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Design and Evaluation of an Applicator for Magnetopriming Treatments 一种用于磁引发治疗的应用器的设计与评价
IF 3.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-04-27 DOI: 10.1109/JERM.2023.3267659
Gaetano Chirico;Claudio D'Elia;Nicola D'Ambrosio;Rita Massa
Seed priming is a physiological seed enhancement method for overcoming poor and erratic seed germination in many crop and flowering plants. Magnetopriming is a pre-sowing seed treatment with magnetic field that appears as a promising method to improve seed performances. This paper presents a cost-efficient design and optimization of an exposure system for magnetopriming treatments. The proposed static magnetic field applicator is modelled and designed with the aid of commercial software. The prototype is realized and tested based on the best set of geometry parameters for optimum performance, in terms of strength and high homogeneity of the magnetic flux density in the Region of Interest. Both analytical and measurement results are found to be in good agreement with the simulated results. The system is low cost, environmentally friendly and easy to operate. It allows seed treatments at different strengths with high homogeneity within the samples. In this way, the treatments can be carried out following good practice requirements strongly recommended for a high quality bioelectromagnetic research to assure reliability and reproducibility of the experiments.
种子引发是一种生理种子增强方法,用于克服许多作物和开花植物种子发芽不良和不稳定的问题。磁引发是一种利用磁场进行种子预处理的方法,是提高种子性能的一种很有前途的方法。本文介绍了一种用于磁启动处理的曝光系统的成本效益设计和优化。所提出的静态磁场施加器是在商业软件的帮助下建模和设计的。原型是基于最佳几何参数集实现和测试的,以获得最佳性能,即感兴趣区域内磁通密度的强度和高均匀性。分析和测量结果与模拟结果吻合良好。该系统成本低,环境友好,易于操作。它允许以不同的强度进行种子处理,并在样品中具有高度的均匀性。通过这种方式,可以按照高质量生物电磁研究强烈建议的良好实践要求进行治疗,以确保实验的可靠性和再现性。
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引用次数: 0
Temperature-Induced Contrast Enhancement for Radar-Based Breast Tumor Detection at K-Band Using Tissue Mimicking Phantoms 利用组织模拟Phantoms在K波段进行基于雷达的乳腺肿瘤检测的温度诱导对比度增强
IF 3.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-04-18 DOI: 10.1109/JERM.2023.3265510
Jochen Moll;Teresa Slanina;Jonathan Stindl;Thomas Maetz;Duy Hai Nguyen;Viktor Krozer
Conventional approaches for microwave breast tumor detection are limited by the imaging resolution due to the low operating frequency. The objective of this work is to provide a proof of concept for radar-based detection of breast tumors in K-band using the temperature-dependent permittivity of the tissue for contrast enhancement. The innovation of this work is given by i) investigating higher microwave frequencies for breast cancer diagnostics and improved resolution; ii) exploiting variations in tissue temperature as a non-invasive approach for contrast-induced radar imaging eliminating the need for contrast agents such as nanoparticles; iii) using a well-defined setup with the breast compressed similar to mammography; iv) eliminating the need for coupling liquid through the usage of ultra-wideband bow-tie antennas operating from 16.55 to 40 GHz for a reflection coefficient lower than −10 dB; v) validating the experimental findings through numerical modelling. The experimental setup in this work consists of a single-pixel transmission setup with the antennas placed in a 3D printed container. Two different tissue mimicking phantoms have been studied that both model the temperature-dependent permittivity of biological tissue. The first phantom represents homogeneous fatty tissue properties and the second phantom simulates fatty tissue with a tumor inclusion. A uniform phantom warming is realized through a water bath combined with a continuous monitoring of the phantoms temperature. We show that a homogeneous phantom without tumor can be distinguished from a heterogeneous phantom with tumor in the temperature range of 28 $^circ$C to 38 $^circ$C.
