Flood evacuation channel system is intended for flood evacuation. However, it has become a source of waste disposal for the residents, leading to the blocking of flood channels and consequently flooding in some places. This study aimed to assess the impacts of anthropogenic activities that influence the flood evacuation channels system in Anambra State, Nigeria. Primary and secondary data sources were used. The primary data consist of field visits and observations, interviews-cum-questionnaires, and photographs. The secondary data include satellite images from Diva-GIS and other relevant literature. The generated data were analyzed using structural equation model (SEM) in Jamovi. The results revealed that flood channel system inefficiency is attributed to abuse by residents using the system as a waste disposal system. Drainage designs and construction defects in varying the size of the flood channels impede the free flow of runoffs. Drainage channels’ connection and under sizing down slope of the channel system negatively impact the flood evacuation channel system efficiency in some places in the study area.