate drug content and other necessitate film characteristics. The kinetic models of the formulation F2 (2 hour crosslinked film) was then found and it denoted that the formulation undergoes zero order release kinetics and model fits to Higuchi which is reflective of the diffusion mechanism of World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 1010-1033. Research Article ISSN 2277– 7105 *Corresponding Author Nigil Sebastian Joy Nirmala College of Pharmacy, Muvattupuzha, Kerala, India. Pin686661. Article Received on 02 August 2017, Revised on 22 August 2017, Accepted on 13 Sept. 2017 DOI: 10.20959/wjpr201711-9656
牙周病导致牙齿辅助结构的破坏在所有群体、种族、种族和男女中都占主导地位。人们普遍认为，居住在牙周真空的革兰氏阴性厌氧细菌是导致牙周炎的原因。全身性抗生素治疗用于治疗这种疾病，但由于牙周袋内的牙周病微生物缺乏可及性，它受到限制。开发了不同模式的局部递送装置，将药物局部递送到牙周坑。这些可控制的口袋内装置也有助于维持所需时间内的治疗药物浓度。本研究的目的是制备一种由普通可生物降解聚合物和不同比例的共聚物组成的载沙硝唑抗菌剂控释牙膜，用于靶向给药。以明胶为主要可生物降解聚合物，海藻酸钠为共聚物，按不同比例配制了6种satranidazole牙镶剂。然后将配制好的牙周膜分别与2% v/v的戊二醛交联2和4小时，以提高配方的缓释效果。以这种方式生产的牙植入物对其厚度均匀性、折叠耐久性、重量均匀性、药物含量%、表面pH、膨胀指数、体外药物释放、体外渗透、体外抗菌活性和稳定性进行了评估。根据这些发现，最佳薄膜被选择为由明胶和海藻酸钠(1:1比例)制成的，即F2(2小时交联带)，因为它可以在每天的治疗中通过MIC传递药物，并且具有足够的药物含量和其他必要的薄膜特性。建立了F2(2小时交联膜)配方的动力学模型，表明该配方为零级释放动力学，模型符合Higuchi，反映了《World Journal of Pharmaceutical Research》SJIF影响因子7.523 vol . 6, Issue 11, 1010-1033的扩散机理。研究论文ISSN 2277 - 7105 *通讯作者Nigil Sebastian Joy Nirmala药学院，Muvattupuzha, Kerala，印度。Pin686661。文章收于2017年8月2日，修订于2017年8月22日，收于2017年9月13日DOI: 10.20959/wjpr201711-9656
{"title":"DEVELOPMENT AND ASSESSMENT OF AN ANTIBIOTIC INTRAPOCKET DEVICE FOR PERIODONTAL DISEASE","authors":"N. Joy","doi":"10.20959/wjpr201711-9656","DOIUrl":"https://doi.org/10.20959/wjpr201711-9656","url":null,"abstract":"Periodontal disease causes destruction of adjuvant structures of the teeth predominate in all groups, ethnicities, races and both genders. It is generally agreed that gram negative anaerobic germs residing in periodontal vacuities are responsible for periodontitis. Systemic antibiotic therapy is employed in treating this diseased condition, but it has limited due to the lack of accessibility to periodontopathic organisms in the periodontal pocket. Different modes of local delivery devices are developed to deliver the drug locally into periodontal pits. These controlled intra-pocket devices also help in the maintenance of therapeutic drug concentration for the desired period of time. The goal of this research was to fabricate controlled release dental films, loaded with satranidazole as an antimicrobial agent which consists of a common biodegradable polymer and a co-polymer in different proportions for targeted delivery of drug. About 6 formulations of satranidazole dental inserts were prepared with gelatin as the principle biodegradable polymer and sodium alginate as a co-polymer in different ratios. Formulated periodontal films were then crosslinked with 2% v/v glutaraldehyde for 2 and 4 hours respectively inorder to upgrade the formulations for extended release. The dental inserts produced in such a manner were evaluated for their thickness uniformity, folding endurance, weight uniformity, % drug content, surface pH, swelling index, in-vitro drug release, in-vitro permeation, in-vitro antibacterial activity and stability studies. Based on these findings best film was selected as the one which is fabricated with gelatin and sodium alginate (1:1 ratio) i.e. F2 (2 hour crosslinked strip), since it can deliver the drug over MIC in each day of therapy and it is having an adequate drug content and other necessitate film characteristics. The kinetic models of the formulation F2 (2 hour crosslinked film) was then found and it denoted that the formulation undergoes zero order release kinetics and model fits to Higuchi which is reflective of the diffusion mechanism of World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 1010-1033. Research Article ISSN 2277– 7105 *Corresponding Author Nigil Sebastian Joy Nirmala College of Pharmacy, Muvattupuzha, Kerala, India. Pin686661. Article Received on 02 August 2017, Revised on 22 August 2017, Accepted on 13 Sept. 2017 DOI: 10.20959/wjpr201711-9656","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"159 1","pages":"1010-1033"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75167580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9585
A. Maan
