Pub Date : 2025-07-23DOI: 10.1016/j.dcn.2025.101599
Itziar Lozano , Anna Duszyk-Bogorodzka , Ingeborg Sophie Ribu , Natalia Falkiewicz , Wiktoria Ogonowska , Agnieszka Dynak , Franziska Köder , Przemysław Tomalski , Ewelina Fryzowska , Grzegorz Krajewski , Cecilie Rummelhoff , Elena C. Varona , Karolina Krupa-Gaweł , Lisa Laumann , Nina Gram Garmann , Ewa Haman
Semantic integration is a mechanism of lexical-semantic processing. When indexed by N400, it emerges coupled with the vocabulary spurt in the second year. To what extent maturation and language exposure contribute to its development remains unclear. Bilingual toddlers split their time between two languages. While experiencing similar concepts as monolinguals, bilinguals are less exposed to each language’s words. This makes them a key group to disentangle the relative contribution of maturation and language exposure in the emergence of semantic integration. We investigate (1) whether bilinguals follow the same developmental trajectory of semantic integration as monolinguals, and (2) whether semantic integration differs between bilinguals’ dominant and non-dominant languages across time. If language exposure drives semantic integration, we expect earlier timing of onset of semantic integration in monolinguals than bilinguals and language-dominance effects within bilinguals. In this event-related potential mixed longitudinal and cross-sectional study (N=131), bilingual and monolingual 18- and 24-month-olds were shown a picture-word priming-paradigm. We found N400 effect at 18 and 24 months in monolinguals. Bilinguals showed no evidence of N400 effect in either the dominant or non-dominant language at any time-point. Although the bilingual sample was smaller than planned, our results contribute to general neurodevelopmental and dual language acquisition models.
{"title":"The development of semantic integration in bilingual toddlers measured by N400","authors":"Itziar Lozano , Anna Duszyk-Bogorodzka , Ingeborg Sophie Ribu , Natalia Falkiewicz , Wiktoria Ogonowska , Agnieszka Dynak , Franziska Köder , Przemysław Tomalski , Ewelina Fryzowska , Grzegorz Krajewski , Cecilie Rummelhoff , Elena C. Varona , Karolina Krupa-Gaweł , Lisa Laumann , Nina Gram Garmann , Ewa Haman","doi":"10.1016/j.dcn.2025.101599","DOIUrl":"10.1016/j.dcn.2025.101599","url":null,"abstract":"<div><div>Semantic integration is a mechanism of lexical-semantic processing. When indexed by N400, it emerges coupled with the vocabulary spurt in the second year. To what extent maturation and language exposure contribute to its development remains unclear. Bilingual toddlers split their time between two languages. While experiencing similar concepts as monolinguals, bilinguals are less exposed to each language’s words. This makes them a key group to disentangle the relative contribution of maturation and language exposure in the emergence of semantic integration. We investigate (1) whether bilinguals follow the same developmental trajectory of semantic integration as monolinguals, and (2) whether semantic integration differs between bilinguals’ dominant and non-dominant languages across time. If language exposure drives semantic integration, we expect earlier timing of onset of semantic integration in monolinguals than bilinguals and language-dominance effects within bilinguals. In this event-related potential mixed longitudinal and cross-sectional study (N=131), bilingual and monolingual 18- and 24-month-olds were shown a picture-word priming<del>-</del>paradigm. We found N400 effect at 18 and 24 months in monolinguals. Bilinguals showed no evidence of N400 effect in either the dominant or non-dominant language at any time-point. Although the bilingual sample was smaller than planned, our results contribute to general neurodevelopmental and dual language acquisition models.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101599"},"PeriodicalIF":4.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144770880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-18DOI: 10.1016/j.dcn.2025.101598
Ga-Ram Jeong , Joram Soch , Robert Trampel , Andreas Nieder , Michael A. Skeide
In the adult brain, hemodynamic responses to visually presented numerosities reveal receptive field-like tuning curves in topographically organized maps across association cortices. It is currently unknown whether such tuned topographic responses to numerosities can also be detected in the developing brain. Here we conducted a 7 Tesla fMRI experiment in which we presented a large set of visual dot displays to children and adults. We found that developing hemodynamic responses indeed already revealed logarithmic Gaussian tuning to quantitative information in children. Remarkably, tuning models explained comparable amounts of variance in children and adults. In most subjects, six bilateral cortical maps consistently exhibited topographic responses to numerosities. The present study goes beyond previous work by uncovering a population code for quantity detection in individual developing human brains. Our work lays a foundation for a model-based neuroimaging approach to individual cognitive differences in the context of developmental dyscalculia and mathematical giftedness.
