Pub Date : 2025-04-20DOI: 10.1016/j.jhazmat.2025.138349
Jiali Yan , Xuwei Li , Zhengguo Pan , Xiaochen Lin , Qinglin Zuo , Jiankang Zhou , Shiqi Zhou , Fuqing Sui , Lei Zhang , Matthew H.H. Fischel
Red mud is a highly alkaline industrial by-product rich in iron oxides with great potential for soil cadmium remediation. Although the stabilization of Cd by red mud is well reported in rice potted and field experiments, the influence of red mud on microbial communities in paddy soil and the contribution of soil microbial communities subjected to red mud in Cd stabilization remain unknown. This study used high-throughput sequencing and bioinformatics, combined with a sequential extraction procedure, to determine the microbiological mechanisms of rice Cd reduction by red mud and information on the corresponding soil Cd fraction. The results showed that red mud significantly increased the soil pH and iron and manganese oxide-bound Cd fractions. Red mud application influenced the microbial beta diversity rather than the alpha diversity, especially for bacteria. Unique taxa associated with iron reduction (e.g., phylum Firmicutes and genus Anaeromyxobacter) were enriched at the rice-filling stage, which may contribute to the stabilization of Cd. Red mud application caused little difference in the fungal communities. A 2 % red mud amendment successfully decreased the grain Cd content in a high Cd-accumulating rice cultivar by 72 %. Red mud effectively reduces Cd accumulation in the short-term and demonstrates potential for remedial applications. This study provides microbiological evidence for stabilizing Cd in red mud, but its long-term environmental impact and field applicability require further research.
{"title":"Red mud causes dynamic changes in the soil microbial community and cadmium fractions in a slightly cadmium-contaminated paddy soil","authors":"Jiali Yan , Xuwei Li , Zhengguo Pan , Xiaochen Lin , Qinglin Zuo , Jiankang Zhou , Shiqi Zhou , Fuqing Sui , Lei Zhang , Matthew H.H. Fischel","doi":"10.1016/j.jhazmat.2025.138349","DOIUrl":"10.1016/j.jhazmat.2025.138349","url":null,"abstract":"<div><div>Red mud is a highly alkaline industrial by-product rich in iron oxides with great potential for soil cadmium remediation. Although the stabilization of Cd by red mud is well reported in rice potted and field experiments, the influence of red mud on microbial communities in paddy soil and the contribution of soil microbial communities subjected to red mud in Cd stabilization remain unknown. This study used high-throughput sequencing and bioinformatics, combined with a sequential extraction procedure, to determine the microbiological mechanisms of rice Cd reduction by red mud and information on the corresponding soil Cd fraction. The results showed that red mud significantly increased the soil pH and iron and manganese oxide-bound Cd fractions. Red mud application influenced the microbial beta diversity rather than the alpha diversity, especially for bacteria. Unique taxa associated with iron reduction (e.g., phylum <em>Firmicutes</em> and genus <em>Anaeromyxobacter</em>) were enriched at the rice-filling stage, which may contribute to the stabilization of Cd. Red mud application caused little difference in the fungal communities. A 2 % red mud amendment successfully decreased the grain Cd content in a high Cd-accumulating rice cultivar by 72 %. Red mud effectively reduces Cd accumulation in the short-term and demonstrates potential for remedial applications. This study provides microbiological evidence for stabilizing Cd in red mud, but its long-term environmental impact and field applicability require further research.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"493 ","pages":"Article 138349"},"PeriodicalIF":12.2,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Disinfectants in the environment have important impacts on the occurrence of antibiotic resistant bacteria, posing a new threat to public health. Streptococcus suis (S. suis) can survive in the environment for three months and carries antibiotic resistance genes. However, it remains unclear whether disinfectants directly induce antibiotic resistance in S. suis. Here, we conducted induction experiments on the S. suis standard strain (CVCC609) with eight disinfectants at different concentrations and investigated their effects on the antibiotic resistance mechanism of S. suis. The results showed that only 64 mg L-1 peracetic acid (PAA) led to an increase (8-fold) in S. suis resistance to tiamulin (TIA) with genetic stability. The treatment also induced significant changes in the morphology and capsule of the mutant strains, as well as triggered an increase in reactive oxygen species and biofilms in bacterial cells, resulting in an emergency response. Moreover, PAA significantly decreased the cell membrane permeability and led to slight changes in the adenosine triphosphate level. The key differentially expressed genes are closely related to these resistance mechanisms. These results reveal the co-selection mechanism of S. suis resistance to PAA and TIA, and highlight the importance of standardized application of disinfectants in livestock and poultry farming.
