Pub Date : 2026-03-14DOI: 10.1016/j.jhazmat.2026.141775
Alessia Ore, Rick Helmus, Annemarie P. van Wezel, Nora B. Sutton
{"title":"Uncovering Redox-Specific Biotransformation of Organic Micropollutants","authors":"Alessia Ore, Rick Helmus, Annemarie P. van Wezel, Nora B. Sutton","doi":"10.1016/j.jhazmat.2026.141775","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.141775","url":null,"abstract":"","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"63 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1016/j.jhazmat.2026.141754
E. Castaño-Casco, I. Gutiérrez-Álvarez, A. Barba-Lobo, J.P. Bolívar
{"title":"Radon transport in porous materials; application to the restoration of a phosphogypsum repository","authors":"E. Castaño-Casco, I. Gutiérrez-Álvarez, A. Barba-Lobo, J.P. Bolívar","doi":"10.1016/j.jhazmat.2026.141754","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.141754","url":null,"abstract":"","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"90 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1016/j.jhazmat.2026.141714
Zhihong Guo, Min Nie, Ting Li, Changfeng Ding, Gaoxiang Huang, Zhengfu Yue, Yurong Wang, Taolin Zhang, Rong Huang, Xingxiang Wang
The Casparian strip (CS) barrier and cell wall (CW) immobilization are key defense mechanisms that limit cadmium (Cd) uptake and translocation in plant roots. However, how boron (B) influences CS formation and CW remodeling in rice roots remains poorly understood. In this study, transcriptomic, metabolomic, and anatomical analyses were combined to elucidate, for the first time, the effects and underlying mechanisms of B supplementation on CS development and CW remodeling in rice. Compared with Cd treatment alone, the Cd uptake per root area and the Cd translocation factor were reduced by 31.8% and 17.2%, respectively, under CdB treatment. Anatomical observations showed that B enhanced suberin lamellae and lignin deposition, resulting in wider and more developed CSs. Multi-omics analyses revealed that B supplementation activated the phenylpropanoid and suberin biosynthetic pathways, jointly promoting CS formation. B also improved root growth by stimulating the synthesis of growth-promoting phytohormones such as auxin, trans-zeatin, gibberellin, and brassinosteroid, while suppressing abscisic acid accumulation. Furthermore, B redirected glucose-1-phosphate flux toward CW biosynthesis and remodeling by inhibiting starch synthase activity and enhancing the activity of cellulose-degrading enzymes. These findings revealed the molecular and metabolic basis of B-mediated restriction of Cd uptake and translocation in rice, providing a strong theoretical framework for using B to mitigate Cd contamination in rice cultivation.
{"title":"Boron Fortifies a Dual Barrier in Rice Roots: How Casparian Strip Reinforcement and Cell Wall Remodeling Restrict Cadmium Entry","authors":"Zhihong Guo, Min Nie, Ting Li, Changfeng Ding, Gaoxiang Huang, Zhengfu Yue, Yurong Wang, Taolin Zhang, Rong Huang, Xingxiang Wang","doi":"10.1016/j.jhazmat.2026.141714","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.141714","url":null,"abstract":"The Casparian strip (CS) barrier and cell wall (CW) immobilization are key defense mechanisms that limit cadmium (Cd) uptake and translocation in plant roots. However, how boron (B) influences CS formation and CW remodeling in rice roots remains poorly understood. In this study, transcriptomic, metabolomic, and anatomical analyses were combined to elucidate, for the first time, the effects and underlying mechanisms of B supplementation on CS development and CW remodeling in rice. Compared with Cd treatment alone, the Cd uptake per root area and the Cd translocation factor were reduced by 31.8% and 17.2%, respectively, under CdB treatment. Anatomical observations showed that B enhanced suberin lamellae and lignin deposition, resulting in wider and more developed CSs. Multi-omics analyses revealed that B supplementation activated the phenylpropanoid and suberin biosynthetic pathways, jointly promoting CS formation. B also improved root growth by stimulating the synthesis of growth-promoting phytohormones such as auxin, trans-zeatin, gibberellin, and brassinosteroid, while suppressing abscisic acid accumulation. Furthermore, B redirected glucose-1-phosphate flux toward CW biosynthesis and remodeling by inhibiting starch synthase activity and enhancing the activity of cellulose-degrading enzymes. These findings revealed the molecular and metabolic basis of B-mediated restriction of Cd uptake and translocation in rice, providing a strong theoretical framework for using B to mitigate Cd contamination in rice cultivation.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"80 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147440287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1016/j.jhazmat.2026.141774
June Wee, Yun-Sik Lee, Yongeun Kim, Sun Hee Hong, Jinsol Hong, Kijong Cho
