I. Ahmad, M. Rashid, Shahid Nawaz, M. Asif, T. H. Farooq, Zainab Shahbaz, M. Kashif, M. Shaheen
Bombax ceiba is an important agroforestry tree species widely distributed throughout the world. It has been extensively grown and planted for eras in hot and dry regions and high humidity zones of southern Asia. The main objective of this research was to evaluate the growth response of B. ceiba in response to different compost treatments. Different morphological traits (plant height, stem height, root length) and biomass (shoot fresh weight, shoot dry weight, root fresh weight, root dry weight and root/shoot ratio) were measured. Two experiments (pot experiment = seedlings) and (field experiment = saplings) were conducted simultaneously. Different compost treatments: (T0) = (Compost 0% + Soil 0%), (T1) = (Compost 25% + Soil 75%), (T2) = (Compost 50% + Soil 50%), (T3) = (Compost 75% + Soil 25%), (T4) = (Compost 100% + Soil 0%) were applied in the growing media. Results demonstrated that plant growth increased with the increment in compost application. In the pot experiment, B. ceiba exhibited its better growth under 75% of compost application, whereas in the field experiment, 100% compost was helpful for the best production of B. ceiba. Overall, positive effects of compost were observed for the growth of B. ceiba. The plant growth was increased greatly in response to the better content of organic fertilizer, and it was determined that compost enhances soil fertility. It should be implemented as organic fertilizer in agroforestry operations for optimizing plant growth and yield.
{"title":"Effect of different compost concentrations on the growth yield of Bombax Ceiba (Simal)","authors":"I. Ahmad, M. Rashid, Shahid Nawaz, M. Asif, T. H. Farooq, Zainab Shahbaz, M. Kashif, M. Shaheen","doi":"10.53365/nrfhh/144578","DOIUrl":"https://doi.org/10.53365/nrfhh/144578","url":null,"abstract":"Bombax ceiba is an important agroforestry tree species widely distributed throughout the world. It has been extensively grown and planted for eras in hot and dry regions and high humidity zones of southern Asia. The main objective of this research was to evaluate the growth response of B. ceiba in response to different compost treatments. Different morphological traits (plant height, stem height, root length) and biomass (shoot fresh weight, shoot dry weight, root fresh weight, root dry weight and root/shoot ratio) were measured. Two experiments (pot experiment = seedlings) and (field experiment = saplings) were conducted simultaneously. Different compost treatments: (T0) = (Compost 0% + Soil 0%), (T1) = (Compost 25% + Soil 75%), (T2) = (Compost 50% + Soil 50%), (T3) = (Compost 75% + Soil 25%), (T4) = (Compost 100% + Soil 0%) were applied in the growing media. Results demonstrated that plant growth increased with the increment in compost application. In the pot experiment, B. ceiba exhibited its better growth under 75% of compost application, whereas in the field experiment, 100% compost was helpful for the best production of B. ceiba. Overall, positive effects of compost were observed for the growth of B. ceiba. The plant growth was increased greatly in response to the better content of organic fertilizer, and it was determined that compost enhances soil fertility. It should be implemented as organic fertilizer in agroforestry operations for optimizing plant growth and yield.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133191882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laurent Voufack Lefack Bongmo, G. Happi, G. B. Tabekoueng, M. Lateef, Alain François Kamdem Waffo, Muhammad Shaiq Ali, M. Iqbal Choudhary, A. Nouga, Jean Duplex Wansi
Thirteen compounds (1‒13) were isolated and identified during phytochemical analysis of the leaves and stem bark of Guibourtia ehie (A. Chev) J. Leonard. Spectroscopic and spectrometric methods and the comparison of their results with those given in the literature were used to ascertain their structures. Furthermore, the acetylation of 3,3′-di-O-methylellagic acid 4′-O-β-D-xylopyranoside (2) afforded a new derivative 3,3′-di-O-methylellagic acid 4′-O-β-D-(4,2′′,4′′-triacetyl)-xylopyranoside (2a). Extracts, fractions, and isolated compounds were assessed for their antioxidant, urease, and α-glucosidase inhibitory activities. Compound 1 demonstrated potent antioxidant activity in the DPPH with an IC50 value of 36.4 ± 0.2 µM, while rhaponticin (3), 2,6-dimethoxybenzoquinone (4), and taraxerol (6) exhibited a strong α-glucosidase inhibitory activity with the IC50 values of 35.5 ± 0.1, 25.5 ± 0.2 and 43.4 ± 0.3 µM, respectively. The present study enriches the chemistry of Guiboutia ehie and provides further evidence on its bioactive constituents, which might help in the development of hypoglycaemic drugs.
