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Recomendaciones para el cuidado de pacientes con cáncer y neoplasias hematológicas en el estado de pandemia COVID-19 en Colombia 哥伦比亚新型冠状病毒大流行状态下癌症和血液肿瘤患者护理建议
IF 0.2 Pub Date : 2020-11-30 DOI: 10.35509/01239015.701
Aylen Vanessa Ospina-Serrano, Virginia Abello-Polo, Orlando Bonell Patino-Escobar, Javier Ignacio Godoy-Barbosa, J. González, Henry Idrobo, Diego Emilio Lopera-Cortés, Humberto Martínez-Cordero, Mario Fernando Quintero-Ocaris, Javier Segovia-Gomez, C. A. Vargas-Baez, Andrés Yepes
IIn response to the Covid-19 pandemic, declared in March 2020 by the World Health Organization (WHO), the Colombian Association of Hematology and Oncology (ACHO) has been issuing communications aimed at providing guidance to health professionals involved in the treatment of hematological and oncological patients. Considering the pandemic mitigation phase we are currently facing, and the government’s approach to progressively tapering-off the quarantine, we deem it important to release a new update. These recommendations are not intended to impose a single conduct, since we understand that each case has particular characteristics and therefore it must be acted upon by individualizing each specific situation. The recommendations are based on documents issued by well-known cancer and hematological scientific associations, and are subject to change as  more information becomes available.
为应对世界卫生组织(世卫组织)于2020年3月宣布的Covid-19大流行,哥伦比亚血液学和肿瘤学协会(ACHO)一直在发布通信,旨在为参与血液学和肿瘤学患者治疗的卫生专业人员提供指导。考虑到目前面临的大流行缓解阶段,以及政府逐步减少隔离的方法,我们认为有必要发布新的更新。这些建议并不是要强加一种单一的行为,因为我们理解,每一种情况都有其特点,因此必须根据每一种具体情况采取具体行动。这些建议是基于著名的癌症和血液学科学协会发布的文件,随着更多信息的获得,这些建议可能会发生变化。
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引用次数: 2
La implementación de las vacunas basadas en neoantígenos tumorales: un desafío para la medicina de precisión en oncología 基于肿瘤新抗原的疫苗的实施:肿瘤精确医学的挑战
IF 0.2 Pub Date : 2020-11-26 DOI: 10.35509/01239015.713
C. P. López
En el año 2002 el grupo de Rosenberg en el Instituto Nacional de Cáncer en Estados Unidos demostró por primera vez que los linfocitos T pueden mediar regresiones tumorales notables, incluida la curación completa de pacientes con cáncer metastásico (1). Estos resultados logrados con la transferencia adoptiva de linfocitos T infiltrantes de tumor amplificados in vitro y luego restituidos al paciente, fue seguido de la implementación exitosa de terapias celulares con células CAR-T y el uso de anticuerpos anti-punto de control para el tratamiento de los tumores, con lo cual la Inmunoterapia junto a la Cirugía, la Quimioterapia y la Radioterapia se ha posicionado como el cuarto pilar de tratamiento del cáncer.
