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Contemporary standpoint and future of 3D bioprinting in tissue/organs printing 3D生物打印在组织/器官打印中的当代观点和未来
IF 3.9 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100461
Vundrala Sumedha Reddy, Brindha Ramasubramanian, Vedant Mohan Telrandhe, Seeram Ramakrishna

Additive manufacturing, often known as three-dimensional (3D) printing, is driving significant progress in a diverse range of fields, such as engineering, manufacturing, food, and medicine. Realistic tissue models and organ transplantation can provide necessary innovative opportunities to tackle countless medical and health care obstacles. These can be achieved by incorporation of 3D printing into tissue engineering, using live cells encapsulated in natural or synthetic biomaterials. This evolution of 3D bioprinting has been the focus of our article. Here, we methodically discussed the current stance, history, techniques, materials, and taxonomy of 3D bioprinting along with the challenges encountered.

增材制造,通常被称为三维(3D)打印,正在推动工程、制造、食品和医药等各个领域的重大进步。现实的组织模型和器官移植可以提供必要的创新机会,以解决无数的医疗和卫生保健障碍。这些可以通过将3D打印结合到组织工程中来实现,使用包裹在天然或合成生物材料中的活细胞。3D生物打印的这种演变一直是我们文章的重点。在这里,我们系统地讨论了当前的立场,历史,技术,材料和生物3D打印的分类以及遇到的挑战。
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引用次数: 4
The myokinetic interface: Implanting permanent magnets to restore the sensory-motor control loop in amputees 肌动界面:植入永磁体以恢复截肢者的感觉运动控制回路
IF 3.9 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100460
Marta Gherardini , Federico Masiero , Valerio Ianniciello , Christian Cipriani

The development of a dexterous hand prosthesis that is controlled and perceived naturally by the amputee is a major challenge in biomedical engineering. Recent years have seen the rapid evolution of surgical techniques and technologies aimed at this purpose, the majority of which probe muscle electrical activity for control, and deliver electrical pulses to nerves for sensory feedback. Here, we report on the myokinetic interface concept that exploits magnetic field principles to achieve natural control and sensory feedback of an artificial hand. Like implantable myoelectric sensors, but using passive implants, localizing magnets implanted in independent muscles could allow monitoring their contractions and thus controlling the corresponding movements in the artificial hand in a biomimetic, direct, independent, and parallel manner. Selectively vibrating the magnets also offers a unique opportunity to study kinesthetic percepts in humans. The myokinetic interface opens new possibilities for interfacing humans with robotic technologies in an intuitive way.

开发一种能被截肢者自然控制和感知的灵巧手假肢是生物医学工程的一个主要挑战。近年来,针对这一目的的外科技术和技术迅速发展,其中大多数是探测肌肉电活动以进行控制,并向神经传递电脉冲以进行感觉反馈。在这里,我们报告了肌动力学界面的概念,利用磁场原理来实现人工手部的自然控制和感官反馈。像植入式肌电传感器一样,但使用被动植入物,植入独立肌肉的局部磁铁可以监测它们的收缩,从而以仿生的、直接的、独立的、平行的方式控制假手的相应运动。选择性地振动磁铁也为研究人类的动觉知觉提供了一个独特的机会。肌动力学界面以直观的方式为人类与机器人技术的交互开辟了新的可能性。
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引用次数: 0
Sustainable medical materials printed by melt electrowriting: A mini-review 熔融电解打印的可持续医疗材料:一个小回顾
IF 3.9 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100464
Huaizhong Xu , Lei Du

The development of melt electrowriting (MEW) technology can print many sustainable medical materials into high-resolution scaffolds to be applied in tissue engineering and regenerative medicine. The printability of the MEW can be highly improved after tuning and avoiding the particular phenomena of jet lag, fiber shifting, jet pulsing, and fiber bridging. Different MEW devices are developed to produce scaffolds with complicated or hierarchical structures to mimic human tissues. It is believed that the MEW technology can be extended to many other medical applications in the following years.

