Pub Date : 2025-01-10DOI: 10.1016/j.jhazmat.2025.137184
Jianli Qu, Weili Mao, Mei Chen, Hangbiao Jin
p-phenylenediamine antioxidants (PPDs) are extensively used in rubber manufacturing for their potent antioxidative properties, but PPDs and 2-anilino-5-[(4-methylpentan-2yl)amino]cyclohexa-2,5-diene-1,4-dione (6PPDQ) pose potential environmental and health risks. Existing biomonitoring methods for assessing human exposure to PPDs are labor-intensive, costly, and provide limited data. Thus, there is a critical need to develop predictive models for evaluating PPDs and 6PPDQ exposure levels to facilitate health risk assessments. In this study, machine learning (ML) models were developed to predict the concentration of three PPDs and 6PPDQ in human urine samples. A total of 759 participants from three cities in Zhejiang Province, China, provided urine samples, which were analyzed for PPDs and 6PPDQ concentrations using liquid chromatography-tandem mass spectrometry. Eight ML models were employed to predict PPDs and 6PPDQ concentrations based on demographic and environmental exposure factors such as age, gender, body mass index (BMI), and occupation. N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) was the most frequently detected PPD (mean 3.03 ng/mL, range < LOD–18.65 ng/mL), followed by 6PPDQ (mean 2.76 ng/mL, range < LOD–20.85 ng/mL) and N-phenyl-N'-cyclohexyl-p-phenylenediamine (mean 2.04 ng/mL, range < LOD–10.22 ng/mL). Random forest model demonstrated the highest accuracy in predicting PPDs and 6PPDQ concentrations in human urine among the ML models evaluated. Through the application of these models, age, BMI, and occupation emerged as significant predictors of urinary PPDs and 6PPDQ concentrations. This research significantly contributes by using ML models to enhance exposure assessment accuracy and efficiency, providing a novel framework for future studies on environmental health risks related to PPDs and 6PPDQ.
{"title":"Prediction of p-Phenylenediamine Antioxidant Concentrations in Human Urine Using Machine Learning Models","authors":"Jianli Qu, Weili Mao, Mei Chen, Hangbiao Jin","doi":"10.1016/j.jhazmat.2025.137184","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137184","url":null,"abstract":"<em>p</em>-phenylenediamine antioxidants (PPDs) are extensively used in rubber manufacturing for their potent antioxidative properties, but PPDs and 2-anilino-5-[(4-methylpentan-2yl)amino]cyclohexa-2,5-diene-1,4-dione (6PPDQ) pose potential environmental and health risks. Existing biomonitoring methods for assessing human exposure to PPDs are labor-intensive, costly, and provide limited data. Thus, there is a critical need to develop predictive models for evaluating PPDs and 6PPDQ exposure levels to facilitate health risk assessments. In this study, machine learning (ML) models were developed to predict the concentration of three PPDs and 6PPDQ in human urine samples. A total of 759 participants from three cities in Zhejiang Province, China, provided urine samples, which were analyzed for PPDs and 6PPDQ concentrations using liquid chromatography-tandem mass spectrometry. Eight ML models were employed to predict PPDs and 6PPDQ concentrations based on demographic and environmental exposure factors such as age, gender, body mass index (BMI), and occupation. N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) was the most frequently detected PPD (mean 3.03<!-- --> <!-- -->ng/mL, range < LOD–18.65<!-- --> <!-- -->ng/mL), followed by 6PPDQ (mean 2.76<!-- --> <!-- -->ng/mL, range < LOD–20.85<!-- --> <!-- -->ng/mL) and N-phenyl-N'-cyclohexyl-p-phenylenediamine (mean 2.04<!-- --> <!-- -->ng/mL, range < LOD–10.22<!-- --> <!-- -->ng/mL). Random forest model demonstrated the highest accuracy in predicting PPDs and 6PPDQ concentrations in human urine among the ML models evaluated. Through the application of these models, age, BMI, and occupation emerged as significant predictors of urinary PPDs and 6PPDQ concentrations. This research significantly contributes by using ML models to enhance exposure assessment accuracy and efficiency, providing a novel framework for future studies on environmental health risks related to PPDs and 6PPDQ.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"25 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-10DOI: 10.1016/j.jhazmat.2025.137188
Wei Xia, Dapeng Jiang, Jintao Liu, Jun Cai, Zhonghua Xi, Hu Yang
A series of novel cationic modified actinia-shaped composite coagulant (AMS-C), with similar tentacle length and distribution but different charge density (CD), was successfully designed and fabricated by combination of a cationic graft starch and attapulgite (ATP). AMS-C shows a high efficiency in coagulative removal of Microcystis aeruginosa from water over a wide pH range. The algae-harvesting efficiency of optimized AMS-C can reach to 92.27% only within 1.0 min after settlement and its maximal harvesting efficiency is as high as 99.25% at the optimum dosage of 1.5 mg/L. This can be attributed to its special composited structure with abundant cationic long tentacle chains. CD of AMS-C is a key structural factor. AMS-C with a relatively high CD obviously enhanced the coagulation efficiency and settling performance through the improved charge neutralization, besides, the distinct long tentacle chains of AMS-C allowed its easy accessibility and tightly contacted with the algal cells, and thus facilitated the formation of large, dense and fast regrowing algal flocs by the enhanced bridging and sweeping effects. The aforementioned effects were together contributed to the effective removal of algae. The effective interactions between microalga cells and the composite coagulants were also verified using extended Deryaguin-Landau-Verwey-Overbeek theory. Moreover, AMS-C was able to remove Microcystins-LR without destroying the cells, and still maintained a high algae-harvesting efficiency in real water bodies. Therefore, AMS-C, with the advantages of high-performance, environmentally-friendliness and low-cost, has notably promising application prospects in effective treatment of harmful algal blooms.
