Considering the pivotal role of diet and microbiome in modulating the disease's severity and progression in patients with ulcerative colitis (UC), we performed a cross-sectional study to elucidate the link between the Sulfur microbial diet (SMD) score and the clinical course of UC.
Methods
158 patients with UC were enrolled. An expert gastroenterologist reported the disease severity using the Mayo score. An expert nutritionist recorded the amount and frequency of intake of 168 food items by the valid Food Frequency Questionnaire (FFQ). The method introduced by Nguyen et al. was used to calculate SMD score. The association between disease severity and adapted SMD score was analyzed by the logistic regression adjusting for dietary factors, demographic values, and lifestyle factors.
Results
The mean age of participants was 42.52 ± 12.61 years old and there were no significant differences in baseline information of patients in different adapted SMD score tertiles except for protein intake. There were significant differences in dietary intake of all components across the tertile of the adapted SMD score except for processed meat (p = 0.97). In the fully adjusted model, the odds of severe disease were 4.29 times higher in the patients in the third tertile of the adapted SMD score compared with the first tertile (OR: 4.29, 95 %CI: 1.42, 12.91).
Conclusions
The higher score of adapted SMD was associated with higher severity of UC. However, due to the limitations of this study, more longitudinal and clinical trials considering the different confounders should be undertaken to improve this conclusion.
{"title":"There was an association between sulfur microbial diet score and ulcerative colitis severity: the result of a cross-sectional study","authors":"Zeinab Nikniaz , Reza Mahdavi , Zahra Bakhtiari , Kourosh Masnadi Shirazi","doi":"10.1016/j.hnm.2025.200333","DOIUrl":"10.1016/j.hnm.2025.200333","url":null,"abstract":"<div><h3>Background</h3><div>Considering the pivotal role of diet and microbiome in modulating the disease's severity and progression in patients with ulcerative colitis (UC), we performed a cross-sectional study to elucidate the link between the Sulfur microbial diet (SMD) score and the clinical course of UC.</div></div><div><h3>Methods</h3><div>158 patients with UC were enrolled. An expert gastroenterologist reported the disease severity using the Mayo score. An expert nutritionist recorded the amount and frequency of intake of 168 food items by the valid Food Frequency Questionnaire (FFQ). The method introduced by Nguyen et al. was used to calculate SMD score. The association between disease severity and adapted SMD score was analyzed by the logistic regression adjusting for dietary factors, demographic values, and lifestyle factors.</div></div><div><h3>Results</h3><div>The mean age of participants was 42.52 ± 12.61 years old and there were no significant differences in baseline information of patients in different adapted SMD score tertiles except for protein intake. There were significant differences in dietary intake of all components across the tertile of the adapted SMD score except for processed meat (p = 0.97). In the fully adjusted model, the odds of severe disease were 4.29 times higher in the patients in the third tertile of the adapted SMD score compared with the first tertile (OR: 4.29, 95 %CI: 1.42, 12.91).</div></div><div><h3>Conclusions</h3><div>The higher score of adapted SMD was associated with higher severity of UC. However, due to the limitations of this study, more longitudinal and clinical trials considering the different confounders should be undertaken to improve this conclusion.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200333"},"PeriodicalIF":1.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-19DOI: 10.1016/j.hnm.2025.200328
Tao Yu , Shu Zhang , Ryota Wakayama , Tomohito Horimoto , Chikako Tange , Yukiko Nishita , Rei Otsuka
Background
The serum 25-hydroxyvitamin D (25OHVD) insufficiency is a recognized public health nutrition concern globally. The relationship between dietary factors and serum 25OHVD levels remains unclear in the Japanese population.
Objective
This study aimed to evaluate diet quality using the Meiji Nutritional Profiling System (Meiji NPS) and investigated its cross-sectional association with serum 25OHVD levels in Japanese middle-aged and older adults.
Methods
Data were analyzed from 1272 middle-aged adults and 873 older adults participating in the National Institute for Longevity Sciences - Longitudinal Study of Aging in Japan. Participants with complete dietary records and serum 25OHVD measurements were included. Diet quality was assessed using the Meiji NPS, and a dietary index was calculated for each individual. Associations between diet quality and serum 25OHVD levels were examined using general linear model adjusted for various covariates.
Results
The median age, dietary index, and prevalence of serum 25OHVD insufficiency (<30 ng/ml) were 53 years, 10.1 points, and 74.2 % in adults, and 73.0 years, 12.0 points, and 60.5 % in older adults, respectively. Higher dietary indices were positively associated with serum 25OHVD levels in both adults (partial regression coefficient 0.11; 95 % confidence interval: 0.04–0.18), and older adults (0.17, 0.07–0.26).
