Pub Date : 2024-04-22DOI: 10.1016/j.dcn.2024.101386
Ethan Roy , Amandine Van Rinsveld , Pierre Nedelec , Adam Richie-Halford , Andreas M. Rauschecker , Leo P. Sugrue , Ariel Rokem , Bruce D. McCandliss , Jason D. Yeatman
Coarse measures of socioeconomic status, such as parental income or parental education, have been linked to differences in white matter development. However, these measures do not provide insight into specific aspects of an individual’s environment and how they relate to brain development. On the other hand, educational intervention studies have shown that changes in an individual’s educational context can drive measurable changes in their white matter. These studies, however, rarely consider socioeconomic factors in their results. In the present study, we examined the unique relationship between educational opportunity and white matter development, when controlling other known socioeconomic factors. To explore this question, we leveraged the rich demographic and neuroimaging data available in the ABCD study, as well the unique data-crosswalk between ABCD and the Stanford Education Data Archive (SEDA). We find that educational opportunity is related to accelerated white matter development, even when accounting for other socioeconomic factors, and that this relationship is most pronounced in white matter tracts associated with academic skills. These results suggest that the school a child attends has a measurable relationship with brain development for years to come.
{"title":"Differences in educational opportunity predict white matter development","authors":"Ethan Roy , Amandine Van Rinsveld , Pierre Nedelec , Adam Richie-Halford , Andreas M. Rauschecker , Leo P. Sugrue , Ariel Rokem , Bruce D. McCandliss , Jason D. Yeatman","doi":"10.1016/j.dcn.2024.101386","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101386","url":null,"abstract":"<div><p>Coarse measures of socioeconomic status, such as parental income or parental education, have been linked to differences in white matter development. However, these measures do not provide insight into specific aspects of an individual’s environment and how they relate to brain development. On the other hand, educational intervention studies have shown that changes in an individual’s educational context can drive measurable changes in their white matter. These studies, however, rarely consider socioeconomic factors in their results. In the present study, we examined the unique relationship between educational opportunity and white matter development, when controlling other known socioeconomic factors. To explore this question, we leveraged the rich demographic and neuroimaging data available in the ABCD study, as well the unique data-crosswalk between ABCD and the Stanford Education Data Archive (SEDA). We find that educational opportunity is related to accelerated white matter development, even when accounting for other socioeconomic factors, and that this relationship is most pronounced in white matter tracts associated with academic skills. These results suggest that the school a child attends has a measurable relationship with brain development for years to come.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000471/pdfft?md5=1cb4218c897fa88170f389eb3a517460&pid=1-s2.0-S1878929324000471-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140650491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12DOI: 10.1016/j.dcn.2024.101380
Tianying Cai , Beiming Yang , Zexi Zhou , Ka I. Ip , Emma K. Adam , Claudia M. Haase , Yang Qu
Research on social determinants of health has highlighted the influence of neighborhood characteristics (e.g., neighborhood safety) on adolescents’ health. However, it is less clear how changes in neighborhood environments play a role in adolescent development, and who are more sensitive to such changes. Utilizing the first three waves of data from the Adolescent Brain Cognitive Development (ABCD) project (N = 7932, M (SD) age = 9.93 (.63) years at T1; 51% boys), the present study found that increases in neighborhood safety were associated with decreased adolescent externalizing symptoms, internalizing symptoms, but not sleep disturbance over time, controlling for baseline neighborhood safety. Further, adolescents’ insula and anterior cingulate cortex (ACC) reactivity to positive emotional stimuli moderated the association between changes in neighborhood safety and adolescent adjustment. Among youth who showed higher, but not lower, insula and ACC reactivity to positive emotion, increases in neighborhood safety were linked with better adjustment. The current study contributes to the differential susceptibility literature by identifying affective neural sensitivity as a marker of youth’s susceptibility to changes in neighborhood environment. The findings highlight the importance of neighborhood safety for youth during the transition to adolescence, particularly for those with heightened affective neural sensitivity.
