Dental Materials最新文献

{"title":"Direct ink writing with dental composites: A paradigm shift toward sustainable chair-side production","authors":"Po-Chun Tseng ,&nbsp;Dar-Bin Shieh ,&nbsp;Andreas Kessler ,&nbsp;Dalia Kaisarly ,&nbsp;Peter Rösch ,&nbsp;Karl-Heinz Kunzelmann","doi":"10.1016/j.dental.2024.08.002","DOIUrl":"10.1016/j.dental.2024.08.002","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the dimensional accuracy of occlusal veneers printed using a novel direct ink writing (DIW) system and a clinically approved dental composite.</div></div><div><h3>Methods</h3><div>A novel three-dimensional printer was developed based on the extrusion-based DIW principle. The printer, constructed primarily with open-source hardware, was calibrated to print with a flowable resin composite (Beautifil Flow Plus). The feasibility of this technology was assessed through an evaluation of the dimensional accuracy of 20 printed occlusal veneers using a laboratory confocal scanner. The precision was determined by pairwise superimposition of the 20 prints, resulting in a set of 190 deviation maps used to evaluate between-sample variations.</div></div><div><h3>Results</h3><div>Without material waste or residuals, the DIW system can print a solid occlusal veneer of a maxillary molar within a 20-minute timeframe. Across all the sampled surface points, the overall unsigned dimensional deviation was 30.1 ± 20.2 µm (mean ± standard deviation), with a median of 24.4 µm (interquartile range of 22.5 µm) and a root mean square value of 36.3 µm. The pairwise superimposition procedure revealed a mean between-sample dimensional deviation of 26.7 ± 4.5 µm (mean ± standard deviation; n = 190 pairs), indicating adequate precision. Visualization of the deviation together with the nonextrusion movements highlights the correlation between high-deviation regions and material stringing.</div></div><div><h3>Significance</h3><div>This study underscores the potential of using the proposed DIW system to create indirect restorations utilizing clinically approved flowable resin composites. Future optimization holds promise for enhancing the printing accuracy and increasing the printing speed.</div></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 11","pages":"Pages 1753-1761"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel matrix formulation for resin composite: Chemical and biomechanical characterization – Part 1","authors":"Julyana Dumas Santos Silva ,&nbsp;Letícia Nunes de Almeida ,&nbsp;Antônio Silva Machado ,&nbsp;Érica Miranda de Torres ,&nbsp;Eric de Souza Gil ,&nbsp;Cristhiane Gonçalves ,&nbsp;Luciano Morais Lião ,&nbsp;Germán Sanz Lobón ,&nbsp;Boniek Gontijo Vaz ,&nbsp;Lawrence Gonzaga Lopes ,&nbsp;Ricardo Menegatti","doi":"10.1016/j.dental.2024.07.032","DOIUrl":"10.1016/j.dental.2024.07.032","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the effects of adding cholesteryl methacrylate (CM) monomer to experimental composite resins and evaluate its impact on polymerization shrinkage force (PSF), Knoop microhardness (KHN), sorption and solubility (SS), vulnerability to spontaneous oxidation (VOE), porosity (BES), viscosity (V), and cross-link density (CLD). CM was synthesized, mixed with varying proportions of Bis-GMA, 70 wt% filler particles, and 40 % TEGDMA. The groups tested were: CM0 (60 % Bis-GMA), CM6 (54 % Bis-GMA/6 % CM), CM12 (48 % Bis-GMA/12 % CM), CM18 (42 % Bis-GMA/18 % CM) and CM24 (36 % Bis-GMA/24 % CM). The PSF was evaluated using a universal testing machine. KHN was measured with a 50 g load for 30 s. SS was determined according to ISO 4049:2009. VOE was measured with a three-electrode system in an electrochemical cell. BES images were obtained using an electron microscope to assess porosity. Viscosity was measured through rheological analysis. CLD was estimated from hardness readings before and after ethanol storage.</div></div><div><h3>Results</h3><div>CM6 (0.34 N) and CM12 (0.34 N) exhibited the lowest PSF values compared to CM0 (0.91 N). For KHN, CM6 (32.03) and CM12 (31.03) had higher values than CM0 (25.83) and were similar to CM18 (29.39) and CM24 (28.64). SS showed no significant differences among the groups. VOE indicated low vulnerability across all groups. CM12 had greater porosity compared to CM0 in BES images. CM0 had the lowest viscosity among the groups. No differences in CLD were observed among CM0, CM12, CM18, and CM24 regarding softening effects.</div></div><div><h3>Significance</h3><div>Adding CM to Bis-GMA/TEGDMA composite resins can reduce polymerization shrinkage force and increase the initial Knoop microhardness without affecting the other properties studied.