Microchemical Journal最新文献_第9页

On-line preconcentration techniques for hydrophobic compounds in capillary electrokinetic chromatography: A review 毛细管电动色谱法中疏水化合物的在线预浓缩技术：综述

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-19 DOI: 10.1016/j.microc.2024.111693

Capillary electrophoresis (CE) is a competitive analytical technique to widely used liquid chromatography. It is characterized by low consumption of reagents and organic solvents, as well as relatively short analysis time, which translates into low operating costs and environmental friendliness. Unfortunately, compared to liquid chromatography, the achieved concentration limits of detection (LOD) are significantly higher when using spectrophotometric detection. However, the development of on-line preconcentration techniques has overcome this issue for compounds with hydrophilic characteristics. Nonetheless, for hydrophobic compounds, despite the dynamically evolving separation modes and new pseudostationary phases, there is still a need for new signal enhancement methods. Toxic or pharmacologically active substances present in biological and environmental samples at ultra-trace levels often include hydrophobic compounds, occurring at nanomolar or even picomolar concentrations. Therefore, it is justified to seek new solutions to lower the limits of detection, which will expand knowledge in the field of electromigration techniques for the analysis of hydrophobic compounds. This review summarizes the current achievements in the analysis of hydrophobic compounds using on-line preconcentration techniques in combination with capillary electrokinetic chromatography (CEKC), where separation buffer acts as a pseudostationary phase with which analytes interact.

毛细管电泳（CE）是一种与广泛使用的液相色谱法竞争的分析技术。它的特点是试剂和有机溶剂消耗量低，分析时间相对较短，因此操作成本低且环保。遗憾的是，与液相色谱法相比，使用分光光度法检测时的浓度检测限（LOD）要高得多。不过，在线预浓缩技术的发展克服了亲水性化合物的这一问题。然而，对于疏水性化合物，尽管分离模式和新型伪静止相不断发展，但仍然需要新的信号增强方法。生物和环境样本中存在的超痕量有毒或药理活性物质通常包括疏水性化合物，其浓度可达纳摩尔甚至皮摩尔。因此，有必要寻求新的解决方案来降低检测限，这将拓展疏水化合物分析电迁移技术领域的知识。本综述总结了目前利用在线预浓缩技术结合毛细管电动色谱法（CEKC）分析疏水性化合物的成果，在毛细管电动色谱法中，分离缓冲液充当分析物与之相互作用的假静止相。

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引用次数: 0

Fan assisted extraction and low pressure chromatographic system with a phenyl monolithic column for amperometric determination of volatile α-dicarbonyl compounds in coffee brews 采用苯基整体柱的扇形辅助萃取和低压色谱系统，以安培法测定咖啡冲泡物中的挥发性 α-二羰基化合物

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-19 DOI: 10.1016/j.microc.2024.111689

In this work, a low pressure chromatographic system featuring a single 0.5 cm length phenyl monolithic column and an amperometric detector was developed to determine volatile ⍺-dicarbonyl compounds in coffee brews. The analytical strategy relied on the extraction of the volatile ⍺-dicarbonyl compounds and their derivatization with o-phenylenediamine, prior to the determination of the resulting quinoxaline derivative compounds in the designed chromatographic system. The studies of the mobile phase composition and electrochemical conditions are presented. The extraction of the volatile ⍺-dicarbonyl compounds was performed resourcing to a recent approach based on the fan assisted extraction system. This system performs the full evaporation technique and allowed the quantitative recovery (>85 %) of diacetyl and 2,3-pentanedione from the coffee brew based on the following experimental conditions: sample volume 30 µL, extraction period 15 min, acceptor solution (water, acetonitrile, 90:10, v/v) volume 400 µL, and sample temperature 50 °C. The developed method showed no matrix effect for different coffee brews and the quantification of the studied analytes can be performed through the external calibration method. Detection limits of 3.6 × 10⁻⁶ mol/L for diacetyl and 12.9 × 10⁻⁶ mol/L for 2,3-pentanedione were obtained. Sample analysis rate was of 5 h⁻¹ and the acetonitrile consumption was of ca. 450 µL per chromatographic run.

