Pub Date : 2024-09-01DOI: 10.1016/j.mattod.2024.06.009
The industry has always strived to design “hard” and “crack-resistant” glass. However, simultaneously realizing these properties in oxide glasses has been rare. Although Al2O3-rich hard and crack-resistant oxide glasses have been reported in the last decade, they exhibit two significant technological challenges that hinder their translation from laboratory to industry: (1) high processing temperatures (>2000 °C) and (2) small glass-forming regions (near eutectic). The present study reports the structural design of a hard and high modulus glass with high crack initiation resistance designed in the peraluminous region of rare-earth containing MgO–Al2O3–B2O3–SiO2 system. The glass can be processed at a temperature ≤1650 °C and exhibits Vickers hardness (Hv) of 7.84 GPa (at 1.96 N load) and indentation crack resistance (ICR) of 26.5 N. These Hv and ICR values are significantly higher than most commercial or non-commercial glasses (prior to thermal tempering, densification near Tg, or chemical strengthening). The glass has been scaled up to successfully produce slabs of dimensions 100 mm × 100 mm × 8 mm at laboratory scale with optical transmission of 90 ± 2 %. The results presented here are scientifically intriguing and have considerable tangible implications, as they pave the path for the design and development of stronger glasses for functional applications.
业界一直致力于设计 "坚硬 "和 "抗裂 "的玻璃。然而,在氧化物玻璃中同时实现这些特性的情况却很少见。虽然在过去十年中已有富含 Al2O3 的硬质抗裂氧化物玻璃的报道,但它们在技术上面临着两个重大挑战,阻碍了它们从实验室到工业领域的转化:(1)加工温度高(2000 °C);(2)玻璃形成区域小(接近共晶)。本研究报告介绍了在含稀土的 MgO-Al2O3-B2O3-SiO2 体系过铝区设计的一种高硬度、高模量、高抗裂性玻璃的结构设计。该玻璃的加工温度≤1650 °C,维氏硬度(Hv)为 7.84 GPa(载荷为 1.96 N 时),抗压痕开裂性能(ICR)为 26.5 N。这些 Hv 值和 ICR 值明显高于大多数商用或非商业玻璃(在热回火、接近 Tg 时的致密化或化学强化之前)。这种玻璃已在实验室规模上成功生产出尺寸为 100 mm × 100 mm × 8 mm 的板坯,其光学透射率为 90 ± 2 %。本文介绍的结果具有科学意义和相当大的实际影响,因为它们为设计和开发更强的功能性应用玻璃铺平了道路。
{"title":"Structural design of a scalable glass with high hardness and crack initiation resistance","authors":"","doi":"10.1016/j.mattod.2024.06.009","DOIUrl":"10.1016/j.mattod.2024.06.009","url":null,"abstract":"<div><p>The industry has always strived to design “hard” and “crack-resistant” glass. However, simultaneously realizing these properties in oxide glasses has been rare. Although Al<sub>2</sub>O<sub>3</sub>-rich hard and crack-resistant oxide glasses have been reported in the last decade, they exhibit two significant technological challenges that hinder their translation from laboratory to industry: (1) high processing temperatures (>2000 °C) and (2) small glass-forming regions (near eutectic). The present study reports the structural design of a hard and high modulus glass with high crack initiation resistance designed in the peraluminous region of rare-earth containing MgO–Al<sub>2</sub>O<sub>3</sub>–B<sub>2</sub>O<sub>3</sub>–SiO<sub>2</sub> system. The glass can be processed at a temperature ≤1650 °C and exhibits Vickers hardness (H<sub>v</sub>) of 7.84 GPa (at 1.96 N load) and indentation crack resistance (ICR) of 26.5 N. These H<sub>v</sub> and ICR values are significantly higher than most commercial or non-commercial glasses (prior to thermal tempering, densification near T<sub>g</sub>, or chemical strengthening). The glass has been scaled up to successfully produce slabs of dimensions 100 mm × 100 mm × 8 mm at laboratory scale with optical transmission of 90 ± 2 %. The results presented here are scientifically intriguing and have considerable tangible implications, as they pave the path for the design and development of stronger glasses for functional applications.</p></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":null,"pages":null},"PeriodicalIF":21.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1369702124001111/pdfft?md5=8377ed4dbbf72d120143e175c9c6e10a&pid=1-s2.0-S1369702124001111-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141703377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.mattod.2024.06.017
