Rising glbal population and plastic consumption have caused a dramatic increase in plastic waste, leading to micro- and nanoplastic ingestion by aquatic organisms and subsequent bioaccumulation in their tissues. This transfer to higher trophic levels raises nanoplastic concentrations and bioavailability, potentially harming organisms' health and development. This poses a risk to human health via seafood. To address these issues, this study assesses the toxicological impacts of nanoplastics (NPs) on brine shrimp (Artemia franciscana) and their trophic transfer to zebrafish. The research unveiled a concentration-dependent bioaccumulation of NPs in zebrafish and Artemia franciscana (A. franciscana). Polystyrene nanoplastics (PS-NPs) exhibited higher accumulation in A. franciscana whereas PP-NPs showed greater accumulation in zebrafish gut. Histopathological analysis under PS-NPs exposure revealed significant tissue alterations, indicative of inflammatory responses and impaired mucosal barrier integrity. Gene expression analyses confirmed these findings, showing activation of the P38-MAPK pathway by PS-NPs, which correlated with increased inflammatory cytokines. Additionally, PE-NPs activated the JNK-MAPK pathway, while PP-NPs exposure triggered the NOD-like receptor signaling pathway. Moreover, the composition of gut microbiota shifted to a dysbiotic state, characterized by an increase in pathogenic bacteria in the PS-NPs and PP-NPs groups, elevating the risk of developing Inflammatory Bowel Disease (IBD). PS-NPs were regarded as the most toxic due to their lower stability and higher aggregation tendencies, followed by PP-NPs and PE-NPs. Taken together, the overall study highlighted the complex interactions between NPs, gut microbiota, and host health, emphasizing the importance of thoroughly assessing the ecological and physiological impacts of nanoplastic pollution.
{"title":"Trophic transfer induced gut inflammation, dysbiosis, and inflammatory pathways in zebrafish via Artemia franciscana: A differential analysis of nanoplastic toxicity","authors":"Marriya Sultan, Zi-Xin Cai, Li Bao, Jin-Jing Duan, Yi-Yun Liu, Guan Yang, De-Sheng Pei","doi":"10.1016/j.jhazmat.2024.136030","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136030","url":null,"abstract":"Rising glbal population and plastic consumption have caused a dramatic increase in plastic waste, leading to micro- and nanoplastic ingestion by aquatic organisms and subsequent bioaccumulation in their tissues. This transfer to higher trophic levels raises nanoplastic concentrations and bioavailability, potentially harming organisms' health and development. This poses a risk to human health via seafood. To address these issues, this study assesses the toxicological impacts of nanoplastics (NPs) on brine shrimp (<em>Artemia franciscana</em>) and their trophic transfer to zebrafish. The research unveiled a concentration-dependent bioaccumulation of NPs in zebrafish and <em>Artemia franciscana</em> (<em>A. franciscana</em>)<em>.</em> Polystyrene nanoplastics (PS-NPs) exhibited higher accumulation in <em>A. franciscana</em> whereas PP-NPs showed greater accumulation in zebrafish gut. Histopathological analysis under PS-NPs exposure revealed significant tissue alterations, indicative of inflammatory responses and impaired mucosal barrier integrity. Gene expression analyses confirmed these findings, showing activation of the P38-MAPK pathway by PS-NPs, which correlated with increased inflammatory cytokines. Additionally, PE-NPs activated the JNK-MAPK pathway, while PP-NPs exposure triggered the NOD-like receptor signaling pathway. Moreover, the composition of gut microbiota shifted to a dysbiotic state, characterized by an increase in pathogenic bacteria in the PS-NPs and PP-NPs groups, elevating the risk of developing Inflammatory Bowel Disease (IBD). PS-NPs were regarded as the most toxic due to their lower stability and higher aggregation tendencies, followed by PP-NPs and PE-NPs. Taken together, the overall study highlighted the complex interactions between NPs, gut microbiota, and host health, emphasizing the importance of thoroughly assessing the ecological and physiological impacts of nanoplastic pollution.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.jhazmat.2024.135999
Laura E. Dean, Hui Wang, Amanda J. Bullert, Hui Wang, Andrea Adamcakova-Dodd, Ashutosh K. Mangalam, Peter S. Thorne, James A. Ankrum, Aloysius J. Klingelhutz, Hans-Joachim Lehmler
Polychlorinated biphenyls (PCBs), such as PCB52, are hazardous environmental contaminants present in indoor and outdoor environments. Oral PCB exposure affects the colon microbiome; however, it is unknown if inhalation of PCBs alters the intestinal microbiome. We hypothesize that sub-acute inhalation of PCB52 affects microbial communities depending on the location in the (GI) gastrointestinal tract and the local profiles of PCB52 and its metabolites present in the GI tract following mucociliary clearance and biliary or intestinal excretion. Sprague-Dawley rats were exposed via nose-only inhalation 4 hours per day, 7 days per week, for 4 weeks to either filtered air or PCB52. After 28 days, differences in the microbiome and levels of PCB52 and its metabolites were characterized throughout the GI tract. PCB52 inhalation altered taxa abundances and predicted functions altered throughout the gut, with most alterations occurring in the large intestine. PCB52 and metabolite levels varied across the GI tract, resulting in differing PCB × microbiome networks. Thus, the presence of different PCB52 and its metabolites in different parts of the GI tract has varying effects on the composition and predicted function of microbial communities. Future studies need to investigate whether these changes lead to adverse outcomes.
