首页 > 最新文献

IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology最新文献

英文 中文
Reconfigurable Intelligent Surface-Aided Indoor Radar Monitoring: A Feasibility Study 可重构智能地面辅助室内雷达监测:可行性研究
IF 3.2 Q1 Physics and Astronomy Pub Date : 2023-08-14 DOI: 10.1109/JERM.2023.3298730
Marco Mercuri;Emilio Arnieri;Raffaele De Marco;Pierangelo Veltri;Felice Crupi;Luigi Boccia
The application of radar technology in indoor people monitoring has opened up new avenues, such as localization and tracking, vital signs monitoring, and fall detection. Nevertheless, one of the significant challenges facing radar systems is the issue of indoor multipath propagation, which results in radar ghosts that can diminish the detection accuracy or even compromise the monitoring process entirely. This study delves into the utilization of reconfigurable intelligent surfaces (RISs) in radar-based indoor people localization. Thanks to the use of RIS, targets can be tracked from multiple orientations, achieving a more precise estimation of the propagation channel and in turn mitigating the effects of indoor multipath propagation. As a result, the detection performance of the radar system can be improved without increasing the radar's complexity. Empirical evidence gathered from experiments conducted in a laboratory environment has demonstrated the feasibility of the proposed approach in accurately locating multiple subjects in a two-dimensional (2-D) space while being able to reject radar ghosts. Practical implications of this novel approach include the development of smart building systems, Internet of Things (IoT), telemedicine, Hospital 4.0, automated nurse call solutions, ambient assisted living, firefighter tracking, and security applications.
雷达技术在室内人员监测中的应用开辟了定位与跟踪、生命体征监测、跌倒检测等新途径。然而,雷达系统面临的一个重大挑战是室内多径传播问题,它会导致雷达鬼影,从而降低探测精度,甚至完全危及监测过程。本研究探讨了可重构智能表面(RISs)在基于雷达的室内人物定位中的应用。由于RIS的使用,可以从多个方向跟踪目标,实现对传播信道的更精确估计,从而减轻室内多径传播的影响。在不增加雷达复杂性的前提下,提高了雷达系统的探测性能。在实验室环境中进行的实验中收集的经验证据表明,所提出的方法在二维(2-D)空间中准确定位多个受试者的可行性,同时能够拒绝雷达幽灵。这种新方法的实际意义包括智能建筑系统、物联网(IoT)、远程医疗、医院4.0、自动护士呼叫解决方案、环境辅助生活、消防员跟踪和安全应用的发展。
{"title":"Reconfigurable Intelligent Surface-Aided Indoor Radar Monitoring: A Feasibility Study","authors":"Marco Mercuri;Emilio Arnieri;Raffaele De Marco;Pierangelo Veltri;Felice Crupi;Luigi Boccia","doi":"10.1109/JERM.2023.3298730","DOIUrl":"10.1109/JERM.2023.3298730","url":null,"abstract":"The application of radar technology in indoor people monitoring has opened up new avenues, such as localization and tracking, vital signs monitoring, and fall detection. Nevertheless, one of the significant challenges facing radar systems is the issue of indoor multipath propagation, which results in radar ghosts that can diminish the detection accuracy or even compromise the monitoring process entirely. This study delves into the utilization of reconfigurable intelligent surfaces (RISs) in radar-based indoor people localization. Thanks to the use of RIS, targets can be tracked from multiple orientations, achieving a more precise estimation of the propagation channel and in turn mitigating the effects of indoor multipath propagation. As a result, the detection performance of the radar system can be improved without increasing the radar's complexity. Empirical evidence gathered from experiments conducted in a laboratory environment has demonstrated the feasibility of the proposed approach in accurately locating multiple subjects in a two-dimensional (2-D) space while being able to reject radar ghosts. Practical implications of this novel approach include the development of smart building systems, Internet of Things (IoT), telemedicine, Hospital 4.0, automated nurse call solutions, ambient assisted living, firefighter tracking, and security applications.","PeriodicalId":29955,"journal":{"name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136116504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidermal RFID-Based Thermal Monitoring Sheet (R-TMS) for Microwave Hyperthermia 基于射频识别的表皮热监测片(R-TMS)用于微波热疗
IF 3.2 Q1 Physics and Astronomy Pub Date : 2023-08-08 DOI: 10.1109/JERM.2023.3299525
Francesco Lestini;Nicoletta Panunzio;Gaetano Marrocco;Cecilia Occhiuzzi
Hyperthermia is an anti-cancer treatment that exploits the interaction between high-power electromagnetic fields and restricted regions of human tissues releasing a great amount of power to locally increase tissues temperature. Due to the high power, dangerous hot-spots may occur on the skin so that continuous monitoring of superficial temperature distribution is required. Thermal Monitoring Sheets (TMSs), which are grids of several wired temperature sensors, are currently used in clinical practice; however, they have some limitations in terms of poor spatial resolution, thermal conduction errors, and complex application procedures. Epidermal electronics associated with passive Ultra High Frequency (UHF) Radio Frequency IDentification (RFID) sensing technology could represent an attractive alternative thanks to its wireless nature and limited invasiveness. In this framework, this article proposes an innovative TMS based on battery-less RFID sensors (R-TMS). It comprises a planar grid of circular loop antennas with temperature-sensing-oriented ICs that can sample skin temperature without interfering with hyperthermia treatment. The system proved capable of monitoring skin temperature via wireless data transmission with a higher spatial resolution that state-of-the-art devices. The physical rationale, the design, and the experimentation of the R-TMS are here presented to validate the proposed approach and evaluate its feasibility from the electromagnetic perspective.