本研究开发了一种低压色谱系统，采用单根 0.5 厘米长的苯基整体柱和安培检测器，用于测定咖啡冲泡物中的挥发性⍺-二羰基化合物。分析策略依赖于萃取挥发性⍺-二羰基化合物并用邻苯二胺对其进行衍生化，然后在设计的色谱系统中测定由此产生的喹喔啉衍生物化合物。报告介绍了对流动相组成和电化学条件的研究。挥发性⍺-二羰基化合物的萃取采用了基于风扇辅助萃取系统的最新方法。该系统采用全蒸发技术，可从咖啡中定量回收（85%）双乙酰和 2,3-戊二酮，实验条件如下：样品体积 30 µL，萃取时间 15 分钟，接受溶液（水、乙腈，90:10，v/v）体积 400 µL，样品温度 50 °C。所开发的方法对不同的咖啡冲泡物没有基质效应，可通过外部校准法对所研究的分析物进行定量。双乙酰的检测限为 3.6 × 10-6 mol/L，2,3-戊二酮的检测限为 12.9 × 10-6 mol/L。样品分析速度为 5 h-1，每次色谱运行消耗乙腈约 450 µL。

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引用次数: 0

Gabapentin: An impurity profiling approach with hydrogen peroxide induced thermal oxidation in autoclave 加巴喷丁利用高压釜中过氧化氢诱导热氧化的杂质分析方法

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-19 DOI: 10.1016/j.microc.2024.111684

Predicting unconventional pathways in long term stability studies can be very challenging, especially in solid state degradation. This is of vital importance for enhancement in the level of degradation and to further enable the isolation of unknown degradation products. Predicting the mechanism or pathway also help in designing control strategies to minimise the potential chances of impurity formation. In this context, the lagtime of most oxidative degradation mechanisms is extremely important, which allows enough requisite of free radicals etc., one of the unconventional pathways. This is difficult to replicate in degradation studies involving usual solution form. In this investigation, we demonstrate that employing autoclave degradation with hydrogen peroxide conditions provide an enhanced level of an unknown degradation product, which was found to be futile in traditional forced degradation studies. The conditions used probably bypass the lag time. This impurity has been isolated using preparative liquid chromatography (Prep-HPLC) method and spectroscopic techniques like high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance NMR (¹H, ¹³C, DEPT-135, NOESY, APT) for elucidation of the molecular structure. The impurity was identified as a dimer of gabapentin impurity-A (impurity (2,2′-diaza[l,2′-bispiro[4.5]decane]-3,3′-dione) and named it as impurity-U. A plausible mechanism for the formation of isolated impurity is proposed. HPLC methods have been developed and reported for the determination of gabapentin and its related substances using UV detection.

在长期稳定性研究中预测非常规途径是一项非常具有挑战性的工作，尤其是在固态降解方面。这对于提高降解水平和进一步分离未知降解产物至关重要。预测降解机理或途径还有助于设计控制策略，最大限度地减少杂质形成的潜在机会。在这种情况下，大多数氧化降解机制的滞后性极为重要，这使得自由基等非常规途径有足够的必要条件。这在涉及普通溶液形式的降解研究中很难复制。在这项研究中，我们证明了在过氧化氢条件下使用高压釜降解可以提高未知降解产物的水平，而这在传统的强制降解研究中是徒劳的。所使用的条件可能绕过了滞后时间。我们采用制备液相色谱法（Prep-HPLC）和高分辨率质谱法（HRMS）、核磁共振核磁共振法（1H、13C、DEPT-135、NOESY、APT）等光谱技术分离出了这种杂质，以阐明其分子结构。经鉴定，该杂质是加巴喷丁杂质-A（杂质（2,2′-二氮杂[l,2′-双螺[4.5]癸烷]-3,3′-二酮）的二聚体，并将其命名为杂质-U。提出了分离出的杂质的合理形成机制。开发并报告了利用紫外检测法测定加巴喷丁及其相关物质的高效液相色谱法。