{"title":"Indirect ecological impacts of herbicides on soil collembolan communities through vegetation shifts","authors":"June Wee, Yun-Sik Lee, Yongeun Kim, Sun Hee Hong, Jinsol Hong, Kijong Cho","doi":"10.1016/j.jhazmat.2026.141774","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.141774","url":null,"abstract":"","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"16 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trace element contamination in sediments and edible gastropods from northwestern Morocco: Outdated consumption data conceal real health risks","authors":"Zakaria EL-AZZOUZI, Abdellatif CHAOUTI, Brahim SABOUR, Abdallah DAHBI","doi":"10.1016/j.jhazmat.2026.141772","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.141772","url":null,"abstract":"","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"63 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1016/j.jhazmat.2026.141766
Han Zhao, Junkai Xie, Shichen Wu, Xihui Zhao, Serena Yu, Jennifer L Freeman, Jean-Christophe Rochet, Chongli Yuan
Per- and polyfluoroalkyl substances (PFAS) are widely used in daily consumer and industrial products, and human exposure to PFAS has been associated with various neuronal disorders, including Alzheimer’s disease (AD), although the underlying mechanisms remain poorly understood. In this study, we investigated the neurotoxic effects of PFOA, a legacy PFAS, and GenX, its proposed “safer” alternative, using human induced pluripotent stem cell (hiPSC)-derived cortical neurons. To assess persistent neurotoxicity, neurons were assessed immediately after exposure and after a 7-day recovery. Neuronal resilience was evaluated using a secondary challenge assay targeting organelle-specific stressors. We identified distinct neurotoxic effects of PFOA and GenX, leading to increased risk of developing AD. PFOA exposure induced transient alteration in neuronal activity, neuron network morphology and synaptic density, but with persistent damage in mitochondria function, further corroborated with increased vulnerability towards mitochondria stress. GenX exposed neurons showed persistent alteration in neuronal network morphology and synaptic density, accompanied by persistent increase in vulnerability towards autolysosomal stress. Both PFOA and GenX triggered transient changes in AT8 and tau expression and conferred persistent vulnerability to tau-preformed fibrils (tau-PFF), implicating impaired proteostasis. Transcriptomic profiling further supported our findings. Collectively, our findings reveal divergent neurotoxic mechanisms of PFOA and GenX—mitochondrial damage versus autolysosomal stress—that converge on tau pathology, highlighting increased AD risk induced by PFAS exposure.
{"title":"Comparative Neurotoxic Effects of PFOA and GenX in hiPSC-Derived Cortical Neurons","authors":"Han Zhao, Junkai Xie, Shichen Wu, Xihui Zhao, Serena Yu, Jennifer L Freeman, Jean-Christophe Rochet, Chongli Yuan","doi":"10.1016/j.jhazmat.2026.141766","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.141766","url":null,"abstract":"Per- and polyfluoroalkyl substances (PFAS) are widely used in daily consumer and industrial products, and human exposure to PFAS has been associated with various neuronal disorders, including Alzheimer’s disease (AD), although the underlying mechanisms remain poorly understood. In this study, we investigated the neurotoxic effects of PFOA, a legacy PFAS, and GenX, its proposed “safer” alternative, using human induced pluripotent stem cell (hiPSC)-derived cortical neurons. To assess persistent neurotoxicity, neurons were assessed immediately after exposure and after a 7-day recovery. Neuronal resilience was evaluated using a secondary challenge assay targeting organelle-specific stressors. We identified distinct neurotoxic effects of PFOA and GenX, leading to increased risk of developing AD. PFOA exposure induced transient alteration in neuronal activity, neuron network morphology and synaptic density, but with persistent damage in mitochondria function, further corroborated with increased vulnerability towards mitochondria stress. GenX exposed neurons showed persistent alteration in neuronal network morphology and synaptic density, accompanied by persistent increase in vulnerability towards autolysosomal stress. Both PFOA and GenX triggered transient changes in AT8 and tau expression and conferred persistent vulnerability to tau-preformed fibrils (tau-PFF), implicating impaired proteostasis. Transcriptomic profiling further supported our findings. Collectively, our findings reveal divergent neurotoxic mechanisms of PFOA and GenX—mitochondrial damage versus autolysosomal stress—that converge on tau pathology, highlighting increased AD risk induced by PFAS exposure.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"9 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147440285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-13DOI: 10.1016/j.jhazmat.2026.141757
Martin Novak, Frantisek Buzek, Bohuslava Cejkova, Daniel Hladky, Radim Seibert, Iva Hůnová, Blanka Krejci, Zdenka Chromcova, Jakub Hruška, Marketa Stepanova, Ivana Jackova, Jerzy Cabala, Lenka Buresova, Arnost Komarek, Frantisek Veselovsky, Jan Curik, Miroslav Tesar, Eva Prechova, Tereza Grabmüllerova, Petra Janotova
