Pub Date : 2026-01-28DOI: 10.1016/j.colsurfb.2026.115482
Satish Kumar Vemuri , P. Pavan Kumar , Ravi Adusumalli , Uttam Kumar Neeredu , K. Murali Manohar , G.P.V. Subbaiah , A.V. Gurava Reddy , Lipi Pradhan , Rajkiran Reddy Banala , M. Indira Devi , Sudip Mukherjee
Osteoarthritis (OA) is the most common and progressive joint disorder, characterized by the slow breakdown of cartilage and the underlying bone. The leading cause of OA is age-related wear and tear of joint cartilage, often worsened by factors such as obesity, joint injuries, genetic predisposition, repetitive stress, and joint misalignment. Current medical interventions are limited in their ability to regenerate damaged tissues. While synovial fluid-derived mesenchymal stem cells (SF-MSCs) and their exosomes show distinct therapeutic promise, their combined efficacy remains largely unexplored. This study investigates their synergistic potential in a preclinical osteoarthritis model, which has been optimized for rapid deployment and field applicability in combat scenarios. A full-thickness cartilage defect model was established in Wistar rats (n = 30), divided into four groups: PBS control, SF-MSCs alone, exosomes alone, and a combination therapy group. Treatments were administered intra-articularly. The combination therapy resulted in an 85.3 % reduction in cartilage defect size and a 57.8 % increase in bone density by week 8. Histological analysis confirmed enhanced cartilage regeneration and extracellular matrix formation. qPCR data showed significant upregulation of osteogenic markers. This dual-platform, cell-free approach offers a minimally invasive and scalable therapy for combat-related joint injuries and osteoarthritis. Its combination of differentiation, paracrine signaling, and immunomodulatory mechanisms delivers superior regenerative efficacy.
{"title":"Synergistic regeneration of cartilage and bone using synovial fluid-derived MSCs and exosomes: A novel therapeutic strategy for osteoarthritis","authors":"Satish Kumar Vemuri , P. Pavan Kumar , Ravi Adusumalli , Uttam Kumar Neeredu , K. Murali Manohar , G.P.V. Subbaiah , A.V. Gurava Reddy , Lipi Pradhan , Rajkiran Reddy Banala , M. Indira Devi , Sudip Mukherjee","doi":"10.1016/j.colsurfb.2026.115482","DOIUrl":"10.1016/j.colsurfb.2026.115482","url":null,"abstract":"<div><div>Osteoarthritis (OA) is the most common and progressive joint disorder, characterized by the slow breakdown of cartilage and the underlying bone. The leading cause of OA is age-related wear and tear of joint cartilage, often worsened by factors such as obesity, joint injuries, genetic predisposition, repetitive stress, and joint misalignment. Current medical interventions are limited in their ability to regenerate damaged tissues. While synovial fluid-derived mesenchymal stem cells (SF-MSCs) and their exosomes show distinct therapeutic promise, their combined efficacy remains largely unexplored. This study investigates their synergistic potential in a preclinical osteoarthritis model, which has been optimized for rapid deployment and field applicability in combat scenarios. A full-thickness cartilage defect model was established in Wistar rats (n = 30), divided into four groups: PBS control, SF-MSCs alone, exosomes alone, and a combination therapy group. Treatments were administered intra-articularly. The combination therapy resulted in an 85.3 % reduction in cartilage defect size and a 57.8 % increase in bone density by week 8. Histological analysis confirmed enhanced cartilage regeneration and extracellular matrix formation. qPCR data showed significant upregulation of osteogenic markers. This dual-platform, cell-free approach offers a minimally invasive and scalable therapy for combat-related joint injuries and osteoarthritis. Its combination of differentiation, paracrine signaling, and immunomodulatory mechanisms delivers superior regenerative efficacy.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115482"},"PeriodicalIF":5.6,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biodegradable magnesium (Mg) and its alloys can degrade safely in vivo without toxicity to the human body. However, the major bottleneck inhibiting Mg-based implants’ clinical use is the high corrosion rate. The serious corrosion leads to loss of mechanical integrity prematurely and bad biocompatibility. To break the bottleneck, modification with anticorrosive and bioactive coating is an ideal strategy. Metal-organic frameworks (MOFs) show good anticorrosive performance and perform good biocompatibility with up-and-coming applications in biomedical area such as drug delivery system, biological imaging and antibacterial property. Although numerous reports have reviewed the preparation and application of magnesium-based implant coating, relatively few report the MOF membranes coating of magnesium-based implant. Herein, this review provides the strategies for controlling corrosion of magnesium-based implants. Meanwhile, fabrication of nanoscale MOF membranes (in-situ growth and secondary growth method) is also mentioned. The application of MOFs based materials in the fields of corrosion protection and biomedicine are introduced. This work aims to provide a theoretical basis for addressing the key challenges of corrosion protection and biofunctionalization of degradable metal implants by systematically analyzing the functional characteristics and engineering design principles of MOFs coatings on magnesium-based implants.
