Numerous deep learning (DL) models have been introduced to enhance the reliability of hydrological predictions. Recent studies demonstrate that leveraging large training datasets can substantially improve generalization performance by providing greater opportunities to capture fundamental processes. However, indiscriminate use of all available data in training regional DL models may compromise performance at the local scale. This study addresses this challenge by developing an enhanced network model that leverages cross-basin data. We introduce a novel heterogeneous weighting strategy designed to optimize DL model training for individual basins. The strategy quantifies the influence of one basin’s gradient on the loss of a target basin, thereby offering insights into inter-basin relationships. The strategy was evaluated using 531 basins from the CAMELS-US dataset and an additional 1,147 basins from the CAMELS-DE dataset as reference data. Results reveal that regional pooling models frequently suffer from local performance degradation, whereas the proposed heterogeneous weighting method delivers improved predictions. Compared with the conventional homogeneous weighting strategy, which treats all basins equally, our approach achieved a 0.028 increase in median Kling–Gupta Efficiency, a difference that is statistically significant at the 99.9% confidence level. Importantly, results modeling over 1,678 basins across two countries show that carefully designed training strategies provide greater gains than simply adding additional input variables to the network. Overall, our findings highlight the necessity of frameworks that explicitly account for basin-specific characteristics. By doing so, the proposed strategy advances predictive capabilities at both local and global scales.
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