熔融电解技术的发展可以将许多可持续医用材料打印成高分辨率支架,应用于组织工程和再生医学。调整后的新材料可大大提高印刷性能,避免了时差、光纤移位、射流脉冲和光纤桥接等特殊现象。不同的MEW设备被开发用于制造具有复杂或分层结构的支架来模拟人体组织。相信在接下来的几年中,MEW技术可以扩展到许多其他医疗应用。
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引用次数: 0
Multiplexed CRISPR-based methods for pathogen nucleic acid detection 基于多重crispr的病原体核酸检测方法
IF 3.9 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100471
Caitlin H. Lamb, Brian Kang, Cameron Myhrvold

Bacterial and viral pathogens are devastating to human health and well-being. In many regions, dozens of pathogen species and variants co-circulate. Thus, it is important to detect many different species and variants of pathogens in a given sample through multiplexed detection methods. CRISPR-based nucleic acid detection has shown to be a promising step towards an easy-to-use, sensitive, specific, and high-throughput method to detect nucleic acids from DNA and RNA viruses and bacteria. Here, we review the current state of multiplexed nucleic acid detection methods with a focus on CRISPR-based methods. We also look toward the future of multiplexed point-of-care diagnostics.

细菌和病毒病原体对人类健康和福祉具有破坏性。在许多地区,数十种病原体和变异共同传播。因此,通过多路检测方法在给定样品中检测许多不同种类和病原体变体是很重要的。基于crispr的核酸检测已被证明是一种易于使用、敏感、特异性和高通量的方法,可以从DNA和RNA病毒和细菌中检测核酸。在这里,我们回顾了多路核酸检测方法的现状,重点介绍了基于crispr的方法。我们还展望了多路即时诊断的未来。
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引用次数: 1
Engineered intravenous therapies for trauma 为创伤设计静脉注射疗法
IF 3.9 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100456
Trey J. Pichon , Nathan J. White , Suzie H. Pun

Trauma leading to severe hemorrhage and shock on average kills patients within 3–6 h after injury. With average prehospital transport times reaching 1–6 h in low- to middle-income countries, stopping the bleeding and reversing hemorrhagic shock is vital. First-generation intravenous hemostats rely on traditional drug delivery platforms, such as self-assembling systems, fabricated nanoparticles, and soluble polymers due to their active targeting, biodistribution, and safety. We discuss some challenges in translating these therapies to patients, as very few have successfully made it through preclinical evaluation in large animals, and none have translated to the clinic. Finally, we discuss the physiology of hemorrhagic shock, highlight a new low-volume resuscitant (LVR) PEG-20k, and end with considerations for the rational design of LVRs.

创伤导致严重出血和休克,患者平均在受伤后3-6小时内死亡。中低收入国家的平均院前转运时间达到1-6小时,止血和逆转失血性休克至关重要。第一代静脉止血器依赖于传统的药物递送平台,如自组装系统、制造的纳米颗粒和可溶性聚合物,因为它们具有主动靶向性、生物分布性和安全性。我们讨论了将这些疗法转化为患者的一些挑战,因为很少有人成功通过大型动物的临床前评估,也没有人转化为临床。最后,我们讨论了失血性休克的生理学,重点介绍了一种新的低容量复苏剂(LVR)PEG-20k,并对LVR的合理设计进行了讨论。
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引用次数: 1
Biosignal-based co-adaptive user-machine interfaces for motor control 基于生物信号的电机控制协同自适应用户-机器界面
IF 3.9 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100462
Maneeshika M. Madduri , Samuel A. Burden , Amy L. Orsborn

User-machine interfaces map biological signals measured from the user to control commands for external devices. The mapping from biosignals to device inputs is performed by a decoding algorithm. Adaptation of both the user and decoder—co-adaptation—provides opportunities to improve the inclusivity and usability of interfaces for diverse users and applications. User learning leads to robust interface control that can generalize across environments and contexts. Decoder adaptation can personalize interfaces, account for day-to-day signal variability, and improve overall performance. Co-adaptation therefore creates opportunities to shape the user and decoder system to achieve robust and generalizable personalized interfaces. However, co-adaptation creates a two-learner system with dynamic interactions between the user and decoder. Engineering co-adaptive interfaces requires new tools and frameworks to analyze and design user-decoder interactions. In this article, we review adaptive decoding, user learning, and co-adaptation in user-machine interfaces, primarily brain-computer, myoelectric, and kinematic interfaces, for motor control. We then discuss performance criteria for co-adaptive interfaces and propose a game-theoretic approach to designing user-decoder co-adaptation.

