首页 > 最新文献

Clinical Epidemiology and Global Health最新文献

英文 中文
Reviewer acknowledgment 2024
IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-01 DOI: 10.1016/j.cegh.2025.101977
{"title":"Reviewer acknowledgment 2024","authors":"","doi":"10.1016/j.cegh.2025.101977","DOIUrl":"10.1016/j.cegh.2025.101977","url":null,"abstract":"","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"31 ","pages":"Article 101977"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mean arterial pressure may be a valuable tool for classifying blood pressure in physically actives: A cross-sectional study among females from North India
IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-01 DOI: 10.1016/j.cegh.2025.101912
Monika Kulshreshtha , Shivani Chandel

Background

Hypertension is a leading global health issue. Prevention, identification, and treatment of hypertension are crucial. Recent studies found that mean arterial pressure (MAP) is better for predicting hypertension than systolic and diastolic blood pressure. Thus, this cross-sectional study compared the prevalence of hypertension among Kathak dancers and physically active non-dancers in North India as per the American Heart Association (AHA) 2017, Indian Guidelines on Hypertension (IGH) 2019, and MAP.

Methods

Data on blood pressure were collected using a standardized procedure from 441 Delhi-National Capital Region females (206 Kathak dancers; 235 age-matched non-dancers). We calculated MAP using Diastolic Blood Pressure + (0.33 ∗ Pulse Pressure). The prevalence of hypertension was estimated using AHA 2017, IGH-IV 2019, and MAP.

Results

The present study revealed that hypertension prevalence varies significantly as per the three guidelines in Kathak dancers and non-dancers. The highest prevalence of hypertension was found with the AHA 2017 criteria, with 13.1 % in Kathak dancers and 31.1 % in non-dancers. This prevalence was reduced to 4.9 % (Kathak dancers) and 6.4 % (non-dancers) as per IGH 2019. When MAP was used, it drastically reduced the prevalence calculated by AHA 2017 (7.2 % Kathak dancers; 17 % non-dancers) and IGH-IV 2019 (.5 % Kathak dancers; 4.3 % non-dancers). Kathak dancers had a lower prevalence of hypertension than non-dancers.

Conclusion

MAP may be a more effective tool for classifying blood pressure than other methods, particularly in physically active populations. Furthermore, the therapeutic movements of Kathak dance may offer a potential preventive strategy for hypertension in the general population.
{"title":"Mean arterial pressure may be a valuable tool for classifying blood pressure in physically actives: A cross-sectional study among females from North India","authors":"Monika Kulshreshtha ,&nbsp;Shivani Chandel","doi":"10.1016/j.cegh.2025.101912","DOIUrl":"10.1016/j.cegh.2025.101912","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension is a leading global health issue. Prevention, identification, and treatment of hypertension are crucial. Recent studies found that mean arterial pressure (MAP) is better for predicting hypertension than systolic and diastolic blood pressure. Thus, this cross-sectional study compared the prevalence of hypertension among Kathak dancers and physically active non-dancers in North India as per the American Heart Association (AHA) 2017, Indian Guidelines on Hypertension (IGH) 2019, and MAP.</div></div><div><h3>Methods</h3><div>Data on blood pressure were collected using a standardized procedure from 441 Delhi-National Capital Region females (206 Kathak dancers; 235 age-matched non-dancers). We calculated MAP using Diastolic Blood Pressure + (0.33 ∗ Pulse Pressure). The prevalence of hypertension was estimated using AHA 2017, IGH-IV 2019, and MAP.</div></div><div><h3>Results</h3><div>The present study revealed that hypertension prevalence varies significantly as per the three guidelines in Kathak dancers and non-dancers. The highest prevalence of hypertension was found with the AHA 2017 criteria, with 13.1 % in Kathak dancers and 31.1 % in non-dancers. This prevalence was reduced to 4.9 % (Kathak dancers) and 6.4 % (non-dancers) as per IGH 2019. When MAP was used, it drastically reduced the prevalence calculated by AHA 2017 (7.2 % Kathak dancers; 17 % non-dancers) and IGH-IV 2019 (.5 % Kathak dancers; 4.3 % non-dancers). Kathak dancers had a lower prevalence of hypertension than non-dancers.</div></div><div><h3>Conclusion</h3><div>MAP may be a more effective tool for classifying blood pressure than other methods, particularly in physically active populations. Furthermore, the therapeutic movements of Kathak dance may offer a potential preventive strategy for hypertension in the general population.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"31 ","pages":"Article 101912"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143165024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trends of needle stick injuries among health care workers in a tertiary care center in South India
IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-01 DOI: 10.1016/j.cegh.2024.101903
Suchitra Shenoy M , Harika Vangara , Joyce Emilda Rego , Irene Saldanha , Gracy Lobo , Shafir Kassim , Shrikala Baliga , Pavan M. R , Pooja Rao

Objectives

Occupation blood exposures can happen in any health care facility. This usually happens due to needle or sharp injuries. The risk of transmission of blood borne pathogens is higher when the injury is due to hollow needle stick injuries. As a protocol the data regarding needle stick injuries in the hospital is captured. This study was taken to analyze the needle stick injuries over the past eleven years.