{"title":"aInhalation of 2,2’,5,5’-Tetrachlorobiphenyl (PCB52) Causes Changes to the Gut Microbiome Throughout the Gastrointestinal Tract","authors":"Laura E. Dean, Hui Wang, Amanda J. Bullert, Hui Wang, Andrea Adamcakova-Dodd, Ashutosh K. Mangalam, Peter S. Thorne, James A. Ankrum, Aloysius J. Klingelhutz, Hans-Joachim Lehmler","doi":"10.1016/j.jhazmat.2024.135999","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.135999","url":null,"abstract":"Polychlorinated biphenyls (PCBs), such as PCB52, are hazardous environmental contaminants present in indoor and outdoor environments. Oral PCB exposure affects the colon microbiome; however, it is unknown if inhalation of PCBs alters the intestinal microbiome. We hypothesize that sub-acute inhalation of PCB52 affects microbial communities depending on the location in the (GI) gastrointestinal tract and the local profiles of PCB52 and its metabolites present in the GI tract following mucociliary clearance and biliary or intestinal excretion. Sprague-Dawley rats were exposed via nose-only inhalation 4<!-- --> <!-- -->hours per day, 7 days per week, for 4 weeks to either filtered air or PCB52. After 28 days, differences in the microbiome and levels of PCB52 and its metabolites were characterized throughout the GI tract. PCB52 inhalation altered taxa abundances and predicted functions altered throughout the gut, with most alterations occurring in the large intestine. PCB52 and metabolite levels varied across the GI tract, resulting in differing PCB × microbiome networks. Thus, the presence of different PCB52 and its metabolites in different parts of the GI tract has varying effects on the composition and predicted function of microbial communities. Future studies need to investigate whether these changes lead to adverse outcomes.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aims to optimize the time-dependent toxicity assessments for both single substances, particularly those causing hormesis, and mixtures that exhibit toxicological interactions. To achieve this, three time-dependent toxicity prediction methods were developed using geologic interpolation techniques: Inverse distance weighted (IDW), Kriging, and linear interpolation based on Delaunay triangulation (LDT). The toxicity of 7 single substances and 80 mixtures on Vibrio qinghaiensis sp.-Q67, along with 6 single substances and 19 mixtures on Microcystis aeruginosa, were assessed to evaluate the predictive accuracy of these methods. The coefficient of determination (R2), mean absolute error (MAE), and root-mean-square error (RMSE) were employed as performance metrics during cross-validation. The results showed that IDW underperformed LDT and Kriging in terms of both RMSE and MAE, indicating that LDT and Kriging had superior accuracy compared to IDW. Although LDT and Kriging demonstrated comparable predictive capabilities, LDT was identified as the more practical option for time-dependent toxicity prediction due to its simplicity and no requirement for parameter tuning. Consequently, LDT was presented as a new, efficient, and user-friendly tool for assessing the time-dependent toxicity of both individual chemicals and chemical mixtures. LDT will help to better assess the ecological risks of chemicals.