2002年,美国国家癌症研究所的罗森伯格小组首次证明,T淋巴细胞可以介导显著的肿瘤消退,包括转移性癌症患者的完全治愈(1)。这些结果是通过将体外扩增的肿瘤浸润性T淋巴细胞过继转移,然后将其恢复给患者,随后成功实施了CAR-T细胞的细胞疗法,并使用抗对照点抗体治疗肿瘤,从而将免疫疗法与手术、化疗和放疗结合起来,定位为癌症治疗的第四大支柱。
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引用次数: 0
Recomendaciones para el diagnóstico, tratamiento y seguimiento del cáncer de mama durante la pandemia de SARS-Cov-2/COVID-19 en Colombia 哥伦比亚SARS-CoV-2/Covid-19大流行期间乳腺癌诊断、治疗和监测建议
IF 0.2 Pub Date : 2020-11-19 DOI: 10.35509/01239015.687
Fernando Herazo Maya, Ricardo Brugés Maya, Ana Lucia Hincapie Uribe, Ana María Carvajal Barrera, Aylen Vanessa Ospina Serrano, Carlos Alberto Restrepo Ramirez, Carolina Benavides Duque, C. Alvarez, David Ignacio Gómez Duque, Jose Joaquin Caicedo Mallarino, Iván Andrés Bobadilla Arévalo, Jairo H. Patiño Pacheco, J. Cuello López, Johanna Paola Ibarra Palacio, John Jairo Sánchez Blando, Jorge Armando Egurrola Pedraza, Lina María Torres Vásquez, Luis Eduardo Viaña González, Luis Hernán Guzmán Abi-Saab, Luis José Palacios Fuenmayor, Luis Javier Gallon Villegas, Mauricio Lema Medina, Michel Hernández Restrepo, Natalia Jaramillo Botero, Néstor Llinás Quintero, Ray Manneh Kopp
The COVID-19 pandemic has given rise to an extraordinary and unprecedented crisis in health services, challenging the routine management of patients with breast disease. The main purpose of  the following recommendations is to determine temporary prioritization schemes in the care route of these patients throughout the COVID-19 pandemic in Colombia. These recommendations are aimed at medical personnel and other health professionals involved in managing patients with breast disease, and to oncological IPS and members of the General System for Social and Health Security in Colombia. The recommendations issued are based on those published by the American College of Surgeons (ACS), and were adapted by a group of experts from ACM (The Colombian Mastology Association) and AMA (the Antioquia Mastology Association)  with permission from the ACS. Adjustment suggestions were received from ACHO, ACRO and ACR representatives (Colombian Association of Hemato-Oncology - Colombian Association of Oncological Radiotherapy, and Colombian Association of Radiology, respectively). Three severity phases of the Covid-19 pandemic in the Colombian territory are proposed, along with recommendations for performing diagnostic images, outpatient consultation, surgery, systemic management, and radiotherapy, depending on the severity phases. These recommendations do not void or replace individual medical judgment, or national, regional, or institutional health policies. They aim to stimulate interdisciplinary approaches and adaptability and are subject to changes and updates according to new available evidence and the dynamic behavior of the pandemic.
新冠肺炎大流行在卫生服务领域引发了一场非同寻常、前所未有的危机,挑战了乳腺病患者的日常管理。以下建议的主要目的是在哥伦比亚新冠肺炎大流行期间,确定这些患者的护理路线中的临时优先计划。这些建议针对的是参与管理乳腺病患者的医务人员和其他卫生专业人员,以及肿瘤学IPS和哥伦比亚社会和卫生保障综合系统的成员。发布的建议基于美国外科医生学会(ACS)发布的建议,并由ACM(哥伦比亚乳房学协会)和AMA(安蒂奥基亚乳房学学会)的一组专家在获得ACS许可后进行了改编。ACHO、ACRO和ACR代表(分别为哥伦比亚血液肿瘤协会、哥伦比亚肿瘤放射治疗协会和哥伦比亚放射学协会)提出了调整建议。提出了哥伦比亚境内新冠肺炎大流行的三个严重程度阶段,以及根据严重程度阶段进行诊断图像、门诊咨询、手术、系统管理和放疗的建议。这些建议不会使个人的医疗判断或国家、地区或机构的健康政策无效或取而代之。它们旨在激发跨学科的方法和适应性,并根据新的可用证据和疫情的动态行为进行变化和更新。
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引用次数: 2
La biopsia líquida en el diagnóstico y monitoreo de pacientes oncológicos: oportunidades y retos en Latinoamérica 液体活检在肿瘤患者诊断和监测中的应用:拉丁美洲的机遇和挑战
IF 0.2 Pub Date : 2020-11-06 DOI: 10.35509/01239015.44
S. Perdomo, Lorena Montealegre-Páez, Rafael Adrián Pacheco-Orozco, Héctor Martínez-Gregorio, Felipe Vaca-Paniagua, J. Ardila, Federico Cayol, J. Oliver, C. Frecha, Javier Cuello López, David Carreño
ABSTRACT   In recent years, the study of circulating nucleic acids has made great progress in the field of oncology, allowing for significant advances in clinical applications of liquid biopsy in diverse areas such as prognosis, staging, recurrence prediction, selection and monitoring of treatments, among others. This advance is largely due to the development of new and better technologies, some of which have even been validated for the diagnosis and clinical follow-up of certain types of cancer. However, the use of liquid biopsy as an additional tool in clinical oncology remains under study. Given the worldwide importance of this technological advance, a literature review was conducted to establish the current status of the use of liquid biopsy in oncology, as well as its current clinical applications, with a particular focus on Latin America.