{"title":"Evaluation of the actinia-shaped composite coagulant for removal of algae in water: role of charge density","authors":"Wei Xia, Dapeng Jiang, Jintao Liu, Jun Cai, Zhonghua Xi, Hu Yang","doi":"10.1016/j.jhazmat.2025.137188","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137188","url":null,"abstract":"A series of novel cationic modified actinia-shaped composite coagulant (AMS-C), with similar tentacle length and distribution but different charge density (CD), was successfully designed and fabricated by combination of a cationic graft starch and attapulgite (ATP). AMS-C shows a high efficiency in coagulative removal of <em>Microcystis aeruginosa</em> from water over a wide pH range. The algae-harvesting efficiency of optimized AMS-C can reach to 92.27% only within 1.0<!-- --> <!-- -->min after settlement and its maximal harvesting efficiency is as high as 99.25% at the optimum dosage of 1.5<!-- --> <!-- -->mg/L. This can be attributed to its special composited structure with abundant cationic long tentacle chains. CD of AMS-C is a key structural factor. AMS-C with a relatively high CD obviously enhanced the coagulation efficiency and settling performance through the improved charge neutralization, besides, the distinct long tentacle chains of AMS-C allowed its easy accessibility and tightly contacted with the algal cells, and thus facilitated the formation of large, dense and fast regrowing algal flocs by the enhanced bridging and sweeping effects. The aforementioned effects were together contributed to the effective removal of algae. The effective interactions between microalga cells and the composite coagulants were also verified using extended Deryaguin-Landau-Verwey-Overbeek theory. Moreover, AMS-C was able to remove Microcystins-LR without destroying the cells, and still maintained a high algae-harvesting efficiency in real water bodies. Therefore, AMS-C, with the advantages of high-performance, environmentally-friendliness and low-cost, has notably promising application prospects in effective treatment of harmful algal blooms.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"31 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1016/j.jhazmat.2025.137121
Yuhang Wang, Hong Wang, Hui Ling, Changshou Hong, Xiangshuai Wang, Wenjun Lu, Qingmin Zhang, Ziqi Cai
The mechanism of radon exhalation from surrounding rock fracture has important guiding significance for radon prevention and control in underground research laboratories. The optimal ratio scheme of similar materials in the granite surrounding rock of Beishan underground laboratory was obtained by orthogonal test. The radon exhalation characteristics of fractured rock samples under dry and saturated conditions were obtained by using 10 standard joint roughness coefficient (JRC) curves. The radon exhalation rate of the dry sample and the saturated sample is linearly correlated with the JRC grade, and the radon exhalation rate of the dry sample is 82.65% higher than that of the saturated sample. There was a good correlation between fracture structure parameters (, SF, D0) and radon precipitation in fractured rock mass, which is helpful to reveal the mechanism of radon exhalation fromfractured rock mass.