{"title":"Longitudinal associations between neighborhood safety and adolescent adjustment: The moderating role of affective neural sensitivity","authors":"Tianying Cai , Beiming Yang , Zexi Zhou , Ka I. Ip , Emma K. Adam , Claudia M. Haase , Yang Qu","doi":"10.1016/j.dcn.2024.101380","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101380","url":null,"abstract":"<div><p>Research on social determinants of health has highlighted the influence of neighborhood characteristics (e.g., neighborhood safety) on adolescents’ health. However, it is less clear how <em>changes</em> in neighborhood environments play a role in adolescent development, and who are more sensitive to such changes. Utilizing the first three waves of data from the Adolescent Brain Cognitive Development (ABCD) project (<em>N</em> = 7932, <em>M</em> (<em>SD</em>) <sub>age</sub> = 9.93 (.63) years at T1; 51% boys), the present study found that increases in neighborhood safety were associated with decreased adolescent externalizing symptoms, internalizing symptoms, but not sleep disturbance over time, controlling for baseline neighborhood safety. Further, adolescents’ insula and anterior cingulate cortex (ACC) reactivity to positive emotional stimuli moderated the association between changes in neighborhood safety and adolescent adjustment. Among youth who showed higher, but not lower, insula and ACC reactivity to positive emotion, increases in neighborhood safety were linked with better adjustment. The current study contributes to the differential susceptibility literature by identifying affective neural sensitivity as a marker of youth’s susceptibility to changes in neighborhood environment. The findings highlight the importance of neighborhood safety for youth during the transition to adolescence, particularly for those with heightened affective neural sensitivity.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000410/pdfft?md5=e47bbaffd4f55013cc95903fe2ee14cf&pid=1-s2.0-S1878929324000410-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12DOI: 10.1016/j.dcn.2024.101374
Sofia I. Cárdenas , Yael Waizman , Van Truong , Pia Sellery , Sarah A. Stoycos , Fang-Cheng Yeh , Vidya Rajagopalan , Darby E. Saxbe
The transition to parenthood remains an understudied window of potential neuroplasticity in the adult brain. White matter microstructural (WMM) organization, which reflects structural connectivity in the brain, has shown plasticity across the lifespan. No studies have examined how WMM organization changes from the prenatal to postpartum period in men becoming fathers. This study investigates WMM organization in men transitioning to first-time fatherhood. We performed diffusion-weighted imaging to identify differences in WMM organization, as indexed by fractional anisotropy (FA). We also investigated whether FA changes were associated with fathers’ postpartum mental health. Associations between mental health and WMM organization have not been rarely examined in parents, who may be vulnerable to mental health problems. Fathers exhibited reduced FA at the whole-brain level, especially in the cingulum, a tract associated with emotional regulation. Fathers also displayed reduced FA in the corpus callosum, especially in the forceps minor, which is implicated in cognitive functioning. Postpartum depressive symptoms were linked with increases and decreases in FA, but FA was not correlated with perceived or parenting stress. Findings provide novel insight into fathers’ WMM organization during the transition to parenthood and suggest postpartum depression may be linked with fathers’ neuroplasticity during the transition to parenthood.
