Particuology最新文献

英文中文

Diffusive smoothing CFD-DEM simulations with particle-scale mass transfer in LBE solid-phase oxygen control systems

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL

Particuology

Pub Date : 2025-03-07 DOI: 10.1016/j.partic.2025.02.019

Yuqi Zhu , Hao Wu , Fang Liu , Yang Liu , Fenglei Niu , Jiyuan Tu

The coupled CFD-DEM simulations are widely recognized as a powerful approach for analyzing various particle-fluid systems. In lead-bismuth nuclear reactors, the liquid lead-bismuth eutectic (LBE) alloy is employed as the coolant, and the solid-phase oxygen control is a key technique for corrosion mitigation. In this work, diffusive smoothing CFD-DEM simulations are performed to investigate the particle-scale mass transfer behaviors of LBE solid-phase oxygen control loops. The dissolution of the lead oxide particle within the mass exchanger serves as the source term of the mass transfer processes. In the current model, the fluid flow, particle motion, particle-fluid interaction forces, and the mass transfer of oxygen concentration in LBE are incorporated in the governing equations. When the CFD cell size is smaller than the particle diameter, the diffusive smoothing method is proposed to calculate the void fraction field. Compared with the experimental results, the numerical simulations give a satisfactory prediction of the flow dynamics and particle-scale mass transfer. In the small-sized experiment, the total dissolution rate is about 0.0031 g/h at 380 °C, and it is notably lower than the oxygen consumption in a full-scale megawatt-level lead-bismuth reactor. A large-scale mass exchanger is designed, and the numerical simulations indicate that the oxygen control system achieves a dissolution rate ranging from 5.28 to 23.74 g/h at temperatures of 380–420 °C. It is sufficient to meet the expected oxygen consumption of 4.5 g/h in the nuclear reactor. The diffusive smoothing CFD-DEM approach provides a robust tool for the design and optimization of oxygen control loops of advanced lead-bismuth fast nuclear reactors.

{"title":"Diffusive smoothing CFD-DEM simulations with particle-scale mass transfer in LBE solid-phase oxygen control systems","authors":"Yuqi Zhu , Hao Wu , Fang Liu , Yang Liu , Fenglei Niu , Jiyuan Tu","doi":"10.1016/j.partic.2025.02.019","DOIUrl":"10.1016/j.partic.2025.02.019","url":null,"abstract":"<div><div>The coupled CFD-DEM simulations are widely recognized as a powerful approach for analyzing various particle-fluid systems. In lead-bismuth nuclear reactors, the liquid lead-bismuth eutectic (LBE) alloy is employed as the coolant, and the solid-phase oxygen control is a key technique for corrosion mitigation. In this work, diffusive smoothing CFD-DEM simulations are performed to investigate the particle-scale mass transfer behaviors of LBE solid-phase oxygen control loops. The dissolution of the lead oxide particle within the mass exchanger serves as the source term of the mass transfer processes. In the current model, the fluid flow, particle motion, particle-fluid interaction forces, and the mass transfer of oxygen concentration in LBE are incorporated in the governing equations. When the CFD cell size is smaller than the particle diameter, the diffusive smoothing method is proposed to calculate the void fraction field. Compared with the experimental results, the numerical simulations give a satisfactory prediction of the flow dynamics and particle-scale mass transfer. In the small-sized experiment, the total dissolution rate is about 0.0031 g/h at 380 °C, and it is notably lower than the oxygen consumption in a full-scale megawatt-level lead-bismuth reactor. A large-scale mass exchanger is designed, and the numerical simulations indicate that the oxygen control system achieves a dissolution rate ranging from 5.28 to 23.74 g/h at temperatures of 380–420 °C. It is sufficient to meet the expected oxygen consumption of 4.5 g/h in the nuclear reactor. The diffusive smoothing CFD-DEM approach provides a robust tool for the design and optimization of oxygen control loops of advanced lead-bismuth fast nuclear reactors.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"99 ","pages":"Pages 150-161"},"PeriodicalIF":4.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143610914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantify the edge effect of HPGR mills with DEM modelling 利用 DEM 建模量化 HPGR 磨机的边缘效应

