La disminucion de la mortalidad por Cancer de Mama, demostrada en algunos paises del mundo, se ha conseguido gracias a la administracion de tratamientos oportunos e integrales y posiblemente a una estrategia de tamizacion formal que incluya a la mamografia como eje principal. La funcion principal de la mamografia de tamizacion es el diagnostico temprano de la enfermedad para lograr reducir la mortalidad por esta causa. La implementacion de estrategias de deteccion temprana en cancer de mama, en Colombia, intenta ejecutarse bajo importantes limitaciones y logisticas de nuestro sistema de salud. Estas estrategias se han venido construyendo de la mano de centros de tratamiento oncologico integral como el INC, asociaciones cientificas y la experiencia de cientos de medicos especialistas en el manejo de dicha enfermedad.
{"title":"Retos para el control del cáncer en Colombia: ante todo más acción.","authors":"L. Gonzalez","doi":"10.35509/01239015.712","DOIUrl":"https://doi.org/10.35509/01239015.712","url":null,"abstract":"La disminucion de la mortalidad por Cancer de Mama, demostrada en algunos paises del mundo, se ha conseguido gracias a la administracion de tratamientos oportunos e integrales y posiblemente a una estrategia de tamizacion formal que incluya a la mamografia como eje principal. La funcion principal de la mamografia de tamizacion es el diagnostico temprano de la enfermedad para lograr reducir la mortalidad por esta causa. \u0000La implementacion de estrategias de deteccion temprana en cancer de mama, en Colombia, intenta ejecutarse bajo importantes limitaciones y logisticas de nuestro sistema de salud. Estas estrategias se han venido construyendo de la mano de centros de tratamiento oncologico integral como el INC, asociaciones cientificas y la experiencia de cientos de medicos especialistas en el manejo de dicha enfermedad.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48398806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Handerson Rafael Osma Charris, Fernando Contreras Mejía, Camilo Vallejo Yepes, Carolina Bautista Saiz, Vilma Medina Boada, Tatiana Roncancio Velandia
Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignant neoplastic disease. It predominantly affects men between the second and third decades of life. Patients with it have a poor prognosis, with a 5-year survival of up to 30%. It generally presents as a mass in the abdominal cavity, often multifocal. A multimodal approach is recommended for its treatment, with surgery, chemotherapy and radiotherapy. Just over 20 cases of testicular/paratesticular DSRCT have been reported in the literature. Next, we present an illustrative case in this location, the case is discussed and a review of the literature is carried out.
{"title":"Tumor desmoplásico de célula pequeña y redonda paratesticular/testicular: reporte de caso y revisión de la literatura.","authors":"Handerson Rafael Osma Charris, Fernando Contreras Mejía, Camilo Vallejo Yepes, Carolina Bautista Saiz, Vilma Medina Boada, Tatiana Roncancio Velandia","doi":"10.35509/01239015.691","DOIUrl":"https://doi.org/10.35509/01239015.691","url":null,"abstract":"Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignant neoplastic disease. It predominantly affects men between the second and third decades of life. Patients with it have a poor prognosis, with a 5-year survival of up to 30%. It generally presents as a mass in the abdominal cavity, often multifocal. A multimodal approach is recommended for its treatment, with surgery, chemotherapy and radiotherapy. Just over 20 cases of testicular/paratesticular DSRCT have been reported in the literature. Next, we present an illustrative case in this location, the case is discussed and a review of the literature is carried out.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47965039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Alejandra Baquero Serrano, Luis Andrés López Martínez, Silvia Nathalia Vera Campos, Sergio Andrés Rosales Rueda, Natalia Jaramillo Botero, Miguel Ochoa Vera
Introduction: The presence of dense breast tissue in women is a condition that makes it difficult to assess and adequately interpret mammography, possibly masking suspicious lesions of malignancy. Recent studies suggest the performance of complementary studies for the screening and diagnostic approach of these patients. Objective: To establish the prevalence of women over 50 with dense breasts in Bucaramanga city studied by mammography and evaluate the performance of complementary studies Materials and methods: A retrospective descriptive study was conducted during the period from January 1, 2014 to August 31, 2015, 10,110 mammograms were reviewed in patients over 50 years of age. Subsequently, a review of the literature in the main databases was made. Results: 10110 mammograms were performed, 4448 were found to be positive for dense breast. 39.69% was heterogeneously dense breast tissue, and 4.29% extremely dense; The result was 43.9% patients with positive dense breasts Discussion: Breast density is an independent risk factor for breast cancer, being of medium importance compared to other factors. As the breast density increases, the overlap of the radiopaque breast tissue that can hide and delay the diagnosis of an underlying cancer is generated Conclusion: Given the high prevalence of dense breast tissue found in our population, current evidence suggests complementing screening with other imaging methods, individualizing each patient.