从桂叶(Guibourtia ehie (A. Chev) J. Leonard)的叶和茎皮中分离鉴定了13个化合物(1 ~ 13)。采用光谱学和光谱分析方法，并与文献中给出的结果进行比较，确定了它们的结构。此外，3,3 ' -二- o -甲基鞣皮酸4 ' - o -β- d -木吡喃苷(2)的乙酰化得到了新的衍生物3,3 ' -二- o -甲基鞣皮酸4 ' - o -β- d -(4,2 '，4 ' -三乙酰基)-木吡喃苷(2a)。对提取物、馏分和分离化合物的抗氧化、脲酶和α-葡萄糖苷酶抑制活性进行了评估。化合物1对DPPH具有较强的抗氧化活性，IC50值为36.4±0.2µM，而rhaponticin(3)、2,6-二甲氧基苯醌(4)和taraxerol(6)具有较强的α-葡萄糖苷酶抑制活性，IC50值分别为35.5±0.1、25.5±0.2和43.4±0.3µM。本研究丰富了桂皮的化学成分，为其生物活性成分的研究提供了进一步的证据，有助于开发降糖药物。
{"title":"Phytochemical compounds of Guibourtia ehie and their antioxidant, urease and α-glucosidase inhibitory activities","authors":"Laurent Voufack Lefack Bongmo, G. Happi, G. B. Tabekoueng, M. Lateef, Alain François Kamdem Waffo, Muhammad Shaiq Ali, M. Iqbal Choudhary, A. Nouga, Jean Duplex Wansi","doi":"10.53365/nrfhh/145341","DOIUrl":"https://doi.org/10.53365/nrfhh/145341","url":null,"abstract":"Thirteen compounds (1‒13) were isolated and identified during phytochemical analysis of the leaves and stem bark of Guibourtia ehie (A. Chev) J. Leonard. Spectroscopic and spectrometric methods and the comparison of their results with those given in the literature were used to ascertain their structures. Furthermore, the acetylation of 3,3′-di-O-methylellagic acid 4′-O-β-D-xylopyranoside (2) afforded a new derivative 3,3′-di-O-methylellagic acid 4′-O-β-D-(4,2′′,4′′-triacetyl)-xylopyranoside (2a). Extracts, fractions, and isolated compounds were assessed for their antioxidant, urease, and α-glucosidase inhibitory activities. Compound 1 demonstrated potent antioxidant activity in the DPPH with an IC50 value of 36.4 ± 0.2 µM, while rhaponticin (3), 2,6-dimethoxybenzoquinone (4), and taraxerol (6) exhibited a strong α-glucosidase inhibitory activity with the IC50 values of 35.5 ± 0.1, 25.5 ± 0.2 and 43.4 ± 0.3 µM, respectively. The present study enriches the chemistry of Guiboutia ehie and provides further evidence on its bioactive constituents, which might help in the development of hypoglycaemic drugs.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131990943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Salomon, Ivana Brodkiewicz, Gerardo P. Gennari, L. Maldonado, C. Romero, N. Vera
Despite all the advantages of consuming meliponid honey, meliponiculture has not been sufficiently promoted in Argentina yet, and published studies on these species of bees are very scarce. Tetragonisca fiebrigi honey (TfH) or Yateí honey has recently been incorporated into the Argentine food code. This study assesses antioxidant, anti-inflammatory and analgesic properties and acute toxicity by oral administration of TfH in rats. In addition, we present the melissopalynological analysis and physicochemical characterization. High-performance liquid chromatography identifies and quantifies sugars and phenolic compounds. The T. fiebrigi honey analyzed exhibited ABTS•+ and DPPH radical scavenging effect (IC50= 98.28 mg/ml and IC50=337.83 mg/ml, respectively). A significant reduction in hind paw edema (44.44%) was observed in rats pretreated with TfH honey (1000 mg/kg b.w.) 3.0 h after dosing and significantly reduced transudative and granuloma weights at all doses tested (27.34%, 35.53% and 47.53% granuloma inhibition). The TfH honey oral administration produced analgesic responses in the three models used (acetic acid, formalin, tail immersion). Ferulic, ellagic, coumaric, gallic, cinnamic acids and the flavonoids quercetin and hesperetin were identified and quantified. Fructose (40.9%), glucose (29.02%) and sucrose (1.06%) were the main sugars. TfH honey administration did not produce lethal effects or clinical signs of disease in the acute toxicity study. The results showed that T. fiebrigi honey could be a good source of bioactive natural compounds with therapeutic and nutritional value.