{"title":"Comparison of three spatial interpolation methods in predicting time-dependent toxicities of single substances and mixtures","authors":"Rui Qu, Yuanzhao Xiong, Ruiping Li, Jiwen Hu, Honglin Liu, Yingping Huang","doi":"10.1016/j.jhazmat.2024.136029","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136029","url":null,"abstract":"This study aims to optimize the time-dependent toxicity assessments for both single substances, particularly those causing hormesis, and mixtures that exhibit toxicological interactions. To achieve this, three time-dependent toxicity prediction methods were developed using geologic interpolation techniques: Inverse distance weighted (IDW), Kriging, and linear interpolation based on Delaunay triangulation (LDT). The toxicity of 7 single substances and 80 mixtures on <em>Vibrio qinghaiensis</em> sp.-Q67, along with 6 single substances and 19 mixtures on <em>Microcystis aeruginosa</em>, were assessed to evaluate the predictive accuracy of these methods. The coefficient of determination (R<sup>2</sup>), mean absolute error (MAE), and root-mean-square error (RMSE) were employed as performance metrics during cross-validation. The results showed that IDW underperformed LDT and Kriging in terms of both RMSE and MAE, indicating that LDT and Kriging had superior accuracy compared to IDW. Although LDT and Kriging demonstrated comparable predictive capabilities, LDT was identified as the more practical option for time-dependent toxicity prediction due to its simplicity and no requirement for parameter tuning. Consequently, LDT was presented as a new, efficient, and user-friendly tool for assessing the time-dependent toxicity of both individual chemicals and chemical mixtures. LDT will help to better assess the ecological risks of chemicals.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Virulence factor genes (VFGs) pose a potential threat to ecological security and animal health, and have attracted increasing attention in the livestock industry. As one of the primary livestock types, dairy cattle may be an important source of VFG transmission. However, the distribution, transmission, and evolution of VFGs in the gastrointestinal tract and surrounding environment of dairy cattle remain unclear. In the present study, a total of 263 samples were collected from cows, calves, colostrum, farm wastewater, and soil. Metagenomics was conducted to analyze changes in the microbiome and VFGs characteristics in these ecological niches. The VFGs of the cows showed distinct differences between the rumen and feces, and were influenced by the region. The dominant VFG hosts was regulated by their microbial structure. Colostrum administration of cows increased VFG abundance in their newborn calf feces sharply and Enterobacteriaceae became the primary host. While diet was the primary driving force for the temporal variation in calf VFGs. For samples of the surrounding environment, water and soil had higher VFG concentrations and were more structurally stable. Moreover, extensive interactions between the mobile genetic elements and VFGs and gene mobile analysis map based on metagenomic binning both displayed the potential horizontal transfer ability of VFGs in the cows and environment. Our study revealed the prevalence, diffusion, and regulatory factors of VFGs in dairy cattle production systems, providing novel insights into reducing livestock VFGs and limiting their spread.
{"title":"Metagenomics reveals the characteristics and potential spread of microbiomes and virulence factor genes in the dairy cattle production system","authors":"Yimin Zhuang, Shuai Liu, Jianxin Xiao, Tianyu Chen, Duo Gao, Yiming Xu, Wen Jiang, Jingjun Wang, Guobin Hou, Sumin Li, Xinjie Zhao, Yanting Huang, Shangru Li, Siyuan Zhang, Mengmeng Li, Wei Wang, Shengli Li, Zhijun Cao","doi":"10.1016/j.jhazmat.2024.136005","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136005","url":null,"abstract":"Virulence factor genes (VFGs) pose a potential threat to ecological security and animal health, and have attracted increasing attention in the livestock industry. As one of the primary livestock types, dairy cattle may be an important source of VFG transmission. However, the distribution, transmission, and evolution of VFGs in the gastrointestinal tract and surrounding environment of dairy cattle remain unclear. In the present study, a total of 263 samples were collected from cows, calves, colostrum, farm wastewater, and soil. Metagenomics was conducted to analyze changes in the microbiome and VFGs characteristics in these ecological niches. The VFGs of the cows showed distinct differences between the rumen and feces, and were influenced by the region. The dominant VFG hosts was regulated by their microbial structure. Colostrum administration of cows increased VFG abundance in their newborn calf feces sharply and <em>Enterobacteriaceae</em> became the primary host. While diet was the primary driving force for the temporal variation in calf VFGs. For samples of the surrounding environment, water and soil had higher VFG concentrations and were more structurally stable. Moreover, extensive interactions between the mobile genetic elements and VFGs and gene mobile analysis map based on metagenomic binning both displayed the potential horizontal transfer ability of VFGs in the cows and environment. Our study revealed the prevalence, diffusion, and regulatory factors of VFGs in dairy cattle production systems, providing novel insights into reducing livestock VFGs and limiting their spread.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.jhazmat.2024.136025
