Colloids and Surfaces B: Biointerfaces最新文献_第9页

Enhancing properties of damaged hair through moisture control via construction of highly hydrophobic surface 通过高度疏水表面的结构来控制水分，增强受损头发的性能

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces

Pub Date : 2026-01-06 DOI: 10.1016/j.colsurfb.2026.115427

Fubing Liu , Chaohai Li , Jinhua Li , Jing Wang , Kuan Chang

Hair dyeing and perming processes damage could significantly reduce the stability and mechanical properties of keratin, making hair rough and fragile. Different hair repair ingredients have been developed by strengthening the chemical bonds inside hair. In this work, a new repair strategy of altering hair water content by construing highly hydrophobic surface was proposed. This was achieved by treating damaged hair with maleic-modified amino silicone oil (MASO), which was synthesized through the amidation reaction of maleic acid with poly[dimethylsiloxane-co-(3-aminopropyl)methylsiloxane] (ASO). Due to the thiol-Michael click reaction with free thiol groups on reduced hair surface, MASO presented high deposition efficiency at a low dosage of 0.1 wt%, which was confirmed by SEM and contact angle measurements. After MASO treatment, hair forms a highly hydrophobic surface with a contact angle of 137 °, significantly higher than that of virgin hair. The highly hydrophobic surface hinders the penetration of moisture into the hair, especially reducing the bound water content from 4.46 % to 2.81 %. This was jointly proven by the disappearance process of water droplets on hair strands, TGA testing, and DVS testing. The reduced water content in MASO-treated hair significantly lowered the combing work, with the wet combing work decreasing from 336.12 J to 43.52 J, giving a 87.05 % decrease, and enhanced the thermal stability of keratin, ultimately increasing Young's modulus and tensile strength by 13.99 % and 9.13 %, respectively. This finding demonstrates that the impact of water on tensile properties can even exceed the adverse effects caused by the breakage of disulfide bonds for reduce damaged hair.

染发和烫发过程的损伤会显著降低角蛋白的稳定性和力学性能，使头发变得粗糙和脆弱。通过加强头发内部的化学键，已经开发出了不同的护发成分。本文提出了一种通过构建高疏水表面来改变头发含水量的修复策略。这是通过马来酸与聚[二甲基硅氧烷-co-（3-氨基丙基）甲基硅氧烷]（ASO）酰胺化反应合成的马来烯改性氨基硅氧油（MASO）治疗受损头发而实现的。通过扫描电镜和接触角测量证实，在0.1 wt%的低剂量下，MASO与还原毛表面的游离巯基发生了巯基-迈克尔键合反应，具有较高的沉积效率。经过MASO处理后，头发形成高度疏水表面，接触角为137 °，明显高于未处理头发。高度疏水的表面阻碍了水分渗透到头发中，特别是将结合水含量从4.46 %降低到2.81 %。水滴在发丝上的消失过程、TGA测试和DVS测试共同证明了这一点。经maso处理的头发含水量降低，显著降低了精梳功，湿法精梳功从336.12 J减少到43.52 J，减少87.05 %，增强了角蛋白的热稳定性，最终杨氏模量和抗拉强度分别提高13.99 %和9.13 %。这一发现表明，水对拉伸性能的影响甚至可以超过二硫键断裂所造成的不利影响，以减少受损的头发。

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引用次数: 0

Fabrication of SilMA hydrogels with stiffness gradients for soft-to-hard interface tissue engineering 软硬界面组织工程中具有刚度梯度的SilMA水凝胶的制备。

