Pub Date : 2019-12-30DOI: 10.22435/hsji.v10i2.2440
S. N. Wahyuningrum, C. H. N. Priharsanti, S. Haryana, A. Ghozali
Background: Colorectal cancer is the world’s third most prevalent cancer, which 30% of cases are rectal cancer. Today, the effective diagnostic marker to accurately predict clinical outcome patients response to therapy did not found yet. Several research studies have indicated that miRNA potential as a prognostic biomarker. MiR-1243p plays as tumor suppressor that significantly down-regulated in some cancer and could radiosensitize human colorectal cancer cells. The aim of the study is to investigate the expression of miR-124-3p from rectal cancer patient who receive nCRT, and analyze its association with patient survival and others clinical parameters. Methods: This research involved 15 patients with histologically confirmed locally advanced rectal cancer (LARC) and received neoadjuvant chemotherapy/nCRT (radiotherapy 45-50 Gy with 1,8-2 Gy fractions over 1 to 3 months and chemotherapy 5-fluorouracil was administered orally). Patient blood (5 ml) were collected from peripheral venous before and after neoadjuvant chemoradiotherapy. miR-124-3p expression was performed using qRT-PCR and calculate using Livak method. Results: In this study, we found that increasing of miR-124 was significantly associate with high survival of rectal cancer patient (P = 0,003; OR =30, 95% CI = 1,41 – 638,15). Average of miR-124-3p expression increase significantly after nCRT (P<0,041, fold change before=1,14 ± 1,25; after=2,4 ± 1,84). Conclusion: Our finding suggests that miR-124-3p expression in blood serum was potential as biomarkers to predict rectal cancer patient survival after neoajduvant chemoradiotherapy. (Health Science Journal of Indonesia 2019;10(2):90-5)
{"title":"Increasing serum miR-124-3p expression is associated with the high survival rate of a rectal cancer patient after neoadjuvant chemoradiotherapy","authors":"S. N. Wahyuningrum, C. H. N. Priharsanti, S. Haryana, A. Ghozali","doi":"10.22435/hsji.v10i2.2440","DOIUrl":"https://doi.org/10.22435/hsji.v10i2.2440","url":null,"abstract":"Background: Colorectal cancer is the world’s third most prevalent cancer, which 30% of cases are rectal cancer. Today, the effective diagnostic marker to accurately predict clinical outcome patients response to therapy did not found yet. Several research studies have indicated that miRNA potential as a prognostic biomarker. MiR-1243p plays as tumor suppressor that significantly down-regulated in some cancer and could radiosensitize human colorectal cancer cells. The aim of the study is to investigate the expression of miR-124-3p from rectal cancer patient who receive nCRT, and analyze its association with patient survival and others clinical parameters. Methods: This research involved 15 patients with histologically confirmed locally advanced rectal cancer (LARC) and received neoadjuvant chemotherapy/nCRT (radiotherapy 45-50 Gy with 1,8-2 Gy fractions over 1 to 3 months and chemotherapy 5-fluorouracil was administered orally). Patient blood (5 ml) were collected from peripheral venous before and after neoadjuvant chemoradiotherapy. miR-124-3p expression was performed using qRT-PCR and calculate using Livak method. Results: In this study, we found that increasing of miR-124 was significantly associate with high survival of rectal cancer patient (P = 0,003; OR =30, 95% CI = 1,41 – 638,15). Average of miR-124-3p expression increase significantly after nCRT (P<0,041, fold change before=1,14 ± 1,25; after=2,4 ± 1,84). Conclusion: Our finding suggests that miR-124-3p expression in blood serum was potential as biomarkers to predict rectal cancer patient survival after neoajduvant chemoradiotherapy. (Health Science Journal of Indonesia 2019;10(2):90-5)","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":"10 1","pages":"90-95"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48128311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-30DOI: 10.22435/hsji.v12i2.2439
Elida Marpaung
Background: Kidd protein is red blood cell’s (RBC) major urea transporter. Albeit rare, the presence of antibodies against Kidd antigen may cause significant hemolytic transfusion reaction and hemolytic disease of the newborn. Yet, anti-Jka and anti-Jkb are rare to be discovered during antibody identification. This paper reported “bestmatched” transfusion practice in a patient with anti-Jka and anti-Jkb, where compatible PRC cannot be found, but transfusion is urgently needed. Case Presentation: A 36 years old, G4P3A0 female, came with continuous vaginal bleeding for the past one month before admission. USG revealed hydatidiform mole. She needed immediate curettage following correction of her anemia (Hb 8.3g/dL). After antibody screening procedure followed by antibody identification, we found a positive anti-Jka and anti-Jkb in her blood sample. At least 50 blood donors were tested for compatibility and none was a match. She was then transfused with the lowest agglutination blood available (level 2 of 5 levels), with a closed monitoring to anticipate the possibility of transfusion reaction development. Fever and pruritus transpired within 24 hours post transfusion and it resolved following diphenhydramine, dexamethasone, and paracetamol injection. Conclusion: Incompatible blood transfusion is the last option when compatible blood cannot be found. The development of transfusion reaction is inevitable, but it can be anticipated by closed monitoring. In restricted setting, blood transfusion with the lowest level of agglutination is acceptable when transfusion is imperative. In this case, the patient got optimal treatment in term of the medical surgery and transfusion response, which was shown by the significant increase of Hb level. Meanwhile, the adverse transfusion reaction was only mild, and could be treated with medicine. (Health Science Journal of Indonesia 2019;10(2):137-9)