Lhiam Paton, Nick Marczinczik, Thomas Lindsay, Raquel Gonzalez De Vega, Etienne Skrzypek, Thebny Thaise Moro, Brigid A. McKenna, Casey Doolette, Enzo Lombi, David Clases, Jörg Feldmann
Many oil and gas developments will soon be decommissioned and, knowledge on the accumulation of mercury (Hg), throughout offshore infrastructure is limited. Any release of Hg could have a detrimental impact on marine ecosystems. To bridge this knowledge gap, a fractionation approach was taken on steel samples exposed to Hg0 and H2S, separating Hg compounds removed from the surface into polar, non-polar and insoluble fractions. Hg0 reacted on corroded surfaces to form several compounds, over 50% of which were removed by seawater. This suggests that pipelines on the seabed could release a dramatic amount of Hg into the sea if they are left in place. Furthermore, a Cu-Hg amalgam, was identified to be a dominant species, by a combination of XFM, XANES and LA-ICP-TOFMS. Seawater-soluble and amalgam-bound Hg were present regardless of co-exposure to H2S. When H2S was present Hg nanoparticles accounted for up to 1% of the total Hg on the steel. This investigation has shown that the Hg speciation on the surfaces of pipelines is complex and future decommissioning strategies should consider a range of Hg species beyond only Hg0 and metacinnabar (β-HgS), all of which could interact with biota and impact Hg biomagnification through the marine the food web.
{"title":"Investigating how H2S can alter the interactions between Hg0 and corroded steel surfaces to guide future decommissioning projects","authors":"Lhiam Paton, Nick Marczinczik, Thomas Lindsay, Raquel Gonzalez De Vega, Etienne Skrzypek, Thebny Thaise Moro, Brigid A. McKenna, Casey Doolette, Enzo Lombi, David Clases, Jörg Feldmann","doi":"10.1016/j.jhazmat.2024.136025","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136025","url":null,"abstract":"Many oil and gas developments will soon be decommissioned and, knowledge on the accumulation of mercury (Hg), throughout offshore infrastructure is limited. Any release of Hg could have a detrimental impact on marine ecosystems. To bridge this knowledge gap, a fractionation approach was taken on steel samples exposed to Hg<sup>0</sup> and H<sub>2</sub>S, separating Hg compounds removed from the surface into polar, non-polar and insoluble fractions. Hg<sup>0</sup> reacted on corroded surfaces to form several compounds, over 50% of which were removed by seawater. This suggests that pipelines on the seabed could release a dramatic amount of Hg into the sea if they are left in place. Furthermore, a Cu-Hg amalgam, was identified to be a dominant species, by a combination of XFM, XANES and LA-ICP-TOFMS. Seawater-soluble and amalgam-bound Hg were present regardless of co-exposure to H<sub>2</sub>S. When H<sub>2</sub>S was present Hg nanoparticles accounted for up to 1% of the total Hg on the steel. This investigation has shown that the Hg speciation on the surfaces of pipelines is complex and future decommissioning strategies should consider a range of Hg species beyond only Hg<sup>0</sup> and metacinnabar (β-HgS), all of which could interact with biota and impact Hg biomagnification through the marine the food web.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.jhazmat.2024.136021
Seonggan Jang, Changmin Kim, Heejun Suk, Minjune Yang
This study presents analytical solutions for describing contaminant storage and release from an aquitard with linear source depletion (LSD) boundary conditions. We investigated three scenarios for trichloroethylene (TCE) mass exchange before and after the LSD period in an aquifer bounded by an adjacent aquitard based on the LSD dynamics, a resistance coefficient, and the aquitard thickness. The developed analytical solutions showed good agreement with measured profiles and breakthrough curves from a previous study. In three scenarios, the factors delaying the onset of TCE release into the aquifer were a decrease in the resistance coefficient, an increase in LSD period and aquitard thickness. The changes in the duration, mass, and rate of TCE storage in the aquitard during LSD loading process affected the equilibrium of the aquifer-aquitard concentration gradient. After TCE loading, the period maintained above the maximum contaminant level was directly related to the three variables; the longest plume persistence occurred when TCE penetration distance at transition point from storage to release coincided with the aquitard thickness. Overall, the developed analytical solution aids in evaluating the risk of plume persistence, enhancing site management efficiency, and reducing remediation costs.