近年来,循环核酸的研究在肿瘤学领域取得了很大的进展,使得液体活检在预后、分期、复发预测、治疗方案的选择和监测等多个领域的临床应用取得了重大进展。这一进步主要是由于新的和更好的技术的发展,其中一些技术甚至已被证实用于某些类型癌症的诊断和临床随访。然而,液体活检作为临床肿瘤学的额外工具仍在研究中。鉴于这一技术进步在世界范围内的重要性,我们进行了一项文献综述,以确定液体活检在肿瘤学中的使用现状及其目前的临床应用,并特别关注拉丁美洲。
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引用次数: 0
Hepatectomía central combinada con ligadura de la vena porta derecha en un niño con hepatoblastoma bilobar: reporte de un caso 中央肝切除联合右门静脉结扎治疗儿童肝母细胞瘤1例
IF 0.2 Pub Date : 2020-10-28 DOI: 10.35509/01239015.468
L. M. Sanz, Miurkis Endis, F. Llanos, John Chimbo, Xavier Abril, Francisco Faican, A. Vintimilla
ABSTRACT Hepatoblastoma is a malignant tumor. Surgical resection is the goal of treatment. A 7-month-old female patient with a hepatic mass in segments IV A and B, V, and VIII, classified as PRETEXT III. A central hepatectomy preserving segments VI, VII, II, and III, and a double biliodigestive derivation were performed.  The right portal vein involved was ligated to produce a compensatory hyperplasia of the left liver, retaining the right one as an auxiliary. At 14 days, the left liver had increased by 48.1%. As an alternative to transplantation, central hepatectomy was combined with ligation of the right portal vein in a single surgical time.
摘要肝母细胞瘤是一种恶性肿瘤。手术切除是治疗的目标。一名7个月大的女性患者,其肝脏肿块位于IV、A、B、V和VIII节段,分类为PRETEXT III。进行了保留VI、VII、II和III节段的中央肝切除术,并进行了双胆汁消化衍生术。结扎右门静脉,使左肝代偿性增生,保留右门静脉作为辅助。14天时,左肝增加了48.1%。作为移植的替代方案,肝中央切除术结合右门静脉结扎术在一次手术时间内完成。
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引用次数: 1
Modificación de la técnica de Bernard-Burow en la reconstrucción total del labio inferior: presentación de un caso Bernard-Burow技术在下唇完全重建中的改进:一例报告
IF 0.2 Pub Date : 2020-10-27 DOI: 10.35509/01239015.355
Enrique Alonso Chaparro Aranguren
ABSTRACT Lip carcinoma is one of the most common malignancies in the head and neck region. Squamous-cell carcinoma is the most frequent type of histological cell carcinoma, chiefly affecting the lower lip. Different techniques for reconstructing defects of the lower lip after neoplasia resection are used; however, preserving the functionality and aesthetics of this area poses a challenge due to the anatomical position that causes accumulation of saliva, thus delaying the healing process. We present a total lower lip reconstruction extended towards the chin by using the Burow’s triangle, significantly improving functional and aesthetic results.