Metal-organic frameworks (MOFs)-engineered reactive-oxygen catalytic materials (ROCMs) have offered essential contributions to boosting the biocatalytic efficiency in diverse biomedical applications. While since the varied coordination environments, abundant node-ligand pairs, and multiple or complex atom sites, precisely overviewing the mechanisms and revealing the structure–reactivity relationships of MOFs-engineered ROCMs still confront great challenges, which is essential to direct the future design and applications of ROCMs. Here, we provide a comprehensive summarization of the latest progress and future trends in MOFs-engineered ROCMs with enzyme-mimicking structures for ROS regulation and biotherapeutic applications. First, the catalytic behaviors and fundamental mechanisms of MOFs-engineered ROCMs on regulating ROS levels are outlined. Then, the enzyme-mimicking coordination environments and structure evolutions of MOFs-engineered ROCMs are discussed thoroughly, including coordination modulation, hybrid structures, carbon nanostructures, and single-atom materials. Particularly, we offer unique insights into enzyme structure mimicking, microenvironment modulation, structure evolutions, and theoretical understanding for revealing mechanisms. Thereafter, the representative biotherapeutic applications have been summarized with a unique focus on structural property-reactivity relationships. Finally, we systematically highlight the current challenges and future perspectives. Overall, this is a timely review that focuses on creating MOF structures for reactive-oxygen biocatalysis from structure-activity relationships to biological properties. We envision this cutting review will substantially stimulate the development and widespread utilization of MOFs-engineered ROCMs in biomedical applications.
{"title":"Metal-organic frameworks-engineered reactive-oxygen catalytic materials: Enzyme-mimicking coordinations, structure evolutions, and biotherapeutic applications","authors":"","doi":"10.1016/j.mattod.2024.06.017","DOIUrl":"10.1016/j.mattod.2024.06.017","url":null,"abstract":"<div><p><span><span>Metal-organic frameworks (MOFs)-engineered reactive-oxygen catalytic materials (ROCMs) have offered essential contributions to boosting the biocatalytic efficiency in diverse biomedical applications. While since the varied coordination environments, abundant node-ligand pairs, and multiple or complex atom sites, precisely overviewing the mechanisms and revealing the structure–reactivity relationships of MOFs-engineered ROCMs still confront great challenges, which is essential to direct the future design and applications of ROCMs. Here, we provide a comprehensive summarization of the latest progress and future trends in MOFs-engineered ROCMs with enzyme-mimicking structures for ROS regulation and biotherapeutic applications. First, the catalytic behaviors and fundamental mechanisms of MOFs-engineered ROCMs on regulating ROS levels are outlined. Then, the enzyme-mimicking coordination environments and structure evolutions of MOFs-engineered ROCMs are discussed thoroughly, including coordination modulation, hybrid structures, </span>carbon nanostructures, and single-atom materials. Particularly, we offer unique insights into </span>enzyme<span> structure mimicking, microenvironment modulation, structure evolutions, and theoretical understanding for revealing mechanisms. Thereafter, the representative biotherapeutic applications have been summarized with a unique focus on structural property-reactivity relationships. Finally, we systematically highlight the current challenges and future perspectives. Overall, this is a timely review that focuses on creating MOF structures for reactive-oxygen biocatalysis from structure-activity relationships to biological properties. We envision this cutting review will substantially stimulate the development and widespread utilization of MOFs-engineered ROCMs in biomedical applications.</span></p></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":null,"pages":null},"PeriodicalIF":21.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.mattod.2024.06.011
Two-dimensional (2D) transition metal carbides/nitrides, MXenes (in particular Ti3C2Tx), and three-dimensional (3D) structures such as polymeric hydrogels or aerogels, are promising families of materials, each in their own right, with advantageous properties for applications in biomedicine, water treatment, electronic devices, and energy. Combination of MXenes with hydro- or aerogels may further improve their individual properties and impart new characteristics. Potentially, it can also significantly improve the chemical stability of MXenes, which is currently one of the main limiting factors for their widespread use. In this paper, we review some representative fabrication techniques and properties of Ti3C2Tx MXene/3D hydrogel and aerogel composites, as well as selected applications of these composites for energy storage and harvesting, biology and medicine, water treatment, and EMI shielding.