{"title":"Environmental Peracetic Acid Increases Antibiotic Resistance in Streptococcus Suis","authors":"Wenjin Ma, Ziyan Kou, Mengya Fang, Meixia Huo, Xiangyue Xu, Xudong Lin, Lingli Huang","doi":"10.1016/j.jhazmat.2025.138353","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138353","url":null,"abstract":"Disinfectants in the environment have important impacts on the occurrence of antibiotic resistant bacteria, posing a new threat to public health. <em>Streptococcus suis</em> (<em>S. suis</em>) can survive in the environment for three months and carries antibiotic resistance genes. However, it remains unclear whether disinfectants directly induce antibiotic resistance in <em>S. suis</em>. Here, we conducted induction experiments on the <em>S. suis</em> standard strain (CVCC609) with eight disinfectants at different concentrations and investigated their effects on the antibiotic resistance mechanism of <em>S. suis</em>. The results showed that only 64<!-- --> <!-- -->mg<!-- --> <!-- -->L<sup>-1</sup> peracetic acid (PAA) led to an increase (8-fold) in <em>S. suis</em> resistance to tiamulin (TIA) with genetic stability. The treatment also induced significant changes in the morphology and capsule of the mutant strains, as well as triggered an increase in reactive oxygen species and biofilms in bacterial cells, resulting in an emergency response. Moreover, PAA significantly decreased the cell membrane permeability and led to slight changes in the adenosine triphosphate level. The key differentially expressed genes are closely related to these resistance mechanisms. These results reveal the co-selection mechanism of <em>S. suis</em> resistance to PAA and TIA, and highlight the importance of standardized application of disinfectants in livestock and poultry farming.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"17 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-18DOI: 10.1016/j.jhazmat.2025.138297
John Nightingale, Stefan Trapp, Andrea Garduño-Jiménez, Laura Carter
The reuse of treated wastewater for irrigation can inadvertently introduce a suite of emerging contaminants such as pharmaceuticals into agri-ecosystems. However, current monitoring efforts to characterize exposure usually focus on a limited range of analytes. A modelling framework was developed that employs a sequence of pre-developed models to predict accumulative potential in a model crop, Zea mays (corn), using chemical structure and excretion rate as the only model inputs. Z. mays was selected as the model crop as it is a major food source, stands as one of the highest cultivated crops globally, and is characterized as having a medium uptake potential. The framework was used to predict uptake in Z. mays in three regions characteristic of high wastewater reuse (Australia, the US and the Middle East). Despite regional and plant specific differences, 66.7% of the calculated concentrations were within a factor of ten of those reported in the literature. Topiramate, furosemide, and gemfibrozil were observed to accumulate to the greatest extent in Z. mays, predicted concentrations ranged between 50.27-418.0 (ng/g dw) for the top 10. Acids predominantly accumulated in leaves and fruit whereas a higher proportion of bases were predicted to accumulate in the roots. To the best of our knowledge 56.7% of the 30 highest-ranked pharmaceuticals have not been previously documented in existing literature or monitoring campaigns. This presented framework demonstrates a method to assess risk posed by pharmaceutical compounds with limited experimental data.