{"title":"Prevalencia de tejido mamario denso en una población en la ciudad de Bucaramanga, Colombia","authors":"María Alejandra Baquero Serrano, Luis Andrés López Martínez, Silvia Nathalia Vera Campos, Sergio Andrés Rosales Rueda, Natalia Jaramillo Botero, Miguel Ochoa Vera","doi":"10.35509/01239015.94","DOIUrl":"https://doi.org/10.35509/01239015.94","url":null,"abstract":"Introduction: The presence of dense breast tissue in women is a condition that makes it difficult to assess and adequately interpret mammography, possibly masking suspicious lesions of malignancy. Recent studies suggest the performance of complementary studies for the screening and diagnostic approach of these patients. \u0000Objective: To establish the prevalence of women over 50 with dense breasts in Bucaramanga city studied by mammography and evaluate the performance of complementary studies \u0000Materials and methods: A retrospective descriptive study was conducted during the period from January 1, 2014 to August 31, 2015, 10,110 mammograms were reviewed in patients over 50 years of age. Subsequently, a review of the literature in the main databases was made. \u0000Results: 10110 mammograms were performed, 4448 were found to be positive for dense breast. 39.69% was heterogeneously dense breast tissue, and 4.29% extremely dense; The result was 43.9% patients with positive dense breasts \u0000Discussion: Breast density is an independent risk factor for breast cancer, being of medium importance compared to other factors. As the breast density increases, the overlap of the radiopaque breast tissue that can hide and delay the diagnosis of an underlying cancer is generated \u0000Conclusion: Given the high prevalence of dense breast tissue found in our population, current evidence suggests complementing screening with other imaging methods, individualizing each patient.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43108434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ricardo Sánchez Pedraza, Ricardo Alfonso Merchán-Chaverra, María Carolina Castro-Muñoz, M. R. Gamba-Rincón, Martha Patricia Rojas-Hurtado, Cielo Almenares-Campo
Objetivo: Realizar la traducción y adaptación transcultural del componente de síntomas gastrointestinales (SGI) de la escala CTCAE Versión 4.02, en pacientes ambulatorios tratados con quimioterapia en el Instituto Nacional de Cancerología en Bogotá. Métodos: Se realizó una búsqueda manual en medios electrónicos, de escalas en idiomas inglés o español, que evaluarán la presencia, frecuencia o intensidad de SGI en pacientes oncológicos. La selección de los ítems fue efectuada por consenso informal de un comité técnico, que verificó la concordancia entre los principales SGI descritos en la literatura y los incluidos en la escala, todos los cuales podrían afectar el estado nutricional. Para la adaptación transcultural se siguieron los pasos y recomendaciones del manual ISPOR y del grupo de calidad de vida EORTC. La prueba piloto se efectuó en 25 pacientes seleccionados por conveniencia, que cumplieron los criterios de inclusión. Resultados: El 52% fueron hombres; la edad promedio fue 54,2 años (+/- 15,3 años). Los cánceres más frecuentes fueron: colorrectal (28%), estómago (16%) y mama (12%). Los 14 SGI incluidos en la escala fueron experimentados por todos los pacientes, por lo cual se conservaron, y no se requirió adicionar ningún otro. El tiempo promedio de aplicación del instrumento fue de 5 minutos y el 90% de los participantes lo consideró adecuado. Conclusiones: Se generó un instrumento de 14 ítems para medir SGI en pacientes oncológicos ambulatorios sometidos a quimioterapia, que es de rápida aplicación y utiliza lenguaje de fácil comprensión para el paciente. Quedan por definir sus propiedades clinimétricas.