</div></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 11","pages":"Pages e53-e62"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical and biological properties of dental materials and formulations with silica nanoparticles: A narrative review","authors":"Larissa Pavanello ,&nbsp;Iago Torres Cortês ,&nbsp;Rafaela Durrer Parolina de Carvalho ,&nbsp;Mayara Zaghi Dal Picolo ,&nbsp;Vanessa Cavalli ,&nbsp;Larissa Tavares Sampaio Silva ,&nbsp;Letícia Cristina Cidreira Boaro ,&nbsp;Polina Prokopovich ,&nbsp;Karina Cogo-Müller","doi":"10.1016/j.dental.2024.07.028","DOIUrl":"10.1016/j.dental.2024.07.028","url":null,"abstract":"<div><h3>Objective</h3><div>Silica nanoparticles (SNPs) have been extensively studied and used in different dental applications to promote improved physicochemical properties, high substance loading efficiency, in addition to sustained delivery of substances for therapeutic or preventive purposes. Therefore, this study aimed to review the SNPs applications in nanomaterials and nanoformulations in dentistry, discussing their effect on physicochemical properties, biocompatibility and ability to nanocarry bioactive substances.</div></div><div><h3>Data resources</h3><div>Literature searches were conducted on PubMed, Web of Science, and Scopus databases to identify studies examining the physicochemical and biological properties of dental materials and formulations containing SNPs. Data extraction was performed by one reviewer and verified by another</div></div><div><h3>Study selection</h3><div>A total of 50 were reviewed. <em>In vitro</em> studies reveal that SNPs improved the general properties of dental materials and formulations, such as microhardness, fracture toughness, flexural strength, elastic modulus and surface roughness, in addition to acting as efficient nanocarriers of substances, such as antimicrobial, osteogenic and remineralizing substances, and showed biocompatibility</div></div><div><h3>Conclusions</h3><div>SNPs are biocompatible, improve properties of dental materials and serve as effective carriers for bioactive substances</div></div><div><h3>Clinical significance</h3><div>Overall, SNPs are a promising drug delivery system that can improve dental materials biological and physicochemical and aesthetic properties, increasing their longevity and clinical performance. However, more studies are needed to elucidate SNPs short- and long-term effects in the oral cavity, mainly on in vivo and clinical studies, to prove their effectiveness and safety.</div></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 11","pages":"Pages 1729-1741"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of smart materials in minimally invasive dentistry – some research and clinical perspectives","authors":"M. Par ,&nbsp;L. Cheng ,&nbsp;J. Camilleri ,&nbsp;P. Lingström","doi":"10.1016/j.dental.2024.09.017","DOIUrl":"10.1016/j.dental.2024.09.017","url":null,"abstract":"<div><h3>Objectives</h3><div>Dental caries is one of the most prevalent bacteria-induced non-communicable diseases globally. It is known to be the top oral health burden in both developing and developed nations. There is substantial literature on the disease process and there is still debate on the extent of caries removal needed and the adequacy of the materials available to restore the lost tooth structure. The current review discusses the disease process together with the contemporary management of the carious lesion and also presents substantial evidence on novel materials and techniques that make minimally invasive dentistry predictable.</div></div><div><h3>Methods</h3><div>The written work presented shows the most relevant literature for the management of dental caries focusing on novel materials used in minimally invasive dentistry.</div></div><div><h3>Results</h3><div>There is still much to learn about specific antimicrobial and caries prevention mechanisms of novel materials. Materials that respond to a single or a few stimuli remain \"weakly intelligent\" in the face of the complex microenvironment in the oral cavity. Engineered systems that combine artificial intelligence and chemical engineering, are expected to possess higher intelligence, self-healing capabilities as well as environmental adaptability, and may be future promising research directions.</div></div><div><h3>Significance</h3><div>The targeted approach in managing dental caries will hopefully have a better clinical outcome. The strategies discussed are alternatives to the contemporary approach and will improve the clinical management.</div></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 11","pages":"Pages 2008-2016"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142338147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of the anti-Alzheimer drug GSK-3β antagonist on numerical modeling of the energy dissipation through the resin-dentin interface","authors":"Manuel Toledano ,&nbsp;Enrique Fernández-Romero ,&nbsp;Estrella Osorio ,&nbsp;Fátima S. Aguilera ,&nbsp;Christopher D. Lynch ,&nbsp;María T. Osorio ,&nbsp;Raquel Toledano ,&nbsp;Raquel Osorio","doi":"10.1016/j.dental.2024.09.005","DOIUrl":"10.1016/j.dental.2024.09.005","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to determine the viscoelastic performance and energy dissipation of conditioned dentin infiltrated with polymeric nanoparticles (NPs) doped with tideglusib (TDg) (TDg-NPs).