为人父母的过渡期仍然是成人大脑潜在神经可塑性的一个研究不足的窗口期。白质微结构(WMM)组织反映了大脑中的结构连接性,在整个生命周期中都表现出可塑性。目前还没有研究探讨过,从产前到产后,成为父亲的男性的白质微结构组织是如何变化的。本研究调查了初为人父的男性的WMM组织。我们进行了扩散加权成像,以确定以分数各向异性(FA)为指标的WMM组织的差异。我们还研究了FA变化是否与父亲的产后心理健康有关。心理健康和WMM组织之间的关系在父母身上还很少被研究,因为他们可能很容易出现心理健康问题。父亲在全脑水平上表现出FA减少,尤其是在与情绪调节相关的扣带回。父亲在胼胝体,尤其是与认知功能有关的小镊子中也显示出减少的FA。产后抑郁症状与 FA 的增减有关,但 FA 与感知压力或养育压力无关。研究结果为父亲在为人父母过程中的WMM组织提供了新的见解,并表明产后抑郁可能与父亲在为人父母过程中的神经可塑性有关。
{"title":"White matter microstructure organization across the transition to fatherhood","authors":"Sofia I. Cárdenas , Yael Waizman , Van Truong , Pia Sellery , Sarah A. Stoycos , Fang-Cheng Yeh , Vidya Rajagopalan , Darby E. Saxbe","doi":"10.1016/j.dcn.2024.101374","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101374","url":null,"abstract":"<div><p>The transition to parenthood remains an understudied window of potential neuroplasticity in the adult brain. White matter microstructural (WMM) organization, which reflects structural connectivity in the brain, has shown plasticity across the lifespan. No studies have examined how WMM organization changes from the prenatal to postpartum period in men becoming fathers. This study investigates WMM organization in men transitioning to first-time fatherhood. We performed diffusion-weighted imaging to identify differences in WMM organization, as indexed by fractional anisotropy (FA). We also investigated whether FA changes were associated with fathers’ postpartum mental health. Associations between mental health and WMM organization have not been rarely examined in parents, who may be vulnerable to mental health problems. Fathers exhibited reduced FA at the whole-brain level, especially in the cingulum, a tract associated with emotional regulation. Fathers also displayed reduced FA in the corpus callosum, especially in the forceps minor, which is implicated in cognitive functioning. Postpartum depressive symptoms were linked with increases and decreases in FA, but FA was not correlated with perceived or parenting stress. Findings provide novel insight into fathers’ WMM organization during the transition to parenthood and suggest postpartum depression may be linked with fathers’ neuroplasticity during the transition to parenthood.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000355/pdfft?md5=f7d7dabe47076319f67358a28188523f&pid=1-s2.0-S1878929324000355-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140551345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-11DOI: 10.1016/j.dcn.2024.101377
Cassandra J. Lowe , Lindsay P. Bodell
Binge eating is characterized as eating a large amount of food and feeling a loss of control while eating. However, the neurobiological mechanisms associated with the onset and maintenance of binge eating are largely unknown. Recent neuroimaging work has suggested that increased responsivity within reward regions of the brain to the anticipation or receipt of rewards is related to binge eating; however, limited longitudinal data has precluded understanding of the role of reward responsivity in the development of binge eating. The current study used data from the Adolescent Brain and Cognitive Development® (ABCD) longitudinal study dataset to assess whether heightened neural responses to different phases of reward processing (reward anticipation and receipt) (1) differentiated individuals with binge eating from matched controls, and (2) predicted the onset of binge eating in an "at risk" sample. Consistent with hypotheses, heightened neural responsivity in the right caudate and bilateral VS during reward anticipation differentiated youth with and without binge eating. Moreover, greater VS response to reward anticipation predicted binge eating two years later. Neural responses to reward receipt also were consistent with hypotheses, such that heightened VS and OFC responses differentiated youth with and without binge eating and predicted the presence of binge eating two years later. Findings from the current study suggest that hypersensitivity to rewards may contribute to the development of binge eating during early adolescence.
{"title":"Examining neural responses to anticipating or receiving monetary rewards and the development of binge eating in youth. A registered report using data from the Adolescent Brain Cognitive Development (ABCD) study","authors":"Cassandra J. Lowe , Lindsay P. Bodell","doi":"10.1016/j.dcn.2024.101377","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101377","url":null,"abstract":"<div><p>Binge eating is characterized as eating a large amount of food and feeling a loss of control while eating. However, the neurobiological mechanisms associated with the onset and maintenance of binge eating are largely unknown. Recent neuroimaging work has suggested that increased responsivity within reward regions of the brain to the anticipation or receipt of rewards is related to binge eating; however, limited longitudinal data has precluded understanding of the role of reward responsivity in the development of binge eating. The current study used data from the Adolescent Brain and Cognitive Development® (ABCD) longitudinal study dataset to assess whether heightened neural responses to different phases of reward processing (reward anticipation and receipt) (1) differentiated individuals with binge eating from matched controls, and (2) predicted the onset of binge eating in an \"at risk\" sample. Consistent with hypotheses, heightened neural responsivity in the right caudate and bilateral VS during reward anticipation differentiated youth with and without binge eating. Moreover, greater VS response to reward anticipation predicted binge eating two years later. Neural responses to reward receipt also were consistent with hypotheses, such that heightened VS and OFC responses differentiated youth with and without binge eating and predicted the presence of binge eating two years later. Findings from the current study suggest that hypersensitivity to rewards may contribute to the development of binge eating during early adolescence.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000380/pdfft?md5=3855e95c9240926b846b3d274fb650f9&pid=1-s2.0-S1878929324000380-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-09DOI: 10.1016/j.dcn.2024.101378
