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An integrative review of the effects of high-intensity interval training on the autonomic nervous system 高强度间歇训练对自律神经系统影响的综合评述。
IF 2.3 Q2 SPORT SCIENCES Pub Date : 2024-08-20 DOI: 10.1016/j.smhs.2024.08.002
Massimo Coretti , Nathalia Nahas Donatello , Gianluca Bianco , Francisco J. Cidral-Filho
High-Intensity Interval Training (HIIT) has gained prominence as a time-efficient and effective exercise modality to improve cardiovascular (CV) fitness, metabolic health, and physical performance. Therefore, our aim was to synthesize current clinical research on the effects of HIIT on the Autonomic Nervous System. We conducted the search for studies in the Directory of Open Access Journals, Embase, Virtual Health Library, Pubmed, and Scielo databases, in January of 2024. We included a total of 20 studies in our review. This literature review highlights the potential of HIIT to modulate the Autonomic Nervous System, enhancing CV function and overall health. Despite the promising findings, the interpretation of the results is tempered by the variability in study designs, populations, and methodologies. Future research should address these limitations, aiming for a more nuanced understanding of the relationship between HIIT and Autonomic Nervous System function. The review indicates that standardized protocols need to consider individual characteristics and baseline autonomic states for clinical application. As the body of evidence grows, HIIT may emerge as a cornerstone of exercise prescriptions aimed at optimizing autonomic function and promoting CV health.
高强度间歇训练(HIIT)作为一种时间效率高且有效的运动方式,可以改善心血管(CV)健康、代谢健康和身体表现。因此,我们的目的是综合目前HIIT对自主神经系统影响的临床研究。我们于2024年1月在开放获取期刊目录、Embase、虚拟健康图书馆、Pubmed和Scielo数据库中进行了研究搜索。我们的综述共纳入了20项研究。这篇文献综述强调了HIIT调节自主神经系统、增强心血管功能和整体健康的潜力。尽管这些发现很有希望,但对结果的解释受到研究设计、人群和方法的可变性的影响。未来的研究应该解决这些局限性,旨在更细致地了解HIIT和自主神经系统功能之间的关系。综述表明,标准化方案需要考虑临床应用的个体特征和基线自主神经状态。随着证据的不断增加,HIIT可能会成为旨在优化自主神经功能和促进心血管健康的运动处方的基石。
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引用次数: 0
Observed relationships between nap practices, executive function, and developmental outcomes in Tunisian childcare centers 观察突尼斯托儿中心的午睡实践、执行功能和发展结果之间的关系
IF 2.3 Q2 SPORT SCIENCES Pub Date : 2024-08-08 DOI: 10.1016/j.smhs.2024.08.001
Mohamed-Amine Ltifi , Kar Hau Chong , Ghaith Ben-Bouzaiene , Anthony D. Okely , Mohamed-Souhaiel Chelly
The objective of this design was to conduct an observational study comparing anthropometric characteristics, cognitive functions, as well as gross and fine motor skills. The study included 118 preschool-aged children (47 boys, 71 girls) enrolled in childcare centers. They were categorized into two groups based on their nap habits. The nap group comprised 59 children (23 boys, 36 girls), age (mean ​± ​standard deviation) ([3.96 ​± ​0.54] years) who took naps after lunch, while the no-nap group included 59 children (24 boys, 35 girls) age (mean ​± ​standard deviation) ([4.18 ​± ​0.61] years) who remained awake during this period. The results showed that the napping group had significantly higher scores for body mass index (BMI) (p ​< ​0.000 1), height-for-age z score (HAZ) (p ​= ​0.003), and higher BAZ (BMI-for-age z score) scores (p ​< ​0.000 1), compared to the No-nap group. In terms of cognitive function, the study revealed that the napping group had better working memory performance compared to the No-nap group (p ​= ​0.002), but no significant impact on inhibition was observed. The results also showed that taking a nap may improve functional mobility (p ​= ​0.003) and upper body strength (p ​= ​0.026) especially in boys. Future research could investigate the long-term effects of inadequate nap time on children's health and development and also develop and evaluate interventions to improve nap time habits in preschool children.