Methods

A retrospective study was conducted from January 2012 to December 2022 to capture the needle stick injuries that took place in tertiary care hospital in Mangalore, Karnataka over the past 11 years. Data was entered and analyzed on Microsoft excel sheet 2021 (Redmond, Washington).

Results

The trend showed that the incidence of needle stick injury was highest in the years 2013 and 2017. After the year 2013 the incidence drops slightly year after year due to the education and when retraining was reduced the incidence increased in 2017. The 11 years trend showed that doctors had the highest needle stick injury compared to nurses, housekeeping, and technician groups.

Conclusion

The data suggests that the training can reduce the occurrence of needle stick injuries. The proper usage of personal protective equipment should be reinforced at all levels of the health care personnel.
{"title":"Trends of needle stick injuries among health care workers in a tertiary care center in South India","authors":"Suchitra Shenoy M ,&nbsp;Harika Vangara ,&nbsp;Joyce Emilda Rego ,&nbsp;Irene Saldanha ,&nbsp;Gracy Lobo ,&nbsp;Shafir Kassim ,&nbsp;Shrikala Baliga ,&nbsp;Pavan M. R ,&nbsp;Pooja Rao","doi":"10.1016/j.cegh.2024.101903","DOIUrl":"10.1016/j.cegh.2024.101903","url":null,"abstract":"<div><h3>Objectives</h3><div>Occupation blood exposures can happen in any health care facility. This usually happens due to needle or sharp injuries. The risk of transmission of blood borne pathogens is higher when the injury is due to hollow needle stick injuries. As a protocol the data regarding needle stick injuries in the hospital is captured. This study was taken to analyze the needle stick injuries over the past eleven years.</div></div><div><h3>Methods</h3><div>A retrospective study was conducted from January 2012 to December 2022 to capture the needle stick injuries that took place in tertiary care hospital in Mangalore, Karnataka over the past 11 years. Data was entered and analyzed on Microsoft excel sheet 2021 (Redmond, Washington).</div></div><div><h3>Results</h3><div>The trend showed that the incidence of needle stick injury was highest in the years 2013 and 2017. After the year 2013 the incidence drops slightly year after year due to the education and when retraining was reduced the incidence increased in 2017. The 11 years trend showed that doctors had the highest needle stick injury compared to nurses, housekeeping, and technician groups.</div></div><div><h3>Conclusion</h3><div>The data suggests that the training can reduce the occurrence of needle stick injuries. The proper usage of personal protective equipment should be reinforced at all levels of the health care personnel.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"31 ","pages":"Article 101903"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiological changes of common respiratory viruses in Shanghai, during 2021–2023
IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-01 DOI: 10.1016/j.cegh.2024.101905
Sihao Mi , Yuying Yang , Tianming Li

Introduction

The impact of influenza on disease burden is a matter of substantial attention. The influenza viruses (types A and B) and respiratory syncytial virus (RSV) are common causes of influenza-like illness (ILI). The aim of this study was to investigate the epidemic changes of common respiratory viruses in Renji Hospital, one of the largest hospitals in Shanghai, from 2021 to 2023.

Methods

A retrospective analysis was conducted on the nasopharyngeal swab samples of ILI patients from the fever clinic of Renji Hospital from January of 2021 to December of 2023. A thorough analysis was conducted on the epidemiological characteristics across various years and age demographics. Real-time fluorescent quantitative polymerase chain reaction (PCR) was used to detect three common respiratory viruses: influenza A virus (FluA), influenza B virus (FluB), and RSV.

Results

From 2021 to 2023, PCR testing of 125,409 nasopharyngeal samples from patients with ILI revealed an overall positivity rate of 44.65 %, with 38.82 % positive for FluA, 4.02 % for FluB, and 1.81 % for RSV. Age-specific analysis indicated the highest viral positivity rate in the 21–30 age group, with FluA and FluB predominating, while RSV positivity was highest among those aged 0–10 and lower in older age groups. Gender differences in positivity rates were observed across all viruses (P < 0.001), although no significant gender differences were found for FluA and FluB in the 56–65 and 66+ age groups, nor for RSV in those under 18. Seasonal trends showed FluA peaking in summer and winter of 2022 and maintaining high levels throughout 2023, with a slight dip in January and summer. FluB peaked from autumn 2021 to spring 2022 and showed a rising trend in winter 2023, while RSV peaked in early summer of 2023. The interrupted time series analysis showed a significant upward trend in the positivity rate of FluA before the policy change (P < 0.05), but both the immediate impact and the trend change after the policy implementation were not significant (P > 0.05). However, no significant changes were found in the positivity rates of FluB or RSV following the policy change (P > 0.05).