用于微波乳腺肿瘤检测的常规方法由于低操作频率而受到成像分辨率的限制。这项工作的目的是利用组织的温度相关介电常数来增强对比度,为基于雷达的K波段乳腺肿瘤检测提供概念验证。这项工作的创新在于:i)研究用于乳腺癌症诊断的更高微波频率和提高的分辨率;ii)利用组织温度的变化作为对比度诱导的雷达成像的非侵入性方法,消除了对造影剂例如纳米颗粒的需要;iii)使用明确定义的设置,其中乳房被压缩,类似于乳房X光照相术;iv)通过使用从16.55到40GHz操作的超宽带蝴蝶结天线来消除对耦合液体的需要,反射系数低于−10dB;v) 通过数值模拟验证了实验结果。这项工作中的实验装置包括一个单像素传输装置,天线放置在3D打印的容器中。已经研究了两种不同的组织模拟体模,它们都对生物组织的温度相关介电常数进行了建模。第一个体模代表均匀的脂肪组织特性,第二个体模模拟含有肿瘤的脂肪组织。通过水浴结合对幻影温度的连续监测来实现均匀的幻影加热。我们发现,在28$^circ$C到38$^circ$C的温度范围内,没有肿瘤的同质体模可以与有肿瘤的异质体模区分开来。
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引用次数: 0
Electrophoretic Transport Through Fibrocartilage Driven by Square and Sawtooth Pulses With Decreased Joule Heating 方脉冲和锯齿脉冲驱动的纤维软骨电泳输运
IF 3.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-04-11 DOI: 10.1109/JERM.2023.3264116
Prince M. Atsu;Zachary Nicolella;Maya Webb;Nicholas Brady;Eunice Nepomuceno;Connor Mowen;Gary L. Thompson
Measurement of molecular transport through tissues can be performed using gel electrophoresis techniques but is subject to substantial changes of temperature over the course of an experiment due to conversion of electrical to thermal energy. The objective of this study is to mitigate thermal generation and accumulation while determining the electrophoretic mobility of charged molecules within annulus fibrosus cartilage tissue. By using electrical pulses as compared to direct current (DC), less total energy is input and more heat can dissipate in a given amount of time. Temperature measurements confirm that use of DC leads to higher rates of temperature change during electrophoresis, with Joule heating responsible for the thermal rise. The measured electrophoretic mobilities of two small, charged dye molecules are found to be similar among DC, square and sawtooth pulsed electrophoresis. One significant difference occurs between square and sawtooth pulses for the dye that interacts less with the cartilage tissue. Results herein suggest that accurate measurements with reduced temperature changes of thermally-sensitive tissues can be made using pulsed electrophoresis, which can lead to a better understanding of molecular transport under physiological conditions.
通过组织的分子传输的测量可以使用凝胶电泳技术进行,但由于电能转化为热能,在实验过程中温度会发生显著变化。本研究的目的是在确定纤维环软骨组织内带电分子的电泳迁移率的同时,减轻热的产生和积聚。与直流电(DC)相比,通过使用电脉冲,输入的总能量更少,并且在给定的时间内可以耗散更多的热量。温度测量证实,在电泳过程中,使用直流电会导致更高的温度变化率,焦耳加热会导致热上升。在直流、方形和锯齿脉冲电泳中,两个带电荷的小染料分子的电泳迁移率是相似的。对于与软骨组织相互作用较少的染料,在方形和锯齿形脉冲之间出现了一个显著的差异。本文的结果表明,使用脉冲电泳可以在降低热敏组织温度变化的情况下进行准确的测量,这可以更好地了解生理条件下的分子转运。
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引用次数: 0
IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology Publication Information IEEE医学和生物学中的电磁学、RF和微波杂志出版信息
IF 3.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-03-29 DOI: 10.1109/JERM.2023.3278151
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引用次数: 0
IEEE Journal of Electromagnetics, RF, and Microwaves in Medicine and Biology About this Journal IEEE医学和生物学中的电磁学、RF和微波杂志关于该杂志
IF 3.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-03-29 DOI: 10.1109/JERM.2023.3278155
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引用次数: 0
Semi-Implantable Wireless Power Transfer (WPT) System Integrated With On-Chip Power Management Unit (PMU) for Neuromodulation Application 用于神经调控应用的集成片上电源管理单元(PMU)的半可移植无线电源传输(WPT)系统
IF 3.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-03-27 DOI: 10.1109/JERM.2023.3256705
Dipon K. Biswas;Nabanita Saha;Arnav Kaul;Ifana Mahbub
Miniaturization of the neuromodulation system is important for non-invasive or sub-invasive optogenetic application. This work presents an optimized wireless power transfer (WPT) system integrated with an on-chip rectification circuitry and an off-chip stimulation circuitry for optogenetic stimulation of freely moving rodents. The proposed WPT system is built using parallel transmitter (TX) coils on printed circuit board (PCB) and wire-wound based receiver (RX) coil followed by a seven-stage voltage doubler and a low dropout regulator (LDO) circuit designed in 180 nm standard Complementary Metal Oxide Semiconductor (CMOS) process. A pulse stimulation is used to stimulate the neurons which is generated using a commercially available off-the-shelf (COTS) components based oscillator circuit. The intensity of the stimulation is controlled by using a COTS based LED driver circuit which controls the current through the $mu$LED. The total dimension of the RX coil is 8 mm × 3.4 mm. The maximum power transfer efficiency (PTE) of the proposed WPT system is $sim$35% and the power conversion efficiency (PCE) of the rectifier is 52%. The proposed system with reconfigurable stimulation frequency is suitable for exciting different brain areas for long-term health monitoring.