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL

Particuology

Pub Date : 2025-03-05 DOI: 10.1016/j.partic.2025.02.013

Chengwei Zhang , Yudong Zou , Guojian Cheng , David Liu , Runyu Yang , Aibing Yu

High pressure grinding rolls (HPGR) mills are an energy efficient comminution device widely used in the cement and mineral processing industries. Uneven roll wear and particle breakage near edges causes significant variation in grinding pressure along the axial direction. This study aimed to quantify the edge effect on mill performance through discrete element method (DEM) modelling. The DEM model, coupled with a multi-body dynamics (MBD) model for the motion of the floating roll and a particle fracture model, was calibrated and validated by the experimental data from a lab-scale HPGR mill. The simulations showed that the edge effect had the most significant impact on particle-particle compressive force and product size (characterised by the median particle size d₅₀), followed by particle-roll force, and the least on throughput. Increasing roll length amplified the edge effect, causing larger variations in throughput, particle-roll force, and product size, while increasing roll size mitigated the edge effect, resulting in a more uniform product sizes and particle-wall interaction. On the other hand, varying grinding pressure had a minimal impact on the edge effect. A unified equation was proposed to quantify changes from parabolic to trapezoidal profiles. The proposed unified equation offers a new approach to predict changes in the wear and particle size profiles.

{"title":"Quantify the edge effect of HPGR mills with DEM modelling","authors":"Chengwei Zhang , Yudong Zou , Guojian Cheng , David Liu , Runyu Yang , Aibing Yu","doi":"10.1016/j.partic.2025.02.013","DOIUrl":"10.1016/j.partic.2025.02.013","url":null,"abstract":"<div><div>High pressure grinding rolls (HPGR) mills are an energy efficient comminution device widely used in the cement and mineral processing industries. Uneven roll wear and particle breakage near edges causes significant variation in grinding pressure along the axial direction. This study aimed to quantify the edge effect on mill performance through discrete element method (DEM) modelling. The DEM model, coupled with a multi-body dynamics (MBD) model for the motion of the floating roll and a particle fracture model, was calibrated and validated by the experimental data from a lab-scale HPGR mill. The simulations showed that the edge effect had the most significant impact on particle-particle compressive force and product size (characterised by the median particle size <em>d</em><sub>50</sub>), followed by particle-roll force, and the least on throughput. Increasing roll length amplified the edge effect, causing larger variations in throughput, particle-roll force, and product size, while increasing roll size mitigated the edge effect, resulting in a more uniform product sizes and particle-wall interaction. On the other hand, varying grinding pressure had a minimal impact on the edge effect. A unified equation was proposed to quantify changes from parabolic to trapezoidal profiles. The proposed unified equation offers a new approach to predict changes in the wear and particle size profiles.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"99 ","pages":"Pages 60-68"},"PeriodicalIF":4.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering nanodiamond platform for tumor light up and high-performance cancer treatment

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL

Particuology

Pub Date : 2025-03-05 DOI: 10.1016/j.partic.2025.02.018

Hui Qiao , Jiangtao Wu , Dongmei Zhang , Jicheng Cui , Wenxia Zhang , Yingqi Li

Many small molecule chemotherapy drugs suffer from the disadvantages of poor water solubility, tumor off-target and resistance to chemotherapeutics, resulting in severe toxic side effects. Herein, a folic acid-targeted nanodiamond drug delivery system (NPF/D) was fabricated. The fluorescence of doxorubicin (DOX) is quenched when DOX is immobilized on the nanodiamond (ND) through disulfide bonds, which can be broken by overexpressed endogenous glutathione (GSH) within tumor cells to lead to drug release and GSH depletion, thereby selectively killing cancer cells instead of normal cells and increasing cancer cells sensitivity to chemotherapy drugs. In addition, the NPF/D system can overcome drug efflux and improve the efficacy of chemotherapy against drug resistance. It was of great importance that NPF/D effectively accumulated at the tumor site and significantly inhibited tumor growth, where the tumor volume was reduced by about 3 times compared to the control group. Interestingly, the combination of NPF/D with Toll-like receptor 7 agonist imiquimod (R837) and programmed cell death ligand 1 antibody (anti-PD-L1) markedly inhibited distant tumor growth, indicating good immune response. Therefore, such a nanodiamond nanoplatform with the integration of various functions has successfully demonstrated its promise for safe and efficient cancer treatment.

