Pub Date : 2025-10-10DOI: 10.1016/j.cis.2025.103685
Sara Abdulwahab , Nursakinah Suardi , Mohammed Ali Dheyab , Wesam Abdullah , Azlan Abdul Aziz , Saleh T. Alanezi , Mutaz Mohammad Alsardi , Mothana Hussein Tarawneh , Mehran Ghasemlou
Nanoemulsions are a distinct subclass of emulsions that have sparked increasing interest in pharmaceutical, cosmetic, and food sectors due to their increased specific surface area, high stability, tunable release profiles, and good oral bioavailability. Green nanoemulsions, with ingredients entirely from plant or microbial sources, are a conceptually new frontier for next generation nanoproducts. Engineering a kinetically stable green nanoemulsion system for tailored applications entails a systematic understanding of the critical properties of the biosurfactants. This review delivers a holistic and mechanistic exploration of green nanoemulsion systems, with greater focus on bio-derived surfactants and low-energy fabrication methods. We critically discuss how the interfacial behavior and physiochemical properties of surfactants can govern the stability of nanoemulsions. Particular emphasis is devoted to unveiling the untapped capacity of biosurfactants in modulating drug encapsulation, biodegradability, and controlled release across chemical, medical, food, cosmetic and agricultural industries. Emerging emulsion platforms, such as Pickering and stimuli-responsive nanoemulsions, that can respond to either a single stimulus or multiple stimuli, are also highlighted. By bridging interfacial science with translational medicine, this review can act as a roadmap to steer researchers toward the tailored design of green nanoemulsions for unforeseeable applications in bioimaging, drug delivery, and cancer therapy.
{"title":"Functional green nanoemulsions with biosurfactants: Synthesis, surface engineering and advanced food, cosmetic, agricultural and biomedical applications","authors":"Sara Abdulwahab , Nursakinah Suardi , Mohammed Ali Dheyab , Wesam Abdullah , Azlan Abdul Aziz , Saleh T. Alanezi , Mutaz Mohammad Alsardi , Mothana Hussein Tarawneh , Mehran Ghasemlou","doi":"10.1016/j.cis.2025.103685","DOIUrl":"10.1016/j.cis.2025.103685","url":null,"abstract":"<div><div>Nanoemulsions are a distinct subclass of emulsions that have sparked increasing interest in pharmaceutical, cosmetic, and food sectors due to their increased specific surface area, high stability, tunable release profiles, and good oral bioavailability. Green nanoemulsions, with ingredients entirely from plant or microbial sources, are a conceptually new frontier for next generation nanoproducts. Engineering a kinetically stable green nanoemulsion system for tailored applications entails a systematic understanding of the critical properties of the biosurfactants. This review delivers a holistic and mechanistic exploration of green nanoemulsion systems, with greater focus on bio-derived surfactants and low-energy fabrication methods. We critically discuss how the interfacial behavior and physiochemical properties of surfactants can govern the stability of nanoemulsions. Particular emphasis is devoted to unveiling the untapped capacity of biosurfactants in modulating drug encapsulation, biodegradability, and controlled release across chemical, medical, food, cosmetic and agricultural industries. Emerging emulsion platforms, such as Pickering and stimuli-responsive nanoemulsions, that can respond to either a single stimulus or multiple stimuli, are also highlighted. By bridging interfacial science with translational medicine, this review can act as a roadmap to steer researchers toward the tailored design of green nanoemulsions for unforeseeable applications in bioimaging, drug delivery, and cancer therapy.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103685"},"PeriodicalIF":19.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-10DOI: 10.1016/j.cis.2025.103687
Haizhuang Jiang , Hongbin Yang , Xiangfeng Zhang , Wanli Kang , Ruichao Wang , Haocong Li , Shuhe Zhang , Xin Chen , Liang Peng , Haobin Shi , Bauyrzhan Sarsenbekuly
Water flooding is widely employed as the core technology for secondary oil recovery, aimed at supplementing reservoir energy and displacing crude oil to enhance recovery efficiency. However, inherent reservoir heterogeneity (e.g., high-permeability layers, fractures, and cavernous) frequently results in a rapid rise and persistently high water cut in production wells, rendering the remaining oil difficult to be displaced. Deep profile control technology is recognized as a key method for mitigating water channeling and improving water flooding performance. Its principle is based on the blockage of preferential flow channels within high-permeability zones, thereby regulating the subsequent water injection profile. This technology has been extensively applied in reservoirs exhibiting high and ultra-high water cuts. Polymer microspheres have emerged as significant chemical agents for deep profile control systems due to their exceptional elastic deformability. Their mechanism of action is characterized