As one of the most abundant microorganisms on Earth, Bathyarchaeia with diverse abilities to degrade complex organic carbon play a vital role in the global carbon cycle. However, the role of Bathyarchaeia in arsenic (As) metabolism and their contribution to As mobilization in aquifers remain unclear. In this study, we recovered 15 Bathyarchaeota metagenome-assembled genomes (MAGs) from metagenomes of borehole sediments in the Jianghan Plain (JHP), China. Together with 374 representative Bathyarchaeia MAGs from public databases, six As metabolism genes i.e. arrA, arsR, arsA, arsB, arsC (Trx) and arsM were identified, accounting for 4.4, 47.6, 20.3, 38.3, 37.5 and 49.4% of total Bathyarchaeia MAGs, respectively. Heterologous expression of multiple arsC and arsM genes of Bathyarchaeia MAGs obtained from JHP sediments validated their abilities for As(V) reduction and As(III) methylation at environmentally relevant As concentration. These results indicate that in addition to providing bioavailable carbon sources for other microbial functional populations, Bathyarchaeia directly participate in As mobilization in the JHP aquifer via As(V) reduction and As(III) methylation. The diversified distribution of arsC and arsM in the class Bathyarchaeia suggests that Bathyarchaeia contribute to As cycling in other As-rich environments, such as hot spring, saline lakes, marine hydrothermal sediments and soils.
{"title":"Arsenic mobilization by Bathyarchaeia in subsurface sediments at the Jianghan Plain, China","authors":"Zhou Jiang, Wenjie Fang, Yongguang Jiang, Yidan Hu, Yiran Dong, Ping Li, Liang Shi","doi":"10.1016/j.jhazmat.2025.138002","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138002","url":null,"abstract":"As one of the most abundant microorganisms on Earth, <em>Bathyarchaeia</em> with diverse abilities to degrade complex organic carbon play a vital role in the global carbon cycle. However, the role of <em>Bathyarchaeia</em> in arsenic (As) metabolism and their contribution to As mobilization in aquifers remain unclear. In this study, we recovered 15 <em>Bathyarchaeota</em> metagenome-assembled genomes (MAGs) from metagenomes of borehole sediments in the Jianghan Plain (JHP), China. Together with 374 representative <em>Bathyarchaeia</em> MAGs from public databases, six As metabolism genes i.e. <em>arrA</em>, <em>arsR</em>, <em>arsA</em>, <em>arsB</em>, <em>arsC</em> (Trx) and <em>arsM</em> were identified, accounting for 4.4, 47.6, 20.3, 38.3, 37.5 and 49.4% of total <em>Bathyarchaeia</em> MAGs, respectively. Heterologous expression of multiple <em>arsC</em> and <em>arsM</em> genes of <em>Bathyarchaeia</em> MAGs obtained from JHP sediments validated their abilities for As(V) reduction and As(III) methylation at environmentally relevant As concentration. These results indicate that in addition to providing bioavailable carbon sources for other microbial functional populations, <em>Bathyarchaeia</em> directly participate in As mobilization in the JHP aquifer via As(V) reduction and As(III) methylation. The diversified distribution of <em>arsC</em> and <em>arsM</em> in the class <em>Bathyarchaeia</em> suggests that <em>Bathyarchaeia</em> contribute to As cycling in other As-rich environments, such as hot spring, saline lakes, marine hydrothermal sediments and soils.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"10 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As biodegradable food contact materials (FCMs), polylactic acid (PLA) and poly(butylene adipate-co-terephthalate) (PBAT) may release oligomers into food and raise potential health concerns. This study investigated the migration characteristics and digestive behaviors of oligomers by combining food simulation migration experiments, an in vitro digestion model, and high-resolution mass spectrometry. Moreover, the effects of the migrants from both materials on gut microbiota were evaluated following in vitro colonic fermentation for 48 h. The results indicated that 51 PLA oligomers and 45 PBAT oligomers were released into food simulants, with the migration increasing with ethanol concentration. Cyclic oligomers exhibited higher migration than linear oligomers. During digestion, PLA oligomers were almost completely degraded, whereas PBAT oligomers increased, additionally, cyclic oligomers were more susceptible to degradation. Migrants from both materials exhibited cytotoxicity effect on Caco-2 cells, disrupted the gut microbiota homeostasis, affecting multiple metabolic pathways. Especially, the migrants from PBAT inhibited the production of acetic, butyric, and isobutyric acids, while reducing the degradation of propionic acid. Overall, PBAT may pose a greater hazard than PLA. In conclusion, based on a new perspective of “lifecycle”, this systematic study will contribute to a deeper understanding of the safety of PLA and PBAT when utilized as FCMs.