Conclusion

From 2021 to 2023, the influenza outbreak in Shanghai was influenced by the COVID-19 pandemic and health interventions to some extent. The influenza outbreak in Shanghai may become more pronounced after the end of the COVID-19 pandemic. Accordingly, it is essential to rapidly appraise the influenza epidemiological trends and the positivity rate of influenza virus tests.
{"title":"Epidemiological changes of common respiratory viruses in Shanghai, during 2021–2023","authors":"Sihao Mi ,&nbsp;Yuying Yang ,&nbsp;Tianming Li","doi":"10.1016/j.cegh.2024.101905","DOIUrl":"10.1016/j.cegh.2024.101905","url":null,"abstract":"<div><h3>Introduction</h3><div>The impact of influenza on disease burden is a matter of substantial attention. The influenza viruses (types A and B) and respiratory syncytial virus (RSV) are common causes of influenza-like illness (ILI). The aim of this study was to investigate the epidemic changes of common respiratory viruses in Renji Hospital, one of the largest hospitals in Shanghai, from 2021 to 2023.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on the nasopharyngeal swab samples of ILI patients from the fever clinic of Renji Hospital from January of 2021 to December of 2023. A thorough analysis was conducted on the epidemiological characteristics across various years and age demographics. Real-time fluorescent quantitative polymerase chain reaction (PCR) was used to detect three common respiratory viruses: influenza A virus (FluA), influenza B virus (FluB), and RSV.</div></div><div><h3>Results</h3><div>From 2021 to 2023, PCR testing of 125,409 nasopharyngeal samples from patients with ILI revealed an overall positivity rate of 44.65 %, with 38.82 % positive for FluA, 4.02 % for FluB, and 1.81 % for RSV. Age-specific analysis indicated the highest viral positivity rate in the 21–30 age group, with FluA and FluB predominating, while RSV positivity was highest among those aged 0–10 and lower in older age groups. Gender differences in positivity rates were observed across all viruses (<em>P</em> &lt; 0.001), although no significant gender differences were found for FluA and FluB in the 56–65 and 66+ age groups, nor for RSV in those under 18. Seasonal trends showed FluA peaking in summer and winter of 2022 and maintaining high levels throughout 2023, with a slight dip in January and summer. FluB peaked from autumn 2021 to spring 2022 and showed a rising trend in winter 2023, while RSV peaked in early summer of 2023. The interrupted time series analysis showed a significant upward trend in the positivity rate of FluA before the policy change (P &lt; 0.05), but both the immediate impact and the trend change after the policy implementation were not significant (P &gt; 0.05). However, no significant changes were found in the positivity rates of FluB or RSV following the policy change (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>From 2021 to 2023, the influenza outbreak in Shanghai was influenced by the COVID-19 pandemic and health interventions to some extent. The influenza outbreak in Shanghai may become more pronounced after the end of the COVID-19 pandemic. Accordingly, it is essential to rapidly appraise the influenza epidemiological trends and the positivity rate of influenza virus tests.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"31 ","pages":"Article 101905"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between age and patients’ perceptions of safety in hospitals during the COVID-19 pandemic: A cross-sectional study
IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-01 DOI: 10.1016/j.cegh.2024.101869
Ana Lúcia Schaefer Ferreira de Mello , Franciely Daiana Engel , Gabriela Marcellino de Melo Lanzoni , Caroline Cechinel-Peiter , Diovane Ghignatti Costa , José Luis Guedes dos Santos , Alacoque Lorenzini Erdmann , Chantal Backman

Aim

This study aimed to explore patients' perceptions of factors contributing to patient safety during hospitalization for COVID-19, with a focus on differences among three distinct adult age groups.

Methods

A cross-sectional study was conducted. Data were collected from 533 patients hospitalized with COVID-19 in nine Brazilian university hospitals between April and December 2021. Sociodemographics, health conditions, and the Patient Measure of Safety (PMOS) data were gathered via telephone interviews. Descriptive statistics and ANOVA were used to compare the mean scores across PMOS items, domains, and total scores by age groups (18–44; 45–64; and 65+ years).

Results

Patients aged 45–64 years reported the highest perception of safety, while those aged between 18 and 44 years reported the lowest. Statistically significant differences in safety perceptions were observed across age groups. The younger adult group (18–44 years) reported lower overall PMOS scores, particularly in areas such as equipment, access to resources, and organization and care planning, compared to the middle-aged group. Younger adults were more critical of aspects including attentiveness to patient concerns, availability of health professionals, space, and equipment, teamwork skills, and information sharing between the healthcare team and patients.

