Xuan Wei has China’s highest female lung cancer mortality, attributed to household coal smoke exposure. While coal-derived polycyclic aromatic hydrocarbons (PAHs) were previously blamed, persistently rising lung cancer rates despite PAH reductions implicate other carcinogens. Here, we aim to investigate iron-rich minerals in Late Permian coal as potential overlooked drivers. Coal was sampled from Laibin, epicentre of Xuan Wei lung cancer epidemic. Mineral phases in low temperature ash (LTA) were characterized by X-ray diffraction (XRD) along with selected area electron diffraction (SAED) and high-resolution transmission electron microscopy (TEM). Mineral morphology and elemental composition were examined by Scanning Electron Microscope (SEM) and TEM equipped with energy-dispersive X-ray spectrometer (EDS). Lung tissues from 10 patients (5 female, 5 male) were examined for mineral deposition by SEM and TEM. We identified acicular iron-rich interstratified berthierine-chamosite minerals coating quartz/calcite in coal. Berthierine shares the serpentine group classification with chrysotile (i.e., white asbestos, a known human carcinogen). We observed abundant berthierine-chamosite needles in cancerous and para-cancerous lung tissues, with iron leaching from the berthierine-chamosite into acidic digestive vacuoles and accumulating in holo-ferritin and hemosiderin aggregates within autolysosomes. Given its much higher iron content than chrysotile, this needle-like berthierine-chamosite in Late Permian coal could be more bioactive and toxic, potentially driving the lung cancer epidemic in Xuan Wei, China. Our findings call for closer collaboration between mineralogists and health scientists for future research to gain deeper mechanistic insights and formulate intervention strategies.
{"title":"Acicular berthierine-chamosite in coal and lung cancer tissues of Xuan Wei, China","authors":"Zheshen Han, Hongli Lin, Renyue Ji, Lijun Liu, Pei Zhang, Chao Jiang, Shijie Zhu, Jialin Xu, Zhenghong Yang, Yunchao Huang, Toshihiro Kogure, Fang Guo, Linwei Tian","doi":"10.1016/j.jhazmat.2025.140844","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.140844","url":null,"abstract":"Xuan Wei has China’s highest female lung cancer mortality, attributed to household coal smoke exposure. While coal-derived polycyclic aromatic hydrocarbons (PAHs) were previously blamed, persistently rising lung cancer rates despite PAH reductions implicate other carcinogens. Here, we aim to investigate iron-rich minerals in Late Permian coal as potential overlooked drivers. Coal was sampled from Laibin, epicentre of Xuan Wei lung cancer epidemic. Mineral phases in low temperature ash (LTA) were characterized by X-ray diffraction (XRD) along with selected area electron diffraction (SAED) and high-resolution transmission electron microscopy (TEM). Mineral morphology and elemental composition were examined by Scanning Electron Microscope (SEM) and TEM equipped with energy-dispersive X-ray spectrometer (EDS). Lung tissues from 10 patients (5 female, 5 male) were examined for mineral deposition by SEM and TEM. We identified acicular iron-rich interstratified berthierine-chamosite minerals coating quartz/calcite in coal. Berthierine shares the serpentine group classification with chrysotile (i.e., white asbestos, a known human carcinogen). We observed abundant berthierine-chamosite needles in cancerous and para-cancerous lung tissues, with iron leaching from the berthierine-chamosite into acidic digestive vacuoles and accumulating in holo-ferritin and hemosiderin aggregates within autolysosomes. Given its much higher iron content than chrysotile, this needle-like berthierine-chamosite in Late Permian coal could be more bioactive and toxic, potentially driving the lung cancer epidemic in Xuan Wei, China. Our findings call for closer collaboration between mineralogists and health scientists for future research to gain deeper mechanistic insights and formulate intervention strategies.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"36 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The discharge of organophosphate esters (OPEs) in wastewater increasingly threatens aquatic ecosystems. Although biological nitrogen removal (BNR) system shows potential OPEs removal and the performance might be influenced by phosphorus sources, the underlying mechanisms remained poorly understood. This study investigated the synchronous OPEs and nitrogen removal under varying phosphorus source conditions, revealing the microbial insights and ecological collaboration that facilitated OPEs degradation in BNR systems. Results demonstrated that the acclimated BNR systems achieved almost complete degradation of 10mg/L tri-n-butyl phosphate (TnBP) and tris(2-chloroethyl) phosphate (TCEP). OPEs degradation pathways mainly involved hydrolysis, hydroxylation, and dehydrogenation, while phosphorus limitation could enhance the enzymatic activities of phosphotriesterase (PTE) and alkaline phosphatase (ALP). 16S rRNA sequencing and metagenomic analysis revealed that Rhodococcus, Nitrospira, and Phaeodactylibacter were the enriched OPEs degraders, which harbored pivotal functional genes including php, phoD, glpQ, and cpdA. Moreover, molecular ecological networks analysis highlighted synergistic interactions among nitrifying bacteria, denitrifying bacteria, and OPEs degrader, suggesting the collaboration among consortia facilitated complete OPEs degradation. The microbial OPEs degrading functions and ecological interactions in BNR systems were further stimulated by phosphorus-limited condition. This study provides novel insights into the microbial mechanisms of OPEs degradation and offers a promising strategy for upgrading wastewater treatment plants to cope with emerging contaminants.