{"title":"Chemical Migration, Digestive Behaviors and Effect on Gut Microbiota of PLA and PBAT Oligomers","authors":"Guowei Ma, Xiaomeng Gao, Yuting Chen, Hanfei Li, Yiling Cui, Peixue Guo, Tingting Zhao, Feng Di","doi":"10.1016/j.jhazmat.2025.137988","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137988","url":null,"abstract":"As biodegradable food contact materials (FCMs), polylactic acid (PLA) and poly(butylene adipate-co-terephthalate) (PBAT) may release oligomers into food and raise potential health concerns. This study investigated the migration characteristics and digestive behaviors of oligomers by combining food simulation migration experiments, an <em>in vitro</em> digestion model, and high-resolution mass spectrometry. Moreover, the effects of the migrants from both materials on gut microbiota were evaluated following <em>in vitro</em> colonic fermentation for 48<!-- --> <!-- -->h. The results indicated that 51 PLA oligomers and 45 PBAT oligomers were released into food simulants, with the migration increasing with ethanol concentration. Cyclic oligomers exhibited higher migration than linear oligomers. During digestion, PLA oligomers were almost completely degraded, whereas PBAT oligomers increased, additionally, cyclic oligomers were more susceptible to degradation. Migrants from both materials exhibited cytotoxicity effect on Caco-2 cells, disrupted the gut microbiota homeostasis, affecting multiple metabolic pathways. Especially, the migrants from PBAT inhibited the production of acetic, butyric, and isobutyric acids, while reducing the degradation of propionic acid. Overall, PBAT may pose a greater hazard than PLA. In conclusion, based on a new perspective of “lifecycle”, this systematic study will contribute to a deeper understanding of the safety of PLA and PBAT when utilized as FCMs.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"25 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-18DOI: 10.1016/j.jhazmat.2025.137964
Jie Tang, Tingting Cai, Na Li, Zexi Chen, Jintong Liu, Hong Yang
The extensive application of organophosphorus pesticides (OPs), in agricultural pest management has led to pervasive residue accumulation, posing substantial risks to the environment and human health. This study presented an environmentally friendly approach for chlorpyrifos detection using a Mn(III)-blocked aggregation-induced emission (AIE)-based metal-organic framework (MOF) nanosystem. Attributed to the inhibitory effect of chlorpyrifos on ascorbate oxidase (AAox), ascorbic acid was abundant with the restriction of oxidation by AAox and reduced Mn(III) in MOF. The redox reaction prompted the collapse of MOF and the release of AIEgens. Free AIEgens reassembled into emissive aggregates in the aqueous solution with significantly enhanced fluorescence signal through AIE. The enhanced luminescence enabled the sensitive detection of chlorpyrifos with a detection limit of 3.79 ng mL-1, as confirmed by recovery tests with food samples. The efficacy of sensor in tracking chlorpyrifos bioaccumulation in wheat underscored the potential for practical application in the residue monitoring within crops. This work introduced a highly sensitive AIE-MOF-based fluorescence sensing and environmentally friendly method for chlorpyrifos detection in crops, which was crucial for ensuring food and environmental safety.