神经调控系统的小型化对于无创或亚创光遗传学应用是重要的。这项工作提出了一种优化的无线功率传输(WPT)系统,该系统集成了片上整流电路和片外刺激电路,用于自由移动的啮齿动物的光遗传学刺激。所提出的WPT系统是使用印刷电路板(PCB)上的并联发射器(TX)线圈和基于线绕的接收器(RX)线圈构建的,然后是在180nm标准互补金属氧化物半导体(CMOS)工艺中设计的七级倍压器和低压差调节器(LDO)电路。脉冲刺激用于刺激神经元,该神经元是使用基于商用现货(COTS)组件的振荡器电路产生的。通过使用基于COTS的LED驱动电路来控制刺激的强度,该驱动电路控制通过$mu$LED的电流。RX线圈的总尺寸为8 mm×3.4 mm。所提出的WPT系统的最大功率传输效率(PTE)为$35%,整流器的功率转换效率(PCE)为52%。所提出的具有可重构刺激频率的系统适用于刺激不同的大脑区域进行长期健康监测。
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引用次数: 0
Biomedical Radar System for Real-Time Contactless Fall Detection and Indoor Localization 实时非接触式跌倒检测和室内定位的生物医学雷达系统
IF 3.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-03-26 DOI: 10.1109/JERM.2023.3278473
Marco Mercuri;Ping Jack Soh;Pouya Mehrjouseresht;Felice Crupi;Dominique Schreurs
Fall incidents represent a major public health problem among elderly people. This resulted in a significant increase of the number of investigated systems aiming at detecting falls promptly. In this respect, in this work, a biomedical radar system is proposed for remote real-time fall detection and indoor localization. The system, consisting of a sensor and a base station, combines radar and wireless communication techniques, and uses a data processing technique to distinguish between fall events and normal movements. The classification, based on a Least-Square Support Vector Machine (LS -SVM), combined with the sliding window principle allows to perform fall detection in real-time. Moreover, it is capable to localize the subjects when the fall incident has been detected. The in-vivo validation showed a high success rate in detecting fall events, with a maximum delay of 340 ms. Moreover, a maximum mean absolute errors (MAE) of 3.8 cm and a maximum root-mean-square error (RMSE) of 7.5 cm were reported in measuring the subject's absolute distance.
跌倒事件是老年人的一个主要公共卫生问题。这导致了旨在及时检测跌倒的调查系统数量的显著增加。为此,本文提出了一种用于远程实时跌倒检测和室内定位的生物医学雷达系统。该系统由一个传感器和一个基站组成,结合了雷达和无线通信技术,并使用数据处理技术来区分坠落事件和正常运动。该分类基于最小二乘支持向量机(LS -SVM),结合滑动窗口原理,可以实时进行跌落检测。此外,当检测到坠落事件时,它能够定位受试者。体内验证显示,检测跌倒事件的成功率很高,最大延迟为340 ms。受试者绝对距离测量的最大平均绝对误差(MAE)为3.8 cm,最大均方根误差(RMSE)为7.5 cm。
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引用次数: 1
CHO and HepG2 Single-Cell Characterization With Planar Microchip Sensors up to 40 GHz 高达40GHz的平面微芯片传感器对CHO和HepG2单细胞的表征
IF 3.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-03-23 DOI: 10.1109/JERM.2023.3257480
Aleksandar Savić;Fabian Freiberger;Ralf Pörtner;Arne F. Jacob
The article deals with broadband microwave measurements performed on single dead and living biological cells from CHO and HepG2 cell lines. It reports results obtained with coplanar waveguide reflection and transmission type sensors, respectively. A straight-forward single liquid calibration procedure allows to extract the complex cell permittivity and compare it to that of the surrounding medium. The contrast is analyzed through $p$-value tests and in terms of the usual Cole-Cole parameters. The results demonstrate the distinguishability of the cell lines based on the permittivity.