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引用次数: 0

Electropolymerized InZnSe@PtAg quantum dots@molecularly imprinted polymer on screen-printed carbon electrodes for the ultrasensitive detection of NS1 dengue virus protein with smartphone-based sensing in saliva 丝网印刷碳电极上的电聚合 InZnSe@PtAg 量子点@分子印迹聚合物用于基于智能手机的唾液中登革热病毒 NS1 蛋白的超灵敏检测

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-19 DOI: 10.1016/j.microc.2024.111704

According to the World Health Organization (WHO), an estimated 100–400 million cases of dengue virus (DENV) infections are recorded annually with half of the global population being at risk of infection. Currently, there is no known treatment for DENV; however, early, rapid and accurate (sensitive and selective) detection can help to alleviate fatality rates. This work reports on the novel development of a point-of-care electrochemical biosensor for DENV using nanostructured InZnSe@PtAg quantum dots (QDs)-molecularly imprinted polymer (MIP) with smartphone-based detection functionality. Highly conductive InZnSe@PtAg QDs were newly synthesized in the presence of metal precursors, organic surfactants and ligands and surface capped with glutathione (GSH) using a ligand exchange reaction. PtAg was used as an electroactive shell layer on the InZnSe QDs core surface to increase the QDs conductivity. The GSH-InZnSe@PtAg QDs were drop-casted onto screen-printed carbon electrodes (SPCEs) and electropolymerized using cyclic voltammetry (CV) in the presence of o-phenylenediamine and the template DENV. The robust electropolymerization process allowed the overcoating of the MIP layer on the QDs/SPCE, where specific DENV size and shape cavities were created. Under optimal experimental conditions, DENV was rapidly, selectively and ultra-sensitively detected. Using differential pulse voltammetry (DPV), quantitative rebinding of DENV on the MIP@QDs/SPCE surface led to a steady decrease of the anodic peak current and a limit of detection of 1.36 pg/mL was obtained for DENV detection. Using a hand-held smartphone-based potentiostat, DENV was successfully detected in human saliva with satisfactory analytic recoveries.

据世界卫生组织（WHO）估计，每年登革热病毒（DENV）感染病例约为 1 亿至 4 亿例，全球有一半人口面临感染风险。目前，还没有已知的治疗登革热病毒的方法；然而，早期、快速和准确（灵敏和选择性）的检测有助于降低死亡率。这项研究报告了利用纳米结构的 InZnSe@PtAg量子点（QDs）-分子印迹聚合物（MIP）和基于智能手机的检测功能，针对 DENV 开发的新型护理点电化学生物传感器。在金属前体、有机表面活性剂和配体的存在下，新合成了高导电性 InZnSe@PtAg QDs，并利用配体交换反应在其表面封端了谷胱甘肽（GSH）。PtAg 用作 InZnSe QDs 核心表面的电活性外壳层，以增加 QDs 的导电性。将 GSH-InZnSe@PtAg QDs 滴铸到丝网印刷碳电极（SPCE）上，并在邻苯二胺和模板 DENV 存在下使用循环伏安法（CV）进行电聚合。稳健的电聚合过程允许在 QDs/SPCE 上覆盖 MIP 层，并在该层上形成特定尺寸和形状的 DENV 空穴。在最佳实验条件下，可快速、选择性和超灵敏地检测 DENV。利用差分脉冲伏安法（DPV），DENV 在 MIP@QDs/SPCE 表面的定量再结合导致阳极峰电流稳步下降，DENV 检测的检测限为 1.36 pg/mL。利用基于智能手机的手持式恒电位仪，成功地检测了人体唾液中的 DENV，分析回收率令人满意。

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引用次数: 0

Trifluoroacetic acid modified MOF-808 composite coating for solid-phase microextraction of six phenols followed by gas chromatography analysis 三氟乙酸改性 MOF-808 复合涂层用于六种酚类化合物的固相微萃取和气相色谱分析

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-19 DOI: 10.1016/j.microc.2024.111694