Conclusions
This study suggests a positive association between diet quality, as evaluated by the Meiji NPS, and serum 25OHVD levels in middle-aged and older adults.
{"title":"Association between diet quality evaluated using the Meiji nutritional profiling system and serum 25-hydroxyvitamin D levels in Japanese adults and older adults: A cross-sectional study from the NILS-LSA","authors":"Tao Yu , Shu Zhang , Ryota Wakayama , Tomohito Horimoto , Chikako Tange , Yukiko Nishita , Rei Otsuka","doi":"10.1016/j.hnm.2025.200328","DOIUrl":"10.1016/j.hnm.2025.200328","url":null,"abstract":"<div><h3>Background</h3><div>The serum 25-hydroxyvitamin D (25OHVD) insufficiency is a recognized public health nutrition concern globally. The relationship between dietary factors and serum 25OHVD levels remains unclear in the Japanese population.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate diet quality using the Meiji Nutritional Profiling System (Meiji NPS) and investigated its cross-sectional association with serum 25OHVD levels in Japanese middle-aged and older adults.</div></div><div><h3>Methods</h3><div>Data were analyzed from 1272 middle-aged adults and 873 older adults participating in the National Institute for Longevity Sciences - Longitudinal Study of Aging in Japan. Participants with complete dietary records and serum 25OHVD measurements were included. Diet quality was assessed using the Meiji NPS, and a dietary index was calculated for each individual. Associations between diet quality and serum 25OHVD levels were examined using general linear model adjusted for various covariates.</div></div><div><h3>Results</h3><div>The median age, dietary index, and prevalence of serum 25OHVD insufficiency (<30 ng/ml) were 53 years, 10.1 points, and 74.2 % in adults, and 73.0 years, 12.0 points, and 60.5 % in older adults, respectively. Higher dietary indices were positively associated with serum 25OHVD levels in both adults (partial regression coefficient 0.11; 95 % confidence interval: 0.04–0.18), and older adults (0.17, 0.07–0.26).</div></div><div><h3>Conclusions</h3><div>This study suggests a positive association between diet quality, as evaluated by the Meiji NPS, and serum 25OHVD levels in middle-aged and older adults.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200328"},"PeriodicalIF":1.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recently, the digitalization of data science in nutrition has highlighted the need for comprehensive dietary databases to interpret dietary habits accurately. Previous studies have elucidated detailed profiles of amino acids (AAs) and fatty acids (FAs) in the Japanese diet beyond the general categories of proteins and lipids. This study aimed to profile the intake of AAs and FAs in the United States (U.S.) population, focusing on the quantity of these nutrients. By linking the USDA National Nutrient Database for Standard Reference with the National Health and Nutrition Examination Survey 2017–March 2020 data, we estimated the average dietary intake of 18 AAs and 19 FAs in the U.S. population, expressed in mg/1000 kcal and calculated their respective contributions. Among the 18 AAs, glutamic acid, aspartic acid, and leucine were the most consumed, accounting for 19.8 %, 9.1 %, and 8.1 % of the total intake, respectively. Among the 19 FAs, 18:1 constituted the most significant proportion at 36.5 %, followed by 18:2 at 23.3 % and 16:0 at 20.1 %. Although the intake contribution profiles of AA were similar across different food groups, those of FA varied significantly. Overall, we successfully developed a database showing the average intake of AA and FA in the U.S. population rather than focusing solely on proteins and lipids. This database provides a foundation for accurately understanding and interpreting dietary habits in the U.S. population and suggests its potential use as a reference for future international dietary comparisons.
