Dental Materials最新文献

{"title":"Critical evaluations on the crystallographic properties of translucent dental zirconia ceramics stabilized with 3-6 mol% yttria","authors":"","doi":"10.1016/j.dental.2024.06.027","DOIUrl":"10.1016/j.dental.2024.06.027","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aimed to determine the crystalline phase composition of 3–6 mol% yttria-stabilized zirconia (3–6YSZ), specifically investigating the presence of tetragonal (<em>t</em>), cubic (<em>c</em>), and/or additional yttria-rich tetragonal (<em>t’</em>) phase.</p></div><div><h3>Methods</h3><p>Laboratory-fabricated specimens comprising 3–5YSZ, resembling translucent dental zirconia ceramics (TZ specimens), and a blend of 3YSZ and 8YSZ, representing a <em>c</em>-phase reference, were prepared. Additionally, 25 dental zirconia products stabilized with 3–6 mol% yttria were analyzed. Whole X-ray diffraction (XRD) patterns were obtained for Rietveld analysis, complemented by fine scanning in the 2θ region from 72º to 76º for qualitative phase analysis. Moreover, yttria concentrations in each specimen were determined using X-ray fluorescence (XRF) spectroscopy.</p></div><div><h3>Results</h3><p>In the 2θ region from 72º to 76º, TZ and dental zirconia product specimens displayed four peaks attributed to <em>t</em>- and <em>t’</em>-phases, but the <em>c</em>-phase peak was absent. Rietveld analysis of the whole XRD patterns, utilizing a <em>t</em>-<em>t’</em> model, demonstrated the <em>t</em>-phase fraction ranging from 86 mass% in 3YSZ to 11 mass% in 6YSZ. Rietveld analysis appeared reliable, as the yttria contents calculated based on lattice parameters aligned well with those measured by XRF. This study established that dental 3–6YSZ consisted of yttria-lean <em>t</em>- and yttria-rich <em>t’</em>-phases.</p></div><div><h3>Significance</h3><p>The present study enhances understanding of the crystalline structure of dental zirconia ceramics. Future crystallographic analyses of these ceramics should consider the presence of <em>t</em>- and <em>t’</em>-phases.</p></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 9","pages":"Pages 1425-1451"},"PeriodicalIF":4.6,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0109564124001817/pdfft?md5=c6cc384e2122857875d5c3f9d7b8eba4&pid=1-s2.0-S0109564124001817-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141464812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tricalcium phosphate (TCP) and hydroxyapatite (HA) based light-cured biomaterial for vital pulp therapy","authors":"","doi":"10.1016/j.dental.2024.06.009","DOIUrl":"10.1016/j.dental.2024.06.009","url":null,"abstract":"<div><h3>Objectives</h3><p>Evaluate a new light-cured material with better properties for vital pulp therapy.</p></div><div><h3>Methods</h3><p><span>Light-cured resin materials consisted of polyethylene glycol<span><span> (600) diacrylate mixed with different ratios of TCP<span> to HA<span>. In addition to the temperature change (n = 5 for each subgroup) were tested, cell viability and </span></span></span>Alizarin Red Staining (ARS) assay were also tested </span></span><em>in vitro</em><span><span> on human dental pulp cells (n = 6 for each subgroup). Lastly, the material was then compared with </span>Biodentine and control groups in the molars of Wistar rats </span><em>in vivo</em> for histology assessment.</p></div><div><h3>Results</h3><p>The temperature change for the new materials were under 5 degrees Celsius. For the <em>in vitro</em><span><span> assessments, there was no significant difference on day 3 and day 7 for cell viability test. ARS assay showed significantly higher mineralized nodule formation when treated without induction medium for Group D and Biodentine on day 10 compared to Group C and control. On the contrary, Biodentine and control groups treated with induction medium showed significant higher mineralization than the new materials. Histology assessments demonstrated higher mineralized content in Group D and Biodentine on week 3 and week 6. The </span>inflammatory cells in the dental pulp complex of the Biodentine group resolved on week 6 while the inflammation resolved in Group D on week 3.</span></p></div><div><h3>Significance</h3><p>The new material exhibits low heat production<span>, low cytotoxicity, and good calcium ion release capability. Compared to traditional materials, it has shorter setting time and better aesthetic outcomes, making it highly suitable for use in vital pulp therapy.</span></p></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 9","pages":"Pages 1417-1424"},"PeriodicalIF":4.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141464810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in vitro evaluation of the fatigue behavior of resin composite materials as part of a translational research cycle","authors":"","doi":"10.1016/j.dental.2024.06.010","DOIUrl":"10.1016/j.dental.2024.06.010","url":null,"abstract":"<div><h3>Purpose</h3><p>This study aimed to reproduce and translate clinical presentations in an <em>in vitro</em> set-up and evaluate laboratory outcomes of mechanical properties (flexural strength, fatigue resistance, wear resistance) and link them to the clinical outcomes of the employed materials in the Radboud Tooth Wear Project (RTWP).