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Study of the Alkaloid Polyneuridine as a Drug Candidate for Therapy of Alzheimer's Disease 生物碱聚神经碱作为治疗阿尔茨海默病候选药物的研究
Pub Date : 2021-08-13 DOI: 10.47059/revistageintec.v11i4.2477
Viviane Lima Silva, Valeria Silva
Alzheimer's disease is characterized by the progressive and irreversible loss of natural cognitive functions in most elderly people. There is currently no cure for this neurodegenerative disorder, but there are therapies available on the market based on substances that inhibit acetylcholinesterase and cognitive symptoms as a way to improve cholinergic hypofunction. Polyneuridine is the main indole alkaloid extracted from the bark and leaves of Aspidosperma polyneuron, a brazilian plant species popularly known as peroba-rosa. The objective of this work is to investigate, through a scientific prospection, the polyneuridine alkaloid, as well as its anticholinesterase property, since it is known that the therapy of this disease is based on cholinesterase inhibitors. To carry out the study, two of the main publication databases of journals such as PubMed and Web of Science were analyzed. To search for scientific production, we inserted the following keywords combined with the terms in english to carry out the search in international databases: “Polyneuridine”, “Polyneuridine AND anticholinesterase properties”, “Polyneuridine AND Alzheimer's disease”. The need for studies on this alkaloid is urgent, especially since Brazil holds the plant species that produces the most polyneuridine, but the plant species Aspidosperma polyneuron is on the red line of extinction due to the unbridled exploitation of its wood. It is concluded that if this exploration scenario continues, Brazil will lose a very important pharmacological genetic resource of its plant flora.
阿尔茨海默病的特点是大多数老年人自然认知功能的进行性和不可逆转的丧失。目前还没有治愈这种神经退行性疾病的方法,但市场上有基于抑制乙酰胆碱酯酶和认知症状的物质的治疗方法,作为改善胆碱能功能减退的一种方法。聚神经碱是一种主要的吲哚类生物碱,它是从巴西的一种植物——多刺藤的树皮和叶子中提取出来的。这项工作的目的是通过科学的展望来研究多神经碱生物碱及其抗胆碱酯酶的特性,因为已知这种疾病的治疗是基于胆碱酯酶抑制剂。为了开展这项研究,我们分析了PubMed和Web of Science这两个主要期刊的出版数据库。为了搜索科研成果,我们插入以下关键词,结合英文术语在国际数据库中进行搜索:“Polyneuridine”,“Polyneuridine AND anti - cholinesterase properties”,“Polyneuridine AND Alzheimer's disease”。对这种生物碱的研究是迫切需要的,特别是因为巴西拥有产生多神经碱最多的植物物种,但由于其木材的无限制开采,植物物种Aspidosperma polyneuron处于灭绝的红线上。结论是,如果这种探索情况继续下去,巴西将失去其植物群的一个非常重要的药理遗传资源。
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引用次数: 0
Legal Issues Vis a Vis Online Contracts in Global Scenario 全球情况下在线合同的法律问题
Pub Date : 2021-08-13 DOI: 10.47059/revistageintec.v11i4.2474
N. Saini, A. P. Bhanu
E-contract is a new phenomenon which has grown due to E Commerce. E commerce has created new domains which has no limits in terms of commercial & business transactions. There are no territorial limits in the domain of e-contracts. Physical presence is not a major requirement in e-contracts. However, at the same time the need to govern E contracts has also raised. E contracts are vital part of the E Commerce which cannot be left in vacuum or unregulated. There are major challenges which are posed while transacting at the electronic medium. These issues and challenges need to be addressed properly in order to create a safe and secure electronic platform. The current research paper shall be discussing the basics of e contracts with the major issues and challenges faced while contracting electronically. The author shall be incorporating a few suggestions at the end to secure electronic contracts regime.