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces

Pub Date : 2026-01-06 DOI: 10.1016/j.colsurfb.2026.115425

Siyuan Liu , Xialing Tu , Jiaxuan Huang , Nianjie Wu , Bin Xia , Guobao Chen

Native tissue interfaces exhibit continuous gradients in mechanical stiffness and extracellular matrix (ECM) composition, which are essential for effective load transmission and functional integration between adjacent tissues. However, accurately replicating these intricate biomechanical gradients in engineered biomaterials remains a significant challenge in interface tissue engineering. In this study, we present a stiffness-gradient methacrylated silk fibroin (SilMA) hydrogel designed to promote tissue interface regeneration, with a focus on mechanical cues as a critical design parameter. Silk fibroin was chemically modified into SilMA, and its concentration systematically varied to produce multilayer hydrogels exhibiting a continuous stiffness gradient ranging from 7.07 ± 4.02 kPa to 71.30 ± 0.97 kPa, effectively mimicking the native mechanical heterogeneity found at tissue interfaces. Functional assays revealed that the low-stiffness layer significantly enhanced angiogenesis, the intermediate-stiffness layer provided an optimal mechanical environment for stem cell osteogenic differentiation, and the high-stiffness layer recapitulated the biomechanical properties of native cartilage tissue. This biomimetic stiffness-gradient SilMA hydrogel scaffold offers a promising strategy for regenerating complex tissue interfaces by harnessing the instructive role of mechanical microenvironments. Our findings underscore the importance of spatially graded mechanical properties in guiding cellular responses and tissue repair, and advance the design of next-generation materials for interface tissue engineering.

原生组织界面在机械刚度和细胞外基质（ECM）组成上表现出连续的梯度，这对于相邻组织之间有效的载荷传递和功能整合至关重要。然而，在工程生物材料中精确地复制这些复杂的生物力学梯度仍然是界面组织工程的一个重大挑战。在这项研究中，我们提出了一种刚度梯度甲基丙烯酸基丝素（SilMA）水凝胶，旨在促进组织界面再生，重点关注机械线索作为关键设计参数。将丝素蛋白化学修饰为SilMA，并系统地改变其浓度，制备出具有连续刚度梯度的多层水凝胶，其范围从7.07 ±4.02 kPa到71.30 ±0.97 kPa，有效地模拟了组织界面的天然力学非均质性。功能分析显示，低刚度层显著促进血管生成，中等刚度层为干细胞成骨分化提供了最佳的力学环境，高刚度层再现了天然软骨组织的生物力学特性。这种仿生刚度梯度SilMA水凝胶支架通过利用机械微环境的指导作用，为复杂组织界面的再生提供了一种有前途的策略。我们的发现强调了空间梯度力学性能在指导细胞反应和组织修复中的重要性，并推进了下一代界面组织工程材料的设计。

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引用次数: 0

Osteoinductive sandwich-structured HA/PEEK implant for rapid critical-size skull repair 骨诱导夹层结构HA/PEEK植入物用于快速修复临界尺寸颅骨

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces

Pub Date : 2026-01-06 DOI: 10.1016/j.colsurfb.2026.115428

Mei-li Qi , Kunshan Yuan , Enhui Song , Xiangyi Feng , Tianheng Lu , Lin Zhao , Haihong Guo , Haijun Zhang

Critical-size bone defects afflict millions annually, driving a cascade of inflammation and incomplete tissue regeneration. Polyetheretherketone (PEEK) remains the material of choice for load-bearing implants because its modulus mirrors that of cortical bone; yet its notorious bioinertness curtails both anti-inflammatory signaling and osseointegration, stalling the healing process. To break this stalemate, we designed a sandwich-structured, osteoinductive hydroxyapatite (HA)/PEEK implant tailored for skull repair. A porous PEEK core was engineered via the salting out technique and its surface was homogeneously functionalized with HA through simple physical blending, preserving the implant’s open porosity while imparting potent osteoinductive activity. In a rabbit critical calvarial defect (10 mm diameter), new bone advanced from the periphery to the center, achieving full osseous continuity within only 4 months and markedly surpassing unmodified PEEK. The robust bone-implant integration demonstrated by this sandwich HA/PEEK construct not only converts a bioinert polymer into an osteoinductive implant but also may expand treatment options for growing children, offering a clinically translatable solution for skull repair after trauma, hemorrhage, tumor resection, or congenital dysplasia.