{"title":"Engineering nanodiamond platform for tumor light up and high-performance cancer treatment","authors":"Hui Qiao , Jiangtao Wu , Dongmei Zhang , Jicheng Cui , Wenxia Zhang , Yingqi Li","doi":"10.1016/j.partic.2025.02.018","DOIUrl":"10.1016/j.partic.2025.02.018","url":null,"abstract":"<div><div>Many small molecule chemotherapy drugs suffer from the disadvantages of poor water solubility, tumor off-target and resistance to chemotherapeutics, resulting in severe toxic side effects. Herein, a folic acid-targeted nanodiamond drug delivery system (NPF/D) was fabricated. The fluorescence of doxorubicin (DOX) is quenched when DOX is immobilized on the nanodiamond (ND) through disulfide bonds, which can be broken by overexpressed endogenous glutathione (GSH) within tumor cells to lead to drug release and GSH depletion, thereby selectively killing cancer cells instead of normal cells and increasing cancer cells sensitivity to chemotherapy drugs. In addition, the NPF/D system can overcome drug efflux and improve the efficacy of chemotherapy against drug resistance. It was of great importance that NPF/D effectively accumulated at the tumor site and significantly inhibited tumor growth, where the tumor volume was reduced by about 3 times compared to the control group. Interestingly, the combination of NPF/D with Toll-like receptor 7 agonist imiquimod (R837) and programmed cell death ligand 1 antibody (<em>anti</em>-PD-L1) markedly inhibited distant tumor growth, indicating good immune response. Therefore, such a nanodiamond nanoplatform with the integration of various functions has successfully demonstrated its promise for safe and efficient cancer treatment.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"99 ","pages":"Pages 162-172"},"PeriodicalIF":4.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Well-construction of hollow-pocket shaped Zn-based metal-organic framework for boosting the capture ability towards thiophene sulfur

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL

Particuology

Pub Date : 2025-03-05 DOI: 10.1016/j.partic.2025.02.017

Qiaolan Yu , Tingting Zhan , Zhouheng Xia , Gaojie Lu , Na Ma , Wei Dai

Conventional metal-organic frameworks (MOFs) have potential applications in adsorption desulfurization due to their open metal sites, structural diversity, and high specific surface area. However, the narrow internal pores limit the adsorption and diffusion of thiophene sulfur molecules (TSM). Therefore, we constructed a novel hollow-type Zn-BTC (HZB) adsorbent by a self-assembled hydrothermal method without using dopant templating agents. The presence of a large internal cavity can be seen by SEM. The results of batch tests showed that the hollow structure Zn-BTC has higher sulfur absorption capacity and faster diffusion rate. The adsorption isotherms were in good agreement with both Freundlich and Dubinin-Radushkevich (D-R) models, suggesting multilayer adsorption combined with pore-filling effect. The maximum adsorption capacity of the TSMs could reach 80% within 30 min, which enabled rapid adsorption in accordance with the pseudo-second-order kinetic model. The adsorption mechanism involves pore filling, ligand effect, and π-π attraction. In addition, HZB-3 maintained good adsorption capacity after the fifth cycle, showing good reusability and stability. This work provides a new strategy for TMS capture using hollow MOF.

{"title":"Well-construction of hollow-pocket shaped Zn-based metal-organic framework for boosting the capture ability towards thiophene sulfur","authors":"Qiaolan Yu , Tingting Zhan , Zhouheng Xia , Gaojie Lu , Na Ma , Wei Dai","doi":"10.1016/j.partic.2025.02.017","DOIUrl":"10.1016/j.partic.2025.02.017","url":null,"abstract":"<div><div>Conventional metal-organic frameworks (MOFs) have potential applications in adsorption desulfurization due to their open metal sites, structural diversity, and high specific surface area. However, the narrow internal pores limit the adsorption and diffusion of thiophene sulfur molecules (TSM). Therefore, we constructed a novel hollow-type Zn-BTC (HZB) adsorbent by a self-assembled hydrothermal method without using dopant templating agents. The presence of a large internal cavity can be seen by SEM. The results of batch tests showed that the hollow structure Zn-BTC has higher sulfur absorption capacity and faster diffusion rate. The adsorption isotherms were in good agreement with both Freundlich and Dubinin-Radushkevich (D-R) models, suggesting multilayer adsorption combined with pore-filling effect. The maximum adsorption capacity of the TSMs could reach 80% within 30 min, which enabled rapid adsorption in accordance with the pseudo-second-order kinetic model. The adsorption mechanism involves pore filling, ligand effect, and π-π attraction. In addition, HZB-3 maintained good adsorption capacity after the fifth cycle, showing good reusability and stability. This work provides a new strategy for TMS capture using hollow MOF.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"99 ","pages":"Pages 116-127"},"PeriodicalIF":4.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluidization of wet cohesive powder in virtual Couette rheometer