电子合同是随着电子商务的发展而发展起来的一种新现象。电子商务创造了新的领域,在商业和商业交易方面没有限制。在电子合同领域没有地域限制。实体存在并不是电子合同的主要要求。然而,与此同时,管理电子合同的必要性也有所提高。电子商务合同是电子商务的重要组成部分,不可能处于真空状态或不受监管。在电子媒介上进行交易时,会遇到一些主要的挑战。为了创建一个安全可靠的电子平台,这些问题和挑战需要得到妥善解决。当前的研究论文将讨论电子合同的基础知识,以及电子合同面临的主要问题和挑战。作者将在最后纳入一些建议,以确保电子合同制度。
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引用次数: 0
Impact of Covid-19 on the Future of HR in India's Service Sector 2019冠状病毒病对印度服务业人力资源未来的影响
Pub Date : 2021-08-13 DOI: 10.47059/revistageintec.v11i4.2476
N. Kumar, Shikha Kapoor
With the transition of working pattern from physical workplaces to remote workplaces amid COVID-19, there has been existence of imbalance in business organizations due to lack of effective communication channels. For continued importance and relevance in modern workplace, it is essential to upgrade the human resources management function such that these issues can be addressed. Thus, this study aims to determine the impact of COVID-19 on the human resource policies and practices in the Indian service sector. For this examination qualitative analysis has been conducted based on 10 HR managers of IT and hospitality industry in Bengaluru, India. Herein, it was observed that HR managers struggled to engage their employees in disciplined manner and there was high resistance in employees to cope up with the newly developed remote working culture of the firms. The interviewees affirmed that several online opportunities like hybrid approach or people centric working style can lead to better management of employees’ wellbeing and derive effectiveness.
随着新冠疫情期间工作模式从实体工作场所向远程工作场所的转变,由于缺乏有效的沟通渠道,商业组织中存在着不平衡。为了在现代工作场所中继续发挥重要性和相关性,必须升级人力资源管理功能,以便解决这些问题。因此,本研究旨在确定COVID-19对印度服务部门人力资源政策和做法的影响。本研究对印度班加罗尔IT和酒店业的10位人力资源经理进行了定性分析。在这里,我们观察到人力资源经理很难以纪律的方式让员工参与进来,员工对应对公司新发展的远程工作文化有很高的抵抗力。受访者肯定了一些在线机会,如混合方法或以人为本的工作方式,可以更好地管理员工的福利,并获得效率。
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引用次数: 4
Data Analytics in Education and Management Decision Styles in the Evidence-based Development of Education 教育中的数据分析和基于证据的教育发展中的管理决策风格
Pub Date : 2021-08-12 DOI: 10.47059/revistageintec.v11i4.2463
O. Fiofanova, G. Savinykh
Introduction: The development of data culture is considered today as a social norm of the "information society". The leaders of education systems are faced with the task of consolidating the activities of "data evangelists", "it-evangelists" (technology evangelists) in education quality management systems. Data analyst competencies should dominate management decision-making. When examining the influence of relevant competencies on the style of management decision-making, we proceed from the existing technological data infrastructure in Russia, and also take into account the role of the public sector in quality control of education. Materials and methods: A review of foreign and domestic sources on the problems of evidence-based management in education has been undertaken. Various aspects of the problem are compared: intercountry and subnational contexts; revealed the role of international comparative research in the development of data analytics competencies. It was studied, using the Alan Rowe methodology, the influence of data analytics competencies on the style of making management decisions. The study sample consisted of 350 people. The author's case simulators were used for the built-in diagnostics of data analytics competencies. Results: The empirical facts of the change in the style of making management decisions under the influence of the competencies of data analytics have been obtained. The relevant competencies were the subject of training for the heads of regional education systems on the basis of the Russian Academy of National Economy and Public Administration. The connection between the competencies of data analytics of the conceptual and analytical style of making management decisions with the content and methodology of training managers has been substantiated. A list of competencies of data analytics for scaling in the practices of training subjects of management of educational systems has been formulated. Discussion and conclusions: The novelty of our proposed solutions lies in the substantiation of the influence of data analytics competencies on the style of management decision-making. We expand the boundaries of the data-driven paradigm of education quality management and consider such systems in the logic of the information-analytical paradigm, where the competence of data analytics is both a condition and a resource for evidence-based education development. Conclusions are formulated about the development of a new type of culture in public administration - data-culture. Data as a valuable asset in a state with a developed data culture changes the ontology of the information state and logically leads to the idea of a new social contract.