{"title":"Preparation and radon exhalation characteristics of fracture granite similar materials in Beishan underground research laboratory","authors":"Yuhang Wang, Hong Wang, Hui Ling, Changshou Hong, Xiangshuai Wang, Wenjun Lu, Qingmin Zhang, Ziqi Cai","doi":"10.1016/j.jhazmat.2025.137121","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137121","url":null,"abstract":"The mechanism of radon exhalation from surrounding rock fracture has important guiding significance for radon prevention and control in underground research laboratories. The optimal ratio scheme of similar materials in the granite surrounding rock of Beishan underground laboratory was obtained by orthogonal test. The radon exhalation characteristics of fractured rock samples under dry and saturated conditions were obtained by using 10 standard joint roughness coefficient (JRC) curves. The radon exhalation rate of the dry sample and the saturated sample is linearly correlated with the JRC grade, and the radon exhalation rate of the dry sample is 82.65% higher than that of the saturated sample. There was a good correlation between fracture structure parameters (<span><span style=\"\"></span><span data-mathml='<math xmlns=\"http://www.w3.org/1998/Math/MathML\"><msub is=\"true\"><mrow is=\"true\"><mi is=\"true\">&#x3C3;</mi></mrow><mrow is=\"true\"><mi is=\"true\">i</mi></mrow></msub></math>' role=\"presentation\" style=\"font-size: 90%; display: inline-block; position: relative;\" tabindex=\"0\"><svg aria-hidden=\"true\" focusable=\"false\" height=\"1.74ex\" role=\"img\" style=\"vertical-align: -0.582ex;\" viewbox=\"0 -498.8 915.8 749.2\" width=\"2.127ex\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g fill=\"currentColor\" stroke=\"currentColor\" stroke-width=\"0\" transform=\"matrix(1 0 0 -1 0 0)\"><g is=\"true\"><g is=\"true\"><g is=\"true\"><use xlink:href=\"#MJMATHI-3C3\"></use></g></g><g is=\"true\" transform=\"translate(571,-150)\"><g is=\"true\"><use transform=\"scale(0.707)\" xlink:href=\"#MJMATHI-69\"></use></g></g></g></g></svg><span role=\"presentation\"><math xmlns=\"http://www.w3.org/1998/Math/MathML\"><msub is=\"true\"><mrow is=\"true\"><mi is=\"true\">σ</mi></mrow><mrow is=\"true\"><mi is=\"true\">i</mi></mrow></msub></math></span></span><script type=\"math/mml\"><math><msub is=\"true\"><mrow is=\"true\"><mi is=\"true\">σ</mi></mrow><mrow is=\"true\"><mi is=\"true\">i</mi></mrow></msub></math></script></span>, SF, D0) and radon precipitation in fractured rock mass, which is helpful to reveal the mechanism of radon exhalation fromfractured rock mass.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"19 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1016/j.jhazmat.2025.137172
Yubo Zhang, Pan Wang, Yu Tang, Chaosheng Liao, Xiaolong Tang, Pai Hou, Cheng Chen, Xiaokang Huang, Guangrou Lu, Lin Li, Mingjie Zhang, Fuxiang Li, Shihui Mei, Chao Chen, Ping Li
In agricultural production systems, the harm of both antibiotics and microplastics (MPs) to human health has been an important and continuously concerned issue. A small bagged silage production system was designed to investigate the effects of Lactoplantibacillus plantarum, polyethylene (PE) -MPs and their mixture on the silage fermentation and chemical composition of Tetracycline (TET) -contaminated whole plant maize. In addition, the bacterial community of silage samples was analyzed by using next generation genome sequencing technology. The formation of an extremely acidic environment (pH < 3.8) by ensiling effectively promoted the degradation of tetracycline (about 12.36 ng/mL), with PE-MPs particles also cleaved from 100 μm to 10 μm (in diameter) after 60 days of anaerobic storage. The PE-MPs physically adsorbed TET through its special pore structure and interacted with silage fermentation-dominated microorganisms including Lacticaseibacillus with relative abundances of 33-95%, where the combination of PE-MPs and L. plantarum degrades tetracycline to 7.05 ng/ml. The PE-MPs inclusion enhanced the fermentation function of Lacticaseibacillus and stabilized the pH, ammonia nitrogen and other chemical indices of silage mass. Importantly, the co-occurrence of PE-MPs sustained also the dominance of desirable Lacticaseibacillus at late stage of ensiling with TET-contaminated maize. Therefore, the combination of PE-MPs and L. plantarum counteracted undesirable silage fermentation from TET contamination, reduced hypothetically the risks to animal and even human health by unappreciated use of antibiotics in agricultural production system.