Conclusion

Perception of factors contributing to patient safety during the COVID-19 pandemic varied across different age groups. Understanding these differences can inform the development of targeted strategies to incorporate patient perspectives into hospital safety initiatives, indicators development, and research to improve patient safety in hospital settings.
{"title":"Association between age and patients’ perceptions of safety in hospitals during the COVID-19 pandemic: A cross-sectional study","authors":"Ana Lúcia Schaefer Ferreira de Mello ,&nbsp;Franciely Daiana Engel ,&nbsp;Gabriela Marcellino de Melo Lanzoni ,&nbsp;Caroline Cechinel-Peiter ,&nbsp;Diovane Ghignatti Costa ,&nbsp;José Luis Guedes dos Santos ,&nbsp;Alacoque Lorenzini Erdmann ,&nbsp;Chantal Backman","doi":"10.1016/j.cegh.2024.101869","DOIUrl":"10.1016/j.cegh.2024.101869","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to explore patients' perceptions of factors contributing to patient safety during hospitalization for COVID-19, with a focus on differences among three distinct adult age groups.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted. Data were collected from 533 patients hospitalized with COVID-19 in nine Brazilian university hospitals between April and December 2021. Sociodemographics, health conditions, and the Patient Measure of Safety (PMOS) data were gathered via telephone interviews. Descriptive statistics and ANOVA were used to compare the mean scores across PMOS items, domains, and total scores by age groups (18–44; 45–64; and 65+ years).</div></div><div><h3>Results</h3><div>Patients aged 45–64 years reported the highest perception of safety, while those aged between 18 and 44 years reported the lowest. Statistically significant differences in safety perceptions were observed across age groups. The younger adult group (18–44 years) reported lower overall PMOS scores, particularly in areas such as equipment, access to resources, and organization and care planning, compared to the middle-aged group. Younger adults were more critical of aspects including attentiveness to patient concerns, availability of health professionals, space, and equipment, teamwork skills, and information sharing between the healthcare team and patients.</div></div><div><h3>Conclusion</h3><div>Perception of factors contributing to patient safety during the COVID-19 pandemic varied across different age groups. Understanding these differences can inform the development of targeted strategies to incorporate patient perspectives into hospital safety initiatives, indicators development, and research to improve patient safety in hospital settings.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"31 ","pages":"Article 101869"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of sodium-glucose Co-transporter 2 inhibitors on MCP-1 and uromodulin levels in patients with type 2 diabetes mellitus
IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-01 DOI: 10.1016/j.cegh.2024.101888
Mani Pathak , Haya Majid , Parvej Khan , Md Masoom , Rizwana Parveen , Prem Kapur , Sunil Kohli , Nidhi

Background and aim

A class of anti-diabetic medications, namely Sodium Glucose Co-Transporter-2 (SGLT2) inhibitors, has shown their potential effects beyond glucose tolerance in Type 2 Diabetes Mellitus (T2DM) patients. These inhibitors may affect inflammatory indicators, including monocyte chemoattractant protein-1 (MCP-1), which contributes to insulin resistance and vascular inflammation. Furthermore, uromodulin levels, a kidney-specific protein linked to renal function and tubular health, may be impacted by SGLT2 inhibitors. The study aimed to assess the role of inflammatory biomarkers in patients with renal dysfunction and T2DM who were receiving SGLT2 inhibitors compared to those receiving antidiabetic medications other than SGLT2 inhibitors.

Methodology

It was a cross-sectional, observational, prospective, and single-centric study that was done to assess serum MCP-1 and uromodulin levels in T2DM patients with early renal dysfunction on SGLT2 inhibitors (n = 28), other antidiabetic medications (n = 28), and healthy controls (n = 30). The study also evaluated associations with glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), estimated glomerular filtration rate (eGFR), serum creatinine, serum urea, serum uric acid, body mass index (BMI), and age.

Results

Serum MCP-1 and uromodulin levels were considerably lower in T2DM patients with early renal impairment who were on SGLT2 inhibitors than in those taking other antidiabetic drugs. Serum uromodulin was found to be negatively correlated with both serum urea and FPG in patients using SGLT2 inhibitors. FPG and serum MCP-1 were significantly correlated negatively in these patients. However, no significant correlation was observed between serum MCP-1 and HbA1c, eGFR, serum creatinine, or serum uric acid.