{"title":"Analysis of dietary amino acid and fatty acid intake profiles of US adults: NHANES 2017–March 2020 Pre-pandemic","authors":"Miyu Kenzaka , Haruka Nishiyama , Miyuki Imafuku , Sae Nakao , Sari Natsume , Chika Oue , Hisami Yamanaka-Okumura","doi":"10.1016/j.hnm.2025.200329","DOIUrl":"10.1016/j.hnm.2025.200329","url":null,"abstract":"<div><div>Recently, the digitalization of data science in nutrition has highlighted the need for comprehensive dietary databases to interpret dietary habits accurately. Previous studies have elucidated detailed profiles of amino acids (AAs) and fatty acids (FAs) in the Japanese diet beyond the general categories of proteins and lipids. This study aimed to profile the intake of AAs and FAs in the United States (U.S.) population, focusing on the quantity of these nutrients. By linking the USDA National Nutrient Database for Standard Reference with the National Health and Nutrition Examination Survey 2017–March 2020 data, we estimated the average dietary intake of 18 AAs and 19 FAs in the U.S. population, expressed in mg/1000 kcal and calculated their respective contributions. Among the 18 AAs, glutamic acid, aspartic acid, and leucine were the most consumed, accounting for 19.8 %, 9.1 %, and 8.1 % of the total intake, respectively. Among the 19 FAs, 18:1 constituted the most significant proportion at 36.5 %, followed by 18:2 at 23.3 % and 16:0 at 20.1 %. Although the intake contribution profiles of AA were similar across different food groups, those of FA varied significantly. Overall, we successfully developed a database showing the average intake of AA and FA in the U.S. population rather than focusing solely on proteins and lipids. This database provides a foundation for accurately understanding and interpreting dietary habits in the U.S. population and suggests its potential use as a reference for future international dietary comparisons.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200329"},"PeriodicalIF":1.9,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food insecurity is a widespread issue that poses a major global challenge with far-reaching impacts.
Objective
Investigate the relationship between food insecurity and health behaviors among the population of Tacloban, Philippines, affected by Typhoon Haiyan in 2013.
Methods
This study employed a cross-sectional design, surveying 226 households between April 2022 and June 2023. Households were selected using a systematic random sampling technique to ensure representative coverage. To evaluate food insecurity, we utilized the Food Insecurity Experience Scale-a robust tool that captures the degree to which individuals or households face challenges in accessing sufficient and nutritious food due to economic and social constraints. In addition, we explored a variety of health-related behaviors among participants, including the use of traditional healing practices, engagement in physical activity, sleep patterns and duration, dietary habits, medication adherence, as well as alcohol and tobacco use. The relationships between food insecurity and these health behaviors were rigorously examined using multiple logistic regression analysis, providing valuable insights into the interplay between access to food and lifestyle choices within the community.
Results
The results showed that 94 % of households experienced food insecurity, with 27 % severely, 52 % moderately, and 15 % mildly food insecure. The analysis revealed significant associations between food insecurity and several health behaviors. Food insecurity was found to be significantly associated with lower medication adherence, greater use of traditional healers, poorer dietary habits, and sleeping problems. However, no significant associations were found between food insecurity and smoking behavior, physical activities, or alcohol consumption.
Conclusion
Based on these findings, the study concluded that food insecurity negatively impacts health behaviors. Therefore, the authors suggested that improving food security in households could potentially lead to improvements in health behaviors.
{"title":"Food insecurity and health behaviors in a disaster-affected population: A case study of Tacloban, Philippines","authors":"Gashaw Enbiyale Kasse , Abdo Megra Geda , Aregash Wendimu Tumebo , Elvis Akem Tambe , Abraham Belete Temesgen , Mulusew Tesfaye Yitie , Tadesse Mihiret Yimam , Samuel Atalay Shiferaw","doi":"10.1016/j.hnm.2025.200327","DOIUrl":"10.1016/j.hnm.2025.200327","url":null,"abstract":"<div><h3>Background</h3><div>Food insecurity is a widespread issue that poses a major global challenge with far-reaching impacts.</div></div><div><h3>Objective</h3><div>Investigate the relationship between food insecurity and health behaviors among the population of Tacloban, Philippines, affected by Typhoon Haiyan in 2013.</div></div><div><h3>Methods</h3><div>This study employed a cross-sectional design, surveying 226 households between April 2022 and June 2023. Households were selected using a systematic random sampling technique to ensure representative coverage. To evaluate food insecurity, we utilized the Food Insecurity Experience Scale-a robust tool that captures the degree to which individuals or households face challenges in accessing sufficient and nutritious food due to economic and social constraints. In addition, we explored a variety of health-related behaviors among participants, including the use of traditional healing practices, engagement in physical activity, sleep patterns and duration, dietary habits, medication adherence, as well as alcohol and tobacco use. The relationships between food insecurity and these health behaviors were rigorously examined using multiple logistic regression analysis, providing valuable insights into the interplay between access to food and lifestyle choices within the community.</div></div><div><h3>Results</h3><div>The results showed that 94 % of households experienced food insecurity, with 27 % severely, 52 % moderately, and 15 % mildly food insecure. The analysis revealed significant associations between food insecurity and several health behaviors. Food insecurity was found to be significantly associated with lower medication adherence, greater use of traditional healers, poorer dietary habits, and sleeping problems. However, no significant associations were found between food insecurity and smoking behavior, physical activities, or alcohol consumption.</div></div><div><h3>Conclusion</h3><div>Based on these findings, the study concluded that food insecurity negatively impacts health behaviors. Therefore, the authors suggested that improving food security in households could potentially lead to improvements in health behaviors.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200327"},"PeriodicalIF":1.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-02DOI: 10.1016/j.hnm.2025.200324
Daya Ram Pokharel , Abhishek Maskey , Ramchandra Kafle , Goma Kathayat , Binod Manandhar , Krishna Das Manandhar
Metabolic Syndrome (MetS) is a major public health concern associated with elevated risk of cardiometabolic diseases. Conventional diagnostic criteria for MetS require multiple clinical and biochemical measurements, limiting feasibility in resource-constrained settings. Novel anthropo-metabolic indices offer a simplified, surrogate approach for risk prediction and stratification. This study aimed to evaluate the diagnostic performance of the triglyceride-glucose (TyG) index, waist-triglyceride index (WTI), and their derivatives TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), and TyG-body mass index (TyG-BMI) for detecting the risk of MetS in Nepali adults.