热疗是一种抗癌疗法,它利用高功率电磁场与人体组织受限区域之间的相互作用,释放大量能量,以局部提高组织温度。由于功率大,皮肤可能出现危险的热点,因此需要持续监测表面温度分布。热监测片(tms)是由几个有线温度传感器组成的网格,目前用于临床实践;然而,它们在空间分辨率差、热传导误差和应用程序复杂等方面存在一定的局限性。由于其无线特性和有限的侵入性,与无源超高频(UHF)射频识别(RFID)传感技术相关的表皮电子技术可能是一种有吸引力的替代方案。在此框架下,本文提出了一种基于无电池RFID传感器(R-TMS)的创新TMS。它包括圆形环状天线的平面网格,带有面向温度传感的集成电路,可以在不干扰热疗的情况下采样皮肤温度。事实证明,该系统能够通过无线数据传输监测皮肤温度,具有比最先进设备更高的空间分辨率。本文介绍了R-TMS的物理原理、设计和实验,以验证所提出的方法,并从电磁角度评估其可行性。
{"title":"Epidermal RFID-Based Thermal Monitoring Sheet (R-TMS) for Microwave Hyperthermia","authors":"Francesco Lestini;Nicoletta Panunzio;Gaetano Marrocco;Cecilia Occhiuzzi","doi":"10.1109/JERM.2023.3299525","DOIUrl":"10.1109/JERM.2023.3299525","url":null,"abstract":"Hyperthermia is an anti-cancer treatment that exploits the interaction between high-power electromagnetic fields and restricted regions of human tissues releasing a great amount of power to locally increase tissues temperature. Due to the high power, dangerous hot-spots may occur on the skin so that continuous monitoring of superficial temperature distribution is required. Thermal Monitoring Sheets (TMSs), which are grids of several wired temperature sensors, are currently used in clinical practice; however, they have some limitations in terms of poor spatial resolution, thermal conduction errors, and complex application procedures. Epidermal electronics associated with passive Ultra High Frequency (UHF) Radio Frequency IDentification (RFID) sensing technology could represent an attractive alternative thanks to its wireless nature and limited invasiveness. In this framework, this article proposes an innovative TMS based on battery-less RFID sensors (R-TMS). It comprises a planar grid of circular loop antennas with temperature-sensing-oriented ICs that can sample skin temperature without interfering with hyperthermia treatment. The system proved capable of monitoring skin temperature via wireless data transmission with a higher spatial resolution that state-of-the-art devices. The physical rationale, the design, and the experimentation of the R-TMS are here presented to validate the proposed approach and evaluate its feasibility from the electromagnetic perspective.","PeriodicalId":29955,"journal":{"name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88397618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental Wireless Link and SAR Assessments of an Implantable PIFA for Biotelemetry in the 2.45 GHz Band 2.45GHz波段生物遥测用植入式PIFA的实验无线链路和SAR评估
IF 3.2 Q1 Physics and Astronomy Pub Date : 2023-07-28 DOI: 10.1109/JERM.2023.3294707
Muhammad Solihin Zulkefli;Kai Zhang;Mariella Sarestoniemi;Sami Myllymäki;William G. Whittow;Sen Yan;Ping Jack Soh
An experimental wireless link and specific absorption rate (SAR) assessment is presented in this work. A compact planar inverted-F antenna (PIFA) is designed and evaluated for biotelemetry application as an antenna at 2.45 GHz band. The proposed antenna provided a satisfactory bandwidth per unit volume using a two-layered stacked structure consisting of a high-frequency laminate and a low loss ceramic layer. The antenna was first co-designed inside several different types of phantom boxes to optimize its performance, considering computational resources. Next, a semisolid intestinal phantom model used in simulations were chosen to be fabricated for experimental evaluations. Evaluation results indicated a satisfactory antenna's operation from 2.13 to 2.81 GHz (bandwidth of 27.8%), with realized gains of −26.49 dBi when implanted at 45 mm inside the phantom. Next, measurements were performed on the antenna's communication link with a wearable antenna to study the effects its depth (from 10 to 45mm), indicating transmission coefficients of between −40 and −60 dB at 2.45 GHz. Finally, its SAR levels are evaluated experimentally using a commercial measurement system when implanted within the human tissue. Results indicated satisfactory level of 0.685 W/kg (averaged over 10 g of tissues) and is suitable for biotelemetry application.