{"title":"Argentine stingless bee honey: bioactive compounds and health-promoting properties","authors":"V. Salomon, Ivana Brodkiewicz, Gerardo P. Gennari, L. Maldonado, C. Romero, N. Vera","doi":"10.53365/nrfhh/144727","DOIUrl":"https://doi.org/10.53365/nrfhh/144727","url":null,"abstract":"Despite all the advantages of consuming meliponid honey, meliponiculture has not been sufficiently promoted in Argentina yet, and published studies on these species of bees are very scarce. Tetragonisca fiebrigi honey (TfH) or Yateí honey has recently been incorporated into the Argentine food code. This study assesses antioxidant, anti-inflammatory and analgesic properties and acute toxicity by oral administration of TfH in rats. In addition, we present the melissopalynological analysis and physicochemical characterization. High-performance liquid chromatography identifies and quantifies sugars and phenolic compounds. The T. fiebrigi honey analyzed exhibited ABTS•+ and DPPH radical scavenging effect (IC50= 98.28 mg/ml and IC50=337.83 mg/ml, respectively). A significant reduction in hind paw edema (44.44%) was observed in rats pretreated with TfH honey (1000 mg/kg b.w.) 3.0 h after dosing and significantly reduced transudative and granuloma weights at all doses tested (27.34%, 35.53% and 47.53% granuloma inhibition). The TfH honey oral administration produced analgesic responses in the three models used (acetic acid, formalin, tail immersion). Ferulic, ellagic, coumaric, gallic, cinnamic acids and the flavonoids quercetin and hesperetin were identified and quantified. Fructose (40.9%), glucose (29.02%) and sucrose (1.06%) were the main sugars. TfH honey administration did not produce lethal effects or clinical signs of disease in the acute toxicity study. The results showed that T. fiebrigi honey could be a good source of bioactive natural compounds with therapeutic and nutritional value.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125916689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nigella sativa L. seeds are widely used in Sudan as a spice, food preservative, and medicine. Sudan does not grow the plant. The study aimed to compare the chemical profile and antibacterial activity of fixed and essential oils of N. sativa from Ethiopian and Indian seeds and the oil offered by Attarin in the local market. A Soxhlet device extracted fixed oils and hydrodistillation to obtain essential oils and analysed their oil profile using GC-MS. Disk diffusion was used to test antimicrobial activity. The fixed oil of Ethiopian (EFO) and Indian (IFO) seeds contained ten components, with linoleic acid (50.12% in EFO and 57.69% in IFO) being the most abundant. Ethiopian seeds were used to extract the essential oil. 51.96% of the oil was hydrogenated monoterpenes. The main chemicals were p-cymene (36.76%) and thymoquinone (18.70%). There were fixed and essential oils in the Attarin oil sample. The main component was linoleic acid (14.61%), followed by p-cymene (13.85%). The maximum antibacterial activity (MIC 6.25 µg/disc) was seen in both fixed and liquid oil samples against Escherichia coli and Pseudomonas aeruginosa. The best anti-P. aeruginosa action was attarin oil (MIC 12.5 µg/disc). Finally, the Sudanese market needs to standardise N. sativa seeds and oil.