{"title":"EFFECT OF INJ. KENACORT IN THE MANAGEMENT OF FROZEN SHOULDER","authors":"A. Maan","doi":"10.20959/WJPR201711-9585","DOIUrl":"https://doi.org/10.20959/WJPR201711-9585","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"75 5","pages":"853-858"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91421594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9575
Eze Charity Chinasa
The attention of the pharmaceutical scientists has been drawn to studies on the potential antimicrobial activities of plant derived substances, an untapped source of antimicrobials which are used in traditional medicine in different settings. This led to the study of the phytochemical analysis and antimicrobial activity of the methanol leaf extract of Luffa cylindrica on certain pathogenic microbes: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi, Candida albicans, Aspergillus niger, which were isolated from the laboratory benches and toilet handles of the Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University Awka. The percentage Ash value was determined to be 2.3%. Microscopic evaluation of the plant showed specific cellular structures like the parenchyma, oxalate crystals, epidermal hairs and stomata. S. aureus, S. typhi, P. aeruginosa and C. albicans were susceptible to the methanol leaf extract of L. cylindrica, with the exception of E. coli and A. niger which were resistant to the methanol extract. The phytochemical compounds present are Flavonoids, Alkaloids, Saponins, World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 17-41. Review Article ISSN 2277– 7105 *Corresponding Author Dr. Ezea Charity Chinasa Department of
{"title":"PHYTOCHEMICAL ANALYSIS AND ANTIMICROBIAL ACTIVITY OF THE METHANOL LEAF EXTRACT OF LUFFA CYLINDRICA ON CERTAIN PATHOGENIC MICROBES.","authors":"Eze Charity Chinasa","doi":"10.20959/WJPR201711-9575","DOIUrl":"https://doi.org/10.20959/WJPR201711-9575","url":null,"abstract":"The attention of the pharmaceutical scientists has been drawn to studies on the potential antimicrobial activities of plant derived substances, an untapped source of antimicrobials which are used in traditional medicine in different settings. This led to the study of the phytochemical analysis and antimicrobial activity of the methanol leaf extract of Luffa cylindrica on certain pathogenic microbes: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi, Candida albicans, Aspergillus niger, which were isolated from the laboratory benches and toilet handles of the Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University Awka. The percentage Ash value was determined to be 2.3%. Microscopic evaluation of the plant showed specific cellular structures like the parenchyma, oxalate crystals, epidermal hairs and stomata. S. aureus, S. typhi, P. aeruginosa and C. albicans were susceptible to the methanol leaf extract of L. cylindrica, with the exception of E. coli and A. niger which were resistant to the methanol extract. The phytochemical compounds present are Flavonoids, Alkaloids, Saponins, World Journal of Pharmaceutical Research SJIF Impact Factor 7.523 Volume 6, Issue 11, 17-41. Review Article ISSN 2277– 7105 *Corresponding Author Dr. Ezea Charity Chinasa Department of","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"12 1","pages":"17-41"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91546032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9543
R. Kumawat
Hemoglobin deficiency is a global public health problem affecting both developing and developed countries with major consequences for human health as well as social and economic development. It occurs at all stages of the life cycle, but is more prevalent in pregnant women and young children. On an average, globally 50% of the anemia is assumed to be attributed to iron deficiency. It is very common in rural population due to poverty and inadequate diet. Iron deficiency is primarily caused due to dietary insufficiency; therefore, this study aims to explore locally available dietary iron sources. The central hypothesis of the study being a low cost, locally available and culturally acceptable dietary substance supplementing adequate iron requirement will have a better chance of compliance in the population. A single blind Study was carried out in OPD patients of DG department of NIA, Jaipur for 30 days. Total 20 apparently healthy volunteers were registered for the trial and treated with Vastuka dry powder. The overall clinical improvement was highly significant.