本文介绍了一种实验性的无线链路和比吸收率(SAR)评估方法。设计并评估了一种紧凑型平面倒F天线(PIFA)作为2.45GHz频带的天线,用于生物遥测应用。所提出的天线使用由高频层压板和低损耗陶瓷层组成的双层堆叠结构,提供了令人满意的单位体积带宽。该天线最初是在几种不同类型的幻影盒内共同设计的,以优化其性能,同时考虑到计算资源。接下来,选择模拟中使用的半固体肠道体模模型进行实验评估。评估结果表明,天线在2.13至2.81 GHz(带宽27.8%)范围内的工作令人满意,当植入体模内部45 mm时,实现的增益为-26.49 dBi。接下来,对天线与可穿戴天线的通信链路进行了测量,以研究其深度(从10到45mm)的影响,表明2.45 GHz时的传输系数在−40到−60 dB之间。最后,当植入人体组织内时,使用商业测量系统对其SAR水平进行实验评估。结果表明0.685W/kg(平均超过10g组织)的令人满意的水平,并且适合生物遥测应用。
{"title":"Experimental Wireless Link and SAR Assessments of an Implantable PIFA for Biotelemetry in the 2.45 GHz Band","authors":"Muhammad Solihin Zulkefli;Kai Zhang;Mariella Sarestoniemi;Sami Myllymäki;William G. Whittow;Sen Yan;Ping Jack Soh","doi":"10.1109/JERM.2023.3294707","DOIUrl":"https://doi.org/10.1109/JERM.2023.3294707","url":null,"abstract":"An experimental wireless link and specific absorption rate (SAR) assessment is presented in this work. A compact planar inverted-F antenna (PIFA) is designed and evaluated for biotelemetry application as an antenna at 2.45 GHz band. The proposed antenna provided a satisfactory bandwidth per unit volume using a two-layered stacked structure consisting of a high-frequency laminate and a low loss ceramic layer. The antenna was first co-designed inside several different types of phantom boxes to optimize its performance, considering computational resources. Next, a semisolid intestinal phantom model used in simulations were chosen to be fabricated for experimental evaluations. Evaluation results indicated a satisfactory antenna's operation from 2.13 to 2.81 GHz (bandwidth of 27.8%), with realized gains of −26.49 dBi when implanted at 45 mm inside the phantom. Next, measurements were performed on the antenna's communication link with a wearable antenna to study the effects its depth (from 10 to 45mm), indicating transmission coefficients of between −40 and −60 dB at 2.45 GHz. Finally, its SAR levels are evaluated experimentally using a commercial measurement system when implanted within the human tissue. Results indicated satisfactory level of 0.685 W/kg (averaged over 10 g of tissues) and is suitable for biotelemetry application.","PeriodicalId":29955,"journal":{"name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50291935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Explainable Deep Learning Method for Microwave Head Stroke Localization 一种可解释的微波脑卒中定位深度学习方法
IF 3.2 Q1 Physics and Astronomy Pub Date : 2023-07-12 DOI: 10.1109/JERM.2023.3287681
Wei-chung Lai;Lei Guo;Konstanty Bialkowski;Alina Bialkowski
In this article, an explainable deep learning scheme is proposed to tackle microwave imaging for the task of multiple object localisation. Deep learning has been involved in solving microwave imaging tasks due to its strong pattern recognition capabilities. However, the lack of explainability of the model's predictions makes it infeasible to deploy deep learning models in practical applications such as stroke detection and localisation as the model is a black box, the confidence of the output is unknown as they cannot be verified. This article aims to alleviate this concern by applying the gradient-weighted class activation map (Grad-CAM), an explainable artificial intelligence technique, together with the Delay-Multiply-And-Sum (DMAS) algorithm to spatially explain the deep learning model. The Grad-CAM method highlights the important parts of the input signal for decision making and the important parts are mapped to the image domain to provide a more intuitive understanding of the model. This article concludes that the deep learning model learns from reliable information and provides outputs which have a physical basis.
在本文中,提出了一种可解释的深度学习方案来解决微波成像的多目标定位任务。由于其强大的模式识别能力,深度学习已被用于解决微波成像任务。然而,由于模型预测缺乏可解释性,因此在实际应用中部署深度学习模型是不可行的,例如中风检测和定位,因为模型是一个黑匣子,输出的置信度未知,因为它们无法验证。本文旨在通过应用梯度加权类激活图(Grad-CAM),一种可解释的人工智能技术,以及延迟乘和(DMAS)算法来在空间上解释深度学习模型,从而减轻这种担忧。Grad-CAM方法突出了输入信号中用于决策的重要部分,并将重要部分映射到图像域,以提供对模型更直观的理解。本文的结论是,深度学习模型从可靠的信息中学习,并提供具有物理基础的输出。
{"title":"An Explainable Deep Learning Method for Microwave Head Stroke Localization","authors":"Wei-chung Lai;Lei Guo;Konstanty Bialkowski;Alina Bialkowski","doi":"10.1109/JERM.2023.3287681","DOIUrl":"10.1109/JERM.2023.3287681","url":null,"abstract":"In this article, an explainable deep learning scheme is proposed to tackle microwave imaging for the task of multiple object localisation. Deep learning has been involved in solving microwave imaging tasks due to its strong pattern recognition capabilities. However, the lack of explainability of the model's predictions makes it infeasible to deploy deep learning models in practical applications such as stroke detection and localisation as the model is a black box, the confidence of the output is unknown as they cannot be verified. This article aims to alleviate this concern by applying the gradient-weighted class activation map (Grad-CAM), an explainable artificial intelligence technique, together with the Delay-Multiply-And-Sum (DMAS) algorithm to spatially explain the deep learning model. The Grad-CAM method highlights the important parts of the input signal for decision making and the important parts are mapped to the image domain to provide a more intuitive understanding of the model. This article concludes that the deep learning model learns from reliable information and provides outputs which have a physical basis.","PeriodicalId":29955,"journal":{"name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75084701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated Workflow for Evaluating Microwave and Multi-Modality Breast Images 评估微波和多模态乳腺图像的自动化工作流程
IF 3.2 Q1 Physics and Astronomy Pub Date : 2023-07-06 DOI: 10.1109/JERM.2023.3289767
Douglas J. Kurrant;Muhammad Omer;Elise C. Fear
The emergence and subsequent expansion of the field of medical microwave imaging has resulted in numerous approaches to image reconstruction. This includes microwave tomography, radar imaging, and more recently, multi-modality approaches. However, there is an absence of a standardized and widely accepted process that is proficient at extracting information from these images and employing this knowledge to conduct a thorough quantitative evaluation of images and regions within images. This shortcoming may interfere with a researcher's ability to make reliable and consistent inferences from experiments and to interpret results. Consequently, comparing the results of different research groups is difficult. This is becoming increasingly relevant due to the development of standardized test phantoms and the increase in clinical studies. To remedy this deficiency, an automated workflow has been developed with the objective to standardize the processing and analysis of images acquired from a range of modalities. Images are first segmented into regions dominated by a tissue type. Quantitative information extracted from these regions is used for analysis and by visualization tools for the qualitative interpretation of images. The effectiveness of the workflow is demonstrated with multiple examples that focus on quantifying changes to images due to enhancements of the reconstruction algorithm or perturbations of a parameter used by the reconstruction operator.