{"title":"Target-induced dissociation of AIE metal-organic framework for fluorescence-enhanced determination of the chlorpyrifos bioaccumulation in wheat by employing Mn (III) as the active center","authors":"Jie Tang, Tingting Cai, Na Li, Zexi Chen, Jintong Liu, Hong Yang","doi":"10.1016/j.jhazmat.2025.137964","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137964","url":null,"abstract":"The extensive application of organophosphorus pesticides (OPs), in agricultural pest management has led to pervasive residue accumulation, posing substantial risks to the environment and human health. This study presented an environmentally friendly approach for chlorpyrifos detection using a Mn(III)-blocked aggregation-induced emission (AIE)-based metal-organic framework (MOF) nanosystem. Attributed to the inhibitory effect of chlorpyrifos on ascorbate oxidase (AAox), ascorbic acid was abundant with the restriction of oxidation by AAox and reduced Mn(III) in MOF. The redox reaction prompted the collapse of MOF and the release of AIEgens. Free AIEgens reassembled into emissive aggregates in the aqueous solution with significantly enhanced fluorescence signal through AIE. The enhanced luminescence enabled the sensitive detection of chlorpyrifos with a detection limit of 3.79<!-- --> <!-- -->ng<!-- --> <!-- -->mL<sup>-1</sup>, as confirmed by recovery tests with food samples. The efficacy of sensor in tracking chlorpyrifos bioaccumulation in wheat underscored the potential for practical application in the residue monitoring within crops. This work introduced a highly sensitive AIE-MOF-based fluorescence sensing and environmentally friendly method for chlorpyrifos detection in crops, which was crucial for ensuring food and environmental safety.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"126 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-18DOI: 10.1016/j.jhazmat.2025.137962
Frank Menger, Mara Römerscheid, Stefan Lips, Ole Klein, Deedar Nabi, Jürgen Gandrass, Hanna Joerss, Katrin Wendt-Potthoff, Daria Bedulina, Tristan Zimmermann, Mechthild Schmitt-Jansen, Carolin Huber, Alexander Böhme, Nadin Ulrich, Aaron J. Beck, Daniel Pröfrock, Eric P. Achterberg, Annika Jahnke, Lars Hildebrandt
The authors regret to inform, that there was an error in the author list of the article. Frank Menger and Mara Römerscheid share the first authorship of this manuscript. Additionally, the affiliation of Annika Jahnke and Lars Hildebrandt were mixed up in the footnotes * and * *. The correct list of authors should state:
{"title":"Erratum to “Screening the release of chemicals and microplastic particles from diverse plastic consumer products into water under accelerated UV weathering conditions” [J Hazard Mater 477 (2024) 135256]","authors":"Frank Menger, Mara Römerscheid, Stefan Lips, Ole Klein, Deedar Nabi, Jürgen Gandrass, Hanna Joerss, Katrin Wendt-Potthoff, Daria Bedulina, Tristan Zimmermann, Mechthild Schmitt-Jansen, Carolin Huber, Alexander Böhme, Nadin Ulrich, Aaron J. Beck, Daniel Pröfrock, Eric P. Achterberg, Annika Jahnke, Lars Hildebrandt","doi":"10.1016/j.jhazmat.2025.137962","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137962","url":null,"abstract":"The authors regret to inform, that there was an error in the author list of the article. Frank Menger and Mara Römerscheid share the first authorship of this manuscript. Additionally, the affiliation of Annika Jahnke and Lars Hildebrandt were mixed up in the footnotes * and * *. The correct list of authors should state:","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"19 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although cadmium (Cd) hyperaccumulators have been widely used in phytoremediation of Cd-contaminated soils, the relationship between soil phosphorus (P) uptake and Cd accumulation during phytoremediation remains unclear. In this study, a phosphate-solubilizing bacterium (PSB), Enterobacter sp., and the Cd hyperaccumulator B. pilosa L. were selected to address this knowledge gap. Our results show that Enterobacter sp. inoculation enhances P cycling processes in the rhizosphere of B. pilosa L., resulting in an increase in soil available phosphorus (AP), by 16.2% to 84.3% in low-contaminated soil and by 17.6% to 64.8% in high-contaminated soil. Inorganic P solubilization was the primary process driving the increase in AP content, contributing the most to soil P cycling. Moreover, Enterobacter sp. inoculation significantly promoted the growth of B. pilosa L., boosting total phosphorus, phospholipids, primary metabolic phosphorus, and Cd concentrations in plant tissues. Notably, a strong positive correlation was observed between soil AP and Cd concentrations in plant tissues. P-functional microbes in the rhizosphere, encoding genes such as gcd, ppa, and ppx-gppA, predominantly enhance P bioavailability in soils. Furthermore, in P-deficient and heavily contaminated soils, Proteobacteria replaced Actinobacteria as the predominant hosts for key genes involved in soil P cycling. This study provides valuable insights into the critical link between P availability and Cd accumulation, emphasizing the role of P cycling in enhancing Cd accumulation during phytoremediation mediated by PSB.