A cross-sectional study was conducted among 1116 adults (424 females, 692 males) recruited from the premises of Manipal Teaching Hospital, Pokhara, Nepal. Baseline sociodemographic, anthropometric, and biochemical data were collected. MetS was defined using National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Indices were calculated using standard formulae and their associations with MetS were examined using Spearman's correlation, multivariable logistic regression, and receiver operating characteristic (ROC) curve analyses.
All indices demonstrated significant diagnostic capability for the detection of MetS (p < 0.001). The TyG index showed the highest overall accuracy, with area under the curve (AUC) of 0.920 in females and 0.874 in males. At optimal sex-specific cutoffs (≥8.66 for females, ≥8.87 for males), TyG demonstrated excellent sensitivity (female: 88.40 %, male: 85.55 %) and specificity (female: 88.00 %, male: 81.20 %). WTI and TyG-WC showed strong performance in identifying hypertriglyceridemia and central obesity, respectively. Logistic regression confirmed the TyG index as the strongest independent predictor of MetS (adjusted odds ratio (AOR): females = 58.59, males = 30.94, p < 0.001). Predictive accuracy was lower for hypertension and low high density lipoprotein cholesterol (HDL-C). Comparative AUC analysis revealed greater index variability among females than males.
The TyG, TyG-WC and WTI are found to be robust, gender-specific tools for diagnosis of MetS and its components in Nepali adults. Their simplicity, affordability and high diagnostic accuracy support their integration into large-scale MetS screening in resource-limited settings. Sex-specific cutoffs enhance the precision of risk assessments, emphasizing the need for tailored screening strategies.
{"title":"Diagnostic potential of waist–triglyceride index, triglyceride–glucose index and related indices for the detection of metabolic syndrome in Nepali adults: A cross-sectional study","authors":"Daya Ram Pokharel , Abhishek Maskey , Ramchandra Kafle , Goma Kathayat , Binod Manandhar , Krishna Das Manandhar","doi":"10.1016/j.hnm.2025.200324","DOIUrl":"10.1016/j.hnm.2025.200324","url":null,"abstract":"<div><div>Metabolic Syndrome (MetS) is a major public health concern associated with elevated risk of cardiometabolic diseases. Conventional diagnostic criteria for MetS require multiple clinical and biochemical measurements, limiting feasibility in resource-constrained settings. Novel anthropo-metabolic indices offer a simplified, surrogate approach for risk prediction and stratification. This study aimed to evaluate the diagnostic performance of the triglyceride-glucose (TyG) index, waist-triglyceride index (WTI), and their derivatives TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), and TyG-body mass index (TyG-BMI) for detecting the risk of MetS in Nepali adults.</div><div>A cross-sectional study was conducted among 1116 adults (424 females, 692 males) recruited from the premises of Manipal Teaching Hospital, Pokhara, Nepal. Baseline sociodemographic, anthropometric, and biochemical data were collected. MetS was defined using National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Indices were calculated using standard formulae and their associations with MetS were examined using Spearman's correlation, multivariable logistic regression, and receiver operating characteristic (ROC) curve analyses.</div><div>All indices demonstrated significant diagnostic capability for the detection of MetS (p < 0.001). The TyG index showed the highest overall accuracy, with area under the curve (AUC) of 0.920 in females and 0.874 in males. At optimal sex-specific cutoffs (≥8.66 for females, ≥8.87 for males), TyG demonstrated excellent sensitivity (female: 88.40 %, male: 85.55 %) and specificity (female: 88.00 %, male: 81.20 %). WTI and TyG-WC showed strong performance in identifying hypertriglyceridemia and central obesity, respectively. Logistic regression confirmed the TyG index as the strongest independent predictor of MetS (adjusted odds ratio (AOR): females = 58.59, males = 30.94, p < 0.001). Predictive accuracy was lower for hypertension and low high density lipoprotein cholesterol (HDL-C). Comparative AUC analysis revealed greater index variability among females than males.</div><div>The TyG, TyG-WC and WTI are found to be robust, gender-specific tools for diagnosis of MetS and its components in Nepali adults. Their simplicity, affordability and high diagnostic accuracy support their integration into large-scale MetS screening in resource-limited settings. Sex-specific cutoffs enhance the precision of risk assessments, emphasizing the need for tailored screening strategies.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200324"},"PeriodicalIF":1.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144221474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-02DOI: 10.1016/j.hnm.2025.200326