本文对CHO和HepG2细胞系的单个死细胞和活细胞进行了宽带微波测量。报告了分别用共面波导反射型和透射型传感器获得的结果。直接的单液体校准程序可以提取复介电常数,并将其与周围介质的介电常数进行比较。对比是通过$p$-value测试和通常的Cole-Cole参数来分析的。结果证明了基于介电常数的单元线的可分辨性。
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引用次数: 0
Calibrating Double-Loop H-Field Probe Measurements of RF Coil Current for MRI 用于MRI的RF线圈电流双回路H场探针测量的校准
IF 3.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-03-17 DOI: 10.1109/JERM.2023.3274742
Wenjun Wang;Juan Diego Sánchez-Heredia;Tom Maurouard;Vitaliy Zhurbenko;Jan Henrik Ardenkjær-Larsen
Objective: Double-loop H-field probes are often used to measure current on loop antennae for magnetic resonance imaging (MRI). Loop crosstalk limits the dynamic range of direct measurements with such probes. The crosstalk can be removed by simple calibration. This work analyses the quantitative relation of a probe's calibrated ${S}_{21}$ with the RF coil current. Method: The analytical relation between RF coil current and calibrated ${S}_{21}$ measurements of a probe is established with the multi-port network theory, and verified by full-wave simulation and benchtop measurements. The effect of calibration is demonstrated by measuring the 1H trap frequency, the active detuning, and the preamplifier decoupling. Results: The calibration removes the effect of crosstalk in a probe and improves the lower bound of $| {{S}_{21}} |$. The calibrated ${S}_{21}$ is proportional to coil current. In the lower frequency range, the ratio of calibrated ${S}_{21}$ to coil current changes almost linearly with frequency. Impact: The calibration method improves the sensitivity of probe measurements and facilitates fine-tuning current-suppressing circuits like active detuning circuits, traps, preamplifier decoupling. The linear frequency dependency between ${S}_{21}$ measurements and coil current allows easy, fair comparison of coil current up to 128 MHz, and in some cases 298 MHz, helping build multi-nucleus coils.
目的:在磁共振成像(MRI)中,双环H场探针经常用于测量环形天线上的电流。环路串扰限制了使用这种探针进行直接测量的动态范围。串扰可以通过简单的校准来消除。这项工作分析了探针校准后的定量关系${S}_{21}$与RF线圈电流。方法:RF线圈电流与校准值之间的分析关系${S}_用多端口网络理论建立了探针的{21}$测量值,并通过全波模拟和台式测量进行了验证。通过测量1H陷波频率、有源失谐和前置放大器去耦,证明了校准的效果。结果:校准消除了探针中串扰的影响,并提高了$|的下限{{S}_{21}}|$。校准的${S}_{21}$与线圈电流成比例。在较低的频率范围内,校准的${S}_{21}$到线圈的电流几乎随频率线性变化。影响:校准方法提高了探针测量的灵敏度,并有助于微调电流抑制电路,如有源失谐电路、陷波器、前置放大器去耦。之间的线性频率相关性${S}_{21}$测量值和线圈电流允许对高达128 MHz的线圈电流进行简单、公平的比较,在某些情况下为298 MHz,有助于构建多核线圈。
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引用次数: 0
Flexible and Wearable Dual-Band Differential Extraoral Antenna for eTDS Applications 用于eTDS应用的灵活可佩戴双频差分口外天线
IF 3.2 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC Pub Date : 2023-03-09 DOI: 10.1109/JERM.2023.3271459
Sarita Ahlawat;Binod Kumar Kanaujia;Karumudi Rambabu
Wearable assistive devices are essential for performance monitoring and inferring the tongue gestures of disabled individuals in medical rehabilitation. In this paper, a flexible and wearable differential extraoral antenna is proposed with dual resonances (915 MHz and 2.4 GHz) in the Industrial, Scientific, and Medical (ISM) band for extraoral tongue drive system (eTDS) applications. The size of the fabricated prototype of the extraoral differential antenna is (0.135${{bm{lambda }}}_{bm{g}} , times, $0.065${{bm{lambda }}}_{bm{g}} , times , $0.002${{bm{lambda }}}_{bm{g}}$). The performance of the differential extraoral antenna is analysed using a realistic human head model. Further, the extraoral antenna is fabricated and experimentally validated its performance in the close vicinity of the artificial head model. The measured impedance bandwidth (≤ −10 dB) and peak gain values are 90 MHz and $ -$20.00 dBi, respectively, at 0.915 GHz; and 180 MHz and $ -!$ 12.87 dBi, respectively, at 2.4 GHz. The specific absorption rate (SAR) parameter values have also been analyzed for both the resonating frequencies over 1 g and 10 g of mass tissue through simulations. Further, the link budget was theoretically calculated based on these acceptable SAR values. The proposed antenna could communicate effectively by eliminating balun's additional impedance mismatch loss due to direct interfacing. Thus, the proposed extraoral differential antenna can establish an effective communication link for data and power transfer in the eTDS technology-based applications.