The development of adsorption materials with good stability and high efficiency is significant in solid-phase microextraction (SPME). In this work, metal–organic framework MOF-808 (Zr) was modified by trifluoroacetic acid (TFA) to improve its hydrophobicity. MOF-808-TFA was electrochemically deposited on stainless steel wire with poly (3, 4-ethylenedioxthiophene) (PEDOT) to increase its extraction efficiency. The main parameters in the synthesis and extraction procedure were optimized. The prepared MOF-808-TFA@PEDOT nanocomposite coating was characterized by scanning electron microscopy, energy dispersive spectrometer, X-ray diffraction, Fourier transform infrared spectrometry and thermogravimetric analysis. A direct immersion solid-phase microextraction (DI-SPME) method for six phenols was developed based on the nanocomposite coating which had good service life (150 times). The extraction efficiency was 12 times higher than the commercial PDMS coating. Combined with gas chromatography-flame ionization detector (GC-FID), a simultaneous determination method for the six phenols was established, which exhibited wide linear range with 0.05–50 μg L⁻¹ (R² > 0.99). The limit of detection was 0.01–0.08 μg L⁻¹ (S/N = 3), and the limit of quantification was 0.05–0.25 μg L⁻¹. The method was applied to determine the migration quantity of phenols from four metal cans with recovery rate between 85.6–116.8 % (RSD < 13.9 %), and it was verified by standard GC–MS method and SPSS statistical analysis. These results indicated the DI-SPME-GC-FID method had reliability and potential application in security testing for food contact materials.

开发稳定性好、效率高的吸附材料对于固相微萃取（SPME）具有重要意义。在这项研究中，三氟乙酸（TFA）对金属有机框架 MOF-808 (Zr) 进行了改性，以提高其疏水性。将 MOF-808-TFA 与聚（3，4-亚乙二氧基噻吩）（PEDOT）电化学沉积在不锈钢丝上，以提高其萃取效率。对合成和萃取过程中的主要参数进行了优化。制备的 MOF-808-TFA@PEDOT 纳米复合涂层通过扫描电子显微镜、能量色散光谱仪、X 射线衍射、傅立叶变换红外光谱和热重分析进行了表征。基于该纳米复合涂层开发了一种直接浸泡固相微萃取（DI-SPME）方法，可萃取六种酚类化合物，该方法具有良好的使用寿命（150 次）。萃取效率是商用 PDMS 涂层的 12 倍。结合气相色谱-火焰离子化检测器（GC-FID）建立了六种酚类化合物的同时测定方法，其线性范围为0.05～50 μg L-1 (R2 > 0.99)。检出限为 0.01-0.08 μg L-1 (S/N = 3)，定量限为 0.05-0.25 μg L-1。应用该方法测定了四种金属罐中酚类物质的迁移量，回收率为 85.6-116.8 % (RSD < 13.9 %)，并通过标准 GC-MS 方法和 SPSS 统计分析进行了验证。这些结果表明，DI-SPME-GC-FID 方法在食品接触材料的安全检测中具有可靠性和应用潜力。

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引用次数: 0

Common and novel methods for the identification of bisphenol A in tea samples: A systematic review study 鉴定茶叶样品中双酚 A 的常用和新型方法：系统回顾研究

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-19 DOI: 10.1016/j.microc.2024.111724

Tea is the most widely consumed beverage in the world, so its safety is of particular importance. Bisphenol A (BPA) is a pollutant that has been identified in the environment. This systematic study was conducted with the focus on the amount of BPA in tea. Searching in databases was done with related keywords without limitation in time. In most studies, bisphenol A has been detected in tea samples. The range of bisphenol A in tea samples is between ND (not detected) and 219 ng/g. In about 28 % of the studies, the level of bisphenol ND has been reported. Conventional and new techniques for measuring bisphenol in tea are also discussed in this manuscript. The common methods are the use of SPE (Solid-Phase Extraction) and QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method. However, novel methods, including the use of covalent organic frameworks and Nano particles, are outstanding researches.