严重的骨缺损每年折磨数百万人，引发一连串的炎症和不完全的组织再生。聚醚醚酮（PEEK）仍然是承重植入物的首选材料，因为它的模量与皮质骨相似；然而，其臭名昭著的生物惰性限制了抗炎信号和骨整合，延缓了愈合过程。为了打破这一僵局，我们设计了一种三明治结构的骨诱导羟基磷灰石(HA)/PEEK植入物，专门用于颅骨修复。通过盐析技术设计多孔PEEK芯，其表面通过简单的物理混合与透明质酸均匀功能化，保留了植入物的开放孔隙度，同时赋予了有效的骨诱导活性。在兔严重颅骨缺损（10 mm直径）中，新骨从周围向中心推进，仅在4个月内实现了完全的骨连续性，明显优于未修饰的PEEK。这种夹层HA/PEEK结构所展示的强大的骨植入整合不仅将生物惰性聚合物转化为骨诱导植入物，而且还可以为成长中的儿童提供更多的治疗选择，为创伤、出血、肿瘤切除或先天性发育不良后的颅骨修复提供临床可翻译的解决方案。

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引用次数: 0

ZIF-8-based Schottky heterojunction for boosting the sonodynamic antimicrobial effect of chlorin e6 on MRSA 基于zif -8的肖特基异质结增强氯e6对MRSA的声动力抗菌作用

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces

Pub Date : 2026-01-06 DOI: 10.1016/j.colsurfb.2026.115419

Xiaoyang Xu , Danni Wang , Bingjie Leng , Tingting Gao , Zhenning Cui , Xiao Wang , Bin Liu

Sonodynamic antimicrobial chemotherapy (SACT) has been regarded as an emerging approach for antimicrobial treatment due to its advantages of deep tissue penetration, non-invasive nature, and absence of resistance. However, several challenges hinder its clinical application, for example insufficient oxygen levels at infection sites, poor solubility and stability of sonosensitizers. Herein, we developed chlorin e6@ZIF-8@Ag (CZ@Ag) nanocomposite as a Schottky heterojunction sonosensitizer with high electron-hole separation and narrow bandgap. The results reveal that the Schottky barrier between ZIF-8 and Ag nanoparticles can availably restrain electron backflow, further promoting the yield of reactive oxygen species (ROS) under ultrasound treatment. Experimentally, the minimum inhibitory concentration of CZ@Ag against methicillin-resistant Staphylococcus aureus (MRSA) reduced from 320 μg/mL to 80 μg/mL, and its antibacterial rate was up to 96.3 % after 3 min of ultrasound irradiation. Furthermore, mechanistic studies found that CZ@Ag-mediated SACT is mainly achieved by inhibiting biofilm formation, damaging cell membrane integrity, enhancing more ROS generation, and increasing cell membrane permeability, leading to the leakage of intracellular contents. All these findings proved that CZ@Ag had great possibility for antibacterial therapy, and this investigation offered a feasible direction for developing efficient sonosensitizers.

声动力抗菌素化疗（SACT）因其深入组织、无创、无耐药等优点而被认为是一种新兴的抗菌素治疗方法。然而，一些挑战阻碍了其临床应用，例如感染部位的氧气水平不足，超声增敏剂的溶解度和稳定性差。在此，我们开发了氯e6@ZIF-8@Ag （CZ@Ag）纳米复合材料作为具有高电子空穴分离和窄带隙的肖特基异质结声敏剂。结果表明，ZIF-8与Ag纳米粒子之间的Schottky势垒可以有效地抑制电子回流，进一步促进超声处理下活性氧（ROS）的产率。实验结果表明，CZ@Ag对耐甲氧西林金黄色葡萄球菌（MRSA）的最低抑菌浓度由320 μg/mL降至80 μg/mL，超声照射3 min后其抑菌率高达96.3% %。此外，机制研究发现CZ@Ag-mediated SACT主要通过抑制生物膜的形成，破坏细胞膜的完整性，增加ROS的产生，增加细胞膜的通透性，导致细胞内内容物的渗漏来实现。这些发现证明CZ@Ag具有很大的抗菌治疗可能性，为开发高效的声敏剂提供了可行的方向。

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引用次数: 0

Synergistic eradication of drug-resistant bacteria by rhamnolipids and pyocyanin via combined membrane permeabilization and oxidative stress 鼠李糖脂和花青素联合膜渗透和氧化应激协同消灭耐药细菌