数据文化的发展在今天被认为是“信息社会”的一种社会规范。教育系统的领导者面临着整合教育质量管理系统中“数据传道者”、“it传道者”(技术传道者)活动的任务。数据分析师的能力应该主导管理决策。在研究相关能力对管理决策风格的影响时,我们从俄罗斯现有的技术数据基础设施出发,并考虑到公共部门在教育质量控制方面的作用。材料与方法:对国内外有关教育循证管理问题的文献进行了综述。比较了问题的各个方面:国家间和国家以下情况;揭示了国际比较研究在数据分析能力发展中的作用。使用Alan Rowe方法论,研究了数据分析能力对管理决策风格的影响。研究样本由350人组成。作者的案例模拟器被用于数据分析能力的内置诊断。结果:获得了数据分析能力影响下管理决策风格变化的实证事实。有关的能力是在俄罗斯国民经济和公共行政学院的基础上对区域教育系统负责人进行培训的主题。数据分析的能力、作出管理决定的概念和分析风格与培训管理人员的内容和方法之间的联系已得到证实。编制了一份数据分析能力清单,以便在教育系统管理培训科目的实践中扩大规模。讨论和结论:我们提出的解决方案的新颖性在于证实了数据分析能力对管理决策风格的影响。我们扩展了数据驱动的教育质量管理范式的边界,并在信息分析范式的逻辑中考虑这些系统,其中数据分析的能力既是基于证据的教育发展的条件和资源。对公共行政新型文化——数据文化的发展进行了探讨。在一个数据文化发达的国家,数据作为一种有价值的资产,改变了信息状态的本体,并在逻辑上导致了新的社会契约的思想。
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引用次数: 0
Threshold Compare and Load Balancing Algorithm to for Resource Optimization in a Green Cloud 绿色云环境下资源优化的阈值比较与负载均衡算法
Pub Date : 2021-08-12 DOI: 10.47059/revistageintec.v11i4.2473
Nagamani H. Shahapure, P. Rekha, N. Poornima
The reduction in the consumption of energy by the cloud data centers is called as green cloud. Green cloud also helps in restraining the waste disposed to the environment. With the increasing demand in cloud computing, there has been an increase in the energy consumption. Green cloud can be achieved by server consolidation and proper load balancing techniques using virtual machine (VM) migration. It is a feature provided by virtualization. The virtual machines are transferred from one host to another. The overhead associated with migration is performance degradation. This can be overcome by proper load balancing techniques. This helps to curtail the number of VM migrations as well as the energy consumption. In this paper, a technique called as threshold compare and load balance algorithm (TCLBA) is proposed for optimization of the resources at the cloud provider. Two types of threshold are defined for load balancing, namely the lower and upper threshold. This algorithm works on the principle of shifting the load from a server if the load is above the upper threshold or shifting to the server if its load is below the lower threshold. The load is balanced by migrating the VMs. The workload is consolidated to smaller number of hosts such that the remaining hosts are shut down. This method solves the purpose of effective utilization of available resources with lesser energy consumption.
云数据中心能源消耗的减少被称为绿色云。绿云还有助于抑制废物排放到环境中。随着云计算需求的增加,能源消耗也随之增加。绿色云可以通过服务器整合和使用虚拟机(VM)迁移的适当负载平衡技术来实现。这是虚拟化提供的一个特性。虚拟机从一台主机转移到另一台主机。与迁移相关的开销是性能下降。这可以通过适当的负载平衡技术来克服。这有助于减少虚拟机迁移的数量以及能耗。本文提出了一种称为阈值比较和负载平衡算法(TCLBA)的技术,用于优化云提供商的资源。为负载均衡定义了两种类型的阈值,即下限阈值和上限阈值。该算法的工作原理是,如果负载高于上限阈值,则将负载从服务器转移,如果负载低于下限阈值,则将负载转移到服务器。通过迁移虚拟机实现负载均衡。将工作负载整合到更少的主机上,以便关闭剩余的主机。该方法以较少的能耗解决了有效利用可用资源的目的。
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引用次数: 1
Role of Enterprise in Training and Developing Human Resources in Vietnam 企业在培训和开发越南人力资源中的作用
Pub Date : 2021-08-12 DOI: 10.47059/revistageintec.v11i4.2459
D. V. Truong
After 35 years of national renovation and the implementation of the industrialization and modernization policy, our country has initially gained very important achievements in social-economic development. Striving target by 2030 Vietnam fulfills the goal of industrialization and modernization. However, to achieve this, we need to have skilled labor professionally trained to be able to compete in international markets. The role of vocational training is to train people for the labor market and meet the needs of the enterprise which plays an important part in promoting economic growth and job creation. Therefore, the cooperation of the business in vocational training and human resource development is extremely important and becoming more and more urgent.