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL

Particuology

Pub Date : 2025-03-05 DOI: 10.1016/j.partic.2025.02.015

Sudeshna Roy

A virtual Couette rheometer is used to study the behavior of dry and wet granular materials in an aerated bed. A typical fluidization curve for dry powders exhibits fixed bed characterized by linear increase in pressure drop with increasing air velocity. This is followed by a fluidized bed at a constant pressure drop with further increase in air velocity. However, wet powders display different aeration behaviour due to the inhomogeneous gas flow through the bed. The fluidization behaviour of the powder upon addition of small amounts of silicon oil liquid has been tested for two different grain sizes. Different fluidization regimes are identified for wet powders with varying silicon oil saturations and grain sizes. Additionally, hysteresis effects in the fluidization and de-fluidization cycles of the materials are compared. The shear stresses and rheology of the materials under different fluidization conditions are also analyzed.

引用次数: 0

Effect of particle behavior on the apparent viscosity of semi-solid metal: CFD-DEM simulation and artificial neural networks prediction

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL

Particuology

Pub Date : 2025-03-04 DOI: 10.1016/j.partic.2025.02.014

Dianqiao Geng , Dandan Yan , Wenjie Yu , Jie Liang , Ping Wang

Accurate prediction of apparent viscosity and analyzing the influence mechanism of particle behavior on apparent viscosity is of great importance for the semi-solid processing process. In this paper, the coupled CFD-DEM method is employed to study the solid-liquid two phase flow and particle behavior in semi-solid aluminum. The artificial neural networks method is used to predict the lubrication force range and calculate the apparent viscosity of semi-solid aluminum. The results show that the increasing shear rate results in the increasing coordination number of clusters, indicating that the spherical evolution of clusters caused by shear is important reason for the shear thinning of semi-solid metal. The blockage caused by the large cluster formed under high solid volume fraction leads in the high apparent viscosity. Predicting the apparent viscosity of semi-solid metal must consider the particle agglomeration behavior. Based on artificial neural networks method, the apparent viscosity of semi-solid metal can be estimated accurately by predicting the lubrication force range under different solid volume fractions and shear conditions.

{"title":"Effect of particle behavior on the apparent viscosity of semi-solid metal: CFD-DEM simulation and artificial neural networks prediction","authors":"Dianqiao Geng , Dandan Yan , Wenjie Yu , Jie Liang , Ping Wang","doi":"10.1016/j.partic.2025.02.014","DOIUrl":"10.1016/j.partic.2025.02.014","url":null,"abstract":"<div><div>Accurate prediction of apparent viscosity and analyzing the influence mechanism of particle behavior on apparent viscosity is of great importance for the semi-solid processing process. In this paper, the coupled CFD-DEM method is employed to study the solid-liquid two phase flow and particle behavior in semi-solid aluminum. The artificial neural networks method is used to predict the lubrication force range and calculate the apparent viscosity of semi-solid aluminum. The results show that the increasing shear rate results in the increasing coordination number of clusters, indicating that the spherical evolution of clusters caused by shear is important reason for the shear thinning of semi-solid metal. The blockage caused by the large cluster formed under high solid volume fraction leads in the high apparent viscosity. Predicting the apparent viscosity of semi-solid metal must consider the particle agglomeration behavior. Based on artificial neural networks method, the apparent viscosity of semi-solid metal can be estimated accurately by predicting the lubrication force range under different solid volume fractions and shear conditions.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"99 ","pages":"Pages 184-193"},"PeriodicalIF":4.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of colon-targeted alginate microspheres loaded with the honokiol-doxorubicin conjugate and their therapeutic effect on colon cancer