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces

Pub Date : 2026-01-06 DOI: 10.1016/j.colsurfb.2026.115418

Li Luo , Deyu Zhang , Mengqian Zhao , Jing Chen , Jian Yin , Xuwei Long

The threat of antimicrobial resistance (AMR) necessitates novel approaches against multidrug-resistant pathogens. This study pioneers a synergistic antibacterial strategy using rhamnolipids (RLs), a membrane-disrupting biosurfactant, and pyocyanin (Pyo), a redox-active compound, both produced by Pseudomonas aeruginosa. Results demonstrate that RLs compromise bacterial membrane and biofilm integrity, enhancing Pyo penetration. Intracellular Pyo then induces lethal oxidative stress via ROS generation and respiration inhibition. The combination exhibits remarkable synergy (FICI ≤0.375), reducing the required Pyo concentration by 16–64-fold against resistant strains. This dual-agent system not only ensures effective antibacterial activity but also maintains low mammalian cell cytotoxicity. Through complementary, lower-risk mechanisms, the RLs/Pyo pair presents a promising platform for treating intractable infections.

抗菌素耐药性（AMR）的威胁需要针对多重耐药病原体的新方法。这项研究开创了一种协同抗菌策略，使用鼠李糖脂（RLs），一种破坏膜的生物表面活性剂，和花青素（Pyo），一种氧化还原活性化合物，两者都由铜绿假单胞菌产生。结果表明，RLs损害了细菌膜和生物膜的完整性，增强了Pyo的渗透。然后，胞内Pyo通过ROS生成和呼吸抑制诱导致死性氧化应激。该组合对耐药菌株具有显著的协同作用（FICI≤0.375），可将所需的Pyo浓度降低16 - 64倍。这种双药系统不仅保证了有效的抗菌活性，而且保持了较低的哺乳动物细胞毒性。通过互补、低风险的机制，RLs/Pyo组合为治疗难治性感染提供了一个有希望的平台。

引用次数: 0

Mechanically robust zwitterionic hydrogel coating reinforced by microgels for antibacterial and anticoagulant applications 机械坚固两性离子水凝胶涂层增强微凝胶抗菌和抗凝应用

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces

Pub Date : 2026-01-06 DOI: 10.1016/j.colsurfb.2026.115422

Haiyang Chai , Kai Cheng , Jiru Miao , Longxing Niu , Xiao Cen , Ying Xiao , Feiyu Chen , Rong Wang

Nosocomial infections and thrombosis associated with implantable medical devices have emerged as increasingly critical clinical challenges. Antifouling hydrogels, owing to their biocompatibility and highly hydrophilic surfaces, have garnered significant attention as a promising strategy to mitigate these complications. However, conventional hydrogels often suffer from poor mechanical strength due to their high-water content and the absence of efficient energy dissipation mechanisms, leading to weak adhesion to underlying substrates and potential detachment under physiological conditions. In this study, vinyl-functionalized poly(N-isopropylacrylamide-co-acrylic acid) microgels were incorporated into polysulfobetaine hydrogel networks to overcome these limitations. The microgels enhanced the crosslinking density to improve the mechanical strength of the hydrogels, acted as sacrificial bonds for energy dissipation, and functioned as carriers for antibacterial agents. The polysulfobetaine hydrogel coating effectively reduced the friction coefficient and significantly improved antibacterial and anti-platelet adhesion performance. Moreover, antimicrobial-loaded microgels imparted the hydrogel coating with enhanced antibacterial functionality. The in vivo anticoagulant performance of the hydrogel-coated catheter was validated through implantation into the external jugular vein of rabbits, confirming its therapeutic potential. This multifunctional hydrogel coating strategy presents a promising avenue for the development of mechanically robust, antibacterial, and anticoagulant surface modifications for implantable biomedical devices.

与植入式医疗器械相关的医院感染和血栓形成已成为日益严峻的临床挑战。防污水凝胶，由于其生物相容性和高度亲水性的表面，已经获得了显著的关注，作为一个有希望的策略，以减轻这些并发症。然而，传统的水凝胶由于含水量高，缺乏有效的能量耗散机制，往往存在机械强度较差的问题，导致其在生理条件下与底物的粘附能力较弱，可能发生脱落。在本研究中，乙烯基功能化聚（n -异丙基丙烯酰胺-共丙烯酸）微凝胶被纳入聚磺基甜菜碱水凝胶网络，以克服这些局限性。微凝胶增强交联密度，提高水凝胶的机械强度，作为牺牲键耗散能量，并作为抗菌剂的载体。聚磺胺甜菜碱水凝胶涂层有效降低了摩擦系数，显著提高了抗菌和抗血小板粘附性能。此外，负载抗菌剂的微凝胶赋予水凝胶涂层增强的抗菌功能。通过植入家兔颈外静脉，验证了水凝胶包覆导管的体内抗凝性能，证实了其治疗潜力。这种多功能水凝胶涂层策略为开发用于植入式生物医学设备的机械坚固、抗菌和抗凝表面改性提供了一条有前途的途径。