{"title":"High-field fMRI at 7 Tesla reveals topographic responses tuned to number in the developing human brain","authors":"Ga-Ram Jeong , Joram Soch , Robert Trampel , Andreas Nieder , Michael A. Skeide","doi":"10.1016/j.dcn.2025.101598","DOIUrl":"10.1016/j.dcn.2025.101598","url":null,"abstract":"<div><div>In the adult brain, hemodynamic responses to visually presented numerosities reveal receptive field-like tuning curves in topographically organized maps across association cortices. It is currently unknown whether such tuned topographic responses to numerosities can also be detected in the developing brain. Here we conducted a 7 Tesla fMRI experiment in which we presented a large set of visual dot displays to children and adults. We found that developing hemodynamic responses indeed already revealed logarithmic Gaussian tuning to quantitative information in children. Remarkably, tuning models explained comparable amounts of variance in children and adults. In most subjects, six bilateral cortical maps consistently exhibited topographic responses to numerosities. The present study goes beyond previous work by uncovering a population code for quantity detection in individual developing human brains. Our work lays a foundation for a model-based neuroimaging approach to individual cognitive differences in the context of developmental dyscalculia and mathematical giftedness.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101598"},"PeriodicalIF":4.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-15DOI: 10.1016/j.dcn.2025.101597
Ana Ferariu , Hansoo Chang , Ashni Kumar , Alexandra Sahl , Stephanie Gorka , Lei Wang , Wesley K. Thompson , Fengqing Zhang
Various multilevel, multidomain factors at the individual-, family-, and environmental-level, and changes in neurobiology have been associated with the likelihood of developing alcohol use disorder (AUD) or binge drinking later in life. Prior studies have examined only limited subsets of these factors, typically focusing on cross-sectional associations with alcohol initiation, binge drinking, or AUD rather than exploring longitudinal alcohol use trajectories. Our study addresses these gaps by applying machine learning methods to a comprehensive set of multilevel, multidomain factors and multimodal brain imaging features (including brain structure and functional connectivity) to prospectively predict early alcohol sipping trajectories. Using data from the Adolescent Brain Cognitive Development Study, we identified functional connectivity features and multilevel factors that distinguish youth with an increasing alcohol sipping trajectory from those who initially experimented with alcohol but reduced their consumption over time. Moreover, structural and functional features predicted differences between youth who increasingly sipped over time and those who did not engage in alcohol experimentation. Interactions between age, socioeconomical status and positive attitudes towards drinking could predict a pattern of increasing alcohol sipping over time. These trends could inform how individual, family, environmental and neurobiological factors impact the development of different alcohol sipping trajectories over time.