{"title":"Phosphate-solubilizing bacteria facilitate rhizospheric processes of Bidens pilosa L. in the phytoremediation of cadmium-contaminated soil: Link between phosphorus availability and cadmium accumulation","authors":"Yi Li, Shiyu Luo, Yiyun Fu, Chijian Tang, Xiaoxiao Qin, Dongyi Shi, Wei Lan, Yingxuan Tang, Fangming Yu","doi":"10.1016/j.jhazmat.2025.137997","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137997","url":null,"abstract":"Although cadmium (Cd) hyperaccumulators have been widely used in phytoremediation of Cd-contaminated soils, the relationship between soil phosphorus (P) uptake and Cd accumulation during phytoremediation remains unclear. In this study, a phosphate-solubilizing bacterium (PSB), <em>Enterobacter</em> sp., and the Cd hyperaccumulator <em>B. pilosa</em> L. were selected to address this knowledge gap. Our results show that <em>Enterobacter</em> sp. inoculation enhances P cycling processes in the rhizosphere of <em>B. pilosa</em> L., resulting in an increase in soil available phosphorus (AP), by 16.2% to 84.3% in low-contaminated soil and by 17.6% to 64.8% in high-contaminated soil. Inorganic P solubilization was the primary process driving the increase in AP content, contributing the most to soil P cycling. Moreover, <em>Enterobacter</em> sp. inoculation significantly promoted the growth of <em>B. pilosa</em> L., boosting total phosphorus, phospholipids, primary metabolic phosphorus, and Cd concentrations in plant tissues. Notably, a strong positive correlation was observed between soil AP and Cd concentrations in plant tissues. P-functional microbes in the rhizosphere, encoding genes such as <em>gcd</em>, <em>ppa</em>, and <em>ppx-gppA</em>, predominantly enhance P bioavailability in soils. Furthermore, in P-deficient and heavily contaminated soils, Proteobacteria replaced Actinobacteria as the predominant hosts for key genes involved in soil P cycling. This study provides valuable insights into the critical link between P availability and Cd accumulation, emphasizing the role of P cycling in enhancing Cd accumulation during phytoremediation mediated by PSB.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"34 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benzene emissions from industrial processes are a significant target for catalytic oxidation. Additionally, VOC emissions often contain heteroatoms such as chlorine, which can deactivate noble metal-based catalysts. The development of a cost-effective, environmentally friendly noble metal-based catalyst that resists chlorine poisoning is crucial. While Ag-based catalysts offer advantages in terms of cost and activity, Ag0 nanoparticles as active centers can be easily poisoned by chlorine. To address this challenge, we introduced a ternary catalyst of Ag-MnOx/CeO2, which combines support modification with MnO2 and Ag active center modification to Ag2O. The synergistic interaction among these components promotes the formation of Ag2O species, significantly enhancing the benzene oxidation performance. Moreover, the combination of Ag2O and MnO2 imparts strong resistance to chlorobenzene poisoning. Through characterization, performance testing, and theoretical analysis, Ag-MnOx/CeO2 demonstrated superior benzene oxidation and chlorine resistance compared with Ag/CeO2 catalysts. This study provides a promising avenue for developing more efficient and sustainable catalysts to address the pressing issue of VOC removal and mitigate chlorine poisoning in noble metal catalysts.
{"title":"Synergistic Effects of Ag-MnOx/CeO2 for Improved Benzene Oxidation and Chlorine Tolerance","authors":"Lingyun Guo, Xuehong Zhang, Wenjie Xia, Lijuan Liu, Xiaowei Zhang, Cibin Xu, Zhiwei Huang, Xiaomin Wu, Huawang Zhao, Guohua Jing, Huazhen Shen","doi":"10.1016/j.jhazmat.2025.138001","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.138001","url":null,"abstract":"Benzene emissions from industrial processes are a significant target for catalytic oxidation. Additionally, VOC emissions often contain heteroatoms such as chlorine, which can deactivate noble metal-based catalysts. The development of a cost-effective, environmentally friendly noble metal-based catalyst that resists chlorine poisoning is crucial. While Ag-based catalysts offer advantages in terms of cost and activity, Ag<sup>0</sup> nanoparticles as active centers can be easily poisoned by chlorine. To address this challenge, we introduced a ternary catalyst of Ag-MnO<sub>x</sub>/CeO<sub>2</sub>, which combines support modification with MnO<sub>2</sub> and Ag active center modification to Ag<sub>2</sub>O. The synergistic interaction among these components promotes the formation of Ag<sub>2</sub>O species, significantly enhancing the benzene oxidation performance. Moreover, the combination of Ag<sub>2</sub>O and MnO<sub>2</sub> imparts strong resistance to chlorobenzene poisoning. Through characterization, performance testing, and theoretical analysis, Ag-MnO<sub>x</sub>/CeO<sub>2</sub> demonstrated superior benzene oxidation and chlorine resistance compared with Ag/CeO<sub>2</sub> catalysts. This study provides a promising avenue for developing more efficient and sustainable catalysts to address the pressing issue of VOC removal and mitigate chlorine poisoning in noble metal catalysts.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"14 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-18DOI: 10.1016/j.jhazmat.2025.137963