</div></div><div><h3>Methods</h3><div>Dentin conditioned surfaces were infiltrated with NPs and TDg-NPs. Bonded interfaces were created, stored for 24 h and submitted to mechanical and thermal challenging. Resin-dentin interfaces were evaluated through nano-DMA/complex-loss-storage moduli-tan delta assessment and atomic force microscopy (AFM) analysis.</div></div><div><h3>Results</h3><div>Dentin infiltrated with NPs and load cycled attained the highest complex modulus at hybrid layer and bottom of hybrid layer. Intertubular dentin treated with undoped NPs showed higher complex modulus than peritubular dentin, after load cycling, provoking energy concentration and breakdown at the interface. After infiltrating with TDg-NPs, complex modulus was similar between peri-intertubular dentin and energy dissipated homogeneously. Tan delta at intertubular dentin was higher than at peritubular dentin, after using TDg-NPs and load cycling. This generated the widest bandwidth of the collagen fibrils and bridge-like mineral structures that, as sight of energy dissipation, fastened active dentin remodeling. TDg-NPs inducted scarce mineralization after thermo-cycling, but these bridging processes limited breakdown zones at the interface.</div></div><div><h3>Significance</h3><div>TDg-based NPs are then proposed for effective dentin remineralization and tubular seal, from a viscoelastic approach.</div></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 11","pages":"Pages 1909-1919"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142277750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Matrix metalloproteinases in dentin: Assessing their presence, activity, and inhibitors – a review of current trends","authors":"Lavanya Anumula ,&nbsp;Sindhu Ramesh ,&nbsp;Venkata Suneel Kumar Kolaparthi","doi":"10.1016/j.dental.2024.09.011","DOIUrl":"10.1016/j.dental.2024.09.011","url":null,"abstract":"<div><h3>Introduction</h3><div>Dentin integrity is a critical aspect of tooth structure, with matrix metalloproteinases (MMPs) playing a crucial role in dentinogenesis, caries formation, and dental bonding. It is crucial to accurately assess MMP activity to understand dentin pathophysiology and develop effective clinical strategies. Objectives: The study aimed to conduct a thorough review and comprehensive summary of diverse techniques employed in assessing MMPs in dentin. Data and sources: To conduct the research, electronic databases were systematically searched and manual citation searches were performed. A total of 621 articles were identified. After eliminating duplicates and irrelevant studies, 70 articles were included in the review. 25 articles with overlapping methodologies were also excluded. Study selection: The selection criteria were based on the relevance of the studies to MMPs and MMP inhibitors in dentin without regard to the study design. Only peer-reviewed articles published in English were included. The search was restricted to studies published until November 2022. Conclusion: The comprehensive analysis of various studies has yielded 37 techniques for evaluating MMPs and MMP inhibitors, which hold significant promise in creating diagnostic markers and devising targeted therapeutic interventions.</div></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 11","pages":"Pages 2051-2073"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longevity of posterior direct versus indirect composite restorations: A systematic review and meta-analysis","authors":"Christian Tennert,&nbsp;Christina Maliakal,&nbsp;Lazàro Suarèz Machado,&nbsp;Thomas Jaeggi,&nbsp;Hendrik Meyer-Lueckel,&nbsp;Johannes Wierichs Richard","doi":"10.1016/j.dental.2024.07.033","DOIUrl":"10.1016/j.dental.2024.07.033","url":null,"abstract":"<div><h3>Objectives</h3><div>The goal of this systemic review and meta-analysis was to compare the longevity of direct and indirect composite restorations in posterior teeth.</div></div><div><h3>Data</h3><div>Randomized controlled trials (RCT) investigating direct and indirect composite restorations in permanent posterior teeth.</div></div><div><h3>Sources</h3><div>Three electronic databases (PubMed, CENTRAL (Cochrane) and Embase) were screened. No language or time restrictions were applied. Study selection, data extraction and quality assessment were done in duplicate. Risk of bias and level of evidence was graded using Risk of Bias 2.0 tool and Grade Profiler 3.6.