经过35年的民族革新和工业化、现代化政策的实施,我国在社会经济发展方面取得了初步的重要成就。到2030年,越南实现工业化和现代化的目标。然而,要实现这一目标,我们需要有经过专业培训的熟练劳动力,以便能够在国际市场上竞争。职业培训的作用是为劳动力市场培养人才,满足企业的需要,在促进经济增长和创造就业机会方面起着重要作用。因此,企业在职业培训和人力资源开发方面的合作显得尤为重要,也变得越来越迫切。
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引用次数: 0
Solar Panels and their Diverse Characteristics: An All-Inclusive Study 太阳能电池板及其多种特性:一项全面的研究
Pub Date : 2021-08-12 DOI: 10.47059/revistageintec.v11i4.2472
S. Prasad
In recent years the use of solar energy is found to have grown by a large amount. Solar energy is renewable energy and the demand for it as clean energy shows its growth by nearly 50 percent in the past decade. It is estimated that the sun is able to generate energy within 24 hours that the entire population of the world could consume in 27 years. Solar power is the energy from the sun that is converted into thermal or electrical energy. The energy harnessed from the sun's rays is used for a variety of applications like electricity generation, to provide light for the interior environment, and many other domestic, commercial, and industrial purposes. Usage of fossil fuels for electricity production results in increased pollution and this mandates many governments to encourage moving to electricity generation using solar power. The large amount of solar energy that is available is found to be the most appealing source of electricity. Solar panels form a major part of the solar energy setup. Hence in this article let us review the various types of solar panels. This paper also deals with comparing the merits and demerits of the different types of solar panels that are available in the market. A section that presents the efficiency of the different kinds of the solar panel is also present in this paper. The role of temperature coefficient, fire rating, and hail rating in the performance of the solar panel is also addressed in this paper.
近年来,人们发现太阳能的使用有了很大的增长。太阳能是一种可再生能源,作为清洁能源,其需求在过去十年中增长了近50%。据估计,太阳能够在24小时内产生全世界人口27年消耗的能量。太阳能是太阳转化为热能或电能的能量。从太阳光线中获得的能量用于各种用途,如发电,为室内环境提供照明,以及许多其他家庭,商业和工业用途。使用化石燃料发电导致污染增加,这迫使许多政府鼓励转向使用太阳能发电。人们发现,可利用的大量太阳能是最吸引人的电力来源。太阳能电池板是太阳能装置的主要组成部分。因此,在这篇文章中,让我们回顾一下各种类型的太阳能电池板。本文还比较了市场上不同类型的太阳能电池板的优缺点。本文还介绍了不同种类太阳能电池板的效率。本文还讨论了温度系数、防火等级和冰雹等级对太阳能电池板性能的影响。
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引用次数: 0
Evaluating Employee Innovation and Creativity Towards Employee Turnover Intention in the Malaysian Hospitality Industry 评估员工创新和创造力对员工离职意向在马来西亚酒店业
Pub Date : 2021-08-12 DOI: 10.47059/revistageintec.v11i4.2467
Diyana Kamarudin, Xiaojie Hu, Yasmin Hussain, Y. Ling
Hospitality industry plays a main role and has become a major sector in Malaysia’s economy. However, there are some challenges in the hospitality industry such as employee turnover which could have various consequences to organizations. The purpose of this research is to investigate the factors affecting employee turnover intention, either directly or indirectly. Previous studies have suggested that employee turnover intention could be affected by factors such as leadership, motivation, communication, work environment and infrastructure both directly and indirectly. Employee innovation and creativity as a mediating factor could also affect its relationship with turnover intention of employees. The research design for this study was quantitative research method using questionnaires as the data collection method. Purposive sampling was used to sample 152 hotel employees within the West of Malaysia. Structural Equation Modelling was used to analyze the data using SmartPLS software. Results indicated that leadership, motivation, communication, and work environment and infrastructure had significant relationship with employee innovation and creativity. Apart from that, leadership, motivation and communication also have significant relationship with the employee turnover intention. Turnover is a major issue within companies not only for the company’s sustainability, but also for the health and wellbeing of their employees. As an implication, organizations should understand that their leadership characteristic and environment has a tremendous impact to burnout and employee performance.