{"title":"Adaptación transcultural del componente de síntomas gastrointestinales de la escala CTCAE versión 4.02","authors":"Ricardo Sánchez Pedraza, Ricardo Alfonso Merchán-Chaverra, María Carolina Castro-Muñoz, M. R. Gamba-Rincón, Martha Patricia Rojas-Hurtado, Cielo Almenares-Campo","doi":"10.35509/01239015.51","DOIUrl":"https://doi.org/10.35509/01239015.51","url":null,"abstract":"Objetivo: Realizar la traducción y adaptación transcultural del componente de síntomas gastrointestinales (SGI) de la escala CTCAE Versión 4.02, en pacientes ambulatorios tratados con quimioterapia en el Instituto Nacional de Cancerología en Bogotá. \u0000Métodos: Se realizó una búsqueda manual en medios electrónicos, de escalas en idiomas inglés o español, que evaluarán la presencia, frecuencia o intensidad de SGI en pacientes oncológicos. La selección de los ítems fue efectuada por consenso informal de un comité técnico, que verificó la concordancia entre los principales SGI descritos en la literatura y los incluidos en la escala, todos los cuales podrían afectar el estado nutricional. Para la adaptación transcultural se siguieron los pasos y recomendaciones del manual ISPOR y del grupo de calidad de vida EORTC. La prueba piloto se efectuó en 25 pacientes seleccionados por conveniencia, que cumplieron los criterios de inclusión. \u0000Resultados: El 52% fueron hombres; la edad promedio fue 54,2 años (+/- 15,3 años). Los cánceres más frecuentes fueron: colorrectal (28%), estómago (16%) y mama (12%). Los 14 SGI incluidos en la escala fueron experimentados por todos los pacientes, por lo cual se conservaron, y no se requirió adicionar ningún otro. El tiempo promedio de aplicación del instrumento fue de 5 minutos y el 90% de los participantes lo consideró adecuado. \u0000Conclusiones: Se generó un instrumento de 14 ítems para medir SGI en pacientes oncológicos ambulatorios sometidos a quimioterapia, que es de rápida aplicación y utiliza lenguaje de fácil comprensión para el paciente. Quedan por definir sus propiedades clinimétricas.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43944799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
La supervivencia global y la calidad de vida son objetivos primarios del tratamiento del cáncer. El desarrollo de terapias blanco promovió el concepto de tratamientos personalizados, los que se han evaluado principalmente mediante desenlaces centrados en el tumor y han tenido foco en tumores de baja frecuencia y estados avanzados. La inmunoterapia rompe esta tendencia y genera expectativa por su efecto en la supervivencia global y su potencial uso en una gama amplia de tumores. Dentro de esta, las vacunas basadas en neoantígenos han mostrado alta eficacia y seguridad debido a su afinidad con células T y su elevada especificidad. Basado en sus principios biológicos se revisa su posible impacto en la carga de enfermedad según la relación entre potencial inmunogénico y prevalencia por tipo de tumor, el posible efecto en la práctica clínica por su combinación con otras modalidades de tratamiento, y el efecto en el acceso al tratamiento dado su proceso de desarrollo y producción y la disponibilidad de información propia.