Conclusion

It has been concluded that patients taking SGLT2 inhibitors are at lower risk of inflammation and renal dysfunction. However, further research is needed to strengthen the evidence of the associations between SGLT2 inhibitors and inflammation.
{"title":"Effect of sodium-glucose Co-transporter 2 inhibitors on MCP-1 and uromodulin levels in patients with type 2 diabetes mellitus","authors":"Mani Pathak ,&nbsp;Haya Majid ,&nbsp;Parvej Khan ,&nbsp;Md Masoom ,&nbsp;Rizwana Parveen ,&nbsp;Prem Kapur ,&nbsp;Sunil Kohli ,&nbsp;Nidhi","doi":"10.1016/j.cegh.2024.101888","DOIUrl":"10.1016/j.cegh.2024.101888","url":null,"abstract":"<div><h3>Background and aim</h3><div>A class of anti-diabetic medications, namely Sodium Glucose Co-Transporter-2 (SGLT2) inhibitors, has shown their potential effects beyond glucose tolerance in Type 2 Diabetes Mellitus (T2DM) patients. These inhibitors may affect inflammatory indicators, including monocyte chemoattractant protein-1 (MCP-1), which contributes to insulin resistance and vascular inflammation. Furthermore, uromodulin levels, a kidney-specific protein linked to renal function and tubular health, may be impacted by SGLT2 inhibitors. The study aimed to assess the role of inflammatory biomarkers in patients with renal dysfunction and T2DM who were receiving SGLT2 inhibitors compared to those receiving antidiabetic medications other than SGLT2 inhibitors.</div></div><div><h3>Methodology</h3><div>It was a cross-sectional, observational, prospective, and single-centric study that was done to assess serum MCP-1 and uromodulin levels in T2DM patients with early renal dysfunction on SGLT2 inhibitors (n = 28), other antidiabetic medications (n = 28), and healthy controls (n = 30). The study also evaluated associations with glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), estimated glomerular filtration rate (eGFR), serum creatinine, serum urea, serum uric acid, body mass index (BMI), and age.</div></div><div><h3>Results</h3><div>Serum MCP-1 and uromodulin levels were considerably lower in T2DM patients with early renal impairment who were on SGLT2 inhibitors than in those taking other antidiabetic drugs. Serum uromodulin was found to be negatively correlated with both serum urea and FPG in patients using SGLT2 inhibitors. FPG and serum MCP-1 were significantly correlated negatively in these patients. However, no significant correlation was observed between serum MCP-1 and HbA1c, eGFR, serum creatinine, or serum uric acid.</div></div><div><h3>Conclusion</h3><div>It has been concluded that patients taking SGLT2 inhibitors are at lower risk of inflammation and renal dysfunction. However, further research is needed to strengthen the evidence of the associations between SGLT2 inhibitors and inflammation.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"31 ","pages":"Article 101888"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Economic burden analysis of nosocomial infections in tertiary care hospital in western India: A prospective evidence-based study
IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-01 DOI: 10.1016/j.cegh.2024.101907
Pranali Patil , Jignesh Shah , Amol Muthal , Asavari Raut

Objective

To evaluate the costs associated with nosocomial infections in a tertiary care hospital in western India.

Materials and methods

This prospective observational study was carried out in a 1000 bedded tertiary care teaching hospital with 100 bedded capacities of interdisciplinary ICUs for a period of 6 months. The costs of illness considered in the study included direct as well as indirect costs.

Results

The most commonly occurring infection among the four categories of HAIs was ventilator-associated pneumonia (VAP) (54.16 %). The direct total costs associated with infected group (752,859 ± 92,233) was found to be significantly higher than uninfected group (290,500 ± 92,233) (p < 0.0001). The direct total costs incurred by VAP (803,605 ± 92,233) was found to be significantly higher followed by CAUTI, SSI and CRBSI. Similarly, the indirect cost was also found to be significant for VAP compared to other types of infections. It was observed that Length of ICU stay 0.997 (31,646–32,767) was significant factor which is responsible for the increase cost of treatment among patients with HAIs (p < 0.0001).