茶是世界上消费量最大的饮料，因此其安全性尤为重要。双酚 A（BPA）是一种已在环境中发现的污染物。本系统研究的重点是茶叶中的双酚 A 含量。在没有时间限制的情况下，使用相关关键词在数据库中进行了搜索。在大多数研究中，茶叶样本中都检测到了双酚 A。茶叶样本中双酚 A 的含量范围在 ND（未检出）和 219 纳克/克之间。约有 28% 的研究报告了双酚 ND 水平。本手稿还讨论了测量茶叶中双酚的传统技术和新技术。常用的方法有固相萃取法（SPE）和QuEChERS（快速、简便、廉价、有效、坚固和安全）法。然而，包括使用共价有机框架和纳米颗粒在内的新型方法也是一项杰出的研究。

引用次数: 0

Recent advances in carbon dots for electrochemical sensing and biosensing: A systematic review 用于电化学传感和生物传感的碳点的最新进展：系统综述

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-19 DOI: 10.1016/j.microc.2024.111687

Carbon dots (CDs) are a class of emerging carbon-based nanomaterials with an average particle size of less than 10 nm. CDs have received considerable attention due to their outstanding characteristics, such as conjugated structure, excellent fluorescent properties, high electrical conductivity, exceptional biocompatibility, negligible toxicity, superior water dispersion, ease of synthesis and feasibility of surface modification. In light of these unique properties, a wide variety of potential applications of CDs have been proposed, including sensing, bioimaging, drug delivery, optoelectronics, photocatalysis, energy storage and conversion, etc. In the field of sensing, CDs are widely used as modified materials to fabricate sensors by simple drop-casting, electrodeposition and inkjet printing process. The analytical performances in electrochemical sensing and biosensing rival or surpass those of other carbon-based nanomaterials, such as graphene and carbon nanotubes. To date, the availability of a comprehensive review focused on electrochemical sensing platform based on CDs with the information on recent progress, analytical performance, and application prospects is lacking. In this review, we aim to summarize the advances in the application of CDs in electrochemical sensing platform for determining environmental contaminants (endocrine disrupting chemicals, heavy metals, pesticides and antibiotics) and biomolecules (proteins, metabolites and amino acids) over the last 5 years. Besides, the challenges and future research directions for CDs-based sensors are discussed.

碳点（CD）是一类平均粒径小于 10 纳米的新兴碳基纳米材料。由于具有共轭结构、优异的荧光特性、高导电性、优异的生物相容性、可忽略的毒性、优异的水分散性、易于合成和表面改性等突出特点，碳点已受到广泛关注。鉴于这些独特的性能，人们提出了 CD 的各种潜在应用，包括传感、生物成像、给药、光电、光催化、能量存储和转换等。在传感领域，CD 被广泛用作改性材料，通过简单的滴铸、电沉积和喷墨打印工艺制作传感器。其在电化学传感和生物传感方面的分析性能可与石墨烯和碳纳米管等其他碳基纳米材料媲美，甚至超过它们。迄今为止，还缺乏一篇关于基于 CD 的电化学传感平台的全面综述，包括最新进展、分析性能和应用前景等方面的信息。在这篇综述中，我们旨在总结过去 5 年来 CD 在电化学传感平台中的应用进展，以测定环境污染物（干扰内分泌的化学物质、重金属、农药和抗生素）和生物大分子（蛋白质、代谢物和氨基酸）。此外，还讨论了基于 CD 的传感器所面临的挑战和未来的研究方向。

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引用次数: 0

A non-enzymatic flexible and wearable sensor based on thermal transfer printing technology for continuous glucose detection in sweat 基于热转印技术的非酶柔性可穿戴传感器，用于连续检测汗液中的葡萄糖

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-19 DOI: 10.1016/j.microc.2024.111690