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引用次数: 0

Recent advances in hydrogel therapy for traumatic brain injury 水凝胶治疗外伤性脑损伤的最新进展。

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces

Pub Date : 2026-01-06 DOI: 10.1016/j.colsurfb.2026.115424

Zheng Zou , Mengjia Chen , Jun Liu , Huan Ma , Guobiao Liang , Jingyuan Li

Traumatic brain injury (TBI) remains one of the most devastating neurological disorders, characterized by complex primary mechanical damage and secondary cascades involving inflammation, oxidative stress, and glial scar formation. Conventional therapies offer limited efficacy due to the blood–brain barrier, the inability to reconstruct tissue defects, and poor spatiotemporal drug control. Hydrogels have emerged as a versatile platform for brain repair owing to their high-water content, biocompatibility, tunable mechanics, and injectability. By tailoring their composition and crosslinking mechanisms, hydrogels can mimic the native brain extracellular matrix, fill irregular cavities, and provide mechanical support that matches neural tissue softness. More importantly, functional hydrogels serve as local delivery vehicles for neuroprotective drugs and growth factors, scaffolds for stem cell transplantation, and active regulators of the post-injury microenvironment. Recent advances include bioactive, conductive, and stimuli-responsive hydrogels capable of modulating immune polarization, enhancing angiogenesis, and promoting neurogenesis. Despite encouraging preclinical results, challenges remain in achieving long-term biocompatibility, precise degradation control, and scalable clinical translation. This review summarizes the current progress, underlying mechanisms, and emerging design strategies of hydrogel-based therapies for TBI, highlighting their potential as next-generation biomaterials for neuroregeneration and functional recovery.

创伤性脑损伤（TBI）是最具破坏性的神经系统疾病之一，其特点是复杂的原发性机械损伤和继发性级联反应，包括炎症、氧化应激和神经胶质瘢痕形成。由于血脑屏障，无法重建组织缺陷，以及药物时空控制差，传统疗法的疗效有限。水凝胶由于其高含水量、生物相容性、可调力学和可注射性而成为脑修复的通用平台。通过调整它们的组成和交联机制，水凝胶可以模拟天然的大脑细胞外基质，填充不规则的空洞，并提供与神经组织柔软度相匹配的机械支持。更重要的是，功能水凝胶可以作为神经保护药物和生长因子的局部递送载体，干细胞移植的支架，以及损伤后微环境的主动调节剂。最近的进展包括生物活性、导电性和刺激反应性水凝胶，能够调节免疫极化、增强血管生成和促进神经发生。尽管临床前结果令人鼓舞，但在实现长期生物相容性、精确降解控制和可扩展的临床转化方面仍然存在挑战。本文综述了目前基于水凝胶治疗TBI的进展、潜在机制和新兴设计策略，强调了它们作为下一代神经再生和功能恢复生物材料的潜力。

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引用次数: 0

Organic nano-quantum dots of salvianolic acid B modified with photosensitive cypate for diagnosis and treatment of myocardial 光敏cypate修饰丹参酚酸B有机纳米量子点诊断和治疗心肌

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces

Pub Date : 2026-01-05 DOI: 10.1016/j.colsurfb.2026.115414

Na Wang , Ye Zhang , Wen Huang , Wei Du , Chunhua Ma , YuQiang Fang , Chunyu Zeng