{"title":"Assessing the persistence of a contaminant plume generated by linear aquifer source depletion and back diffusion from an aquitard","authors":"Seonggan Jang, Changmin Kim, Heejun Suk, Minjune Yang","doi":"10.1016/j.jhazmat.2024.136021","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136021","url":null,"abstract":"This study presents analytical solutions for describing contaminant storage and release from an aquitard with linear source depletion (LSD) boundary conditions. We investigated three scenarios for trichloroethylene (TCE) mass exchange before and after the LSD period in an aquifer bounded by an adjacent aquitard based on the LSD dynamics, a resistance coefficient, and the aquitard thickness. The developed analytical solutions showed good agreement with measured profiles and breakthrough curves from a previous study. In three scenarios, the factors delaying the onset of TCE release into the aquifer were a decrease in the resistance coefficient, an increase in LSD period and aquitard thickness. The changes in the duration, mass, and rate of TCE storage in the aquitard during LSD loading process affected the equilibrium of the aquifer-aquitard concentration gradient. After TCE loading, the period maintained above the maximum contaminant level was directly related to the three variables; the longest plume persistence occurred when TCE penetration distance at transition point from storage to release coincided with the aquitard thickness. Overall, the developed analytical solution aids in evaluating the risk of plume persistence, enhancing site management efficiency, and reducing remediation costs.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-01DOI: 10.1016/j.jhazmat.2024.136028
Jian Xie, Jiale ji, Yun Sun, Yifan Ma, Di Wu, Zhijun Zhang
The widespread use of plastics has led to increased micro- and nanoplastics (MNPs) pollution, resulting in significant environmental challenges and concerns about potential harm to human health. This study investigated whether certain types of MNPs can accumulate in the human central nervous system (CNS) and trigger inflammatory responses, particularly after CNS infection. Our analysis of 28 cerebrospinal fluid (CSF) samples from 28 patients with or without CNS infection revealed that only polystyrene (PS), polyethylene (PE), polypropylene (PP), and polyvinyl chloride (PVC) were capable of selectively entering the human CNS. Concentrations of PP and PE were positively correlated with the CSF albumin index. The levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) were significantly increased in patients with CNS infections. However, concentrations of MNPs were not significantly associated with CSF levels of IL-6 or IL-8. Overall, these findings suggest that specific MNPs can penetrate the human CNS, especially after impairment of the blood-brain barrier. Notably, MNPs derived from commonly used plastics did not significantly induce or exacerbate inflammation in the human CNS.
{"title":"Blood-brain barrier damage accelerates the accumulation of micro- and nanoplastics in the human central nervous system","authors":"Jian Xie, Jiale ji, Yun Sun, Yifan Ma, Di Wu, Zhijun Zhang","doi":"10.1016/j.jhazmat.2024.136028","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136028","url":null,"abstract":"The widespread use of plastics has led to increased micro- and nanoplastics (MNPs) pollution, resulting in significant environmental challenges and concerns about potential harm to human health. This study investigated whether certain types of MNPs can accumulate in the human central nervous system (CNS) and trigger inflammatory responses, particularly after CNS infection. Our analysis of 28 cerebrospinal fluid (CSF) samples from 28 patients with or without CNS infection revealed that only polystyrene (PS), polyethylene (PE), polypropylene (PP), and polyvinyl chloride (PVC) were capable of selectively entering the human CNS. Concentrations of PP and PE were positively correlated with the CSF albumin index. The levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) were significantly increased in patients with CNS infections. However, concentrations of MNPs were not significantly associated with CSF levels of IL-6 or IL-8. Overall, these findings suggest that specific MNPs can penetrate the human CNS, especially after impairment of the blood-brain barrier. Notably, MNPs derived from commonly used plastics did not significantly induce or exacerbate inflammation in the human CNS.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Constructed wetlands (CWs) are an effective method for removing microplastics (MPs). Nevertheless, the understanding of the impact of various parameters on MPs removal within CWs remains incomplete. Through field investigations of large-scale CWs and the application of machine learning methods with an interpretable attribution technique (the Shapley Additive Explanation), we investigated the critical factors influencing MPs removal within CWs. The MPs abundance in the influent and the inlet of Z-CW (400.1±20.8 items/L and 699.6±50.6 items/kg) was significantly higher compared to that in M-CW (138.8±20.5 items/L and 166.5±36.8 items/kg), with no significant difference observed in the effluent. The primary characteristic of MPs is their fibrous and transparent appearance. The MPs removal range from 87.9–95.5%, influenced by the types and characteristics of MPs, physical and chemical parameters, biofilms, and different processes. Among these factors, dissolved organic carbon with high humic content, aromaticity, and carboxyl abundance may serve as a crucial factor in MPs removal. The results of this study highlight the significance of physical and chemical parameters for the MPs removal in CWs, providing the necessary theoretical data for the construction of future large-scale engineering applications.