Non-invasive, flexible wearable sensors are an important method to continuously measure glucose in sweat for diabetes and human health monitoring and management. However, how to create an alkaline environment at any time so that CuO based sensors can be applied to wearable devices to detect sweat glucose while finding a way to efficiently and quickly produce the sensors in small batches have been a challenge. Herein, we report a non-enzymatic thermal transferred flexible and wearable sensor based on CuO/CaTiO₃ for continuous glucose detection in sweat. The sensor is manufactured using thermal transfer printing technology, which offers advantages like low cost, ease of operation, and rapid small batch production. CuO is known for its excellent electrocatalytic activity, making it a suitable candidate for glucose oxidation. Meanwhile, CaTiO₃ particles provide a large specific surface area, good biocompatibility, and electrical conductivity, which enhance the electron transfer rate during detection and broaden the linear range of glucose detection. Specially designed NaOH/Nafion/PEO blend film make the measurements always in a strong alkali environment without any pretreatment and preparation. The synthesized material with this as-prepared flexible and wearable sensor exhibits superior performance towards glucose monitoring, such as high sensitivity of 487.3 μA mM⁻¹ cm⁻² with limit of detection(LOD) 0.75 μM, wide dynamic linear range from 0.01 mM to 2 mM and fast response time of less than 0.1 s. Additionally, the proposed sensor also exhibited excellent biocompatibility, selectivity, reproducibility and flexibility, as well as good stability with about 88 % of its initial activity after 5 weeks’ storage and it has been successfully applied for the detection of glucose concentration in human sweat real samples. This research contributes to the development of flexible and wearable sensors for non-invasive sweat diagnostics, enabling continuous glucose monitoring for various applications in healthcare and wellness.

无创、灵活的可穿戴传感器是持续测量汗液中葡萄糖的重要方法，可用于糖尿病和人体健康监测与管理。然而，如何随时创造碱性环境，以便将基于氧化铜的传感器应用到可穿戴设备中检测汗液葡萄糖，同时找到高效、快速地小批量生产传感器的方法，一直是一个难题。在此，我们报告了一种基于 CuO/CaTiO3 的非酶热转印柔性可穿戴传感器，用于连续检测汗液中的葡萄糖。该传感器采用热转印印刷技术制造，具有成本低、操作简便和小批量快速生产等优点。众所周知，CuO 具有出色的电催化活性，因此适合用于葡萄糖氧化。同时，CaTiO3 颗粒具有较大的比表面积、良好的生物相容性和导电性，可提高检测过程中的电子转移率，扩大葡萄糖检测的线性范围。特殊设计的 NaOH/Nafion/PEO 混合膜使测量始终在强碱环境中进行，无需任何预处理和准备。合成的这种柔性可穿戴传感器材料在葡萄糖监测方面表现出卓越的性能，例如灵敏度高达 487.3 μA mM-1 cm-2，检测限（LOD）为 0.75 μM，动态线性范围从 0.01 mM 到 2 mM，响应时间小于 0.1 秒。此外，所提出的传感器还具有良好的生物相容性、选择性、再现性和灵活性，以及储存 5 周后约 88% 的初始活性的良好稳定性，并已成功应用于人体汗液真实样本中葡萄糖浓度的检测。这项研究有助于开发用于无创汗液诊断的柔性可穿戴传感器，从而为医疗保健和健康领域的各种应用提供连续葡萄糖监测。

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引用次数: 0

Recent advances in detection of aflatoxins using carbon dots: A review 利用碳点检测黄曲霉毒素的最新进展：综述

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-19 DOI: 10.1016/j.microc.2024.111708

Aflatoxins are extremely harmful and cancer-causing substances generated by specific fungi that can contaminate various agricultural products, posing serious health risks to humans, food safety, and animals. Due to their high liposolubility, aflatoxins are readily absorbed into the bloodstream through the gastrointestinal and respiratory tracts. Given their resilience and widespread occurrence, aflatoxins continue to be a global concern, necessitating continuous monitoring and the development of innovative detection methods to protect public health and ensure food security. The emergence of carbon dots (CDs) presents a promising avenue for rapidly detecting aflatoxins. CDs offer numerous advantages, including negligible cytotoxicity, water solubility, biocompatibility, chemical stability, efficient light absorption, and exceptional photoinduced electron transfer. Despite these benefits the literature contains some novel reports on using CDs for aflatoxin detection, but lacks a review article. Therefore, this review article explores novel, and emerging detection methods for aflatoxins, such as colorimetric, fluorometric, electrochemical, and electrogenerated chemiluminescence techniques, focusing on the use of modified and unmodified CDs. It also demonstrates how multi-recognition elements are combined with CDs to improve selectivity, sensitivity, and stability for aflatoxin detection. Finally, challenges and limitations for future CDs implementation in real-world assays are discussed.

