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2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems最新文献

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Design of Readout Circuits Used for Micro-machined Capacitive Accelerometer 微机械电容式加速度计读出电路设计
Xiaowei Liu, Haifeng Zhang, Guangming Li, Weiping Chen, Xilian Wang
This paper describes a closed-loop micro-machined accelerometer implemented in a bulk-micromachining technology with integrated CMOS circuit. The operational principle of accelerometer is detailed. We establish a mathematical model of closed-loop system to compare the performance with the open accelerometer. Electrostatic force is served as a negative feedback in closed-loop operating mode to improve the bandwidth, linearity and dynamic range of micro-machined capacitive accelerometer. The noise source affected readout circuit is discussed to optimize circuit structure. The circuit is simulated using Hspice. The result of the circuit simulation shows good sensitivity and low power consumption. The sensor is designed to measure plusmn5g acceleration. Device sensitivity is larger than 15mV/g.
本文介绍了一种采用集成CMOS电路的微机械加工技术实现的闭环微机械加速度计。详细介绍了加速度计的工作原理。建立了闭环系统的数学模型,并与开式加速度计进行了性能比较。在闭环工作模式下,静电力作为负反馈,提高了微加工电容式加速度计的带宽、线性度和动态范围。讨论了噪声源对读出电路的影响,优化了读出电路的结构。利用Hspice对电路进行了仿真。仿真结果表明,该电路灵敏度高,功耗低。该传感器被设计用来测量加速度。器件灵敏度大于15mV/g。
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引用次数: 6
Heterogeneous Vesicle Arrays for Biosensing Applications 生物传感应用的异质囊泡阵列
M. Bally, B. Stadler, D. Grieshaber, J. Voros
Microarrays play a key-role in life sciences and in diagnostics by providing a powerful tool for high throughput parallel analysis of complex samples. We present a novel approach to create heterogeneous vesicle arrays with optimized interface chemistry and low unspecific response. Here, complexes of biotinylated single-stranded DNA and streptavidin are spotted onto a non-fouling biotinylated polymer layer. The so-obtained DNA array is then transformed into a vesicle array after incubation with a solution of nanoobjects tagged with the complementary strands. Phospholipid vesicle arrays can potentially be transformed into membrane protein arrays.
微阵列通过为复杂样品的高通量并行分析提供强大的工具,在生命科学和诊断中发挥着关键作用。我们提出了一种新的方法来创建具有优化界面化学和低非特异性反应的异质囊泡阵列。在这里,生物素化单链DNA和链亲和素的复合物被发现在一个没有污染的生物素化聚合物层上。然后,用带有互补链标记的纳米物体溶液孵育后,将获得的DNA阵列转化为囊泡阵列。磷脂囊泡阵列有可能转化为膜蛋白阵列。
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引用次数: 0
Nanoparticle SnO2 Gas Sensor with Circuit and Micro Heater on Chip Fabricated Using CMOS-MEMS Technique 采用CMOS-MEMS技术制作带有电路和微加热器的纳米二氧化锡气体传感器
C. Dai, Mao-Chen Liu
The fabrication of a carbon monoxide (CO) micro gas sensor integrated with an inverting amplifier circuit and a micro heater on chip using the commercial 0.35mum complementary metal oxide semiconductor (CMOS) process and a post-process have been implemented. The gas sensor is composed of a polysilicon resistor and a CO gas sensing film. Tin dioxide prepared by the sol-gel method is adopted as the CO gas sensing film. The micro heater is used to provide the working temperature of the gas sensor. The gas sensor, which is a resistive type sensor, changes the resistance when the sensing film adsorbs CO gas. The inverting amplifier circuit is utilized to convert the resistance of the gas sensor into the voltage output. Experimental results show that the sensitivity of the CO gas sensor is about 1 mV/ppm.
采用商用0.35 μ m互补金属氧化物半导体(CMOS)工艺和后处理工艺,实现了一种集成反相放大电路和片上微加热器的一氧化碳(CO)微气体传感器的制造。该气体传感器由多晶硅电阻器和CO气敏膜组成。采用溶胶-凝胶法制备的二氧化锡作为CO气敏膜。微加热器用于提供气体传感器的工作温度。该气体传感器为电阻式传感器,当感测膜吸附CO气体时,其电阻发生变化。利用反相放大电路将气体传感器的电阻转换为电压输出。实验结果表明,该CO气体传感器的灵敏度约为1 mV/ppm。
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引用次数: 18
Local Synthesis of Single-walled Carbon Nanotubes on Zeolite-covered Silicon Substrate by Laser-heating Chemical Vapor Depositon 激光加热化学气相沉积在沸石覆盖的硅衬底上局部合成单壁碳纳米管
Y. Jin, K. Kasuya, K. Nagato, H. Morii, T. Ooi, M. Nakao
Single-walled carbon nanotubes (SWNTs) have been locally synthesized on zeolite-covered silicon substrates by laser-heating chemical vapor deposition (CVD). We used laser irradiation as a heat source, Fe/Co nanoparticles supported on zeolite as catalysts, and ethanol vapor as a carbon source. We heated the zeolite catalysts using a Nd:YAG laser at 50 mW with a spot size of about 5mum diameter and synthesized SWNTs in a local area of about 20mum diameter at the irradiation point. We also synthesized SWNTs in a line by scanning the laser irradiation at 800mW at an average speed of 10mum/s. The synthesized SWNTs were characterized by scanning electron microscopy and Raman spectroscopy. To investigate the effect of heating SWNTs by the laser, we irradiated pure SWNTs synthesized by standard CVD in a vacuum furnace using the laser. Furthermore, we succeeded in bridging zeolite islands using SWNTs by laser-irradiating one side of the islands.