Chongyang She , Wenying Fan , Yunyun Li , Hong Lu , Mengxuan Zou
Objectives
This study investigates the association between daily nutrient intake, including antioxidants, minerals, and other essential nutrients, and cataract development in a diabetic Chinese population.
Methods
A total of 398 patients with type 2 diabetes from an urban Chinese community were recruited between January 2010 and January 2011. Participants underwent standardized evaluation, including questionnaires, ocular and anthropometric examinations, and laboratory tests. Dietary data were collected by 3-day food records. Cataract including nuclear, cortical, and posterior subcapsular cataracts (PSC), were graded according to Lens Opacities Classification System III. Multivariable logistic regressions were conducted to analyze associations between each dietary nutrient and cataract development, adjusting for social-demographic factors, lifestyle, age at onset of diabetes, and diabetes-related biomarkers in different models.
Results
Of the participants, 230 were in the cataract group, while 168 in the non-cataract group. The mean age was higher in the cataract group (68.3 ± 6.4 years) compared to non-cataract group (59.4 ± 9.4 years, P < 0.001). PSC were more severe in patients with diabetic retinopathy (P = 0.020). Dietary vitamin C was positively associated with nuclear cataracts (P < 0.05 across all models). Riboflavin (P = 0.023) and phosphorus (P = 0.026) were associated with cortical cataracts, while phosphorus (P = 0.043) and folic acid (P = 0.044) were associated with PSC cataracts. No associations were found for other nutrients.
Conclusions
Dietary vitamin C was associated with an increased risk of nuclear cataracts, while riboflavin and phosphorus were linked to cortical cataracts, phosphorus and folic acid were associated with PSC cataract. The severity of cataracts was more pronounced in patients with diabetic retinopathy.
{"title":"Association between nutrient intake and cataracts in a Chinese type 2 diabetic population","authors":"Chongyang She , Wenying Fan , Yunyun Li , Hong Lu , Mengxuan Zou","doi":"10.1016/j.hnm.2025.200326","DOIUrl":"10.1016/j.hnm.2025.200326","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigates the association between daily nutrient intake, including antioxidants, minerals, and other essential nutrients, and cataract development in a diabetic Chinese population.</div></div><div><h3>Methods</h3><div>A total of 398 patients with type 2 diabetes from an urban Chinese community were recruited between January 2010 and January 2011. Participants underwent standardized evaluation, including questionnaires, ocular and anthropometric examinations, and laboratory tests. Dietary data were collected by 3-day food records. Cataract including nuclear, cortical, and posterior subcapsular cataracts (PSC), were graded according to Lens Opacities Classification System III. Multivariable logistic regressions were conducted to analyze associations between each dietary nutrient and cataract development, adjusting for social-demographic factors, lifestyle, age at onset of diabetes, and diabetes-related biomarkers in different models.</div></div><div><h3>Results</h3><div>Of the participants, 230 were in the cataract group, while 168 in the non-cataract group. The mean age was higher in the cataract group (68.3 ± 6.4 years) compared to non-cataract group (59.4 ± 9.4 years, <em>P</em> < 0.001). PSC were more severe in patients with diabetic retinopathy (<em>P</em> = 0.020). Dietary vitamin C was positively associated with nuclear cataracts (<em>P</em> < 0.05 across all models). Riboflavin (<em>P</em> = 0.023) and phosphorus (<em>P</em> = 0.026) were associated with cortical cataracts, while phosphorus (<em>P</em> = 0.043) and folic acid (<em>P</em> = 0.044) were associated with PSC cataracts. No associations were found for other nutrients.</div></div><div><h3>Conclusions</h3><div>Dietary vitamin C was associated with an increased risk of nuclear cataracts, while riboflavin and phosphorus were linked to cortical cataracts, phosphorus and folic acid were associated with PSC cataract. The severity of cataracts was more pronounced in patients with diabetic retinopathy.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200326"},"PeriodicalIF":1.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-08DOI: 10.1016/j.hnm.2025.200321
Rabiya Zulfiqar , Kainat Fatima , Iahtisham-Ul Haq , Robert Mugabi , Aanchal Sharma , Sarvesh Rustagi , Rattan Singh , Gulzar Ahmad Nayik