{"title":"MXene filled hydrogel and aerogel composites","authors":"","doi":"10.1016/j.mattod.2024.06.011","DOIUrl":"10.1016/j.mattod.2024.06.011","url":null,"abstract":"<div><p>Two-dimensional (2D) transition metal carbides/nitrides, MXenes (in particular Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub><span>), and three-dimensional (3D) structures such as polymeric hydrogels or aerogels<span>, are promising families of materials, each in their own right, with advantageous properties for applications in biomedicine, water treatment, electronic devices, and energy. Combination of MXenes with hydro- or aerogels may further improve their individual properties and impart new characteristics. Potentially, it can also significantly improve the chemical stability of MXenes, which is currently one of the main limiting factors for their widespread use. In this paper, we review some representative fabrication techniques and properties of Ti</span></span><sub>3</sub>C<sub>2</sub>T<sub>x</sub><span> MXene/3D hydrogel and aerogel composites, as well as selected applications of these composites for energy storage and harvesting, biology and medicine, water treatment, and EMI shielding.</span></p></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":null,"pages":null},"PeriodicalIF":21.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-01DOI: 10.1016/j.mattod.2024.07.001
Defective carbon materials have emerged as promising candidates for the electrocatalysis of oxygen reduction reaction (ORR) to selectively produce H2O2. However, distinguishing the roles of oxygenates and carbon defects in carbon for 2e- ORR remains to be challenging. In a recent issue of Nature Communications, Yao and coworkers pinpointed the major active sites in oxygenated carbon materials and identified the key intermediate employing a series of dynamic and simulation techniques. In addition to highlight the proposed work, this comment article also discussed pioneering methodologies to characterize structure dynamics and probe the integral active center for rational design of carbon based catalysts with atomic precision.
{"title":"Pinpointing carbonyl on pentagon defect for H2O2 electrosynthesis","authors":"","doi":"10.1016/j.mattod.2024.07.001","DOIUrl":"10.1016/j.mattod.2024.07.001","url":null,"abstract":"<div><p>Defective carbon materials have emerged as promising candidates for the electrocatalysis of oxygen reduction reaction (ORR) to selectively produce H<sub>2</sub>O<sub>2</sub>. However, distinguishing the roles of oxygenates and carbon defects in carbon for 2e- ORR remains to be challenging. In a recent issue of Nature Communications, Yao and coworkers pinpointed the major active sites in oxygenated carbon materials and identified the key intermediate employing a series of dynamic and simulation techniques. In addition to highlight the proposed work, this comment article also discussed pioneering methodologies to characterize structure dynamics and probe the integral active center for rational design of carbon based catalysts with atomic precision.</p></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":null,"pages":null},"PeriodicalIF":21.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141853538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-28DOI: 10.1016/j.mattod.2024.07.015
Spinal cord injury (SCI) is a devastating neurotrauma, affecting 250,000 to 500,000 people annually, and typically results in paralysis. Electrostimulation can promote neuronal growth, but the formation of a lesion cavity post-SCI inhibits regrowth, limiting its efficacy. Bridging the lesion with a structured, electroactive substrate to direct electrostimulation to growing neurites could support and drive neuronal regrowth through the lesion to enable functional recovery but to date, no such platform exists. This study describes the development of an electroconductive (15 ± 5 S/m), 3D-printed scaffold, comprising a polypyrrole/polycaprolactone framework filled with biomimetic & neurotrophic extracellular matrix. 3D printing allowed inclusion of channels in the scaffold designed to mimic the size of human corticospinal tracts to direct electrostimulation to growing neurons. Scaffolds exhibited excellent biocompatibility with both neurons and human primary astrocytes and maintained electrical and biofunctionality when scaled to match the size of human corticospinal tracts. When neurons were cultured for 7 days on the scaffolds under continuous electrostimulation (200 mV/mm, 12 Hz), significantly longer neurites were observed on electrically stimulated electroconductive scaffolds. These results demonstrate that electrostimulation applied via an anatomically-mimetic, 3D-printed electroconductive scaffold drives neurite outgrowth and represents a promising approach for treatment of spinal cord injury.