{"title":"A framework to assess pharmaceutical accumulation in crops: from wastewater irrigation to consumption","authors":"John Nightingale, Stefan Trapp, Andrea Garduño-Jiménez, Laura Carter","doi":"10.1016/j.jhazmat.2025.138297","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138297","url":null,"abstract":"The reuse of treated wastewater for irrigation can inadvertently introduce a suite of emerging contaminants such as pharmaceuticals into agri-ecosystems. However, current monitoring efforts to characterize exposure usually focus on a limited range of analytes. A modelling framework was developed that employs a sequence of pre-developed models to predict accumulative potential in a model crop, <em>Zea mays</em> (corn), using chemical structure and excretion rate as the only model inputs. <em>Z. mays</em> was selected as the model crop as it is a major food source, stands as one of the highest cultivated crops globally, and is characterized as having a medium uptake potential. The framework was used to predict uptake in <em>Z. mays</em> in three regions characteristic of high wastewater reuse (Australia, the US and the Middle East). Despite regional and plant specific differences, 66.7% of the calculated concentrations were within a factor of ten of those reported in the literature. Topiramate, furosemide, and gemfibrozil were observed to accumulate to the greatest extent in <em>Z. mays</em>, predicted concentrations ranged between 50.27-418.0 (ng/g dw) for the top 10. Acids predominantly accumulated in leaves and fruit whereas a higher proportion of bases were predicted to accumulate in the roots. To the best of our knowledge 56.7% of the 30 highest-ranked pharmaceuticals have not been previously documented in existing literature or monitoring campaigns. This presented framework demonstrates a method to assess risk posed by pharmaceutical compounds with limited experimental data.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"17 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-18DOI: 10.1016/j.jhazmat.2025.138336
Liping Tan , Rufei Gao , Yan Su , Yan Zhang , Yanqing Geng , Qiuju Liu , Yidan Ma , Xuemei Chen , Fangfang Li , Junlin He
Phthalate-induced female reproductive health issues, particularly those related to di (2-ethylhexyl) phthalate (DEHP), are growing global concerns. Although most studies have focused on single-generation exposure, studies on prolonged DEHP exposure across multiple generations are limited. This study assessed the effects of multigenerational DEHP exposure on endometrial decidualization, which is crucial for embryo implantation. The results showed that sustained DEHP exposure over three generations exacerbated decidualization injury and led to adverse pregnancy outcomes. RNA sequencing revealed upregulation of the imprinted gene Snurf in the decidua, with changes that may not depend on alterations in DNA methylation. Knockdown of Snurf significantly alleviated in vitro decidualization deficiency induced by mono(2-ethylhexyl) phthalate (MEHP), the biologically active metabolite of DEHP. Proteomic analysis and the AlphaFold 3 algorithm indicated that Stn1 is a downstream target of Snurf, with silencing Stn1 resensitizing Snurf-knockdown stromal cells to MEHP. Human decidual stromal cells (hDSCs) from healthy participants showed sensitivity to MEHP, with the inhibition of decidualization. Epidemiological data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) indicated a positive association between DEHP exposure and female infertility. This study highlighted the cumulative toxic effects of multigenerational DEHP exposure on female reproduction and revealed the contribution of imprinted genes.