as follows: the microspheres are transported deep into the reservoir formation along with the injected fluid. Leveraging their smart deformable characteristics, they dynamically adapt to pore throat structures of varying sizes. They are preferentially retained and accumulated within the preferential flow channels (characterized by lower flow resistance), where effective plugging is formed. Consequently, subsequent displacing fluids are forced to divert towards and sweep low-permeability zones that were previously non swept by water flooding and possess higher oil saturation. This unique combination of deep migration and intelligent deformable plugging effectively overcomes the limitations of traditional rigid particle plugging agents, which are often difficult to transport deep into the reservoir or prone to causing excessive near-wellbore blockage. Consequently, the sweep volume and oil displacement efficiency of the displacing fluid within heterogeneous reservoirs are significantly enhanced, ultimately leading to increased crude oil recovery. Nevertheless, despite abundant research achievements on polymer microspheres, the current knowledge landscape is characterized by fragmentation and dispersion. A systematic integration is lacking, particularly concerning the establishment of an organic link between structural design, performance regulation, mechanism of action, and practical application effectiveness. Therefore, this study is designed to systematically synthesize the knowledge on polymer microspheres for deep profile control from the following three aspects: (1) Function-Structure-Mechanism Correlation: The intrinsic correlations between chemical modification strategies for functionalized polymer microspheres and their enhanced performance are systematically revealed. (2) Synergistic Mechanisms in Heterogeneous Composite Systems: The profile control performance and synergistic enhancement mechanisms of heterogeneous composite systems ba
{"title":"Advances of polymer microsphere and its application in porous media for enhanced oil recovery","authors":"Haizhuang Jiang , Hongbin Yang , Xiangfeng Zhang , Wanli Kang , Ruichao Wang , Haocong Li , Shuhe Zhang , Xin Chen , Liang Peng , Haobin Shi , Bauyrzhan Sarsenbekuly","doi":"10.1016/j.cis.2025.103687","DOIUrl":"10.1016/j.cis.2025.103687","url":null,"abstract":"<div><div>Water flooding is widely employed as the core technology for secondary oil recovery, aimed at supplementing reservoir energy and displacing crude oil to enhance recovery efficiency. However, inherent reservoir heterogeneity (e.g., high-permeability layers, fractures, and cavernous) frequently results in a rapid rise and persistently high water cut in production wells, rendering the remaining oil difficult to be displaced. Deep profile control technology is recognized as a key method for mitigating water channeling and improving water flooding performance. Its principle is based on the blockage of preferential flow channels within high-permeability zones, thereby regulating the subsequent water injection profile. This technology has been extensively applied in reservoirs exhibiting high and ultra-high water cuts. Polymer microspheres have emerged as significant chemical agents for deep profile control systems due to their exceptional elastic deformability. Their mechanism of action is characterized as follows: the microspheres are transported deep into the reservoir formation along with the injected fluid. Leveraging their smart deformable characteristics, they dynamically adapt to pore throat structures of varying sizes. They are preferentially retained and accumulated within the preferential flow channels (characterized by lower flow resistance), where effective plugging is formed. Consequently, subsequent displacing fluids are forced to divert towards and sweep low-permeability zones that were previously non swept by water flooding and possess higher oil saturation. This unique combination of deep migration and intelligent deformable plugging effectively overcomes the limitations of traditional rigid particle plugging agents, which are often difficult to transport deep into the reservoir or prone to causing excessive near-wellbore blockage. Consequently, the sweep volume and oil displacement efficiency of the displacing fluid within heterogeneous reservoirs are significantly enhanced, ultimately leading to increased crude oil recovery. Nevertheless, despite abundant research achievements on polymer microspheres, the current knowledge landscape is characterized by fragmentation and dispersion. A systematic integration is lacking, particularly concerning the establishment of an organic link between structural design, performance regulation, mechanism of action, and practical application effectiveness. Therefore, this study is designed to systematically synthesize the knowledge on polymer microspheres for deep profile control from the following three aspects: (1) Function-Structure-Mechanism Correlation: The intrinsic correlations between chemical modification strategies for functionalized polymer microspheres and their enhanced performance are systematically revealed. (2) Synergistic Mechanisms in Heterogeneous Composite Systems: The profile control performance and synergistic enhancement mechanisms of heterogeneous composite systems ba","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103687"},"PeriodicalIF":19.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145294599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-10DOI: 10.1016/j.cis.2025.103686