{"title":"The safety of kidd-incompatible blood transfusion in a restricted setting: a case report","authors":"Elida Marpaung","doi":"10.22435/hsji.v12i2.2439","DOIUrl":"https://doi.org/10.22435/hsji.v12i2.2439","url":null,"abstract":"Background: Kidd protein is red blood cell’s (RBC) major urea transporter. Albeit rare, the presence of antibodies against Kidd antigen may cause significant hemolytic transfusion reaction and hemolytic disease of the newborn. Yet, anti-Jka and anti-Jkb are rare to be discovered during antibody identification. This paper reported “bestmatched” transfusion practice in a patient with anti-Jka and anti-Jkb, where compatible PRC cannot be found, but transfusion is urgently needed. Case Presentation: A 36 years old, G4P3A0 female, came with continuous vaginal bleeding for the past one month before admission. USG revealed hydatidiform mole. She needed immediate curettage following correction of her anemia (Hb 8.3g/dL). After antibody screening procedure followed by antibody identification, we found a positive anti-Jka and anti-Jkb in her blood sample. At least 50 blood donors were tested for compatibility and none was a match. She was then transfused with the lowest agglutination blood available (level 2 of 5 levels), with a closed monitoring to anticipate the possibility of transfusion reaction development. Fever and pruritus transpired within 24 hours post transfusion and it resolved following diphenhydramine, dexamethasone, and paracetamol injection. Conclusion: Incompatible blood transfusion is the last option when compatible blood cannot be found. The development of transfusion reaction is inevitable, but it can be anticipated by closed monitoring. In restricted setting, blood transfusion with the lowest level of agglutination is acceptable when transfusion is imperative. In this case, the patient got optimal treatment in term of the medical surgery and transfusion response, which was shown by the significant increase of Hb level. Meanwhile, the adverse transfusion reaction was only mild, and could be treated with medicine. (Health Science Journal of Indonesia 2019;10(2):137-9)","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":"10 1","pages":"137-139"},"PeriodicalIF":0.0,"publicationDate":"2019-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44438564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-29DOI: 10.22435/hsji.v12i2.2442
S. T. Widyaningtyas, Sofy Meilany, B. Bela
Background: Naturally Human Papillomavirus (HPV) type 16 L1 capsid protein can auto assemble to form Viral like particles (VLP). Concerning to vaccine development for HPV, VLP can be used for a variety of needs such as a vaccine, pseudovirion or SpyTag-Spycatcher. In this study, to obtain a vector expression that can be used in the production of HPV L1 protein, we cloned gene coding HPV 16 L1 protein into pQE80L a plasmid contains an expression system for prokaryote. Methods: The DNA coding HPV 16 L1 was inserted at BamHI and Hind III restriction sites of pQE80L plasmid. The recombinant plasmid containing the HPV L1 gene was confirmed using PCR colony and enzyme restriction. Further to ensure the recombinant HPV 16 L1 gene could be expressed in a prokaryote, the recombinant plasmid was transformed into bacteria Escherichia coli BL21 (DE3). The bacteria were induced with IPTG with various concentrations and various incubation time. Result: L1 recombinant protein, 56 kDa in weight, has successfully been expressed in prokaryote system. L1 recombinant protein can be purified using TalonR under denaturing conditions. Conclusion: L1 HPV 16 gene has been cloned into pQE80L and successfully expressed in prokaryote system. (Health Science Journal of Indonesia 2019;10(2):82-9)
{"title":"Cloning and expression of Human Papilloma virus type 16 L1 capsid protein in bacteria","authors":"S. T. Widyaningtyas, Sofy Meilany, B. Bela","doi":"10.22435/hsji.v12i2.2442","DOIUrl":"https://doi.org/10.22435/hsji.v12i2.2442","url":null,"abstract":"Background: Naturally Human Papillomavirus (HPV) type 16 L1 capsid protein can auto assemble to form Viral like particles (VLP). Concerning to vaccine development for HPV, VLP can be used for a variety of needs such as a vaccine, pseudovirion or SpyTag-Spycatcher. In this study, to obtain a vector expression that can be used in the production of HPV L1 protein, we cloned gene coding HPV 16 L1 protein into pQE80L a plasmid contains an expression system for prokaryote. Methods: The DNA coding HPV 16 L1 was inserted at BamHI and Hind III restriction sites of pQE80L plasmid. The recombinant plasmid containing the HPV L1 gene was confirmed using PCR colony and enzyme restriction. Further to ensure the recombinant HPV 16 L1 gene could be expressed in a prokaryote, the recombinant plasmid was transformed into bacteria Escherichia coli BL21 (DE3). The bacteria were induced with IPTG with various concentrations and various incubation time. Result: L1 recombinant protein, 56 kDa in weight, has successfully been expressed in prokaryote system. L1 recombinant protein can be purified using TalonR under denaturing conditions. Conclusion: L1 HPV 16 gene has been cloned into pQE80L and successfully expressed in prokaryote system. (Health Science Journal of Indonesia 2019;10(2):82-9)","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":"10 1","pages":"82-89"},"PeriodicalIF":0.0,"publicationDate":"2019-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49242247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-27DOI: 10.22435/hsji.v12i2.2448
N. Kusumawardani, Anissa Rizkianti, R. Mubasyiroh, P. P. Arfines, Tities Puspita
Background: Indonesia faces burden of nutrition related diseases as obesity is increasing while malnutrition still exists, including in adolescents. Research are limited in term of which specific demography and geography aspects in Indonesia while stronger strategic intervention to prevent obesity in adolescents is needed. Objective: This study aims to describe proportion of obesity in indifferent adolescents characteristic and eating behaviour in different regions. Method: This study used data from Indonesia 2015 Global School-based Health Survey developed by US CDC and WHO) with modification based on Indonesia specific. The analysis included 10,544 students covered national representative and three regions of school students (grade 7 to 12) in Indonesia. Statistical analysis used chi square and log regressions. Results: The logistic model showed adolescents students living in Java island has significantly higher risk of obesity (adjusted OR 2.1;95%CI 1.3-3.3) compare to their peers in outside Java and Sumatra Island, while behavior risk factors such as physical activity and dietary habit were not significantly associated with obesity. Conclusions: Issues disparity of obesity in adolescents occurred in the three main Islands in Indonesia, in different school grades and in those with different dietary risk behaviours. Intervention strategy to address adolescents obesity issues will need to be directed toward school-based settings with taking into account specific approaches for students in Sumatra and other main islands in Indonesia as well as specific for junior and senior high school. (Health Science Journal of Indonesia 2019;10(2):119-27)