Salvianolic acid B (SaB) demonstrates significant cardioprotective effects against myocardial ischemia–reperfusion injury (I/R). However, its clinical application is limited by rapid metabolism and poor bioavailability. To address this, we synthesized SaB-loaded organic quantum dots (SaB@qd) via a hydrothermal method and functionalized them with the near-infrared (NIR) dye cypate (SaB@qd@Cy). Proteomic analysis of cardiac tissues from I/R model rats identified SIRT2 as a key downregulated protein. Molecular docking and cell membrane chromatography confirmed SaB as a natural SIRT2 agonist, binding specifically to the SER-263 residue. SaB@qd@Cy enhanced myocardial SaB accumulation by 3.2-fold compared to free SaB (P < 0.01). In vivo, SaB@qd@Cy reduced the infarct area by 41 % (compared to 28 % reduction by mitochondrial-targeted CoQ10 nanoparticles) and attenuated inflammatory cytokine expression (IL-1β, TNF-α) via the SIRT2/NLRP3 pathway. Additionally, cypate enabled real-time NIR imaging of ischemic borders, with a temperature increase of 15.3 ± 1.2°C under 808 nm laser irradiation. This study presents a novel theranostic nanoplatform that integrates natural compounds with photoresponsive quantum dots for targeted therapy and intraoperative imaging in I/R management.

丹酚酸B （SaB）对心肌缺血再灌注损伤（I/R）具有显著的心脏保护作用。但其代谢快、生物利用度差，限制了其临床应用。为了解决这个问题，我们通过水热法合成了负载ab的有机量子点（SaB@qd），并用近红外（NIR）染料cypate （SaB@qd@Cy）对其进行了功能化。I/R模型大鼠心脏组织的蛋白质组学分析发现SIRT2是一个关键的下调蛋白。分子对接和细胞膜色谱证实SaB是一种天然的SIRT2激动剂，特异性结合SER-263残基。SaB@qd@Cy使心肌SaB积累增加3.2倍（P <； 0.01）。在体内，SaB@qd@Cy通过SIRT2/NLRP3途径减少了41 %的梗死面积（相比之下，线粒体靶向CoQ10纳米颗粒减少了28 %），并减弱了炎症细胞因子（IL-1β, TNF-α）的表达。此外，在808 nm激光照射下，cypate使缺血边界的实时近红外成像温度升高15.3 ± 1.2°C。本研究提出了一种新的治疗纳米平台，该平台将天然化合物与光响应量子点结合起来，用于I/R管理中的靶向治疗和术中成像。

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引用次数: 0

Rationally designed BTO@MSN@PPy-PEG piezoelectric nanozyme for ultrasound/NIR-triggered synergistic piezodynamic-photothermal-chemo tumor therapy 合理设计BTO@MSN@ py - peg压电纳米酶用于超声/ nir触发的压电-光热-化疗协同肿瘤治疗

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces

Pub Date : 2026-01-03 DOI: 10.1016/j.colsurfb.2025.115409

Yunxia Hu , Yangbei Zhu , Lijie Liu , Jiaxuan Guo , Wenjie Gao , Lei Tian , Shige Wang , Chengzheng Jia

Conventional monotherapies for tumors face significant challenges due to their limited therapeutic efficacy and considerable side effects, which severely impede their broad clinical application. To overcome the advancement of multimodal synergistic treatment strategies, integrating diverse treatment modalities with complementary mechanisms has emerged as a crucial approach to enhance the therapeutic outcomes of tumors. In this context, we developed a multifunctional nanoplatform, designated as BaTiO₃@MSN@PPy-PEG Nanoparticles (BMPP NPs), which can be activated by a combination of ultrasound and near-infrared (NIR) laser irradiation. This nanoplatform is centered around the piezoelectric material barium titanate (BTO), employs a mesoporous silica (MSN) coating for efficient encapsulation of the chemotherapeutic agent curcumin (Cur), and is further modified with polypyrrole (PPy) and polyethylene glycol (PEG) to confer both excellent photothermal conversion capability and enhanced biocompatibility. The synergistic interplay among the ultrasound-induced piezoelectric effect, NIR laser-triggered photothermal therapy, and MSN-mediated drug release results in a novel triple-modal therapy—piezoelectric dynamic, photothermal, and chemo. This integrated strategy effectively suppresses tumor growth and facilitates tumor ablation, holding great promise for future cancer therapeutics.