Elnaz Karimi, Stefan Iglauer, Muhammad Rizwan Azhar
Solid-state batteries (SSBs) represent a transformative advancement in energy storage, offering superior safety, higher energy density and extended cycle life compared to conventional lithium-ion batteries (LIBs). However, challenges related to interface engineering—particularly in ensuring stable electrochemical performance and preventing lithium dendrite formation—have hindered their widespread adoption and can compromise safety. Effective interface engineering is critical for mitigating interfacial resistance, enhancing mechanical stability and preventing thermal runaway, all of which are vital for improving battery reliability. The integration of artificial intelligence (AI) and machine learning (ML) in this context accelerates battery optimization by enabling predictive modelling of interfacial behaviour, material discovery and strategies to prevent failure. By addressing these fundamental challenges, interface engineering, alongside AI-driven innovations, can play a pivotal role in ensuring the safe, long-term operation of SSBs, providing the foundation for their commercialization in applications such as electric vehicles (EVs) and grid-scale energy storage.
{"title":"Interface engineering and safety in solid-state batteries: Advancing from human-centered insights to AI-driven innovations","authors":"Elnaz Karimi, Stefan Iglauer, Muhammad Rizwan Azhar","doi":"10.1016/j.cis.2025.103686","DOIUrl":"10.1016/j.cis.2025.103686","url":null,"abstract":"<div><div>Solid-state batteries (SSBs) represent a transformative advancement in energy storage, offering superior safety, higher energy density and extended cycle life compared to conventional lithium-ion batteries (LIBs). However, challenges related to interface engineering—particularly in ensuring stable electrochemical performance and preventing lithium dendrite formation—have hindered their widespread adoption and can compromise safety. Effective interface engineering is critical for mitigating interfacial resistance, enhancing mechanical stability and preventing thermal runaway, all of which are vital for improving battery reliability. The integration of artificial intelligence (AI) and machine learning (ML) in this context accelerates battery optimization by enabling predictive modelling of interfacial behaviour, material discovery and strategies to prevent failure. By addressing these fundamental challenges, interface engineering, alongside AI-driven innovations, can play a pivotal role in ensuring the safe, long-term operation of SSBs, providing the foundation for their commercialization in applications such as electric vehicles (EVs) and grid-scale energy storage.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103686"},"PeriodicalIF":19.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-09DOI: 10.1016/j.cis.2025.103684
Antonio Rubio-Andrés, Delfi Bastos-González, Miguel Angel Fernandez-Rodriguez
Nanostructured surfaces have gained significant attention over recent decades due to their diverse technological applications across multiple fields. The fabrication of artificial nanostructures typically relies on lithographic approaches, yet conventional lithography techniques face challenges related to scalability and high costs, prompting the emergence of soft colloidal lithography (SCL) as a promising alternative for designing large-scale crystalline nanostructures. SCL exploits the rapid and large scale self-assembly of microgels at fluid interfaces and their subsequent transfer to solid substrates. Despite its potential, SCL remains underused in most clean room facilities, hindering its implementation in industrial processes. This review addresses this gap by providing both soft matter and materials science communities with tools to effectively design SCL-based materials. We start presenting an updated overview of microgel behavior at fluid interfaces, which is the platform providing the better tools to tune the final monolayer pattern. We then present a comprehensive guidance on preparation procedures, encompassing both direct assembly methods and interface-assisted approaches. Finally, we review applications of SCL-fabricated materials, including those where deposited microgels serve as functional elements and those where monolayers function as either positive masks for nanowire fabrication or negative masks for nanohole production. Throughout the review, we identify promising research directions to advance the SCL technique and propose applications where this methodology could enhance existing technologies.