{"title":"Controllable construction and corrosion control of MOFs membranes based multifunctional coatings on medical magnesium surfaces: A review","authors":"Jiayu He, Yali Li, Xing Zhang, Aotian He, Chao Xiong, Luhong Sun, Xin Chen, Liang Liu, Yi Tu, Dong Zeng","doi":"10.1016/j.colsurfb.2026.115477","DOIUrl":"10.1016/j.colsurfb.2026.115477","url":null,"abstract":"<div><div>Biodegradable magnesium (Mg) and its alloys can degrade safely in vivo without toxicity to the human body. However, the major bottleneck inhibiting Mg-based implants’ clinical use is the high corrosion rate. The serious corrosion leads to loss of mechanical integrity prematurely and bad biocompatibility. To break the bottleneck, modification with anticorrosive and bioactive coating is an ideal strategy. Metal-organic frameworks (MOFs) show good anticorrosive performance and perform good biocompatibility with up-and-coming applications in biomedical area such as drug delivery system, biological imaging and antibacterial property. Although numerous reports have reviewed the preparation and application of magnesium-based implant coating, relatively few report the MOF membranes coating of magnesium-based implant. Herein, this review provides the strategies for controlling corrosion of magnesium-based implants. Meanwhile, fabrication of nanoscale MOF membranes (in-situ growth and secondary growth method) is also mentioned. The application of MOFs based materials in the fields of corrosion protection and biomedicine are introduced. This work aims to provide a theoretical basis for addressing the key challenges of corrosion protection and biofunctionalization of degradable metal implants by systematically analyzing the functional characteristics and engineering design principles of MOFs coatings on magnesium-based implants.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115477"},"PeriodicalIF":5.6,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Injectable bone cements are widely applied in orthopedic repair, yet their effectiveness is limited by inadequate immune modulation and antimicrobial activity. Here, we developed a multifunctional bone cement (TTKS) by modifying tricalcium phosphate (TP-TCP, TTK) with tea polyphenols (TP) through supramolecular co-assembly and blending it with tricalcium silicate (C₃S) at an 8:2 ratio. The incorporation of tea polyphenols imparted sustained-release capability, antimicrobial activity, immunomodulatory effects, and osteogenic potential. In vitro, TTKS exhibited good cytocompatibility with osteoblasts (MC3T3-E1) and macrophages (RAW264.7), enhanced osteoblast proliferation, migration, and mineralized matrix deposition, and upregulated osteogenic markers (ALP, BMP-2, RUNX-2, OPN). TTKS effectively inhibited methicillin-resistant Staphylococcus aureus (MRSA) colonization by inducing a reactive oxygen species (ROS) burst, leading to bacterial DNA damage. Moreover, TTKS facilitated M2 macrophage polarization and enhanced the secretion of anti-inflammatory cytokines TGF-β1 and IL-10. In a rat cranial defect model, comprehensive evaluation through micro-CT scanning, H&E staining, and Masson's trichrome staining revealed that TTKS significantly promoted bone regeneration and defect repair over a 6-week implantation period. These results demonstrate that TTKS integrates osteogenic, antimicrobial, and immunomodulatory functions, providing a promising platform for bone defect repair and orthopedic applications.
