Pub Date : 2024-09-24DOI: 10.1101/2023.06.22.546185
Nguyen T Q Nhu, Huaiying Lin, Ying Pigli, Jonathan K Sia, Pola Kuhn, Evan S Snitkin, Vincent Young, Mini Kamboj, Eric G Pamer, Phoebe A Rice, Aimee Shen, Qiwen Dong
Clostridioides difficile RT027 strains cause infections that vary in severity from asymptomatic to lethal, but the molecular basis for this variability is poorly understood. Through comparative analyses of RT027 clinical isolates, we determined that isolates that exhibit greater variability in their flagellar gene expression exhibit greater virulence in vivo. C. difficile flagellar genes are phase-variably expressed due to the site-specific inversion of the flgB 5'UTR region, which reversibly generates ON vs. OFF orientations for the flagellar switch. We found that longer inverted repeat (IR) sequences in this switch region correlate with greater disease severity, with RT027 strains carrying 6A/6T IR sequences exhibiting greater phenotypic heterogeneity in flagellar gene expression (60%-75% ON) and causing more severe disease than those with shorter IRs (> 99% ON or OFF). Taken together, our results reveal that phenotypic heterogeneity in flagellar gene expression may contribute to the variable disease severity observed in C. difficile patients.
{"title":"Flagellar switch inverted repeat impacts flagellar invertibility and varies <i>Clostridioides difficile</i> RT027/MLST1 virulence.","authors":"Nguyen T Q Nhu, Huaiying Lin, Ying Pigli, Jonathan K Sia, Pola Kuhn, Evan S Snitkin, Vincent Young, Mini Kamboj, Eric G Pamer, Phoebe A Rice, Aimee Shen, Qiwen Dong","doi":"10.1101/2023.06.22.546185","DOIUrl":"10.1101/2023.06.22.546185","url":null,"abstract":"<p><p><i>Clostridioides difficile</i> RT027 strains cause infections that vary in severity from asymptomatic to lethal, but the molecular basis for this variability is poorly understood. Through comparative analyses of RT027 clinical isolates, we determined that isolates that exhibit greater variability in their flagellar gene expression exhibit greater virulence <i>in vivo</i>. <i>C. difficile</i> flagellar genes are phase-variably expressed due to the site-specific inversion of the <i>flgB</i> 5'UTR region, which reversibly generates ON vs. OFF orientations for the flagellar switch. We found that longer inverted repeat (IR) sequences in this switch region correlate with greater disease severity, with RT027 strains carrying 6A/6T IR sequences exhibiting greater phenotypic heterogeneity in flagellar gene expression (60%-75% ON) and causing more severe disease than those with shorter IRs (> 99% ON or OFF). Taken together, our results reveal that phenotypic heterogeneity in flagellar gene expression may contribute to the variable disease severity observed in <i>C. difficile</i> patients.</p>","PeriodicalId":47410,"journal":{"name":"Journal of Moral Education","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81307428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-02DOI: 10.1080/03057240.2024.2375805
Elizabeth Cripps
This paper expands the political liberal case for ‘education for justice’ to include climate justice education. It begins with the case for empowering and motivating learners to promote institution...
{"title":"School for sedition? Climate justice, citizenship and education","authors":"Elizabeth Cripps","doi":"10.1080/03057240.2024.2375805","DOIUrl":"https://doi.org/10.1080/03057240.2024.2375805","url":null,"abstract":"This paper expands the political liberal case for ‘education for justice’ to include climate justice education. It begins with the case for empowering and motivating learners to promote institution...","PeriodicalId":47410,"journal":{"name":"Journal of Moral Education","volume":"22 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141936505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-26DOI: 10.1080/03057240.2024.2373167
Evelyn Kropfreiter, Roland Bernhard, Tiarnach McDermott
Recent years have seen increased interest in school-based whole-child development in the Austrian education system. Engaging with this context, the paper provides insights from a quantitative phase...
{"title":"Austrian secondary school teachers’ views on character education: Quantitative insights from a mixed-methods study","authors":"Evelyn Kropfreiter, Roland Bernhard, Tiarnach McDermott","doi":"10.1080/03057240.2024.2373167","DOIUrl":"https://doi.org/10.1080/03057240.2024.2373167","url":null,"abstract":"Recent years have seen increased interest in school-based whole-child development in the Austrian education system. Engaging with this context, the paper provides insights from a quantitative phase...","PeriodicalId":47410,"journal":{"name":"Journal of Moral Education","volume":"12 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-03DOI: 10.1080/03057240.2024.2362996
Jeremy H. Kidwell
In this article, I analyse ways that the modern depersonalisation of knowledge production has contributed to breakdown in climate change education, and by extension, prevented moral and religious e...
{"title":"Personal knowledge: Teaching place-based religious ethics for a climate emergency","authors":"Jeremy H. Kidwell","doi":"10.1080/03057240.2024.2362996","DOIUrl":"https://doi.org/10.1080/03057240.2024.2362996","url":null,"abstract":"In this article, I analyse ways that the modern depersonalisation of knowledge production has contributed to breakdown in climate change education, and by extension, prevented moral and religious e...","PeriodicalId":47410,"journal":{"name":"Journal of Moral Education","volume":"24 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141574340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-29DOI: 10.1080/03057240.2024.2349332
Miloš Broćić, Andrew Miles
Recent evidence suggests that higher education promotes moral attitudes typical of the progressive left. What aspects of the university experience contribute to this moral change? We conduct an exp...