</p></div><div><h3>Materials and methods</h3><p>Four dental resin composites were selected. 30 discs (Ø12.0 mm, 1.2 mm thick) were fabricated for each of Clearfil TM AP-X (AP), Filtek TM Supreme XTE (FS), Estenia TM C&amp;B (ES), and Lava Ultimate (LU). Cyclic loading (200 N, 2 Hz frequency) was applied concentrically to 15 specimens per group with a spherical steatite indenter (r = 3.18 mm) in water in a contact-load-slide-liftoff motion (105 cycles). The wear scar was analysed using profilometry and the volume loss was digitally computed. Finally, all specimens were loaded (fatigued specimens with their worn surface loaded in tension) until fracture in a biaxial flexure apparatus. The differences in volume loss and flexural strength were determined using regression analysis.</p></div><div><h3>Results</h3><p>Compared to AP and FS, ES and LU showed a significantly lower volume loss (p &lt; 0.05). Non-fatigued ES specimens had a similar flexural strength compared to nonfatigued AP, while non-fatigued FS and LU specimens had a lower flexural strength (p &lt; 0.001; 95 %CI: −80.0 – 51.8). The fatigue test resulted in a significant decrease of the flexural strength of ES specimens, only (p &lt; 0.001; 95 %CI: −96.1 – −54.6).</p></div><div><h3>Clinical relevance</h3><p>These outcomes concur with the outcomes of clinical studies on the longevity of these composites in patients with tooth wear. Therefore, the employed laboratory test seems to have the potential to test materials in a clinically relevant way.</p></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 9","pages":"Pages 1409-1416"},"PeriodicalIF":4.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0109564124001519/pdfft?md5=f67e98ad2f3685eb65b7bbe3c14e58ec&pid=1-s2.0-S0109564124001519-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study on the mechanical and antibacterial properties of BPA-free dental resin composites","authors":"","doi":"10.1016/j.dental.2024.06.024","DOIUrl":"10.1016/j.dental.2024.06.024","url":null,"abstract":"<div><h3>Objective</h3><p>The commonly used base monomer utilized in resinous commercial dental restorative products is bis-GMA which is derived from bisphenol-A (BPA) - a well-known compound which may disrupt endocrine functions. To address concerns about its leaching into the oral environment and to optimize the quality of dental composites, a BPA-free alternative base monomer, fluorinated urethane dimethacrylate (FUDMA), was designed by modifying a UDMA monomer system.</p></div><div><h3>Methods</h3><p>Nine groups of composites were prepared by mixing the base monomers and TEGDMA in a ratio of 70/30 wt% to which were added silanized glass particles (mean diameter: 0.7 µm) in 3 different volume fractions (40, 45, and 50 vol%). Bis-GMA and UDMA base monomers were used as control groups in the same ratios. Various properties including degree of conversion (DC), flexural strength (FS) and flexural modulus (FM), water sorption (WS), solubility (SL), surface hardness and roughness, and initial adhesion property against <em>S.mutans</em> were investigated. One-way analysis of variance followed by Bonferroni test at α = 0.05 was used to analyze the results.</p></div><div><h3>Results</h3><p>A significant difference in FS between FUDMA-based composite with 40 vol% filler (120.3 ± 10.4 MPa) and Bis-GMA-based composite with the same filler fraction (105.8 ± 10.0 MPa) was observed but there was no significant difference among other groups. The UDMA based group exhibited the highest WS (1.3 ± 0.3 %). Bis-GMA showed greater initial bacterial adhesion but was not statistically different from the other groups (p = 0.082).</p></div><div><h3>Significance</h3><p>FUDMA-based resin composites exhibit comparable mechanical and bacterial adhesion properties compared with Bis-GMA and UDMA-based composites. The FUDMA composites show positive outcomes indicating they could be used as substitute composites to Bis-GMA-based composites.</p></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 8","pages":"Pages e31-e39"},"PeriodicalIF":4.6,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achieving property enhancements in dental resin composites via reduced concentrations of camphorquinone within a ternary initiator system","authors":"","doi":"10.1016/j.dental.2024.06.022","DOIUrl":"10.1016/j.dental.2024.06.022","url":null,"abstract":"<div><h3>Objectives</h3><p>The study aimed to assess the impact of diphenyliodonium hexafluorophosphate (DPI) on the physicochemical properties of experimental resin composites (ECRs) featuring reduced concentrations of camphorquinone (CQ)/amine.