医学微波成像领域的出现和随后的扩展导致了许多图像重建方法。这包括微波断层扫描、雷达成像,以及最近的多模态方法。然而,缺乏一种标准化和广泛接受的过程,该过程擅长从这些图像中提取信息,并利用这些知识对图像和图像内的区域进行彻底的定量评估。这一缺点可能会干扰研究人员从实验中做出可靠和一致的推断以及解释结果的能力。因此,很难比较不同研究小组的结果。由于标准化测试模型的发展和临床研究的增加,这一点变得越来越重要。为了弥补这一不足,开发了一种自动化工作流程,目的是使从一系列模态获取的图像的处理和分析标准化。图像首先被分割成由组织类型主导的区域。从这些区域提取的定量信息用于分析,并由可视化工具用于图像的定性解释。该工作流程的有效性通过多个示例得到了证明,这些示例侧重于量化由于重建算法的增强或重建操作员使用的参数的扰动而导致的图像变化。
{"title":"Automated Workflow for Evaluating Microwave and Multi-Modality Breast Images","authors":"Douglas J. Kurrant;Muhammad Omer;Elise C. Fear","doi":"10.1109/JERM.2023.3289767","DOIUrl":"https://doi.org/10.1109/JERM.2023.3289767","url":null,"abstract":"The emergence and subsequent expansion of the field of medical microwave imaging has resulted in numerous approaches to image reconstruction. This includes microwave tomography, radar imaging, and more recently, multi-modality approaches. However, there is an absence of a standardized and widely accepted process that is proficient at extracting information from these images and employing this knowledge to conduct a thorough quantitative evaluation of images and regions within images. This shortcoming may interfere with a researcher's ability to make reliable and consistent inferences from experiments and to interpret results. Consequently, comparing the results of different research groups is difficult. This is becoming increasingly relevant due to the development of standardized test phantoms and the increase in clinical studies. To remedy this deficiency, an automated workflow has been developed with the objective to standardize the processing and analysis of images acquired from a range of modalities. Images are first segmented into regions dominated by a tissue type. Quantitative information extracted from these regions is used for analysis and by visualization tools for the qualitative interpretation of images. The effectiveness of the workflow is demonstrated with multiple examples that focus on quantifying changes to images due to enhancements of the reconstruction algorithm or perturbations of a parameter used by the reconstruction operator.","PeriodicalId":29955,"journal":{"name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50291936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility Analysis of Theranostic Magnetic Scaffolds for Microwave Monitoring of Hyperthermia Treatment of Bone Tumors 磁性支架用于骨肿瘤热疗微波监测的可行性分析
IF 3.2 Q1 Physics and Astronomy Pub Date : 2023-07-03 DOI: 10.1109/JERM.2023.3288741
Matteo Bruno Lodi;Nicola Curreli;Chiara Dachena;Alessandro Fedeli;Rosa Scapaticci;Andrea Randazzo;Matteo Pastorino;Alessandro Fanti
Magnetic biomaterials are multifunctional tools currently under investigation as theranostic platforms for biomedical applications. They can be implanted in bone tissue after bone cancer resection to perform local interstitial hyperthermia treatment. Given the requirements of high quality treatment, the hyperthermia therapy should be performed monitoring the system temperature, to avoid hot spots and control the treatment outcome. It is known that the magnetic properties of such implants vary with temperature. It is hypotesized that the treatment dynamic could be monitored using a microwave monitoring system. The variation of the electromagnetic properties of the biological tissues and the magnetic implant during the therapy would result in a different propagation of the microwave signal. This work investigates the feasibility of using microwaves to non-invasively monitor hyperthermia treatments with a simplified monodimensional propagation model. The forward problem is solved to identify the working frequencies, the matching medium properties and study several candidate materials. By using the numerical solutions from nonlinear and multiphysics simulations of the bone tumor hyperthermia treatment using magnetic scaffolds, the microwave signal propagation dynamic is studied. From our feasibility analysis, we found that it is possible to correlate the average tumor temperature with significant ($sim$20 dB) variations in the transmission coefficient during a typical interstitial hyperthermia session using magnetic scaffolds. Our work brings together, for the first time, the electromagnetic material properties, the physio-pathology and physics of the hyperthermia treatment and the microwave propagation problem, thus paving the route for the development of an innovative theranostic system.