{"title":"Cooperation of Lactoplantibacillus plantarum and polyethylene microplastics facilitated the disappearance of tetracycline during anaerobic fermentation of whole plant maize","authors":"Yubo Zhang, Pan Wang, Yu Tang, Chaosheng Liao, Xiaolong Tang, Pai Hou, Cheng Chen, Xiaokang Huang, Guangrou Lu, Lin Li, Mingjie Zhang, Fuxiang Li, Shihui Mei, Chao Chen, Ping Li","doi":"10.1016/j.jhazmat.2025.137172","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137172","url":null,"abstract":"In agricultural production systems, the harm of both antibiotics and microplastics (MPs) to human health has been an important and continuously concerned issue. A small bagged silage production system was designed to investigate the effects of <em>Lactoplantibacillus plantarum</em>, polyethylene (PE) -MPs and their mixture on the silage fermentation and chemical composition of Tetracycline (TET) -contaminated whole plant maize. In addition, the bacterial community of silage samples was analyzed by using next generation genome sequencing technology. The formation of an extremely acidic environment (pH < 3.8) by ensiling effectively promoted the degradation of tetracycline (about 12.36<!-- --> <!-- -->ng/mL), with PE-MPs particles also cleaved from 100 μm to 10 μm (in diameter) after 60 days of anaerobic storage. The PE-MPs physically adsorbed TET through its special pore structure and interacted with silage fermentation-dominated microorganisms including <em>Lacticaseibacillus</em> with relative abundances of 33-95%, where the combination of PE-MPs and <em>L. plantarum</em> degrades tetracycline to 7.05<!-- --> <!-- -->ng/ml. The PE-MPs inclusion enhanced the fermentation function of <em>Lacticaseibacillus</em> and stabilized the pH, ammonia nitrogen and other chemical indices of silage mass. Importantly, the co-occurrence of PE-MPs sustained also the dominance of desirable <em>Lacticaseibacillus</em> at late stage of ensiling with TET-contaminated maize. Therefore, the combination of PE-MPs and <em>L. plantarum</em> counteracted undesirable silage fermentation from TET contamination, reduced hypothetically the risks to animal and even human health by unappreciated use of antibiotics in agricultural production system.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"31 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1016/j.jhazmat.2025.137170
Mei Dang, Longjiang Wu, Huaqing Bai, Chenxuan Yang, Qinqin Deng, Gelin Jin, Xiaoying Zhang
The increasing environmental prevalence of micro/nano plastics (MNPs) has raised significant concerns regarding their potential impact on human health, particularly in terms of immunotoxicity. However, the direct effects of MNPs on immune molecules, especially how they may influence protein liquid-liquid phase separation (LLPS)—a critical process implicated in various aspects of immune function—remain largely unexplored. This study addresses this gap by investigating the effects of polystyrene nanoparticles (PS NPs) with different surface modifications and sizes on LLPS in immunoglobulin Y (IgY) antibodies, critical components of the avian immune system. Our findings reveal that PS-COOH NPs uniquely induce LLPS in IgY in a size-dependent manner, while PS-NH2 and unmodified PS NPs do not. Furthermore, NP-induced LLPS disrupts IgY’s antigen-binding capability, potentially impairing immune responses. Notably, the IgY-Fc fragment shows a greater tendency for LLPS than the full-length antibody, suggesting broader implications for immune receptor interactions. These findings underscore the significant roles of nanoparticle surface chemistry, size, and antigen interactions in modulating LLPS. This study pioneers the exploration of MNPs-induced LLPS as a potential mechanism of immunotoxicity, providing crucial insights into the health risks posed by environmental MNPs and informing strategies for mitigation.
{"title":"Nanoplastic-Induced Antibody Liquid-liquid Phase Separation: Insights into Potential Immunotoxic Implications","authors":"Mei Dang, Longjiang Wu, Huaqing Bai, Chenxuan Yang, Qinqin Deng, Gelin Jin, Xiaoying Zhang","doi":"10.1016/j.jhazmat.2025.137170","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137170","url":null,"abstract":"The increasing environmental prevalence of micro/nano plastics (MNPs) has raised significant concerns regarding their potential impact on human health, particularly in terms of immunotoxicity. However, the direct effects of MNPs on immune molecules, especially how they may influence protein liquid-liquid phase separation (LLPS)—a critical process implicated in various aspects of immune function—remain largely unexplored. This study addresses this gap by investigating the effects of polystyrene nanoparticles (PS NPs) with different surface modifications and sizes on LLPS in immunoglobulin Y (IgY) antibodies, critical components of the avian immune system. Our findings reveal that PS-COOH NPs uniquely induce LLPS in IgY in a size-dependent manner, while PS-NH<sub>2</sub> and unmodified PS NPs do not. Furthermore, NP-induced LLPS disrupts IgY’s antigen-binding capability, potentially impairing immune responses. Notably, the IgY-Fc fragment shows a greater tendency for LLPS than the full-length antibody, suggesting broader implications for immune receptor interactions. These findings underscore the significant roles of nanoparticle surface chemistry, size, and antigen interactions in modulating LLPS. This study pioneers the exploration of MNPs-induced LLPS as a potential mechanism of immunotoxicity, providing crucial insights into the health risks posed by environmental MNPs and informing strategies for mitigation.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"38 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trisiloxane ethoxylates (TSEOn) have been found in multiple agro-environmental media due to their pervasive application in agricultural production. While some studies suggested that the differences in the toxicological effects of TSEOn were closely related to their end-capping groups, the environmental behaviors and fate of TSEOn congeners with varying end-capping groups in agroecosystems remain underexplored. This study investigated the dissipation patterns of 39 oligomers across three TSEOn congeners in cucumber, leaves, and soils through field trials, including TSEOn-H (hydroxy, n = 2 to 14), TSEOn-CH3 (methoxy, n = 2 to 14), and TSEOn-COCH3 (acetoxy, n = 3 to 15). All TSEOn oligomers dissipated following pseudo-first-order kinetics in cucumber, leaves, and soils with half-lives were 2.08-3.92 d, 1.77-4.44 d, and 5.06-19.80 d, respectively. TSEOn congeners in agro-environmental media presented different dissipation patterns affected by their end-capping groups. The interfacial behaviors of TSEOn-COCH3 in the leaves differed from those of TSEOn-H and TSEOn-CH3. The half-lives of TSEOn-H and TSEOn-CH3 congeners in soils were significantly positively correlated with log KOC, indicating that long-chain congeners preferentially partition to soil solid phases, leading to slower dissipation rates than short-chain congeners. Furthermore, long-chain TSEOn congeners may dissipate to short-chain congeners. The dietary risks of ΣTSEOn-CH3 intake through cucumber fruits were deemed safe for different Chinese populations based on the margin of exposure (MOE) assessment. This study alerts us to the environmental behaviors and fate of organosilicone surfactants and provides a baseline reference to the dietary exposure risks of TSEOn.