{"title":"Comparative chemical profiling and antimicrobial activity of Nigella sativa seeds oils obtained from different sources","authors":"Fatima Tahir, M. Sonibare, S. Yagi","doi":"10.53365/nrfhh/144320","DOIUrl":"https://doi.org/10.53365/nrfhh/144320","url":null,"abstract":"Nigella sativa L. seeds are widely used in Sudan as a spice, food preservative, and medicine. Sudan does not grow the plant. The study aimed to compare the chemical profile and antibacterial activity of fixed and essential oils of N. sativa from Ethiopian and Indian seeds and the oil offered by Attarin in the local market. A Soxhlet device extracted fixed oils and hydrodistillation to obtain essential oils and analysed their oil profile using GC-MS. Disk diffusion was used to test antimicrobial activity. The fixed oil of Ethiopian (EFO) and Indian (IFO) seeds contained ten components, with linoleic acid (50.12% in EFO and 57.69% in IFO) being the most abundant. Ethiopian seeds were used to extract the essential oil. 51.96% of the oil was hydrogenated monoterpenes. The main chemicals were p-cymene (36.76%) and thymoquinone (18.70%). There were fixed and essential oils in the Attarin oil sample. The main component was linoleic acid (14.61%), followed by p-cymene (13.85%). The maximum antibacterial activity (MIC 6.25 µg/disc) was seen in both fixed and liquid oil samples against Escherichia coli and Pseudomonas aeruginosa. The best anti-P. aeruginosa action was attarin oil (MIC 12.5 µg/disc). Finally, the Sudanese market needs to standardise N. sativa seeds and oil.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132882341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huma Bhatti, R. Rubina, Faisal Rashid, S. Zaib, J. Iqbal, A. Hameed
In our current study, a series of reactions with isolated natural flavonoids (2-phenylchromen-4-one) and flavanone (2,3-dihydro-2-phenylchromen-4-one) through Mannich base was carried out by a one-pot three-component reaction. Their structure-activity relationship study (SAR) reveals the anticancer activity of natural compounds and their Mannich bases. The flavones were substituted by imine at position C-8, while in the flavanones, the reaction takes place at positions C-8 and C-3. Spectroscopic techniques characterized all the isolated and newly synthesized derivatives. Anticancer activity was checked on HeLa and MCF-7 (cancer cell lines) and BHK-21 (normal cell line). Using propidium iodide (PI) and DAPI staining as fluorescence microscopic imaging was confirmed the Apoptotic effect of potent compound. Further, it was evaluated by cell cycle analysis through flow-cytometry, reactive oxygen species and lactate dehydrogenase production. The caspase-9 and -3 activity were estimated by mitochondrial membrane potential. Derivative of naringenin, ((2S)-4′,5,7-Trihydroxyflavan-4-one) where reactions occur at position C-3 were active than others.