酒店业起着主要作用,并已成为马来西亚经济的主要部门。然而,酒店行业也存在一些挑战,如员工流动,这可能对组织产生各种后果。本研究的目的是探讨直接或间接影响员工离职倾向的因素。以往的研究表明,员工离职倾向会受到领导、动机、沟通、工作环境和基础设施等因素的直接和间接影响。员工创新和创造力作为中介因素也会影响其与员工离职意向的关系。本研究的研究设计为定量研究方法,采用问卷调查作为数据收集方法。有目的的抽样被用来对马来西亚西部的152名酒店员工进行抽样。采用结构方程建模方法,利用SmartPLS软件对数据进行分析。结果表明,领导、激励、沟通、工作环境和基础设施对员工创新和创造力有显著影响。除此之外,领导力、动机和沟通对员工离职倾向也有显著的影响。人员流动是公司内部的一个主要问题,不仅关系到公司的可持续发展,也关系到员工的健康和福祉。因此,组织应该明白,他们的领导特征和环境对倦怠和员工绩效有巨大的影响。
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引用次数: 0
Technology for a Systems Approach in the Development of Military Education under the Rapid Development and Growth of Armaments and Equipment 军备装备快速发展壮大背景下军事教育发展的系统路径技术
Pub Date : 2021-08-12 DOI: 10.47059/revistageintec.v11i4.2461
V. Ryzhykov, K. Horiacheva, O. Bondarenko, Oleg Prokhorov, A. Yurkov
Research on military education under the rapid development and growth of armaments and equipment is booming. The field is continually gaining more key insights about this important and complex pedagogical problem. Academic interest on the systemic approach in the development of military education has consistently been a multidisciplinary effort. But perhaps systemic approach in pedagogic researchers are particularly well situated to be the leading voices on the public’s understanding of military education and many are heeding the call. With that responsibility in mind, in this paper, we offer to consider four elements of the educational process for the future of pedagogic research that we believe can help focus this line of inquiry to better ensure we address some of the most pressing problems. Based on critical assessments of the gaps in the literature, the paper cites the need to combine all elements of the educational process into a single system to achieve a focused result in the training of military personnel in educational institutions. Our list is not exhaustive, nor do we suggest that areas we do not cover are not important. Rather, we make these observations with the goal of spurring a conversation about the future of military education research, but especially a systemic approach in the development of military education.
在军备装备快速发展壮大的背景下,军事教育研究蓬勃发展。这个领域正在不断获得关于这个重要而复杂的教学问题的更多关键见解。军事教育发展的系统方法的学术兴趣一直是一个多学科的努力。但是,也许系统方法的教育学研究人员特别适合成为公众对军事教育理解的主要声音,许多人正在倾听这一呼吁。考虑到这一责任,在本文中,我们提出考虑未来教育学研究的教育过程的四个要素,我们相信这些要素可以帮助我们关注这条调查线,以更好地确保我们解决一些最紧迫的问题。根据对文献差距的批判性评估,该文件指出需要将教育过程的所有要素合并为一个单一的系统,以便在教育机构培训军事人员方面取得重点突出的成果。我们的清单并不详尽,我们也不认为我们没有涵盖的领域不重要。相反,我们进行这些观察的目的是促进关于军事教育研究未来的对话,特别是军事教育发展的系统方法。
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引用次数: 0
Input Fields Recognition in Documents Using Deep Learning Techniques 使用深度学习技术识别文档中的输入字段
Pub Date : 2021-08-12 DOI: 10.47059/revistageintec.v11i4.2468
Atharv Nagarikar, Rahul Singh Dangi, Samrit Kumar Maity, Ashish Kuvelkar, Sanjay Wandhekar
Identification of input fields that appear on a document is a crucial requirement while digitizing any document. This paper presents a Deep Learning based approach to detect input fields from a form or document which consists of text, images and input fields like textbox, checkbox. The forms have been crawled and labelled manually to generate a dataset for training Deep Learning models. The YOLO V3 model is trained on the labelled dataset having four classes (static text, static image, input text, checkbox) with 1500 instances. We used bounding box techniques to label the dataset. The paper presents detection of limited types of input fields generally appearing on printed forms. We also discussed how such detection models can scale and sustain higher loads. If given the labelled dataset for other types of input fields, the existing YOLO V3 can be trained for them as well. The model is trained for 3500 iterations and the accuracy achieved is 71 percent.
在对任何文档进行数字化时,识别文档上出现的输入字段是一个至关重要的要求。本文提出了一种基于深度学习的方法来检测由文本、图像和输入字段(如文本框、复选框)组成的表单或文档中的输入字段。这些表格已经被手动抓取和标记,以生成用于训练深度学习模型的数据集。YOLO V3模型在有标签的数据集上进行训练,该数据集有四个类(静态文本、静态图像、输入文本、复选框),有1500个实例。我们使用边界框技术来标记数据集。本文介绍了打印表单中常见的有限类型输入字段的检测。我们还讨论了这样的检测模型如何扩展和维持更高的负载。如果给定其他类型输入字段的标记数据集,现有的YOLO V3也可以针对它们进行训练。该模型经过3500次迭代训练,准确率达到71%。
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引用次数: 2
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Revista Gestão Inovação e Tecnologias
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