磁性生物材料是一种多功能工具,目前正在研究作为生物医学应用的治疗平台。它们可以在骨癌切除后植入骨组织中进行局部间质热疗。鉴于高质量治疗的要求,热疗应监测系统温度,避免出现热点,控制治疗结果。众所周知,这种植入物的磁性随温度而变化。假设可以用微波监测系统监测处理动态。在治疗过程中,生物组织和磁性植入物的电磁特性会发生变化,导致微波信号的传播方式不同。本研究利用简化的一维传播模型,探讨微波无创监测热疗的可行性。解决了正演问题,确定了工作频率,匹配介质性质,并研究了几种候选材料。利用磁性支架骨肿瘤热疗过程的非线性多物理场模拟数值解,研究了微波信号的传播动态。从我们的可行性分析中,我们发现在使用磁性支架的典型间质热疗过程中,肿瘤平均温度与透射系数的显著变化($sim$20 dB)是可能相关的。我们的工作首次将电磁材料特性、热疗治疗的生理病理学和物理学以及微波传播问题结合在一起,从而为开发创新的治疗系统铺平了道路。
{"title":"Feasibility Analysis of Theranostic Magnetic Scaffolds for Microwave Monitoring of Hyperthermia Treatment of Bone Tumors","authors":"Matteo Bruno Lodi;Nicola Curreli;Chiara Dachena;Alessandro Fedeli;Rosa Scapaticci;Andrea Randazzo;Matteo Pastorino;Alessandro Fanti","doi":"10.1109/JERM.2023.3288741","DOIUrl":"10.1109/JERM.2023.3288741","url":null,"abstract":"Magnetic biomaterials are multifunctional tools currently under investigation as theranostic platforms for biomedical applications. They can be implanted in bone tissue after bone cancer resection to perform local interstitial hyperthermia treatment. Given the requirements of high quality treatment, the hyperthermia therapy should be performed monitoring the system temperature, to avoid hot spots and control the treatment outcome. It is known that the magnetic properties of such implants vary with temperature. It is hypotesized that the treatment dynamic could be monitored using a microwave monitoring system. The variation of the electromagnetic properties of the biological tissues and the magnetic implant during the therapy would result in a different propagation of the microwave signal. This work investigates the feasibility of using microwaves to non-invasively monitor hyperthermia treatments with a simplified monodimensional propagation model. The forward problem is solved to identify the working frequencies, the matching medium properties and study several candidate materials. By using the numerical solutions from nonlinear and multiphysics simulations of the bone tumor hyperthermia treatment using magnetic scaffolds, the microwave signal propagation dynamic is studied. From our feasibility analysis, we found that it is possible to correlate the average tumor temperature with significant (\u0000<inline-formula><tex-math>$sim$</tex-math></inline-formula>\u000020 dB) variations in the transmission coefficient during a typical interstitial hyperthermia session using magnetic scaffolds. Our work brings together, for the first time, the electromagnetic material properties, the physio-pathology and physics of the hyperthermia treatment and the microwave propagation problem, thus paving the route for the development of an innovative theranostic system.","PeriodicalId":29955,"journal":{"name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=10172102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77804967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Influence of Intrinsic Water and Ion Permeation on the Dielectric Properties of Parylene C Films 本征水和离子渗透对聚对二甲苯C薄膜介电性能的影响
IF 3.2 Q1 Physics and Astronomy Pub Date : 2023-07-03 DOI: 10.1109/JERM.2023.3285049
Jacob T. Pawlik;Nikolas D. Barrera;Eugene J. Yoon;James C. Booth;Christian J. Long;Nathan D. Orloff;Ellis Meng;Angela C. Stelson
Parylene C is a widely used dielectric barrier in implantable medical devices because it conforms well to surfaces and insulates against biological environments. However, multiple studies have shown that moisture can intrude into Parylene C films through defects and intrinsic diffusion, leading to delamination and device failure. While many studies have tested device integrity in vitro, few have isolated the influence of specific degradation mechanisms on device failure. Here, we use a broadband impedance technique called Microwave Microfluidic Spectroscopy (MMS) to measure fluid permeation in targeted regions of Parylene C films that are free of defects and have optimal adhesion to the substrate. We found no changes in the broadband S-parameters from 100 MHz–110 GHz for Parylene C coated coplanar waveguides soaked in water or phosphate buffered saline at 20 °C or 37 °C for two months. Furthermore, there was no delamination induced by fluid soaking. Our study helps to clear debate about the influence of water and ion diffusion on Parylene C device lifetime and inform better fabrication of Parylene C coatings for implantable devices.