{"title":"Vacunas basadas en neoantígenos y control del cáncer: perspectivas","authors":"Raúl Hernando Murillo Moreno","doi":"10.35509/01239015.195","DOIUrl":"https://doi.org/10.35509/01239015.195","url":null,"abstract":"La supervivencia global y la calidad de vida son objetivos primarios del tratamiento del cáncer. El desarrollo de terapias blanco promovió el concepto de tratamientos personalizados, los que se han evaluado principalmente mediante desenlaces centrados en el tumor y han tenido foco en tumores de baja frecuencia y estados avanzados. La inmunoterapia rompe esta tendencia y genera expectativa por su efecto en la supervivencia global y su potencial uso en una gama amplia de tumores. Dentro de esta, las vacunas basadas en neoantígenos han mostrado alta eficacia y seguridad debido a su afinidad con células T y su elevada especificidad. Basado en sus principios biológicos se revisa su posible impacto en la carga de enfermedad según la relación entre potencial inmunogénico y prevalencia por tipo de tumor, el posible efecto en la práctica clínica por su combinación con otras modalidades de tratamiento, y el efecto en el acceso al tratamiento dado su proceso de desarrollo y producción y la disponibilidad de información propia.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45087089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carolina Wiesner-Ceballos, D. Puerto, Sandra Diaz-Casas, O. Sánchez, Raul Hernando-Murillo, L. Bravo
Colombia ranks at an intermediate risk leve/ regarding the development of breast cancer, with an age-standardized incidence rate of 44.1 per 100,000 women. Although mammography screening and annual Clinical Breast Examination for women aged 50 to 69 are recommended in Colombia, as well as early detection for symptomatic women regardless of age, mortality from this cause has not been reduced in Colombia. Multiple causes seem to explain this problem: low participation of the target population in mammography screening activities, poor quality of mammography, and access barriers for timely diagnosis and comprehensive treatment. In view of this problem, the House of Representatives approved in first debate last October 3 Bill no. 259 of 2019 "by means of which measures and other provisions for prevention, diagnosis, timely treatment, rehabilitation, and palliative care of breast cancer are set up". The Colombian Ilational Cancer Institute IIIC, held a forum on December 9, 2019, aimed at reviewing the scientific support of the content of the bill and contribute to its proper discussion. The purpose of this paper is to present the analysis of the most controversial points from a scientific perspective, as a basis for appropriate decision-making in public health policy.
{"title":"Políticas basadas en la evidencia científica: el caso del control del cáncer de mama en Colombia","authors":"Carolina Wiesner-Ceballos, D. Puerto, Sandra Diaz-Casas, O. Sánchez, Raul Hernando-Murillo, L. Bravo","doi":"10.35509/01239015.261","DOIUrl":"https://doi.org/10.35509/01239015.261","url":null,"abstract":"Colombia ranks at an intermediate risk leve/ regarding the development of breast cancer, with an age-standardized incidence rate of 44.1 per 100,000 women. Although mammography screening and annual Clinical Breast Examination for women aged 50 to 69 are recommended in Colombia, as well as early detection for symptomatic women regardless of age, mortality from this cause has not been reduced in Colombia. Multiple causes seem to explain this problem: low participation of the target population in mammography screening activities, poor quality of mammography, and access barriers for timely diagnosis and comprehensive treatment. In view of this problem, the House of Representatives approved in first debate last October 3 Bill no. 259 of 2019 \"by means of which measures and other provisions for prevention, diagnosis, timely treatment, rehabilitation, and palliative care of breast cancer are set up\". The Colombian Ilational Cancer Institute IIIC, held a forum on December 9, 2019, aimed at reviewing the scientific support of the content of the bill and contribute to its proper discussion. The purpose of this paper is to present the analysis of the most controversial points from a scientific perspective, as a basis for appropriate decision-making in public health policy.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2020-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43753518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patricia Cruz-Castellanos, L. Gutiérrez, D. Sánchez-Cabrero, F. Castro
Small cell lung cancer is a subtype of neoplasm that has typically been associated with smoking and is characterized by its aggressiveness and poor prognosis in the short term. As an entity it can metastasize in any organ, but pancreatic metastases are rare and most of the time asymptomatic. Therefore, the presence of neoplastic pancreatitis as in our case is exceptional and even more so when it presents refractoriness to conventional medical treatment, responding instead to systemic cytotoxic treatment. Therefore, we expose our clinical experience and discuss the presence of this rare entity and its management.