{"title":"Unveiling the simultaneous organophosphate esters degradation mechanisms in biological wastewater nitrogen removal systems under varying phosphorus source conditions: microbial insights and ecological interactions","authors":"Ziyuan Lin, Ziyu Yan, Weihao Kong, Yingwei Zhou, Yili Xu, Jiayi Xie, Weikang Gu, Benzhou Gong, Yancheng Li, Chaolan Zhang","doi":"10.1016/j.jhazmat.2025.140835","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.140835","url":null,"abstract":"The discharge of organophosphate esters (OPEs) in wastewater increasingly threatens aquatic ecosystems. Although biological nitrogen removal (BNR) system shows potential OPEs removal and the performance might be influenced by phosphorus sources, the underlying mechanisms remained poorly understood. This study investigated the synchronous OPEs and nitrogen removal under varying phosphorus source conditions, revealing the microbial insights and ecological collaboration that facilitated OPEs degradation in BNR systems. Results demonstrated that the acclimated BNR systems achieved almost complete degradation of 10<ce:hsp sp=\"0.25\"></ce:hsp>mg/L tri-n-butyl phosphate (TnBP) and tris(2-chloroethyl) phosphate (TCEP). OPEs degradation pathways mainly involved hydrolysis, hydroxylation, and dehydrogenation, while phosphorus limitation could enhance the enzymatic activities of phosphotriesterase (PTE) and alkaline phosphatase (ALP). 16S rRNA sequencing and metagenomic analysis revealed that <ce:italic>Rhodococcus</ce:italic>, <ce:italic>Nitrospira</ce:italic>, and <ce:italic>Phaeodactylibacter</ce:italic> were the enriched OPEs degraders, which harbored pivotal functional genes including <ce:italic>php</ce:italic>, <ce:italic>phoD</ce:italic>, <ce:italic>glpQ</ce:italic>, and <ce:italic>cpdA</ce:italic>. Moreover, molecular ecological networks analysis highlighted synergistic interactions among nitrifying bacteria, denitrifying bacteria, and OPEs degrader, suggesting the collaboration among consortia facilitated complete OPEs degradation. The microbial OPEs degrading functions and ecological interactions in BNR systems were further stimulated by phosphorus-limited condition. This study provides novel insights into the microbial mechanisms of OPEs degradation and offers a promising strategy for upgrading wastewater treatment plants to cope with emerging contaminants.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"16 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.jhazmat.2025.140825
Xiaohong Jia, Biao Song, Sirong Wang, Yaoxin Wang, Yuxin Bi, Yi Zheng, Kaiwen Zuo, Jinying Huang, Hong Sun, Gongbo Chen, Jie Ren, Yuewei Liu
Global ozone (O3) levels have increased by 30–70% over the past century, raising growing concerns about their impacts on human health under climate change. However, previous reviews have been regionally limited and lacked standardized exposure metrics or cause-specific analyses. To address these gaps, we systematically reviewed and quantitatively synthesized estimates from existing studies to evaluate associations of short-term O3 exposure with total and cause-specific mortality. We identified 178 eligible time-series and case-crossover studies published up to August 2025, including 760 effect estimates across diverse regions. Exposure data were standardized to daily maximum 8-hour averages, and relative risks (RRs) corresponding to a 10μg/m3 increase were pooled. With high certainty of evidence, short-term O3 exposure was positively associated with total mortality (RR: 1.0033; 95% CI: 1.0031–1.0036), cardiovascular mortality (RR: 1.0046; 95% CI: 1.0042–1.0050), and respiratory mortality (RR: 1.0047; 95% CI: 1.0040–1.0053). Heterogeneity was acceptable, and results were robust across sensitivity analyses. Potential nonlinear exposure–response relationships were identified, with thresholds ranging from 42.1 to 100µg/m3. The estimated population attributable fractions of short-term O3 exposure were 0.182%, 0.252%, and 0.258% for total, cardiovascular, and respiratory mortality, respectively. Risk of bias was generally low to moderate. These findings highlight a measurable global health burden attributable to short-term O3 exposure and provide the most up-to-date evidence supporting stricter O3 air quality standards, particularly in low- and middle-income countries.