{"title":"Integrating multilevel, multidomain and multimodal neuroimaging factors to predict early alcohol exposure trajectories using explainable AI","authors":"Ana Ferariu , Hansoo Chang , Ashni Kumar , Alexandra Sahl , Stephanie Gorka , Lei Wang , Wesley K. Thompson , Fengqing Zhang","doi":"10.1016/j.dcn.2025.101597","DOIUrl":"10.1016/j.dcn.2025.101597","url":null,"abstract":"<div><div>Various multilevel, multidomain factors at the individual-, family-, and environmental-level, and changes in neurobiology have been associated with the likelihood of developing alcohol use disorder (AUD) or binge drinking later in life. Prior studies have examined only limited subsets of these factors, typically focusing on cross-sectional associations with alcohol initiation, binge drinking, or AUD rather than exploring longitudinal alcohol use trajectories. Our study addresses these gaps by applying machine learning methods to a comprehensive set of multilevel, multidomain factors and multimodal brain imaging features (including brain structure and functional connectivity) to prospectively predict early alcohol sipping trajectories. Using data from the Adolescent Brain Cognitive Development Study, we identified functional connectivity features and multilevel factors that distinguish youth with an increasing alcohol sipping trajectory from those who initially experimented with alcohol but reduced their consumption over time. Moreover, structural and functional features predicted differences between youth who increasingly sipped over time and those who did not engage in alcohol experimentation. Interactions between age, socioeconomical status and positive attitudes towards drinking could predict a pattern of increasing alcohol sipping over time. These trends could inform how individual, family, environmental and neurobiological factors impact the development of different alcohol sipping trajectories over time.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101597"},"PeriodicalIF":4.6,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-09DOI: 10.1016/j.dcn.2025.101596
Li-Zhen Chen , Xi-Nian Zuo
Functional homotopy, defined as the similarity between the corresponding regions of the two hemispheres, is a critical feature of interhemispheric communication and cognitive integration. Throughout development, the brain transitions from broadly connected networks in early childhood to more specialized configurations in adolescence, accompanied by increased hemispheric differentiation and integration. Using longitudinal data and a novel metric of functional homotopy, Homotopic Functional Affinity (HFA), we investigated the developmental patterns of functional homotopy and its relationship with intelligence. Our findings indicate a significant decrease in HFA with age, particularly in higher-order association networks. In addition, adolescents demonstrate stronger, predominantly negative correlations between HFA and intelligence, in contrast to younger children. In particular, individuals with superior intellectual ability experience accelerated decreases in HFA, indicating greater neural efficiency based on higher hemispheric specialization and differentiation. These findings provide evidence of the neural mechanisms that underlie cognitive development, emphasizing the dynamic interaction between hemispheric organization and intelligence. Our work may inform customized educational and clinical interventions for individual development.
{"title":"Intellectual ability and cortical homotopy development in children and adolescents","authors":"Li-Zhen Chen , Xi-Nian Zuo","doi":"10.1016/j.dcn.2025.101596","DOIUrl":"10.1016/j.dcn.2025.101596","url":null,"abstract":"<div><div>Functional homotopy, defined as the similarity between the corresponding regions of the two hemispheres, is a critical feature of interhemispheric communication and cognitive integration. Throughout development, the brain transitions from broadly connected networks in early childhood to more specialized configurations in adolescence, accompanied by increased hemispheric differentiation and integration. Using longitudinal data and a novel metric of functional homotopy, Homotopic Functional Affinity (HFA), we investigated the developmental patterns of functional homotopy and its relationship with intelligence. Our findings indicate a significant decrease in HFA with age, particularly in higher-order association networks. In addition, adolescents demonstrate stronger, predominantly negative correlations between HFA and intelligence, in contrast to younger children. In particular, individuals with superior intellectual ability experience accelerated decreases in HFA, indicating greater neural efficiency based on higher hemispheric specialization and differentiation. These findings provide evidence of the neural mechanisms that underlie cognitive development, emphasizing the dynamic interaction between hemispheric organization and intelligence. Our work may inform customized educational and clinical interventions for individual development.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101596"},"PeriodicalIF":4.6,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144614810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-07DOI: 10.1016/j.dcn.2025.101595
Sneha Bhargava , Clara G. Zundel , MacKenna Shampine , Samantha Ely , Carmen Carpenter , Jennifer Losiowski , Shravya Chanamolu , Jovan Jande , Reem Tamimi , Kamakashi Sharma , Emilie O’Mara , Alaina M. Jaster , Hilary A. Marusak
Anxiety disorders affect 31.1 % of U.S. adults, with females exhibiting twice the prevalence of males. While sex differences are well-documented, underlying mechanisms remain unclear. Advanced pubertal status is linked to increased anxiety symptoms in females but not males, suggesting puberty contributes to sex differences in fear-based disorders. Deficits in fear extinction and retention are implicated in anxiety, and prior research suggests sex hormones influence extinction retention. This study examined sex assigned at birth (parent-reported) and pubertal status (self-reported) on extinction retention in 101 youth (47.5 % female) using a Pavlovian fear extinction paradigm. Measures included self-reported anxiety symptoms, extinction retention, and neural activation in the amygdala, hippocampus, and anterior cingulate cortex (ACC).