摘要唇癌是头颈部最常见的恶性肿瘤之一。鳞状细胞癌是最常见的组织细胞癌类型,主要影响下唇。使用不同的技术来重建肿瘤切除术后的下唇缺损;然而,由于解剖位置会导致唾液积聚,从而推迟愈合过程,因此保留该区域的功能和美观性是一项挑战。我们提出了一个完整的下唇重建延伸到下巴通过使用Burow's三角形,显著改善了功能和美观的结果。
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引用次数: 1
Supervivencia global y supervivencia libre de recaída bioquímica en pacientes con cáncer de próstata tratados con radioterapia de intensidad modulada (IMRT) en el Instituto Nacional de Cancerología 在美国国家癌症研究所接受调强放疗(IMRT)治疗的前列腺癌患者的总生存率和生化无复发生存率
IF 0.2 Pub Date : 2020-10-19 DOI: 10.35509/01239015.6
Adriana Jimenez Cotes, Jose Alejandro Esguerra Cantillo, Rosalba Ospino Peña, Laura Morales Ramirez, M. Gomez, Holman Ballesteros, G. González, Jorge Rugeles
Introducción: En el 2018 el cáncer de próstata presentó el segundo lugar en incidencia a nivel mundial (1). Con el avance en la tecnología y la aparición de la radioterapia de intensidad modulada (IMRT), se ha logrado disminuir dosis a tejido sano sin reducir la cobertura del volumen objetivo, permitiendo menor morbilidad asociada por la radioterapia y la posibilidad de escalar la dosis del tratamiento. El objetivo del estudio fue mostrar los resultados en supervivencia global y supervivencia libre de recaída bioquímica en el Instituto Nacional de Cancerología (INC) en los paciente diagnosticados con cáncer de próstata tratados con radioterapia de intensidad modulada (IMRT). Materiales y métodos: la revisión retrospectiva incluyó 98 pacientes, mayores de 40 años con cáncer de próstata, sin evidencia de enfermedad metastásica, tratados con IMRT entre 2008 - 2015, independiente de la supresión androgénica. La dosis administrada de radioterapia varió según su riesgo basado en la clasificación D´Amico. Hallazgos: La mediana de edad fue de 68,5 años, dentro de los cuales 16 pacientes (16%) se catalogaron de bajo riesgo, 33 (34%) de riesgo intermedio y 49 (50 %) de riesgo alto. La dosis media de radioterapia recibida fue de 75,8 Gy. La supervivencia libre de recaída bioquímica a 5 años fue del 78,6 % y la supervivencia global fue 98 %. Conclusión: Se obtuvo una supervivencia global y una supervivencia libre de recaída bioquímica a 5 años del 98% y 73,1% respectivamente.
导言:2018年,前列腺癌的发病率在全球排名第二(1)。随着技术的进步和调强放射治疗(IMRT)的出现,在不减少目标体积覆盖的情况下,成功地减少了对健康组织的剂量,从而降低了与放射治疗相关的发病率和扩大治疗剂量的可能性。这项研究的目的是展示国家癌症研究所(INC)诊断出接受调强放疗(IMRT)治疗的前列腺癌患者的总生存率和无生化复发生存率的结果。材料和方法:回顾性分析包括98名40岁以上前列腺癌患者,没有转移性疾病的证据,在2008-2015年期间接受了独立于雄激素抑制的IMRT治疗。根据动态分类,放射治疗的剂量因其风险而异。发现:中位年龄为68.5岁,其中16名患者(16%)被归类为低风险,33名患者(34%)被归类为中风险,49名患者(50%)被归类为高风险。平均接受放射治疗剂量为75.8 Gy。5年无生化复发生存率为78.6%,总生存率为98%。结论:5年总生存率为98%,无生化复发生存率为73.1%。
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引用次数: 1
Características operativas de técnicas moleculares empleadas para la detección del virus del papiloma humano en el proyecto ESTAMPA ESTAMPA项目中用于检测人类乳头瘤病毒的分子技术的操作特点
IF 0.2 Pub Date : 2020-09-23 DOI: 10.35509/01239015.106
Johana Andrea Lineros-Hurtado, Pilar Romero-Romero, Yuly Milena Salgado-Lerma, Carolina Wiesner-Ceballos
The development and innovation of new technologies has improved the detection of high-risk human papillomavirus infection. Hybrid capture II is an assay that is based on hybridization and chemiluminescence. Cobas HPV Test is a qualitative PCR and Aptima HPV Assay allows to detect the expression of messenger RNA of the high-risk HPV E6 / E7 oncoproteins. These techniques have advantages, in comparison, with conventional cytology that is routinely used for the detection of cervical cancer. In the ESTAMPA study, 13,691 prosecutions were carried out that allowed to identify that for the planning of research projects or for the implementation of HPV screening tests, it is necessary to analyze the advantages and disadvantages of market tests.
