Human Nutrition and Metabolism最新文献

Background

The present study aimed to explore the association of vitamin D with triglyceride-glucose (TyG) index and cardiometabolic risk factors in subclinical hypothyroidism (SCH).

Methods

We recruited 75 individuals diagnosed with SCH and 75 healthy controls of both genders aged 20 to 65 years. Triiodothyronine (T₃), thyroxine (T₄), thyroid stimulating hormone (TSH) and 25-hydroxyvitamin D [25(OH)D] were measured using chemiluminescent immunoassay. Fasting plasma glucose and lipid profile were analyzed by standard methods. The TyG index was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)]/2.

Results

There were significant decreases in 25(OH)D levels and changes in cardiometabolic risk factors among individuals with SCH compared to healthy controls. Additionally, there was a significant increase in the TyG index among the SCH group. Correlation and regression analysis revealed that 25(OH)D was significantly and negatively associated with TyG index, diastolic blood pressure (DBP), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C). However, it was positively associated with high-density lipoprotein cholesterol (HDL-C).

Conclusion

Present study shows that SCH patients have lower vitamin D levels and higher TyG index, increasing cardiovascular disease risk. Screening and managing vitamin D deficiency is crucial in these subjects. In addition, TyG index could be used as an indicator for identifying vitamin D deficiency.

Purpose

The current study sought to assess the synergistic effects of an eight-week nutrition education program (NEP) and controlled dietary modification (CDM) on the nutrition knowledge (NK), nutrition practice (NP), and daily dietary intake of nutrition counselling group (NCG) versus ad-libitum group (ALG), as well as to identify the dietary factors predicting athletes' NP.

Methods

A total of 105 male players (14–18 years) from the sports disciplines-football, hockey, swimming, and athletics-were block randomized into the NCG and the ALG. The NCG underwent an 8-week nutritional intervention (NI) that included NEP and CDM, while ALG did not participate in the NI and followed ad-libitum dietary intake. Primary data on each subject's NK, NP, daily food intake, and anthropometric measurements were collected before and after the intervention period for paired and case-control analysis.

Results

A strong association has been depicted between players’ NK and NP. Daily intake of carbohydrate, protein, calcium, and dietary fibre could be referred to as the significant positive predictors of NP, while fat intake is the negative predictor. The synergistic implementation of NEP and CDM reduced the energy deficits among the NCGby significantly increasing their daily calorie intake to an average of 97%. Protein intake was significantly increased, thus meeting 88% of the recommendation, while the increase in carbohydrate intake was insignificant, meeting 89% of the standards post-NI. Further, the NCG showed significant increases in intake of minerals like calcium, phosphorus, iron, zinc, and selenium, while the ALG had substantial reductions. The former also exhibited significant rises in vitamin A, B9, B12, C, and E intakes. The most significant spikes in macro and micronutrient intake were observed in the footballers and hockey players, who were also the groups with the largest increases in NK and NP scores.

Conclusion

The equilibrium in macronutrient bifurcations and relative macronutrient and micronutrient intake post-intervention indicates the effectiveness of nutritional enactment through an 8-week controlled dietary modification and systematic nutrition education programme on the nutritional status of young athletes. Therefore, good nutrition knowledge may improve the dietary patterns and nutrition intake of athletes. Intervention studies should emphasize nutrition education, aiming for improved athletic performance.

Intermittent fasting (IF) has garnered attention for its potential to promote health and combat chronic diseases. This study focused on the effects of Ramadan fasting, a form of IF observed by Muslims, on renal and liver function markers, anthropometric measurements, and dietary intake in healthy overweight and obese men. The study involved 60 participants from Hargeisa, Somaliland, with an average age of 40.01 ± 7.99 years. Results revealed significant reductions in body weight (P ≤ 0.001), waist circumference (P ≤ 0.001), and body mass index (P ≤ 0.001) after Ramadan fasting. Urea levels decreased significantly (P = 0.003), and though creatinine levels showed a non-significant decrease, uric acid levels increased significantly within the normal range (P ≤ 0.001). Serum glutamate oxaloacetate transaminase (GOT) levels decreased significantly (P ≤ 0.001), while glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels remained stable. Dietary analysis indicated a significant decrease in total carbohydrates (P = 0.023), proteins (P = 0.006), and dietary cholesterol intake (P ≤ 0.001). These findings suggest that Ramadan fasting positively impacts anthropometric and renal-liver function markers in healthy overweight and obese men. The study contributes to the expanding understanding of intermittent fasting's potential health benefits, emphasizing the importance of considering Ramadan fasting as a preventive approach for metabolic disorders. Further research should explore long-term effects, mechanistic insights, and personalized clinical applications, while public health initiatives could educate individuals about safe and informed fasting practices.