本设计的目的是进行一项观察性研究,比较人体测量特征、认知功能以及粗大和精细运动技能。该研究包括118名学龄前儿童(47名男孩,71名女孩)在托儿中心登记。根据他们的午睡习惯,他们被分为两组。午睡组包括59名儿童(男孩23名,女孩36名),年龄(平均±标准差)([3.96±0.54]岁)在午餐后小睡,而不午睡组包括59名儿童(男孩24名,女孩35名)年龄(平均±标准差)([4.18±0.61]岁)在此期间保持清醒。结果显示,午睡组的身体质量指数(BMI)得分显著高于对照组(p <;0.000 1),身高-年龄z评分(HAZ) (p = 0.003), BAZ (bmi -年龄z评分)得分较高(p <;0.000 1),与不午睡组相比。在认知功能方面,研究发现午睡组的工作记忆表现优于不午睡组(p = 0.002),但在抑制方面没有明显影响。结果还表明,午睡可以改善功能活动能力(p = 0.003)和上肢力量(p = 0.026),特别是在男孩中。未来的研究可以探讨午睡时间不足对儿童健康和发育的长期影响,并制定和评估改善学龄前儿童午睡习惯的干预措施。
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引用次数: 0
Affective valence predictors from real-world based short sprint interval training 从基于真实世界的短跑间歇训练中预测情感价位
IF 2.3 Q2 SPORT SCIENCES Pub Date : 2024-07-25 DOI: 10.1016/j.smhs.2024.07.003
Stefano Benítez-Flores , Flávio A. de S. Castro , Eduardo Caldas Costa , Daniel Boullosa , Todd A. Astorino
Affective valence is typically positive at exercise intensities below the lactate threshold, yet more aversive responses occur at supra-threshold intensities. Nevertheless, the physiological and psychological predictors of affective valence during supramaximal intensities including short sprint interval training (sSIT) have not yet been elucidated. Seventeen (7 women/10 men) moderately active young adults (age ​= ​[28.2 ​± ​5.6] years; V˙O2max [maximum oxygen consumption] ​= ​[52.9 ​± ​8.1] mL·kg1·min1; BMI [body mass index] ​= ​[24 ​± ​2] kg·m2) completed four low-volume running sSIT sessions (10 ​× ​4 ​s efforts with 30 ​s of passive recovery). We recorded participants’ heart rate (HR), root mean square of successive differences of normal RR intervals (RMSSD), heart rate recovery (HRR), ratings of perceived exertion (RPE), feeling scale (FS), intention and self-efficacy during, and after each session. Overall, no significant correlation (p ​> ​0.05) was found between FS and baseline clinical outcomes. No significant correlation (p ​> ​0.05) was detected between FS and any training parameter. No significant correlations were noted between FS and exercise task self-efficacy and intentions (p ​> ​0.05). The regression model was significant (F3,61 ​= ​5.57; p ​= ​0.002) and only three variables significantly entered the generated model: ΔHRRend-120s end (p ​= ​0.002; VIF ​= ​2.58; 40.8%), time ≥ 90% HRpeak (p ​= ​0.001; VIF ​= ​1.26; 31.6%), and RMSSDend (p ​= ​0.025; VIF ​= ​2.23; 27.6%). These findings suggest that HR-based measures, particularly those related to in-task stress (time ≥ 90% HRpeak) and acute recovery (ΔHRRend-120s end, and RMSSDend), may predict affective valence during real-world sSIT.