{"title":"Association of short-term exposure to ozone with total and cause-specific mortality: A systematic review and meta-analysis","authors":"Xiaohong Jia, Biao Song, Sirong Wang, Yaoxin Wang, Yuxin Bi, Yi Zheng, Kaiwen Zuo, Jinying Huang, Hong Sun, Gongbo Chen, Jie Ren, Yuewei Liu","doi":"10.1016/j.jhazmat.2025.140825","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.140825","url":null,"abstract":"Global ozone (O<ce:inf loc=\"post\">3</ce:inf>) levels have increased by 30–70% over the past century, raising growing concerns about their impacts on human health under climate change. However, previous reviews have been regionally limited and lacked standardized exposure metrics or cause-specific analyses. To address these gaps, we systematically reviewed and quantitatively synthesized estimates from existing studies to evaluate associations of short-term O<ce:inf loc=\"post\">3</ce:inf> exposure with total and cause-specific mortality. We identified 178 eligible time-series and case-crossover studies published up to August 2025, including 760 effect estimates across diverse regions. Exposure data were standardized to daily maximum 8-hour averages, and relative risks (RRs) corresponding to a 10<ce:hsp sp=\"0.25\"></ce:hsp>μg/m<ce:sup loc=\"post\">3</ce:sup> increase were pooled. With high certainty of evidence, short-term O<ce:inf loc=\"post\">3</ce:inf> exposure was positively associated with total mortality (RR: 1.0033; 95% CI: 1.0031–1.0036), cardiovascular mortality (RR: 1.0046; 95% CI: 1.0042–1.0050), and respiratory mortality (RR: 1.0047; 95% CI: 1.0040–1.0053). Heterogeneity was acceptable, and results were robust across sensitivity analyses. Potential nonlinear exposure–response relationships were identified, with thresholds ranging from 42.1 to 100<ce:hsp sp=\"0.25\"></ce:hsp>µg/m<ce:sup loc=\"post\">3</ce:sup>. The estimated population attributable fractions of short-term O<ce:inf loc=\"post\">3</ce:inf> exposure were 0.182%, 0.252%, and 0.258% for total, cardiovascular, and respiratory mortality, respectively. Risk of bias was generally low to moderate. These findings highlight a measurable global health burden attributable to short-term O<ce:inf loc=\"post\">3</ce:inf> exposure and provide the most up-to-date evidence supporting stricter O<ce:inf loc=\"post\">3</ce:inf> air quality standards, particularly in low- and middle-income countries.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"48 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.jhazmat.2025.140775
Si-Yi Shi, Yao Lu, Yi-Ran Wan, Chang-Jie Yuan, Wei Hu, Min Liu, Ying Chen, Ye Du
Ferrate (Fe(VI)) is a highly efficient oxidant with great potential for advanced wastewater treatment. In this study, a Fe(VI)/silica gel (SiO2) process was developed to enhance the detoxification performance of Fe(VI). While SiO2 alone showed no cytotoxicity removal, the addition of 0.1 g/L SiO2 to Fe(VI) reduced the cytotoxicity of wastewater from 8.3 to 8.5 mg/L to 4.8–5.6 mg/L, corresponding to a 47.3 % removal efficiency for the secondary effluent. Compared to Fe(VI) alone, the activated process achieved improved reductions in UV254 absorbance and fluorescent components, including tryptophan-like, humic-like, and fulvic-like substances. High-resolution mass spectrometry (HRMS) revealed that the number of CHON-type dissolved organic matter (DOM) species removed increased from 709 (Fe(VI) alone) to 982, with the majority being highly toxic and aromatic compounds. Moreover, many micropollutants which exhibited poor reactivity and low degradation efficiency when treated with only Fe(VI), were effectively removed in the activated process. The Fe(VI)/SiO2 process achieved removal efficiencies over 30 % higher than the Fe(VI) process for 27 compounds, including highly toxic CHON-type micropollutants such as 1,2,3,4-tetrahydropyridin-4-one and 4-aminoantipyrine. The enhanced removal performance is because of the enhanced •OH formation, rather than Fe(IV)/Fe(V) formation or flocculation. Mechanistic analysis revealed that hydroxyl and silanol groups on the silica surface act as activation sites for Fe(VI), facilitating •OH generation and accelerating the degradation of toxic pollutants. These findings highlight the potential of the Fe(VI)/SiO2 process as an efficient solution for advanced detoxification in wastewater treatment.