</div></div><div><h3>Results</h3><div>A total of 3056 articles were found by electronic databases. Finally, five RCTs were selected. Overall, 627 restorations of which 323 were direct and 304 indirect composite restorations have been placed in 279 patients (age: 28–81 years). The highest annual failure rates (AFR) were found for indirect restorations ranging from 0 % to 15.5 %. Lower AFR were found for direct restorations ranging from 0 % to 5.4 %. The most frequent failures were found to be chipping and fracture of the restoration followed by caries. Meta-analysis revealed that the failure rate for direct restorations was significantly lower than for indirect restorations (Risk Ratio (RR) [95 %CI] = 0.61 [0.47; 0.79]; very low level of evidence). Furthermore, all studies showed a high risk of bias.</div></div><div><h3>Conclusion</h3><div>Direct and indirect composite restorations can be recommended for large class II cavities including cusp coverage in posterior teeth for single tooth restoration. Meta-analysis revealed significantly lower relative risk to fail for direct composite restorations than for indirect restorations but results are with high risk of basis.</div></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 11","pages":"Pages e95-e101"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of different viscosity and chemical composition of flowable composite resins: A 48-month split-mouth double-blind randomized clinical trial","authors":"Romina Ñaupari-Villasante ,&nbsp;Byron Carpio-Salvatierra ,&nbsp;André de Freitas ,&nbsp;Thalita de Paris Matos ,&nbsp;Alejandra Nuñez ,&nbsp;Chane Tarden ,&nbsp;Marcos Oliveira Barceleiro ,&nbsp;Alessadra Reis ,&nbsp;Alessandro Loguercio","doi":"10.1016/j.dental.2024.07.034","DOIUrl":"10.1016/j.dental.2024.07.034","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the clinical performance of two flowable composites based on methacrylate and one based on ormocer in treating non-carious cervical lesions (NCCLs) after 48-month evaluation in a split-mouth double-blind clinical study design.</div></div><div><h3>Methods</h3><div>A total of 183 restorations were performed on NCCLs using a universal adhesive system (Futurabond U, Voco GmbH) with selective enamel etching on 27 participants: two participants received twelve restorations each, three received nine restorations each, and 22 participants received six restorations each. Three different flowable composites were employed (n = 61): a low-viscosity methacrylate-based composite (GrandioSO Flow, LVM), a high-viscosity methacrylate-based composite (GrandioSO Heavy Flow, HVM), and an ormocer-based flowable composite (Admira Fusion Flow, ORM). All restorations were evaluated using FDI and USPHS criteria after 48 months. Statistical analysis was conducted using Kaplan-Meier Survival analysis and Kruskal-Wallis analysis of variance rank (α = 0.05).</div></div><div><h3>Results</h3><div>After 48 months, 17 restorations were lost: LVM 6, HVM 9, ORM 2. The retention rates (95 % confidence interval) were 89.4 % for LVM, 80.4 % for HVM, and 95.6 % for ORM, with a significant difference between HVM vs. LVM and HVM vs. ORM (p &lt; 0.05). Minor defects were observed in 30 restorations for marginal staining criteria (LVM 12, HVM 10, ORM 8) and in 71 restorations for marginal adaptation criteria (LVM 24, HVM 20, ORM 27) without significant difference between groups (p &gt; 0.05). No restorations showed postoperative sensitivity or recurrence of caries.</div></div><div><h3>Significance</h3><div>The increased viscosity of flowable composites could reduce the clinical longevity in NCCLs after 48 months. Ormocer-based and low-viscosity methacrylate-based flowable composites showed a successful clinical performance in NCCLs after 48 months.</div></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 11","pages":"Pages 1798-1807"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are we approaching the development of a novel calcium phosphate-based bioceramic dental material?","authors":"Letícia Florindo Pereira ,&nbsp;Lucas José de Azevedo-Silva ,&nbsp;Pedro Rodrigues Minim ,&nbsp;Paulo Noronha Lisboa-Filho ,&nbsp;Carlos Alberto Fortulan ,&nbsp;Jason Alan Griggs ,&nbsp;Brunna Mota Ferrairo ,&nbsp;Ana Flávia Sanches Borges","doi":"10.1016/j.dental.2024.07.019","DOIUrl":"10.1016/j.dental.2024.07.019","url":null,"abstract":"<div><h3>Objectives</h3><div>Develop a sustainable bovine hydroxyapatite dental ceramic with the addition of titanium dioxide (TiO₂) nanoparticles (5 % and 8 % by weight), analyzing the outcome of this addition to the microstructure, as well as its mechanical and chemical properties, in order to evaluate whether they satisfy the International Organization for Standardization (ISO) 6872:2015 for dental ceramics or not.