在低于乳酸阈值的运动强度下,情感效价通常是积极的,而在超过阈值的强度下,会出现更多的厌恶反应。然而,在包括短冲刺间歇训练(sSIT)在内的超极大强度期间,情感效价的生理和心理预测因素尚未得到阐明。17例(7名女性/10名男性)中度运动青年(年龄=[28.2±5.6]岁;V˙O2max(最大耗氧量)=(52.9±8.1)毫升·公斤−1·敏−1;BMI[体重指数]=[24±2]kg·m−2)完成4次小容量sSIT运动(10 × 4 s努力,30 s被动恢复)。我们记录了参与者的心率(HR)、正常RR间隔(RMSSD)连续差异的均方根、心率恢复(HRR)、感知运动评分(RPE)、感觉量表(FS)、意图和自我效能感在每次训练期间和之后。总体而言,无显著相关性(p >;FS与基线临床结果之间存在0.05)。无显著相关性(p >;FS与任何训练参数之间均存在0.05)。FS与运动任务自我效能感和意图之间无显著相关(p >;0.05)。回归模型显著(F3,61 = 5.57;p = 0.002),只有三个变量显著进入生成的模型:ΔHRRend-120s end (p = 0.002;vif = 2.58;40.8%),时间≥90% HRpeak (p = 0.001;vif = 1.26;31.6%), RMSSDend (p = 0.025;vif = 2.23;27.6%)。这些发现表明,基于hr的测量,特别是与任务内压力(时间≥90% HRpeak)和急性恢复(ΔHRRend-120s end和rmssend)相关的测量,可以预测真实sSIT期间的情感效价。
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引用次数: 0
Sport-related concussion in Brazilian professional soccer: A four-year prospective epidemiological analysis 巴西职业足球中与运动相关的脑震荡:为期四年的前瞻性流行病学分析
IF 2.3 Q2 SPORT SCIENCES Pub Date : 2024-07-09 DOI: 10.1016/j.smhs.2024.07.001
Guilherme Corrêa de Araújo Moury Fernandes , Ewerton Borges de Souza Lima , Paulo Henrique Schmidt Lara , Ana Camila de Castro Gandolfi , Jorge Roberto Pagura , Gustavo Gonçalves Arliani , Moisés Cohen
This study aimed to investigate the incidence and other significant features of craniomaxillofacial trauma (CMFT), particularly Sport-Related Concussion (SRC), among professional soccer players from two major leagues in Brazil. This is a prospective epidemiological study which assessed two divisions of the national championship and large regional one over four seasons. Data were gathered from soccer clubs and their medical staff using two online forms. Data related to players (age and position) and injuries (diagnosis, type, body location, laterality, field location, tests performed, need for surgery, time lost in sports, and recurrence) were collected. Between 2016 and 2019, a total of 15 seasons, comprising 3 828 matches and 126 ​324 hours (h) of gameplay, were analyzed. A total of 299 CMFT cases were reported, with a median incidence of 2.37 per 1 000 ​h of play. Among them, there were 178 head and 121 face traumas, which led to 87 SRC (representing 29.10% of all CMFT), with an incidence of 0.69. Defensive midfielders (14.43%) and goalkeepers (14.00%) had the highest prevalence rates of CMFT. Only 3.68% of the injuries, mostly lacerations and fractures, required surgical treatment. This study identified that the average time lost in sports due to SRC was 5.12 days, with a recurrence rate of 12.71%. SRC are a frequent consequence of CMFT in Brazilian professional soccer. Although most cases are mild, there is a high recurrence rate, which may have long-term implications.
本研究旨在调查巴西两个主要联赛的职业足球运动员颅颌面外伤(CMFT)的发生率和其他重要特征,特别是运动相关脑震荡(SRC)。这是一项前瞻性流行病学研究,评估了四个赛季中全国锦标赛和大型地区锦标赛的两个部门。数据是通过两种在线表格从足球俱乐部及其医务人员那里收集的。收集与球员(年龄和位置)和损伤(诊断、类型、身体位置、侧边、场地位置、进行的测试、手术需求、运动中损失的时间和复发)相关的数据。在2016年至2019年期间,共分析了15个赛季,包括3828场比赛和126 324小时的游戏时间。报告了299例CMFT病例,中位发病率为每1000小时2.37例。其中头部外伤178例,面部外伤121例,导致SRC 87例(占全部CMFT的29.10%),发生率为0.69。防守中场球员(14.43%)和守门员(14.00%)的CMFT患病率最高。只有3.68%的损伤需要手术治疗,主要是撕裂伤和骨折。本研究发现,SRC导致的平均运动时间损失为5.12天,复发率为12.71%。SRC是巴西职业足球中CMFT的常见后果。虽然大多数病例是轻微的,但复发率高,这可能有长期的影响。
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引用次数: 0
Combined effects of Tai-Chi gait with mediolateral ground support perturbation on dynamic balance control 太极步态与内外侧地面支撑扰动对动态平衡控制的综合影响
IF 2.3 Q2 SPORT SCIENCES Pub Date : 2024-07-09 DOI: 10.1016/j.smhs.2024.07.002
Jacob Smith , Troilyn Jackson , Wei Liu , Jonathan Gelfond , Hao-Yuan Hsiao