聚对二甲苯C是一种广泛应用于植入式医疗器械的介电屏障,因为它与表面很好地吻合,并且与生物环境绝缘。然而,多项研究表明,水分可以通过缺陷和本征扩散侵入聚对二甲苯薄膜,导致分层和器件失效。虽然许多研究在体外测试了设备的完整性,但很少有研究分离出特定降解机制对设备故障的影响。在这里,我们使用一种称为微波微流体光谱(MMS)的宽带阻抗技术来测量无缺陷且与衬底具有最佳粘附性的聚对二甲苯薄膜目标区域的流体渗透率。我们发现,在20°C或37°C的水或磷酸盐缓冲盐水中浸泡两个月的聚对二甲苯涂层共面波导的宽带s参数在100 MHz-110 GHz范围内没有变化。此外,液体浸泡没有引起分层。我们的研究有助于澄清关于水和离子扩散对聚对二甲苯器件寿命影响的争论,并为更好地制造用于植入器件的聚对二甲苯涂层提供信息。
{"title":"The Influence of Intrinsic Water and Ion Permeation on the Dielectric Properties of Parylene C Films","authors":"Jacob T. Pawlik;Nikolas D. Barrera;Eugene J. Yoon;James C. Booth;Christian J. Long;Nathan D. Orloff;Ellis Meng;Angela C. Stelson","doi":"10.1109/JERM.2023.3285049","DOIUrl":"10.1109/JERM.2023.3285049","url":null,"abstract":"Parylene C is a widely used dielectric barrier in implantable medical devices because it conforms well to surfaces and insulates against biological environments. However, multiple studies have shown that moisture can intrude into Parylene C films through defects and intrinsic diffusion, leading to delamination and device failure. While many studies have tested device integrity in vitro, few have isolated the influence of specific degradation mechanisms on device failure. Here, we use a broadband impedance technique called Microwave Microfluidic Spectroscopy (MMS) to measure fluid permeation in targeted regions of Parylene C films that are free of defects and have optimal adhesion to the substrate. We found no changes in the broadband S-parameters from 100 MHz–110 GHz for Parylene C coated coplanar waveguides soaked in water or phosphate buffered saline at 20 °C or 37 °C for two months. Furthermore, there was no delamination induced by fluid soaking. Our study helps to clear debate about the influence of water and ion diffusion on Parylene C device lifetime and inform better fabrication of Parylene C coatings for implantable devices.","PeriodicalId":29955,"journal":{"name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72592318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Efficient Circuit for Pulsed Magnetic Neural Stimulation 一种有效的脉冲磁神经刺激电路
IF 3.2 Q1 Physics and Astronomy Pub Date : 2023-06-30 DOI: 10.1109/JERM.2023.3289155
Peter M. Asbeck;Sravya Alluri;Vincent Leung;Shaghayegh Abbasi;Milan T. Makale
Pulse stimulation of peripheral nerves (PNS) is extensively used in the diagnosis of nerve abnormalities and can be applied for pain mitigation and to promote nerve regrowth. Nerve stimulation via magnetic pulses can provide advantages over conventional electrical stimulation; it obviates the need for electrode contact with the skin and is typically less painful. This work contributes to the development of compact and portable systems for magnetic PNS (M-PNS). To date, M-PNS has largely employed pulse generation systems developed for repetitive transcranial magnetic stimulation (rTMS). A new circuit is demonstrated to generate pulsed magnetic fields that increases induced electric (E) field intensities over those attainable in conventional rTMS systems. The resultant E-field has a shortened duration. The required external voltage input is below 300 V. A compact circuit implementation produced peak E-fields of 280 V/m at 1.5 cm distance from the magnetic coil, in 23 μs pulses (while 70-280 μs pulses are typically used for rTMS). Although threshold E fields for neural excitation increase with shorter pulse widths, neural excitation is demonstrated in human subjects via ulnar nerve stimulation and electromyography. This circuit technique may facilitate greater feasibility and flexibility in the design of miniaturized and portable PNS medical devices.
外周神经脉冲刺激(PNS)广泛用于神经异常的诊断,可用于减轻疼痛和促进神经再生。通过磁脉冲的神经刺激可以提供优于传统电刺激的优点;它消除了电极与皮肤接触的需要,并且通常不那么痛苦。这项工作有助于开发用于磁性PNS(M-PNS)的紧凑和便携式系统。到目前为止,M-PNS在很大程度上采用了为重复经颅磁刺激(rTMS)开发的脉冲产生系统。一种新的电路被证明可以产生脉冲磁场,该脉冲磁场比传统rTMS系统中可获得的感应电场强度增加。由此产生的E字段具有缩短的持续时间。所需的外部电压输入低于300 V。紧凑的电路实现在距离磁线圈1.5厘米处产生峰值电场280 V/m,脉冲为23μs(而70-280μs脉冲通常用于rTMS)。尽管神经兴奋的阈值E场随着脉冲宽度的缩短而增加,但通过尺神经刺激和肌电图在人类受试者中显示了神经兴奋。这种电路技术可以促进在小型化和便携式PNS医疗设备的设计中具有更大的可行性和灵活性。
{"title":"An Efficient Circuit for Pulsed Magnetic Neural Stimulation","authors":"Peter M. Asbeck;Sravya Alluri;Vincent Leung;Shaghayegh Abbasi;Milan T. Makale","doi":"10.1109/JERM.2023.3289155","DOIUrl":"https://doi.org/10.1109/JERM.2023.3289155","url":null,"abstract":"Pulse stimulation of peripheral nerves (PNS) is extensively used in the diagnosis of nerve abnormalities and can be applied for pain mitigation and to promote nerve regrowth. Nerve stimulation via magnetic pulses can provide advantages over conventional electrical stimulation; it obviates the need for electrode contact with the skin and is typically less painful. This work contributes to the development of compact and portable systems for magnetic PNS (M-PNS). To date, M-PNS has largely employed pulse generation systems developed for repetitive transcranial magnetic stimulation (rTMS). A new circuit is demonstrated to generate pulsed magnetic