Di Pan, Pan Chu, Xiongfei Fu, Diya Wen, Hua Song, Shupei Bai, Xuan Guo
The high-voltage electrostatic field (HVEF) has been proposed as an efficient and convenient strategy for microbial inactivation, playing a crucial role in ensuring urban safety and people’s lives and health. However, the effects of the underlying antibacterial molecular mechanism on specific functional capabilities are largely unknown. Here, we systematically investigated the molecular mechanism underlying the inactivation effect of an HVEF against E. coli with a wire-plate-type device. Our experimental analysis revealed that the antibacterial effects primarily stemmed from the local alteration of cell membrane integrity and permeability, which further induced a series of oxidative damage events, including decreased SOD activity, increased ROS levels and MDA content, and, eventually, apoptosis. Theoretically, this process is mediated mainly by energy metabolism, cell motility and membrane transport signalling, as suggested by a multiomic analysis. Through quantitative methods, we showed that FliC, a key flagellar protein, plays a very important role in this process and that the quantity of fliC present on cells influences the HVEF tolerance. These results together reveal the previously unknown mechanism underlying the antibacterial effect of HVEFs and suggest that fliC activity and cell motility are novel components of this mechanism that distinguish HVEF-resistant bacteria from normal bacteria.
{"title":"Elucidating the underlying mechanism of the bactericidal effect facilitated by a crucial flagellar protein under high-voltage electrostatic conditions","authors":"Di Pan, Pan Chu, Xiongfei Fu, Diya Wen, Hua Song, Shupei Bai, Xuan Guo","doi":"10.1016/j.jhazmat.2025.137963","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137963","url":null,"abstract":"The high-voltage electrostatic field (HVEF) has been proposed as an efficient and convenient strategy for microbial inactivation, playing a crucial role in ensuring urban safety and people’s lives and health. However, the effects of the underlying antibacterial molecular mechanism on specific functional capabilities are largely unknown. Here, we systematically investigated the molecular mechanism underlying the inactivation effect of an HVEF against <em>E. coli</em> with a wire-plate-type device. Our experimental analysis revealed that the antibacterial effects primarily stemmed from the local alteration of cell membrane integrity and permeability, which further induced a series of oxidative damage events, including decreased SOD activity, increased ROS levels and MDA content, and, eventually, apoptosis. Theoretically, this process is mediated mainly by energy metabolism, cell motility and membrane transport signalling, as suggested by a multiomic analysis. Through quantitative methods, we showed that FliC<em>,</em> a key flagellar protein, plays a very important role in this process and that the quantity of <em>fliC</em> present on cells influences the HVEF tolerance. These results together reveal the previously unknown mechanism underlying the antibacterial effect of HVEFs and suggest that <em>fliC</em> activity and cell motility are novel components of this mechanism that distinguish HVEF-resistant bacteria from normal bacteria.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"56 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to explore the metabolite profiles of populations engaged in intensive vegetable cultivation and their exposure to pesticides. As urbanization progresses and eating habits evolve, intensive vegetable farming has rapidly expanded; however, this cultivation method poses potential health risks to farmers, particularly due to long-term exposure to “greenhouse gases” in enclosed environments. The study investigated the demographic characteristics of individuals in vegetable-growing areas, collected relevant biological samples, and assessed exposure levels by analyzing pesticide metabolites in urine. The results indicated that the types and concentrations of pesticide metabolites detected in the urine of the exposed group were significantly higher than those in the control group, with notable increases in neonicotinoid metabolites such as dinotefuran (DIN) and thiacloprid. Furthermore, the impact of these pesticides on mammalian organisms was examined through animal experiments, which revealed dynamic changes in the concentration of DIN in mouse serum and urine, providing valuable data on its biological metabolic characteristics. These findings underscore the importance of ongoing disease prevention, pollution control, and the need for enhanced health monitoring and protective measures for agricultural workers.