{"title":"Adolescents school students in Java and Sumatra are in greater risk of obesity","authors":"N. Kusumawardani, Anissa Rizkianti, R. Mubasyiroh, P. P. Arfines, Tities Puspita","doi":"10.22435/hsji.v12i2.2448","DOIUrl":"https://doi.org/10.22435/hsji.v12i2.2448","url":null,"abstract":"Background: Indonesia faces burden of nutrition related diseases as obesity is increasing while malnutrition still exists, including in adolescents. Research are limited in term of which specific demography and geography aspects in Indonesia while stronger strategic intervention to prevent obesity in adolescents is needed. Objective: This study aims to describe proportion of obesity in indifferent adolescents characteristic and eating behaviour in different regions. Method: This study used data from Indonesia 2015 Global School-based Health Survey developed by US CDC and WHO) with modification based on Indonesia specific. The analysis included 10,544 students covered national representative and three regions of school students (grade 7 to 12) in Indonesia. Statistical analysis used chi square and log regressions. Results: The logistic model showed adolescents students living in Java island has significantly higher risk of obesity (adjusted OR 2.1;95%CI 1.3-3.3) compare to their peers in outside Java and Sumatra Island, while behavior risk factors such as physical activity and dietary habit were not significantly associated with obesity. Conclusions: Issues disparity of obesity in adolescents occurred in the three main Islands in Indonesia, in different school grades and in those with different dietary risk behaviours. Intervention strategy to address adolescents obesity issues will need to be directed toward school-based settings with taking into account specific approaches for students in Sumatra and other main islands in Indonesia as well as specific for junior and senior high school. (Health Science Journal of Indonesia 2019;10(2):119-27)","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":"10 1","pages":"119-127"},"PeriodicalIF":0.0,"publicationDate":"2019-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46105235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-26DOI: 10.22435/hsji.v12i2.2443
A. Ayusari, B. Wiboworini, Kusmadewi Eka Damayanti, D. Rahayu, Widardo Widardo, Yulia Lanti
Introduction: Studies showed some relation between fat consumption with body mass index and body composition. We conducted a study to investigate relationships between daily consumption of total fat, polyunsaturated fatty acid (PUFA) and total cholesterol with some nutritional parameters. Methods: This was cross-sectional study, with 102 subjects. The study was examined height, body weight, body mass index and body composition measurements using the Omron® HBF-212 body composition monitor. There was nutrisurvey 2007 to measure total fat, polyunsaturated fatty acid and total cholesterol consumption. We analyzed the correlation by using SpSS 21 (Spearman Rho) Results: Total fat consumption was not related to body mass index, total fat mass, and visceral fat mass. PUFA consumption was negatively associated with body mass index (p <0.014, -0.24) and total fat mass (p <0.001, -0.326), while consumption of total cholesterol was negatively associated with body mass index (p <0.019, -0.23), and total fat mass (p <0.001, -0.337) Conclusion: There was a relation between fat consumption with body mass index and body composition. (Health Science Journal of Indonesia 2019;10(2):128-31)
{"title":"Correlation between dietary fat consumption with body mass index and body composition (a preliminary study in community based)","authors":"A. Ayusari, B. Wiboworini, Kusmadewi Eka Damayanti, D. Rahayu, Widardo Widardo, Yulia Lanti","doi":"10.22435/hsji.v12i2.2443","DOIUrl":"https://doi.org/10.22435/hsji.v12i2.2443","url":null,"abstract":"Introduction: Studies showed some relation between fat consumption with body mass index and body composition. We conducted a study to investigate relationships between daily consumption of total fat, polyunsaturated fatty acid (PUFA) and total cholesterol with some nutritional parameters. Methods: This was cross-sectional study, with 102 subjects. The study was examined height, body weight, body mass index and body composition measurements using the Omron® HBF-212 body composition monitor. There was nutrisurvey 2007 to measure total fat, polyunsaturated fatty acid and total cholesterol consumption. We analyzed the correlation by using SpSS 21 (Spearman Rho) Results: Total fat consumption was not related to body mass index, total fat mass, and visceral fat mass. PUFA consumption was negatively associated with body mass index (p <0.014, -0.24) and total fat mass (p <0.001, -0.326), while consumption of total cholesterol was negatively associated with body mass index (p <0.019, -0.23), and total fat mass (p <0.001, -0.337) Conclusion: There was a relation between fat consumption with body mass index and body composition. (Health Science Journal of Indonesia 2019;10(2):128-31)","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":"10 1","pages":"128-131"},"PeriodicalIF":0.0,"publicationDate":"2019-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48501702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-26DOI: 10.22435/hsji.v10i1.1846
Nike Susanti, H. Herna
Latar belakang: Virus Polio Liar dapat menyebabkan kelumpuhan dan dapat dicegah dengan imunisasi. Untuk memonitor transmisi virus polio liar dilakukan surveilans Acute Flaccid Paralysis (AFP) dan investigasi laboratorium yang telah dimulai sejak tahun 1995 di Indonesia. Virus polio liar Indigenous terakhir ditemukan di Indonesia tahun 1995. Indonesia masih memiliki ancaman importasi virus polio liar dari negara endemis dan mutasi virus polio dari vaksin yang menyebakan kelumpuhan yang sama seperti virus polio liar. Artikel ini bertujuan untuk memberikan gambaran mengenai surveilans AFP berbasis laboratorium di Indonesia pada tahun 2003-2013 sehingga mengantarkan Indonesia sebagai negara bebas polio pada tahun 2014. Metode: Data yang dianalisis adalah data kasus AFP seluruh Indonesia periode tahun 2003-2013. Data didapat dari laboratorium jejaring laboratorium Polio di Jakarta, Bandung, Surabaya dan Sub Direktorat Surveilans, Direktorat Surveilans dan Karantina