The aim of the study was to evaluate the effectiveness of a school-based intervention programme among overweight and obese adolescents in Seremban, Negeri Sembilan, Malaysia. A cluster randomised controlled trial was conducted to evaluate the effect of the intervention (n = 200) and compared with control group (n = 200). The intervention was developed based on social cognitive theory, conducted in a group based, five-session of face-to-face, bi-weekly for 10 weeks. The primary outcomes were body mass index (BMI) and BMI-for-age z-scores (BAZ), whereas the secondary outcomes were breakfast consumption, physical activity level, self-efficacy, and body satisfaction. T-tests and generalized linear mixed model analysis were used to examine the effectiveness of the intervention at baseline, immediate post-intervention, and 3-month post-intervention, while controlling for covariates. A significant intervention effect was found in reducing BMI and BAZ. BMI of the participants in the intervention group was reduced from 28.10 kg/m² to 27.93 kg/m², and further decreased to 27.80 kg/m², while BAZ was reduced from 2.19 to 2.12, and further decreased to 2.07, from baseline to immediate post-intervention, and 3-month follow-up, respectively. Furthermore, there was significant improvement in breakfast consumption frequency, physical activity scores, healthy eating and weight self-efficacy scores, perceived physical activity self-efficacy scores, and body discrepancy scores as compared with the control group. The integrated school-based intervention programme was effective in reducing BMI and BAZ among overweight and obese participants. The results suggested that this programme could be integrated as one of the regular school co-curricular programmes.

Background

In Sub-Saharan African countries, data examining postmenopausal women's cardiometabolic risk (CMR) remains limited. Our study aimed to assess the visceral adiposity index (VAI) and lipid accumulation product (LAP), atherogenic index of plasma (AIP), and physical activity levels of postmenopausal women and determine their CMR.

Methods

A cross-sectional study included 224 postmenopausal women aged ≥47 years recruited from Khartoum State, Sudan. Weight, height, waist and hip circumferences were measured. Physical activity levels were determined using the Global Physical Activity Questionnaire version 2. Fasting blood samples (5 mL) were collected to determine the lipid profile. The VAI and LAP were calculated as indicators for visceral adiposity, whereas AIP was calculated as an indicator of CVD risk.

Results

The postmenopausal women's mean age was 62.4 ± 10.2 years. Women (29.2%; 54/185) were physically inactive, with most inactive women being >64 years and having ≥5 CVD risk factors compared with the active and very active women with 3–4 CVD risk factors. Women had high total cholesterol (24.6%), triglycerides (26.6%), low-density lipoprotein cholesterol (14.3%), and low high-density lipoprotein cholesterol (61.2%) levels. Moreover, women (33.5%) had a high CVD risk. In multiple regression analyses, AIP increased significantly with VAI and BMI. The ROC analysis revealed that the highest and statistically significant AUC was recorded for VAI followed by LAP among postmenopausal women, suggesting their diagnostic significance for CVD risk.

Conclusion

VAI and LAP were closely associated with an increased risk of CVD in postmenopausal Sudanese women and were considered the best diagnostic performance.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has four structural proteins. Inside human host cell, it replicates, for which each requires all the structural proteins, and to generate these, entire requirement of amino acids is borne by the host. There is no data regarding amino acid profiling, variation in strains, and its actual burden on the human host. Profiling, with its therapeutic utility, was studied using genomics and proteomics of earliest Wuhan strain and was compared with the recent emerging heavily mutated variant of concern, Omicron. With each replicating SARS-CoV-2 consuming a considerable percentage of essential amino acids (EAAs), coronavirus infection causes huge burden of EAAs on the entire human body in generating billions and billions of SARS-CoV-2 and can cause depletion of body protein stores. The complete amino acid profiling of the structural proteins of SARS-CoV-2 can act as benchmark for designing the correct nutritional supplements for the management of nutritional burden on the patients with SARS-CoV-2 infection.