{"title":"The university bundle: Unpacking the sources of undergraduate moral socialization","authors":"Miloš Broćić, Andrew Miles","doi":"10.1080/03057240.2024.2349332","DOIUrl":"https://doi.org/10.1080/03057240.2024.2349332","url":null,"abstract":"Recent evidence suggests that higher education promotes moral attitudes typical of the progressive left. What aspects of the university experience contribute to this moral change? We conduct an exp...","PeriodicalId":47410,"journal":{"name":"Journal of Moral Education","volume":"10 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141743161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-28DOI: 10.1080/03057240.2024.2360210
Bagher Ghobari Bonab, Mohamad Khodayarifard, Ramin Hashemi Geshnigani, Behnaz Khoei, Fatemeh Nosrati, Jacqueline Y. Song, Robert D. Enright
The aim of the current study was to investigate the effect of forgiveness education on positive psychology variables (empathy, altruism and willingness to forgive) in Iranian adolescents. Two hundr...
本研究旨在调查宽恕教育对伊朗青少年积极心理变量（同理心、利他主义和宽恕意愿）的影响。200...
{"title":"Effectiveness of forgiveness education with adolescents in Iran: Increasing the positive psychology of empathy, altruism, and willingness to forgive","authors":"Bagher Ghobari Bonab, Mohamad Khodayarifard, Ramin Hashemi Geshnigani, Behnaz Khoei, Fatemeh Nosrati, Jacqueline Y. Song, Robert D. Enright","doi":"10.1080/03057240.2024.2360210","DOIUrl":"https://doi.org/10.1080/03057240.2024.2360210","url":null,"abstract":"The aim of the current study was to investigate the effect of forgiveness education on positive psychology variables (empathy, altruism and willingness to forgive) in Iranian adolescents. Two hundr...","PeriodicalId":47410,"journal":{"name":"Journal of Moral Education","volume":"68 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141512874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-28DOI: 10.1080/03057240.2024.2365468
Kurt Shaw, Rita de Cácia Oenning da Silva
Though academic research and public policy have directed much attention to how education can promote empathy in children, fewer studies have examined exactly how children define empathy. During the...
{"title":"Brazilian children’s theories of empathy: Exploring character through art","authors":"Kurt Shaw, Rita de Cácia Oenning da Silva","doi":"10.1080/03057240.2024.2365468","DOIUrl":"https://doi.org/10.1080/03057240.2024.2365468","url":null,"abstract":"Though academic research and public policy have directed much attention to how education can promote empathy in children, fewer studies have examined exactly how children define empathy. During the...","PeriodicalId":47410,"journal":{"name":"Journal of Moral Education","volume":"2015 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141501099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-19DOI: 10.1080/03057240.2024.2361509
Michael Bonnett
This paper argues that a proper response to the onset of potentially catastrophic human-induced climate change requires an understanding that is both broader and deeper than that which frequently i...
本文认为，要正确应对人类引发的潜在灾难性气候变化，就必须对气候变化有更广泛、更深刻的认识。
{"title":"Contextualizing climate change education: taking nature seriously","authors":"Michael Bonnett","doi":"10.1080/03057240.2024.2361509","DOIUrl":"https://doi.org/10.1080/03057240.2024.2361509","url":null,"abstract":"This paper argues that a proper response to the onset of potentially catastrophic human-induced climate change requires an understanding that is both broader and deeper than that which frequently i...","PeriodicalId":47410,"journal":{"name":"Journal of Moral Education","volume":"18 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141501100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-18DOI: 10.1080/03057240.2024.2360239
Robbie Nicol, Pete Higgins
Universities occupy a contested space regarding their responses to the climate and nature emergencies. They are criticised for their neoliberalism, marketisation and corporatism yet they provide ed...
{"title":"Teaching to transgress through residential education: Nurturing pedagogical innovation to tackle the climate and nature emergencies in higher education","authors":"Robbie Nicol, Pete Higgins","doi":"10.1080/03057240.2024.2360239","DOIUrl":"https://doi.org/10.1080/03057240.2024.2360239","url":null,"abstract":"Universities occupy a contested space regarding their responses to the climate and nature emergencies. They are criticised for their neoliberalism, marketisation and corporatism yet they provide ed...","PeriodicalId":47410,"journal":{"name":"Journal of Moral Education","volume":"78 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141501101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-02DOI: 10.1080/03057240.2024.2342273
Chiara Palazzolo, Lisa Giombini
This article examines the ethical foundations within classical music performance. It argues that phronesis (practical wisdom) is crucial in navigating the ethical challenges faced by musicians, add...
{"title":"Classical music as ethical practice: A professional perspective","authors":"Chiara Palazzolo, Lisa Giombini","doi":"10.1080/03057240.2024.2342273","DOIUrl":"https://doi.org/10.1080/03057240.2024.2342273","url":null,"abstract":"This article examines the ethical foundations within classical music performance. It argues that phronesis (practical wisdom) is crucial in navigating the ethical challenges faced by musicians, add...","PeriodicalId":47410,"journal":{"name":"Journal of Moral Education","volume":"36 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140930207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"教育学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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