fields that increases induced electric (E) field intensities over those attainable in conventional rTMS systems. The resultant E-field has a shortened duration. The required external voltage input is below 300 V. A compact circuit implementation produced peak E-fields of 280 V/m at 1.5 cm distance from the magnetic coil, in 23 μs pulses (while 70-280 μs pulses are typically used for rTMS). Although threshold E fields for neural excitation increase with shorter pulse widths, neural excitation is demonstrated in human subjects via ulnar nerve stimulation and electromyography. This circuit technique may facilitate greater feasibility and flexibility in the design of miniaturized and portable PNS medical devices.","PeriodicalId":29955,"journal":{"name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50404732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Skull Phase Compensation Combined Full Waveform Inversion for Transcranial Thermoacoustic Imaging With a Real Human Skull Validated 颅骨相位补偿联合全波形反演经颅热声成像与真人颅骨验证
IF 3.2 Q1 Physics and Astronomy Pub Date : 2023-06-08 DOI: 10.1109/JERM.2023.3281057
Shuang-Li Liu;Xin Shang;Wan-Ting Peng;Wei-Jia Wan;Jin-Bao Zhang
In recent years, cerebrovascular disease has become one of the leading causes of death among Chinese residents. Early detection of brain disease is, therefore, of great significance in reducing the risks to life and health. Thermoacoustic imaging has emerged as a promising technique for detecting brain disease, which meets the requirements of high penetration depth and real-time imaging in transcranial imaging. However, the acoustic characteristics of the skull can significantly impact the propagation of thermoacoustic signals, leading to attenuation and apparent phase difference, resulting in poor quality of reconstructed image and location deviation of symptom points. In this study, a skull phase compensated method combined full waveform inversion for transcranial thermoacoustic imaging is proposed. The adaptive positioning of skull is realized firstly by improving the W-AIC algorithm in thermoacoustic imaging to solve the phase difference problem and FWI technology is applied for reconstructing the intracranial SoS distribution. Numerical simulation of a human brain model and actual human skull experiments further verify the feasibility of this method in improving the quality of thermoacoustic images, thereby providing a reliable theoretical basis for the clinical application of transcranial thermoacoustic imaging.
近年来,脑血管疾病已成为我国居民死亡的主要原因之一。因此,早期发现脑部疾病对于减少生命和健康风险具有重要意义。热声成像满足经颅成像对高穿透深度和实时成像的要求,是一种很有前途的脑部疾病检测技术。然而,颅骨的声学特性会显著影响热声信号的传播,导致衰减和明显的相位差,从而导致重建图像质量差和症状点位置偏差。本研究提出了一种结合全波形反演的颅骨相位补偿方法用于经颅热声成像。首先对热声成像中的W-AIC算法进行改进,解决相位差问题,实现颅骨自适应定位,并应用FWI技术重建颅内SoS分布。人脑模型的数值模拟和实际人头骨实验进一步验证了该方法在提高热声成像质量方面的可行性,从而为经颅热声成像的临床应用提供了可靠的理论依据。
{"title":"Skull Phase Compensation Combined Full Waveform Inversion for Transcranial Thermoacoustic Imaging With a Real Human Skull Validated","authors":"Shuang-Li Liu;Xin Shang;Wan-Ting Peng;Wei-Jia Wan;Jin-Bao Zhang","doi":"10.1109/JERM.2023.3281057","DOIUrl":"10.1109/JERM.2023.3281057","url":null,"abstract":"In recent years, cerebrovascular disease has become one of the leading causes of death among Chinese residents. Early detection of brain disease is, therefore, of great significance in reducing the risks to life and health. Thermoacoustic imaging has emerged as a promising technique for detecting brain disease, which meets the requirements of high penetration depth and real-time imaging in transcranial imaging. However, the acoustic characteristics of the skull can significantly impact the propagation of thermoacoustic signals, leading to attenuation and apparent phase difference, resulting in poor quality of reconstructed image and location deviation of symptom points. In this study, a skull phase compensated method combined full waveform inversion for transcranial thermoacoustic imaging is proposed. The adaptive positioning of skull is realized firstly by improving the W-AIC algorithm in thermoacoustic imaging to solve the phase difference problem and FWI technology is applied for reconstructing the intracranial SoS distribution. Numerical simulation of a human brain model and actual human skull experiments further verify the feasibility of this method in improving the quality of thermoacoustic images, thereby providing a reliable theoretical basis for the clinical application of transcranial thermoacoustic imaging.","PeriodicalId":29955,"journal":{"name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75290361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Tuned Microwave Resonant Sensor for Skin Cancerous Tumor Diagnosis 一种用于皮肤癌诊断的调谐微波共振传感器
IF 3.2 Q1 Physics and Astronomy Pub Date : 2023-06-07 DOI: 10.1109/JERM.2023.3281726
Sen Bing;Khengdauliu Chawang;J.-C. Chiao