</p></div><div><h3>Methods</h3><p>Five concentrations of CQ (0.125, 0.25, 0.5, 0.75, and 1 mol%) with dimethylaminoethyl amine benzoate (EDAB) in a 1:2 mol% ratio (CQ:EDAB) were incorporated into a 50:50 mass% monomer blend of bisphenol glycidyl methacrylate (BisGMA) and triethyleneglycol dimethacrylate (TEGDMA). An additional 5 groups with the same CQ:EDAB concentrations had 0.5 mol% DPI added. Each resin group contained 60 wt% of 0.7 µm barium-alumino-silicate glass. Light transmission (n = 3), real-time degree of polymerization (n = 3), temperature change during polymerization (n = 5), polymerization shrinkage strain (n = 3), flexural strength, and modulus (n = 12), as well as water sorption and solubility (n = 5), were evaluated. Data were analyzed using two-way ANOVA and Tukey's post-hoc test (α = 0.05).</p></div><div><h3>Results</h3><p>Light transmission was reduced in groups containing 0.125 and 0.25 mol% of CQ without DPI. DPI increased temperature, degree and rate of polymerization, despite the reduction in CQ/amine concentration. Additionally, there was an increase in polymerization shrinkage strain, flexural strength and modulus, and a reduction in water sorption and solubility in ECRs with DPI, even with lower concentrations of CQ/EDAB.</p></div><div><h3>Significance</h3><p>DPI improved the assessed properties of composites across various concentrations of CQ/EDAB, showing the benefit of reducing the quantity of CQ used without compromising the properties and curing of the resin composites.</p></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 9","pages":"Pages 1400-1408"},"PeriodicalIF":4.6,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0109564124001775/pdfft?md5=2ed1510fa690428fd841db0b4752c9e2&pid=1-s2.0-S0109564124001775-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicon impacts collagen remodelling and mineralization by human dental pulp stem cells in 3D pulp-like matrices","authors":"","doi":"10.1016/j.dental.2024.06.021","DOIUrl":"10.1016/j.dental.2024.06.021","url":null,"abstract":"<div><h3>Objectives</h3><p>Silicon-releasing biomaterials are widely used in the field of dentistry. However, unlike bone, very little is known about the role of silicon on dental tissue formation and repair. This study investigates the influence of silicic acid on the survival, differentiation and mineralizing ability of human dental pulp stem cells (hDPSCs) in 3D pulp-like environments</p></div><div><h3>Methods</h3><p>Dense type I collagen hydrogels seeded with hDPSCs were cultured over 4 weeks in the presence of silicic acid at physiological (10 μM) and supraphysiological (100 μM) concentrations. Cell viability and proliferation were studied by Alamar Blue and live/dead staining. The collagen network was investigated using second harmonic generation imaging. Mineral deposition was monitored by histology and scanning electron microscopy. Gene expression of mineralization- and matrix remodeling-associated proteins was studied by qPCR.</p></div><div><h3>Results</h3><p>Presence of silicic acid did not show any significant influence on cell survival, metabolic activity and gene expression of key mineralization-related proteins (ALP, OCN, BSP). However, it induced enhanced cell clustering and delayed expression of matrix remodeling-associated proteins (MMP13, Col I). OPN expression and mineral deposition were inhibited at 100 μM. It could be inferred that silicic acid has no direct cellular effect but rather interacts with the collagen network, leading to a modification of the cell-matrix interface.</p></div><div><h3>Significance</h3><p>Our results offer advanced insights on the possible role of silicic acid, as released by pulp capping calcium silicates biomaterials, in reparative dentine formation. More globally, these results interrogate the possible role of Si in pulp pathophysiology.</p></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 9","pages":"Pages 1390-1399"},"PeriodicalIF":4.6,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0109564124001799/pdfft?md5=dcd659bf561a1c79547d9166923789e8&pid=1-s2.0-S0109564124001799-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of low shrinkage Bis-EFMA based bulk-fill dental resin composites","authors":"","doi":"10.1016/j.dental.2024.06.025","DOIUrl":"10.1016/j.dental.2024.06.025","url":null,"abstract":"<div><h3>Objectives</h3><p><span>The purpose of this study was evaluating the performance of new Bis-EFMA based bulk-fill composites with common methacrylate based composites and commercial </span>dental composites.