{"title":"Supramolecularly co-assembled composite bone cement prepared from tea polyphenol-modified tricalcium phosphate/tricalcium silicate with osteogenic, antibacterial, and immunomodulatory effects.","authors":"Jian He, Lingnan Lai, Yu Fu, Xiangyu Song, Lijia Wang, Xiangrui Xu, Kunpeng Zhang, Ping Wang, Liang Qiao","doi":"10.1016/j.colsurfb.2026.115483","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2026.115483","url":null,"abstract":"<p><p>Injectable bone cements are widely applied in orthopedic repair, yet their effectiveness is limited by inadequate immune modulation and antimicrobial activity. Here, we developed a multifunctional bone cement (TTKS) by modifying tricalcium phosphate (TP-TCP, TTK) with tea polyphenols (TP) through supramolecular co-assembly and blending it with tricalcium silicate (C₃S) at an 8:2 ratio. The incorporation of tea polyphenols imparted sustained-release capability, antimicrobial activity, immunomodulatory effects, and osteogenic potential. In vitro, TTKS exhibited good cytocompatibility with osteoblasts (MC3T3-E1) and macrophages (RAW264.7), enhanced osteoblast proliferation, migration, and mineralized matrix deposition, and upregulated osteogenic markers (ALP, BMP-2, RUNX-2, OPN). TTKS effectively inhibited methicillin-resistant Staphylococcus aureus (MRSA) colonization by inducing a reactive oxygen species (ROS) burst, leading to bacterial DNA damage. Moreover, TTKS facilitated M2 macrophage polarization and enhanced the secretion of anti-inflammatory cytokines TGF-β1 and IL-10. In a rat cranial defect model, comprehensive evaluation through micro-CT scanning, H&E staining, and Masson's trichrome staining revealed that TTKS significantly promoted bone regeneration and defect repair over a 6-week implantation period. These results demonstrate that TTKS integrates osteogenic, antimicrobial, and immunomodulatory functions, providing a promising platform for bone defect repair and orthopedic applications.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"115483"},"PeriodicalIF":5.6,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1016/j.colsurfb.2026.115475
Hao Gong , Zhengfeng Lu , Suming Wei , Yongjun Rui
Osteosarcoma (OS)-induced bone abnormalities present a considerable clinical challenge due to elevated chances of recurrence and compromised repair, which significantly jeopardize patient survival. Contemporary bioactive glasses (BGs), notwithstanding their osteogenic potential, exhibit restricted anticancer efficacy. Therefore, It is essential to enhance the tumor-killing efficacy of BGs for usage as a filler in tumor-induced bone defects. Here, a copper (Cu)-doped 13–93BG (13–93BG-Cu) was synthesized and subsequently combined with chitosan to form the 13–93BG-Cu system. The rapid release of Cu ions (Cu2 +) during the initial stages of this system enhances the killing of tumor cells by cuproptosis, as intracellular Cu2+ accumulation triggers the oxidative stress response within mitochondria, hence achieving anti-OS therapy. Subsequently, the sustained low-level release of Cu2+ and bioactive ions collaboratively influences the activation and function of macrophage and stem cells, promoting bone defect healing. This study introduces a dual-action BG that simultaneously neutralizes the acidic tumor microenvironment and promotes cuproptosis, effectively preventing recurrence while facilitating bone healing via Cu2+ gradient release.