{"title":"Source apportionment of reactive nitrogen in fog vs. rain using isotope ratios and Bayesian modeling (Ore and Eagle Mts., Central Europe)","authors":"Martin Novak, Frantisek Buzek, Bohuslava Cejkova, Daniel Hladky, Radim Seibert, Iva Hůnová, Blanka Krejci, Zdenka Chromcova, Jakub Hruška, Marketa Stepanova, Ivana Jackova, Jerzy Cabala, Lenka Buresova, Arnost Komarek, Frantisek Veselovsky, Jan Curik, Miroslav Tesar, Eva Prechova, Tereza Grabmüllerova, Petra Janotova","doi":"10.1016/j.jhazmat.2026.141757","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.141757","url":null,"abstract":"","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"270 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Synthetic/recycled rubber materials are widely used in playgrounds, artificial turf infill, and synthetic tracks, but they may contain harmful substances, such as metal(oid)s, posing health risks through ingestion and inhalation. The use of such materials and artificial turf has raised increasing concern, and several studies have begun to investigate the pollutants potentially released into simulated fluids (in-vitro bioaccessibility) to provide a more realistic assessment of the associated health risks. In this context, the present study reports, the estimation of the oral and inhalation bioavailability of metal(oid)s (bioaccessible fraction that can potentially be absorbed into the bloodstream and pose a major health risk) in synthetic/recycled rubber materials and artificial turf, from public facilities and brand-new samples. To this end, an in-vitro oral and inhalation bioavailability approach was applied using synthetic human fluids and dialysis membrane filled with simulated human plasma to mimic absorption, with subsequent metal(oid)s quantification. Higher inhalation bioavailability ratios (1.0 – 37.4% for Mo and Rb, respectively) were observed compared to oral ones (0.35 – 22.7% for Fe and Sr, respectively). Regarding the rubber composition, samples made of ethylene propylene diene monomer showed higher metal(oid)s bioavailability ratios than those made of styrene-butadiene-styrene, suggesting distinct metal(oid)s-polymer interactions influencing their release. Non-carcinogenic and carcinogenic hazard indexes via ingestion and inhalation were assessed using metal(oid) oral and inhalation bioavailable concentrations based on the California Office of Environmental Health Hazard Assessment exposure model. The results suggested no significant carcinogenic or non-carcinogenic risks for several scenarios, including children, adults, coaches, and bystanders from both exposition routes.
{"title":"Estimation of Metal(oid)s Oral and Inhalation Bioavailability in Synthetic and Recycled Rubber Materials and Artificial Turf Using a Dialyzability-Based In-Vitro Approach","authors":"Joel Sánchez-Piñero, Aaron Longueira-Ordóñez, Isabel Turnes-Carou, Soledad Muniategui-Lorenzo, Purificación López-Mahía, Jorge Moreda-Piñeiro","doi":"10.1016/j.jhazmat.2026.141755","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2026.141755","url":null,"abstract":"Synthetic/recycled rubber materials are widely used in playgrounds, artificial turf infill, and synthetic tracks, but they may contain harmful substances, such as metal(oid)s, posing health risks through ingestion and inhalation. The use of such materials and artificial turf has raised increasing concern, and several studies have begun to investigate the pollutants potentially released into simulated fluids (<em>in-vitro</em> bioaccessibility) to provide a more realistic assessment of the associated health risks. In this context, the present study reports, the estimation of the oral and inhalation bioavailability of metal(oid)s (bioaccessible fraction that can potentially be absorbed into the bloodstream and pose a major health risk) in synthetic/recycled rubber materials and artificial turf, from public facilities and brand-new samples. To this end, an <em>in-vitro</em> oral and inhalation bioavailability approach was applied using synthetic human fluids and dialysis membrane filled with simulated human plasma to mimic absorption, with subsequent metal(oid)s quantification. Higher inhalation bioavailability ratios (1.0 – 37.4% for Mo and Rb, respectively) were observed compared to oral ones (0.35 – 22.7% for Fe and Sr, respectively). Regarding the rubber composition, samples made of ethylene propylene diene monomer showed higher metal(oid)s bioavailability ratios than those made of styrene-butadiene-styrene, suggesting distinct metal(oid)s-polymer interactions influencing their release. Non-carcinogenic and carcinogenic hazard indexes via ingestion and inhalation were assessed using metal(oid) oral and inhalation bioavailable concentrations based on the California Office of Environmental Health Hazard Assessment exposure model. The results suggested no significant carcinogenic or non-carcinogenic risks for several scenarios, including children, adults, coaches, and bystanders from both exposition routes.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"26 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147440304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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