{"title":"A guide to soft colloidal lithography: Advances in microgels at fluid interfaces, preparation methods and applications of 2D microgel monolayers","authors":"Antonio Rubio-Andrés, Delfi Bastos-González, Miguel Angel Fernandez-Rodriguez","doi":"10.1016/j.cis.2025.103684","DOIUrl":"10.1016/j.cis.2025.103684","url":null,"abstract":"<div><div>Nanostructured surfaces have gained significant attention over recent decades due to their diverse technological applications across multiple fields. The fabrication of artificial nanostructures typically relies on lithographic approaches, yet conventional lithography techniques face challenges related to scalability and high costs, prompting the emergence of soft colloidal lithography (SCL) as a promising alternative for designing large-scale crystalline nanostructures. SCL exploits the rapid and large scale self-assembly of microgels at fluid interfaces and their subsequent transfer to solid substrates. Despite its potential, SCL remains underused in most clean room facilities, hindering its implementation in industrial processes. This review addresses this gap by providing both soft matter and materials science communities with tools to effectively design SCL-based materials. We start presenting an updated overview of microgel behavior at fluid interfaces, which is the platform providing the better tools to tune the final monolayer pattern. We then present a comprehensive guidance on preparation procedures, encompassing both direct assembly methods and interface-assisted approaches. Finally, we review applications of SCL-fabricated materials, including those where deposited microgels serve as functional elements and those where monolayers function as either positive masks for nanowire fabrication or negative masks for nanohole production. Throughout the review, we identify promising research directions to advance the SCL technique and propose applications where this methodology could enhance existing technologies.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103684"},"PeriodicalIF":19.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The convergence of inorganic and organic materials at the nanoscale has led to the development of hybrid nanoarchitectonics with unparalleled properties for biomedical applications. These hybrid nanomaterials leverage the synergistic effects of their constituent components to create sophisticated structures capable of addressing complex biomedical challenges. This review provides a comprehensive overview of the state-of-the-art in inorganic and organic hybrid nanoarchitectonics, focusing on their design principles, synthesis methods, and applications in areas such as drug delivery, biosensing, and bioimaging. We discuss the critical factors that influence the biocompatibility, stability, and functionality of these materials and the strategies employed to enhance their performance. Finally, we highlight the current limitations and future perspectives of hybrid nanoarchitectonics in biomedical research, with the aim of inspiring innovative solutions for precision medicine and improved patient care.