Elizabeth A. Stinson , Ryan M. Sullivan , Gabriella Y. Navarro , Alexander L. Wallace , Christine L. Larson , Krista M. Lisdahl
Adolescence is characterized by dynamic neurodevelopment, which poses opportunities for risk and resilience. Adverse childhood experiences (ACEs) confer additional risk to the developing brain, where ACEs have been associated with alterations in functional magnetic resonance imaging (fMRI) BOLD signaling in brain regions underlying inhibitory control. Socioenvironmental factors like the family environment may amplify or buffer against the neurodevelopmental risks associated with ACEs. Using baseline to Year 2 follow-up data from the Adolescent Brain Cognitive Development (ABCD) Study, the current study examined how ACEs relate to fMRI BOLD signaling during successful inhibition on the Stop Signal Task in regions associated with inhibitory control and examined whether family conflict levels moderated that relationship. Results showed that greater ACEs were associated with reduced BOLD response in the right opercular region of the inferior frontal gyrus and bilaterally in the pre-supplementary motor area, which are key regions underlying inhibitory control. Further, greater BOLD response was correlated with less impulsivity behaviorally, suggesting reduced activation may not be behaviorally adaptive at this age. No significant two or three-way interactions with family conflict levels or time were found. Findings highlight the continued utility of examining the relationship between ACEs and neurodevelopmental outcomes and the importance of intervention/prevention of ACES.
{"title":"Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study","authors":"Elizabeth A. Stinson , Ryan M. Sullivan , Gabriella Y. Navarro , Alexander L. Wallace , Christine L. Larson , Krista M. Lisdahl","doi":"10.1016/j.dcn.2024.101378","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101378","url":null,"abstract":"<div><p>Adolescence is characterized by dynamic neurodevelopment, which poses opportunities for risk and resilience. Adverse childhood experiences (ACEs) confer additional risk to the developing brain, where ACEs have been associated with alterations in functional magnetic resonance imaging (fMRI) BOLD signaling in brain regions underlying inhibitory control. Socioenvironmental factors like the family environment may amplify or buffer against the neurodevelopmental risks associated with ACEs. Using baseline to Year 2 follow-up data from the Adolescent Brain Cognitive Development (ABCD) Study, the current study examined how ACEs relate to fMRI BOLD signaling during successful inhibition on the Stop Signal Task in regions associated with inhibitory control and examined whether family conflict levels moderated that relationship. Results showed that greater ACEs were associated with reduced BOLD response in the right opercular region of the inferior frontal gyrus and bilaterally in the pre-supplementary motor area, which are key regions underlying inhibitory control. Further, greater BOLD response was correlated with less impulsivity behaviorally, suggesting reduced activation may not be behaviorally adaptive at this age. No significant two or three-way interactions with family conflict levels or time were found. Findings highlight the continued utility of examining the relationship between ACEs and neurodevelopmental outcomes and the importance of intervention/prevention of ACES.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000392/pdfft?md5=87a0987e43087be093f26362ad01d95a&pid=1-s2.0-S1878929324000392-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-09DOI: 10.1016/j.dcn.2024.101379
Jana Klaus , Catherine J. Stoodley , Dennis J.L.G. Schutter
Autism spectrum disorder (ASD) is a neurodevelopmental condition frequently associated with structural cerebellar abnormalities. Whether cerebellar grey matter volumes (GMV) are linked to verbal impairments remains controversial. Here, the association between cerebellar GMV and verbal abilities in ASD was examined across the lifespan. Lobular segmentation of the cerebellum was performed on structural MRI scans from the ABIDE I dataset in male individuals with ASD (N=144, age: 8.5–64.0 years) and neurotypical controls (N=188; age: 8.0–56.2 years). Stepwise linear mixed effects modeling including group (ASD vs. neurotypical controls), lobule-wise GMV, and age was performed to identify cerebellar lobules which best predicted verbal abilities as measured by verbal IQ (VIQ). An age-specific association between VIQ and GMV of bilateral Crus II was found in ASD relative to neurotypical controls. In children with ASD, higher VIQ was associated with larger GMV of left Crus II but smaller GMV of right Crus II. By contrast, in adults with ASD, higher VIQ was associated with smaller GMV of left Crus II and larger GMV of right Crus II. These findings indicate that relative to the contralateral hemisphere, an initial reliance on the language-nonspecific left cerebellar hemisphere is offset by more typical right-lateralization in adulthood.