Tai-Chi (TC) is a broadly used exercise that appeared to decrease the risk of falls. However, biomechanical mechanisms underlying the reduced fall risks following TC exercise remain unclear and hinder the ability to optimize TC intervention to target specific balance deficit disorders. In addition, combining TC gait exercise with ground support perturbation may be a viable approach to further challenge balance control compared to TC gait alone. The purpose of this study was to compare dynamic stability and limb support force production during comfortable walking speed (CWS), TC gait, and TC gait with medial (MED) and lateral (LAT) ground support perturbations in older and younger adults. Ten older adults and ten younger adults performed CWS, TC gait, LAT, and MED. Conditions involving TC gait showed decreased margin of stability (MoS) (main effect of condition, p ​< ​0.01) and increased vertical force impulse compared to CWS (p ​< ​0.01). Medial ground support perturbation induced the smallest MoS among all conditions. Older adults showed increased MoS compared to younger adults (p ​< ​0.01). These findings provided insight into how key balance control characteristics are modulated during TC exercise and indicate that combining ground support perturbation with TC may further challenge dynamic stability.
太极拳(TC)是一种广泛使用的运动,似乎可以降低跌倒的风险。然而,降低TC运动后跌倒风险的生物力学机制尚不清楚,并阻碍了优化TC干预以针对特定平衡缺陷障碍的能力。此外,与单独的TC步态相比,将TC步态运动与地面支撑扰动相结合可能是进一步挑战平衡控制的可行方法。本研究的目的是比较老年人和年轻人在舒适步行速度(CWS)、TC步态和具有内侧(MED)和外侧(LAT)地面支持扰动的TC步态时的动态稳定性和肢体支配力产生。10名老年人和10名年轻人进行了CWS、TC步态、LAT和MED测试。涉及TC步态的条件显示稳定裕度(MoS)下降(条件的主要影响,p <;0.01),与CWS相比垂直力冲量增加(p <;0.01)。在所有条件下,中间地面支撑扰动引起的最小最小损失。与年轻人相比,老年人的MoS增加(p <;0.01)。这些发现揭示了关键平衡控制特性在TC运动中是如何被调节的,并表明地面支撑扰动与TC的结合可能进一步挑战动态稳定性。
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引用次数: 0
Corticospinal tract alterations after ankle sprain in adolescence: Insights from the mouse model 青春期踝关节扭伤后皮质脊髓束的改变:小鼠模型的启示
IF 2.3 Q2 SPORT SCIENCES Pub Date : 2024-06-16 DOI: 10.1016/j.smhs.2024.06.006
Xiao'ao Xue , Xicheng Gu , Yuwen Zhang , Xuejun Wu , Tian Xia , Rong Lu , He Wang , Yinghui Hua

Purpose

Lateral ankle sprains (LAS) are associated with corticospinal pathway deficits. Existing evidence is primarily based on cross-sectional investigations and noncausal speculations. This study aims to determine whether maladaptive corticospinal pathway alterations occur pre- and postligament transection in LAS mouse models. Additionally, this study explores whether the alterations are more pronounced in adolescent mice than adults.

Methods

Twenty-four 8-week-old adolescent and twenty-four 24-week-old adult mice were randomly assigned to lateral ankle ligament transection or sham surgery. Diffusion-weighted imaging of the corticospinal pathway was performed presurgery and 8 weeks postsurgery. Fractional anisotropy (FA) values, reflecting fiber integrity within the corticospinal subregions of the medulla, pons, midbrain, and cerebrum, were extracted.

Results

Overall, 41 mice completed repeated image acquisition. Before surgery, no significant group effects on FA within the four corticospinal subregions were detected in either adolescent or adult mice. Two months after surgery, the adolescent cohort displayed a significant reduction in FA in the medulla subregion following ankle ligament transection (β-baseline-adjusted ​= ​−0.083, 95% CI, −0.145 to −0.021, p-corrected ​= ​0.048). Conversely, no significant effects of ankle ligament transection on corticospinal FA were observed in the adult cohort.