{"title":"Enhanced removal of cytotoxicity from wastewater by silica gel-activated ferrate (VI)","authors":"Si-Yi Shi, Yao Lu, Yi-Ran Wan, Chang-Jie Yuan, Wei Hu, Min Liu, Ying Chen, Ye Du","doi":"10.1016/j.jhazmat.2025.140775","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.140775","url":null,"abstract":"Ferrate (Fe(VI)) is a highly efficient oxidant with great potential for advanced wastewater treatment. In this study, a Fe(VI)/silica gel (SiO<ce:inf loc=\"post\">2</ce:inf>) process was developed to enhance the detoxification performance of Fe(VI). While SiO<ce:inf loc=\"post\">2</ce:inf> alone showed no cytotoxicity removal, the addition of 0.1 g/L SiO<ce:inf loc=\"post\">2</ce:inf> to Fe(VI) reduced the cytotoxicity of wastewater from 8.3 to 8.5 mg/L to 4.8–5.6 mg/L, corresponding to a 47.3 % removal efficiency for the secondary effluent. Compared to Fe(VI) alone, the activated process achieved improved reductions in UV<ce:inf loc=\"post\">254</ce:inf> absorbance and fluorescent components, including tryptophan-like, humic-like, and fulvic-like substances. High-resolution mass spectrometry (HRMS) revealed that the number of CHON-type dissolved organic matter (DOM) species removed increased from 709 (Fe(VI) alone) to 982, with the majority being highly toxic and aromatic compounds. Moreover, many micropollutants which exhibited poor reactivity and low degradation efficiency when treated with only Fe(VI), were effectively removed in the activated process. The Fe(VI)/SiO<ce:inf loc=\"post\">2</ce:inf> process achieved removal efficiencies over 30 % higher than the Fe(VI) process for 27 compounds, including highly toxic CHON-type micropollutants such as 1,2,3,4-tetrahydropyridin-4-one and 4-aminoantipyrine. The enhanced removal performance is because of the enhanced •OH formation, rather than Fe(IV)/Fe(V) formation or flocculation. Mechanistic analysis revealed that hydroxyl and silanol groups on the silica surface act as activation sites for Fe(VI), facilitating •OH generation and accelerating the degradation of toxic pollutants. These findings highlight the potential of the Fe(VI)/SiO<ce:inf loc=\"post\">2</ce:inf> process as an efficient solution for advanced detoxification in wastewater treatment.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"157 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.jhazmat.2025.140839
Lila Bazina, Glen M. Deloid, Leonardo Calderon, Luke Fritzky, Nachiket Vaze, Irini Tsiodra, Nikolas Mihalopoulos, Theodoros Pyrsopoulos, Philip Demokritou
Inhalation exposure to micro-nanoplastics (MNPs) generated by plastic waste incineration is an emerging public health concern. This study assessed the impact of nanoparticles emitted during the incineration of high-density polyethylene (HDPE-I) on THP-1 lung macrophages. HDPE-I nanoparticles (<0.1µm) were generated using an Integrated Exposure Generation System and collected with a Compact Cascade Impactor. Elemental and chemical analysis of HDPE-I revealed large amounts of sulfur, multiple metals (aluminum, magnesium, calcium, potassium, and iron), and high concentrations of toxic high molecular weight polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs), including the highly carcinogenic PAH benzo[c]fluorene. The overall carcinogenicity potential of HDPE-I PAHs, in benzo[a]pyrene equivalents (BaPEq), was 798.02ng/m3, orders of magnitude higher than that of other ambient anthropogenic nanoparticles. Exposure of THP-1 macrophages to HDPE-I increased cytotoxicity and reduced mitochondrial membrane potential, while also impairing phagocytosis by ~79%. RNA-seq analysis revealed activation of xenobiotic metabolism and stress-response pathways, particularly through AhR signaling, and altered expression of immune-related genes. These findings suggest that inhalation of MNPs emitted from plastic incineration may compromise alveolar macrophage function, increasing susceptibility to environmental particles and respiratory pathogens. Stricter waste management practices and regulatory policies are required to mitigate plastic burning emissions.