自闭症谱系障碍(ASD)是一种经常与小脑结构异常有关的神经发育疾病。小脑灰质体积(GMV)是否与言语障碍有关仍存在争议。在此,我们研究了ASD患者在整个生命周期中小脑灰质体积与言语能力之间的关系。根据ABIDE I数据集的结构性核磁共振成像扫描结果,对男性ASD患者(144人,年龄:8.5-64.0岁)和神经典型对照组(188人,年龄:8.0-56.2岁)的小脑进行小叶分割。通过逐步线性混合效应建模(包括组别(ASD vs. 神经畸形对照组)、小脑小叶GMV和年龄)来确定最能预测以言语智商(VIQ)衡量的言语能力的小脑小叶。与神经正常对照组相比,ASD 患儿的 VIQ 与双侧 Crus II 的 GMV 之间存在年龄特异性关联。在患有 ASD 的儿童中,VIQ 越高,左侧嵴椎 II 的 GMV 越大,而右侧嵴椎 II 的 GMV 越小。相比之下,在患有 ASD 的成人中,较高的 VIQ 与较小的左侧十字ⅡGMV 和较大的右侧十字ⅡGMV 相关。这些研究结果表明,相对于对侧半球而言,最初对语言无特异性的左侧小脑半球的依赖在成年后被更典型的右侧化所抵消。
{"title":"Neurodevelopmental trajectories of cerebellar grey matter associated with verbal abilities in males with autism spectrum disorder","authors":"Jana Klaus , Catherine J. Stoodley , Dennis J.L.G. Schutter","doi":"10.1016/j.dcn.2024.101379","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101379","url":null,"abstract":"<div><p>Autism spectrum disorder (ASD) is a neurodevelopmental condition frequently associated with structural cerebellar abnormalities. Whether cerebellar grey matter volumes (GMV) are linked to verbal impairments remains controversial. Here, the association between cerebellar GMV and verbal abilities in ASD was examined across the lifespan. Lobular segmentation of the cerebellum was performed on structural MRI scans from the ABIDE I dataset in male individuals with ASD (<em>N</em>=144, age: 8.5–64.0 years) and neurotypical controls (<em>N</em>=188; age: 8.0–56.2 years). Stepwise linear mixed effects modeling including group (ASD vs. neurotypical controls), lobule-wise GMV, and age was performed to identify cerebellar lobules which best predicted verbal abilities as measured by verbal IQ (VIQ). An age-specific association between VIQ and GMV of bilateral Crus II was found in ASD relative to neurotypical controls. In children with ASD, higher VIQ was associated with larger GMV of left Crus II but smaller GMV of right Crus II. By contrast, in adults with ASD, higher VIQ was associated with smaller GMV of left Crus II and larger GMV of right Crus II. These findings indicate that relative to the contralateral hemisphere, an initial reliance on the language-nonspecific left cerebellar hemisphere is offset by more typical right-lateralization in adulthood.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000409/pdfft?md5=e374a1c6010d17961ec06c5d08c7afa7&pid=1-s2.0-S1878929324000409-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1016/j.dcn.2024.101371
Jake J. Son , Abraham D. Killanin , Yasra Arif , Hallie J. Johnson , Hannah J. Okelberry , Lucas Weyrich , Yu-Ping Wang , Vince D. Calhoun , Julia M. Stephen , Brittany K. Taylor , Tony W. Wilson
Throughout childhood and adolescence, the brain undergoes significant structural and functional changes that contribute to the maturation of multiple cognitive domains, including selective attention. Selective attention is crucial for healthy executive functioning and while key brain regions serving selective attention have been identified, their age-related changes in neural oscillatory dynamics and connectivity remain largely unknown. We examined the developmental sensitivity of selective attention circuitry in 91 typically developing youth aged 6 – 13 years old. Participants completed a number-based Simon task while undergoing magnetoencephalography (MEG) and the resulting data were preprocessed and transformed into the time-frequency domain. Significant oscillatory brain responses were imaged using a beamforming approach, and task-related peak voxels in the occipital, parietal, and cerebellar cortices were used as seeds for subsequent whole-brain connectivity analyses in the alpha and gamma range. Our key findings revealed developmentally sensitive connectivity profiles in multiple regions crucial for selective attention, including the temporoparietal junction (alpha) and prefrontal cortex (gamma). Overall, these findings suggest that brain regions serving selective attention are highly sensitive to developmental changes during the pubertal transition period.