Kesehatan, Direktorat Jenderal Pencegahan dan Pengendalian Penyakit. Data di analisis menggunakan program Microsoft Excel. Hasil: Sebanyak 305 kasus AFP yang disebabkan oleh infeksi virus polio liar tipe 1 impor ditemukan pada tahun 2005 dan 2006. Terdapat 39 kasus AFP yang disebabkan cVDPV tipe 1 ditemukan di Pulau Madura pada tahun 2005. Virus polio liar tipe 1 hanya ditemukan di pulau Sumatera dan Jawa. Penyebaran Virus polio berhasil dihentikan pada tahun 2006 dan sudah tidak ditemukan lagi hingga tahun 2013. Kesimpulan: Surveilans AFP berbasis laboratorium yang baik berhasil memantau dan mendeteksi sirkulasi virus polio. Peningkatan kinerja surveillance AFP diperlukan untuk membuktikan terhentinya transmisi virus polio sehingga eradikasi polio secara global dapat diraih. Kata kunci: surveilans, laboratorium polio, Acute Flaccid Paralysis Abstract Background: Wild Poliovirus can cause flaccid paralysis and can be prevented by immunization. To monitor wild polio virus transmission, Acute Flaccid Paralysis (AFP) surveillance and laboratory investigations was initiated in 1995 in Indonesia. The last indigenous wild poliovirus found at 1995 in Indonesia. Indonesia still has the threat of imported wild polio viruses from endemic countries and poliovirus mutation from vaccine that can cause paralytic as well as wild poliovirus. The aim of this article is to describe the laboratory-based AFP surveillance in Indonesia from 2003-2013 so that it had led the Indonesia certified for polio free in 2014. Methods: Data analysis performed on AFP cases data from all provinces in Indonesia period of 2013-2014. Data were collected from polio laboratories network in Jakarta, Bandung, Surabaya and the Sub Directorate of Surveillance, Directorate of Surveillance and Health Quarantine, Directorate General of Disease Prevention and Control. Data were analyzed using Microsoft Excel program. Results: 305 paralysis cases were caused by imported type 1 wild poliovirus infection were found in 2005 and 2
{"title":"Laboratory-based Acute Flaccid Paralysis surveillance pre-polio free certification: Indonesia experience, 2003-2013","authors":"Nike Susanti, H. Herna","doi":"10.22435/hsji.v10i1.1846","DOIUrl":"https://doi.org/10.22435/hsji.v10i1.1846","url":null,"abstract":"Latar belakang: Virus Polio Liar dapat menyebabkan kelumpuhan dan dapat dicegah dengan imunisasi. Untuk memonitor transmisi virus polio liar dilakukan surveilans Acute Flaccid Paralysis (AFP) dan investigasi laboratorium yang telah dimulai sejak tahun 1995 di Indonesia. Virus polio liar Indigenous terakhir ditemukan di Indonesia tahun 1995. Indonesia masih memiliki ancaman importasi virus polio liar dari negara endemis dan mutasi virus polio dari vaksin yang menyebakan kelumpuhan yang sama seperti virus polio liar. Artikel ini bertujuan untuk memberikan gambaran mengenai surveilans AFP berbasis laboratorium di Indonesia pada tahun 2003-2013 sehingga mengantarkan Indonesia sebagai negara bebas polio pada tahun 2014. \u0000Metode: Data yang dianalisis adalah data kasus AFP seluruh Indonesia periode tahun 2003-2013. Data didapat dari laboratorium jejaring laboratorium Polio di Jakarta, Bandung, Surabaya dan Sub Direktorat Surveilans, Direktorat Surveilans dan Karantina Kesehatan, Direktorat Jenderal Pencegahan dan Pengendalian Penyakit. Data di analisis menggunakan program Microsoft Excel. \u0000Hasil: Sebanyak 305 kasus AFP yang disebabkan oleh infeksi virus polio liar tipe 1 impor ditemukan pada tahun 2005 dan 2006. Terdapat 39 kasus AFP yang disebabkan cVDPV tipe 1 ditemukan di Pulau Madura pada tahun 2005. Virus polio liar tipe 1 hanya ditemukan di pulau Sumatera dan Jawa. Penyebaran Virus polio berhasil dihentikan pada tahun 2006 dan sudah tidak ditemukan lagi hingga tahun 2013. \u0000Kesimpulan: Surveilans AFP berbasis laboratorium yang baik berhasil memantau dan mendeteksi sirkulasi virus polio. Peningkatan kinerja surveillance AFP diperlukan untuk membuktikan terhentinya transmisi virus polio sehingga eradikasi polio secara global dapat diraih. \u0000Kata kunci: surveilans, laboratorium polio, Acute Flaccid Paralysis \u0000 \u0000Abstract \u0000Background: Wild Poliovirus can cause flaccid paralysis and can be prevented by immunization. To monitor wild polio virus transmission, Acute Flaccid Paralysis (AFP) surveillance and laboratory investigations was initiated in 1995 in Indonesia. The last indigenous wild poliovirus found at 1995 in Indonesia. Indonesia still has the threat of imported wild polio viruses from endemic countries and poliovirus mutation from vaccine that can cause paralytic as well as wild poliovirus. The aim of this article is to describe the laboratory-based AFP surveillance in Indonesia from 2003-2013 so that it had led the Indonesia certified for polio free in 2014. \u0000Methods: Data analysis performed on AFP cases data from all provinces in Indonesia period of 2013-2014. Data were collected from polio laboratories network in Jakarta, Bandung, Surabaya and the Sub Directorate of Surveillance, Directorate of Surveillance and Health Quarantine, Directorate General of Disease Prevention and Control. Data were analyzed using Microsoft Excel program. \u0000Results: 305 paralysis cases were caused by imported type 1 wild poliovirus infection were found in 2005 and 2","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47660283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-26DOI: 10.22435/hsji.v10i1.1847
P. Wahidiyat, Elida Marpaung, S. Iskandar
Latar belakang: Reaksi transfusi akut (RTA) merupakan sekelompok kejadian yang tidak diinginkan akibat pemberian transfusi darah. Manifestasi dari RTA bervariasi dari yang ringan hingga mengancam nyawa. Saat ini, data mengenai reaksi transfusi di Indonesia masih sangat terbatas. Dalam studi ini, kami bertujuan untuk memberikan gambaran mengenai karakteristik RTA dan faktor-faktor yang mempengaruhinya. Metode: Studi ini merupakan studi retrospektif yang melibatkan 288 subyek dengan RTA. Studi dilakukan di Rumah Sakit Dr. Cipto Mangunkusumo, dimulai sejak Januari hingga Desember 2017. RTA dikelompokkan berdasarkan sistem tubuh yang mengalami manifestasi, serta derajat manifestasinya. Hasil: Sel darah merah merupakan produk darah utama yang ditransfusikan ke subyek, diikuti dengan konsentrat trombosit, plasma segar beku, dan kriopresipitat. Lima gejala utama dari RTA adalah gatal, demam/kenaikan suhu tubuh, menggigil, urtikaria, dan angioedema. Berdasarkan sistem tubuh yang terkena, umumnya RTA bermanifestasi