{"title":"The crucial factor for microplastics removal in large-scale subsurface-flow constructed wetlands","authors":"Shiwen Zhang, Tianshuai Li, Huijun Xie, Maoyong Song, Shengxuan Huang, Zizhang Guo, Zhen Hu, Jian Zhang","doi":"10.1016/j.jhazmat.2024.136023","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136023","url":null,"abstract":"Constructed wetlands (CWs) are an effective method for removing microplastics (MPs). Nevertheless, the understanding of the impact of various parameters on MPs removal within CWs remains incomplete. Through field investigations of large-scale CWs and the application of machine learning methods with an interpretable attribution technique (the Shapley Additive Explanation), we investigated the critical factors influencing MPs removal within CWs. The MPs abundance in the influent and the inlet of Z-CW (400.1±20.8 items/L and 699.6±50.6 items/kg) was significantly higher compared to that in M-CW (138.8±20.5 items/L and 166.5±36.8 items/kg), with no significant difference observed in the effluent. The primary characteristic of MPs is their fibrous and transparent appearance. The MPs removal range from 87.9–95.5%, influenced by the types and characteristics of MPs, physical and chemical parameters, biofilms, and different processes. Among these factors, dissolved organic carbon with high humic content, aromaticity, and carboxyl abundance may serve as a crucial factor in MPs removal. The results of this study highlight the significance of physical and chemical parameters for the MPs removal in CWs, providing the necessary theoretical data for the construction of future large-scale engineering applications.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The effect of clay layer compression on the enrichment of groundwater fluoride remains unknown. Quaternary groundwater with high fluoride levels at the Cangzhou Plain, which has a long history of land subsidence caused by clay layer compression, poses a potential health risk. The spatial distribution and enrichment mechanisms of groundwater fluoride are identified by sample collection, hydrochemical analysis, and geochemical inverse modeling. The results revealed that fluoride concentrations in 82% of the 122 groundwater samples above the limit in drinking water as 1.0 mg/L in China. Fluoride in shallow groundwater (depth 20 m, ~average = 2.08 mg/L) was mainly originated from fluorite dissolution and influenced by groundwater , pH, and cation exchange levels. Below ~200 m, the main source of groundwater fluoride (~average = 3.12 mg/L) was the compression−release of clay pore water with high F− concentration, which was generated by complex water-rock interaction. Based on hydrochemical inverse simulation and end-member mixing models, the pore water released from clayey sediments supplied 53%−56% of deep groundwater (>200 m) and contributed 2.07−2.87 mg/L to F− concentration. The findings of this study provide a theoretical basis for future research on prevention of high fluoride groundwater induced by clayey sediment compression.