{"title":"Developmentally sensitive multispectral cortical connectivity profiles serving visual selective attention","authors":"Jake J. Son , Abraham D. Killanin , Yasra Arif , Hallie J. Johnson , Hannah J. Okelberry , Lucas Weyrich , Yu-Ping Wang , Vince D. Calhoun , Julia M. Stephen , Brittany K. Taylor , Tony W. Wilson","doi":"10.1016/j.dcn.2024.101371","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101371","url":null,"abstract":"<div><p>Throughout childhood and adolescence, the brain undergoes significant structural and functional changes that contribute to the maturation of multiple cognitive domains, including selective attention. Selective attention is crucial for healthy executive functioning and while key brain regions serving selective attention have been identified, their age-related changes in neural oscillatory dynamics and connectivity remain largely unknown. We examined the developmental sensitivity of selective attention circuitry in 91 typically developing youth aged 6 – 13 years old. Participants completed a number-based Simon task while undergoing magnetoencephalography (MEG) and the resulting data were preprocessed and transformed into the time-frequency domain. Significant oscillatory brain responses were imaged using a beamforming approach, and task-related peak voxels in the occipital, parietal, and cerebellar cortices were used as seeds for subsequent whole-brain connectivity analyses in the alpha and gamma range. Our key findings revealed developmentally sensitive connectivity profiles in multiple regions crucial for selective attention, including the temporoparietal junction (alpha) and prefrontal cortex (gamma). Overall, these findings suggest that brain regions serving selective attention are highly sensitive to developmental changes during the pubertal transition period.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S187892932400032X/pdfft?md5=48a96e7b4f7b20299ec4167fc8a61b98&pid=1-s2.0-S187892932400032X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140350785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1016/j.dcn.2024.101372
Daniel R. Leopold , Hyojeong Kim , Kenneth W. Carlson , Mikaela A. Rowe , Boman R. Groff , Moriah P. Major , Erik G. Willcutt , Laurie E. Cutting , Marie T. Banich
This fMRI study of 126 youth explored whether the neural mechanisms underlying the N-back task, commonly used to examine executive control over the contents of working memory, are associated with individual differences in academic achievement in reading and math. Moreover, the study explored whether these relationships occur regardless of the nature of the stimulus being manipulated in working memory (letters, numbers, nonsense shapes) or whether these relationships are specific to achievement domain and stimulus type (i.e., letters for reading and numbers for math). The results indicated that higher academic achievement in each of reading and math was associated with greater activation of dorsolateral prefrontal cortex in the N-back task regardless of stimulus type (i.e., did not differ for letters and numbers), suggesting that at least some aspects of the neural mechanisms underlying these academic domains are executive in nature. In addition, regardless of level of academic achievement, prefrontal regions were engaged to a greater degree for letters than numbers than nonsense shapes. In contrast, nonsense shapes yielded greater hippocampal activation than letters and numbers. Potential reasons for this pattern of findings are discussed.