</div></div><div><h3>Methods</h3><div>Disks were obtained through uniaxial followed by isostatic pressing from bovine hydroxyapatite powder and TiO₂ nanoparticles and sintered at 1300ºC for 2 h. Three experimental groups were developed (HA, HA+5 %TiO₂ and HA+8 %TiO₂) and subjected to X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), indentation fracture (IF), biaxial flexural strength (BFS) and chemical solubility test.</div></div><div><h3>Results</h3><div>XRD revealed, for HA group, the appearance of a peak corresponding to b-tricalcium phosphate (ß-TCP). For HA+ 5 %TiO₂ and HA+ 8 %TiO_2, the entire composition was converted into ß-TCP and calcium titanate (CaTiO₃). The SEM images showed a dense ceramic matrix and a uniform distribution of another phase in groups with TiO₂ nanoparticles. HA+ 5 %TiO₂ (1.40 ± 0.18 MPa.m^1/2) and HA+ 8 %TiO₂ (1.32 ± 0.18 MPa.m^1/2) showed significantly higher fracture toughness values than HA (0.67 ± 0.09 MPa.m^1/2). HA showed significantly higher characteristic stress (295.8 MPa) in comparison to groups with 5 % (235.1 MPa) and 8 % (214.4 MPa) TiO₂ nanoparticles. Differences were not observed between the Weibull modulus values. The solubility results indicated that all experimental ceramics were above the 2000 ug/cm² limit set by the ISO 6872:2015.</div></div><div><h3>Significance</h3><div>This study proposed the development and characterization of a new ceramic for dental prosthesis made from HA extracted from bovine bones, with the intention of reusing these solids waste and transforming them into a sustainable and low-cost material. Although the experimental calcium phosphate ceramic with additions of 5 % and 8 % of TiO₂ achieved desirable mechanical properties, the chemical solubility values were very high.</div></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 11","pages":"Pages 1843-1853"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142102789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of antibacterial dual-cure dental resin composites via tetrapod-shaped zinc oxide incorporation","authors":"Hwalim Lee ,&nbsp;Yu-Jin Kim ,&nbsp;Ye-Jin Yang ,&nbsp;Jung-Hwan Lee ,&nbsp;Hae-Hyoung Lee","doi":"10.1016/j.dental.2024.07.021","DOIUrl":"10.1016/j.dental.2024.07.021","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate the effects of incorporating the 0–20 wt% tetrapod-shaped zinc oxide (tZnO) whiskers on the mechanical, antibacterial, and cytotoxic properties exhibited by experimental dual-cure resin composites.</div></div><div><h3>Methods</h3><div>Commercially obtained tZnO whiskers underwent surface modification using 3-methacryloxypropyltrimethoxysilane (γ-MPS). Subsequently, four groups of resin composites containing 0, 5, 10, and 20 wt% silanized tZnO along with barium borosilicate glass (BaBSG) fillers were fabricated while maintaining total filler loading at 60 wt%. Mechanical properties were examined utilizing specimens produced adhering to ISO 4049:2019 guidelines where applicable. Depth of cure was quantified immediately, while three-point flexural strength, flexural modulus, fracture toughness, Vickers hardness, compressive strength, and diametral tensile strength were assessed after 24 h of storage in 37 °C distilled water. Planktonic bacteria of <em>Streptococcus mutans</em> (<em>S</em>. <em>mutans</em>) were cultured and tested for antibacterial activity using disk diffusion and microbial anti-adhesion assays. Cytotoxicity was examined by preparing extracts from specimens in a cell culture medium and exposing stem cells from human exfoliated deciduous teeth (SHED) to serial dilutions of these extracts, then assessing cell viability and survival using CCK-8 assay and live/dead staining.</div></div><div><h3>Results</h3><div>Elevating tZnO loading yielded significant reductions in depth of cure, compressive (from 296.4 to 254.6 MPa), and diametral tensile strength (from 42.7 to 31.0 MPa), while flexural strength (91.3–94.1 MPa), flexural modulus (6.4–6.6 GPa), fracture toughness (0.96–1.04 MPa·m^0.5), and Vickers hardness (36.5–37.4 kgf·mm⁻²) remained the same. Composites integrating tZnO displayed markedly enhanced antibacterial activity against <em>S</em>. <em>mutans</em>, based on anti-adhesion tests and live/dead staining. No cytotoxicity was observed for SHED treated with extracts from resin composites possessing up to 20 wt% tZnO whiskers.</div></div><div><h3>Significance</h3><div>This study demonstrates that incorporating up to 20 wt% silanized tZnO in place of traditional barium glass particles appreciably enhances dual-cure resin composite antibacterial function against <em>S</em>. <em>mutans</em> without compromising mechanical properties.</div></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 11","pages":"Pages 1762-1772"},"PeriodicalIF":4.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}