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL

Particuology

Pub Date : 2025-03-04 DOI: 10.1016/j.partic.2025.02.016

Limei Zhang , Huatai Zhu , Peng Ye , Yuting Ren , Hongyu Wang , Jiandu Lei , Jing He

Combining drug delivery technologies with chemotherapeutic drugs is very attractive in terms of enhancing antitumor efficacy and reducing toxicity. Alginate microspheres stand out in the field of drug delivery due to their biocompatibility and high conversion rate. However, there are certain drawbacks in their preparation technology and further research is needed on how to prepare alginate microspheres with uniform particle size using high-viscosity sodium alginate solution. Therefore, this study proposed a novel microfluidic membrane emulsification technique for the preparation of alginate microspheres from high-viscosity sodium alginate solution. A tumor microenvironment-responsive colorectal cancer-targeted oral drug delivery system was constructed using a disulfide-bonded coupling of honokiol and doxorubicin as a model drug to achieve precise targeting, efficiency enhancement and toxicity reduction. The results showed that the prepared microspheres were relatively homogeneous in particle size. The in vitro model showed the high stability of the microspheres in the gastric acid environment and the colon-targeted release characteristic. And the system triggered the breakage of redox bonds and the precise release of the drug, showing good antitumor activity. This study contributes to the construction of drug delivery systems and the study of colon cancer treatment, which has a promising application.

{"title":"Preparation of colon-targeted alginate microspheres loaded with the honokiol-doxorubicin conjugate and their therapeutic effect on colon cancer","authors":"Limei Zhang , Huatai Zhu , Peng Ye , Yuting Ren , Hongyu Wang , Jiandu Lei , Jing He","doi":"10.1016/j.partic.2025.02.016","DOIUrl":"10.1016/j.partic.2025.02.016","url":null,"abstract":"<div><div>Combining drug delivery technologies with chemotherapeutic drugs is very attractive in terms of enhancing antitumor efficacy and reducing toxicity. Alginate microspheres stand out in the field of drug delivery due to their biocompatibility and high conversion rate. However, there are certain drawbacks in their preparation technology and further research is needed on how to prepare alginate microspheres with uniform particle size using high-viscosity sodium alginate solution. Therefore, this study proposed a novel microfluidic membrane emulsification technique for the preparation of alginate microspheres from high-viscosity sodium alginate solution. A tumor microenvironment-responsive colorectal cancer-targeted oral drug delivery system was constructed using a disulfide-bonded coupling of honokiol and doxorubicin as a model drug to achieve precise targeting, efficiency enhancement and toxicity reduction. The results showed that the prepared microspheres were relatively homogeneous in particle size. The <em>in vitro</em> model showed the high stability of the microspheres in the gastric acid environment and the colon-targeted release characteristic. And the system triggered the breakage of redox bonds and the precise release of the drug, showing good antitumor activity. This study contributes to the construction of drug delivery systems and the study of colon cancer treatment, which has a promising application.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"99 ","pages":"Pages 69-79"},"PeriodicalIF":4.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the coupled reverse antisolvent-cooling crystallization of D-psicose intensified by magnetic field

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL

Particuology

Pub Date : 2025-03-03 DOI: 10.1016/j.partic.2025.02.010

Mengyao Wang , Wenxiu Yang , Zhiyuan Zhao , Qi Hao , Xiong Yu , Honghai Wang , Weiyi Su

D-psicose is a rare sugar that has currently attracted more attention for its unique functionality and medical potential. It is mainly obtained by converting fructose through DTE or DPE, followed by purification and crystallization steps. In this study, an innovative coupled reverse antisolvent-cooling crystallization process was developed to produce D-psicose with high yield and reasonable crystal size. Specifically, the usage of antisolvent ethanol decreased the viscosity of the whole system, which somehow improved the mass transfer process, while the cooling process ensured the high yield since the solubility of D-psicose was found to drop with temperature. During the study, the coupled process was optimized through response surface methodology, and the yield of 84% was obtained. With the precise regulation to supersaturation, the crystal size was enlarged to 266 μm, which was suitable for downstream filtration, drying etc. To further intensify the industrial productivity, a magnetic field was used throughout to intensify the crystallization process, with which the total crystallization duration was shortened to 50 h from common 70–195 h. It is believable that the new coupled reverse antisolvent-cooling crystallization was advantageous to efficiently produce D-psicose with high quality.