采用激光加热化学气相沉积(CVD)技术在沸石覆盖的硅衬底上局部合成了单壁碳纳米管。我们采用激光照射作为热源,沸石上负载的Fe/Co纳米颗粒作为催化剂,乙醇蒸汽作为碳源。我们使用Nd:YAG激光在50 mW的光斑尺寸约为5mum直径的条件下加热沸石催化剂,并在照射点的局部区域合成了约20mum直径的swcnts。在800mW的激光照射下,以10mum/s的平均速度扫描,合成了一条线的单壁碳纳米管。用扫描电镜和拉曼光谱对合成的单壁碳纳米管进行了表征。为了研究激光加热单壁碳纳米管的效果,我们在真空炉中使用激光照射标准CVD合成的纯单壁碳纳米管。此外,我们通过激光照射岛屿的一侧,成功地使用swnt桥接沸石岛屿。
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引用次数: 0
Cell Migration Driven by a Mechanical Stiffness Gradient 机械刚度梯度驱动的细胞迁移
Juhee Hong, Jinseok Kim, Jeongeun Baek, M. Cha, Junghoon Lee, Sukho Park
This paper reports the migration of cells along the gradient of mechanical stiffness when the cells are cultured on a flexible substrate with variable rigidity. The thickness difference of PDMS layer was used to create a stiffness gradient between a stiff (7 mum) and a soft (2 mum) region. A fabrication process was developed to minimize the effect of other factors such as height difference and surface chemistry variation that can affect the pattern of cell migration. A cultured embryonic carcinoma cells on the flexible substrate coated with fibronectin, and observed that most of cells were accumulated on the stiffer region. Patterns in various shapes and sizes with stiffness difference were tested to investigate the migratory behavior of the cells. The results suggest that our approach provides a key technology to study the mechanism of cell migration by durotaxis.
本文报道了当细胞在可变刚度的柔性基质上培养时,细胞沿机械刚度梯度的迁移。利用PDMS层的厚度差在硬区(7 μ m)和软区(2 μ m)之间产生刚度梯度。开发了一种制造工艺,以尽量减少其他因素的影响,如高度差和表面化学变化,可以影响细胞迁移的模式。在涂有纤维连接蛋白的柔性底物上培养胚胎癌细胞,观察到大部分细胞聚集在较硬的区域。测试了不同形状和大小的具有刚度差异的图案,以研究细胞的迁移行为。结果表明,我们的方法为研究细胞的硬趋向性迁移机制提供了关键技术。
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引用次数: 2
A Monolithically Fabricated Combinatorial Mixer for Microchip-Based High-Throughput Cell Culturing Assays 用于微芯片高通量细胞培养试验的单片制造组合混合器
M.C. Liu, D. Ho, Y. Tai
We present an integrated method to fabricate 3D microfluidic networks and fabricated the first on-chip cell culture device with an integrated combinatorial mixer. The combinatorial mixer is designed for screening the combinatorial effects of different compounds on cells. The monolithic fabrication method with parylene C as the basic structural material allows us to avoid wafer bonding and achieves precise alignment between microfluidic channels. As a proof-of-concept, we fabricated a device with a three-input combinatorial mixer and demonstrated that the mixer can produce all the possible combinations. Also, we demonstrated the ability to culture cells on-chip and performed a simple cell assay on-chip using trypan blue to stain dead cells.
我们提出了一种制造三维微流控网络的集成方法,并制造了第一个带有集成组合混合器的片上细胞培养装置。组合混合器用于筛选不同化合物对细胞的组合作用。以聚对二甲苯为基本结构材料的单片制造方法可以避免晶圆键合,实现微流控通道之间的精确对齐。作为概念验证,我们制作了一个带有三输入组合混频器的设备,并证明该混频器可以产生所有可能的组合。此外,我们展示了在芯片上培养细胞的能力,并在芯片上使用台锥蓝染色死细胞进行了简单的细胞试验。
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引用次数: 1
Micro Mass Spectrometer Using Triode Electron Emitters with a Planar Carbon-Nanoparticle Cathode as Ion Source 以平面碳纳米颗粒阴极为离子源的三极管电子发射器的微质谱计
J. Cho, H. Yoon, K. Jung, Sangsik Yang, K. Koh, Soonil Lee
Using micromachining techniques, a miniature time-of-flight mass spectrometer (TOF-MS) was fabricated which consisted of ion-source and ion-separator plates. The dimension of the assembled device was 11 mm times 11 mm times1.1 mm. The key part of the ion source was a triode electron emitter with a planar carbon-nanoparticle (CNP) cathode. CNP was one of the best cathode materials to build triode electron emitters because of the smooth surface morphology of CNP films in addition to their excellent emission characteristics which allowed low turn-on gate voltage and stable operation. The operation of each plate was confirmed successfully through separate tests. In particular, ion generation was verified via electron bombardment for ambient air and acetone molecules.