{"title":"An Occupational Health Assessment of Dinotefuran Exposure in Greenhouse Vegetable Workers: Metabolomic Profiling and Toxicokinetic Analysis","authors":"Jiamin Li, Hao Zhang, Ke Zhao, Chengcheng Han, Changjian Li, Lei Fang, Haiyong Jia, Yong Wang, Hanqiu Tang, Qingfeng Zhai, Peng Xue","doi":"10.1016/j.jhazmat.2025.137989","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137989","url":null,"abstract":"This study aimed to explore the metabolite profiles of populations engaged in intensive vegetable cultivation and their exposure to pesticides. As urbanization progresses and eating habits evolve, intensive vegetable farming has rapidly expanded; however, this cultivation method poses potential health risks to farmers, particularly due to long-term exposure to “greenhouse gases” in enclosed environments. The study investigated the demographic characteristics of individuals in vegetable-growing areas, collected relevant biological samples, and assessed exposure levels by analyzing pesticide metabolites in urine. The results indicated that the types and concentrations of pesticide metabolites detected in the urine of the exposed group were significantly higher than those in the control group, with notable increases in neonicotinoid metabolites such as dinotefuran (DIN) and thiacloprid. Furthermore, the impact of these pesticides on mammalian organisms was examined through animal experiments, which revealed dynamic changes in the concentration of DIN in mouse serum and urine, providing valuable data on its biological metabolic characteristics. These findings underscore the importance of ongoing disease prevention, pollution control, and the need for enhanced health monitoring and protective measures for agricultural workers.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"61 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.jhazmat.2025.137947
Jiyun Kang, Cong Minh Tran, Handule Lee, Seong Soon Kim, Sung-Hee Cho, Myeongae Bae, Kwangsik Park, Ki-Tae Kim
Alternative phthalates (APs) have been developed due to the reported adverse effects of conventional phthalates (CPs). However, whether APs are nontoxic and can replace CPs remains controversial due to their endocrine-disrupting (ED) effects. Herein, to investigate the ED potential of diethyl-hexyl-cyclohexane (DEHCH), a newly developed non-phthalate-structured AP, we employed in silico (molecular docking simulation), in vitro (cell-based assays for estrogen and androgen receptors), and in vivo (zebrafish embryo model) methods. We also compared the results with two CPs (di(2-ethylhexyl) phthalate [DEHP] and diisononyl phthalate [DINP]) and two previously proposed non-phthalate-structured APs (1,2-cyclohexane dicarboxylic acid diisononyl ester [DINCH] and di-2-ethylhexyl terephthalate [DEHTP]). DEHCH did not exhibit the highest binding affinity for any of the five receptors such as estrogen, androgen, glucocorticoid receptors, and thyroid receptor alpha and beta. None of the tested phthalates exhibited agonistic or antagonistic effects on estrogen and androgen receptors. In zebrafish larvae, DEHCH did not affect the expression of the nine endocrine-related genes and neurobehaviors, which correlates well with the lack of changes in the endogenous concentrations of the five neurosteroids. In contrast, DINCH, DEHP, and DEHTP induced hyperactivity, and except for DEHCH, four phthalates significantly upregulated at least one gene. In addition, DINCH significantly increased the expression of cortisol and DEHP increased progesterone, allopregnanolone, and cortisol. These findings demonstrate that DEHCH is safer than CPs and the previously proposed APs in terms of ED effects, including neuronal system dysregulation.