{"title":"Dissipation patterns of trisiloxane ethoxylates in cucumber plants and field soils: Insights from different end-capping groups","authors":"Simeng Li, Xiaohui Li, Chen Zhang, Bowen Li, Peiwen Yu, Qin Dai, Hongping Wang, Fen Jin","doi":"10.1016/j.jhazmat.2025.137167","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137167","url":null,"abstract":"Trisiloxane ethoxylates (TSEO<em>n</em>) have been found in multiple agro-environmental media due to their pervasive application in agricultural production. While some studies suggested that the differences in the toxicological effects of TSEO<em>n</em> were closely related to their end-capping groups, the environmental behaviors and fate of TSEO<em>n</em> congeners with varying end-capping groups in agroecosystems remain underexplored. This study investigated the dissipation patterns of 39 oligomers across three TSEO<em>n</em> congeners in cucumber, leaves, and soils through field trials, including TSEO<em>n</em>-H (hydroxy, <em>n</em> = 2 to 14), TSEO<em>n</em>-CH<sub>3</sub> (methoxy, <em>n</em> = 2 to 14), and TSEO<em>n</em>-COCH<sub>3</sub> (acetoxy, <em>n</em> = 3 to 15). All TSEO<em>n</em> oligomers dissipated following pseudo-first-order kinetics in cucumber, leaves, and soils with half-lives were 2.08-3.92 d, 1.77-4.44 d, and 5.06-19.80 d, respectively. TSEO<em>n</em> congeners in agro-environmental media presented different dissipation patterns affected by their end-capping groups. The interfacial behaviors of TSEO<em>n</em>-COCH<sub>3</sub> in the leaves differed from those of TSEO<em>n</em>-H and TSEO<em>n</em>-CH<sub>3</sub>. The half-lives of TSEO<em>n</em>-H and TSEO<em>n</em>-CH<sub>3</sub> congeners in soils were significantly positively correlated with log <em>K</em><sub>OC</sub>, indicating that long-chain congeners preferentially partition to soil solid phases, leading to slower dissipation rates than short-chain congeners. Furthermore, long-chain TSEO<em>n</em> congeners may dissipate to short-chain congeners. The dietary risks of ΣTSEO<em>n</em>-CH<sub>3</sub> intake through cucumber fruits were deemed safe for different Chinese populations based on the margin of exposure (MOE) assessment. This study alerts us to the environmental behaviors and fate of organosilicone surfactants and provides a baseline reference to the dietary exposure risks of TSEO<em>n</em>.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"89 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1016/j.jhazmat.2025.137166
Chunfeng Xie, Xinyao Jiang, Juan Yin, Runqiu Jiang, Jianyun Zhu, Shenshan Zou
Bisphenol S (BPS) is a widely detected environmental toxin with the potential to increase the risk of non-alcoholic fatty liver disease (NAFLD). However, the effects of BPS on the progression of high fat diet (HFD)-induced NAFLD remain unclear. This study aimed to explore the role and underlying mechanisms of action of BPS in HFD-induced NAFLD. Our results showed that BPS exposure (50 and 500 μg/kg bodyweight/day) promoted the progression of NAFLD, which was evidenced by increased liver/body weight ratio, elevated serum alanine aminotransferase and aspartate aminotransferase levels, and more and larger lipid droplets in liver tissues. These phenomena were accompanied by abnormal expression levels of fatty acid uptake (Cd36), fatty acid synthesis (Pparγ, Scd-1, and Fasn), fatty acid oxidation (Pparα), and cytokines (TNFα, IL-1β, and IL-6). In vitro and in vivo studies showed that BPS exposure caused hepatic ferroptosis by regulating ferroptosis-related markers (GPX4, xCT, FTH, and ACSL4). Moreover, BPS exposure caused ROS overproduction, mitochondrial dysfunction, lipid peroxidation, and GSH suppression, all of which were restored by ferrostatin-1, a ferroptosis inhibitor. Moreover, BPS significantly upregulated HMGCS2 expression in the hepatocytes and liver tissues. 3-hydroxy-3-methylglutaryl coenzyme A synthetase 2 (HMGCS2) knockdown mitigated the effects of BPS on hepatocytes and reverses the expression of ferroptosis-related markers. Thus, BPS exposure aggravates HFD-induced NAFLD by regulating HMGCS2-mediated ferroptosis. Collectively, our study indicates that BPS exposure at environmentally relevant concentrations may aggravate NAFLD phenotypes under HFD conditions, highlighting the health risks of BPS to the liver.