Conclusion

The maladaptive alterations in the corticospinal tract could be observed in the adolescent LAS mouse model, characterized by reduced fiber integrity in the medulla subregion. While these results are derived from an animal model, they provide a foundation for future investigations into the mechanisms underlying neurological deficits following musculoskeletal injuries.
目的:外侧踝关节扭伤(LAS)与皮质脊髓通路缺陷有关。现有的证据主要是基于横断面调查和非因果推测。本研究旨在确定LAS小鼠模型中韧带横断前和韧带横断后是否会发生适应性不良的皮质脊髓通路改变。此外,本研究还探讨了这种变化在青春期小鼠中是否比成年小鼠更明显。方法将24只8周龄的青春期小鼠和24只24周龄的成年小鼠随机分为踝关节外侧韧带横断组和假手术组。术前和术后8周对皮质脊髓通路进行弥散加权成像。提取分数各向异性(FA)值,反映髓质、脑桥、中脑和大脑皮质脊髓亚区纤维的完整性。结果41只小鼠完成了重复图像采集。手术前,在青春期或成年小鼠中,未检测到四个皮质脊髓亚区对FA的显著组效应。手术后两个月,青少年队列显示踝关节韧带横断后髓质亚区FA显著减少(β-基线校正= - 0.083,95% CI, - 0.145至- 0.021,p校正= 0.048)。相反,在成人队列中没有观察到踝关节韧带横断对皮质脊髓FA的显著影响。结论青少年LAS小鼠模型存在皮质脊髓束的不适应改变,表现为髓质亚区纤维完整性降低。虽然这些结果来自动物模型,但它们为未来研究肌肉骨骼损伤后神经功能缺陷的机制提供了基础。
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引用次数: 0
Model for predicting metabolic activity in athletes based on biochemical blood test analysis 基于血液生化测试分析的运动员代谢活动预测模型
IF 2.3 Q2 SPORT SCIENCES Pub Date : 2024-06-08 DOI: 10.1016/j.smhs.2024.06.005
Victoria A. Zaborova , Evgenii I. Balakin , Ksenia A. Yurku , Olga E. Aprishko , Vasiliy I. Pustovoyt
Improving the efficiency of athletic performance and reducing the likelihood of overtraining are primarily determined goals that can be achieved by the correct organization of the training process. The nature of adaptation to physical stress is associated with the specificity, focus, and degree of biochemical and functional changes that occur during muscular work. In this study, we aimed to develop a diagnostic model for predicting metabolic processes in athletes based on standard biochemical blood analysis indicators. The study involved athletes from the track and field athletics team (men, n ​= ​42, average age was [22.55 ​± ​3.68] years). Blood samples were collected in the morning at the beginning and end of the training week during the annual cycle. During the entire period, 3 625 laboratory parameter tests were conducted. Capillary blood sampling in athletes was conducted from the distal phalanx of the finger after overnight fasting, according to standard diagnostic procedures. To determine the predominance of anabolic or catabolic processes, equations were derived from a linear discriminant function. The discriminant function of predicting metabolic processes in athletes has a high information capacity (92.1%), as confirmed by the biochemical results of neuroendocrine system activity, which characterized the body's stage of adaptive regulatory mechanisms in response to stress factors. The classification matrix used to predict the metabolic processes based on the results of the discriminant function calculation demonstrates the statistical significance of the model (p ​< ​0.01). Consequently, an informative mathematical model was developed, which enabled the reliable and timely prediction of the prevalence of one of the metabolic activity phases in the athlete's body. The use of the developed model will also allow us to assess the nature of adaptation to specific muscular work, identify an athlete's weaknesses, forecast the success of their performance, and timely adjust both the training process and the recovery program.