{"title":"Electrostimulation via a 3D-printed, biomimetic, neurotrophic, electroconductive scaffold for the promotion of axonal regrowth after spinal cord injury","authors":"","doi":"10.1016/j.mattod.2024.07.015","DOIUrl":"10.1016/j.mattod.2024.07.015","url":null,"abstract":"<div><p>Spinal cord injury (SCI) is a devastating neurotrauma, affecting 250,000 to 500,000 people annually, and typically results in paralysis. Electrostimulation can promote neuronal growth, but the formation of a lesion cavity post-SCI inhibits regrowth, limiting its efficacy. Bridging the lesion with a structured, electroactive substrate to direct electrostimulation to growing neurites could support and drive neuronal regrowth through the lesion to enable functional recovery but to date, no such platform exists. This study describes the development of an electroconductive (15 ± 5 S/m), 3D-printed scaffold, comprising a polypyrrole/polycaprolactone framework filled with biomimetic & neurotrophic extracellular matrix. 3D printing allowed inclusion of channels in the scaffold designed to mimic the size of human corticospinal tracts to direct electrostimulation to growing neurons. Scaffolds exhibited excellent biocompatibility with both neurons and human primary astrocytes and maintained electrical and biofunctionality when scaled to match the size of human corticospinal tracts. When neurons were cultured for 7 days on the scaffolds under continuous electrostimulation (200 mV/mm, 12 Hz), significantly longer neurites were observed on electrically stimulated electroconductive scaffolds. These results demonstrate that electrostimulation applied via an anatomically-mimetic, 3D-printed electroconductive scaffold drives neurite outgrowth and represents a promising approach for treatment of spinal cord injury.</p></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":null,"pages":null},"PeriodicalIF":21.1,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S136970212400155X/pdfft?md5=b949bf3a37a6c5e476c606c0f71e29aa&pid=1-s2.0-S136970212400155X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-27DOI: 10.1016/j.mattod.2024.08.002
The tungsten with high oxidation states (W6+) had been proved to effectively improve the electrochemical performance of ultrahigh-nickel (Ni ≥ 90 %) cathode materials due to the unique microstructures. However, the exat location and underlying action mechanism of tungsten are still not well-understood, and there have been no reports on in-situ modification from bulk to surface simultaneously for these novel cathode materials. Here, a novel integrated strategy is proposed for in-situ modification of LiNi0.9Co0.09W0.01O2 (NCW). Innovatively, the introduction of nano spinel phase and titanium pinned into the lattice further suppresses the anisotropic variation of unit cell and promotes the lithium-ion migration kinetics within the bulk. Additionally, the Li2TiO3 conductive network enhances migration kinetics across interface and protects the active material against electrolyte erosion. Furthermore, the combination of in-situ analysis and DFT calculation reveals the ordered distribution of tungsten and the suppression effects of titanium on phase transition and cobalt redox. Consequently, the titanium-modified NCW exhibits significantly improved electrochemical performance, such as capacity retention of 93.0 % at 1C after 500 cycles in pouch-type full-cell, along with stable lattice oxygen during operation.