{"title":"Puberty, sex, and fear extinction retention: A neuroimaging study in youth","authors":"Sneha Bhargava , Clara G. Zundel , MacKenna Shampine , Samantha Ely , Carmen Carpenter , Jennifer Losiowski , Shravya Chanamolu , Jovan Jande , Reem Tamimi , Kamakashi Sharma , Emilie O’Mara , Alaina M. Jaster , Hilary A. Marusak","doi":"10.1016/j.dcn.2025.101595","DOIUrl":"10.1016/j.dcn.2025.101595","url":null,"abstract":"<div><div>Anxiety disorders affect 31.1 % of U.S. adults, with females exhibiting twice the prevalence of males. While sex differences are well-documented, underlying mechanisms remain unclear. Advanced pubertal status is linked to increased anxiety symptoms in females but not males, suggesting puberty contributes to sex differences in fear-based disorders. Deficits in fear extinction and retention are implicated in anxiety, and prior research suggests sex hormones influence extinction retention. This study examined sex assigned at birth (parent-reported) and pubertal status (self-reported) on extinction retention in 101 youth (47.5 % female) using a Pavlovian fear extinction paradigm. Measures included self-reported anxiety symptoms, extinction retention, and neural activation in the amygdala, hippocampus, and anterior cingulate cortex (ACC).</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101595"},"PeriodicalIF":4.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-05DOI: 10.1016/j.dcn.2025.101593
Iris Menu , Mark Duffy , Tanya Bhatia , Sofia Trapaga , Jenna John , Selma Music , Daelah Nicholas , Seyeon Yim , Moriah E. Thomason
Preterm birth can significantly impact cognitive development, particularly executive functions (EF). This study investigated hot (with emotional/motivational aspects) and cool (purely neutral/cognitive) EF trajectories in preterm and full-term children, examining brain-behavior relationships. It included 3508 participants aged 9–10 years (mean age 10.0 years) at baseline from the Adolescent Brain and Cognitive Development (ABCD®) study, evenly split between preterm and full-term births (54.36 % males; 1.05 % Asian American, 10.69 % Black, 15.68 % Hispanic, 61.57 % White, 11.09 % other). Participants were followed for 4 years, completing MRI scans and a cool EF task at baseline and at the 2-year follow-up, as well as hot/cool and hot EF tasks at the 1- and 3-year follow-ups. Linear mixed models showed varying effects of preterm birth across the different EF tasks. Specifically, preterm children showed persistent cool EF deficits and a catch-up pattern for hot EF, while performance on the hot/cool task showed no association with preterm birth. Brain-behavior bivariate latent change score analyses identified distinct bidirectional relationships in specific regions, suggesting altered cognitive-brain maturation interactions in preterm children. These findings highlight the complex nature of EF development following preterm birth: while cool EF deficits persist, hot EF shows catch-up growth in preterm children during early adolescence. This emphasizes the need for tailored interventions and long-term follow-up in this population.