{"title":"Synthesis and antitumor activities of novel Mannich base derivatives derived from natural flavonoids","authors":"Huma Bhatti, R. Rubina, Faisal Rashid, S. Zaib, J. Iqbal, A. Hameed","doi":"10.53365/nrfhh/141866","DOIUrl":"https://doi.org/10.53365/nrfhh/141866","url":null,"abstract":"In our current study, a series of reactions with isolated natural flavonoids (2-phenylchromen-4-one) and flavanone (2,3-dihydro-2-phenylchromen-4-one) through Mannich base was carried out by a one-pot three-component reaction. Their structure-activity relationship study (SAR) reveals the anticancer activity of natural compounds and their Mannich bases. The flavones were substituted by imine at position C-8, while in the flavanones, the reaction takes place at positions C-8 and C-3. Spectroscopic techniques characterized all the isolated and newly synthesized derivatives. Anticancer activity was checked on HeLa and MCF-7 (cancer cell lines) and BHK-21 (normal cell line). Using propidium iodide (PI) and DAPI staining as fluorescence microscopic imaging was confirmed the Apoptotic effect of potent compound. Further, it was evaluated by cell cycle analysis through flow-cytometry, reactive oxygen species and lactate dehydrogenase production. The caspase-9 and -3 activity were estimated by mitochondrial membrane potential. Derivative of naringenin, ((2S)-4′,5,7-Trihydroxyflavan-4-one) where reactions occur at position C-3 were active than others.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129608268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Shahwan, Naema El Aali, Yusra Layas, Salem G. El Tumi
Medicinal plants have varying natural products and several antioxidants. Antioxidants play a principal function to protect against destruction caused by oxidative stress (OS), Rheum emodi is not an exception, in which it is reported to have compounds that possess antioxidant activity, like polyphenolic compounds. In addition to that, other compounds have proven to have antidiabetic, antimicrobial, antifungal, cytotoxic, hepatoprotective, and nephroprotective activities. This study aimed to quantify the water extract of a powdered plant of R. emodi to evaluate its ability to scavage free radicals. Total phenolic, total flavonoid contents, and reducing ability were measured to consider possible sources of future novel antioxidants in plants. The TPC, TFC, and reducing power assay increased with increasing concentrations of R. emodi. At 1000 µg/ml, the absorbance ranged from 1.437 for TPC, 1.602 for TFC, and 1.638 for reducing power assay, which is more than the absorbance of the standards at the same concentration. The extracted content of reducing power, phenolic, and flavonoid compounds were higher than the standard pyrogallol, quercetin, and ascorbic acid.
{"title":"Phytochemical content and antioxidant activities of Rhubarb (Rheum emodi)","authors":"A. Shahwan, Naema El Aali, Yusra Layas, Salem G. El Tumi","doi":"10.53365/nrfhh/144015","DOIUrl":"https://doi.org/10.53365/nrfhh/144015","url":null,"abstract":"Medicinal plants have varying natural products and several antioxidants. Antioxidants play a principal function to protect against destruction caused by oxidative stress (OS), Rheum emodi is not an exception, in which it is reported to have compounds that possess antioxidant activity, like polyphenolic compounds. In addition to that, other compounds have proven to have antidiabetic, antimicrobial, antifungal, cytotoxic, hepatoprotective, and nephroprotective activities. This study aimed to quantify the water extract of a powdered plant of R. emodi to evaluate its ability to scavage free radicals. Total phenolic, total flavonoid contents, and reducing ability were measured to consider possible sources of future novel antioxidants in plants. The TPC, TFC, and reducing power assay increased with increasing concentrations of R. emodi. At 1000 µg/ml, the absorbance ranged from 1.437 for TPC, 1.602 for TFC, and 1.638 for reducing power assay, which is more than the absorbance of the standards at the same concentration. The extracted content of reducing power, phenolic, and flavonoid compounds were higher than the standard pyrogallol, quercetin, and ascorbic acid.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"202 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123040676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monica Silva, C. Moya, Juan Landeros-Gutierrez, P. García-López, M. Ruiz-López
Mistletoe (Psittacanthus calyculatus) is used for the prevention and treatment of numerous diseases. Samples of leaves from P. calyculatus were collected in April of 2019, and prepared an aqueous extract. The extract was lyophilized, and its polyphenols, flavonoids, and anthocyanins content were determined. Then, concentrations of lyophilized extract were prepared (5, 50 and 100 ppm) and assessed their antigenotoxic, antimutagenic and genotoxicity activities in human lymphocytes were evaluated using the comet assay system. The dry aqueous extract contained 73.54 mg of polyphenols AGE per g sample, 39.37 mg of flavonoid CE per g, and 0.1 mg of anthocyanins Cy-3-gluc E per g. No significant genotoxic activity was observed, with the exception of the concentration of 100 ppm at 10 hours of exposure (p <0.05). There was also significant (p <0.05) antigenotoxic and antimutagenic activity (p <0.05). Clearly, low concentrations and short-duration exposures to lyophilized P. calyculatus do not induce genetic damage; however, high concentrations are genotoxic. The antigenotoxic and antimutagenic effects were due to a protective effect not only against induced DNA damage but also against basal genetic damage.