{"title":"Constructing nano spinel phase and Li+ conductive network to enhance the electrochemical stability of ultrahigh-Ni cathode","authors":"","doi":"10.1016/j.mattod.2024.08.002","DOIUrl":"10.1016/j.mattod.2024.08.002","url":null,"abstract":"<div><p>The tungsten with high oxidation states (W<sup>6+</sup>) had been proved to effectively improve the electrochemical performance of ultrahigh-nickel (Ni ≥ 90 %) cathode materials due to the unique microstructures. However, the exat location and underlying action mechanism of tungsten are still not well-understood, and there have been no reports on in-situ modification from bulk to surface simultaneously for these novel cathode materials. Here, a novel integrated strategy is proposed for in-situ modification of LiNi<sub>0.9</sub>Co<sub>0.09</sub>W<sub>0.01</sub>O<sub>2</sub> (NCW). Innovatively, the introduction of nano spinel phase and titanium pinned into the lattice further suppresses the anisotropic variation of unit cell and promotes the lithium-ion migration kinetics within the bulk. Additionally, the Li<sub>2</sub>TiO<sub>3</sub> conductive network enhances migration kinetics across interface and protects the active material against electrolyte erosion. Furthermore, the combination of in-situ analysis and DFT calculation reveals the ordered distribution of tungsten and the suppression effects of titanium on phase transition and cobalt redox. Consequently, the titanium-modified NCW exhibits significantly improved electrochemical performance, such as capacity retention of 93.0 % at 1C after 500 cycles in pouch-type full-cell, along with stable lattice oxygen during operation.</p></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":null,"pages":null},"PeriodicalIF":21.1,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-24DOI: 10.1016/j.mattod.2024.08.001
In the domain of smart robotics, the refinement of tactile imaging constitutes a seminal element for enhancement of human–machine interaction (HMI) and enrichment of artificial intelligence (AI). This field is confronted with dual challenges of achieving high-sensitive pressure detection and precise localization of tactile stimuli. In response, the current research introduces a groundbreaking self-powered bimodal tactile imaging device (TID), featuring a configuration of high-dielectric thin film superimposed on laser-induced graphene (LIG) electrodes. This pioneering design is conceived to facilitate not only the detection of subtle pressure but also to support real-time visual recognition and intelligent control functionalities. The bimodal nature of the TID allows for the transformation of slight tactile inputs into both luminous triboelectrification-induced electroluminescence (TIEL) and measurable electrical signals, thereby seamlessly merging the realms of tactile perception and optical display. Leveraging the luminosity of TIEL, the TID adeptly achieves tactile imaging and immediate visual recognition, with its capabilities further enhanced through the integration of machine learning algorithms. Additionally, the TID exhibits a remarkable proficiency in precise tactile localization, through the analysis of voltage outputs initiated by delicate touching and sliding motions. Moreover, an advanced intelligent control system, predicated on the optical-electrical dual-modal sensing provided by the TID, has been developed. This system illustrates the synergistic fusion of visual recognition with accurate tactile localization, underscoring the substantial utility of the bimodal TID across diverse applications in HMI, AI, and intelligent robotic platforms and heralding new avenues for interactive and responsive robotic systems.
在智能机器人领域,触觉成像的改进是增强人机交互(HMI)和丰富人工智能(AI)的重要因素。该领域面临着实现高灵敏度压力检测和触觉刺激精确定位的双重挑战。为此,目前的研究引入了一种开创性的自供电双模触觉成像设备(TID),其特点是在激光诱导石墨烯(LIG)电极上叠加高介电薄膜配置。这种开创性的设计不仅有助于检测微妙的压力,还能支持实时视觉识别和智能控制功能。TID 的双模特性可将轻微的触觉输入转化为发光的三电致发光(TIEL)和可测量的电信号,从而将触觉感知和光学显示领域完美地融合在一起。利用 TIEL 的亮度,TID 能够巧妙地实现触觉成像和即时视觉识别,并通过整合机器学习算法进一步增强其功能。此外,通过分析由细微触摸和滑动动作引发的电压输出,TID 在精确触觉定位方面表现出了非凡的能力。此外,基于 TID 提供的光电双模传感,还开发出了一种先进的智能控制系统。该系统展示了视觉识别与精确触觉定位的协同融合,强调了双模 TID 在人机界面、人工智能和智能机器人平台等不同应用领域的巨大作用,并预示着交互式响应机器人系统的新途径。