{"title":"Stimulus shapes strategy: Effects of stimulus characteristics and individual differences in academic achievement on the neural mechanisms engaged during the N-back task","authors":"Daniel R. Leopold , Hyojeong Kim , Kenneth W. Carlson , Mikaela A. Rowe , Boman R. Groff , Moriah P. Major , Erik G. Willcutt , Laurie E. Cutting , Marie T. Banich","doi":"10.1016/j.dcn.2024.101372","DOIUrl":"10.1016/j.dcn.2024.101372","url":null,"abstract":"<div><p>This fMRI study of 126 youth explored whether the neural mechanisms underlying the N-back task, commonly used to examine executive control over the contents of working memory, are associated with individual differences in academic achievement in reading and math. Moreover, the study explored whether these relationships occur regardless of the nature of the stimulus being manipulated in working memory (letters, numbers, nonsense shapes) or whether these relationships are specific to achievement domain and stimulus type (i.e., letters for reading and numbers for math). The results indicated that higher academic achievement in each of reading and math was associated with greater activation of dorsolateral prefrontal cortex in the N-back task regardless of stimulus type (i.e., did not differ for letters and numbers), suggesting that at least some aspects of the neural mechanisms underlying these academic domains are executive in nature. In addition, regardless of level of academic achievement, prefrontal regions were engaged to a greater degree for letters than numbers than nonsense shapes. In contrast, nonsense shapes yielded greater hippocampal activation than letters and numbers. Potential reasons for this pattern of findings are discussed.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000331/pdfft?md5=6d81ac385d92769cbba7b07004e77bfa&pid=1-s2.0-S1878929324000331-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1016/j.dcn.2024.101375
Meriah L. DeJoseph , Monica E. Ellwood-Lowe , Dana Miller-Cotto , David Silverman , Katherine Adams Shannon , Gabriel Reyes , Divyangana Rakesh , Willem E. Frankenhuis
There has been significant progress in understanding the effects of childhood poverty on neurocognitive development. This progress has captured the attention of policymakers and promoted progressive policy reform. However, the prevailing emphasis on the harms associated with childhood poverty may have inadvertently perpetuated a deficit-based narrative, focused on the presumed shortcomings of children and families in poverty. This focus can have unintended consequences for policy (e.g., overlooking strengths) as well as public discourse (e.g., focusing on individual rather than systemic factors). Here, we join scientists across disciplines in arguing for a more well-rounded, “strength-based” approach, which incorporates the positive and/or adaptive developmental responses to experiences of social disadvantage. Specifically, we first show the value of this approach in understanding normative brain development across diverse human environments. We then highlight its application to educational and social policy, explore pitfalls and ethical considerations, and offer practical solutions to conducting strength-based research responsibly. Our paper re-ignites old and recent calls for a strength-based paradigm shift, with a focus on its application to developmental cognitive neuroscience. We also offer a unique perspective from a new generation of early-career researchers engaged in this work, several of whom themselves have grown up in conditions of poverty. Ultimately, we argue that a balanced strength-based scientific approach will be essential to building more effective policies.
{"title":"The promise and pitfalls of a strength-based approach to child poverty and neurocognitive development: Implications for policy","authors":"Meriah L. DeJoseph , Monica E. Ellwood-Lowe , Dana Miller-Cotto , David Silverman , Katherine Adams Shannon , Gabriel Reyes , Divyangana Rakesh , Willem E. Frankenhuis","doi":"10.1016/j.dcn.2024.101375","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101375","url":null,"abstract":"<div><p>There has been significant progress in understanding the effects of childhood poverty on neurocognitive development. This progress has captured the attention of policymakers and promoted progressive policy reform. However, the prevailing emphasis on the harms associated with childhood poverty may have inadvertently perpetuated a deficit-based narrative, focused on the presumed shortcomings of children and families in poverty. This focus can have unintended consequences for policy (e.g., overlooking strengths) as well as public discourse (e.g., focusing on individual rather than systemic factors). Here, we join scientists across disciplines in arguing for a more well-rounded, “strength-based” approach, which incorporates the positive and/or adaptive developmental responses to experiences of social disadvantage. Specifically, we first show the value of this approach in understanding normative brain development across diverse human environments. We then highlight its application to educational and social policy, explore pitfalls and ethical considerations, and offer practical solutions to conducting strength-based research responsibly. Our paper re-ignites old and recent calls for a strength-based paradigm shift, with a focus on its application to developmental cognitive neuroscience. We also offer a unique perspective from a new generation of early-career researchers engaged in this work, several of whom themselves have grown up in conditions of poverty. Ultimately, we argue that a balanced strength-based scientific approach will be essential to building more effective policies.