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Technical Digest. MEMS 2001. 14th IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.01CH37090)最新文献

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Inline electrochemical detection for capillary electrophoresis 毛细管电泳的在线电化学检测
Ponnambalam Ravi Selvaganapathy, Mark A. Burns, D. T. Burke, C. H. Mastrangelo
This paper presents for the first time fabrication and initial measurements of an electrophoresis stage integrated with a novel inline electrochemical detection system. This detector system can be easily incorporated into plastic substrates and has less complex fabrication procedure compared to fluorescent detection systems. Potentiostatic and Open potential modes of detection are demonstrated. Techniques used to eliminate gas evolution at the detection electrodes and to reduce noise are discussed. Noise levels of 0.7 pA on a signal of 5 nA and drift in signal of 1.18 pA/s were measured for the potentiostatic mode of detection for the field and buffer concentration mentioned. Open potential mode had noise levels of 9.1 mV on a signal of 800 mV and a drift in signal of 0.22 mV/s. The potentiostatic mode was determined to be more stable based on the S/N ratios. Separation and detection of few biologically important compounds along with few electrochemical tags are demonstrated. Detection limits of 14.5 amol were measured for the potentiostatic mode of detection.
本文首次介绍了一种集成了新型在线电化学检测系统的电泳平台的制造和初步测量。与荧光检测系统相比,该检测系统可以很容易地集成到塑料基板中,并且具有较少复杂的制造过程。演示了恒电位和开电位检测模式。讨论了用于消除检测电极处气体演化和降低噪声的技术。在5 nA信号下测量0.7 pA的噪声级,在1.18 pA/s信号下测量漂移,用于恒电位模式检测上述电场和缓冲液浓度。开电位模式对800 mV信号的噪声级为9.1 mV,对0.22 mV/s信号的漂移为0.22 mV/s。基于信噪比,确定了恒电位模式更稳定。分离和检测一些重要的生物化合物和一些电化学标签被证明。采用恒电位法测定了14.5 amol的检出限。
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引用次数: 13
Convection-based micromachined inclinometer using SOI technology 采用SOI技术的对流微机械倾角仪
S. Billat, H. Glosch, M. Kunze, F. Hedrich, J. Frech, J. Auber, W. Lang, H. Sandmaier, W. Wimmer
This paper presents a novel inclinometer operating with the free-convection heat transfer principle which has been developed at the HSG-IMIT for the VOGT electronic company. The use of SOI-technology permits a short technological process for the sensor fabrication and a very good mechanical stability like a high reproducibility. Using free convection properties the sensor presents a high resolution (0.007/spl deg/), a great sensitivity and baseline stability.
本文介绍了为VOGT电子公司在HSG-IMIT研制的一种利用自由对流传热原理工作的新型测斜仪。soi技术的使用使传感器制造的技术过程短,并且具有非常好的机械稳定性,如高再现性。利用自由对流特性,传感器具有高分辨率(0.007/spl度/),高灵敏度和基线稳定性。
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引用次数: 33
A zepto mole DNA micro sensor zepto mole DNA微型传感器
Tza-Huei Wang, S. Masset, Chih-Ming Ho
Using molecular beacons (MB) as highly sensitive and selective nucleic acid probes, we eliminate two of the major but cumbersome steps, probe immobilization and washing, of gene-based biosensors. By integrating sidewall mirrors with microchannels, we can increase the signal-to-noise ratio of the optical detection. The detection specificity is achieved using a MB based DNA hybridization technique. Molecular beacons become fluorescent only upon hybridization with target DNA/RNA molecules as the quencher is separated from the fluorophore. We can hence eliminate washing and immobilization steps and establish the inchannel detection technique. This technique reduces the detection volume to 36 pL. Microchannels coated with metal films with high reflectance are used to increase the signal level in the Laser Induced Fluorescence (LIF) system. By using the side-mirror channel with inchannel sensing technique, the detection limit is 0.07 zmol which is at least 3 orders of magnitude lower than many other DNA detection schemes.