{"title":"Self-powered bimodal tactile imaging device for ultrasensitive pressure sensing, real-time visualization recognition, and intelligent control","authors":"","doi":"10.1016/j.mattod.2024.08.001","DOIUrl":"10.1016/j.mattod.2024.08.001","url":null,"abstract":"<div><p>In the domain of smart robotics, the refinement of tactile imaging constitutes a seminal element for enhancement of human–machine interaction (HMI) and enrichment of artificial intelligence (AI). This field is confronted with dual challenges of achieving high-sensitive pressure detection and precise localization of tactile stimuli. In response, the current research introduces a groundbreaking self-powered bimodal tactile imaging device (TID), featuring a configuration of high-dielectric thin film superimposed on laser-induced graphene (LIG) electrodes. This pioneering design is conceived to facilitate not only the detection of subtle pressure but also to support real-time visual recognition and intelligent control functionalities. The bimodal nature of the TID allows for the transformation of slight tactile inputs into both luminous triboelectrification-induced electroluminescence (TIEL) and measurable electrical signals, thereby seamlessly merging the realms of tactile perception and optical display. Leveraging the luminosity of TIEL, the TID adeptly achieves tactile imaging and immediate visual recognition, with its capabilities further enhanced through the integration of machine learning algorithms. Additionally, the TID exhibits a remarkable proficiency in precise tactile localization, through the analysis of voltage outputs initiated by delicate touching and sliding motions. Moreover, an advanced intelligent control system, predicated on the optical-electrical dual-modal sensing provided by the TID, has been developed. This system illustrates the synergistic fusion of visual recognition with accurate tactile localization, underscoring the substantial utility of the bimodal TID across diverse applications in HMI, AI, and intelligent robotic platforms and heralding new avenues for interactive and responsive robotic systems.</p></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":null,"pages":null},"PeriodicalIF":21.1,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-16DOI: 10.1016/j.mattod.2024.07.013
Zifan Pei, Nan Jiang, Fei Gong, Weihao Yang, Jiachen Xu, Bin Yu, Nailin Yang, Jie Wu, Huali Lei, Shumin Sun, Longxiao Li, Zhicheng Liu, Caifang Ni, Liang Cheng
Growing evidence has demonstrated the positive role of bioactive metal ions in enhancing pyroptosis-mediated cancer immunotherapy. However, further amplification of the sustained immune response remains challenging. Herein, by selecting from typical metal anions, we confirmed the significant cytotoxicity and pyroptosis induction potency of vanadate anions, owing to the inhibition of ATPases and disruption of intracellular ion homeostasis. Then, PEGylated bimetallic manganese vanadate nanoparticles (MnVO) were synthesized for stimulator of interferon genes (STING) pathway-boosted pyroptosis therapy. The vanadate produced from MnVO degradation inhibited membrane ATPases and induced potassium efflux and calcium overload, resulting in inflammasome activation, mitochondrial damage, and endoplasmic reticulum stress, as well as subsequent robust pyroptotic cell death. The released manganese ions stimulated STING pathway through dendritic cells maturation and type I interferon secretion. This dual strategy triggered strong anti-tumor immunity and promoted immune cell infiltration into the tumor, which further defeated distant tumors in combination with immune checkpoint blockade (ICB) therapy. Moreover, by dispersing MnVO with lipiodol for interventional transarterial embolization (TAE) therapy, an enhanced therapeutic efficacy was achieved in orthotopic rabbit liver cancer compared to that of lipiodol alone. Our work highlights the biological effect of metal anions in inducing pyroptosis, as well as the synergistic immunotherapy involving pyroptosis induction and STING activation.