Conclusion

The study highlights that hospital-acquired infections (HAIs) place a substantial financial strain on India's healthcare system. The findings emphasize the necessity for robust infection prevention strategies in hospitals to reduce the incidence of HAIs which could lead to significant cost savings and improved patient outcomes. Future studies could aim to calculate the full economic burden of HAIs, covering not only loss of productivity cost but also mortality and long-term morbidity costs.
{"title":"Economic burden analysis of nosocomial infections in tertiary care hospital in western India: A prospective evidence-based study","authors":"Pranali Patil ,&nbsp;Jignesh Shah ,&nbsp;Amol Muthal ,&nbsp;Asavari Raut","doi":"10.1016/j.cegh.2024.101907","DOIUrl":"10.1016/j.cegh.2024.101907","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the costs associated with nosocomial infections in a tertiary care hospital in western India.</div></div><div><h3>Materials and methods</h3><div>This prospective observational study was carried out in a 1000 bedded tertiary care teaching hospital with 100 bedded capacities of interdisciplinary ICUs for a period of 6 months. The costs of illness considered in the study included direct as well as indirect costs.</div></div><div><h3>Results</h3><div>The most commonly occurring infection among the four categories of HAIs was ventilator-associated pneumonia (VAP) (54.16 %). The direct total costs associated with infected group (752,859 ± 92,233) was found to be significantly higher than uninfected group (290,500 ± 92,233) (<em>p</em> &lt; 0.0001). The direct total costs incurred by VAP (803,605 ± 92,233) was found to be significantly higher followed by CAUTI, SSI and CRBSI. Similarly, the indirect cost was also found to be significant for VAP compared to other types of infections. It was observed that Length of ICU stay 0.997 (31,646–32,767) was significant factor which is responsible for the increase cost of treatment among patients with HAIs (<em>p</em> &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>The study highlights that hospital-acquired infections (HAIs) place a substantial financial strain on India's healthcare system<strong>.</strong> The findings emphasize the necessity for robust infection prevention strategies in hospitals to reduce the incidence of HAIs which could lead to significant cost savings and improved patient outcomes. Future studies could aim to calculate the full economic burden of HAIs, covering not only loss of productivity cost but also mortality and long-term morbidity costs.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"31 ","pages":"Article 101907"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143165025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying accurate methods of assessing blood pressure and health information by lay volunteers in the Philippines: Adapting a Canadian cardiometabolic health program to LMICs
IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-01 DOI: 10.1016/j.cegh.2024.101832
Ricardo Angeles , Floro Dave Arnuco , Fortunato Cristobal , Lisa Dolovich , Janusz Kaczorowski , Dale Guenter , Kasthuri Selvarajah , Fiona Parascandalo , Jessica Gaber , Gina Agarwal

Background

Hypertension is a leading cause of mortality worldwide, especially in low- and middle-income countries (LMICs). In Canada, the Cardiovascular Health Awareness Program (CHAP) was proven effective in reducing cardiovascular hospitalizations. The next research will evaluate an adapted version of CHAP in the southern Philippines (Community Health Assessment Program in the Philippines (CHAP-P)).

Methods

Prior to full program adaptation, this two-phase study was conducted to evaluate the most appropriate methods locally for 1) assessing blood pressure (BP) readings and 2) collecting CHAP-P participant information. Phase 1 compared the correlation (Pearson's r) of BP readings of three automated BP monitoring devices (WatchBP Office Target, Omron HEM-7130, Microlife 3QA1); manual measurement by a health care professional; and the gold standard (trained observers using a mercury sphygmomanometer). Phase 2 compared three data collection methods (tablet, cell phone, and paper) used by Barangay Health Workers (BHWs), the local volunteers who will implement the intervention. Errors, missed data, and BHW experiences were explored during each phase.

Results

Phase 1: the device most highly correlated with the gold standard for systolic BP was the WatchBP Office Target (r = 0.84). For diastolic BP, the WatchBP Office Target produced the same result as the Omron HEM-7130 (r = 0.67). Manual BP measurement showed a very poor correlation (r < 0.60) with the gold standard. Phase 2: BHWs found cell phones and tablets more accurate and easier than paper. They preferred tablets due to the larger screen.

Conclusion

The WatchBP Office target and tablet will be used in the next phase of the project.
{"title":"Identifying accurate methods of assessing blood pressure and health information by lay volunteers in the Philippines: Adapting a Canadian cardiometabolic health program to LMICs","authors":"Ricardo Angeles ,&nbsp;Floro Dave Arnuco ,&nbsp;Fortunato Cristobal ,&nbsp;Lisa Dolovich ,&nbsp;Janusz Kaczorowski ,&nbsp;Dale Guenter ,&nbsp;Kasthuri Selvarajah ,&nbsp;Fiona Parascandalo ,&nbsp;Jessica Gaber ,&nbsp;Gina Agarwal","doi":"10.1016/j.cegh.2024.101832","DOIUrl":"10.1016/j.cegh.2024.101832","url":null,"abstract":"<div><h3>Background</h3><div>Hypertension is a leading cause of mortality worldwide, especially in low- and middle-income countries (LMICs). In Canada, the Cardiovascular Health Awareness Program (CHAP) was proven effective in reducing cardiovascular hospitalizations. The next research will evaluate an adapted version of CHAP in the southern Philippines (Community Health Assessment Program in the Philippines (CHAP-P)).</div></div><div><h3>Methods</h3><div>Prior to full program adaptation, this two-phase study was conducted to evaluate the most appropriate methods locally for 1) assessing blood pressure (BP) readings and 2) collecting CHAP-P participant information. Phase 1 compared the correlation (Pearson's <em>r</em>) of BP readings of three automated BP monitoring devices (WatchBP Office Target, Omron HEM-7130, Microlife 3QA1); manual measurement by a health care professional; and the gold standard (trained observers using a mercury sphygmomanometer). Phase 2 compared three data collection methods (tablet, cell phone, and paper) used by Barangay Health Workers (BHWs), the local volunteers who will implement the intervention. Errors, missed data, and BHW experiences were explored during each phase.</div></div><div><h3>Results</h3><div>Phase 1: the device most highly correlated with the gold standard for systolic BP was the WatchBP Office Target (<em>r</em> = 0.84). For diastolic BP, the WatchBP Office Target produced the same result as the Omron HEM-7130 (<em>r</em> = 0.67). Manual BP measurement showed a very poor correlation (<em>r</em> &lt; 0.60) with the gold standard. Phase 2: BHWs found cell phones and tablets more accurate and easier than paper. They preferred tablets due to the larger screen.</div></div><div><h3>Conclusion</h3><div>The WatchBP Office target and tablet will be used in the next phase of the project.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"31 ","pages":"Article 101832"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does attachment and prenatal depression affect maternal health-promoting lifestyle during pregnancy? A cross-sectional study
IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-01 DOI: 10.1016/j.cegh.2024.101904
Rufidah Maulina , Su-Chen Kuo , Chieh-Yu Liu , Yu Ying Lu , Siti Khuzaiyah , Rafael A. Caparros-Gonzalez