sebagai gejala pada kulit (56.6%). Berdasarkan derajat manifestasinya, RTA umumnya dikategorikan dalam derajat ringan (55.9%). Anak-anak cenderung mengalami manifestasi yang ringan (64.8%) dan utamanya bermanifestasi pada kulit (65.4%). Riwayat transfusi mempengaruhi derajat RTA secara signifikan. RTA derajat sedang dan gejala konstitusional lebih banyak ditemukan pada subyek yang mendapat PRC dibanding produk darah lainnya. Kesimpulan: Umumnya RTA bermanifestasi sebagai gejala dermatologi. Hanya sedikit kasus RTA yang disebabkan oleh reaksi inkompatibilitas. Manifestasi dan derajat RTA juga dipengaruhi oleh umur, riwayat transfusi, dan jenis komponen darah. Kata kunci: Transfusi darah, reaksi transfusi akut, riwayat transfuse, usia Abstract Background: Acute transfusion reactions (ATRs) are a group of adverse events caused by blood transfusions. Manifestations of ATRs vary from mild to life threatening. At present, data about transfusion reactions in Indonesia are still limited. In this study, we aim to determine the characteristics of ATRs and its related factors. Methods: This was a retrospective study of 288 subjects with ATRs. The study was conducted in Cipto Mangunkusumo Hospital, started from January to December 2017. ATRs were categorized based on the body systems affected and degree of manifestations. Results: Packed red cells (PRC) was the predominant blood product (51.4%) which was transfused to subjects, followed by thrombocyte concentrate (TC), fresh frozen plasma (FFP), and cryoprecipitate. Five most common predominant symptoms of ATRs were pruritus/itch, febrile/increased temperature, chills, transient urticaria, and angioedema. Based on the affected body systems, the majority of ATRs manifested as dermatologic symptoms (56.6%). Based on the degree of manifestations, the majority of ATRs were categorized as mild degree (55.9%). Children tended to have milder symptoms (64.8%), which mostly manifested as dermatologic
{"title":"Characteristics of Acute Transfusion Reactions and its related factors in Cipto Mangunkusumo Hospital Jakarta, Indonesia","authors":"P. Wahidiyat, Elida Marpaung, S. Iskandar","doi":"10.22435/hsji.v10i1.1847","DOIUrl":"https://doi.org/10.22435/hsji.v10i1.1847","url":null,"abstract":"Latar belakang: Reaksi transfusi akut (RTA) merupakan sekelompok kejadian yang tidak diinginkan akibat pemberian transfusi darah. Manifestasi dari RTA bervariasi dari yang ringan hingga mengancam nyawa. Saat ini, data mengenai reaksi transfusi di Indonesia masih sangat terbatas. Dalam studi ini, kami bertujuan untuk memberikan gambaran mengenai karakteristik RTA dan faktor-faktor yang mempengaruhinya. \u0000Metode: Studi ini merupakan studi retrospektif yang melibatkan 288 subyek dengan RTA. Studi dilakukan di Rumah Sakit Dr. Cipto Mangunkusumo, dimulai sejak Januari hingga Desember 2017. RTA dikelompokkan berdasarkan sistem tubuh yang mengalami manifestasi, serta derajat manifestasinya. \u0000Hasil: Sel darah merah merupakan produk darah utama yang ditransfusikan ke subyek, diikuti dengan konsentrat trombosit, plasma segar beku, dan kriopresipitat. Lima gejala utama dari RTA adalah gatal, demam/kenaikan suhu tubuh, menggigil, urtikaria, dan angioedema. Berdasarkan sistem tubuh yang terkena, umumnya RTA bermanifestasi sebagai gejala pada kulit (56.6%). Berdasarkan derajat manifestasinya, RTA umumnya dikategorikan dalam derajat ringan (55.9%). Anak-anak cenderung mengalami manifestasi yang ringan (64.8%) dan utamanya bermanifestasi pada kulit (65.4%). Riwayat transfusi mempengaruhi derajat RTA secara signifikan. RTA derajat sedang dan gejala konstitusional lebih banyak ditemukan pada subyek yang mendapat PRC dibanding produk darah lainnya. \u0000Kesimpulan: Umumnya RTA bermanifestasi sebagai gejala dermatologi. Hanya sedikit kasus RTA yang disebabkan oleh reaksi inkompatibilitas. Manifestasi dan derajat RTA juga dipengaruhi oleh umur, riwayat transfusi, dan jenis komponen darah. \u0000Kata kunci: Transfusi darah, reaksi transfusi akut, riwayat transfuse, usia \u0000 \u0000Abstract \u0000 \u0000Background: Acute transfusion reactions (ATRs) are a group of adverse events caused by blood transfusions. Manifestations of ATRs vary from mild to life threatening. At present, data about transfusion reactions in Indonesia are still limited. In this study, we aim to determine the characteristics of ATRs and its related factors. \u0000Methods: This was a retrospective study of 288 subjects with ATRs. The study was conducted in Cipto Mangunkusumo Hospital, started from January to December 2017. ATRs were categorized based on the body systems affected and degree of manifestations. \u0000Results: Packed red cells (PRC) was the predominant blood product (51.4%) which was transfused to subjects, followed by thrombocyte concentrate (TC), fresh frozen plasma (FFP), and cryoprecipitate. Five most common predominant symptoms of ATRs were pruritus/itch, febrile/increased temperature, chills, transient urticaria, and angioedema. Based on the affected body systems, the majority of ATRs manifested as dermatologic symptoms (56.6%). Based on the degree of manifestations, the majority of ATRs were categorized as mild degree (55.9%). Children tended to have milder symptoms (64.8%), which mostly manifested as dermatologic","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42594745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-26DOI: 10.22435/hsji.v10i1.1604
M. Nadjib, P. Sucahya, M. Korib, R. Oktarina, P. Pujiyanto, A. Megraini, H. Hartati, P. Harimurti
Latar belakang: Setelah sekian tahun bergantung pada sumber pendaaan luar negeri, pembiayaan Program HIV AIDS di Indonesia diharapkan menggunakan sumber pendanaan dalam negeri. Skema Jaminan Kesehatan Semesta atau Jaminan Kesehatan Nasional (JKN) yang dimulai tahun 2014 menanggung pengobatan termasuk infeksi oportunistik. Pertanyaan penelitian apakah paket manfaatnya dapat mencakup intervensi kesehatan masyarakat seperti HIV tanpa menghambat penyediaan pelayanan? Implementasi untuk Program HIV yang selama ini disubsidi Pemerintah memerlukan kehati-hatian. Studi ini bertujuan untuk menganalisis skenario terkait biaya dan utilisasi pada pelayanan HIV guna mendukung kebijakan yang potensial untuk mengintegrasikan intervensi HIV ke dalam paket manfaat JKN. Metode: Penelitian ini menganalisis paket manfaat dan mekanisme pembiayaan terkait pelayanan HIV, keanggotaan JKN, target populasi kunci, serta estimasi premi untuk pelayanan HIV hingga tahun 2019. Studi observasional ini