越来越多的证据表明,生物活性金属离子在增强热蛋白沉积介导的癌症免疫疗法方面发挥着积极作用。然而,进一步扩大持续免疫反应仍具有挑战性。在本文中,我们从典型的金属阴离子中筛选出了钒酸阴离子,证实了钒酸阴离子由于抑制 ATP 酶和破坏细胞内离子平衡而具有显著的细胞毒性和诱导发热作用。然后,合成了 PEG 化双金属钒酸锰纳米粒子(MnVO),用于干扰素基因刺激器(STING)通路的热毒症治疗。MnVO 降解产生的钒酸盐抑制膜 ATP 酶,诱导钾离子外流和钙离子超载,导致炎症小体激活、线粒体损伤和内质网应激,以及随后细胞的强热休克死亡。释放的锰离子通过树突状细胞成熟和 I 型干扰素分泌刺激 STING 通路。这种双重策略引发了强大的抗肿瘤免疫力,并促进了免疫细胞向肿瘤的浸润,与免疫检查点阻断疗法(ICB)相结合,进一步战胜了远处的肿瘤。此外,通过将 MnVO 与脂碘醇一起分散用于介入性经动脉栓塞(TAE)治疗,与单独使用脂碘醇相比,在正位兔肝癌中取得了更好的疗效。我们的研究工作凸显了金属阴离子在诱导化脓过程中的生物效应,以及化脓诱导和 STING 激活的协同免疫疗法。
{"title":"A metal anion strategy to induce pyroptosis combined with STING activation to synergistically amplify anti-tumor immunity","authors":"Zifan Pei, Nan Jiang, Fei Gong, Weihao Yang, Jiachen Xu, Bin Yu, Nailin Yang, Jie Wu, Huali Lei, Shumin Sun, Longxiao Li, Zhicheng Liu, Caifang Ni, Liang Cheng","doi":"10.1016/j.mattod.2024.07.013","DOIUrl":"https://doi.org/10.1016/j.mattod.2024.07.013","url":null,"abstract":"Growing evidence has demonstrated the positive role of bioactive metal ions in enhancing pyroptosis-mediated cancer immunotherapy. However, further amplification of the sustained immune response remains challenging. Herein, by selecting from typical metal anions, we confirmed the significant cytotoxicity and pyroptosis induction potency of vanadate anions, owing to the inhibition of ATPases and disruption of intracellular ion homeostasis. Then, PEGylated bimetallic manganese vanadate nanoparticles (MnVO) were synthesized for stimulator of interferon genes (STING) pathway-boosted pyroptosis therapy. The vanadate produced from MnVO degradation inhibited membrane ATPases and induced potassium efflux and calcium overload, resulting in inflammasome activation, mitochondrial damage, and endoplasmic reticulum stress, as well as subsequent robust pyroptotic cell death. The released manganese ions stimulated STING pathway through dendritic cells maturation and type I interferon secretion. This dual strategy triggered strong anti-tumor immunity and promoted immune cell infiltration into the tumor, which further defeated distant tumors in combination with immune checkpoint blockade (ICB) therapy. Moreover, by dispersing MnVO with lipiodol for interventional transarterial embolization (TAE) therapy, an enhanced therapeutic efficacy was achieved in orthotopic rabbit liver cancer compared to that of lipiodol alone. Our work highlights the biological effect of metal anions in inducing pyroptosis, as well as the synergistic immunotherapy involving pyroptosis induction and STING activation.","PeriodicalId":387,"journal":{"name":"Materials Today","volume":null,"pages":null},"PeriodicalIF":24.2,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142180334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-15DOI: 10.1016/j.mattod.2024.07.011
The creation of three dimensional (3D) structures out of two-dimensional (2D) materials while retaining their extraordinary mechanical and transport properties after processing is one of the current great challenges in materials sciences (Ruoff, 2008; Kong et al., 2019; Lin et al., 2019). Guided by density functional theory (DFT) and molecular dynamics (MD) simulations we found a successful route for a sustainable production of 3D metallic carbon materials that are synthesized from pristine 2D graphene flakes with hydrolyzed edges. The edge hydrolysis lead to strong geometrical anisotropy and self-organization in solution before processing. After processing we obtain a 3D carbon structure where 2D graphene flakes are crosslinked by carbon chains with aromatic groups at very mild annealing temperatures (∼150 °C), eliminating the constraints for achieving the in-situ preparation of conductive carbon structures. These 3D carbon structures preserve microscopic order but are macroscopically disordered, presenting physical properties of anisotropic metallic carbon with large Young modulus (E ≈ 20 GPa), and room temperature thermal (k ≈ 180 W/mK) and electrical (σ ≈ 300 kS/m) conductivities comparable to ordinary metals.