{"title":"Bisphenol S accelerates the progression of high fat diet-induced NAFLD by triggering ferroptosis via regulating HMGCS2","authors":"Chunfeng Xie, Xinyao Jiang, Juan Yin, Runqiu Jiang, Jianyun Zhu, Shenshan Zou","doi":"10.1016/j.jhazmat.2025.137166","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137166","url":null,"abstract":"Bisphenol S (BPS) is a widely detected environmental toxin with the potential to increase the risk of non-alcoholic fatty liver disease (NAFLD). However, the effects of BPS on the progression of high fat diet (HFD)-induced NAFLD remain unclear. This study aimed to explore the role and underlying mechanisms of action of BPS in HFD-induced NAFLD. Our results showed that BPS exposure (50 and 500<!-- --> <!-- -->μg/kg bodyweight/day) promoted the progression of NAFLD, which was evidenced by increased liver/body weight ratio, elevated serum alanine aminotransferase and aspartate aminotransferase levels, and more and larger lipid droplets in liver tissues. These phenomena were accompanied by abnormal expression levels of fatty acid uptake (<em>Cd36</em>), fatty acid synthesis (<em>Pparγ</em>, <em>Scd-1, and Fasn</em>), fatty acid oxidation (<em>Pparα</em>), and cytokines (<em>TNFα, IL-1β,</em> and <em>IL-6</em>). <em>In vitro</em> and <em>in vivo</em> studies showed that BPS exposure caused hepatic ferroptosis by regulating ferroptosis-related markers (GPX4, xCT, FTH, and ACSL4). Moreover, BPS exposure caused ROS overproduction, mitochondrial dysfunction, lipid peroxidation, and GSH suppression, all of which were restored by ferrostatin-1, a ferroptosis inhibitor. Moreover, BPS significantly upregulated HMGCS2 expression in the hepatocytes and liver tissues. 3-hydroxy-3-methylglutaryl coenzyme A synthetase 2 (HMGCS2) knockdown mitigated the effects of BPS on hepatocytes and reverses the expression of ferroptosis-related markers. Thus, BPS exposure aggravates HFD-induced NAFLD by regulating HMGCS2-mediated ferroptosis. Collectively, our study indicates that BPS exposure at environmentally relevant concentrations may aggravate NAFLD phenotypes under HFD conditions, highlighting the health risks of BPS to the liver.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"5 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nitrate pollution poses severe risks to aquatic ecosystems and human health. The electrocatalytic nitrate reduction reaction (NITRR) offers a promising environmental and economic solution for nitrate pollution treatment and nitrogen source recovery; however, it continues to experience limited efficiency in neutral electrolytes. This study explores the heterointerface activation effects of TiO2/Cu2O heterogeneous catalysts with rutile (R-TiO2) and anatase (A-TiO2) phases and reveals that R-TiO2 is an active crystal phase with high nitrate reduction performance. The R-TiO2/Cu2O catalyst removed 99.8% of nitrate in 180 min and achieved an ammonia yield of 0.23 mmol h-1 cm-2 with a Faraday efficiency of 85.7% in a neutral electrolyte. In situ characterisation and theoretical calculations revealed that heterointerface reconstruction and oxygen vacancy (OV) formation overcome the poor electrical conductivity of R-TiO2, enhance electron transfer, and optimize the active sites. Furthermore, the Cu-O-Ti bond at the interface significantly weakens the adsorption energy of the critical intermediate *NO3, thereby facilitating NITRR. This study provides new insights into crystal phase modulation in catalyst design and offers innovative strategies for developing highly efficient NITRR electrocatalysts, paving the way for sustainable nitrate pollution treatment and nitrogen source recovery.Environmental ImplicationNitrate enrichment in aquatic environments poses significant environmental and health threats, necessitating innovative solutions. This study introduces an R-TiO2/Cu2O heterogeneous catalyst driven by strategic crystalline phase modulation that demonstrates superior performance in the NITRR. The R-TiO2/Cu2O catalyst demonstrates superior nitrate reduction performance in neutral electrolytes, characterised by rapid kinetics and high ammonia selectivity. Its enhanced efficiency and stability make it a promising next-generation catalyst for addressing nitrate pollution through sustainable recovery and environmental protection, which are vital for advancing clean-water technologies.