{"title":"Pancreatitis aguda en carcinoma de célula pequeña de pulmón (CPCP) resulta con quimioterapia","authors":"Patricia Cruz-Castellanos, L. Gutiérrez, D. Sánchez-Cabrero, F. Castro","doi":"10.35509/01239015.15","DOIUrl":"https://doi.org/10.35509/01239015.15","url":null,"abstract":"Small cell lung cancer is a subtype of neoplasm that has typically been associated with smoking and is characterized by its aggressiveness and poor prognosis in the short term. As an entity it can metastasize in any organ, but pancreatic metastases are rare and most of the time asymptomatic. Therefore, the presence of neoplastic pancreatitis as in our case is exceptional and even more so when it presents refractoriness to conventional medical treatment, responding instead to systemic cytotoxic treatment. Therefore, we expose our clinical experience and discuss the presence of this rare entity and its management.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":"24 1","pages":"88-91"},"PeriodicalIF":0.2,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42329993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: To validate the Colombian version of the EORTC QLQ-C30 questionnaire for measuring the quality of life in patients with cancer in Colombia. Methods: The validity of the questionnaire was evaluated using exploratory and confirmatory analyses. In addition, correlation between domains of EORTC QLQ-C30 and FACT-G was used to measure concurrent validity. For measuring reliability, internal consistency analyses (Cronbach Alpha, McDonald’s Omega and GLB coefficients) and repeated measures analyses were performed. Results: A total of 486 patients recruited at the National Cancer Institute (Instituto Nacional de Cancerologia), in Colombia, were included in the study. Both, the standard model (14 domains) and an empirical solution having 5 domains (Physical, Psychological, Weakness, Socioeconomic and Global Score) showed to be adequate for representing the construct. The correlation between domains of FACT-G and EORTC QLQ-C30 showed low values in the domains related with social functioning. The correlation between repeated measures had values of correlation-concordance between 0.51 and 0.8; the limits of agreement of Bland and Altman scored between -38 and 43 around an expected value of 0. The values of Cronbach’s Alpha, GLB and McDonald’s Omega had values of 0.94 – 0.96 and 0.93, respectively. Conclusion: The EORTC QLQ-C30 questionnaire is a valid and reliable tool for measuring the quality of life of patients with cancer in Colombia.
{"title":"Validación para utilización en Colombia de la escala EORTC QLQ C-30 para evaluación de la calidad de vida de los pacientes con cáncer","authors":"Ricardo Sánchez Pedraza, Adriana Valderamar","doi":"10.35509/01239015.128","DOIUrl":"https://doi.org/10.35509/01239015.128","url":null,"abstract":"Objective: To validate the Colombian version of the EORTC QLQ-C30 questionnaire for measuring the quality of life in patients with cancer in Colombia. \u0000Methods: The validity of the questionnaire was evaluated using exploratory and confirmatory analyses. In addition, correlation between domains of EORTC QLQ-C30 and FACT-G was used to measure concurrent validity. For measuring reliability, internal consistency analyses (Cronbach Alpha, McDonald’s Omega and GLB coefficients) and repeated measures analyses were performed. \u0000Results: A total of 486 patients recruited at the National Cancer Institute (Instituto Nacional de Cancerologia), in Colombia, were included in the study. Both, the standard model (14 domains) and an empirical solution having 5 domains (Physical, Psychological, Weakness, Socioeconomic and Global Score) showed to be adequate for representing the construct. The correlation between domains of FACT-G and EORTC QLQ-C30 showed low values in the domains related with social functioning. The correlation between repeated measures had values of correlation-concordance between 0.51 and 0.8; the limits of agreement of Bland and Altman scored between -38 and 43 around an expected value of 0. The values of Cronbach’s Alpha, GLB and McDonald’s Omega had values of 0.94 – 0.96 and 0.93, respectively. \u0000Conclusion: The EORTC QLQ-C30 questionnaire is a valid and reliable tool for measuring the quality of life of patients with cancer in Colombia.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":"24 1","pages":"61-71"},"PeriodicalIF":0.2,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47575803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amaranto Suarez Matos, Ingrid Aristizábal, Ana María Infante, C. Narváez, L. Barajas, M. Piña, G. Rincón, A. Calderón
Objective: Describe the demographic and clinical characteristics of patients with acute myeloid leukemia, and evaluate the mortality and survival of children treated with the LMA-INC 2004 protocol (modified from BFM 93) in our pediatric oncology clinic of the National Cancer Institute of Colombia between May 2002 and December 2014. Patients and methods: Retrospective descriptive observational study of a cohort with survival analysis of patients under 18 years of age with a diagnosis of acute myeloid leukemia treated with intensive chemotherapy without maintenance or transplantation. Results: We analyzed 41 patients diagnosed with myeloid leukemia except acute myeloid leukemia type M3, who were, treated with LMA-INC 2004 protocol. Complete remission was achieved in 75.6% of patients. The annual relapse rate was 27.4% and the death rate 20.3%. Cumulative overall survival at 2 and 5 years was 60% and 53.5%, respectively, with an average follow-up of 4.3 years (3.2 - 5.2 years); and the 5-year relapse-free survival was 42% with an average follow-up time of 3.5 years (3.3 - 4.6 years). Conclusion: The results showed a 30% improvement in the survival of patients with acute myeloid leukemia attributed to a more intense treatment that included the administration of high doses of cytarabine and mitoxantrone in consolidation and intensification; which implies improvement in supportive care.