{"title":"Disordered metallic carbon materials from graphene edge chemistry","authors":"","doi":"10.1016/j.mattod.2024.07.011","DOIUrl":"10.1016/j.mattod.2024.07.011","url":null,"abstract":"<div><p>The creation of three dimensional (3D) structures out of two-dimensional (2D) materials while retaining their extraordinary mechanical and transport properties after processing is one of the current great challenges in materials sciences (Ruoff, 2008; Kong et al., 2019; Lin et al., 2019). Guided by density functional theory (DFT) and molecular dynamics (MD) simulations we found a successful route for a sustainable production of 3D metallic carbon materials that are synthesized from pristine 2D graphene flakes with hydrolyzed edges. The edge hydrolysis lead to strong geometrical anisotropy and self-organization in solution before processing. After processing we obtain a 3D carbon structure where 2D graphene flakes are crosslinked by carbon chains with aromatic groups at very mild annealing temperatures (∼150 °C), eliminating the constraints for achieving the in-situ preparation of conductive carbon structures. These 3D carbon structures preserve microscopic order but are macroscopically disordered, presenting physical properties of anisotropic metallic carbon with large Young modulus (E ≈ 20 GPa), and room temperature thermal (k ≈ 180 W/mK) and electrical (σ ≈ 300 kS/m) conductivities comparable to ordinary metals.</p></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":null,"pages":null},"PeriodicalIF":21.1,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-12DOI: 10.1016/j.mattod.2024.07.009
Body-centred cubic (BCC) transition metals tend to be brittle at low temperatures, which poses significant challenges in their processing and major concerns for damage tolerance. The brittleness is largely dictated by cleavage fracture at crack-tips and high lattice frictions of screw dislocation cores; the nature and control of which remain a puzzle after nearly a century. Here, we introduce a crystal geometry-based, semi-empirical material index χ, the energy difference between the BCC and face-centred-cubic structures, that guides engineering of crack-tip and screw dislocation core properties. The unstable stacking fault energy on planes and screw dislocation Peierls barrier have near-linear scaling with χ and the screw core transforms from non-degenerate to degenerate when χ drops below some thresholds in homogenized BCC alloys, as demonstrated in binary transition metal alloys. The index χ has its origin in crystal geometry and can be extended to finite temperatures; its value is related to entropy and valence electron concentrations, which can be quantitatively predicted by first-principles calculations and effectively tuned in solid solution alloys. The χ-model and computational approach provide a practical path to screening of favourable solutes and compositions for enhanced ductility and toughness in BCC alloys.
{"title":"The taming of the screw: Dislocation cores in BCC metals and alloys","authors":"","doi":"10.1016/j.mattod.2024.07.009","DOIUrl":"10.1016/j.mattod.2024.07.009","url":null,"abstract":"<div><p>Body-centred cubic (BCC) transition metals tend to be brittle at low temperatures, which poses significant challenges in their processing and major concerns for damage tolerance. The brittleness is largely dictated by cleavage fracture at crack-tips and high lattice frictions of screw dislocation cores; the nature and control of which remain a puzzle after nearly a century. Here, we introduce a crystal geometry-based, semi-empirical material index χ, the energy difference between the BCC and face-centred-cubic structures, that guides engineering of crack-tip and screw dislocation core properties. The unstable stacking fault energy on <span><math><mrow><mfenced><mrow><mn>1</mn><mspace></mspace><mn>1</mn><mspace></mspace><mn>0</mn></mrow></mfenced></mrow></math></span> planes and screw dislocation Peierls barrier have near-linear scaling with χ and the screw core transforms from non-degenerate to degenerate when χ drops below some thresholds in homogenized BCC alloys, as demonstrated in binary transition metal alloys. The index χ has its origin in crystal geometry and can be extended to finite temperatures; its value is related to entropy and valence electron concentrations, which can be quantitatively predicted by first-principles calculations and effectively tuned in solid solution alloys. The χ-model and computational approach provide a practical path to screening of favourable solutes and compositions for enhanced ductility and toughness in BCC alloys.</p></div>","PeriodicalId":387,"journal":{"name":"Materials Today","volume":null,"pages":null},"PeriodicalIF":21.1,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142180335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}