{"title":"Multigenerational exposure to DEHP drives dysregulation of imprinted gene Snurf to impair decidualization","authors":"Liping Tan , Rufei Gao , Yan Su , Yan Zhang , Yanqing Geng , Qiuju Liu , Yidan Ma , Xuemei Chen , Fangfang Li , Junlin He","doi":"10.1016/j.jhazmat.2025.138336","DOIUrl":"10.1016/j.jhazmat.2025.138336","url":null,"abstract":"<div><div>Phthalate-induced female reproductive health issues, particularly those related to di (2-ethylhexyl) phthalate (DEHP), are growing global concerns. Although most studies have focused on single-generation exposure, studies on prolonged DEHP exposure across multiple generations are limited. This study assessed the effects of multigenerational DEHP exposure on endometrial decidualization, which is crucial for embryo implantation. The results showed that sustained DEHP exposure over three generations exacerbated decidualization injury and led to adverse pregnancy outcomes. RNA sequencing revealed upregulation of the imprinted gene <em>Snurf</em> in the decidua, with changes that may not depend on alterations in DNA methylation. Knockdown of <em>Snurf</em> significantly alleviated <em>in vitro</em> decidualization deficiency induced by mono(2-ethylhexyl) phthalate (MEHP), the biologically active metabolite of DEHP. Proteomic analysis and the AlphaFold 3 algorithm indicated that <em>Stn1</em> is a downstream target of <em>Snurf</em>, with silencing <em>Stn1</em> resensitizing <em>Snurf</em>-knockdown stromal cells to MEHP. Human decidual stromal cells (hDSCs) from healthy participants showed sensitivity to MEHP, with the inhibition of decidualization. Epidemiological data from the 2017–2018 National Health and Nutrition Examination Survey (NHANES) indicated a positive association between DEHP exposure and female infertility. This study highlighted the cumulative toxic effects of multigenerational DEHP exposure on female reproduction and revealed the contribution of imprinted genes.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"493 ","pages":"Article 138336"},"PeriodicalIF":12.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-18DOI: 10.1016/j.jhazmat.2025.138338
Jim Spain
{"title":"To the Editor: Conventions for reporting biodegradation rates","authors":"Jim Spain","doi":"10.1016/j.jhazmat.2025.138338","DOIUrl":"10.1016/j.jhazmat.2025.138338","url":null,"abstract":"","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"493 ","pages":"Article 138338"},"PeriodicalIF":12.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-18DOI: 10.1016/j.jhazmat.2025.138337
Rong Qin, Yiming Feng, Shasha Zhuo, Qing-Long Fu
Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has been extensively employed to characterize the chemodiversty of dissolved organic matter (DOM) including chlorinated disinfection byproducts (Cln-DBPs). However, little is known about the combined effects of the sequential solid phase extraction (SPE) and absorption mode of Fourier transform data processing on the identification of Cln-DBPs. In this study, the identification of Cln-DBPs by the sequential SPE extraction and absorption mode were systematically compared using a typical swimming pool water. The sequential SPE extraction was more effective in extracting DOM molecules including Cln-DBPs than the traditional extraction, yielding 48.2 % ± 2.1 % and 87.3 % ± 3.8 % more DOM molecules and Cln-DBPs molecules, respectively. Moreover, a total of 274 nitrogenous Cln-DBPs were identified by the sequential SPE extraction with 80 more than that by the traditional SPE. The absorption mode improved the resolution and the signal-to-noise values of DOM peaks by factors of 1.87–1.98 and 1.52–1.60, respectively. The number of resolved Cl-related mass doublets within 2 mDa mass difference in the absorption mode was 537 more than that in the magnitude mode. Overall, the combination of sequential elution and absorption modes facilitated the detection of more molecules of DOM and Cln-DBPs compared to traditional SPE in magnitude mode, with an increase of 92.7 % ± 2.1 % and 121.7 % ± 5.6 %, respectively. These results have highlighted the great potential of the sequential elution combined with absorption mode in improving the identification of Cln-DBPs and their precursors, facilitating the application of FT-ICR MS in the nontargeted analysis of emerging contaminants including Cln-DBPs at the molecular level.