{"title":"Inorganic and organic hybrid nanoarchitectonics for biomedical application","authors":"Xiaoming Zhang , Zhanyao Xu , Yuxian Wei , Wei Qi , Junbai Li","doi":"10.1016/j.cis.2025.103682","DOIUrl":"10.1016/j.cis.2025.103682","url":null,"abstract":"<div><div>The convergence of inorganic and organic materials at the nanoscale has led to the development of hybrid nanoarchitectonics with unparalleled properties for biomedical applications. These hybrid nanomaterials leverage the synergistic effects of their constituent components to create sophisticated structures capable of addressing complex biomedical challenges. This review provides a comprehensive overview of the state-of-the-art in inorganic and organic hybrid nanoarchitectonics, focusing on their design principles, synthesis methods, and applications in areas such as drug delivery, biosensing, and bioimaging. We discuss the critical factors that influence the biocompatibility, stability, and functionality of these materials and the strategies employed to enhance their performance. Finally, we highlight the current limitations and future perspectives of hybrid nanoarchitectonics in biomedical research, with the aim of inspiring innovative solutions for precision medicine and improved patient care.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103682"},"PeriodicalIF":19.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-30DOI: 10.1016/j.cis.2025.103683
Mohammad Mahdi Rostamabadi , Fuat Topuz , Hadis Rostamabadi , Seid Mahdi Jafari
Food protein-based amyloid fibrils (PAFs) represent a novel and sustainable class of functional nanomaterials with growing importance in the design of soft matter systems. Derived from abundant, renewable, and often by-product protein sources, PAFs offer a sustainable/biodegradable alternative to synthetic nanomaterials, combining eco-friendly production with versatile functional applications. Through precise control of environmental factors such as pH, temperature, and ionic strength, diverse food proteins can be transformed into highly ordered fibrillar structures, exhibiting robust mechanical properties, remarkable surface activity, and structural anisotropy. These unique features have positioned PAFs as promising agents for stabilizing emulsions and foams, enhancing the textural properties of hydrogels, and serving as active components in food packaging and biomedical carriers. Their biocompatibility and the presence of modifiable surface groups enable effective encapsulation of bioactive compounds and responsive release under targeted conditions. As research advances, deeper understanding of their formation pathways, physicochemical behaviour, and interaction with other biopolymers will expand their utility across food science, material engineering, and therapeutic delivery systems. This review offers a comprehensive overview of recent insights and emerging strategies in the development and application of PAFs, emphasizing their role in shaping the future of environmentally conscious material innovation.
{"title":"Progress and innovations in food protein amyloid fibrils for fabricating cutting-edge soft materials","authors":"Mohammad Mahdi Rostamabadi , Fuat Topuz , Hadis Rostamabadi , Seid Mahdi Jafari","doi":"10.1016/j.cis.2025.103683","DOIUrl":"10.1016/j.cis.2025.103683","url":null,"abstract":"<div><div>Food protein-based amyloid fibrils (PAFs) represent a novel and sustainable class of functional nanomaterials with growing importance in the design of soft matter systems. Derived from abundant, renewable, and often by-product protein sources, PAFs offer a sustainable/biodegradable alternative to synthetic nanomaterials, combining eco-friendly production with versatile functional applications. Through precise control of environmental factors such as pH, temperature, and ionic strength, diverse food proteins can be transformed into highly ordered fibrillar structures, exhibiting robust mechanical properties, remarkable surface activity, and structural anisotropy. These unique features have positioned PAFs as promising agents for stabilizing emulsions and foams, enhancing the textural properties of hydrogels, and serving as active components in food packaging and biomedical carriers. Their biocompatibility and the presence of modifiable surface groups enable effective encapsulation of bioactive compounds and responsive release under targeted conditions. As research advances, deeper understanding of their formation pathways, physicochemical behaviour, and interaction with other biopolymers will expand their utility across food science, material engineering, and therapeutic delivery systems. This review offers a comprehensive overview of recent insights and emerging strategies in the development and application of PAFs, emphasizing their role in shaping the future of environmentally conscious material innovation.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103683"},"PeriodicalIF":19.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-29DOI: 10.1016/j.cis.2025.103681
Carmen Alvarez-Lorenzo, Angel Concheiro
Scaffolds used in regenerative medicine are increasingly expected to address personalization, bioactivity, and sustainability, underscoring the need for characterization methods that reliably predict safety and efficacy. Isothermal microcalorimetry (IMC) offers a highly sensitive, label-free, real-time measurement of heat flow from energy-generating or -consuming process at scaffold interfaces. By monitoring microbial activity, host cell metabolism, material stability, and responses to environmental or therapeutic factors, IMC provides physiologically relevant insight into scaffold performance over extended periods. Its non-destructive, low-preparation, and passive nature preserves samples for complementary analyses, making it a versatile yet underutilized tool in biomedical research. This review introduces IMC for scaffold design and characterization, emphasizing its capacity to evaluate vulnerability to biofilm formation and the effectiveness of anti-biofilm strategies. It further explores applications in tracking scaffold formation, assessing host cell-material interactions and tissue development, and probing the antitumor potential of engineered scaffolds. The review concludes with a perspective on IMC's role in advancing scaffold translation within the evolving regulatory landscape shaped by the FDA Modernization Acts 2.0 and 3.0.