{"title":"Large-scale examination of hot and cool executive function in children born preterm","authors":"Iris Menu , Mark Duffy , Tanya Bhatia , Sofia Trapaga , Jenna John , Selma Music , Daelah Nicholas , Seyeon Yim , Moriah E. Thomason","doi":"10.1016/j.dcn.2025.101593","DOIUrl":"10.1016/j.dcn.2025.101593","url":null,"abstract":"<div><div>Preterm birth can significantly impact cognitive development, particularly executive functions (EF). This study investigated hot (with emotional/motivational aspects) and cool (purely neutral/cognitive) EF trajectories in preterm and full-term children, examining brain-behavior relationships. It included 3508 participants aged 9–10 years (mean age 10.0 years) at baseline from the Adolescent Brain and Cognitive Development (ABCD®) study, evenly split between preterm and full-term births (54.36 % males; 1.05 % Asian American, 10.69 % Black, 15.68 % Hispanic, 61.57 % White, 11.09 % other). Participants were followed for 4 years, completing MRI scans and a cool EF task at baseline and at the 2-year follow-up, as well as hot/cool and hot EF tasks at the 1- and 3-year follow-ups. Linear mixed models showed varying effects of preterm birth across the different EF tasks. Specifically, preterm children showed persistent cool EF deficits and a catch-up pattern for hot EF, while performance on the hot/cool task showed no association with preterm birth. Brain-behavior bivariate latent change score analyses identified distinct bidirectional relationships in specific regions, suggesting altered cognitive-brain maturation interactions in preterm children. These findings highlight the complex nature of EF development following preterm birth: while cool EF deficits persist, hot EF shows catch-up growth in preterm children during early adolescence. This emphasizes the need for tailored interventions and long-term follow-up in this population.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101593"},"PeriodicalIF":4.6,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144569912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-04DOI: 10.1016/j.dcn.2025.101594
Jessica S. Flannery , Ashley C. Parr , Kristen A. Lindquist , Eva H. Telzer
When substance use begins during adolescence, it is associated with a greater long-term vulnerability to substance use disorders. Developmental changes in dopaminergic functioning may be involved in substance use initiation and escalation during adolescence. We thus used estimates of tissue iron as a noninvasive, indirect measure of dopamine-related neurophysiology to examine associations between basal ganglia tissue iron development, substance use, and incentive-boosted cognitive control in a longitudinal neuroimaging study. Adolescent participants (N = 168; 51.8 % female) underwent an fMRI scan up to four times across 6th to 11th grade (age range: 11.9–18.6 years old) resulting in 469 fMRI timepoints. Time-averaged and normalized T2*-weighted indices were extracted from basal ganglia subregions at each timepoint. Participants self-reported their past year substance use at each timepoint and completed an incentivized cognitive control task at the final time point (n = 76). In confirmation of prior studies, we show developmental increases in tissue iron at the group level. Adolescents who reported substance use showed attenuated age-related increases in tissue iron in comparison to non-users. Additionally, larger incentive-related modulation of cognitive control was associated with lower iron accumulation across adolescence, although tissue iron was not significantly associated with incentive-related changes in brain activity. Overall, findings suggest that adolescents with diminished age-related increases in basal ganglia tissue iron may have a greater propensity toward substance use. These same individuals may also require greater incentive-driven motivation to reach the same cognitive control performance as their peers. These findings suggest a potential developmental neurophysiological phenotype underlying different incentive-driven behaviors during adolescence.