{"title":"Mejoría en la supervivencia de los niños con leucemia mieloide aguda en el Instituto Nacional de Cancerología de Colombia","authors":"Amaranto Suarez Matos, Ingrid Aristizábal, Ana María Infante, C. Narváez, L. Barajas, M. Piña, G. Rincón, A. Calderón","doi":"10.35509/01239015.16","DOIUrl":"https://doi.org/10.35509/01239015.16","url":null,"abstract":"Objective: Describe the demographic and clinical characteristics of patients with acute myeloid leukemia, and evaluate the mortality and survival of children treated with the LMA-INC 2004 protocol (modified from BFM 93) in our pediatric oncology clinic of the National Cancer Institute of Colombia between May 2002 and December 2014. \u0000Patients and methods: Retrospective descriptive observational study of a cohort with survival analysis of patients under 18 years of age with a diagnosis of acute myeloid leukemia treated with intensive chemotherapy without maintenance or transplantation. \u0000Results: We analyzed 41 patients diagnosed with myeloid leukemia except acute myeloid leukemia type M3, who were, treated with LMA-INC 2004 protocol. Complete remission was achieved in 75.6% of patients. The annual relapse rate was 27.4% and the death rate 20.3%. Cumulative overall survival at 2 and 5 years was 60% and 53.5%, respectively, with an average follow-up of 4.3 years (3.2 - 5.2 years); and the 5-year relapse-free survival was 42% with an average follow-up time of 3.5 years (3.3 - 4.6 years). \u0000Conclusion: The results showed a 30% improvement in the survival of patients with acute myeloid leukemia attributed to a more intense treatment that included the administration of high doses of cytarabine and mitoxantrone in consolidation and intensification; which implies improvement in supportive care.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":"24 1","pages":"72-79"},"PeriodicalIF":0.2,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44372730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lipomatous Hypertrophy of the Interatrial Septum (LHIS) is a rare and benign cardiac entity that is characterized by the accumulation of adipose tissue within some segments of the interatrial septum. Patients are generally asymptomatic, and these lesions are discovered incidentally by imaging studies performed for other reasons, or in the context of an autopsy. In these patients, there have been described cases of sudden death due to disturbance of the heart rhythm. The differential diagnosis of LHIS mainly includes cardiac tumors. Here we present a case of a 61-year-old patient in whom, after a cardiac magnetic resonance study performed for an abnormal heart rhythm, it was documented a mass in the atrial septum. The patient was taken to surgery, and the histopathological study of the lesion confirmed the diagnosis. We conduct a review of the clinical and pathological characteristics of LHIS.
{"title":"Hipertrofia lipomatosa del septum interatrial: reporte de un caso","authors":"Fredy Rolando Salazar Heredia, P. López, J. Mejía","doi":"10.35509/01239015.347","DOIUrl":"https://doi.org/10.35509/01239015.347","url":null,"abstract":"Lipomatous Hypertrophy of the Interatrial Septum (LHIS) is a rare and benign cardiac entity that is characterized by the accumulation of adipose tissue within some segments of the interatrial septum. Patients are generally asymptomatic, and these lesions are discovered incidentally by imaging studies performed for other reasons, or in the context of an autopsy. In these patients, there have been described cases of sudden death due to disturbance of the heart rhythm. The differential diagnosis of LHIS mainly includes cardiac tumors. Here we present a case of a 61-year-old patient in whom, after a cardiac magnetic resonance study performed for an abnormal heart rhythm, it was documented a mass in the atrial septum. The patient was taken to surgery, and the histopathological study of the lesion confirmed the diagnosis. We conduct a review of the clinical and pathological characteristics of LHIS.","PeriodicalId":42496,"journal":{"name":"Revista Colombiana de Cancerologia","volume":"24 1","pages":"92-95"},"PeriodicalIF":0.2,"publicationDate":"2020-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49412564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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