</p></div><div><h3>Methods</h3><p><span><span>The Bis-EFMA monomer<span><span> was synthesized and the novel Bis-EFMA based bulk-fill composites were prepared. The resin composite samples were co-cultured with human gingival epithelial cells and </span>human dental pulp stem cells<span><span> to test the biocompatibility. The edge adaptation was observed under a combination of stereoscope and </span>scanning electron microscope<span>. The internal hardness was measured using a Vickers </span></span></span></span>microhardness<span> tester after one-time filling of cavities prepared in extracted teeth. After friction and wear test on the surface of the resin composites, the surface morphology and volume wear of each group were measured by the optical profilometer. The color stability was measured by a </span></span>colorimeter.</p></div><div><h3>Results</h3><p><span><span>Direct contact with human gingival epithelial cells and human dental pulp stem cells did not cause significant changes in their growth density and morphology, indicating </span>good biocompatibility of Bis-EFMA group (</span><em>p</em> &gt; 0.05). The continuous margin proportion of the Bis-EFMA group was as good as commercial bulk-fill composites (<em>p</em><span> &gt; 0.05). The sectional microhardness<span> results showed that the Bis-EFMA group had the highest microhardness. After the friction and wear test, the volume wear of the Bis-EFMA group was minimal, indicating its good wear resistance and mechanical strength. Color changes in all resin groups after 28 days of immersion were within the clinically acceptable range.</span></span></p></div><div><h3>Significance</h3><p>The addition of Bis-EFMA demonstrated excellent biocompatibility, edge adaptation and color stability comparable to commonly used clinical bulk-fill composites, along with preferable mechanical strength, friction and wear resistance. Bis-EFMA based bulk-fill composites have the potential to be employed as a bulk filling material<span> in commercial dental composite applications.</span></p></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 9","pages":"Pages 1378-1389"},"PeriodicalIF":4.6,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141430982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of monomer type, filler size, and filler content of three resin cements on the color stability of laminate veneers exposed to accelerated aging","authors":"","doi":"10.1016/j.dental.2024.06.001","DOIUrl":"10.1016/j.dental.2024.06.001","url":null,"abstract":"<div><h3>Statement of problem</h3><p>Commercially available resin cements consist of various filler sizes, filler content and monomers, and it is unclear which of these factors have the greatest effect on the color stability of laminate veneers.</p></div><div><h3>Objectives</h3><p>To evaluate the color stability of lithium disilicate-reinforced laminate veneers inserted with three commercial resin cements with various filler sizes/contents and monomers upon accelerated aging.</p></div><div><h3>Methods</h3><p>Veneers were fabricated and cemented on resin abutments using three commercially available resin cements comprised of two different monomers and varying filler sizes/contents: 1) triethylene glycol dimethacrylate, TEGDMA (RelyX™ Veneer = 0.6 µm/66 %, Calibra® Esthetic Light Cure =1.2 µm/65 %); and 2) urethane dimethacrylate, UDMA (Variolink Esthetic LC = 0.1 µm/38 %). A total of 60 specimens were fabricated (n = 20 for each cement). The relative number of particles (N) and relative surface area (A) were calculated for each filler size/content. Color coordinates (L*, a*, b*) were measured, and color change (ΔE₀₀) was calculated after cementation and following aging at 150, 300, 450, and 600 h using xenon light. Differences in color coordinates and color change were determined using repeated measures ANOVA followed by Tukey's post hoc test (α = .05). A post-hoc power analysis was performed to confirm reliability of the results.</p></div><div><h3>Results</h3><p>Based on a post-hoc power analysis of a repeated measures ANOVA with two between-factors and 1 within-factor, we had 89 % power to detect a difference of effect by cement type, 10 % power to detect a difference by shade, and 100 % power to detect a difference of effect by aging. The UDMA-based cement (0.1 µm/38 %) was least affected by aging, despite having the largest number of particles (N = 1010) and largest particle surface area (A = 7.02). The TEGDMA-based cements exhibited a significant color change, with 0.6 µm/66 % (A = 2.03, N = 8.12) producing a larger ΔE₀₀ than 1.2 µm/65 % (A = 1.00, N = 1.00).</p></div><div><h3>Conclusions</h3><p>Among the commercial cements tested, UDMA-based resin (0.1 µm/38 %) provided better color stability than TEGDMA-based resin cements. The color change after aging was affected by the relative surface area and relative number of particles for the TEGDMA-based resin cement (0.6 µm/66 % and 1.2 µm/65 %), with a larger surface area and a higher relative number of particles, accelerated color change with aging. The present study demonstrates a novel approach to determine color stability for any resin cement with particulate filler.