Introduction

A healthy lifestyle during pregnancy is crucial for improving maternal and infant outcomes. Maternal-fetal attachment and maternal prenatal depression have been identified as factors influencing maternal lifestyle during pregnancy. This study aimed to investigate the relationship between maternal-fetal attachment, maternal prenatal depression, and a healthy lifestyle among pregnant women.

Methods

A cross-sectional study was conducted among 224 pregnant women in their third trimester, attending an antenatal appointment at a community health center in Surakarta, Indonesia, from July to September 2019.

Results

Bivariate analysis revealed significant associations between education (p = 0.024), religion (p = 0.026), employment (p = 0.012), income (p = 0.016), parity (p = 0.026), maternal depression (p < 0.01), maternal-fetal attachment (p < 0.001), and a health-promoting lifestyle. However, factors such as age, living arrangement, gestational age, a planned pregnancy, previous miscarriages, pre-pregnancy diseases, pre-pregnancy complications, and a private health insurance showed no significant associations. Hierarchical multiple linear regression indicated that maternal-fetal attachment (p < 0.05) and maternal depression (p < 0.001) were the only predictors of pregnant women's health-promoting lifestyles (R2 = 0.373, ΔR = 0.251).

Conclusion

Maternal-fetal attachment and maternal prenatal depression are key predictors of adopting a health-promoting lifestyle during pregnancy. These findings highlight the importance of maternal psychological well-being as part of a comprehensive antenatal care.
{"title":"Does attachment and prenatal depression affect maternal health-promoting lifestyle during pregnancy? A cross-sectional study","authors":"Rufidah Maulina ,&nbsp;Su-Chen Kuo ,&nbsp;Chieh-Yu Liu ,&nbsp;Yu Ying Lu ,&nbsp;Siti Khuzaiyah ,&nbsp;Rafael A. Caparros-Gonzalez","doi":"10.1016/j.cegh.2024.101904","DOIUrl":"10.1016/j.cegh.2024.101904","url":null,"abstract":"<div><h3>Introduction</h3><div>A healthy lifestyle during pregnancy is crucial for improving maternal and infant outcomes. Maternal-fetal attachment and maternal prenatal depression have been identified as factors influencing maternal lifestyle during pregnancy. This study aimed to investigate the relationship between maternal-fetal attachment, maternal prenatal depression, and a healthy lifestyle among pregnant women.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted among 224 pregnant women in their third trimester, attending an antenatal appointment at a community health center in Surakarta, Indonesia, from July to September 2019.</div></div><div><h3>Results</h3><div>Bivariate analysis revealed significant associations between education (p = 0.024), religion (p = 0.026), employment (p = 0.012), income (p = 0.016), parity (p = 0.026), maternal depression (p &lt; 0.01), maternal-fetal attachment (p &lt; 0.001), and a health-promoting lifestyle. However, factors such as age, living arrangement, gestational age, a planned pregnancy, previous miscarriages, pre-pregnancy diseases, pre-pregnancy complications, and a private health insurance showed no significant associations. Hierarchical multiple linear regression indicated that maternal-fetal attachment (p &lt; 0.05) and maternal depression (p &lt; 0.001) were the only predictors of pregnant women's health-promoting lifestyles (R2 = 0.373, ΔR = 0.251).</div></div><div><h3>Conclusion</h3><div>Maternal-fetal attachment and maternal prenatal depression are key predictors of adopting a health-promoting lifestyle during pregnancy. These findings highlight the importance of maternal psychological well-being as part of a comprehensive antenatal care.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"31 ","pages":"Article 101904"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and risk factors of recurrent ocular injuries: A multicenter retrospective cohort study in four community hospitals, central Thailand
IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-01-01 DOI: 10.1016/j.cegh.2024.101892
Panrawee Sertsuwankul , Chanapat Limprungpattanakit , Panhathai Yaisiri , Ploypun Narindrarangkura , Sethapong Lertsakulbunlue

Introduction

Recurrent ocular injuries increase the risk of long-term ocular complications, which increases public health and economic burden. This study assesses the incidence and risk factors for recurrent ocular injuries in community hospitals in central Thailand, where industrial and agricultural activities heighten risk.