在医疗康复中,可穿戴辅助设备对于监测和推断残疾人的舌头手势至关重要。在本文中,提出了一种在工业、科学和医学(ISM)波段具有双谐振(915MHz和2.4GHz)的柔性可穿戴差分口外天线,用于口外舌驱动系统(eTDS)应用。所制造的口外差分天线原型的尺寸为(0.135${bm{lambda}}_{bm{g}},times,$0.065${。使用逼真的人头模型分析了差分口外天线的性能。此外,制作了口腔外天线,并在人工头部模型附近对其性能进行了实验验证。在0.915 GHz时,测得的阻抗带宽(≤−10 dB)和峰值增益值分别为90 MHz和$-$20.00 dBi;以及180 MHz和$-!$2.4GHz时分别为12.87dBi。还通过模拟分析了1g和10g质量组织上的共振频率的比吸收率(SAR)参数值。此外,链路预算在理论上是基于这些可接受的SAR值计算的。所提出的天线可以通过消除巴伦由于直接接口而产生的额外阻抗失配损失来有效地通信。因此,所提出的口外差分天线可以在基于eTDS技术的应用中为数据和功率传输建立有效的通信链路。
{"title":"Flexible and Wearable Dual-Band Differential Extraoral Antenna for eTDS Applications","authors":"Sarita Ahlawat;Binod Kumar Kanaujia;Karumudi Rambabu","doi":"10.1109/JERM.2023.3271459","DOIUrl":"https://doi.org/10.1109/JERM.2023.3271459","url":null,"abstract":"Wearable assistive devices are essential for performance monitoring and inferring the tongue gestures of disabled individuals in medical rehabilitation. In this paper, a flexible and wearable differential extraoral antenna is proposed with dual resonances (915 MHz and 2.4 GHz) in the Industrial, Scientific, and Medical (ISM) band for extraoral tongue drive system (eTDS) applications. The size of the fabricated prototype of the extraoral differential antenna is (0.135\u0000<inline-formula><tex-math>${{bm{lambda }}}_{bm{g}} , times, $</tex-math></inline-formula>\u00000.065\u0000<inline-formula><tex-math>${{bm{lambda }}}_{bm{g}} , times , $</tex-math></inline-formula>\u00000.002\u0000<inline-formula><tex-math>${{bm{lambda }}}_{bm{g}}$</tex-math></inline-formula>\u0000). The performance of the differential extraoral antenna is analysed using a realistic human head model. Further, the extraoral antenna is fabricated and experimentally validated its performance in the close vicinity of the artificial head model. The measured impedance bandwidth (≤ −10 dB) and peak gain values are 90 MHz and \u0000<inline-formula><tex-math>$ -$</tex-math></inline-formula>\u000020.00 dBi, respectively, at 0.915 GHz; and 180 MHz and \u0000<inline-formula><tex-math>$ -!$</tex-math></inline-formula>\u0000 12.87 dBi, respectively, at 2.4 GHz. The specific absorption rate (SAR) parameter values have also been analyzed for both the resonating frequencies over 1 g and 10 g of mass tissue through simulations. Further, the link budget was theoretically calculated based on these acceptable SAR values. The proposed antenna could communicate effectively by eliminating balun's additional impedance mismatch loss due to direct interfacing. Thus, the proposed extraoral differential antenna can establish an effective communication link for data and power transfer in the eTDS technology-based applications.","PeriodicalId":29955,"journal":{"name":"IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology","volume":"7 3","pages":"229-235"},"PeriodicalIF":3.2,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50404734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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IEEE Journal of Electromagnetics RF and Microwaves in Medicine and Biology
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