{"title":"THE EFFECT OF VASTUKA (CHENOPODIUM ALBUM LINN.) ON BLOOD HEMOGLOBIN LEVEL: A RESEARCH STUDY","authors":"R. Kumawat","doi":"10.20959/WJPR201711-9543","DOIUrl":"https://doi.org/10.20959/WJPR201711-9543","url":null,"abstract":"Hemoglobin deficiency is a global public health problem affecting both developing and developed countries with major consequences for human health as well as social and economic development. It occurs at all stages of the life cycle, but is more prevalent in pregnant women and young children. On an average, globally 50% of the anemia is assumed to be attributed to iron deficiency. It is very common in rural population due to poverty and inadequate diet. Iron deficiency is primarily caused due to dietary insufficiency; therefore, this study aims to explore locally available dietary iron sources. The central hypothesis of the study being a low cost, locally available and culturally acceptable dietary substance supplementing adequate iron requirement will have a better chance of compliance in the population. A single blind Study was carried out in OPD patients of DG department of NIA, Jaipur for 30 days. Total 20 apparently healthy volunteers were registered for the trial and treated with Vastuka dry powder. The overall clinical improvement was highly significant.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"1 1","pages":"702-708"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90625253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9501
G. Tewari
{"title":"A REVIEW ON AROMA PROFILE OF CINNAMOMUM SPECIES IN NORTH AND NORTH EAST INDIA","authors":"G. Tewari","doi":"10.20959/WJPR201711-9501","DOIUrl":"https://doi.org/10.20959/WJPR201711-9501","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"79 1","pages":"200-221"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88252458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/wjpr201711-9497
R. Savitha
Intestinal worm infection is a common pediatric health problem causing morbidity and anguish. Sadhakuppai Chooranam is a traditional Siddha drug indicated for Kudal kirumi (Ascariasis) a common ailment among children. The current study was conducted among 40 pediatric patients (30 Out Patients and 10 In Patients) of the department of Kuzhanthai Maruthuvam at National institute of Siddha, Tambaram, Chennai. The trial drug Sadhakuppai Chooranam was given twice a day for 20 days and follow up was done once in 7 days. At each clinical visit clinical assessment was done and prognosis was noted. Laboratory investigations were done 0 day & 20th day of the trial, and the patients were followed up for another 2 months. The study data were circumspectly analyzed and are presented graphically in this work. The study results revealed that among the forty patients enrolled in the open labeled pilot study, 80% of them had very good prognosis with improvement in both clinical and laboratory parameters. Hence the trial drug Sadhakuppai Chooranam can be used clinically for the effective treatment of Kudal kirumi (Ascariasis).
{"title":"AN OPEN LABELLED PILOT STUDY ON THE EFFICACY OF SIDDHA FORMULATION SADHAKUPPAI CHOORANAM FOR THE TREATMENT OF KUDAL KIRUMI (ASCARIASIS)","authors":"R. Savitha","doi":"10.20959/wjpr201711-9497","DOIUrl":"https://doi.org/10.20959/wjpr201711-9497","url":null,"abstract":"Intestinal worm infection is a common pediatric health problem causing morbidity and anguish. Sadhakuppai Chooranam is a traditional Siddha drug indicated for Kudal kirumi (Ascariasis) a common ailment among children. The current study was conducted among 40 pediatric patients (30 Out Patients and 10 In Patients) of the department of Kuzhanthai Maruthuvam at National institute of Siddha, Tambaram, Chennai. The trial drug Sadhakuppai Chooranam was given twice a day for 20 days and follow up was done once in 7 days. At each clinical visit clinical assessment was done and prognosis was noted. Laboratory investigations were done 0 day & 20th day of the trial, and the patients were followed up for another 2 months. The study data were circumspectly analyzed and are presented graphically in this work. The study results revealed that among the forty patients enrolled in the open labeled pilot study, 80% of them had very good prognosis with improvement in both clinical and laboratory parameters. Hence the trial drug Sadhakuppai Chooranam can be used clinically for the effective treatment of Kudal kirumi (Ascariasis).","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"25 1","pages":"546-552"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88379399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-11-01DOI: 10.20959/WJPR201711-9544
Sarina.P. Khabade
{"title":"PURIFICATION AND CHARACTERIZATION OF L-ASPARGINASE ENZYME FROM SPINACEA OLERACEA","authors":"Sarina.P. Khabade","doi":"10.20959/WJPR201711-9544","DOIUrl":"https://doi.org/10.20959/WJPR201711-9544","url":null,"abstract":"","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"17 1","pages":"709-717"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86420840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-01DOI: 10.20959/WJPR201710-8982
Amrapali S. Kakade
The aim of present study was Evaluation of Wound Healing activity of Polyherbal Gel Formulation. The different concentration of gel was prepared by using corbopol 940 as a gel base. Azadirachta Indica leaves extract, Tridax procumbens leaves extract, and honey by using partial thickness burn wound model in winster rats. All animals were divided into six groups. Group I was control, Group II was treated by 1% of Azadirachta Indica gel, Group III was treated by 1% of Tridax procumbens gel, Group IV were treated by 1% Honey gel . Group V were treated by polyherbal gel and Group IV were treated by Marketed Preparetion (Reference Standard). For 15 days all gel applied topically. The wound healing activity evaluated by physical parameters namely wound contraction and epithelialization. The polyherbal gel shows significant effect on wound healing activity.