Sea buckthorn (Hippophae rhamnoides L.) is a versatile plant renowned for its exceptional nutritional and therapeutic properties. Native to mountainous regions of Asia and Europe, it has been traditionally utilized for its medicinal benefits. Its promising nutritional profile highlighted by significant levels of omega-3 and omega-6 fatty acids, along with omega-7 palmitoleic acid and vitamin C content makes it unique from other plants. Omega-7 palmitoleic acid is an extremely beneficial MUFA that can be crucial in treating different metabolic disorders. Its valuable role in glucose metabolism, skin health, liver functions, inflammatory diseases etc. has been well-reported in the literature. In addition, sea buckthorn has a range of bioactive compounds like antioxidants, polyphenols, flavonoids, sugars, organic acids, vitamins, and minerals that are cardinal for added health benefits. These compounds contribute to the therapeutic potential of sea buckthorn delivering antioxidants, anti-cancer, anti-diabetic, anti-inflammatory, immune boosting and cardio-protective properties. This review sums up the chemical composition, botanical features, uses and therapeutic properties of sea buckthorn to unveil its extraordinary potential and its possible inclusion in routine therapies to improve human health its possible inclusion in routine therapies to improve human health. However, further high-quality studies are needed to firmly establish the clinical efficacy of the plant.
{"title":"The miracle Berry: Unveiling the therapeutic attributes of sea buckthorn – A review","authors":"Rabiya Zulfiqar , Kainat Fatima , Iahtisham-Ul Haq , Robert Mugabi , Aanchal Sharma , Sarvesh Rustagi , Rattan Singh , Gulzar Ahmad Nayik","doi":"10.1016/j.hnm.2025.200321","DOIUrl":"10.1016/j.hnm.2025.200321","url":null,"abstract":"<div><div>Sea buckthorn (<em>Hippophae rhamnoides</em> L.) is a versatile plant renowned for its exceptional nutritional and therapeutic properties. Native to mountainous regions of Asia and Europe, it has been traditionally utilized for its medicinal benefits. Its promising nutritional profile highlighted by significant levels of omega-3 and omega-6 fatty acids, along with omega-7 palmitoleic acid and vitamin C content makes it unique from other plants. Omega-7 palmitoleic acid is an extremely beneficial MUFA that can be crucial in treating different metabolic disorders. Its valuable role in glucose metabolism, skin health, liver functions, inflammatory diseases etc. has been well-reported in the literature. In addition, sea buckthorn has a range of bioactive compounds like antioxidants, polyphenols, flavonoids, sugars, organic acids, vitamins, and minerals that are cardinal for added health benefits. These compounds contribute to the therapeutic potential of sea buckthorn delivering antioxidants, anti-cancer, anti-diabetic, anti-inflammatory, immune boosting and cardio-protective properties. This review sums up the chemical composition, botanical features, uses and therapeutic properties of sea buckthorn to unveil its extraordinary potential and its possible inclusion in routine therapies to improve human health its possible inclusion in routine therapies to improve human health. However, further high-quality studies are needed to firmly establish the clinical efficacy of the plant.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200321"},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-08DOI: 10.1016/j.hnm.2025.200320
Saltos Atiencia Dayana , Chamba Calva Wilmer
The management of eating disorders (ED) requires a multidisciplinary approach that integrates medical, psychological, and nutritional care. In this context, Mindful Eating (ME) has emerged as a concept gaining increasing attention as a potential adjunctive approach to addressing eating disorders. The aim of this study was to analyze the scientific output related to Mindful Eating in the context of eating disorder management from 2000 to 2025, using a bibliometric analysis. The methodology followed a quantitative, descriptive, and non-experimental approach. The bibliometric study was based on a representative set of scientific articles indexed in the Scopus database. A search string was applied with filters for year, document type, and language to ensure appropriate selection. The analysis was conducted using Bibliometrix (RStudio) for bibliometric measurements and VOSviewer for generating visualizations, graphs, and data mapping. The findings revealed a significant increase in scientific production, with 91 articles published since 2008 and an annual growth rate of 17.39 %. This indicates that Mindful Eating has become a growing research theme, frequently associated with related concepts such as obesity, body weight, bulimia, anorexia, and body image. The study offers a comprehensive overview of the current research landscape, providing a foundation for future investigations into clinical applications and informing the development of hypotheses for targeted interventions.