menghasilkan data biaya dan utilisasi dari tingkat nasional dan daerah sebagai data dasar. Peneliti membangun model dan menganalisis skenario proyeksi biaya dan utilisasi dari beragam program aktivitas HIV serta konsekuensinya. Hasil: Skenario dikembangkan berdasarkan kelengkapan paket manfaat dan komponen mana yang bisa dijamin dalam JKN.Pelayanan yang terkait HIV saat ini sebagian besar dijamin oleh pemerintah mulai dari Konseling dan Tes HIV Sukarela (KTS) hingga pengobatan Infeksi Oportunistik. Pengobatan dan perawatan kemungkinan dapat dijamin oleh JKN, dengan bantuan pemerintah untuk pencegahan dan pelayanan ART. Kesimpulan: Skenario dengan paket manfaat dasar akan membutuhkan biaya medis yang rasional per pasien per bulan, tergantung pada kelengkapan paket manfaat. Sebuah peta jalan yang jelas perlu disusun untuk memastikan seluruh pelayanan terjangkau dan berkualitas baik. Kata kunci: Jaminan kesehatan semesta, pelayanan HIV, dan Opsi Kebijakan Abstract Background: HIV and AIDS program in Indonesia is planned to be financed by domestic sources after depending on external sources for many years. Indonesia has started its Social Health Insurance scheme so called Jaminan Kesehatan Nasional (JKN) program in 2014, that covers HIV treatment including opportunistic infection. Research question is whether JKN could expand its benefit package to public health interventions without hampering service provision. Converting HIV program that has been subsidizied by the Government needs careful considerations. The study aimed to assess scenarios on cost and utilization to support decision on integration of HIV interventions into the JKN benefit package. Methods: The study assessed the current coverage and funding mechanisms for HIV-related services, JKN membership, key target populations, and estimated premium for HIV services up to 2019. We captured cost and utilization from national and subnational levels as the baseline through an observational study. Researchers develop
{"title":"Policy options to integrate HIV services into Social Health Insurance (JKN) in Indonesia","authors":"M. Nadjib, P. Sucahya, M. Korib, R. Oktarina, P. Pujiyanto, A. Megraini, H. Hartati, P. Harimurti","doi":"10.22435/hsji.v10i1.1604","DOIUrl":"https://doi.org/10.22435/hsji.v10i1.1604","url":null,"abstract":"Latar belakang: Setelah sekian tahun bergantung pada sumber pendaaan luar negeri, pembiayaan Program HIV AIDS di Indonesia diharapkan menggunakan sumber pendanaan dalam negeri. Skema Jaminan Kesehatan Semesta atau Jaminan Kesehatan Nasional (JKN) yang dimulai tahun 2014 menanggung pengobatan termasuk infeksi oportunistik. Pertanyaan penelitian apakah paket manfaatnya dapat mencakup intervensi kesehatan masyarakat seperti HIV tanpa menghambat penyediaan pelayanan? Implementasi untuk Program HIV yang selama ini disubsidi Pemerintah memerlukan kehati-hatian. Studi ini bertujuan untuk menganalisis skenario terkait biaya dan utilisasi pada pelayanan HIV guna mendukung kebijakan yang potensial untuk mengintegrasikan intervensi HIV ke dalam paket manfaat JKN. \u0000Metode: Penelitian ini menganalisis paket manfaat dan mekanisme pembiayaan terkait pelayanan HIV, keanggotaan JKN, target populasi kunci, serta estimasi premi untuk pelayanan HIV hingga tahun 2019. Studi observasional ini menghasilkan data biaya dan utilisasi dari tingkat nasional dan daerah sebagai data dasar. Peneliti membangun model dan menganalisis skenario proyeksi biaya dan utilisasi dari beragam program aktivitas HIV serta konsekuensinya. \u0000Hasil: Skenario dikembangkan berdasarkan kelengkapan paket manfaat dan komponen mana yang bisa dijamin dalam JKN.Pelayanan yang terkait HIV saat ini sebagian besar dijamin oleh pemerintah mulai dari Konseling dan Tes HIV Sukarela (KTS) hingga pengobatan Infeksi Oportunistik. Pengobatan dan perawatan kemungkinan dapat dijamin oleh JKN, dengan bantuan pemerintah untuk pencegahan dan pelayanan ART. \u0000Kesimpulan: Skenario dengan paket manfaat dasar akan membutuhkan biaya medis yang rasional per pasien per bulan, tergantung pada kelengkapan paket manfaat. Sebuah peta jalan yang jelas perlu disusun untuk memastikan seluruh pelayanan terjangkau dan berkualitas baik. \u0000Kata kunci: Jaminan kesehatan semesta, pelayanan HIV, dan Opsi Kebijakan \u0000 \u0000Abstract \u0000 \u0000Background: HIV and AIDS program in Indonesia is planned to be financed by domestic sources after depending on external sources for many years. Indonesia has started its Social Health Insurance scheme so called Jaminan Kesehatan Nasional (JKN) program in 2014, that covers HIV treatment including opportunistic infection. Research question is whether JKN could expand its benefit package to public health interventions without hampering service provision. Converting HIV program that has been subsidizied by the Government needs careful considerations. The study aimed to assess scenarios on cost and utilization to support decision on integration of HIV interventions into the JKN benefit package. \u0000Methods: The study assessed the current coverage and funding mechanisms for HIV-related services, JKN membership, key target populations, and estimated premium for HIV services up to 2019. We captured cost and utilization from national and subnational levels as the baseline through an observational study. Researchers develop","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43078984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-26DOI: 10.22435/hsji.v10i1.1265
I. D. Sari, H. Hendarwan, Rizqiana Halim
Latar Belakang: Faktor geografi Indonesia yang berupa daratan, lautan, pegunungan, dan pulau-pulau yang tersebar menyebabkan distribusi tenaga kesehatan dan akses pelayanan kesehatan yang tidak optimal. Berdasarkan Peraturan menteri kesehatan yang telah ditetapkan, pemerintah berupaya mendayagunakan secara khusus sumber daya manusia kesehatan dalam kurun waktu tertentu dengan jumlah dan jenis tertentu, agar meningkatkan akses dan mutu pelayanan kesehatan pada fasilitas pelayanan kesehatan khususnya di wilayah Daerah Tertinggal, Perbatasan, dan Kepulauan (DTPK) dan Daerah Bermasalah Kesehatan (DBK) melalui Program Nusantara Sehat (NS). Metode: Tahun 2015 telah ditugaskan Tim NS Batch 1 dan 2 pada 120 Puskesmas di DTPK dan DBK selama 2 tahun. Kemudian pada tahun 2017 setelah masa tugas berakhir, diadakan evaluasi program yang bertujuan untuk mengetahui dampak program NS terhadap indeks kesehatan masyarakat dengan menggunakan desain Pre and Post-Test Intervention with