{"title":"EVALUATION OF WOUND HEALING ACTIVITY OF POLYHERBAL GEL FORMULATION","authors":"Amrapali S. Kakade","doi":"10.20959/WJPR201710-8982","DOIUrl":"https://doi.org/10.20959/WJPR201710-8982","url":null,"abstract":"The aim of present study was Evaluation of Wound Healing activity of Polyherbal Gel Formulation. The different concentration of gel was prepared by using corbopol 940 as a gel base. Azadirachta Indica leaves extract, Tridax procumbens leaves extract, and honey by using partial thickness burn wound model in winster rats. All animals were divided into six groups. Group I was control, Group II was treated by 1% of Azadirachta Indica gel, Group III was treated by 1% of Tridax procumbens gel, Group IV were treated by 1% Honey gel . Group V were treated by polyherbal gel and Group IV were treated by Marketed Preparetion (Reference Standard). For 15 days all gel applied topically. The wound healing activity evaluated by physical parameters namely wound contraction and epithelialization. The polyherbal gel shows significant effect on wound healing activity.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"86 1","pages":"501-509"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78198469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-10-01DOI: 10.20959/WJPR201710-9441
M. Bhavani
Rasa Shastra has been serving humanity from centuries with its unique metallic and herbo-mineral formulations. Prameha is one among the 8 Mahagadas as numerated by our Acharyas. The syndrome Diabetes mellitus has been largely covered under the broad heading of Prameha. Diabetes mellitus is a metabolic disorder of carbohydrate, fat & protein characterized by hyperglycemia with or without glycosuria. According to the International Diabetic Federation (IDF), the disease affects 285 million people of the world‟s population in the 20 – 79 years age group and this number is expected to grow to 380 million by 2025. Rajata Yoga is mentioned in Rasa Tarangini and indicated in all types of Prameha. Rajata bhasma and Trijataka churna are the main ingredients of Rajata Yoga. Its clinical efficacy was evaluated in 30 patients of Prameha based on the signs and symptoms mentioned in classics. Rajata Yoga showed statistically extremely significant relief (p<0.0001) in Prabhuta mutrata, Avila mutrata, Karapada daha & suptata, Dourbalya, Kruchravyavayata, Pindikodveshtana, FBS, PPBS. It showed very significant relief (p< 0.001) in Sweda atipravrutti and significant relief in (p<0.05) in Pipasaadhikyata, Kshudaadhikyata.
{"title":"EVALUATION OF CLINICAL EFFICACY OF RAJATA YOGA IN PRAMEHA W.S.R. TO DIABETES MELLITUS","authors":"M. Bhavani","doi":"10.20959/WJPR201710-9441","DOIUrl":"https://doi.org/10.20959/WJPR201710-9441","url":null,"abstract":"Rasa Shastra has been serving humanity from centuries with its unique metallic and herbo-mineral formulations. Prameha is one among the 8 Mahagadas as numerated by our Acharyas. The syndrome Diabetes mellitus has been largely covered under the broad heading of Prameha. Diabetes mellitus is a metabolic disorder of carbohydrate, fat & protein characterized by hyperglycemia with or without glycosuria. According to the International Diabetic Federation (IDF), the disease affects 285 million people of the world‟s population in the 20 – 79 years age group and this number is expected to grow to 380 million by 2025. Rajata Yoga is mentioned in Rasa Tarangini and indicated in all types of Prameha. Rajata bhasma and Trijataka churna are the main ingredients of Rajata Yoga. Its clinical efficacy was evaluated in 30 patients of Prameha based on the signs and symptoms mentioned in classics. Rajata Yoga showed statistically extremely significant relief (p<0.0001) in Prabhuta mutrata, Avila mutrata, Karapada daha & suptata, Dourbalya, Kruchravyavayata, Pindikodveshtana, FBS, PPBS. It showed very significant relief (p< 0.001) in Sweda atipravrutti and significant relief in (p<0.05) in Pipasaadhikyata, Kshudaadhikyata.","PeriodicalId":23796,"journal":{"name":"World journal of pharmaceutical research","volume":"1 1","pages":"1079-1089"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78384186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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