{"title":"Unveiling Heterointerface Activation Effects with Different Titanium Dioxide Crystal Phases for Electrocatalytic Nitrate-to-Ammonia Reduction","authors":"Junxiao Wang, Wenxin Dong, Qinan Song, Shuo Zhang, Miao Li, Junchun Chen, Shihao Zhang, Jinsuo Lu","doi":"10.1016/j.jhazmat.2025.137174","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137174","url":null,"abstract":"Nitrate pollution poses severe risks to aquatic ecosystems and human health. The electrocatalytic nitrate reduction reaction (NITRR) offers a promising environmental and economic solution for nitrate pollution treatment and nitrogen source recovery; however, it continues to experience limited efficiency in neutral electrolytes. This study explores the heterointerface activation effects of TiO<sub>2</sub>/Cu<sub>2</sub>O heterogeneous catalysts with rutile (R-TiO<sub>2</sub>) and anatase (A-TiO<sub>2</sub>) phases and reveals that R-TiO<sub>2</sub> is an active crystal phase with high nitrate reduction performance. The R-TiO<sub>2</sub>/Cu<sub>2</sub>O catalyst removed 99.8% of nitrate in 180<!-- --> <!-- -->min and achieved an ammonia yield of 0.23<!-- --> <!-- -->mmol<!-- --> <!-- -->h<sup>-1</sup> cm<sup>-2</sup> with a Faraday efficiency of 85.7% in a neutral electrolyte. In situ characterisation and theoretical calculations revealed that heterointerface reconstruction and oxygen vacancy (O<sub>V</sub>) formation overcome the poor electrical conductivity of R-TiO<sub>2</sub>, enhance electron transfer, and optimize the active sites. Furthermore, the Cu-O-Ti bond at the interface significantly weakens the adsorption energy of the critical intermediate *NO<sub>3</sub>, thereby facilitating NITRR. This study provides new insights into crystal phase modulation in catalyst design and offers innovative strategies for developing highly efficient NITRR electrocatalysts, paving the way for sustainable nitrate pollution treatment and nitrogen source recovery.<strong>Environmental Implication</strong>Nitrate enrichment in aquatic environments poses significant environmental and health threats, necessitating innovative solutions. This study introduces an R-TiO<sub>2</sub>/Cu<sub>2</sub>O heterogeneous catalyst driven by strategic crystalline phase modulation that demonstrates superior performance in the NITRR. The R-TiO<sub>2</sub>/Cu<sub>2</sub>O catalyst demonstrates superior nitrate reduction performance in neutral electrolytes, characterised by rapid kinetics and high ammonia selectivity. Its enhanced efficiency and stability make it a promising next-generation catalyst for addressing nitrate pollution through sustainable recovery and environmental protection, which are vital for advancing clean-water technologies.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"19 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atrazine (ATR) is an endocrine disruptor known for its persistence and mobility. While the diffuse characteristics and potential risks of ATR have been extensively studied, its transregional migration and degradation characteristics have received less attention. In this study, a modified mass balance approach considering the diffuse source (DS), tributaries, water resource usage, degradation, adsorption, and evaporation was developed based on the traditional mass balance framework and field sampling to estimate the DS fluxes of ATR in a large river basin. Field sampling revealed that the ATR concentration in the surface water increased downstream, whereas the ATR levels in suspended particulate matter decreased. The ATR degradation ratio also decreased downstream, suggesting increased input along the river. The modified mass balance approach identified DS as the primary ATR source in the river, followed by tributaries. Together, the DS input and tributary inflow accounted for 95.6% ± 2.1% of the total ATR flux, with DS alone contributing 73.8% ± 10.2%. Finally, the ATR parent and its hazardous materials (ATR, desethylatrazine, and desisopropylatrazine) accounted for 6% and 27%, respectively, of the total ATR content that reached the estuary. This integrated consideration of ATR and its degradation products offer a new perspective on their transregional migration and degradation patterns resulting from diffuse pollution.