{"title":"Improved identification of chlorinated disinfection byproducts by the sequential elution and absorption mode","authors":"Rong Qin, Yiming Feng, Shasha Zhuo, Qing-Long Fu","doi":"10.1016/j.jhazmat.2025.138337","DOIUrl":"10.1016/j.jhazmat.2025.138337","url":null,"abstract":"<div><div>Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has been extensively employed to characterize the chemodiversty of dissolved organic matter (DOM) including chlorinated disinfection byproducts (Cl<sub><em>n</em></sub>-DBPs). However, little is known about the combined effects of the sequential solid phase extraction (SPE) and absorption mode of Fourier transform data processing on the identification of Cl<sub><em>n</em></sub>-DBPs. In this study, the identification of Cl<sub><em>n</em></sub>-DBPs by the sequential SPE extraction and absorption mode were systematically compared using a typical swimming pool water. The sequential SPE extraction was more effective in extracting DOM molecules including Cl<sub><em>n</em></sub>-DBPs than the traditional extraction, yielding 48.2 % ± 2.1 % and 87.3 % ± 3.8 % more DOM molecules and Cl<sub><em>n</em></sub>-DBPs molecules, respectively. Moreover, a total of 274 nitrogenous Cl<sub><em>n</em></sub>-DBPs were identified by the sequential SPE extraction with 80 more than that by the traditional SPE. The absorption mode improved the resolution and the signal-to-noise values of DOM peaks by factors of 1.87–1.98 and 1.52–1.60, respectively. The number of resolved Cl-related mass doublets within 2 mDa mass difference in the absorption mode was 537 more than that in the magnitude mode. Overall, the combination of sequential elution and absorption modes facilitated the detection of more molecules of DOM and Cl<sub><em>n</em></sub>-DBPs compared to traditional SPE in magnitude mode, with an increase of 92.7 % ± 2.1 % and 121.7 % ± 5.6 %, respectively. These results have highlighted the great potential of the sequential elution combined with absorption mode in improving the identification of Cl<sub><em>n</em></sub>-DBPs and their precursors, facilitating the application of FT-ICR MS in the nontargeted analysis of emerging contaminants including Cl<sub><em>n</em></sub>-DBPs at the molecular level.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"493 ","pages":"Article 138337"},"PeriodicalIF":12.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microplastics (MPs) negatively impact various terrestrial animals, but their comprehensive effects on Gallus gallus domesticus, key agricultural and ecological species connecting people and the environment, are not well-documented. This study investigates the effects of polyethylene (PE) MPs and phthalate esters (PAEs) on chicken growth, liver metabolism, and gut microbiota using multi-omics and 16S rRNA sequencing technology. Results show that PE MPs, particularly those containing PAEs, significantly reduced body weight gain and hepatic triglyceride levels by up to 71.2 % and 50.1 %, respectively (p < 0.05). The clean MPs affected energy metabolism, while PAE-spiked MPs disrupted fatty acid metabolism and triggered immune and inflammatory responses in the liver. Key genes related to fatty acid metabolism such as FAN, SCD and ELOVL5 were significantly downregulated, leading to imbalances in lipid metabolism. These disruptions in PAE-spiked MPs exposure were associated with the altered gut microbiota balance, including increased Firmicutes/Bacteroidetes ratios and changes in Actinobacteriota and Proteobacteria abundance. Totally, the study highlights a "Trojan Horse" effect, where MPs act as carriers for PAEs, intensifying toxicity through gut-liver axis interactions. The findings emphasize the role of gut microbiota in mediating liver dysfunction and impaired growth.