用户-机器接口将从用户测量到的生物信号映射到外部设备的控制命令。从生物信号到设备输入的映射由解码算法执行。用户和解码器的适配(共同适配)为改进不同用户和应用程序界面的包容性和可用性提供了机会。用户学习导致健壮的界面控制,可以跨环境和上下文进行推广。解码器自适应可以个性化接口,考虑到日常信号的可变性,并提高整体性能。因此,共同适应创造了塑造用户和解码器系统的机会,以实现健壮和可通用的个性化界面。然而,共同适应创造了一个用户和解码器之间动态交互的双学习者系统。工程共适应接口需要新的工具和框架来分析和设计用户-解码器交互。在本文中,我们回顾了自适应解码,用户学习和共同适应在用户-机器接口,主要是脑-机,肌电和运动学接口,用于运动控制。然后,我们讨论了协同自适应接口的性能标准,并提出了一种设计用户-解码器协同自适应的博弈论方法。
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引用次数: 1
Intracellular antibodies and biodegraders: Beyond small molecules and back again 细胞内抗体和生物降解剂:超越小分子,再回来
IF 3.9 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100455
D. Cardella, D. Sanchez-Guzman, T.H. Rabbitts

Intracellular antibodies have been deployed as powerful research tools for the last 20 years for inhibition of proteins to convey specific information about protein function. Accordingly, intracellular antibodies have been used for target validation in oncology and were the first reagents to inhibit “undruggable” targets, such as RAS mutants and LMO2. Their versatility allows addition of effector functions to invoke cell phenotypes following target engagement inside cells. Moreover, the paratope–epitope interaction of intracellular antibodies has been recently exploited to develop small molecule surrogates. We will discuss the flexibility that intracellular antibodies provide for discovery research and for new generations of therapeutics in all clinical indications where an aberrant protein expression is involved (oncology, neurological disease, infection, inflammation).

在过去的20年里,细胞内抗体作为一种强大的研究工具被用于抑制蛋白质以传递蛋白质功能的特定信息。因此,细胞内抗体已被用于肿瘤学的靶标验证,并且是第一批抑制“不可药物”靶标的试剂,如RAS突变体和LMO2。它们的多功能性允许添加效应功能,以调用细胞内目标接合后的细胞表型。此外,细胞内抗体的旁位-表位相互作用最近被用于开发小分子替代品。我们将讨论细胞内抗体在涉及异常蛋白表达的所有临床适应症(肿瘤、神经系统疾病、感染、炎症)中为发现研究和新一代治疗提供的灵活性。
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引用次数: 0
Molecular dynamics simulation of membrane systems in the context of traumatic brain injury 创伤性脑损伤中膜系统的分子动力学模拟
IF 3.9 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-09-01 DOI: 10.1016/j.cobme.2023.100453
A.T.N. Vo , M.A. Murphy , P.K. Phan , T.W. Stone , R.K. Prabhu

Traumatic brain injury (TBI), caused by physical insults to the head, involves complex pathophysiological processes that damage the brain at multiple length scales. Unlike macroscale brain tissue damages, nanoscale cellular impairments, including neuron membrane integrity loss and mechanoporation, are elusive in experiments and necessitate the implementation of in silico atomic-level approaches, such as molecular dynamics (MD) simulations. MD studies have rapidly developed over the past decades, significantly enhancing our understanding in membrane dynamics and biomechanically plausible damage mechanisms induced by TBI. Hence, in this article, we will give an overview of recent MD membrane system models in the context of TBI and discuss the ongoing advancements as well as challenges in this research area.