{"title":"Involving degradation products provides a new perspective of diffuse pollution assessment of atrazine with a modified mass balance approach","authors":"Zewei Guo, Wei Ouyang, Mengchang He, Siwei Peng, Jingyi Hu, Chunye Lin","doi":"10.1016/j.jhazmat.2025.137169","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137169","url":null,"abstract":"Atrazine (ATR) is an endocrine disruptor known for its persistence and mobility. While the diffuse characteristics and potential risks of ATR have been extensively studied, its transregional migration and degradation characteristics have received less attention. In this study, a modified mass balance approach considering the diffuse source (DS), tributaries, water resource usage, degradation, adsorption, and evaporation was developed based on the traditional mass balance framework and field sampling to estimate the DS fluxes of ATR in a large river basin. Field sampling revealed that the ATR concentration in the surface water increased downstream, whereas the ATR levels in suspended particulate matter decreased. The ATR degradation ratio also decreased downstream, suggesting increased input along the river. The modified mass balance approach identified DS as the primary ATR source in the river, followed by tributaries. Together, the DS input and tributary inflow accounted for 95.6% ± 2.1% of the total ATR flux, with DS alone contributing 73.8% ± 10.2%. Finally, the ATR parent and its hazardous materials (ATR, desethylatrazine, and desisopropylatrazine) accounted for 6% and 27%, respectively, of the total ATR content that reached the estuary. This integrated consideration of ATR and its degradation products offer a new perspective on their transregional migration and degradation patterns resulting from diffuse pollution.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"83 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1016/j.jhazmat.2025.137165
Wei Zhang, Juzheng Liu, Shoushu Liu, Saiwen Yang, Erjie Huang, Shaojie Ren, Lin Gong
The efficient removal of Mn(II) from wastewater is crucial for safeguarding water quality, yet existing adsorbents face significant challenges, including high costs, poor resistance to ionic interference, and scalability limitations. This study addresses these challenges by utilizing abundant natural sandy sediment (SS) as a substrate to load unsaturated MnOx via in-situ oxidation, creating a novel adsorbent (MOSS). MOSS exhibits a remarkable Mn(II) adsorption capacity of 1.35 mg·g-1, representing a 6-7-fold increase compared to SS. The unsaturated nature of MnOx in MOSS enables effective co-separation of transition metals, further enhancing its utility. It is observed that redox reactions, metal complex formation, and ions exchange processes may play a significant role in further enhancing its adsorption capacity and selectivity. In dynamic filtration tests, MOSS effectively maintains Mn(II) removal below 0.1 mg·L-1 after continuous effluent and retains over 50% separation efficiency after three regeneration cycles. And the byproducts of Mn(II) adsorption were successfully repurposed as a photo-thermal material for solar evaporator, achieving an evaporation rate of 1.97 kg·h-1·m-2 and a conversion efficiency of 98.64%. This study presents a cost-effective, scalable, and sustainable method for Mn(II) removal, while offering novel insights into the high-value utilization of MOSS byproducts for environmental remediation and resource recovery.
{"title":"Multi-effect synergistic induction of unsaturated MnOx on sandy sediment for enhanced manganese adsorption and byproduct resource recovery in solar evaporation","authors":"Wei Zhang, Juzheng Liu, Shoushu Liu, Saiwen Yang, Erjie Huang, Shaojie Ren, Lin Gong","doi":"10.1016/j.jhazmat.2025.137165","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137165","url":null,"abstract":"The efficient removal of Mn(II) from wastewater is crucial for safeguarding water quality, yet existing adsorbents face significant challenges, including high costs, poor resistance to ionic interference, and scalability limitations. This study addresses these challenges by utilizing abundant natural sandy sediment (SS) as a substrate to load unsaturated MnO<sub>x</sub> via in-situ oxidation, creating a novel adsorbent (MOSS). MOSS exhibits a remarkable Mn(II) adsorption capacity of 1.35<!-- --> <!-- -->mg·g<sup>-1</sup>, representing a 6-7-fold increase compared to SS. The unsaturated nature of MnO<sub>x</sub> in MOSS enables effective co-separation of transition metals, further enhancing its utility. It is observed that redox reactions, metal complex formation, and ions exchange processes may play a significant role in further enhancing its adsorption capacity and selectivity. In dynamic filtration tests, MOSS effectively maintains Mn(II) removal below 0.1<!-- --> <!-- -->mg·L<sup>-1</sup> after continuous effluent and retains over 50% separation efficiency after three regeneration cycles. And the byproducts of Mn(II) adsorption were successfully repurposed as a photo-thermal material for solar evaporator, achieving an evaporation rate of 1.97<!-- --> <!-- -->kg·h<sup>-1</sup>·m<sup>-2</sup> and a conversion efficiency of 98.64%. This study presents a cost-effective, scalable, and sustainable method for Mn(II) removal, while offering novel insights into the high-value utilization of MOSS byproducts for environmental remediation and resource recovery.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"204 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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