{"title":"Diethyl-hexyl-cyclohexane (Eco-DEHCH) is a safer phthalate alternative that does not elicit neuroendocrine disrupting effects","authors":"Jiyun Kang, Cong Minh Tran, Handule Lee, Seong Soon Kim, Sung-Hee Cho, Myeongae Bae, Kwangsik Park, Ki-Tae Kim","doi":"10.1016/j.jhazmat.2025.137947","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137947","url":null,"abstract":"Alternative phthalates (APs) have been developed due to the reported adverse effects of conventional phthalates (CPs). However, whether APs are nontoxic and can replace CPs remains controversial due to their endocrine-disrupting (ED) effects. Herein, to investigate the ED potential of diethyl-hexyl-cyclohexane (DEHCH), a newly developed non-phthalate-structured AP, we employed <em>in silico</em> (molecular docking simulation), <em>in vitro</em> (cell-based assays for estrogen and androgen receptors), and <em>in vivo</em> (zebrafish embryo model) methods. We also compared the results with two CPs (di(2-ethylhexyl) phthalate [DEHP] and diisononyl phthalate [DINP]) and two previously proposed non-phthalate-structured APs (1,2-cyclohexane dicarboxylic acid diisononyl ester [DINCH] and di-2-ethylhexyl terephthalate [DEHTP]). DEHCH did not exhibit the highest binding affinity for any of the five receptors such as estrogen, androgen, glucocorticoid receptors, and thyroid receptor alpha and beta. None of the tested phthalates exhibited agonistic or antagonistic effects on estrogen and androgen receptors. In zebrafish larvae, DEHCH did not affect the expression of the nine endocrine-related genes and neurobehaviors, which correlates well with the lack of changes in the endogenous concentrations of the five neurosteroids. In contrast, DINCH, DEHP, and DEHTP induced hyperactivity, and except for DEHCH, four phthalates significantly upregulated at least one gene. In addition, DINCH significantly increased the expression of cortisol and DEHP increased progesterone, allopregnanolone, and cortisol. These findings demonstrate that DEHCH is safer than CPs and the previously proposed APs in terms of ED effects, including neuronal system dysregulation.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"61 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.jhazmat.2025.137993
Lai Wei, Ya Yang, Hongwen Gao, Rui Wang, Feng Cao, Qinghui Huang
This study investigated the biogeochemical dynamics influencing the distribution of organophosphorus flame retardants (OPFRs) from the Changjiang Estuary to the adjacent East China Sea, a region characterized by pronounced physicochemical gradients. Twelve out of thirteen OPFR congeners, including traditional and emerging OPFRs, were detected in sediments and seawater samples. Tris(2-chloroethyl) phosphate (TCEP) and tris(2-chloroisopropyl) phosphate (TCIPP) were the dominant congeners. Intensive relationships emerged between OPFR concentrations and biogeochemical parameters. Turbidity maximum zone (TMZ) was identified as a critical hotspot for OPFR pollution. Elevated OPFR levels in nutrient-rich upwelling and offshore regions suggest linkages to biological processes and potential ecological impacts. Furthermore, OPFR concentrations in seawater displayed inverse correlations with tidal fluctuations, highlighting hydrodynamic influences on contaminant dispersal. Based on the relationship between biogeochemical parameters and OPFR concentrations, a Random Forest (RF) model was developed to project OPFR concentrations for the year 2100 under a high-emission climate-change scenario (RCP 8.5). The prediction results were marginally lower compared to current conditions, and temperature emerged as the most significant driver of future OPFRs changes. Notably, emerging OPFRs presented comparable ecological risk to traditional OPFRs, which should be a concern in future regulations.
{"title":"Biogeochemical Impact on the Distribution Variations of Organophosphorus Flame Retardants in Estuarine Area and Insight into Climate Change","authors":"Lai Wei, Ya Yang, Hongwen Gao, Rui Wang, Feng Cao, Qinghui Huang","doi":"10.1016/j.jhazmat.2025.137993","DOIUrl":"https://doi.org/10.1016/j.jhazmat.2025.137993","url":null,"abstract":"This study investigated the biogeochemical dynamics influencing the distribution of organophosphorus flame retardants (OPFRs) from the Changjiang Estuary to the adjacent East China Sea, a region characterized by pronounced physicochemical gradients. Twelve out of thirteen OPFR congeners, including traditional and emerging OPFRs, were detected in sediments and seawater samples. Tris(2-chloroethyl) phosphate (TCEP) and tris(2-chloroisopropyl) phosphate (TCIPP) were the dominant congeners. Intensive relationships emerged between OPFR concentrations and biogeochemical parameters. Turbidity maximum zone (TMZ) was identified as a critical hotspot for OPFR pollution. Elevated OPFR levels in nutrient-rich upwelling and offshore regions suggest linkages to biological processes and potential ecological impacts. Furthermore, OPFR concentrations in seawater displayed inverse correlations with tidal fluctuations, highlighting hydrodynamic influences on contaminant dispersal. Based on the relationship between biogeochemical parameters and OPFR concentrations, a Random Forest (RF) model was developed to project OPFR concentrations for the year 2100 under a high-emission climate-change scenario (RCP 8.5). The prediction results were marginally lower compared to current conditions, and temperature emerged as the most significant driver of future OPFRs changes. Notably, emerging OPFRs presented comparable ecological risk to traditional OPFRs, which should be a concern in future regulations.","PeriodicalId":361,"journal":{"name":"Journal of Hazardous Materials","volume":"61 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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