{"title":"Mindful Eating in the management of eating disorders: A bibliometric study","authors":"Saltos Atiencia Dayana , Chamba Calva Wilmer","doi":"10.1016/j.hnm.2025.200320","DOIUrl":"10.1016/j.hnm.2025.200320","url":null,"abstract":"<div><div>The management of eating disorders (ED) requires a multidisciplinary approach that integrates medical, psychological, and nutritional care. In this context, Mindful Eating (ME) has emerged as a concept gaining increasing attention as a potential adjunctive approach to addressing eating disorders. The aim of this study was to analyze the scientific output related to Mindful Eating in the context of eating disorder management from 2000 to 2025, using a bibliometric analysis. The methodology followed a quantitative, descriptive, and non-experimental approach. The bibliometric study was based on a representative set of scientific articles indexed in the Scopus database. A search string was applied with filters for year, document type, and language to ensure appropriate selection. The analysis was conducted using Bibliometrix (RStudio) for bibliometric measurements and VOSviewer for generating visualizations, graphs, and data mapping. The findings revealed a significant increase in scientific production, with 91 articles published since 2008 and an annual growth rate of 17.39 %. This indicates that Mindful Eating has become a growing research theme, frequently associated with related concepts such as obesity, body weight, bulimia, anorexia, and body image. The study offers a comprehensive overview of the current research landscape, providing a foundation for future investigations into clinical applications and informing the development of hypotheses for targeted interventions.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200320"},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-06DOI: 10.1016/j.hnm.2025.200322
Valéria Clarisse de Oliveira , Paola Soledad Mosquera , Tamara Rodrigues dos Santos , Haroldo S. Ferreira , Bárbara H. Lourenço , Marly A. Cardoso
{"title":"Corrigendum to “Early weaning and anemia in children under 2 years old from indigenous peoples in Alagoas state, Brazil” [Hum. Nutr. Metab. 40 (2025) 200318]","authors":"Valéria Clarisse de Oliveira , Paola Soledad Mosquera , Tamara Rodrigues dos Santos , Haroldo S. Ferreira , Bárbara H. Lourenço , Marly A. Cardoso","doi":"10.1016/j.hnm.2025.200322","DOIUrl":"10.1016/j.hnm.2025.200322","url":null,"abstract":"","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200322"},"PeriodicalIF":1.8,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144766566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-03DOI: 10.1016/j.hnm.2025.200319
Samira Movahed , Farid Zayeri , Behnood Abbasi
Objective
Given that the lacto-vegetarian dietary score (LVDS), has not been previously examined in relation to formation of calcium oxalate (CaOx) kidney stones (KS), we chose to explore this potential association.
Methods
This case-control investigation involved 620 individuals, comprising 310 newly diagnosed patients with CaOx stones and 310 control subjects. Dietary consumption was evaluated through a validated 147-item food frequency questionnaire covering the previous year. The relationship between LVDs and KS was analyzed utilizing multivariable logistic regression.
Results
The results of the current study demonstrated that controls had higher mean LVDs (36.62 ± 4.74 vs 35.55 ± 5.27, P = 0.008), intake of fruits (214.31 ± 116.04 vs 196.58 ± 100.94, P = 0.043), vegetables (322.98 ± 193.89 vs 275.10 ± 154.41, P < 0.001), dairy (407.09 ± 224.24 vs 349.71 ± 222.93, P = 0.001) and olive oil (13.12 ± 2.82 vs 12.47 ± 2.09, P = 0.001) than those with CaOx KS. The univariate logistic regression results revealed that each unit increase in LVD score decreases the odds of having KS by 4.2 % (OR = 0.958, P = 0.009). After adjusting for age and BMI, the estimated OR was 0.95 for men (P = 0.013). Participants in the first tertile of LVDs had about 52 % higher odds of having KS than those in the third tertile (OR = 1.52, P = 0.04). However, a significant difference was found in male participants in the first and third tertiles of LVDs regarding the odds of having KS after adjusting for age and BMI (adjusted OR = 1.87, P = 0.02). The similar difference was not significant in female participants (OR = 0.49, P = 0.15).