创伤性脑损伤(TBI)是由头部的物理损伤引起的,涉及复杂的病理生理过程,可在多个长度尺度上损伤大脑。与宏观尺度的脑组织损伤不同,纳米尺度的细胞损伤,包括神经元膜完整性丧失和机械变形,在实验中是难以捉摸的,需要在硅原子水平的方法中实现,如分子动力学(MD)模拟。在过去的几十年里,MD研究迅速发展,极大地提高了我们对膜动力学和生物力学损伤机制的理解。因此,在本文中,我们将概述最近在脑外伤背景下的MD膜系统模型,并讨论该研究领域的进展和挑战。
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引用次数: 1
Toward the use of muscle reinnveration for chronic bidirectional control of prostheses to improve functional outcomes of end users 在慢性假体双向控制中使用肌肉修复来改善最终使用者的功能结果
IF 3.9 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-08-26 DOI: 10.1016/j.cobme.2023.100497
Deanna H. Gates , Michael A. Gonzalez , Theodore A. Kung , Cynthia A. Chestek

Regenerative peripheral nerve interfaces (RPNI) and targeted muscle reinnervation (TMR) are surgical approaches for redirecting peripheral nerve growth to denervated muscle targets after amputation. These approaches have demonstrated promise at reducing post-amputation pain and are now frequently performed at the time of amputation. Both TMR and RPNI can also serve as bioamplifiers for efferent neural signals that once went to the lost limb. Through reinnervation of muscle and skin, patients may also afford meaningful afferent feedback. Accordingly, these surgical approaches can be beneficial for bidirectional prostheses. This review discusses recent literature on management of post-amputation pain, prosthetic control, and sensory feedback with each approach. We also discuss how these approaches can be incorporated into wearable systems to improve function in daily life.

再生周围神经界面(RPNI)和靶向肌肉神经再生(TMR)是截肢后将周围神经生长重定向到失神经肌肉目标的手术方法。这些方法在减少截肢后疼痛方面已经被证明是有希望的,现在经常在截肢时进行。TMR和RPNI都可以作为生物放大器,接收曾经到达失肢的传出神经信号。通过肌肉和皮肤的神经再支配,患者也可以提供有意义的传入反馈。因此,这些手术入路对双向假体是有益的。这篇综述讨论了最近关于截肢后疼痛管理、假肢控制和每种入路的感觉反馈的文献。我们还讨论了如何将这些方法纳入可穿戴系统以改善日常生活中的功能。
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引用次数: 1
Optical imaging technologies for in vivo cancer detection in low-resource settings 低资源环境下癌症体内检测的光学成像技术
IF 3.9 3区 工程技术 Q2 ENGINEERING, BIOMEDICAL Pub Date : 2023-08-23 DOI: 10.1016/j.cobme.2023.100495
Huayu Hou , Ruchika Mitbander , Yubo Tang , Ahad Azimuddin , Jennifer Carns , Richard A. Schwarz , Rebecca R. Richards-Kortum

Cancer continues to affect underserved populations disproportionately. Novel optical imaging technologies, which can provide rapid, non-invasive, and accurate cancer detection at the point of care, have great potential to improve global cancer care. This article reviews the recent technical innovations and clinical translation of low-cost optical imaging technologies, highlighting the advances in both hardware and software, especially the integration of artificial intelligence, to improve in vivo cancer detection in low-resource settings. Additionally, this article provides an overview of existing challenges and future perspectives of adapting optical imaging technologies into clinical practice, which can potentially contribute to novel insights and programs that effectively improve cancer detection in low-resource settings.

癌症继续不成比例地影响服务不足的人群。新型光学成像技术可以在护理点提供快速、无创和准确的癌症检测,具有改善全球癌症护理的巨大潜力。本文综述了近年来低成本光学成像技术的技术创新和临床应用,重点介绍了硬件和软件方面的进步,特别是人工智能的整合,以提高低资源环境下的体内癌症检测。此外,本文还概述了将光学成像技术应用于临床实践的现有挑战和未来前景,这可能有助于在低资源环境下有效提高癌症检测的新见解和新项目。
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引用次数: 0
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Current Opinion in Biomedical Engineering
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