使用分子信标(MB)作为高灵敏度和选择性的核酸探针,我们消除了两个主要但繁琐的步骤,探针固定化和清洗,基于基因的生物传感器。通过将侧壁反射镜与微通道集成,可以提高光学检测的信噪比。使用基于MB的DNA杂交技术实现检测特异性。当猝灭剂与荧光团分离时,分子信标只有在与目标DNA/RNA分子杂交时才会荧光。因此,我们可以消除清洗和固定步骤,建立通道内检测技术。该技术将检测体积降低到36pl。在激光诱导荧光(LIF)系统中,使用涂有高反射率金属薄膜的微通道来提高信号电平。采用侧镜通道和通道内传感技术,检测限为0.07 zmol,比许多其他DNA检测方案低至少3个数量级。
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引用次数: 5
A micromachined resonant magnetic field sensor 一种微机械谐振磁场传感器
T. Leichlé, M. von Arx, M. Allen
A micromachined magnetic field sensor has been designed, fabricated and tested. Its principle of operation is based on the change of resonant frequency of a magnetically sensitive micromechanical resonator as a function of applied external magnetic field. Magnetic sensitivity is achieved by incorporating magnetically soft (permeable) or hard (permanent magnet) materials into the resonator structure. The fabrication of these devices is based on electroplating through sacrificial molds and is completely CMOS-compatible. The functionality of the device has been demonstrated as both an intensity sensor and an angular sensor (i.e., compass). The intensity sensor demonstrated a sensitivity of 20 Oersted in magnetic field intensity, while the angular sensor demonstrated a resolution of approximately 20 degrees. Performance improvements are expected upon integration of these devices with appropriate circuitry.
设计、制作并测试了一种微机械磁场传感器。其工作原理是基于磁敏感微机械谐振器谐振频率随外加磁场的变化而变化。磁灵敏度是通过将磁性软(可渗透)或磁性硬(永磁体)材料纳入谐振器结构来实现的。这些器件的制造是基于牺牲模具的电镀,完全兼容cmos。该设备的功能已被证明为强度传感器和角度传感器(即指南针)。强度传感器在磁场强度下的灵敏度为20奥斯特,而角度传感器的分辨率约为20度。将这些设备与适当的电路集成后,性能有望得到改善。
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引用次数: 15
Low-cost technology for high-density microvalve arrays using polydimethylsiloxane (PDMS) 低成本聚二甲基硅氧烷(PDMS)高密度微阀阵列技术
K. Hosokawa, R. Maeda
In this paper, a rapid and low-cost fabrication technology for high-density microvalve arrays is presented. For proof of the concept, a pneumatically-actuated three-way microvalve system composed of three independent one-way valve units was fabricated and tested. Each valve unit has a membrane, which is actuated by external negative air pressure. Intervals between the valve units are smaller than 780 /spl mu/m. These small intervals have been realized by providing the system with a layer of microchannels to conduct the air pressure to the valve units. All the parts were made of inexpensive silicone elastomer - polydimethylsiloxane (PDMS) - and rapidly fabricated with molding and spin-coating. A newly developed technique for wafer level transfer of a PDMS membrane has been proven to be effective. Flow characteristics of the microvalve system for water are presented. The microvalve works in an on-off manner with hysteresis. No leakage has been observed in the closed state. In the open state, measured flow resistances (pressure drops) are within the range of 1.65-2.29 kPa/(/spl mu/L/min).