{"title":"Impact of Nanoplastics Emitted From Incineration of Polyethylene Plastic on THP-1 Macrophage Viability and Immune Function","authors":"Lila Bazina, Glen M. Deloid, Leonardo Calderon, Luke Fritzky, Nachiket Vaze, Irini Tsiodra, Nikolas Mihalopoulos, Theodoros Pyrsopoulos, Philip Demokritou","doi":"10.1016/j.jhazmat.2025.140839","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.140839","url":null,"abstract":"Inhalation exposure to micro-nanoplastics (MNPs) generated by plastic waste incineration is an emerging public health concern. This study assessed the impact of nanoparticles emitted during the incineration of high-density polyethylene (HDPE-I) on THP-1 lung macrophages. HDPE-I nanoparticles (<0.1<ce:hsp sp=\"0.25\"></ce:hsp>µm) were generated using an Integrated Exposure Generation System and collected with a Compact Cascade Impactor. Elemental and chemical analysis of HDPE-I revealed large amounts of sulfur, multiple metals (aluminum, magnesium, calcium, potassium, and iron), and high concentrations of toxic high molecular weight polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs), including the highly carcinogenic PAH benzo[c]fluorene. The overall carcinogenicity potential of HDPE-I PAHs, in benzo[a]pyrene equivalents (BaP<ce:inf loc=\"post\">Eq</ce:inf>), was 798.02<ce:hsp sp=\"0.25\"></ce:hsp>ng/m<ce:sup loc=\"post\">3</ce:sup>, orders of magnitude higher than that of other ambient anthropogenic nanoparticles. Exposure of THP-1 macrophages to HDPE-I increased cytotoxicity and reduced mitochondrial membrane potential, while also impairing phagocytosis by ~79%. RNA-seq analysis revealed activation of xenobiotic metabolism and stress-response pathways, particularly through AhR signaling, and altered expression of immune-related genes. These findings suggest that inhalation of MNPs emitted from plastic incineration may compromise alveolar macrophage function, increasing susceptibility to environmental particles and respiratory pathogens. Stricter waste management practices and regulatory policies are required to mitigate plastic burning emissions.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"21 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Precise toxicological mechanism of atherosclerosis (AS) induced by environmental hazardous substance nicotine exposure remains unclear, impeding its prevention strategies and antagonist development. Additionally, it is yet unknown whether Dendrobium officinale's active components can antagonize nicotine-induced AS. This study aimed to elucidate nicotine exposure-induced AS toxicological mechanisms and identify Dendrobium officinale's active components-derived antagonists. Firstly, using ApoE-/- mice AS model fed high-fat diet with nicotine, we confirmed that nicotine exposure can aggravate AS, while Dendrobium officinale extract (DOE) significantly alleviated it. Through multi-dimensional artificial intelligence analysis, we identified MMP9, CCR1, and HMOX1 as core targets of nicotine exposure-induced AS. Next, UPLC-Q-TOF-MS/MS identified 40 active components in DOE. Meanwhile, eight key DOE's active components were successfully screened as nicotine's potential antagonists. Furthermore, molecular dynamics simulations further validated the strong binding affinity of two representative antagonists, including L-tryptophan and citric acid, to nicotine-induced AS core targets. Finally, in vitro experiments and multivariate statistical analysis demonstrated that core targets mediated nicotine exposure-induced AS, while L-tryptophan and citric acid effectively inhibited them. Take together, MMP9, CCR1 and HMOX1 were crucial mediators of nicotine exposure-induced AS, effectively antagonized by erianin, nobilin D, naringenin, dihydroresveratrol, citric acid, syringic acid, vanillic acid and L-tryptophan from DOE's active components.