{"title":"Copper-infused 13–93 bioactive glass inhibiting postoperative osteosarcoma recurrence and enhancing bone regeneration","authors":"Hao Gong , Zhengfeng Lu , Suming Wei , Yongjun Rui","doi":"10.1016/j.colsurfb.2026.115475","DOIUrl":"10.1016/j.colsurfb.2026.115475","url":null,"abstract":"<div><div>Osteosarcoma (OS)-induced bone abnormalities present a considerable clinical challenge due to elevated chances of recurrence and compromised repair, which significantly jeopardize patient survival. Contemporary bioactive glasses (BGs), notwithstanding their osteogenic potential, exhibit restricted anticancer efficacy. Therefore, It is essential to enhance the tumor-killing efficacy of BGs for usage as a filler in tumor-induced bone defects. Here, a copper (Cu)-doped 13–93BG (13–93BG-Cu) was synthesized and subsequently combined with chitosan to form the 13–93BG-Cu system. The rapid release of Cu ions (Cu<sup>2 +</sup>) during the initial stages of this system enhances the killing of tumor cells by cuproptosis, as intracellular Cu<sup>2+</sup> accumulation triggers the oxidative stress response within mitochondria, hence achieving anti-OS therapy. Subsequently, the sustained low-level release of Cu<sup>2+</sup> and bioactive ions collaboratively influences the activation and function of macrophage and stem cells, promoting bone defect healing. This study introduces a dual-action BG that simultaneously neutralizes the acidic tumor microenvironment and promotes cuproptosis, effectively preventing recurrence while facilitating bone healing via Cu<sup>2+</sup> gradient release.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115475"},"PeriodicalIF":5.6,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1016/j.colsurfb.2026.115479
Rui Wang , Yicheng Cheng , Hong Chen , Wenxi Shan , Youbei Qiao , Jiang Wu
The host immune response critically determines the regeneration efficacy of peri-implant tissues. Exosomes derived from stem cells from human exfoliated deciduous teeth (SHED-Exo), enriched with bioactive components, demonstrate proven immunomodulatory capabilities. This study developed a composite structured coating system for loading and sustained-release delivery of SHED-Exo on titanium implants. The system integrates chitosan nanoparticles (CS-NPs) encapsulating SHED-Exo (CS@Exo NPs) within a Polylactic acid/polymalic acid (PLA/PMLA) electrospun nanofibrous membrane. Key findings revealed that: (1) CS-NPs maintained structural integrity and bioactivity of encapsulated SHED-Exo, enabling effective cellular internalization; (2) The composite coating comprising nanofibers and nanoparticles (PLA/PMLA/CS@Exo) demonstrated superior sustained-release performance, achieving continuous exosome delivery for over 30 days; (3) Released exosomes significantly promoted macrophage M2 polarization and anti-inflammatory cytokine secretion in vitro; (4) The nanofibrous coating exhibited excellent mechanical stability during simulated implantation and degradation characteristics. This dual nanoarchitecture establishes a robust platform for implant-surface functionalization, combining immunomodulation through bioactive exosome delivery with favorable degradation profiles.
{"title":"SHED-exosome-functionalized degradable fibrous coatings: Immunomodulatory engineering of titanium implant interfaces","authors":"Rui Wang , Yicheng Cheng , Hong Chen , Wenxi Shan , Youbei Qiao , Jiang Wu","doi":"10.1016/j.colsurfb.2026.115479","DOIUrl":"10.1016/j.colsurfb.2026.115479","url":null,"abstract":"<div><div>The host immune response critically determines the regeneration efficacy of peri-implant tissues. Exosomes derived from stem cells from human exfoliated deciduous teeth (SHED-Exo), enriched with bioactive components, demonstrate proven immunomodulatory capabilities. This study developed a composite structured coating system for loading and sustained-release delivery of SHED-Exo on titanium implants. The system integrates chitosan nanoparticles (CS-NPs) encapsulating SHED-Exo (CS@Exo NPs) within a Polylactic acid/polymalic acid (PLA/PMLA) electrospun nanofibrous membrane. Key findings revealed that: (1) CS-NPs maintained structural integrity and bioactivity of encapsulated SHED-Exo, enabling