{"title":"Isothermal microcalorimetry for scaffold design and characterization: Assessing bacterial and host cell interactions and physicochemical stability","authors":"Carmen Alvarez-Lorenzo, Angel Concheiro","doi":"10.1016/j.cis.2025.103681","DOIUrl":"10.1016/j.cis.2025.103681","url":null,"abstract":"<div><div>Scaffolds used in regenerative medicine are increasingly expected to address personalization, bioactivity, and sustainability, underscoring the need for characterization methods that reliably predict safety and efficacy. Isothermal microcalorimetry (IMC) offers a highly sensitive, label-free, real-time measurement of heat flow from energy-generating or -consuming process at scaffold interfaces. By monitoring microbial activity, host cell metabolism, material stability, and responses to environmental or therapeutic factors, IMC provides physiologically relevant insight into scaffold performance over extended periods. Its non-destructive, low-preparation, and passive nature preserves samples for complementary analyses, making it a versatile yet underutilized tool in biomedical research. This review introduces IMC for scaffold design and characterization, emphasizing its capacity to evaluate vulnerability to biofilm formation and the effectiveness of anti-biofilm strategies. It further explores applications in tracking scaffold formation, assessing host cell-material interactions and tissue development, and probing the antitumor potential of engineered scaffolds. The review concludes with a perspective on IMC's role in advancing scaffold translation within the evolving regulatory landscape shaped by the FDA Modernization Acts 2.0 and 3.0.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103681"},"PeriodicalIF":19.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carbon dot (CD)-incorporated hybrid microgels are emerging as advanced materials in the field of nanotechnology owing to their excellent potential in biomedical, environmental remediation, sensing and bioimaging applications. This review explores the integration of CDs within the polymeric microgel matrices, highlighting how CDs impart exceptional optical and biocompatible properties to create highly versatile, responsive and multifunctional hybrid microgels. A wide range of chemical and natural precursors can be utilized for the synthesis of CDs, complemented by diverse methodologies for fabricating hybrid microgels, including both innovative and traditional synthesis techniques. Detailed discussions on various characterization methods, ranging from spectroscopic and microscopic analyses to dynamic light scattering and zeta potential measurements, provide a comprehensive framework for understanding the structure, functionality, and performance of these materials. Key applications, such as precision drug delivery, real-time bioimaging, and environmental remediation are explored, underscoring the potential of these smart materials in driving resilient, sustainable technological innovations. By providing a thorough overview of current advancements and challenges, this review is intended to provide insights to researchers to inspire further research and propel the development of next-generation hybrid systems for practical, real-world applications.