{"title":"Key toxicological targets identification for atherosclerosis induced by environmental hazardous substance nicotine exposure and its antagonists screening from active components of Dendrobium officinale","authors":"Heng Li, Yuhan Zhang, Qianqian Wang, Liwei Li, Guangzhen Zheng, Ruli Zheng, Tianjing Wang, Xiaoyao Yang, Zimeng Shi, Fengjiu Yang, Haiwei Kuai, Lijuan Cao, Qingping Xiong, Hui Yong, Yingying Shi","doi":"10.1016/j.jhazmat.2025.140799","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.140799","url":null,"abstract":"Precise toxicological mechanism of atherosclerosis (AS) induced by environmental hazardous substance nicotine exposure remains unclear, impeding its prevention strategies and antagonist development. Additionally, it is yet unknown whether <em>Dendrobium officinale</em>'s active components can antagonize nicotine-induced AS. This study aimed to elucidate nicotine exposure-induced AS toxicological mechanisms and identify <em>Dendrobium officinale</em>'s active components-derived antagonists. Firstly, using ApoE<sup>-/-</sup> mice AS model fed high-fat diet with nicotine, we confirmed that nicotine exposure can aggravate AS, while <em>Dendrobium officinale</em> extract (DOE) significantly alleviated it. Through multi-dimensional artificial intelligence analysis, we identified MMP9, CCR1, and HMOX1 as core targets of nicotine exposure-induced AS. Next, UPLC-Q-TOF-MS/MS identified 40 active components in DOE. Meanwhile, eight key DOE's active components were successfully screened as nicotine's potential antagonists. Furthermore, molecular dynamics simulations further validated the strong binding affinity of two representative antagonists, including L-tryptophan and citric acid, to nicotine-induced AS core targets. Finally, <em>in vitro</em> experiments and multivariate statistical analysis demonstrated that core targets mediated nicotine exposure-induced AS, while L-tryptophan and citric acid effectively inhibited them. Take together, MMP9, CCR1 and HMOX1 were crucial mediators of nicotine exposure-induced AS, effectively antagonized by erianin, nobilin D, naringenin, dihydroresveratrol, citric acid, syringic acid, vanillic acid and L-tryptophan from DOE's active components.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"36 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.jhazmat.2025.140807
Noah P. Germolus, Se-Na Kim, Juhee Kim, Chun Gwon Park
{"title":"Corrigendum to “Safety assessment of commercial sanitary pads: Cytotoxicity, volatile organic compounds, and microplastics release”[J. Hazard. Mater. 497 (2025) 139702]","authors":"Noah P. Germolus, Se-Na Kim, Juhee Kim, Chun Gwon Park","doi":"10.1016/j.jhazmat.2025.140807","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.140807","url":null,"abstract":"","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"15 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-15DOI: 10.1016/j.jhazmat.2025.140837
Yang Song, Shibin Zhang, Caihong Liu, Ziquan Zhao, Wen Qin, Jin Jiang, Jun Ma
In this study, orange peel and tea waste were successfully prepared into orange peel biochar (OBC) and tea waste biochar (TBC). OBC, TBC, and conventional corn straw biochar (CBC) were employed to facilitate the oxidative degradation of sulfamethoxazole (SMX) with ferrate (Fe(VI)) under neutral conditions (pH 7.0). The degradation of SMX was enhanced with the increase of the preparation temperature (400–600 °C) of OBC and TBC. The pyridine N on OBC and TBC dominated the enhancing degradation of SMX by Fe(VI) through an electron transfer pathway. OBC prepared at 600 °C (OBC600) was further modified by different Cu loading amounts. The degradation efficiency of SMX by Cu-loading/OBC600 was more significant than that by OBC600. H2O2 generated from the decay and oxidation of Fe(VI) was consumed by generated Cu(I) in Cu-loading/OBC600 followed by the generation of hydroxyl radical (•OH). This study established a novel strategy utilizing biochar while advancing mechanistic understanding of Fe(VI) activation processes, which was an environmentally friendly drinking water pre-treatment involving Fe(VI) and biochar and modified biochar.