effective cellular internalization; (2) The composite coating comprising nanofibers and nanoparticles (PLA/PMLA/CS@Exo) demonstrated superior sustained-release performance, achieving continuous exosome delivery for over 30 days; (3) Released exosomes significantly promoted macrophage M2 polarization and anti-inflammatory cytokine secretion in vitro; (4) The nanofibrous coating exhibited excellent mechanical stability during simulated implantation and degradation characteristics. This dual nanoarchitecture establishes a robust platform for implant-surface functionalization, combining immunomodulation through bioactive exosome delivery with favorable degradation profiles.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115479"},"PeriodicalIF":5.6,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1016/j.colsurfb.2026.115481
Zixin Kang , Kehan Du , Zhuo-Ran Yang , Shunlan Luo , Xiaoping Zeng , Dawei Wang , Hongyang Zhao , Xiaowen Ou , Qianqian Liu , Hao Jiang , Jiangyu Wu
Ultraviolet radiation induces skin carcinogenesis through DNA damage and oxidative stress, driving demand for high-efficacy sunscreens. Current organic filters (e.g., octyl methoxycinnamate, OMC) suffer from narrow spectral coverage and phototoxicity. To address these limitations, we engineered OMC-loaded hollow mesoporous silica nanoparticles with polydopamine coating (OMC@HMSN@PDA). This nanoplatform achieved: (i) synergistic broad-spectrum protection, the sun protection factor (SPF) and UVA protection factor (UVAPF) up to 54 ± 0.74, 26.8 ± 6 with the concentration of 6 wt% OMC respectively, exceeding OMC@HMSN by 10.4-fold in UVB and 11.2-fold in UVA attenuation; (ii) 93.1 ± 1.2 % of DPPH and 98.5 ± 2.5 % of ABTS radical scavenging at 10 µg mL−1, and 94.6 ± 0.03 % intracellular reactive oxygen species (ROS) suppression; and (iii) prevention of the payload leakage and photo-instability of OMC, resolution of OMC’s phototoxicity with above 80 % cell viability in vitro. In vivo studies demonstrated prevention of UV-induced epidermal hyperplasia and lower inflammation. This technology establishes a promising approach for photoprotection integrating UV filtering, antioxidant activity, and enhanced safety.
{"title":"Polydopamine-sealed mesoporous silica nanocarriers loaded with organic UV filters for effective full-spectrum UV protection","authors":"Zixin Kang , Kehan Du , Zhuo-Ran Yang , Shunlan Luo , Xiaoping Zeng , Dawei Wang , Hongyang Zhao , Xiaowen Ou , Qianqian Liu , Hao Jiang , Jiangyu Wu","doi":"10.1016/j.colsurfb.2026.115481","DOIUrl":"10.1016/j.colsurfb.2026.115481","url":null,"abstract":"<div><div>Ultraviolet radiation induces skin carcinogenesis through DNA damage and oxidative stress, driving demand for high-efficacy sunscreens. Current organic filters (e.g., octyl methoxycinnamate, OMC) suffer from narrow spectral coverage and phototoxicity. To address these limitations, we engineered OMC-loaded hollow mesoporous silica nanoparticles with polydopamine coating (OMC@HMSN@PDA). This nanoplatform achieved: (i) synergistic broad-spectrum protection, the sun protection factor (SPF) and UVA protection factor (UVAPF) up to 54 ± 0.74, 26.8 ± 6 with the concentration of 6 wt% OMC respectively, exceeding OMC@HMSN by 10.4-fold in UVB and 11.2-fold in UVA attenuation; (ii) 93.1 ± 1.2 % of DPPH and 98.5 ± 2.5 % of ABTS radical scavenging at 10 µg mL<sup>−1</sup>, and 94.6 ± 0.03 % intracellular reactive oxygen species (ROS) suppression; and (iii) prevention of the payload leakage and photo-instability of OMC, resolution of OMC’s phototoxicity with above 80 % cell viability <em>in vitro</em>. <em>In vivo</em> studies demonstrated prevention of UV-induced epidermal hyperplasia and lower inflammation. This technology establishes a promising approach for photoprotection integrating UV filtering, antioxidant activity, and enhanced safety.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115481"},"PeriodicalIF":5.6,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1016/j.colsurfb.2026.115478
Yong Su , Nini Wang , Jiaqi Li, Ying Han, Haiming Fan, Yuan He