Conclusion
Increasing in the LVD score is associated with a decrease in the likelihood of developing KS overall, with a more pronounced reduction in men.
考虑到乳素饮食评分（LVDS）与草酸钙（CaOx）肾结石（KS）形成的关系，我们选择探索这种潜在的联系。方法本研究共纳入620例患者，其中新诊断的CaOx结石310例，对照组310例。通过一份涵盖前一年的经过验证的147项食物频率问卷来评估饮食消费。利用多变量logistic回归分析LVDs与KS之间的关系。结果对照组LVDs（36.62±4.74 vs 35.55±5.27,P = 0.008）、水果摄入量（214.31±116.04 vs 196.58±100.94,P = 0.043）、蔬菜摄入量(322.98±193.89 vs 275.10±154.41,P <；0.001)、乳制品（407.09±224.24 vs 349.71±222.93,P = 0.001）和橄榄油（13.12±2.82 vs 12.47±2.09,P = 0.001）均高于CaOx KS组。单因素logistic回归结果显示，LVD评分每增加一个单位，发生KS的几率降低4.2% （OR = 0.958, P = 0.009）。在调整年龄和BMI后，男性的估计OR为0.95 （P = 0.013）。LVDs第一分位的参与者发生KS的几率比第三分位的参与者高52% （OR = 1.52, P = 0.04）。然而，在调整年龄和BMI后，LVDs的第一和第三十分位男性受试者发生KS的几率有显著差异（调整OR = 1.87, P = 0.02）。类似的差异在女性参与者中不显著（OR = 0.49, P = 0.15）。结论：LVD评分的增加与总体上发生KS的可能性降低有关，其中男性的降低更为明显。
{"title":"The lacto-vegetarian dietary score and kidney stones are likely to be inversely associated in men but not in women: A case-control study","authors":"Samira Movahed , Farid Zayeri , Behnood Abbasi","doi":"10.1016/j.hnm.2025.200319","DOIUrl":"10.1016/j.hnm.2025.200319","url":null,"abstract":"<div><h3>Objective</h3><div>Given that the lacto-vegetarian dietary score (LVDS), has not been previously examined in relation to formation of calcium oxalate (CaOx) kidney stones (KS), we chose to explore this potential association.</div></div><div><h3>Methods</h3><div>This case-control investigation involved 620 individuals, comprising 310 newly diagnosed patients with CaOx stones and 310 control subjects. Dietary consumption was evaluated through a validated 147-item food frequency questionnaire covering the previous year. The relationship between LVDs and KS was analyzed utilizing multivariable logistic regression.</div></div><div><h3>Results</h3><div>The results of the current study demonstrated that controls had higher mean LVDs (36.62 ± 4.74 vs 35.55 ± 5.27, P = 0.008), intake of fruits (214.31 ± 116.04 vs 196.58 ± 100.94, P = 0.043), vegetables (322.98 ± 193.89 vs 275.10 ± 154.41, P < 0.001), dairy (407.09 ± 224.24 vs 349.71 ± 222.93, P = 0.001) and olive oil (13.12 ± 2.82 vs 12.47 ± 2.09, P = 0.001) than those with CaOx KS. The univariate logistic regression results revealed that each unit increase in LVD score decreases the odds of having KS by 4.2 % (OR = 0.958, P = 0.009). After adjusting for age and BMI, the estimated OR was 0.95 for men (P = 0.013). Participants in the first tertile of LVDs had about 52 % higher odds of having KS than those in the third tertile (OR = 1.52, P = 0.04). However, a significant difference was found in male participants in the first and third tertiles of LVDs regarding the odds of having KS after adjusting for age and BMI (adjusted OR = 1.87, P = 0.02). The similar difference was not significant in female participants (OR = 0.49, P = 0.15).</div></div><div><h3>Conclusion</h3><div>Increasing in the LVD score is associated with a decrease in the likelihood of developing KS overall, with a more pronounced reduction in men.</div></div>","PeriodicalId":36125,"journal":{"name":"Human Nutrition and Metabolism","volume":"41 ","pages":"Article 200319"},"PeriodicalIF":1.9,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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