{"title":"Developmental changes in dopamine-related neurophysiology and associations with adolescent substance use and incentive-boosted cognitive control","authors":"Jessica S. Flannery , Ashley C. Parr , Kristen A. Lindquist , Eva H. Telzer","doi":"10.1016/j.dcn.2025.101594","DOIUrl":"10.1016/j.dcn.2025.101594","url":null,"abstract":"<div><div>When substance use begins during adolescence, it is associated with a greater long-term vulnerability to substance use disorders. Developmental changes in dopaminergic functioning may be involved in substance use initiation and escalation during adolescence. We thus used estimates of tissue iron as a noninvasive, indirect measure of dopamine-related neurophysiology to examine associations between basal ganglia tissue iron development, substance use, and incentive-boosted cognitive control in a longitudinal neuroimaging study. Adolescent participants (N = 168; 51.8 % female) underwent an fMRI scan up to four times across 6th to 11th grade (age range: 11.9–18.6 years old) resulting in 469 fMRI timepoints. Time-averaged and normalized T2*-weighted indices were extracted from basal ganglia subregions at each timepoint. Participants self-reported their past year substance use at each timepoint and completed an incentivized cognitive control task at the final time point (n = 76). In confirmation of prior studies, we show developmental increases in tissue iron at the group level. Adolescents who reported substance use showed attenuated age-related increases in tissue iron in comparison to non-users. Additionally, larger incentive-related modulation of cognitive control was associated with lower iron accumulation across adolescence, although tissue iron was not significantly associated with incentive-related changes in brain activity. Overall, findings suggest that adolescents with diminished age-related increases in basal ganglia tissue iron may have a greater propensity toward substance use. These same individuals may also require greater incentive-driven motivation to reach the same cognitive control performance as their peers. These findings suggest a potential developmental neurophysiological phenotype underlying different incentive-driven behaviors during adolescence.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101594"},"PeriodicalIF":4.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-03DOI: 10.1016/j.dcn.2025.101591
Rosario Pintos Lobo , Julio A. Peraza , Taylor Salo , Alan Meca , Donisha D. Smith , Kathleen E. Feeney , Katherine M. Schmarder , Matthew T. Sutherland , Raul Gonzalez , Erica D. Musser , Angela R. Laird
Social functioning difficulties among youth with attention-deficit/hyperactivity disorder (ADHD) have been examined behaviorally; however, limited research has investigated brain networks associated with social difficulties among youth with ADHD. A growing body of literature supports the utility of the NIMH’s Research Domain Criteria (RDoC) framework, which emphasizes broad neurobiological based dimensions, allowing for the integration of models of both neural circuitry and behavior when examining externalizing behaviors in youth. We hypothesized that an ADHD classification system based on social functioning would better predict real-world psychosocial and academic outcomes compared to traditional Diagnostic and Statistical Manual of Mental Disorders (DSM-5) nosology of ADHD presentations. First, using data from the Adolescent Brain Cognitive Development (ABCD) Study, we identified four distinct profiles of youth with ADHD ranging from low social functioning to high social functioning. These social-data-derived profiles were linked to differential social challenges associated with caregiver income and mental health disorders. Next, our neuroimaging findings initially revealed differential patterns of functional connectivity across profiles involving attention-control, cingulo-opercular, sensorimotor networks. However, these connectivity differences were not consistently replicated, indicating that social functioning alone may not define neurobiologically distinct subgroups. Finally, in comparing our social functioning profiles to existing DSM-5 nosology with respect to real-world psychosocial outcomes, our social profiles demonstrated greater explanatory power for outcomes related to peer relationships, family conflict, and mental health. Overall, these findings emphasize the heterogeneity in social functioning among ADHD youth and suggest that while behavioral profiles are clinically meaningful, future work should integrate additional dimensions, such as executive functioning, to more precisely capture the neurobiological underpinnings of ADHD.