</p></div><div><h3>Clinical implications</h3><p>The dental practitioner should be selective in choosing a commercial light cure cementation product for laminate veneers, as UDMA containing resin cement is more resistant to color changes over time than TEGDMA, regardless of the filler size/content.</p></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 8","pages":"Pages e23-e30"},"PeriodicalIF":4.6,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141431002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Permeability of triamcinolone acetonide, released from mucoadhesive films, through a buccal mucosa-mimetic barrier: Permeapad™","authors":"","doi":"10.1016/j.dental.2024.06.016","DOIUrl":"10.1016/j.dental.2024.06.016","url":null,"abstract":"<div><h3>Objectives</h3><p>The permeability of triamcinolone acetonide (TA), from bilayer mucoadhesive buccal films, through a biomimetic membrane, Permeapad™, was investigated employing Franz diffusion cell. The delivery systems composition and ethyl cellulose (EC) backing layer, on drug permeability, were assessed.</p></div><div><h3>Methods</h3><p>Three TA-loaded films were tested; hydroxypropyl methylcellulose (HPMC K4M; bilayer [F1] and monolayer), HPMC K4M/Polyvinylpyrrolidone (PVP): 90/10 [F2], and HPMC K15M film [F3]. All films contained propylene glycol (PG-plasticiser). TA solution alone was used as a control. TA permeability via a Permeapad™ barrier, simulating buccal mucosa, was assessed over 8 h using a Franz diffusion cell. TA permeated into the receptor compartment, released in the donor compartment, and located on/within the Permeapad™ barrier were analysed using UV-spectrophotometer.</p></div><div><h3>Results</h3><p>45.7 % drug retention within the Permeapad™ barrier was delivered from F1 (highest). F1, F2, and F3 significantly improved the TA’s permeability through Permeapad™, compared to TA solution alone (e.g., 8.5 % TA-solution, 21.5 %-F1), attributed to the synergy effect of HPMC and propylene glycol acting as penetration enhancers. F1 displayed a significant increase in drug permeability (receptor compartment; 21.5 %) compared to F3 (17.0 %). PVP significantly enhanced drug permeability (27.5 %). Impermeable EC backing layer controlled unidirectional drug release and reduced drug loss into the donor compartment (e.g., ∼28 % for monolayer film to ∼10 % for bilayer film, F1).</p></div><div><h3>Significance</h3><p>The mucoadhesive films demonstrated improved TA permeability via Permeapad™. The findings suggest that these bilayer mucoadhesive films, particularly F1, hold promise for the effective topical treatment of oral mucosa disorders, such as recurrent aphthous stomatitis and oral lichen planus.</p></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 9","pages":"Pages 1372-1377"},"PeriodicalIF":4.6,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0109564124001581/pdfft?md5=a82b18d9a685e969cc76ee3d2bd1d93d&pid=1-s2.0-S0109564124001581-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141430983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of baghdadite (Ca3ZrSi2O9) cements for the application as novel endodontic filling materials","authors":"","doi":"10.1016/j.dental.2024.05.026","DOIUrl":"10.1016/j.dental.2024.05.026","url":null,"abstract":"<div><h3>Objectives</h3><p>Baghdadite (Ca₃ZrSi₂O₉) cements of various composition have been investigated in this study regarding an application as endodontic filling materials.</p></div><div><h3>Methods</h3><p>Cements were either obtained by mixing mechanically activated baghdadite powder with water (maBag) or by subsequently substituting the ß-tricalcium phosphate (ß-TCP) component in a brushite forming calcium phosphate cement. The cements were analyzed for their mechanical performance, injectability, radiopacity, phase composition and antimicrobial properties.</p></div><div><h3>Results</h3><p>The cements demonstrated sufficient mechanical performance with a compressive strength of ∼1 MPa (maBag) and 2.3 – 17.4 MPa (substituted calcium phosphate cement), good injectability &gt; 80 % depending on the powder to liquid ratio and an intrinsic radiopacity of 1.13 – 2.05 mm aluminum equivalent. Immersion in artificial saliva proved their bioactivity by the formation of calcium phosphate and calcium silicate precipitates on the cement surface. The bacterial activity of <em>Staphylococcus aureus</em> cultured on the surface of the cements was found to be similar compared to clinical standard ProRoot MTA cement or even reduced by a factor of 3 for <em>Streptococcus mutans</em>.</p></div><div><h3>Significance</h3><p>In combination with their antibacterial properties, baghdadite cements are thought to have the potential to fulfil the clinical requirements for endodontic filling materials.</p></div>","PeriodicalId":298,"journal":{"name":"Dental Materials","volume":"40 9","pages":"Pages 1364-1371"},"PeriodicalIF":4.6,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0109564124001246/pdfft?md5=ed16838169369752ef00adc0baa750d4&pid=1-s2.0-S0109564124001246-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}