本文提出了一种快速、低成本的高密度微阀阵列制造技术。为了验证这一概念,制作并测试了由三个独立单向阀单元组成的气动三通微阀系统。每个阀门单元都有一个膜,由外部负压驱动。阀单元间隔小于780 /spl mu/m。这些小间隔是通过为系统提供一层微通道来将空气压力传导到阀门单元来实现的。所有部件都由廉价的有机硅弹性体——聚二甲基硅氧烷(PDMS)制成,并通过成型和旋转涂层快速制造。一种新开发的硅片级转移技术已被证明是有效的。介绍了水用微阀系统的流量特性。微阀工作在一个开关方式与滞后。在关闭状态下未观察到泄漏。在开启状态下,测量到的流动阻力(压降)范围为1.65 ~ 2.29 kPa/(/spl mu/L/min)。
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引用次数: 11
Characteristics of silicon nano wire as piezoresistor for nano electro mechanical systems 纳米硅纳米线用作纳米机电系统压敏电阻的特性
T. Toriyama, Y. Tanimoto, Susumu Sugiyama
In order to confirm ability of silicon nano wire piezoresistors as sensing element of mechanical sensors, current-voltage (I-V) characteristics and the piezoresistive effect were investigated. Electron beam (EB) direct writing and RIE were used for fabrication. Fabricated polycrystalline Si (poly-Si) nano wire piezoresistors have triangular or trapezoid cross sections. The minimum width is 53 nm and thickness is 32 nm. A remarkable phenomenon was observed. The longitudinal piezoresistive coefficient /spl pi//sub l/ of the nano wire piezoresistor increased with a decrease in the cross section area, while the transverse piezoresistive coefficient /spl pi//sub t/ was approximately zero and invariant despite variation of the cross section area. The maximum value of /spl pi//sub l/ was 22/spl times/10/sup -5/ (1/MPa) at impurity concentration N=5/spl times/10/sup 19/ (cm/sup -3/).
为了验证硅纳米线压敏电阻作为机械传感器传感元件的能力,研究了硅纳米线压敏电阻的电流-电压特性和压阻效应。采用电子束直写法和RIE法制备。制备的多晶硅(多晶硅)纳米线压敏电阻具有三角形或梯形截面。最小宽度为53纳米,厚度为32纳米。人们观察到一个了不起的现象。纵向压阻系数/spl pi//sub - l/随横截面面积的减小而增大,而横向压阻系数/spl pi//sub - t/随横截面面积的变化而近似为零且不变。杂质浓度N=5/spl倍/10/sup - 19/ (cm/sup -3/)时,/spl pi// subl /的最大值为22/spl倍/10/sup -5/ (1/MPa)。
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引用次数: 15
Improved micro-flow regulator for drug delivery systems 改进的药物输送系统微流量调节器
P. Cousseau, R. Hirschi, B. Frehner, S. Gamper, D. Maillefer
The paper reports on the design, manufacturing, and experimental testing of a micromachined pressure compensating flow regulator. This device was designed to provide a constant liquid flow rate of 1 ml/hr within a pressure difference of 100 to 600 mbar. At pressures higher than 600 mbar the device is designed to block the flow, preventing an over-delivery of medicine. Structural and fluidic simulations were used to design the geometry of the device before manufacturing. After devices have been characterized experimental results demonstrate the credibility of the design, the accuracy of the flow rate and the long-term stability of the device. One application of this device is the replacement of the flow restrictor in an elastomeric infusion system, which will increase the accuracy and safety of the drug delivery system. This pressure compensating flow regulator is passive, hence it needs no external energy source. The device is relatively inexpensive to manufacture and is therefore, potentially a disposable unit in a microfluidic system. Finally, it is small and lightweight, ideal for portable applications.
本文介绍了一种微型机械压力补偿式流量调节器的设计、制造和实验测试。该装置设计用于在100至600毫巴的压力差范围内提供1毫升/小时的恒定液体流速。当压力高于600毫巴时,该装置被设计成阻塞流动,防止药物过量输送。在制造之前,使用结构和流体模拟来设计装置的几何形状。在对装置进行了表征后,实验结果证明了设计的可信性、流量的准确性和装置的长期稳定性。该装置的一个应用是替代弹性输液系统中的流量限制器,这将提高药物输送系统的准确性和安全性。这种压力补偿式流量调节器是被动的,因此不需要外部能源。该装置制造成本相对较低,因此有可能成为微流体系统中的一次性装置。最后,它体积小、重量轻,是便携式应用的理想选择。
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引用次数: 29
Dual-axes capacitive inclinometer/low-g accelerometer for automotive applications 用于汽车应用的双轴电容式倾角计/低加速度计
D. Lăpădatu, S. Habibi, B. Reppen, G. Salomonsen, T. Kvisterøy
This paper reports a dual-axes capacitive inclinometer/low-g accelerometer based on a novel feedback operation concept. The device consists of a sensor die and an ASIC, housed in a dual-in-line transfer moulded package for surface mounting. The sensor is fabricated by bulk micromachining of silicon and triple stack anodic bonding and is primarily an accelerometer sensitive to the Earth's gravitational field. Through the dedicated ASIC, the device can be programmed to operate either as a low-g accelerometer or as an inclinometer. The device is designed to have a programmable range up to /spl plusmn/2 g for the accelerometer and up to /spl plusmn/40/spl deg/ for the inclinometer, and a resolution of 0.61 mg and 0.1/spl deg/, respectively.