{"title":"Polyethylene microplastics impair chicken growth through gut microbiota-induced hepatic fatty acid metabolism dysfunction","authors":"Jiaping Xu, Qiuyue Zhang, Yu Wang, Zhipeng Cheng, Hongkai Zhu, Hongzhi Zhao, Yiming Yao, Liting Hua, Biting Qiao, Leicheng Zhao, Yongcheng Li, Lei Wang, Hongwen Sun","doi":"10.1016/j.jhazmat.2025.138335","DOIUrl":"10.1016/j.jhazmat.2025.138335","url":null,"abstract":"<div><div>Microplastics (MPs) negatively impact various terrestrial animals, but their comprehensive effects on <em>Gallus gallus domesticus</em>, key agricultural and ecological species connecting people and the environment, are not well-documented. This study investigates the effects of polyethylene (PE) MPs and phthalate esters (PAEs) on chicken growth, liver metabolism, and gut microbiota using multi-omics and 16S rRNA sequencing technology. Results show that PE MPs, particularly those containing PAEs, significantly reduced body weight gain and hepatic triglyceride levels by up to 71.2 % and 50.1 %, respectively (<em>p</em> < 0.05). The clean MPs affected energy metabolism, while PAE-spiked MPs disrupted fatty acid metabolism and triggered immune and inflammatory responses in the liver. Key genes related to fatty acid metabolism such as FAN, SCD and ELOVL5 were significantly downregulated, leading to imbalances in lipid metabolism. These disruptions in PAE-spiked MPs exposure were associated with the altered gut microbiota balance, including increased <em>Firmicutes</em>/<em>Bacteroidetes</em> ratios and changes in <em>Actinobacteriota</em> and <em>Proteobacteria</em> abundance. Totally, the study highlights a \"Trojan Horse\" effect, where MPs act as carriers for PAEs, intensifying toxicity through gut-liver axis interactions. The findings emphasize the role of gut microbiota in mediating liver dysfunction and impaired growth.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"493 ","pages":"Article 138335"},"PeriodicalIF":12.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The environmental prevalence of the tire wear-derived emerging pollutant N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine-quinone (6PPD-Q) has increasingly raised public concern. However, knowledge of the adverse effects of 6PPD-Q on soil fauna is scarce. In this study, we elucidated its impact on soil fauna, specifically on the earthworm Eisenia fetida. Our investigation encompassed phenotypic, multi-omics, and microbiota analyses to assess earthworm responses to a gradient of 6PPD-Q contamination (10, 100, 1000, and 5000 μg/kg dw soil). Post-28-day exposure, 6PPD-Q was found to bioaccumulate in earthworms, triggering reactive oxygen species production and consequent oxidative damage to coelomic and intestinal tissues. Transcriptomic and metabolomic profiling revealed several physiological perturbations, including inflammation, immune dysfunction, metabolic imbalances, and genetic toxicity. Moreover, 6PPD-Q perturbed the intestinal microbiota, with high dosages significantly suppressing microbial functions linked to metabolism and information processing (P < 0.05). These alterations were accompanied by increased mortality and weight loss in the earthworms. Specifically, at an environmental concentration of 6PPD-Q (1000 μg/kg), we observed a substantial reduction in survival rate and physiological disruptions. This study provides important insights into the environmental hazards of 6PPD-Q to soil biota and reveals the underlying toxicological mechanisms, underscoring the need for further research to mitigate its ecological footprint.
{"title":"6PPD-quinone Exposure Induces Oxidative Damage and Physiological Disruption in Eisenia fetida: An Integrated Analysis of Phenotypes, Multi-omics, and Intestinal Microbiota","authors":"Hanghai Zhou, Zhou Wu, Xin Wang, Lijia Jiang, Hong Sun, Hua Li, Zhongyong Yan, Yuan Wang, Xiaohong Yao, Chunfang Zhang, Jiangwu Tang","doi":"10.1016/j.jhazmat.2025.138334","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138334","url":null,"abstract":"The environmental prevalence of the tire wear-derived emerging pollutant <em>N</em>-(1,3-dimethylbutyl)-<em>N'</em>-phenyl-<em>p</em>-phenylenediamine-quinone (6PPD-Q) has increasingly raised public concern. However, knowledge of the adverse effects of 6PPD-Q on soil fauna is scarce. In this study, we elucidated its impact on soil fauna, specifically on the earthworm <em>Eisenia fetida</em>. Our investigation encompassed phenotypic, multi-omics, and microbiota analyses to assess earthworm responses to a gradient of 6PPD-Q contamination (10, 100, 1000, and 5000<!