{"title":"Effect of clayey sediment compression on fluoride enrichment in the Quaternary groundwater system of Cangzhou Plain, China","authors":"Rui Liu, Haipeng Guo, Juan Chen, Haigang Wang, Xisheng Zang, Guijie Wang, Yunlong Wang, Juyan Zhu","doi":"10.1016/j.jhazmat.2024.136022","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136022","url":null,"abstract":"The effect of clay layer compression on the enrichment of groundwater fluoride remains unknown. Quaternary groundwater with high fluoride levels at the Cangzhou Plain, which has a long history of land subsidence caused by clay layer compression, poses a potential health risk. The spatial distribution and enrichment mechanisms of groundwater fluoride are identified by sample collection, hydrochemical analysis, and geochemical inverse modeling. The results revealed that fluoride concentrations in 82% of the 122 groundwater samples above the limit in drinking water as 1.0<!-- --> <!-- -->mg/L in China. Fluoride in shallow groundwater (depth <span><span><math><mo is=\"true\"><</mo><mspace is=\"true\" width=\"1em\"></mspace></math></span><script type=\"math/mml\"><math><mo is=\"true\"><</mo><mspace width=\"1em\" is=\"true\"></mspace></math></script></span>20<!-- --> <!-- --> m, ~average = 2.08<!-- --> <!-- -->mg/L) was mainly originated from fluorite dissolution and influenced by groundwater <span><span><math><mtext is=\"true\">HC</mtext><msubsup is=\"true\"><mrow is=\"true\"><mtext is=\"true\">O</mtext></mrow><mrow is=\"true\"><mn is=\"true\">3</mn></mrow><mrow is=\"true\"><mo is=\"true\">−</mo></mrow></msubsup></math></span><script type=\"math/mml\"><math><mtext is=\"true\">HC</mtext><msubsup is=\"true\"><mrow is=\"true\"><mtext is=\"true\">O</mtext></mrow><mrow is=\"true\"><mn is=\"true\">3</mn></mrow><mrow is=\"true\"><mo is=\"true\">−</mo></mrow></msubsup></math></script></span>, pH, and cation exchange levels. Below ~200<!-- --> <!-- -->m, the main source of groundwater fluoride (~average = 3.12<!-- --> <!-- -->mg/L) was the compression−release of clay pore water with high F<sup>−</sup> concentration, which was generated by complex water-rock interaction. Based on hydrochemical inverse simulation and end-member mixing models, the pore water released from clayey sediments supplied 53%−56% of deep groundwater (>200<!-- --> <!-- -->m) and contributed 2.07−2.87<!-- --> <!-- -->mg/L to F<sup>−</sup> concentration. The findings of this study provide a theoretical basis for future research on prevention of high fluoride groundwater induced by clayey sediment compression.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Three-dimensional (3D) distributions of multiple soil pollutants in industrial site are crucial for risk assessment and remediation. Yet, their 3D prediction accuracies are often low because of the strong variability of pollutants and availability of 3D covariate data. This study proposed a patch-based multi-task convolution neural network (MT-CNN) model for simultaneously predicting the 3D distributions of Zn, Pb, Ni, and Cu at an industrial site. By integrating neighborhood patches from multisource covariates, the MT-CNN model captured both horizontal and vertical pollution information, and outperformed the widely-used methods such as random forest (RF), ordinary Kriging (OK), and inverse distance weighting (IDW) for all the 4 heavy metals, with R2 values of 0.58, 0.56, 0.29 and 0.23 for Zn, Pb, Ni and Cu, respectively. Besides, the MT-CNN model achieved more stable predictions with reasonable accuracy, in comparison with the single-task CNN model. These results highlighted the potential of the proposed MT-CNN in simultaneously mapping the 3D distributions of multiple pollutants, while balancing the model training, maintaining and accuracy for low-cost rapid assessment of soil pollution at industrial sites.
{"title":"Simultaneously mapping the 3D distributions of multiple heavy metals in an industrial site using deep learning and multisource auxiliary data","authors":"Yuxuan Peng, Yongcun Zhao, Jian Chen, Enze Xie, Guojing Yan, Tingrun Zou, Xianghua Xu","doi":"10.1016/j.jhazmat.2024.136000","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2024.136000","url":null,"abstract":"Three-dimensional (3D) distributions of multiple soil pollutants in industrial site are crucial for risk assessment and remediation. Yet, their 3D prediction accuracies are often low because of the strong variability of pollutants and availability of 3D covariate data. This study proposed a patch-based multi-task convolution neural network (MT-CNN) model for simultaneously predicting the 3D distributions of Zn, Pb, Ni, and Cu at an industrial site. By integrating neighborhood patches from multisource covariates, the MT-CNN model captured both horizontal and vertical pollution information, and outperformed the widely-used methods such as random forest (RF), ordinary Kriging (OK), and inverse distance weighting (IDW) for all the 4 heavy metals, with R<sup>2</sup> values of 0.58, 0.56, 0.29 and 0.23 for Zn, Pb, Ni and Cu, respectively. Besides, the MT-CNN model achieved more stable predictions with reasonable accuracy, in comparison with the single-task CNN model. These results highlighted the potential of the proposed MT-CNN in simultaneously mapping the 3D distributions of multiple pollutants, while balancing the model training, maintaining and accuracy for low-cost rapid assessment of soil pollution at industrial sites.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":null,"pages":null},"PeriodicalIF":13.6,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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