传统的肿瘤单药治疗由于其疗效有限且副作用大，严重阻碍了其广泛的临床应用。为了克服多模式协同治疗策略的进步，将多种治疗方式与互补机制相结合已成为提高肿瘤治疗效果的重要途径。在此背景下，我们开发了一种多功能纳米平台，命名为BaTiO3@MSN@ py - peg纳米颗粒（BMPP NPs），可以通过超声和近红外（NIR）激光照射组合激活。该纳米平台以压电材料钛酸钡（BTO）为中心，采用介孔二氧化硅（MSN）涂层有效封装化疗药物姜黄素（Cur），并进一步用聚吡咯（PPy）和聚乙二醇（PEG）修饰，以获得优异的光热转换能力和增强的生物相容性。超声诱导的压电效应、近红外激光触发的光热治疗和msn介导的药物释放之间的协同相互作用导致了一种新的三模态治疗——压电动力学、光热和化学。这种综合策略有效地抑制肿瘤生长，促进肿瘤消融，对未来的癌症治疗有很大的希望。

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引用次数: 0

Polydopamine-functionalized PCN-224-supported Pt-Pd bimetallic nanozyme with intrinsic oxidase activity for hydrogen peroxide-free ultrasensitive colorimetric sensing of ascorbic acid 具有内在氧化酶活性的聚多巴胺功能化pcn -224负载的Pt-Pd双金属纳米酶用于抗坏血酸的无过氧化氢超灵敏比色检测。

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces

Pub Date : 2026-01-02 DOI: 10.1016/j.colsurfb.2026.115413

Huan Luo , Shoubei Gao , Chenran Zhen , Haiyan Xiao , Yanshuai Cui , Longgang Wang

Ascorbic acid (AA), an essential water-soluble antioxidant in humans, plays a critical role in disease prevention and health maintenance, necessitating accurate detection methods. However, conventional H₂O₂-dependent colorimetric methods face inherent limitations, creating a demand for alternative detection strategies that operate independently of H₂O₂. To address this problem, a composite nanozyme (PCN-224-PDA-PdPt₃) was constructed by employing a zirconium-based porphyrin metal-organic framework (PCN-224) as a substrate, followed by sequential polydopamine (PDA) surface functionalization and PdPt₃ bimetallic nanoparticle deposition. The synthetic nanozyme exhibited exceptional oxidase-mimicking activity at pH 4.0 and 40 °C. Mechanism studies confirmed that its activity originates from the catalytic generation of reactive oxygen species (O₂•⁻ and ¹O₂) from dissolved oxygen. Leveraging this, an H₂O₂-independent colorimetric AA detection method was developed, which demonstrated a wide linear range (1–900 μM), a low detection limit (0.56 μM), and high selectivity against interfering species like amino acids and metal ions. The clinical applicability was further verified through satisfactory recoveries (96.84–104.46 %) and low RSD (< 5 %) in spiked human serum samples. Moreover, the nanozyme showed excellent biocompatibility with a hemolysis rate below 5 %. This work not only provides a robust and safe platform for biomedical detection but also paves the way for the rational design of multifunctional nanozymes for developing H₂O₂-independent sensing systems.

抗坏血酸（AA）是人体必需的水溶性抗氧化剂，在疾病预防和健康维护中起着至关重要的作用，需要准确的检测方法。然而，传统的依赖H2O2的比色方法面临固有的局限性，因此需要独立于H2O2的替代检测策略。为了解决这一问题，我们以锆基卟啉金属-有机骨架（PCN-224）为底物，依次进行聚多巴胺（PDA）表面功能化和PdPt3双金属纳米颗粒沉积，构建了复合纳米酶（PCN-224-PDA-PdPt3）。合成的纳米酶在pH 4.0和40 °C下表现出优异的氧化酶模拟活性。机理研究证实其活性来源于溶解氧催化生成活性氧（O2•⁻和1O2）。该方法线性范围宽（1 ~ 900 μM），检出限低（0.56 μM），对氨基酸和金属离子等干扰物具有较高的选择性。加标后的人血清样品加标回收率为96.84 ~ 104.46 %,RSD < 5 %，进一步验证了该方法的临床适用性。此外，纳米酶具有良好的生物相容性，溶血率低于5% %。这项工作不仅为生物医学检测提供了一个强大而安全的平台，而且为开发不依赖H₂O₂的传感系统的多功能纳米酶的合理设计铺平了道路。

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引用次数: 0