Road traffic collisions are the commonest cause of traumatic brain injury (TBI). Patients with brain injury may present with a wide range of symptoms depending on nature and types of injury. Generally, severity of TBI can be classified into mild, moderate and severe based on Glasgow Coma Scale (GCS). This scoring system objectively describes the extent of impaired consciousness. Score of 8 or below indicates severe TBI and will require admission to intensive care and mechanical ventilation. These patients experience significant metabolic changes as a result of excessive production of endogenous catabolic hormones following the injury. Nutritional requirements among these patients differ based on severity of trauma and phase of illness. Timely initiation of feed and addressing individualised nutritional needs can prevent malnutrition. Apart from that, nutrition plays a very important role in neuronal recovery and directly affects neuronal plasticity thus the prognosis. Early involvement of nutritional support as a part of comprehensive care is the key to recovery and better outcome. The aim of this review is to provide an overview of the current evidence-based nutrition therapy for patients with TBI in critical care settings. The review covers the energy and nutrient requirements, enteral and parenteral nutrition, and challenges associated with it.

Bone mineral density (BMD), which is used to assess bone health, is often diminished in chronic disease states, such as diabetes, which increases the risk of bone fracture. The circulating vitamin C and 25-hydroxy-vitamin D levels are commonly lower in diabetic patients. Vitamin D is implicated in bone formation, while vitamin C has been shown to inhibit osteoclastic activity. Vascular cell adhesion molecule-1 (VCAM-1) promotes osteoclastic activity and bone loss. This study investigated whether any association exists between vitamin C and vitamin D status and BMD and VCAM-1 levels in female diabetic subjects (n = 65). 25-hydroxy-vitamin D had no significant relationship with either BMD or VCAM-1 levels. However, vitamin C showed a significant positive association with BMD and a negative association with VCAM-1. This suggests that combined supplementation with vitamin D and vitamin C, rather than supplementation with vitamin D alone, could be a better strategy for the improvement of bone health and thus deserves further investigation.

Purpose

This work aimed to study postpartum mental outcomes and determinants of the intake of caffeinated beverages during the pandemic in women from Argentina.

Methods

This cross-sectional study recruited 619 women who responded to online self-report questionnaires during the first and second waves of COVID-19, including validated instruments (Insomnia Severity Index, Perceived Stress Scale, Postpartum Depression Screening Scale, Memory Complaint Scale, and Breastfeeding Self-Efficacy Scale), and general data. Intake frequency and amount of caffeinated beverages were estimated. Multivariate regression and structural equation models identified associations and effects (p < 0.05).

Results

Women were under social restrictions for 60.39 days, with home and essential activities increasing caffeinated intake. They ingested (mL/d): yerba mate (1457.71), coffee (66.85), tea (67.61), and soft drinks (50.95), which provided 646.20 mg/d of caffeine. Intakes of coffee and yerba mate were higher than pre-pandemic ones. Coffee was positively associated with stress and insomnia, and indirectly linked to higher levels of depression and memory complaints, and lower breastfeeding self-efficacy. Tea showed a similar but weaker association. Yerba mate correlated inversely with depression (through direct pathways), insomnia, and memory complaints (through indirect pathways), promoting breastfeeding self-efficacy. Soft drinks and caffeine did not present significant associations.

Conclusion

Although findings do not imply causation, results suggest that beverages would exhibit caffeine-independent affective and cognitive roles, which might be anxiogenic in the case of coffee and tea (to a lesser extent). Yerba mate showed antidepressant potential. Given that breastfeeding might be compromised during the pandemic, yerba mate intake is promissory to protect postpartum mental health.

Among plasma metabolites linked with a health-conscious food pattern (HCFP) identified in the Malmö Diet and Cancer epidemiological study, circulating ergothioneine (ERT) concentrations exhibited the strongest independent association with reduced risk of cardiometabolic disease and all-cause mortality and were also related to alcohol consumption. Thus, we first assessed whether alcohol intake and ERT were similarly associated in participants of the Hunter Community Study (HCS) that did not follow an HCFP-based diet. Then, we sought to identify the presence of associations with some biomarkers associated with cardiovascular disease. In a multivariable adjusted, robust regression analysis, compared to non-drinkers, safe drinkers had, on average, a serum ERT concentration 0.112 (95% CI: 0.0–0.225; P = 0.051) units higher and moderate-hazardous drinkers had a serum ERT concentration 0.240 (95% CI: 0.093–0.387; P = 0.001) units higher. Moreover, stepwise multiple linear regression shows that age (P = 0.025), and asymmetric dimethyl-l-arginine (ADMA) (P = 0.001) were independently associated with serum ERT concentrations, independently of age, sex, education, household income, marital status, and health status of participants, or possible alcohol-induced organ damage. The relationship between ERT and ADMA offers a potential explanation for the interplay between ERT, and decreased risk of cardiometabolic disease and all-cause mortality. Also, it provides new mechanistic insights into the association between alcohol consumption and cardiovascular diseases, possibly mediated by ADMA metabolic pathways.