本文报道了一种基于新型反馈工作原理的双轴电容式倾角计/低加速度计。该器件由传感器芯片和ASIC组成,封装在双列传输模塑封装中,用于表面安装。该传感器采用硅块微加工和三层阳极键合技术制成,主要是对地球引力场敏感的加速度计。通过专用ASIC,可以对该设备进行编程,使其既可以作为低加速度计,也可以作为倾角计。该器件的可编程范围为加速度计可达/spl plusmn/ 2g,倾角计可达/spl plusmn/40/spl°/,分辨率分别为0.61 mg和0.1/spl°/。
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引用次数: 37
Bulk micromachined angular rate sensor based on the 'butterfly'-gyro structure 基于“蝶形”陀螺结构的体微机械角速度传感器
N. Hedenstierna, S. Habibi, S. Nilsen, T. Kvisterøy, G. U. Jensen
The principle of the butterfly-gyro was first demonstrated with a large anisotropically etched structure in bulk silicon. Now the same principle has been used to develop a much smaller structure (9.6 mm/sup 2/). The new sensor chip is ICP-etched in bulk silicon and anodically bonded to form a triple stack (glass/Si/glass) structure. Together with an ASIC the sensor typically shows a noise level of 0.3 /sup o///sub s/ over 50 Hz bandwidth and a zero-rate offset (ZRO) less than 50 /sup o///sub s/.
蝴蝶陀螺的工作原理首先通过在大块硅上的大的各向异性蚀刻结构得到了证明。现在,同样的原理已被用于开发更小的结构(9.6毫米/sup 2/)。新的传感器芯片在大块硅中进行icp蚀刻,并用阳极键合形成三重堆栈(玻璃/硅/玻璃)结构。与ASIC一起,传感器通常在50 Hz带宽上显示0.3 /sup o///sub s/的噪声水平和小于50 /sup o///sub s/的零速率偏移(ZRO)。
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引用次数: 42
Fabrication of 3-dimensional microstructures using moving mask deep X-ray lithography (M/sup 2/DXL) 移动掩模深x射线光刻(M/sup 2/DXL)制备三维微结构
O. Tabata, N. Matsuzuka, T. Yamaji, Hui You, J. Minakuchi, K. Yamamoto
Two methods, "Forward Approach" and "Inverse Approach", to fabricate complicated 3-dimensional microstructures by deep X-ray lithography have been developed. In the "Forward Approach", exposure energy distribution on a PMMA substrate was calculated using X-ray mask pattern and mask moving trajectories. Two different micro-nozzle patterns were fabricated to demonstrate the feasibility of this approach. From the comparison between prediction and experiment, a new phenomenon related to the long lifetime radicals was observed. As the "Inverse Approach", a method to determine the optimum mask moving trajectory using Fourier transformation was developed.
利用深x射线光刻技术制备复杂三维微结构的方法有“正向法”和“逆法”两种。在“正向法”中,利用x射线掩模模式和掩模移动轨迹计算PMMA衬底上的暴露能量分布。制备了两种不同形状的微喷嘴,验证了该方法的可行性。通过预测与实验的比较,发现了一个与长寿命自由基有关的新现象。作为“逆方法”,提出了一种利用傅里叶变换确定最佳掩模运动轨迹的方法。
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引用次数: 20
期刊
Technical Digest. MEMS 2001. 14th IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.01CH37090)
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