提高运动表现的效率和减少过度训练的可能性是可以通过正确组织训练过程来实现的主要确定目标。适应物理应激的性质与肌肉工作过程中发生的生化和功能变化的特异性、焦点和程度有关。在这项研究中,我们旨在建立一个基于标准生化血液分析指标预测运动员代谢过程的诊断模型。研究对象为田径队运动员,男性42人,平均年龄[22.55±3.68]岁。在年度周期中,于训练周开始和结束时的早晨采集血样。在整个期间,进行了3 625次实验室参数测试。根据标准诊断程序,在禁食一夜后,从运动员的手指远端指骨进行毛细血管血液采样。为了确定合成代谢或分解代谢过程的优势,从线性判别函数推导出方程。神经内分泌系统活动的生化结果证实,预测运动员代谢过程的判别函数具有较高的信息容量(92.1%),表征了机体对应激因素的适应性调节机制的阶段。基于判别函数计算结果,用于预测代谢过程的分类矩阵证明了模型的统计显著性(p <;0.01)。因此,开发了一个信息丰富的数学模型,能够可靠和及时地预测运动员体内某一代谢活动阶段的流行情况。使用已开发的模型还将使我们能够评估对特定肌肉工作的适应性质,确定运动员的弱点,预测他们表现的成功,并及时调整训练过程和恢复计划。
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引用次数: 0
Effects of eccentric resistance training after stroke on body function, activities of daily living and cognitive function: A review 中风后偏心阻力训练对身体功能、日常生活活动和认知功能的影响:综述
IF 2.3 Q2 SPORT SCIENCES Pub Date : 2024-06-07 DOI: 10.1016/j.smhs.2024.06.004
Maria Ramoneda-Rabat , Josep Medina-Casanovas , Maria Betina Nishishinya Aquino , Myriam Guerra-Balic
Impairments on body function, activities of daily living (ADL) and cognition are common after stroke. Eccentric resistance training (ERT) may be implemented to improve them.
The primary objectives were to evaluate whether ERT improves body function, ADL and cognition after stroke. The secondary objectives were to evaluate whether ERT improves strength, gait, quality of life, and self-perceived health.
Seven electronic databases were searched: Cochrane Central Register of Controlled Trials, Cochrane Stroke Group Trials Register, PubMed, Epistemonikos, Embase, SPORTDiscus, and WHO International Clinical Trials Registry Platform. Last search was run in December 2023, including studies since 2012.
Selection criteria were studies with stroke participants of both sexes, aged 18 or more, with an intervention based on ERT. Accepted languages were English, Spanish or French.
First search was done in pairs. Authors removed duplicate studies and those which did not meet inclusion criteria through title and abstracts. Finally, all authors, independently, screened the final search results and extracted data.
Of 68 records identified, 15 were eligible and 6 were finally included (with moderate risk of bias), analyzing 159 participants. Body function (4 interventions, n ​= ​84), gait (4 interventions, n ​= ​115) and strength (3 interventions, n ​= ​78) showed significantly better results when ERT was performed. Meta-analysis could not be done because of the few studies and their heterogeneity.
This review provided low-moderate quality evidence suggesting that ERT might be effective at improving body function, strength, and gait after stroke. Besides, no harm was documented, and it was well-accepted.