{"title":"Antigenotoxic and antimutagenic activities of Psittacanthus calyculatus (Loranthaceae) leaves water extract","authors":"Monica Silva, C. Moya, Juan Landeros-Gutierrez, P. García-López, M. Ruiz-López","doi":"10.53365/nrfhh/144010","DOIUrl":"https://doi.org/10.53365/nrfhh/144010","url":null,"abstract":"Mistletoe (Psittacanthus calyculatus) is used for the prevention and treatment of numerous diseases. Samples of leaves from P. calyculatus were collected in April of 2019, and prepared an aqueous extract. The extract was lyophilized, and its polyphenols, flavonoids, and anthocyanins content were determined. Then, concentrations of lyophilized extract were prepared (5, 50 and 100 ppm) and assessed their antigenotoxic, antimutagenic and genotoxicity activities in human lymphocytes were evaluated using the comet assay system. The dry aqueous extract contained 73.54 mg of polyphenols AGE per g sample, 39.37 mg of flavonoid CE per g, and 0.1 mg of anthocyanins Cy-3-gluc E per g. No significant genotoxic activity was observed, with the exception of the concentration of 100 ppm at 10 hours of exposure (p <0.05). There was also significant (p <0.05) antigenotoxic and antimutagenic activity (p <0.05). Clearly, low concentrations and short-duration exposures to lyophilized P. calyculatus do not induce genetic damage; however, high concentrations are genotoxic. The antigenotoxic and antimutagenic effects were due to a protective effect not only against induced DNA damage but also against basal genetic damage.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130441841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-19 pandemic is a highly challenging situation and affects people's lives severely. Nowadays, the original coronavirus gets mutated into different variants and infects all age groups. Elderly people with comorbidities like diabetes are highly susceptible to coronavirus infection due to poor glycemic control, and immunity. The mechanism of COVID-19 infection is not fully understood. However, the scenario of current infection is similar to the history of pandemics that the world faced earlier (i.e.) the persisted hyperglycemia is considered as the major root cause of severe viral infections. The uncontrolled hyperglycemia can produce low-grade inflammation and impaired immunity mediated cytokine storm that can cause multiple organs failure and sudden death in diabetic patients with COVID-19 infection. The available hypoglycemic and antiviral drugs and vaccines are not sufficiently efficient against COVID-19 and also cause several side effects. As the traditional medicines are considered life-saving drugs for various human diseases, the present review has analyzed the herbs-spices with antiviral, antidiabetic, antioxidant, anti-inflammatory, and immunomodulatory properties. The intake of this herbal-spices formulation could exert both therapeutic and prophylactic effects against the COVID-19. However, the proper scientific studies are necessary for the validation of its efficacy and mode of action against COVID-19.