{"title":"Study on the coupled reverse antisolvent-cooling crystallization of D-psicose intensified by magnetic field","authors":"Mengyao Wang , Wenxiu Yang , Zhiyuan Zhao , Qi Hao , Xiong Yu , Honghai Wang , Weiyi Su","doi":"10.1016/j.partic.2025.02.010","DOIUrl":"10.1016/j.partic.2025.02.010","url":null,"abstract":"<div><div>D-psicose is a rare sugar that has currently attracted more attention for its unique functionality and medical potential. It is mainly obtained by converting fructose through DTE or DPE, followed by purification and crystallization steps. In this study, an innovative coupled reverse antisolvent-cooling crystallization process was developed to produce D-psicose with high yield and reasonable crystal size. Specifically, the usage of antisolvent ethanol decreased the viscosity of the whole system, which somehow improved the mass transfer process, while the cooling process ensured the high yield since the solubility of D-psicose was found to drop with temperature. During the study, the coupled process was optimized through response surface methodology, and the yield of 84% was obtained. With the precise regulation to supersaturation, the crystal size was enlarged to 266 μm, which was suitable for downstream filtration, drying etc. To further intensify the industrial productivity, a magnetic field was used throughout to intensify the crystallization process, with which the total crystallization duration was shortened to 50 h from common 70–195 h. It is believable that the new coupled reverse antisolvent-cooling crystallization was advantageous to efficiently produce D-psicose with high quality.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"99 ","pages":"Pages 34-46"},"PeriodicalIF":4.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Romanesco-like calcium carbonate hybrid nanoflowers via egg white lysosomal enzyme-assisted biomineralization

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL

Particuology

Pub Date : 2025-03-01 DOI: 10.1016/j.partic.2025.02.002

Chan Hee Lee , Kyung Chan Jeon , Ji Ho Min , Hyung Seo Hwang , Ee Taek Hwang

Bioinspired hybrid organic–inorganic nanoflowers can be significantly influenced by the inclusion of enzymes derived from cellular organelles, thus offering unique structural functions and applications. This study has introduced a novel approach using egg-white lysosomal enzymes (EWLEs) for the synthesis of Romanesco-like calcium carbonate (CaCO₃) hybrid nanoflowers, marking the first use of cellular organelle enzymes in this context. Our approach leveraged the intrinsic properties of EWLEs, leading to the formation of nanoflowers composed of calcite and vaterite polymorphs via biomimetic mineralization. These hybrid nanoflowers successfully incorporated 1.0 mg of EWLE, exhibited a specific peroxidase activity of approximately 0.0198 mM min⁻¹ mg⁻¹ and retained over 78% of their initial activity for more than 60 days, demonstrating exceptional stability. This work challenges traditional methods by emphasizing the dynamic, biomimetic transformation of enzyme-organic hybrid systems, and offers new insights into enzyme-material interactions. This bridges the gap between biomineralization and enzyme applications and opens innovative possibilities for stabilizing enzymes, enhancing catalytic efficiency, and developing advanced biomaterials for biocatalysis.