{"title":"Carbon dot-embedded hybrid microgels: A new frontier in functional soft materials","authors":"Neha Garg , Armaandeep Kaur , Savita Chaudhary , Abhijit Dan","doi":"10.1016/j.cis.2025.103680","DOIUrl":"10.1016/j.cis.2025.103680","url":null,"abstract":"<div><div>Carbon dot (CD)-incorporated hybrid microgels are emerging as advanced materials in the field of nanotechnology owing to their excellent potential in biomedical, environmental remediation, sensing and bioimaging applications. This review explores the integration of CDs within the polymeric microgel matrices, highlighting how CDs impart exceptional optical and biocompatible properties to create highly versatile, responsive and multifunctional hybrid microgels. A wide range of chemical and natural precursors can be utilized for the synthesis of CDs, complemented by diverse methodologies for fabricating hybrid microgels, including both innovative and traditional synthesis techniques. Detailed discussions on various characterization methods, ranging from spectroscopic and microscopic analyses to dynamic light scattering and zeta potential measurements, provide a comprehensive framework for understanding the structure, functionality, and performance of these materials. Key applications, such as precision drug delivery, real-time bioimaging, and environmental remediation are explored, underscoring the potential of these smart materials in driving resilient, sustainable technological innovations. By providing a thorough overview of current advancements and challenges, this review is intended to provide insights to researchers to inspire further research and propel the development of next-generation hybrid systems for practical, real-world applications.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103680"},"PeriodicalIF":19.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-25DOI: 10.1016/j.cis.2025.103679
Jiuzhou Zhao , Binghao Han , Linjie Yang , Lili Zhang , Hongxiang Jiang , Jie He
The liquid-liquid phase transformation during the solidification of an immiscible alloy provides a route for developing the in-situ particulate composite of high performances. Researches demonstrate that the repulsion of solidification interface to the minority phase droplet may cause the formation of a microstructure with the minority phase droplets/particles enriched on grain boundaries or even a macro-segregated microstructure. The interaction between a solidification interface and droplets has not been well considered up to now. Generally, the models for the interaction between a particle and solidification interface were used to predicate the interaction between a droplet and solidification interface. In fact, the droplet nearby solidification interface may behave much differently from a particle due to its fluidity. This work develops a model describing the interaction between an advancing solidification interface and its nearby droplets. The model is verified by comparing with the experimental results. The factors influencing the capture of droplets by solidification interface are discussed in details. The numerical results demonstrate that the Marangoni migration of droplets makes the capture of droplets harder compared with the capture of particles. With the increase of the relative viscosity of the droplet to the matrix melt, the capture the droplet becomes easy. The Marangoni migration velocity is negligible small for a droplet of very high viscosity. The capture of such a droplet by solidification interface is similar to the capture of a solid particle.
{"title":"Interaction between droplet and advancing solidification interface during solidification of immiscible alloys","authors":"Jiuzhou Zhao , Binghao Han , Linjie Yang , Lili Zhang , Hongxiang Jiang , Jie He","doi":"10.1016/j.cis.2025.103679","DOIUrl":"10.1016/j.cis.2025.103679","url":null,"abstract":"<div><div>The liquid-liquid phase transformation during the solidification of an immiscible alloy provides a route for developing the in-situ particulate composite of high performances. Researches demonstrate that the repulsion of solidification interface to the minority phase droplet may cause the formation of a microstructure with the minority phase droplets/particles enriched on grain boundaries or even a macro-segregated microstructure. The interaction between a solidification interface and droplets has not been well considered up to now. Generally, the models for the interaction between a particle and solidification interface were used to predicate the interaction between a droplet and solidification interface. In fact, the droplet nearby solidification interface may behave much differently from a particle due to its fluidity. This work develops a model describing the interaction between an advancing solidification interface and its nearby droplets. The model is verified by comparing with the experimental results. The factors influencing the capture of droplets by solidification interface are discussed in details. The numerical results demonstrate that the Marangoni migration of droplets makes the capture of droplets harder compared with the capture of particles. With the increase of the relative viscosity of the droplet to the matrix melt, the capture the droplet becomes easy. The Marangoni migration velocity is negligible small for a droplet of very high viscosity. The capture of such a droplet by solidification interface is similar to the capture of a solid particle.