Control. Evaluasi dilakukan di 15 provinsi, 27 kabupaten, dan 60 Puskesmas pada bulan Februari - Desember 2017. Hasil: Hasil evaluasi program menunjukkan bahwa pada tahun 2017 terjadi perubahan rata-rata indeks kesehatan masyarakat dibandingkan dengan tahun 2015, baik pada Puskesmas intervensi maupun kontrol (p=0,000). Kemudian hasil uji independen t-test terhadap delta perubahan indeks menunjukkan bahwa peningkatan indeks kesehatan masyarakat pada Puskesmas intervensi lebih besar dibandingkan dengan Puskesmas kontrol (p=0,046). Kesimpulan: penugasan Tim NS pada Puskesmas telah membawa perbaikan indeks kesehatan masyarakat yang lebih baik. Diperlukan pengamatan lebih jauh terkait sustainabilitas Program NS dan analisis biaya manfaat (cost benefit analysis) terhadap Program NS. Kata Kunci: Evaluasi program, Nusantara Sehat, Indeks Kesehatan Masyarakat, Indonesia. Abstract Backgrounds: Indonesia’s geographical factors in the form of land, oceans, mountains, and scattered islands have caused the distribution of health workforce and access to health services are not optimal. Based on the Minister of Health regulation, the government seeks to utilize health human resources specifically for a certain period, with certain number and types, in order to improve access and quality of health service to health service facilities, especially in remote area through the Nusantara Sehat Program (Health Indonesia Program-NS). Methods: In 2015, NS Team Batch 1 and 2 were assigned to 120 primary health care center (Puskesmas) in remote areas for 2 years. Then in 2017 after the term ends, NS program evaluation were conducted in 15 provinces, 27 districts, and 60 Puskesmas from Feb to Dec 2017. Results: This evaluation aims to analyze the impact of NS program on public health index using Pre and Post Test Intervention with Control Design. The results of program evaluation showed that in 2017 there was a change in the average public health index compared to 2015, both in intervention and control
背景:印度尼西亚大陆、海洋、山脉和岛屿分散的地理因素导致卫生保健的分配和医疗服务不理想。根据卫生部长指定的规则,政府试图原本特别卫生人力资源数量和类型的特定时间内访问,以便提高医疗质量和医疗保健设施的特别是在落后地区、边境地区和岛屿地区(DTPK)和(DBK)通过群岛项目健康卫生问题(NS)。方法:2015年在DTPK和DBK分配了120个Puskesmas的NS第1批和第2批团队两年。然后在2017年，在任务结束后，有一个项目评估计划，旨在利用预测和后测试与控制的设计来了解NS计划对公共卫生指数的影响。该评估于2017年2月至12月在15个省、27个地区和60个Puskesmas进行。结果:项目评估结果显示，与2015年相比，公共卫生指数(Puskesmas干预和控制(p= 10000)的平均变化。然后，对delta变化的独立t测试结果表明，公共卫生干预措施的增加比控制措施的增加要大(p= 046)。结论:NS团队在Puskesmas的任务带来了更好的公共卫生指数。需要对NS计划的支持和成本分析对NS计划进行进一步观察。关键词:项目评估，健康群岛，公共卫生索引，印度尼西亚。土壤:印度尼西亚的地理因素在其土壤、海洋、山脉和分散的岛屿上造成了健康劳动力和获得健康服务的分布不是最理想的。regulation),卫生部部长》改编自《政府晕到utilize健康人力资源部把for a确定期确定的数字和types,在订单to improve access and the supreme quality of Health service to Health service) facilities穿过群岛区域,尤其是在远程健康(Health)印度尼西亚Program-NS项目)。方法:2015年，NS第1批和第2批被分配到偏远地区120初级医疗中心两年。然后在2017年，在term ends之后，NS评估计划被分配到15个省，27个地区，以及从2月到2017年12月60个地方。建议:使用预测和后试验控制设计测试分析公共卫生项目影响影响的评估aims。2017年，公共卫生指数(average public health index)的结果显示，2015年公共卫生指数(p)出现了变化。《经济增长与公共卫生指数》变化后的独立性t-测试结果显示，公共卫生指数的进步远远大于控制。结论:公共卫生部门的任务带来了改善。进一步的观察需要考虑资源和成本分析方案。Keywords:印度尼西亚的Nusantara健康、公共卫生索引计划。
{"title":"The evaluation of Nusantara Sehat program using Nusantara Sehat Public Health Index","authors":"I. D. Sari, H. Hendarwan, Rizqiana Halim","doi":"10.22435/hsji.v10i1.1265","DOIUrl":"https://doi.org/10.22435/hsji.v10i1.1265","url":null,"abstract":"Latar Belakang: Faktor geografi Indonesia yang berupa daratan, lautan, pegunungan, dan pulau-pulau yang tersebar menyebabkan distribusi tenaga kesehatan dan akses pelayanan kesehatan yang tidak optimal. Berdasarkan Peraturan menteri kesehatan yang telah ditetapkan, pemerintah berupaya mendayagunakan secara khusus sumber daya manusia kesehatan dalam kurun waktu tertentu dengan jumlah dan jenis tertentu, agar meningkatkan akses dan mutu pelayanan kesehatan pada fasilitas pelayanan kesehatan khususnya di wilayah Daerah Tertinggal, Perbatasan, dan Kepulauan (DTPK) dan Daerah Bermasalah Kesehatan (DBK) melalui Program Nusantara Sehat (NS). \u0000Metode: Tahun 2015 telah ditugaskan Tim NS Batch 1 dan 2 pada 120 Puskesmas di DTPK dan DBK selama 2 tahun. Kemudian pada tahun 2017 setelah masa tugas berakhir, diadakan evaluasi program yang bertujuan untuk mengetahui dampak program NS terhadap indeks kesehatan masyarakat dengan menggunakan desain Pre and Post-Test Intervention with Control. Evaluasi dilakukan di 15 provinsi, 27 kabupaten, dan 60 Puskesmas pada bulan Februari - Desember 2017. \u0000Hasil: Hasil evaluasi program menunjukkan bahwa pada tahun 2017 terjadi perubahan rata-rata indeks kesehatan masyarakat dibandingkan dengan tahun 2015, baik pada Puskesmas intervensi maupun kontrol (p=0,000). Kemudian hasil uji independen t-test terhadap delta perubahan indeks menunjukkan bahwa peningkatan indeks kesehatan masyarakat pada Puskesmas intervensi lebih besar dibandingkan dengan Puskesmas kontrol (p=0,046). \u0000Kesimpulan: penugasan Tim NS pada Puskesmas telah membawa perbaikan indeks kesehatan masyarakat yang lebih baik. Diperlukan pengamatan lebih jauh terkait sustainabilitas Program NS dan analisis biaya manfaat (cost benefit analysis) terhadap Program NS. \u0000Kata Kunci: Evaluasi program, Nusantara Sehat, Indeks Kesehatan Masyarakat, Indonesia. \u0000 \u0000Abstract \u0000Backgrounds: Indonesia’s geographical factors in the form of land, oceans, mountains, and scattered islands have caused the distribution of health workforce and access to health services are not optimal. Based on the Minister of Health regulation, the government seeks to utilize health human resources specifically for a certain period, with certain number and types, in order to improve access and quality of health service to health service facilities, especially in remote area through the Nusantara Sehat Program (Health Indonesia Program-NS). \u0000Methods: In 2015, NS Team Batch 1 and 2 were assigned to 120 primary health care center (Puskesmas) in remote areas for 2 years. Then in 2017 after the term ends, NS program evaluation were conducted in 15 provinces, 27 districts, and 60 Puskesmas from Feb to Dec 2017. \u0000Results: This evaluation aims to analyze the impact of NS program on public health index using Pre and Post Test Intervention with Control Design. The results of program evaluation showed that in 2017 there was a change in the average public health index compared to 2015, both in intervention and control","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48433482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-26DOI: 10.22435/hsji.v10i1.1081
P. S. Hidayangsih