{"title":"Herbal spices-based therapeutics for diabetic patients with COVID-19 infection: A review","authors":"R. Panchamoorthy, N. Vel","doi":"10.53365/nrfhh/143758","DOIUrl":"https://doi.org/10.53365/nrfhh/143758","url":null,"abstract":"The COVID-19 pandemic is a highly challenging situation and affects people's lives severely. Nowadays, the original coronavirus gets mutated into different variants and infects all age groups. Elderly people with comorbidities like diabetes are highly susceptible to coronavirus infection due to poor glycemic control, and immunity. The mechanism of COVID-19 infection is not fully understood. However, the scenario of current infection is similar to the history of pandemics that the world faced earlier (i.e.) the persisted hyperglycemia is considered as the major root cause of severe viral infections. The uncontrolled hyperglycemia can produce low-grade inflammation and impaired immunity mediated cytokine storm that can cause multiple organs failure and sudden death in diabetic patients with COVID-19 infection. The available hypoglycemic and antiviral drugs and vaccines are not sufficiently efficient against COVID-19 and also cause several side effects. As the traditional medicines are considered life-saving drugs for various human diseases, the present review has analyzed the herbs-spices with antiviral, antidiabetic, antioxidant, anti-inflammatory, and immunomodulatory properties. The intake of this herbal-spices formulation could exert both therapeutic and prophylactic effects against the COVID-19. However, the proper scientific studies are necessary for the validation of its efficacy and mode of action against COVID-19.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133575746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yamuna Annadurai, B. Balasubramanian, V. Arumugam, Wenchao Liu, K. Pushparaj, M. Pappusamy, Haripriya Kuchi Bhotla, A. Meyyazhagan, Murugesh Easwaran, Shanmughavel Piramanayagam
Activities of anthropological organisms lead to the production of massive lignocellulosic waste every year and these lignocellulolytic enzymes plays crucial role in developing eco-friendly, sustainable and economical methods for decomposing and pre-treating the biomass to produce biofuels, organic acids, feeds and enzymes. Lignocellulolytic enzymes sustainably hydrolyse the biomass and can be utilized in wide range of applications such as personal care, pharmaceutical, biofuel release, sewage treatment, food and beverage industries. Every year a significant ton of biomass waste is released and insight on these crucial enzymes could establish in all the industries. However, due to the increased demand for compost materials, biomass degradation has resulted in composting processes. Several methods for improving compost amount and quality have been explored, including increasing decomposer inoculums, stimulating microbial activity, and establishing a decomposable environment. All of these prerequisites are met by biotechnological applications. Biotechnological procedures are used to improve the activity of enzymes on biomass. It leads to an adequate supply of compost and base materials for enterprises. In terms of effectiveness and stability during the breakdown process, lignocellulolytic enzymes derived from genetically modified species outperformed naturally derived lignocellulolytic enzymes. It has the potential to increase the quality and output of by-products. This review discussed the development of lignocellulolytic enzyme families and their widespread applications in a variety of industries such as olive oil extraction, carotenoid extraction, waste management, pollution control, second-generation bio-ethanol production, textile and dyeing, pharmaceuticals, pulp and paper, animal feed, food processing industries, detergent, and agricultural industries.
{"title":"Comprehensive strategies of Lignocellulolytic enzyme production from microbes and their applications in various commercial-scale faculties","authors":"Yamuna Annadurai, B. Balasubramanian, V. Arumugam, Wenchao Liu, K. Pushparaj, M. Pappusamy, Haripriya Kuchi Bhotla, A. Meyyazhagan, Murugesh Easwaran, Shanmughavel Piramanayagam","doi":"10.53365/nrfhh/143683","DOIUrl":"https://doi.org/10.53365/nrfhh/143683","url":null,"abstract":"Activities of anthropological organisms lead to the production of massive lignocellulosic waste every year and these lignocellulolytic enzymes plays crucial role in developing eco-friendly, sustainable and economical methods for decomposing and pre-treating the biomass to produce biofuels, organic acids, feeds and enzymes. Lignocellulolytic enzymes sustainably hydrolyse the biomass and can be utilized in wide range of applications such as personal care, pharmaceutical, biofuel release, sewage treatment, food and beverage industries. Every year a significant ton of biomass waste is released and insight on these crucial enzymes could establish in all the industries. However, due to the increased demand for compost materials, biomass degradation has resulted in composting processes. Several methods for improving compost amount and quality have been explored, including increasing decomposer