黄曲霉毒素是由特定真菌产生的极为有害的致癌物质，可污染各种农产品，对人类健康、食品安全和动物造成严重危害。由于黄曲霉毒素具有很高的脂溶性，很容易通过胃肠道和呼吸道被人体吸收进入血液。鉴于黄曲霉毒素的顽强生命力和广泛存在，黄曲霉毒素仍然是一个全球关注的问题，因此有必要对其进行持续监测，并开发创新的检测方法，以保护公众健康和确保食品安全。碳点（CD）的出现为快速检测黄曲霉毒素提供了一条前景广阔的途径。碳点具有众多优点，包括可忽略的细胞毒性、水溶性、生物相容性、化学稳定性、高效的光吸收和出色的光诱导电子传递。尽管有这些优点，文献中仍有一些关于使用光盘检测黄曲霉毒素的新报道，但缺乏综述文章。因此，这篇综述文章探讨了新出现的黄曲霉毒素检测方法，如比色法、荧光法、电化学法和电致化学发光技术，重点介绍了改性和未改性光盘的使用。报告还展示了如何将多种识别元素与光盘相结合，以提高黄曲霉毒素检测的选择性、灵敏度和稳定性。最后，还讨论了未来在实际检测中使用光盘所面临的挑战和限制。

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引用次数: 0

Mof-mediated paper-based (bio)sensors for detecting of food and environmental pollutants: Preparation strategies and emerging applications 用于检测食品和环境污染物的 Mof 介导纸基（生物）传感器：制备策略和新兴应用

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-19 DOI: 10.1016/j.microc.2024.111692

The issue of food safety, which is intricately related to the economic progress of the food industry and public health, has emerged as a significant global concern that is receiving increasing attention worldwide. The implementation of efficient detection technologies plays a vital role in ensuring the safety of food products. In recent years, there has been significant advancement in the progress of POCT (point-of-care testing) biosensors, driven by the increasing demand for rapid and home testing. Paper-based biosensors have emerged as a prominent category within the realm of POCT biosensors, primarily because of their cost-effectiveness, simplicity, and portability. In order to address the growing need for POCT in a variety of applications, there is a highly demanded for the functionalization of paper substrates. Metal-organic framework (MOF), a versatile porous nanomaterial, is presented in the fabrication of paper-derived platforms, meaningfully boosting the detecting feature and application potential. This study offers an overview of the latest developments and emerging trends in MOF-functionalized paper-based biosensors (MOF@paper), encompassing various kinds of substrates, construction techniques, diagnosis applications and mechanisms. Due to the superior performance and multifunctionality of MOF@paper biosensors, this area shows promising prospects in scientific research, food safety, and control applications.

食品安全问题与食品工业的经济发展和公众健康息息相关，已成为全球关注的一个重要问题，受到全世界越来越多的关注。高效检测技术的应用在确保食品安全方面发挥着至关重要的作用。近年来，在快速检测和家庭检测需求日益增长的推动下，POCT（床旁检测）生物传感器取得了长足的进步。纸质生物传感器已成为 POCT 生物传感器领域的一个重要类别，这主要是因为它们具有成本效益、简便和便携的特点。为了满足各种应用中日益增长的对 POCT 的需求，人们对纸基底的功能化提出了很高的要求。金属有机框架（MOF）是一种多功能多孔纳米材料，可用于制造纸基平台，大大提高检测功能和应用潜力。本研究概述了 MOF 功能化纸基生物传感器（MOF@paper）的最新发展和新兴趋势，包括各种基底、构建技术、诊断应用和机制。由于 MOF@paper 生物传感器的优越性能和多功能性，该领域在科学研究、食品安全和控制应用方面前景广阔。

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