-- --> <!-- -->μg/kg dw soil). Post-28-day exposure, 6PPD-Q was found to bioaccumulate in earthworms, triggering reactive oxygen species production and consequent oxidative damage to coelomic and intestinal tissues. Transcriptomic and metabolomic profiling revealed several physiological perturbations, including inflammation, immune dysfunction, metabolic imbalances, and genetic toxicity. Moreover, 6PPD-Q perturbed the intestinal microbiota, with high dosages significantly suppressing microbial functions linked to metabolism and information processing (<em>P</em> < 0.05). These alterations were accompanied by increased mortality and weight loss in the earthworms. Specifically, at an environmental concentration of 6PPD-Q (1000<!-- --> <!-- -->μg/kg), we observed a substantial reduction in survival rate and physiological disruptions. This study provides important insights into the environmental hazards of 6PPD-Q to soil biota and reveals the underlying toxicological mechanisms, underscoring the need for further research to mitigate its ecological footprint.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"1 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-18DOI: 10.1016/j.jhazmat.2025.138328
Yao Yu , Yan Wang , Darrell W.S. Tang , Sha Xue , Mengjuan Liu , Violette Geissen , Xiaomei Yang
The risks posed by biodegradable plastics to the plant-soil system have been increasingly studied due to potentially hazardous effects on soil properties and nutrient cycling. In this study, we investigated the effects of Poly (butylene adipate-co-terephthalate) microplastics (PBAT-MPs) on soil carbon, nitrogen and microbial communities under different levels of contamination (0 % (control), 0.1 %, 0.2 %, 0.5 % and 1 %), in soils planted with soybean (Glycine max (Linn.) Merr.) and maize (Zea mays L.). The results showed that PBAT-MPs significantly altered soil dissolved organic carbon, dissolved organic nitrogen and nitrate nitrogen contents, and that these effects varied by plant type and growth stage (p < 0.05). PBAT-MPs significantly increased soil microbial biomass carbon and nitrogen for both plants (p < 0.05), except for microbial biomass nitrogen at the soybean flowering stage. PBAT-MPs altered the β-diversity and composition of bacterial and fungal communities, increasing the relative abundances of Proteobacteria but decreasing the relative abundances of Acidobacteriota for both plants. FAPROTAX analysis showed that PBAT-MPs had significant effects on functional bacterial groups related to the nitrogen and carbon cycle, that varied by plant type and growth stage. These results suggest that biodegradable microplastics may have plant-specific effects on soil microbial communities and microbial metabolism, and thereby influence soil carbon and nitrogen cycling.
{"title":"Soil C-N and microbial community were altered by polybutylene adipate terephthalate microplastics","authors":"Yao Yu , Yan Wang , Darrell W.S. Tang , Sha Xue , Mengjuan Liu , Violette Geissen , Xiaomei Yang","doi":"10.1016/j.jhazmat.2025.138328","DOIUrl":"10.1016/j.jhazmat.2025.138328","url":null,"abstract":"<div><div>The risks posed by biodegradable plastics to the plant-soil system have been increasingly studied due to potentially hazardous effects on soil properties and nutrient cycling. In this study, we investigated the effects of Poly (butylene adipate-co-terephthalate) microplastics (PBAT-MPs) on soil carbon, nitrogen and microbial communities under different levels of contamination (0 % (control), 0.1 %, 0.2 %, 0.5 % and 1 %), in soils planted with soybean (<em>Glycine max</em> (<em>Linn.</em>) <em>Merr.</em>) and maize (<em>Zea mays L.</em>). The results showed that PBAT-MPs significantly altered soil dissolved organic carbon, dissolved organic nitrogen and nitrate nitrogen contents, and that these effects varied by plant type and growth stage (<em>p</em> < 0.05). PBAT-MPs significantly increased soil microbial biomass carbon and nitrogen for both plants (<em>p</em> < 0.05), except for microbial biomass nitrogen at the soybean flowering stage. PBAT-MPs altered the β-diversity and composition of bacterial and fungal communities, increasing the relative abundances of <em>Proteobacteria</em> but decreasing the relative abundances of <em>Acidobacteriota</em> for both plants. FAPROTAX analysis showed that PBAT-MPs had significant effects on functional bacterial groups related to the nitrogen and carbon cycle, that varied by plant type and growth stage. These results suggest that biodegradable microplastics may have plant-specific effects on soil microbial communities and microbial metabolism, and thereby influence soil carbon and nitrogen cycling.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"493 ","pages":"Article 138328"},"PeriodicalIF":12.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-18DOI: 10.1016/j.jhazmat.2025.138324