脑卒中后身体功能、日常生活活动和认知功能的损害是常见的。可以实施偏心阻力训练(ERT)来改善它们。主要目的是评估ERT是否能改善脑卒中后的身体功能、日常生活能力和认知能力。次要目的是评估ERT是否能改善力量、步态、生活质量和自我感知健康。检索了7个电子数据库:Cochrane中央对照试验注册库、Cochrane卒中组试验注册库、PubMed、Epistemonikos、Embase、SPORTDiscus和WHO国际临床试验注册平台。最后一次搜索是在2023年12月,包括2012年以来的研究。选择标准是对18岁或以上的卒中参与者进行研究,干预基于ERT。接受的语言是英语、西班牙语或法语。第一次搜索是成对进行的。作者通过标题和摘要删除了重复研究和不符合纳入标准的研究。最后,所有作者独立筛选最终搜索结果并提取数据。在确定的68条记录中,15条符合条件,6条最终纳入(具有中等偏倚风险),分析了159名参与者。进行ERT治疗后,身体功能(4项干预,n = 84)、步态(4项干预,n = 115)和力量(3项干预,n = 78)均有明显改善。由于研究较少且具有异质性,因此无法进行meta分析。本综述提供了中低质量的证据,表明ERT可能有效改善中风后的身体功能、力量和步态。此外,没有任何危害被记录下来,并且被广泛接受。
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引用次数: 0
Impact of COVID-19 pandemic on cardiovascular health in sedentary and athletes: Consensus, uncertainties, and ways for mitigation COVID-19 大流行对久坐不动者和运动员心血管健康的影响:共识、不确定性和缓解方法
IF 2.3 Q2 SPORT SCIENCES Pub Date : 2024-06-06 DOI: 10.1016/j.smhs.2024.06.003
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引用次数: 0
Effects of COVID-19 on the cardiovascular system: A mendelian randomization study COVID-19 对心血管系统的影响:孟德尔随机化研究
IF 2.3 Q2 SPORT SCIENCES Pub Date : 2024-06-04 DOI: 10.1016/j.smhs.2024.06.001

Infections with the coronavirus disease 2019 (COVID-19) and disorders of the heart and blood vessels are causally related. To ascertain the causal relationship between COVID-19 and cardiovascular disease (CVD), we carried out a Mendelian randomization (MR) study through a method known as inverse variance weighting (IVW). When analyzing multiple SNPs, MR can meta-aggregate the effects of multiple loci by using IVW meta-pooling method. The weighted median (WM) is the median of the distribution function obtained by ranking all individual SNP effect values according to their weights. WM yields robust estimates when at least 50% of the information originates from valid instrumental variables (IVs). Directed gene pleiotropy in the included IVs is permitted because MR–Egger does not require a regression straight line through the origin. For MR estimation, IVW, WM and MR-Egger were employed. Sensitivity analysis was conducted using funnel plots, Cochran's Q test, MR–Egger intercept test, MR–PRESSO, and leave-one-out analysis. SNPs related to exposure to COVID-19 and CVD were compiled. CVD for COVID-19 infection, COVID-19 laboratory/self-reported negative, and other very severe respiratory diagnosis and population were randomly assigned using MR. The COVID-19 laboratory/self-reported negative results and other very severe respiratory confirmed cases versus MR analysis of CVD in the population (p ​> ​0.05); COVID-19 infection to CVD (p ​= ​0.033, OR ​= ​1.001, 95%CI: 1.000–1.001); and the MR–Egger results indicated that COVID-19 infection was associated with CVD risk. This MR study provides preliminary evidence for the validity of the causal link between COVID-19 infection and CVD.

2019年冠状病毒病(COVID-19)感染与心脏和血管疾病存在因果关系。为了确定 COVID-19 与心血管疾病(CVD)之间的因果关系,我们通过一种称为逆方差加权(IVW)的方法进行了孟德尔随机化(MR)研究。在分析多个 SNPs 时,MR 可通过 IVW 元池化法对多个位点的效应进行元聚合。加权中值(WM)是根据所有单个 SNP 效应值的权重进行排序后得到的分布函数的中值。当至少 50%的信息来源于有效的工具变量(IVs)时,加权中值会产生稳健的估计值。由于 MR-Egger 不要求通过原点的回归直线,因此允许在所包含的 IV 中存在定向基因多向性。MR 估计采用了 IVW、WM 和 MR-Egger。使用漏斗图、Cochran's Q 检验、MR-Egger 截距检验、MR-PRESSO 和leave-one-out 分析进行了敏感性分析。汇编了与 COVID-19 暴露和心血管疾病相关的 SNPs。COVID-19感染的心血管疾病、COVID-19实验室/自我报告阴性以及其他非常严重的呼吸系统诊断和人群使用MR进行随机分配。COVID-19 实验室/自报阴性结果和其他非常严重的呼吸道确诊病例与 MR 分析人群的心血管疾病相关(p > 0.05);COVID-19 感染与心血管疾病相关(p = 0.033,OR = 1.001,95%CI:1.000-1.001);MR-Egger 结果表明,COVID-19 感染与心血管疾病风险相关。这项 MR 研究为 COVID-19 感染与心血管疾病之间因果关系的有效性提供了初步证据。
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Sports Medicine and Health Science
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