Methods

This retrospective cohort study enrolled patients from four rural community hospitals over six years (October 1, 2018, to September 17, 2024). Patients with ocular injuries were identified using ICD-10 codes, excluding individuals under 20 and revisits. Data collected included patient demographics, injury characteristics, and healthcare access behaviors. Time-to-event analysis begins from the first ocular injury until a subsequent event or study ends. Statistical analyses identified risk factors, with recurrent events analyzed using the Wei-Lin-Weissfeld model.

Results

Of 7189 ocular injury cases, 4373 (60.8 %) were male, with a median age of 43 (IQR 31–57). Most injuries (79.2 %) occurred in industrial settings. Recurrent injuries accounted for 1628 cases (22.7 %), with a rate of 7.6 per 100 person-years. Multivariable analysis showed higher recurrence risk for males (aHR:1.30, 95%CI: 1.07–1.57), age ≥60 (aHR:1.32, 95%CI: 1.04–1.68), and industrial activity (aHR:1.41, 95%CI: 1.10–1.80). Non-urgency cases (aHR:3.32, 95%CI: 1.49–7.42), visits to larger (M2 versus F2) hospitals (aHR:2.98, 95%CI: 1.43–6.20) and outpatient department (aHR:1.43, 95%CI: 1.18–1.74) compared to the emergency department were also linked to higher recurrence.

Conclusion

The findings highlight a substantial incidence of recurrent ocular injuries in rural Thailand, predominantly affecting males and older adults, particularly in industrial sectors. Targeted public health interventions are necessary to enhance injury prevention strategies.
{"title":"Incidence and risk factors of recurrent ocular injuries: A multicenter retrospective cohort study in four community hospitals, central Thailand","authors":"Panrawee Sertsuwankul ,&nbsp;Chanapat Limprungpattanakit ,&nbsp;Panhathai Yaisiri ,&nbsp;Ploypun Narindrarangkura ,&nbsp;Sethapong Lertsakulbunlue","doi":"10.1016/j.cegh.2024.101892","DOIUrl":"10.1016/j.cegh.2024.101892","url":null,"abstract":"<div><h3>Introduction</h3><div>Recurrent ocular injuries increase the risk of long-term ocular complications, which increases public health and economic burden. This study assesses the incidence and risk factors for recurrent ocular injuries in community hospitals in central Thailand, where industrial and agricultural activities heighten risk.</div></div><div><h3>Methods</h3><div>This retrospective cohort study enrolled patients from four rural community hospitals over six years (October 1, 2018, to September 17, 2024). Patients with ocular injuries were identified using ICD-10 codes, excluding individuals under 20 and revisits. Data collected included patient demographics, injury characteristics, and healthcare access behaviors. Time-to-event analysis begins from the first ocular injury until a subsequent event or study ends. Statistical analyses identified risk factors, with recurrent events analyzed using the Wei-Lin-Weissfeld model.</div></div><div><h3>Results</h3><div>Of 7189 ocular injury cases, 4373 (60.8 %) were male, with a median age of 43 (IQR 31–57). Most injuries (79.2 %) occurred in industrial settings. Recurrent injuries accounted for 1628 cases (22.7 %), with a rate of 7.6 per 100 person-years. Multivariable analysis showed higher recurrence risk for males (aHR:1.30, 95%CI: 1.07–1.57), age ≥60 (aHR:1.32, 95%CI: 1.04–1.68), and industrial activity (aHR:1.41, 95%CI: 1.10–1.80). Non-urgency cases (aHR:3.32, 95%CI: 1.49–7.42), visits to larger (M2 versus F2) hospitals (aHR:2.98, 95%CI: 1.43–6.20) and outpatient department (aHR:1.43, 95%CI: 1.18–1.74) compared to the emergency department were also linked to higher recurrence.</div></div><div><h3>Conclusion</h3><div>The findings highlight a substantial incidence of recurrent ocular injuries in rural Thailand, predominantly affecting males and older adults, particularly in industrial sectors. Targeted public health interventions are necessary to enhance injury prevention strategies.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"31 ","pages":"Article 101892"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Clinical Epidemiology and Global Health
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1