新技术的发展和创新提高了对高危人乳头瘤病毒感染的检测。杂交捕获II是一种基于杂交和化学发光的测定方法。Cobas HPV检测是一种定性PCR,Aptima HPV检测可以检测高危HPV E6/E7癌蛋白的信使RNA的表达。与常规用于检测宫颈癌症的传统细胞学相比,这些技术具有优势。在ESTAMPA的研究中,进行了13691次起诉,以确定为了规划研究项目或实施HPV筛查测试,有必要分析市场测试的优缺点。
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引用次数: 0
In memoriam Jose Fernando Robledo 纪念若泽·费尔南多·罗布莱多
IF 0.2 Pub Date : 2020-09-10 DOI: 10.35509/01239015.721
C. Duarte
Es difícil expresar los sentimientos ante la pérdida de un colega y amigo que fue parte del Instituto Nacional de Cancerología (INC) y un gran líder clínico en el campo de la mastología a nivel nacional. El Dr. José Fernando Robledo realizó sus estudios de cirugía general, cirugía de mama y de tejidos blandos en el INC desde 1983 hasta 1989 donde entró a formar parte del Grupo de mama y tejidos blandos.
很难表达对失去一位同事和朋友的感情,他曾是国家癌症研究所(INC)的一员,也是国家乳房学领域的伟大临床领袖。何塞·费尔南多·罗夫莱多博士于1983年至1989年在INC进行了普通外科、乳腺和软组织外科的研究,在那里他加入了乳腺和软组织小组。
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引用次数: 0
Retos para el control del cáncer en Colombia: ante todo más acción. 哥伦比亚癌症控制面临的挑战:首先要采取更多行动。
IF 0.2 Pub Date : 2020-08-28 DOI: 10.35509/01239015.712
L. Gonzalez
La disminucion de la mortalidad por Cancer de Mama, demostrada en algunos paises del mundo, se ha conseguido gracias a la administracion de tratamientos oportunos e integrales y posiblemente a una estrategia de tamizacion formal que incluya a la mamografia como eje principal. La funcion principal de la mamografia de tamizacion es el diagnostico temprano de la enfermedad para lograr reducir la mortalidad por esta causa. La implementacion de estrategias de deteccion temprana en cancer de mama, en Colombia, intenta ejecutarse bajo importantes limitaciones y logisticas de nuestro sistema de salud. Estas estrategias se han venido construyendo de la mano de  centros de tratamiento oncologico integral como el INC, asociaciones cientificas y la experiencia de cientos de medicos especialistas en el manejo de dicha enfermedad.
世界上一些国家的乳腺癌死亡率有所下降,这要归功于及时和全面的治疗,并可能归功于一项以乳房X光检查为主要轴心的正式筛查战略。筛查乳房X光检查的主要功能是早期诊断该疾病,以降低该原因的死亡率。哥伦比亚乳腺癌早期检测战略的实施试图在我国卫生系统的重大限制和后勤条件下实施。这些战略是由INC等综合肿瘤治疗中心、科学协会和数百名专门治疗这种疾病的医生的经验共同制定的。
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引用次数: 0
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Revista Colombiana de Cancerologia
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