{"title":"New insights into the role of biochar and Cu-biochar in enhanced degradation of sulfonamides by ferrate: Involvements of electron transfer and hydroxyl radical oxidation pathways","authors":"Yang Song, Shibin Zhang, Caihong Liu, Ziquan Zhao, Wen Qin, Jin Jiang, Jun Ma","doi":"10.1016/j.jhazmat.2025.140837","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.140837","url":null,"abstract":"In this study, orange peel and tea waste were successfully prepared into orange peel biochar (OBC) and tea waste biochar (TBC). OBC, TBC, and conventional corn straw biochar (CBC) were employed to facilitate the oxidative degradation of sulfamethoxazole (SMX) with ferrate (Fe(VI)) under neutral conditions (pH 7.0). The degradation of SMX was enhanced with the increase of the preparation temperature (400–600 °C) of OBC and TBC. The pyridine N on OBC and TBC dominated the enhancing degradation of SMX by Fe(VI) through an electron transfer pathway. OBC prepared at 600 °C (OBC600) was further modified by different Cu loading amounts. The degradation efficiency of SMX by Cu-loading/OBC600 was more significant than that by OBC600. H<ce:inf loc=\"post\">2</ce:inf>O<ce:inf loc=\"post\">2</ce:inf> generated from the decay and oxidation of Fe(VI) was consumed by generated Cu(I) in Cu-loading/OBC600 followed by the generation of hydroxyl radical (•OH). This study established a novel strategy utilizing biochar while advancing mechanistic understanding of Fe(VI) activation processes, which was an environmentally friendly drinking water pre-treatment involving Fe(VI) and biochar and modified biochar.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"68 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nickel (Ni) excessive accumulation in paddy soil threatens food security, but the redox transformation of manganese (Mn) and its regulatory mechanism on the environmental behavior of Ni remain unclear. In this study, we used rhizobag pot experiments with two rice cultivars with significantly different root oxygen loss (ROL) capacities, combined with continuous flooding (CF, reduction) and intermittent flooding (IF, oxidation) treatments, to investigate the effects of Mn(II) on soil Ni dissolution-release and rice accumulation. The results showed that Mn (II) influences Ni in a redox-dependent manner: during CF, Mn2+ promotes Ni release; under the dual drive of Mn(II)-oxidizing microorganisms and dissolved oxygen (IF), Mn(II) is transformed into Mn(III/IV) oxides, thereby immobilizing Ni. Additionally, Mn(II) addition promotes the formation of Fe plaque on root surfaces, enhancing Ni adsorption and increasing rice uptake and accumulation of Ni. The effect of dissolved Ni in soil on grain accumulation far exceeded the competitive inhibition of Mn2+. This study revealed the “double-edged sword” regulatory mechanism of Mn(II) on Ni in paddy soil, emphasizing that inhibiting the dissolution and release of Ni in soil is the key to controlling Ni accumulation in grains, providing a new perspective on the control of Ni pollution in paddy systems.
{"title":"The double-edged sword regulation mechanism of Mn(II) on Ni in paddy soil under redox conditions","authors":"Loua Augustin Bonaventure, Taicong Liu, Ruichun Meng, Rouyun Zhou, Fuliang Wang, Xiaoli Qian, Ming Ao, Jean-Louis Morel, Pan Wu, Shizhong Wang, Rongliang Qiu","doi":"10.1016/j.jhazmat.2025.140834","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.140834","url":null,"abstract":"Nickel (Ni) excessive accumulation in paddy soil threatens food security, but the redox transformation of manganese (Mn) and its regulatory mechanism on the environmental behavior of Ni remain unclear. In this study, we used rhizobag pot experiments with two rice cultivars with significantly different root oxygen loss (ROL) capacities, combined with continuous flooding (CF, reduction) and intermittent flooding (IF, oxidation) treatments, to investigate the effects of Mn(II) on soil Ni dissolution-release and rice accumulation. The results showed that Mn (II) influences Ni in a redox-dependent manner: during CF, Mn<ce:sup loc=\"post\">2+</ce:sup> promotes Ni release; under the dual drive of Mn(II)-oxidizing microorganisms and dissolved oxygen (IF), Mn(II) is transformed into Mn(III/IV) oxides, thereby immobilizing Ni. Additionally, Mn(II) addition promotes the formation of Fe plaque on root surfaces, enhancing Ni adsorption and increasing rice uptake and accumulation of Ni. The effect of dissolved Ni in soil on grain accumulation far exceeded the competitive inhibition of Mn<ce:sup loc=\"post\">2+</ce:sup>. This study revealed the “double-edged sword” regulatory mechanism of Mn(II) on Ni in paddy soil, emphasizing that inhibiting the dissolution and release of Ni in soil is the key to controlling Ni accumulation in grains, providing a new perspective on the control of Ni pollution in paddy systems.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"111 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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