Yuxiao Zhu , Yongquan Zheng , Fengshou Dong , Xiaohu Wu , Xinglu Pan , Jun Xu
In 2009, fenaminstrobin was officially registered in China as a strobilurin pesticide, particularly developed for effectively controlling fungal diseases. Despite its widespread use, limited information is available regarding its environmental persistence and eco-toxicological profile. Herein, we comprehensively assess the abiotic and biotic transformations of fenaminstrobin, along with the associated ecological risks. Findings indicate that fenaminstrobin exhibits stability in water and soil under dark conditions; however, it undergoes substantial degradation when exposed to simulated sunlight, primarily due to the formation of photo-isomers. Furthermore, various factors within the water matrix that influence photo-degradation rates are revealed. Ten transformation products (TPs) are identified via high-resolution mass spectrometry in conjunction with suspect and non-target screening methodologies. Subsequently, a plausible transformation pathway is proposed based on the analysis of molecular functional groups and density functional theory (DFT) calculations. The pathway involves processes such as hydration, hydrolysis of chlorobenzene and oxime-ether, as well as redox reactions. Eco-toxicity assessments, integrating the predicted toxicity based on the Ecological Structure–Activity Relationship (ECOSAR) program with experimental data, reveal that certain TPs associated with fenaminstrobin remain highly toxic to aquatic organisms, albeit their ecological risk decreases over the course of its transformation. This study elucidates the transformation mechanisms and ecological risks of fenaminstrobin, providing critical insights for its effective and safe utilization.
{"title":"Insight into abiotic and biotic transformations of fenaminstrobin in water and soil: Kinetics, transformation mechanism and ecotoxicity","authors":"Yuxiao Zhu , Yongquan Zheng , Fengshou Dong , Xiaohu Wu , Xinglu Pan , Jun Xu","doi":"10.1016/j.jhazmat.2025.138324","DOIUrl":"10.1016/j.jhazmat.2025.138324","url":null,"abstract":"<div><div>In 2009, fenaminstrobin was officially registered in China as a strobilurin pesticide, particularly developed for effectively controlling fungal diseases. Despite its widespread use, limited information is available regarding its environmental persistence and eco-toxicological profile. Herein, we comprehensively assess the abiotic and biotic transformations of fenaminstrobin, along with the associated ecological risks. Findings indicate that fenaminstrobin exhibits stability in water and soil under dark conditions; however, it undergoes substantial degradation when exposed to simulated sunlight, primarily due to the formation of photo-isomers. Furthermore, various factors within the water matrix that influence photo-degradation rates are revealed. Ten transformation products (TPs) are identified via high-resolution mass spectrometry in conjunction with suspect and non-target screening methodologies. Subsequently, a plausible transformation pathway is proposed based on the analysis of molecular functional groups and density functional theory (DFT) calculations. The pathway involves processes such as hydration, hydrolysis of chlorobenzene and oxime-ether, as well as redox reactions. Eco-toxicity assessments, integrating the predicted toxicity based on the Ecological Structure–Activity Relationship (ECOSAR) program with experimental data, reveal that certain TPs associated with fenaminstrobin remain highly toxic to aquatic organisms, albeit their ecological risk decreases over the course of its transformation. This study elucidates the transformation mechanisms and ecological risks of fenaminstrobin, providing critical insights for its effective and safe utilization.</div></div>","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"493 ","pages":"Article 138324"},"PeriodicalIF":12.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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