The increasing challenge of antimicrobial resistance necessitates the development of innovative treatment strategies. This review comprehensively examines the recent advancements in nanomaterial-based antibacterial platforms, focusing on their diverse mechanisms of action, including chemodynamic therapy, nanozyme therapy, photodynamic therapy, sonodynamic therapy, photothermal therapy, magnetothermal therapy, ion interference therapy, and gas therapy. Furthermore, the integration of multimodal therapies as well as strategies to integrate diagnostic-therapeutic functionalities is highlighted as a promising avenue for enhanced antibacterial treatment. Next, the rational design approaches employed to enhance the performance of nanomaterials, such as elemental doping, morphology control, and surface functionalization, are discussed. Despite significant progress, critical challenges remain in the areas of targeting precision, therapeutic efficiency under complex physiological conditions, biosafety, and clinical translation. This work provides valuable insights and forward-looking perspectives to guide the development of next-generation nano-antibacterial agents with enhanced functionality.
{"title":"Nanomaterial-based antibacterial strategies: Mechanisms, rational design, and future perspectives","authors":"Yong Su , Nini Wang , Jiaqi Li, Ying Han, Haiming Fan, Yuan He","doi":"10.1016/j.colsurfb.2026.115478","DOIUrl":"10.1016/j.colsurfb.2026.115478","url":null,"abstract":"<div><div>The increasing challenge of antimicrobial resistance necessitates the development of innovative treatment strategies. This review comprehensively examines the recent advancements in nanomaterial-based antibacterial platforms, focusing on their diverse mechanisms of action, including chemodynamic therapy, nanozyme therapy, photodynamic therapy, sonodynamic therapy, photothermal therapy, magnetothermal therapy, ion interference therapy, and gas therapy. Furthermore, the integration of multimodal therapies as well as strategies to integrate diagnostic-therapeutic functionalities is highlighted as a promising avenue for enhanced antibacterial treatment. Next, the rational design approaches employed to enhance the performance of nanomaterials, such as elemental doping, morphology control, and surface functionalization, are discussed. Despite significant progress, critical challenges remain in the areas of targeting precision, therapeutic efficiency under complex physiological conditions, biosafety, and clinical translation. This work provides valuable insights and forward-looking perspectives to guide the development of next-generation nano-antibacterial agents with enhanced functionality.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115478"},"PeriodicalIF":5.6,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1016/j.colsurfb.2026.115471
Amin Afzal, Mohammad Reza Farahpour, Zohreh Ghazi Tabatabaei
Infected wounds remain a major clinical challenge due to persistent inflammation, microbial colonization, and increasing antibiotic resistance. Here, we developed an injectable hyaluronic acid (HA)-tannic acid (TA) hydrogel incorporating berberine-loaded nanoliposomes (BRB-NLPs) as a multifunctional therapeutic platform. The hydrogel was prepared via PEGDE-mediated crosslinking and subsequent TA functionalization, followed by uniform embedding of BRB-NLPs. Physicochemical analyses confirmed successful crosslinking, thermal stability, tunable swelling, and a porous morphology suitable for drug loading. The system achieved high berberine encapsulation efficiency (87 %) and sustained release while maintaining nanoparticle stability. In vitro studies demonstrated strong antibacterial activity and excellent cytocompatibility. In a murine excision-infected wound model, HA/TA/BRB-NLPs significantly accelerated wound closure, promoted re-epithelialization and collagen deposition, and reduced bacterial burden. Molecular assays further revealed downregulation of pro-inflammatory mediators (IL-1β, TNF-α, TIMP-1/2, MMP-9) alongside upregulation of regenerative and anti-inflammatory markers (TGF-β, IL-10, COL1A1). Collectively, these findings highlight HA/TA/BRB-NLP hydrogels as a promising antibiotic-free biointerface material with synergistic antibacterial, anti-inflammatory, and regenerative effects for the management of infected wounds.