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000367/pdfft?md5=d9c6c63c3410bf113c17894ff72198b8&pid=1-s2.0-S1878929324000367-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140542347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.1016/j.dcn.2024.101370
Arielle S. Keller , Tyler M. Moore , Audrey Luo , Elina Visoki , Mārtiņš M. Gataviņš , Alisha Shetty , Zaixu Cui , Yong Fan , Eric Feczko , Audrey Houghton , Hongming Li , Allyson P. Mackey , Oscar Miranda-Dominguez , Adam Pines , Russell T. Shinohara , Kevin Y. Sun , Damien A. Fair , Theodore D. Satterthwaite , Ran Barzilay
Childhood environments are critical in shaping cognitive neurodevelopment. With the increasing availability of large-scale neuroimaging datasets with deep phenotyping of childhood environments, we can now build upon prior studies that have considered relationships between one or a handful of environmental and neuroimaging features at a time. Here, we characterize the combined effects of hundreds of inter-connected and co-occurring features of a child’s environment (“exposome”) and investigate associations with each child’s unique, multidimensional pattern of functional brain network organization (“functional topography”) and cognition. We apply data-driven computational models to measure the exposome and define personalized functional brain networks in pre-registered analyses. Across matched discovery (n=5139, 48.5% female) and replication (n=5137, 47.1% female) samples from the Adolescent Brain Cognitive Development study, the exposome was associated with current (ages 9–10) and future (ages 11–12) cognition. Changes in the exposome were also associated with changes in cognition after accounting for baseline scores. Cross-validated ridge regressions revealed that the exposome is reflected in functional topography and can predict performance across cognitive domains. Importantly, a single measure capturing a child’s exposome could more accurately and parsimoniously predict cognition than a wealth of personalized neuroimaging data, highlighting the importance of children’s complex, multidimensional environments in cognitive neurodevelopment.
{"title":"A general exposome factor explains individual differences in functional brain network topography and cognition in youth","authors":"Arielle S. Keller , Tyler M. Moore , Audrey Luo , Elina Visoki , Mārtiņš M. Gataviņš , Alisha Shetty , Zaixu Cui , Yong Fan , Eric Feczko , Audrey Houghton , Hongming Li , Allyson P. Mackey , Oscar Miranda-Dominguez , Adam Pines , Russell T. Shinohara , Kevin Y. Sun , Damien A. Fair , Theodore D. Satterthwaite , Ran Barzilay","doi":"10.1016/j.dcn.2024.101370","DOIUrl":"https://doi.org/10.1016/j.dcn.2024.101370","url":null,"abstract":"<div><p>Childhood environments are critical in shaping cognitive neurodevelopment. With the increasing availability of large-scale neuroimaging datasets with deep phenotyping of childhood environments, we can now build upon prior studies that have considered relationships between one or a handful of environmental and neuroimaging features at a time. Here, we characterize the combined effects of hundreds of inter-connected and co-occurring features of a child’s environment (“exposome”) and investigate associations with each child’s unique, multidimensional pattern of functional brain network organization (“functional topography”) and cognition. We apply data-driven computational models to measure the exposome and define personalized functional brain networks in pre-registered analyses. Across matched discovery (n=5139, 48.5% female) and replication (n=5137, 47.1% female) samples from the Adolescent Brain Cognitive Development study, the exposome was associated with current (ages 9–10) and future (ages 11–12) cognition. Changes in the exposome were also associated with changes in cognition after accounting for baseline scores. Cross-validated ridge regressions revealed that the exposome is reflected in functional topography and can predict performance across cognitive domains. Importantly, a single measure capturing a child’s exposome could more accurately and parsimoniously predict cognition than a wealth of personalized neuroimaging data, highlighting the importance of children’s complex, multidimensional environments in cognitive neurodevelopment.</p></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1878929324000318/pdfft?md5=7c77fc572531d535a8609399d1bf0c0d&pid=1-s2.0-S1878929324000318-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140350761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}