{"title":"Social profiles among youth with attention-deficit/hyperactivity disorder (ADHD): Evidence from the ABCD study","authors":"Rosario Pintos Lobo , Julio A. Peraza , Taylor Salo , Alan Meca , Donisha D. Smith , Kathleen E. Feeney , Katherine M. Schmarder , Matthew T. Sutherland , Raul Gonzalez , Erica D. Musser , Angela R. Laird","doi":"10.1016/j.dcn.2025.101591","DOIUrl":"10.1016/j.dcn.2025.101591","url":null,"abstract":"<div><div>Social functioning difficulties among youth with attention-deficit/hyperactivity disorder (ADHD) have been examined behaviorally; however, limited research has investigated brain networks associated with social difficulties among youth with ADHD. A growing body of literature supports the utility of the NIMH’s Research Domain Criteria (RDoC) framework, which emphasizes broad neurobiological based dimensions, allowing for the integration of models of both neural circuitry and behavior when examining externalizing behaviors in youth. We hypothesized that an ADHD classification system based on social functioning would better predict real-world psychosocial and academic outcomes compared to traditional Diagnostic and Statistical Manual of Mental Disorders (DSM-5) nosology of ADHD presentations. First, using data from the Adolescent Brain Cognitive Development (ABCD) Study, we identified four distinct profiles of youth with ADHD ranging from low social functioning to high social functioning. These social-data-derived profiles were linked to differential social challenges associated with caregiver income and mental health disorders. Next, our neuroimaging findings initially revealed differential patterns of functional connectivity across profiles involving attention-control, cingulo-opercular, sensorimotor networks. However, these connectivity differences were not consistently replicated, indicating that social functioning alone may not define neurobiologically distinct subgroups. Finally, in comparing our social functioning profiles to existing DSM-5 nosology with respect to real-world psychosocial outcomes, our social profiles demonstrated greater explanatory power for outcomes related to peer relationships, family conflict, and mental health. Overall, these findings emphasize the heterogeneity in social functioning among ADHD youth and suggest that while behavioral profiles are clinically meaningful, future work should integrate additional dimensions, such as executive functioning, to more precisely capture the neurobiological underpinnings of ADHD.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101591"},"PeriodicalIF":4.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-03DOI: 10.1016/j.dcn.2025.101592
Shujin Zhou , Yuxuan Zhang , Mingming Zhang , Dan Li
Children are at a critical stage of development for cultivating creativity and are highly sensitive to the influence of peers. This study investigated the impact of peer relationships on children's creativity during both cooperative and competitive interactions, using functional near-infrared spectroscopy (fNIRS)-based hyperscanning techniques. A total of 66 children, including 18 familiar dyads and 15 stranger dyads, were recruited to participate in the cooperative and competitive tangram puzzle tasks. The results showed that familiar dyads demonstrated higher originality and lower appropriateness in cooperative tasks compared to stranger dyads. fNIRS data revealed distinct task-specific neural coupling patterns in the inferior frontal gyrus (IFG) contingent upon peer relationship: familiar dyads exhibited enhanced inter-brain synchronization (IBS) during cooperative tasks, while stranger dyads demonstrated stronger neural alignment during competitive interactions. Additionally, positive feedback during cooperative interactions in familiar dyads was significantly correlated with increased IBS in the IFG. These findings underscore the advantages of familiar peer relationships in fostering cooperative creativity and the benefits of strange relationships in enhancing competitive performance. This study highlights the importance of considering relational and contextual factors in fostering children’s creative potential.