{"title":"Hyaluronic acid-tannic acid hydrogel incorporating berberine nanoliposomes enhances infected wound healing.","authors":"Amin Afzal, Mohammad Reza Farahpour, Zohreh Ghazi Tabatabaei","doi":"10.1016/j.colsurfb.2026.115471","DOIUrl":"https://doi.org/10.1016/j.colsurfb.2026.115471","url":null,"abstract":"<p><p>Infected wounds remain a major clinical challenge due to persistent inflammation, microbial colonization, and increasing antibiotic resistance. Here, we developed an injectable hyaluronic acid (HA)-tannic acid (TA) hydrogel incorporating berberine-loaded nanoliposomes (BRB-NLPs) as a multifunctional therapeutic platform. The hydrogel was prepared via PEGDE-mediated crosslinking and subsequent TA functionalization, followed by uniform embedding of BRB-NLPs. Physicochemical analyses confirmed successful crosslinking, thermal stability, tunable swelling, and a porous morphology suitable for drug loading. The system achieved high berberine encapsulation efficiency (87 %) and sustained release while maintaining nanoparticle stability. In vitro studies demonstrated strong antibacterial activity and excellent cytocompatibility. In a murine excision-infected wound model, HA/TA/BRB-NLPs significantly accelerated wound closure, promoted re-epithelialization and collagen deposition, and reduced bacterial burden. Molecular assays further revealed downregulation of pro-inflammatory mediators (IL-1β, TNF-α, TIMP-1/2, MMP-9) alongside upregulation of regenerative and anti-inflammatory markers (TGF-β, IL-10, COL1A1). Collectively, these findings highlight HA/TA/BRB-NLP hydrogels as a promising antibiotic-free biointerface material with synergistic antibacterial, anti-inflammatory, and regenerative effects for the management of infected wounds.</p>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"115471"},"PeriodicalIF":5.6,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-27DOI: 10.1016/j.colsurfb.2026.115480
Suraj Kumar , Saurabh Srivastava , Ching Siang Tan , Mohammed Abohashrh , Rishabha Malviya
Biological proteins play a crucial role at the intersection of oral health and neuroscience, offering promising opportunities for improved diagnosis, prevention, and treatment. This review highlights the molecular, inflammatory, and biochemical pathways linking oral diseases, particularly periodontal disease and microbial dysbiosis, with neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Key inflammatory, neuroprotective, and tissue-repair proteins play a crucial role in maintaining both oral integrity and neural function. Advances in proteomics and molecular imaging have clarified how protein misfolding, aggregation, and immune responses drive neuroinflammation and cognitive decline. Emerging therapies include protein-based biomaterials, such as hydrogels, nanocarriers, and protein–polymer hybrids, for delivering neuroprotective and regenerative agents through oral and nasal routes. Early diagnosis is being transformed by salivary proteomics and transcriptomics, enabling non-invasive detection of neurodegenerative biomarkers. Host-defense peptides and antimicrobial proteins also show promise in controlling oral infections that may exacerbate brain inflammation. Integrating oral biology, biomaterials science, and neuroscience is accelerating clinical translation through the development of innovative scaffolds and smart delivery systems. Despite challenges in biomarker validation and clinical application, advances in artificial intelligence, bioinformatics, and protein engineering are driving the future of personalized regenerative and preventive medicine. Overall, biological proteins provide a critical molecular link between oral and neural health, paving the way for novel non-invasive diagnostic and therapeutic strategies.