{"title":"Romanesco-like calcium carbonate hybrid nanoflowers via egg white lysosomal enzyme-assisted biomineralization","authors":"Chan Hee Lee , Kyung Chan Jeon , Ji Ho Min , Hyung Seo Hwang , Ee Taek Hwang","doi":"10.1016/j.partic.2025.02.002","DOIUrl":"10.1016/j.partic.2025.02.002","url":null,"abstract":"<div><div>Bioinspired hybrid organic–inorganic nanoflowers can be significantly influenced by the inclusion of enzymes derived from cellular organelles, thus offering unique structural functions and applications. This study has introduced a novel approach using egg-white lysosomal enzymes (EWLEs) for the synthesis of Romanesco-like calcium carbonate (CaCO<sub>3</sub>) hybrid nanoflowers, marking the first use of cellular organelle enzymes in this context. Our approach leveraged the intrinsic properties of EWLEs, leading to the formation of nanoflowers composed of calcite and vaterite polymorphs via biomimetic mineralization. These hybrid nanoflowers successfully incorporated 1.0 mg of EWLE, exhibited a specific peroxidase activity of approximately 0.0198 mM min<sup>−1</sup> mg<sup>−1</sup> and retained over 78% of their initial activity for more than 60 days, demonstrating exceptional stability. This work challenges traditional methods by emphasizing the dynamic, biomimetic transformation of enzyme-organic hybrid systems, and offers new insights into enzyme-material interactions. This bridges the gap between biomineralization and enzyme applications and opens innovative possibilities for stabilizing enzymes, enhancing catalytic efficiency, and developing advanced biomaterials for biocatalysis.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"98 ","pages":"Pages 265-270"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental study on flow behavior of wet elongated biomass particles and aggregation-fragmentation evolution of cluster system in a lifting tube

IF 4.1 2区材料科学 Q2 ENGINEERING, CHEMICAL

Particuology

Pub Date : 2025-03-01 DOI: 10.1016/j.partic.2025.02.004

Kaiyuan Deng , Conghui Gu , Jingyu Zhu , Mingpu Du , Danila Pliutenko

Biomass is a renewable energy source helps reduce greenhouse gas emissions. However, combustion and reaction efficiency of biomass are significantly affected by their flow behavior. In this study, the flow characteristics of wet elongated biomass particles in a lifting tube were experimentally investigated. Particle Tracking Velocimetry (PTV) was used to explore the particle area and velocity distribution under different gas-to-particle mass ratios (GPMR) and initial moisture contents (IMC). A homogeneity coefficient was also formulated to quantify the flow homogeneity of the particle population. The calculated range for the homogeneity coefficient α is 4.43–6.40, with smaller values indicating better flow homogeneity. Moreover, the factors affecting the fragmentation of larger particle clusters were analyzed with respect to the suspension process, the process of being carried out by the airflow, and the fragmentation process. The results indicated that the flow homogeneity of the particle population was better in the two sets of conditions when IMC was 28.7% and GPMR was 10 and when IMC was 32.5% and GPMR was 9. The homogeneity coefficient α was 4.43 and 4.79. In addition, the degree of fragmentation of larger particle clusters is mainly affected by the IMC.

{"title":"Experimental study on flow behavior of wet elongated biomass particles and aggregation-fragmentation evolution of cluster system in a lifting tube","authors":"Kaiyuan Deng , Conghui Gu , Jingyu Zhu , Mingpu Du , Danila Pliutenko","doi":"10.1016/j.partic.2025.02.004","DOIUrl":"10.1016/j.partic.2025.02.004","url":null,"abstract":"<div><div>Biomass is a renewable energy source helps reduce greenhouse gas emissions. However, combustion and reaction efficiency of biomass are significantly affected by their flow behavior. In this study, the flow characteristics of wet elongated biomass particles in a lifting tube were experimentally investigated. Particle Tracking Velocimetry (PTV) was used to explore the particle area and velocity distribution under different gas-to-particle mass ratios (GPMR) and initial moisture contents (IMC). A homogeneity coefficient was also formulated to quantify the flow homogeneity of the particle population. The calculated range for the homogeneity coefficient <em>α</em> is 4.43–6.40, with smaller values indicating better flow homogeneity. Moreover, the factors affecting the fragmentation of larger particle clusters were analyzed with respect to the suspension process, the process of being carried out by the airflow, and the fragmentation process. The results indicated that the flow homogeneity of the particle population was better in the two sets of conditions when IMC was 28.7% and GPMR was 10 and when IMC was 32.5% and GPMR was 9. The homogeneity coefficient <em>α</em> was 4.43 and 4.79. In addition, the degree of fragmentation of larger particle clusters is mainly affected by the IMC.</div></div>","PeriodicalId":401,"journal":{"name":"Particuology","volume":"98 ","pages":"Pages 249-264"},"PeriodicalIF":4.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Particuology

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