{"title":"The role of peer relationship on children's creativity during cooperative and competitive interactions: An fNIRS-based hyperscanning study","authors":"Shujin Zhou , Yuxuan Zhang , Mingming Zhang , Dan Li","doi":"10.1016/j.dcn.2025.101592","DOIUrl":"10.1016/j.dcn.2025.101592","url":null,"abstract":"<div><div>Children are at a critical stage of development for cultivating creativity and are highly sensitive to the influence of peers. This study investigated the impact of peer relationships on children's creativity during both cooperative and competitive interactions, using functional near-infrared spectroscopy (fNIRS)-based hyperscanning techniques. A total of 66 children, including 18 familiar dyads and 15 stranger dyads, were recruited to participate in the cooperative and competitive tangram puzzle tasks. The results showed that familiar dyads demonstrated higher originality and lower appropriateness in cooperative tasks compared to stranger dyads. fNIRS data revealed distinct task-specific neural coupling patterns in the inferior frontal gyrus (IFG) contingent upon peer relationship: familiar dyads exhibited enhanced inter-brain synchronization (IBS) during cooperative tasks, while stranger dyads demonstrated stronger neural alignment during competitive interactions. Additionally, positive feedback during cooperative interactions in familiar dyads was significantly correlated with increased IBS in the IFG. These findings underscore the advantages of familiar peer relationships in fostering cooperative creativity and the benefits of strange relationships in enhancing competitive performance. This study highlights the importance of considering relational and contextual factors in fostering children’s creative potential.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"75 ","pages":"Article 101592"},"PeriodicalIF":4.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-06-26DOI: 10.1016/j.dcn.2025.101588
Leah D. Church , Nadia Bounoua , Kavya Bhattiprolu , Julia Merker , Jeffrey M. Spielberg
Internalizing disorders are the leading cause of disability worldwide. Despite this public health crisis, borne disproportionately by female adolescents, specific neural mechanisms driving these differences remain unclear. The present study investigated sex differences in the neural circuitry underlying emotion regulation in a community sample of 180 early adolescents (Mage= 12.03 years; 54.4 % female). Participants were instructed to either react naturally or regulate their affective responses to negative or neutral stimuli. Voxelwise analyses revealed a significant 3-way interaction between sex, regulation (e.g., regulate vs. react), and stimulus valence (e.g., negative vs. neutral) in bilateral middle/medial orbitofrontal cortex (OFC), right middle frontal gyrus (MFG), and right amygdala. Specifically, female adolescents recruited bilateral OFC when asked to regulate their responses to aversive images. Recruitment of left (but not right) OFC was greater for male adolescents than female adolescents when regulating their responses to neutral stimuli. Finally, greater deactivation of right MFG was found when female adolescents reacted naturally to aversive stimuli, relative to male adolescents. These regions play critical roles in cognitive processes involved in emotion regulation. Our identification of sex-specific mechanisms supporting affective processes in early adolescents may reflect risk factors that can be intervened upon before the crystallization of internalizing pathology.
{"title":"Sex differences in the neural correlates of affective reactivity and regulation in early adolescence","authors":"Leah D. Church , Nadia Bounoua , Kavya Bhattiprolu , Julia Merker , Jeffrey M. Spielberg","doi":"10.1016/j.dcn.2025.101588","DOIUrl":"10.1016/j.dcn.2025.101588","url":null,"abstract":"<div><div>Internalizing disorders are the leading cause of disability worldwide. Despite this public health crisis, borne disproportionately by female adolescents, specific neural mechanisms driving these differences remain unclear. The present study investigated sex differences in the neural circuitry underlying emotion regulation in a community sample of 180 early adolescents (M<sub>age</sub>= 12.03 years; 54.4 % female). Participants were instructed to either <em>react</em> naturally or <em>regulate</em> their affective responses to <em>negative</em> or <em>neutral</em> stimuli. Voxelwise analyses revealed a significant 3-way interaction between sex, regulation (e.g., regulate vs. react), and stimulus valence (e.g., negative vs. neutral) in bilateral middle/medial orbitofrontal cortex (OFC), right middle frontal gyrus (MFG), and right amygdala. Specifically, female adolescents recruited bilateral OFC when asked to <em>regulate</em> their responses to <em>aversive</em> images. Recruitment of left (but not right) OFC was greater for male adolescents than female adolescents when regulating their responses to <em>neutral</em> stimuli. Finally, greater <em>dea</em>ctivation of right MFG was found when female adolescents <em>reacted naturally</em> to <em>aversive</em> stimuli, relative to male adolescents. These regions play critical roles in cognitive processes involved in emotion regulation. Our identification of sex-specific mechanisms supporting affective processes in early adolescents may reflect risk factors that can be intervened upon before the crystallization of internalizing pathology.</div></div>","PeriodicalId":49083,"journal":{"name":"Developmental Cognitive Neuroscience","volume":"74 ","pages":"Article 101588"},"PeriodicalIF":4.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号