inoculums, stimulating microbial activity, and establishing a decomposable environment. All of these prerequisites are met by biotechnological applications. Biotechnological procedures are used to improve the activity of enzymes on biomass. It leads to an adequate supply of compost and base materials for enterprises. In terms of effectiveness and stability during the breakdown process, lignocellulolytic enzymes derived from genetically modified species outperformed naturally derived lignocellulolytic enzymes. It has the potential to increase the quality and output of by-products. This review discussed the development of lignocellulolytic enzyme families and their widespread applications in a variety of industries such as olive oil extraction, carotenoid extraction, waste management, pollution control, second-generation bio-ethanol production, textile and dyeing, pharmaceuticals, pulp and paper, animal feed, food processing industries, detergent, and agricultural industries.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114994506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Happi, Livine Zemo Meikeu, Klev Gaïtan Sikam, Liliane Clotilde Dzouemo, J. Wansi
Mushrooms represent a large family of fleshy fungi that have been of high interest since ancient ages due to their medicinal and nutritional importance. Therefore, it can represent a significant source of bioactive compounds in malaria control. The few numbers of studies on in vitro antiplasmodial and insecticidal properties of their extracts and chemical constituents led to interesting results reported in numerous scientific publications. This review aims to provide a comprehensive compilation of literature up to 2021 on the antiplasmodial, insecticidal as well as cytotoxic chemical constituents of medicinal mushrooms that can help in the management of malaria both against the parasite Plasmodium falciparum and the mosquitoe Anopheles stephensis acting as a vector of malaria through its bites. For this purpose, some searches have been done in some online libraries using keywords like Basidiomycete, mushroom, malaria, Plasmodium, Anopheles and antiplasmodial without language restriction. Among the reported compounds, 51 selected ones displayed significant antiplasmodial potency with IC50 values lower than 10 μM against P. falciparum strains sensitive or resistant to chloroquine. For instance, ganoderic acid AW1 demonstrated a strong antiplasmodial activity with IC50 of 257.8 nM against P. falciparum D6, while strong activities were displayed by ganoweberianones A (IC50 = 0.050 μM) and B (IC50 = 0.46 μM) against P. falciparum K1. Moreover, some mushroom methanol extracts demonstrated good larvicidal and ovicidal activities against Anopheles stephensis. This paper provides further insights into the development of new antiplasmodial drugs or new potent eco-friendly pesticides to control mosquito vectors.
{"title":"Mushrooms (Basidiomycetes) as a significant source of biologically active compounds for malaria control","authors":"G. Happi, Livine Zemo Meikeu, Klev Gaïtan Sikam, Liliane Clotilde Dzouemo, J. Wansi","doi":"10.53365/nrfhh/143570","DOIUrl":"https://doi.org/10.53365/nrfhh/143570","url":null,"abstract":"Mushrooms represent a large family of fleshy fungi that have been of high interest since ancient ages due to their medicinal and nutritional importance. Therefore, it can represent a significant source of bioactive compounds in malaria control. The few numbers of studies on in vitro antiplasmodial and insecticidal properties of their extracts and chemical constituents led to interesting results reported in numerous scientific publications. This review aims to provide a comprehensive compilation of literature up to 2021 on the antiplasmodial, insecticidal as well as cytotoxic chemical constituents of medicinal mushrooms that can help in the management of malaria both against the parasite Plasmodium falciparum and the mosquitoe Anopheles stephensis acting as a vector of malaria through its bites. For this purpose, some searches have been done in some online libraries using keywords like Basidiomycete, mushroom, malaria, Plasmodium, Anopheles and antiplasmodial without language restriction. Among the reported compounds, 51 selected ones displayed significant antiplasmodial potency with IC50 values lower than 10 μM against P. falciparum strains sensitive or resistant to chloroquine. For instance, ganoderic acid AW1 demonstrated a strong antiplasmodial activity with IC50 of 257.8 nM against P. falciparum D6, while strong activities were displayed by ganoweberianones A (IC50 = 0.050 μM) and B (IC50 = 0.46 μM) against P. falciparum K1. Moreover, some mushroom methanol extracts demonstrated good larvicidal and ovicidal activities against Anopheles stephensis. This paper provides further insights into the development of new antiplasmodial drugs or new potent eco-friendly pesticides to control mosquito vectors.","PeriodicalId":394827,"journal":{"name":"Natural Resources for Human Health","volume":"222 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132753914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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