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103679"},"PeriodicalIF":19.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The rising global need for natural gas and the reduction of greenhouse gas emissions highlight the significance of innovative storage solutions like hydrate-based solidified gas technology. Gas hydrates offer great potential as an efficient and safe method for storing methane and carbon dioxide. However, it faces operational challenges, primarily due to foam formation during gas recovery, which adversely affects efficiency and increases operational costs. As the gas hydrates dissociate, they release significant volumes of gas into the surrounding water. Surfactants reduce the surface tension of this water, enabling the released gas to form stable bubbles encased in thin liquid films. This review highlights innovative approaches to developing foam-free promoters, specifically focusing on amino acids, biosurfactants, and nanoparticles that enhance hydrate formation while mitigating foaming issues. This review evaluates the mechanisms underlying these promoters' effectiveness, emphasizing their promotion power and foaming ability. Comparative analyses reveal that amino acids and biosurfactants enable rapid hydrate formation and effective gas storage under varied conditions, while nanoparticle systems provide structural stability and efficiency in complex environments. The performance of foam-free promoters is assessed under various conditions, including temperature, pressure, and salinity, revealing the importance of molecular mechanisms in promoting hydrate stability and efficiency. The potential of environmentally friendly materials, such as amino acids and biosurfactants, is emphasized, showcasing their effectiveness in reducing foam formation without compromising hydrate formation rates. Furthermore, their compatibility with renewable energy strategies aligns with global sustainability goals, making them pivotal for the commercial use of gas storage based on hydrates. The integration of advanced computational tools and systematic experimentation is advocated for optimizing promoter formulations, ultimately paving the way for the commercial viability of hydrate technologies. This synthesis of findings provides a comprehensive framework for future research and applications in the field of gas storage and recovery, underscoring the transformative potential of foam-free hydrate promoters in sustainable energy systems.
{"title":"Advances in solidified methane and carbon dioxide storage: The potential of amino acids, biosurfactants, and nanoparticles as foam-free gas hydrate promoters","authors":"Elaheh Sadeh , Azam Shadloo , Kiana Peyvandi , Abdolreza Farhadian","doi":"10.1016/j.cis.2025.103678","DOIUrl":"10.1016/j.cis.2025.103678","url":null,"abstract":"<div><div>The rising global need for natural gas and the reduction of greenhouse gas emissions highlight the significance of innovative storage solutions like hydrate-based solidified gas technology. Gas hydrates offer great potential as an efficient and safe method for storing methane and carbon dioxide. However, it faces operational challenges, primarily due to foam formation during gas recovery, which adversely affects efficiency and increases operational costs. As the gas hydrates dissociate, they release significant volumes of gas into the surrounding water. Surfactants reduce the surface tension of this water, enabling the released gas to form stable bubbles encased in thin liquid films. This review highlights innovative approaches to developing foam-free promoters, specifically focusing on amino acids, biosurfactants, and nanoparticles that enhance hydrate formation while mitigating foaming issues. This review evaluates the mechanisms underlying these promoters' effectiveness, emphasizing their promotion power and foaming ability. Comparative analyses reveal that amino acids and biosurfactants enable rapid hydrate formation and effective gas storage under varied conditions, while nanoparticle systems provide structural stability and efficiency in complex environments. The performance of foam-free promoters is assessed under various conditions, including temperature, pressure, and salinity, revealing the importance of molecular mechanisms in promoting hydrate stability and efficiency. The potential of environmentally friendly materials, such as amino acids and biosurfactants, is emphasized, showcasing their effectiveness in reducing foam formation without compromising hydrate formation rates. Furthermore, their compatibility with renewable energy strategies aligns with global sustainability goals, making them pivotal for the commercial use of gas storage based on hydrates. The integration of advanced computational tools and systematic experimentation is advocated for optimizing promoter formulations, ultimately paving the way for the commercial viability of hydrate technologies. This synthesis of findings provides a comprehensive framework for future research and applications in the field of gas storage and recovery, underscoring the transformative potential of foam-free hydrate promoters in sustainable energy systems.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103678"},"PeriodicalIF":19.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145217112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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