{"title":"Correlation between oral disease and neurodegenerative disorders: Role of biological proteins for the modulation of oral-brain axis and gut-brain axis","authors":"Suraj Kumar , Saurabh Srivastava , Ching Siang Tan , Mohammed Abohashrh , Rishabha Malviya","doi":"10.1016/j.colsurfb.2026.115480","DOIUrl":"10.1016/j.colsurfb.2026.115480","url":null,"abstract":"<div><div>Biological proteins play a crucial role at the intersection of oral health and neuroscience, offering promising opportunities for improved diagnosis, prevention, and treatment. This review highlights the molecular, inflammatory, and biochemical pathways linking oral diseases, particularly periodontal disease and microbial dysbiosis, with neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Key inflammatory, neuroprotective, and tissue-repair proteins play a crucial role in maintaining both oral integrity and neural function. Advances in proteomics and molecular imaging have clarified how protein misfolding, aggregation, and immune responses drive neuroinflammation and cognitive decline. Emerging therapies include protein-based biomaterials, such as hydrogels, nanocarriers, and protein–polymer hybrids, for delivering neuroprotective and regenerative agents through oral and nasal routes. Early diagnosis is being transformed by salivary proteomics and transcriptomics, enabling non-invasive detection of neurodegenerative biomarkers. Host-defense peptides and antimicrobial proteins also show promise in controlling oral infections that may exacerbate brain inflammation. Integrating oral biology, biomaterials science, and neuroscience is accelerating clinical translation through the development of innovative scaffolds and smart delivery systems. Despite challenges in biomarker validation and clinical application, advances in artificial intelligence, bioinformatics, and protein engineering are driving the future of personalized regenerative and preventive medicine. Overall, biological proteins provide a critical molecular link between oral and neural health, paving the way for novel non-invasive diagnostic and therapeutic strategies.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115480"},"PeriodicalIF":5.6,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-26DOI: 10.1016/j.colsurfb.2026.115474
Yang Liu , Yuan Liu , Chang Xu , Fangming Jiang , Xiaorong Yang
Tumor suppressor p53 formed the droplets with the solidification tendency. Mutations in p53 could accelerate the aggregation of droplets, resulting in p53 to lose the function and/or to gain the oncogenic activity. In this study, the effects of CP-31398 on the phase behaviors of p53 mutants were explored. The results revealed that CP-31398 could inhibit the pathological aggregation of R175H p53, restored the interaction between R175H p53 and specific DNA, and promoted the formation of functional droplets. For R248W p53, CP-31398 could regulate the phase behavior but not restore the formation of functional condensates. Molecular dynamics simulations showed that CP-31398 enhanced the structural stability of R175H p53 by stabilizing the zinc-binding domain and 251–258 segment. These findings provided new insights into the molecular basis that CP-31398 restored the liquid-liquid phase separation of p53 mutant, and could offer the novel therapeutic strategy for cancers with p53 mutant.
{"title":"CP-31398 restored the functional condensates of R175H p53 by stabilizing the zinc-binding domain and 251–258 segment","authors":"Yang Liu , Yuan Liu , Chang Xu , Fangming Jiang , Xiaorong Yang","doi":"10.1016/j.colsurfb.2026.115474","DOIUrl":"10.1016/j.colsurfb.2026.115474","url":null,"abstract":"<div><div>Tumor suppressor p53 formed the droplets with the solidification tendency. Mutations in p53 could accelerate the aggregation of droplets, resulting in p53 to lose the function and/or to gain the oncogenic activity. In this study, the effects of CP-31398 on the phase behaviors of p53 mutants were explored. The results revealed that CP-31398 could inhibit the pathological aggregation of R175H p53, restored the interaction between R175H p53 and specific DNA, and promoted the formation of functional droplets. For R248W p53, CP-31398 could regulate the phase behavior but not restore the formation of functional condensates. Molecular dynamics simulations showed that CP-31398 enhanced the structural stability of R175H p53 by stabilizing the zinc-binding domain and 251–258 segment. These findings provided new insights into the molecular basis that CP-31398 restored the liquid-liquid phase separation of p53 mutant, and could offer the novel therapeutic strategy for cancers with p53 mutant.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"262 ","pages":"Article 115474"},"PeriodicalIF":5.6,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146048913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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