Latar belakang: Kanker serviks merupakan penyakit kanker dengan prevalensi tertinggi di Indonesia. Penelitian ini bertujuan untuk mengidentifikasi hubungan antara wilayah tempat tinggal, perilaku kebersihan diri, dan lesi prakanker serviks pada wanita pernah kawin umur 25-64 tahun di Indonesia. Metode: Studi ini menggunakan data Riset Penyakit Tidak Menular tahun 2016 di daerah perkotaan di 34 provinsi Indonesia. Populasi dan sampel adalah wanita pernah kawin berusia 25-64 tahun yang diwawancara dan dilakukan pengambilan apus serviks menggunakan metode Inspeksi Visual Asetat (IVA) untuk mengetahui indikasi prevalensi lesi prakanker serviks. Analisis hubungan menggunakan regresi logistik dengan metode enter, dengan total sampel yang dianalisis 37.456 responden. Hasil: Hasil analisis menemukan proporsi 7% wanita dengan hasil tes IVA positif. Wanita yang tinggal di sekitar lokasi industri berisiko 1,2 kali (Adjusted OR= 1,2; 95% CI= 1,1-1,4) positif terhadap hasil periksa IVA daripada mereka yang tidak tinggal di wilayah tersebut. Sedangkan perilaku hygiene perorangan seperti membersihkan alat kelamin setelah selesai berhubungan seksual tidak bermakna secara signifikan terhadap hasil IVA positif. Kesimpulan: Ada hubungan antara tinggal di lingkungan industri dengan hasil IVA positif pada wanita usia 25 64 tahun menunjukkan pentingnya penapisan dini secara teratur pada wanita terutama yang tinggal daerah industri. Kata kunci: Lesi prakanker, serviks, IVA, lingkungan, industri Abstract Background: Cervical cancer is a cancer with the highest prevalence in Indonesia. This study aims to identify the relationship between residential area, personal hygiene behavior, and precancerous cervical lesions in ever married women aged 25-64 years in Indonesia. Methods: This study uses data on the 2016 Non-Communicable Disease Research in urban areas in 34 Indonesian provinces. The population and sample were ever-married women aged 25-64 years who were interviewed and also performed cervical smear extraction using the Visual Inspection with Acetic Acid (VIA) method to determine indications of the prevalence of cervical precancerous lesions. Relationship analysis using logistic regression with enter method, with a total sample analyzed by 37,456 respondents. Results: The results of the analysis found a proportion of 7% of women with positive VIA test results. Women living in the vicinity of industrial sites were 1.2 times at risk (Adjusted OR = 1.2; 95% CI = 1.1-1.4) positive for VIA results than those who did not live in the area. While individual hygiene behaviors such as cleaning genitals after completing sexual intercourse did not significantly affect the positive VIA results. Conclusion: There is a relationship between living in an industrial environment with positive VIA results in women aged 25-64 years showing the importance of regular early screening among women, especially those who live in industrial areas. Keywords: Precancerous lesions, c
{"title":"Residential area, hygiene behaviour, and pre-cervical lesions of women aged 25-64 years in Indonesia","authors":"P. S. Hidayangsih","doi":"10.22435/hsji.v10i1.1081","DOIUrl":"https://doi.org/10.22435/hsji.v10i1.1081","url":null,"abstract":"Latar belakang: Kanker serviks merupakan penyakit kanker dengan prevalensi tertinggi di Indonesia. Penelitian ini bertujuan untuk mengidentifikasi hubungan antara wilayah tempat tinggal, perilaku kebersihan diri, dan lesi prakanker serviks pada wanita pernah kawin umur 25-64 tahun di Indonesia. \u0000Metode: Studi ini menggunakan data Riset Penyakit Tidak Menular tahun 2016 di daerah perkotaan di 34 provinsi Indonesia. Populasi dan sampel adalah wanita pernah kawin berusia 25-64 tahun yang diwawancara dan dilakukan pengambilan apus serviks menggunakan metode Inspeksi Visual Asetat (IVA) untuk mengetahui indikasi prevalensi lesi prakanker serviks. Analisis hubungan menggunakan regresi logistik dengan metode enter, dengan total sampel yang dianalisis 37.456 responden. \u0000Hasil: Hasil analisis menemukan proporsi 7% wanita dengan hasil tes IVA positif. Wanita yang tinggal di sekitar lokasi industri berisiko 1,2 kali (Adjusted OR= 1,2; 95% CI= 1,1-1,4) positif terhadap hasil periksa IVA daripada mereka yang tidak tinggal di wilayah tersebut. Sedangkan perilaku hygiene perorangan seperti membersihkan alat kelamin setelah selesai berhubungan seksual tidak bermakna secara signifikan terhadap hasil IVA positif. \u0000Kesimpulan: Ada hubungan antara tinggal di lingkungan industri dengan hasil IVA positif pada wanita usia 25 64 tahun menunjukkan pentingnya penapisan dini secara teratur pada wanita terutama yang tinggal daerah industri. \u0000Kata kunci: Lesi prakanker, serviks, IVA, lingkungan, industri \u0000 \u0000Abstract \u0000Background: Cervical cancer is a cancer with the highest prevalence in Indonesia. This study aims to identify the relationship between residential area, personal hygiene behavior, and precancerous cervical lesions in ever married women aged 25-64 years in Indonesia. \u0000Methods: This study uses data on the 2016 Non-Communicable Disease Research in urban areas in 34 Indonesian provinces. The population and sample were ever-married women aged 25-64 years who were interviewed and also performed cervical smear extraction using the Visual Inspection with Acetic Acid (VIA) method to determine indications of the prevalence of cervical precancerous lesions. Relationship analysis using logistic regression with enter method, with a total sample analyzed by 37,456 respondents. \u0000Results: The results of the analysis found a proportion of 7% of women with positive VIA test results. Women living in the vicinity of industrial sites were 1.2 times at risk (Adjusted OR = 1.2; 95% CI = 1.1-1.4) positive for VIA results than those who did not live in the area. While individual hygiene behaviors such as cleaning genitals after completing sexual intercourse did not significantly affect the positive VIA results. \u0000Conclusion: There is a relationship between living in an industrial environment with positive VIA results in women aged 25-64 years showing the importance of regular early screening among women, especially those who live in industrial areas. \u0000Keywords: Precancerous lesions, c","PeriodicalId":30666,"journal":{"name":"Health Science Journal of Indonesia","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49595712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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