In this work, a planar microwave sensor based on a flexible polyimide substrate has been developed to distinguish if a skin lesion is malignant or benign. The sensor is a tuned loop resonator operating in the industrial, scientific, and medical (ISM) band at 2.465 GHz, providing a localized high-intensity electric field that penetrates into tissues with sufficient spatial and spectral resolutions. The loop resonator with a radius of 5.4 mm was tuned by a concentric metal pad to the desired resonant frequency with a sufficiently high quality factor of 98.7 and a reflection coefficient of $-$63.98 dB. The sensor is based on the detection of electromagnetic resonance change and sequential frequency shift that is susceptible to the dielectric property difference between cancerous and benign tissues. Basal Cell Carcinoma (BCC) and Seborrheic Keratosis (SK), the most commonly found malignant and benign skin lesions with close visual similarities, were selected to demonstrate the sensing concept. Tissue-mimicking materials were fabricated to have similar dielectric properties to those of healthy skin, SK, and BCC tissues in the literature. Simulations and measurements were conducted. Significant frequency shifts of 759 MHz and 415 MHz were observed between BCC and SK phantoms in simulations and measurements, respectively, when the size of the tumor phantom was a cuboid of 12 mm × 12 mm × 4 mm underneath and among healthy skin. Simulations were conducted for different cuboid side lengths from 2 to 16 mm while the thickness remained at 4 mm. Malignant lesions could be distinguished with a cuboid side length as small as 2 mm. Corresponding measurements for cuboid side lengths of 6, 8, 10, and 12 mm were conducted and matched the trend well with the simulation results. The promising results in simulations and measurements validate the sensing principle, showing great potential for skin cancer detection in a noninvasive, efficient, and lower-cost way.
在这项工作中,基于柔性聚酰亚胺衬底的平面微波传感器已经开发出来,以区分皮肤病变是恶性还是良性。该传感器是一个调谐环路谐振器,工作在2.465 GHz的工业、科学和医疗(ISM)频段,提供局部高强度电场,穿透组织,具有足够的空间和光谱分辨率。环形谐振器的半径为5.4 mm,通过同心金属衬垫调谐到所需的谐振频率,质量因子为98.7,反射系数为$-$63.98 dB。该传感器是基于检测易受癌组织和良性组织介电特性差异影响的电磁共振变化和顺序频移。基底细胞癌(BCC)和脂溢性角化病(SK)是最常见的恶性和良性皮肤病变,具有密切的视觉相似性,被选择来证明感知概念。在文献中,组织模拟材料被制造成具有与健康皮肤、SK和BCC组织相似的介电特性。进行了模拟和测量。在模拟和测量中,当肿瘤幻影在健康皮肤下为12 mm × 12 mm × 4 mm的长方体时,在BCC和SK幻影之间分别观察到759 MHz和415 MHz的显著频移。在厚度保持在4 mm的情况下,对2 ~ 16 mm的不同长方体边长进行了模拟。恶性病变可以通过长至2mm的长方体边长来区分。对长方体边长6、8、10和12 mm进行了相应的测量,结果与仿真结果吻合较好。仿真和测量结果验证了传感原理,显示出以无创、高效和低成本的方式进行皮肤癌检测的巨大潜力。
{"title":"A Tuned Microwave Resonant Sensor for Skin Cancerous Tumor Diagnosis","authors":"Sen Bing;Khengdauliu Chawang;J.-C. Chiao","doi":"10.1109/JERM.2023.3281726","DOIUrl":"10.1109/JERM.2023.3281726","url":null,"abstract":"In this work, a planar microwave sensor based on a flexible polyimide substrate has been developed to distinguish if a skin lesion is malignant or benign. The sensor is a tuned loop resonator operating in the industrial, scientific, and medical (ISM) band at 2.465 GHz, providing a localized high-intensity electric field that penetrates into tissues with sufficient spatial and spectral resolutions. The loop resonator with a radius of 5.4 mm was tuned by a concentric metal pad to the desired resonant frequency with a sufficiently high quality factor of 98.7 and a reflection coefficient of \u0000<inline-formula><tex-math>$-$</tex-math></inline-formula>\u000063.98 dB. The sensor is based on the detection of electromagnetic resonance change and sequential frequency shift that is susceptible to the dielectric property difference between cancerous and benign tissues. Basal Cell Carcinoma (BCC) and Seborrheic Keratosis (SK), the most commonly found malignant and benign skin lesions with close visual similarities, were selected to demonstrate the sensing concept. Tissue-mimicking materials were fabricated to have similar dielectric properties to those of healthy skin, SK, and BCC tissues in the literature. Simulations and measurements were conducted. Significant frequency shifts of 759 MHz and 415 MHz were observed between BCC and SK phantoms in simulations and measurements, respectively, when the size of the tumor phantom was a cuboid of 12 mm × 12 mm × 4 mm underneath and among healthy skin. Simulations were conducted for different cuboid side lengths from 2 to 16 mm while the thickness remained at 4 mm. Malignant lesions could be distinguished with a cuboid side length as small as 2 mm. Corresponding measurements for cuboid side lengths of 6, 8, 10, and 12 mm were conducted and matched the trend well with the simulation results. The promising results in simulations and measurements validate the sensing principle, showing great potential for skin cancer detection in a noninvasive, efficient, and lower-cost way.","PeriodicalId":29955,"journal":{"name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2023-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79343105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1