采用微加工技术,制作了由离子源和离子隔板组成的微型飞行时间质谱仪。组装后的器件尺寸为11mm × 11mm × 1.1 mm。离子源的关键部分是平面碳纳米颗粒(CNP)阴极的三极管电子发射器。CNP薄膜表面光滑,具有良好的发射特性,具有低导通栅极电压和稳定的工作性能,是构建三极管电子发射器的最佳正极材料之一。通过单独的试验,成功地确认了每个板的操作。特别是,通过电子轰击对环境空气和丙酮分子进行了离子生成验证。
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引用次数: 1
Effect of the electric field on the linear polarization property of binary quantum dots 电场对二元量子点线极化特性的影响
N. C. Swe, S. Suraprapapich, C. Wissawinthanon, S. Panyakeow
The splitting and shifting of eigen-energy levels of coupled binary quantum dots was theoretically studied. The amount of splitting as a function of applied electric field strength, in particular, was investigated. The eigen-energy of the system was calculated from the time-independent Schrodinger equation using a finite-difference method. It was found that a larger electric field leads to a larger amount of eigen-energy splitting. Since the degree of linear polarization is related to the amount of splitting of the eigen-energies, we can expect that the binary quantum dots should exhibit a stronger degree of linear polarization with increasing applied electric field.
从理论上研究了耦合二元量子点本征能级的分裂和移位。特别是,研究了劈裂量与外加电场强度的关系。用有限差分法从与时间无关的薛定谔方程计算了系统的本征能量。结果表明,电场越大,本征能分裂量越大。由于线极化的程度与本征能量的分裂量有关,我们可以预期,随着外加电场的增加,二元量子点的线极化程度应该更强。
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引用次数: 0
Microfilter Fabricated with PDMS and PES Membrane Applicable for Implantable Artificial Kidney 应用于植入式人工肾的PDMS和PES膜微过滤器
Y. Gu, N. Miki
We present a novel microfilter used for solutes separation by diffusion. The microfilter is composed of two micro chambers made of PDMS and one layer of porous membrane formed by wet phase immersion method using PES (polyethersulfone). A theoretical equation for the description of the diffusion in the microfilter was derived and verified to be capable of predicting concentration distributions. Filtering capacity for molecules with various molecule sizes of this microfilter was evaluated using solution samples of sodium chloride (NaCl) and FITC (Fluorescein Isothiocyanate) Dextrans (MW 4k, 20k, 70k and 250k). This microfilter can be applied to artificial kidneys which can be implanted in human bodies.
我们提出了一种用于扩散分离溶质的新型微过滤器。该微过滤器由两个由聚醚砜(聚醚砜)制成的微室和一层湿相浸渍法形成的多孔膜组成。推导了描述微滤池内扩散的理论方程,并验证了其预测浓度分布的能力。使用氯化钠(NaCl)和FITC(异硫氰酸荧光素)右旋糖酐(MW 4k, 20k, 70k和250k)溶液样品评估该微过滤器对不同分子大小分子的过滤能力。该微过滤器可应用于人工肾脏,并可植入人体。
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引用次数: 4
Fabrication of SixNy Nanomechanical Structures Using Traditional Lithography and Gas Isotropic Etching 采用传统光刻技术和气体各向同性刻蚀技术制备六纳米结构
Bingqiao Liu, Zewen Liu, Fan Zhao, Litian Liu, Zhijian Li
We presented a novel idea for the fabrication of nanomechanical structures using a combination of traditional lithography technology and gas isotropic etching. The process starts from a 4" p-type silicon wafer, then two SixNy and SiO2 layers are alternatively deposited. After the patterning using traditional lithography with 2-mum resolution, SixNy pattern is obtained which is then used as the hard mask for gas isotropic etching, and a narrowed nanoscale SiO2 pattern is realized. The obtained structures can be further used to form nanochannel or nanoresonant devices. The SEM images show a nano-channel with triangle section and a suspended nanoscale SixNy mechanical structure. The minimum structure size is in the range of 100 nm.
我们提出了一种利用传统光刻技术和气体各向同性蚀刻相结合来制造纳米机械结构的新思路。该工艺从4英寸p型硅片开始,然后交替沉积两层SixNy和SiO2。采用传统的2微米分辨率光刻技术,得到SixNy图案,作为气体各向同性刻蚀的硬掩模,实现了窄化的纳米级SiO2图案。所获得的结构可以进一步用于形成纳米通道或纳米谐振器件。SEM图像显示出三角形截面的纳米通道和悬浮的纳米级SixNy机械结构。最小结构尺寸在100nm范围内。
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引用次数: 0
期刊
2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems
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