Developmental Cognitive Neuroscience最新文献

英文中文

Self-referential encoding in the developing brain 发育中的大脑中的自我参照编码

IF 4.6 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2025-06-06 DOI: 10.1016/j.dcn.2025.101581

Hilary Sweatman , Ying He , Ross Lawrence , Xiaoqian J. Chai

Episodic memory is closely linked to the self and information related to the self tends to be better remembered. In adults, the brain’s default mode network (DMN) supports self-referential thought and memory, with the medial prefrontal cortex (mPFC) being important for both functions. How the DMN supports self-referential encoding in children, and where in the mPFC the processes of self-referencing and episodic memory interact, is unknown. We investigated the neural development of self-referential encoding in 83 participants ages 7—25. While undergoing MRI, participants viewed objects and answered self-referential or semantic questions. Self-referential compared to semantic encoding resulted in better recollection across all ages. Self-referential encoding was associated with greater activation across the DMN and inferior frontal gyrus (IFG), with age-related increases in the dorsal mPFC and left IFG. Region-of-interest analyses revealed the interaction of self-referential episodic memory in the anterior mPFC and left hippocampus. The dorsal and anterior mPFC showed a counteraction effect of self-related thinking with the previously demonstrated age-related increase in DMN deactivation for subsequent memory encoding. These results suggest that self-referential facilitation matures and interacts with the episodic memory system in the brain to support the development of episodic memory from childhood to adulthood.

情景记忆与自我密切相关，与自我相关的信息往往更容易被记住。在成年人中，大脑的默认模式网络（DMN）支持自我参照思维和记忆，内侧前额叶皮层（mPFC）对这两种功能都很重要。DMN如何支持儿童的自我参照编码，以及在mPFC中自我参照和情景记忆的过程在哪里相互作用，这些都是未知的。研究了83名年龄在7 ~ 25岁的被试的自我参照编码的神经发育情况。在接受核磁共振成像时，参与者观看物体并回答自我指涉或语义问题。与语义编码相比，自我参照在所有年龄段都能产生更好的记忆。自我参照编码与DMN和额下回（IFG）更大的激活有关，与背侧mPFC和左侧IFG的年龄相关的增加有关。兴趣区分析揭示了自我参照情景记忆在前皮层和左海马区的相互作用。背侧和前部的mPFC显示出自我相关思维与先前证明的年龄相关的DMN失活增加的反作用，从而导致随后的记忆编码。这些结果表明，自我指涉促进的成熟并与大脑情景记忆系统相互作用，支持情景记忆从童年到成年的发展。

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引用次数: 0

Parent-adolescent closeness predicts neurophysiological reward responsiveness in adolescent girls at varying risk for depression 父母与青少年的亲密关系可以预测不同抑郁风险的青春期女孩的神经生理奖励反应

IF 4.6 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2025-06-03 DOI: 10.1016/j.dcn.2025.101579

Julianne M. Griffith , Anna Wears , Nastasia O. McDonald , Jennifer S. Silk , Rebecca B. Price , Mary L. Woody

Risk for depression rises during adolescence, particularly among children of depressed mothers. Altered neurophysiological reward processing, measured using event-related potentials (ERPs), is related to depression vulnerability. However, it is unclear whether disruptions in youth reward responsiveness are driven by parental reward dysfunction (e.g., anhedonia) versus parent-child relationship factors (e.g., closeness). This work examined concurrent and prospective associations between youth neurophysiological reward responsiveness and parental anhedonia, parent-adolescent discord, and parent-adolescent closeness. Participants included 93 youth assigned female at birth (ages 13–15) and their mothers (n = 62 with a depression history). Youth reward responsiveness was assessed at baseline and one-year follow-up using the reward positivity (RewP) ERP component. Parental anhedonia, parent-adolescent discord, and parent-adolescent closeness were measured at each timepoint using questionnaires. Regression analyses demonstrated positive concurrent associations between parent-adolescent closeness and youth RewP at both timepoints. RewP was not significantly related to parental anhedonia or parent-adolescent discord, and no prospective cross-lagged effects were observed. Among adolescents at varying depression risk, youth with greater closeness with their mothers consistently demonstrated enhanced reward responsiveness, even after accounting for adolescent depressive symptoms and maternal depression history. Findings suggest that positive, but not negative, aspects of parent-child relationships are related to adolescent responsiveness to reward.

青少年时期患抑郁症的风险增加，尤其是母亲患有抑郁症的孩子。使用事件相关电位（ERPs）测量的神经生理奖励处理改变与抑郁易感性有关。然而，目前尚不清楚青少年奖励反应的中断是由父母奖励功能障碍（如快感缺乏）还是亲子关系因素（如亲密）驱动的。这项工作考察了青少年神经生理奖励反应与父母快感缺乏症、父母-青少年不和以及父母-青少年亲密关系之间的同时和未来的联系。参与者包括93名出生时被指定为女性的青少年（13-15岁）和他们的母亲（n = 62名有抑郁症史的青少年）。青年奖励反应在基线和一年的随访中使用奖励积极性（RewP） ERP组件进行评估。在每个时间点使用问卷测量父母快感缺失、父母-青少年不和和父母-青少年亲密程度。回归分析表明，在两个时间点上，亲子亲密度与青少年RewP之间存在正相关。RewP与父母快感缺乏症或亲子不和无显著相关，且未观察到前瞻性交叉滞后效应。在不同抑郁风险的青少年中，与母亲更亲密的青少年始终表现出更高的奖励反应，即使在考虑了青少年抑郁症状和母亲抑郁史之后也是如此。研究结果表明，亲子关系的积极而非消极方面与青少年对奖励的反应有关。

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引用次数: 0

A six-year longitudinal study examining chronicity and timing of maltreatment effects on risk-related functional connectivity change across adolescence 一项为期六年的纵向研究，研究了虐待对青少年风险相关功能连接变化的慢性和时间影响

IF 4.6 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2025-06-03 DOI: 10.1016/j.dcn.2025.101577

Morgan Lindenmuth , Ya-Yun Chen , Tae-Ho Lee , Natalie Melville , Brooks Casas , Jungmeen Kim-Spoon

Childhood adversity is associated with negative mental health outcomes. Research proposes sensitive periods for the effects of adversity on brain development, yet little is known about the developmental timing effects of abuse and neglect on neural mechanisms underlying risk-related decision making. This study examined 1) trajectories of neural connectivity during risk processing, and 2) how abuse and neglect during early childhood, middle childhood, and adolescence are associated with changes in functional connectivity during risk processing. A sample of 167 adolescents were assessed annually for six years (mean age 14–20 years). Adolescents completed a lottery choice task during a functional magnetic resonance imaging scan (fMRI) and reported maltreatment experiences between ages 1 and 18. Generalized psychophysiological interactions (gPPI) was used to examine task-based functional connectivity in the insula and dorsal anterior cingulate cortex (dACC) during risk processing. Growth curve models revealed increases in insula-dACC connectivity strength across adolescence. Chronic abuse statistically predicted weaker insula-dACC connectivity in late adolescence, and no significant sensitive periods emerged. Results suggest abuse may be linked to delayed maturation in salience network connectivity during risk processing and highlight the importance of distinguishing between effects of abuse and neglect on neural connectivity involved in risk-related decision making.

童年的逆境与负面的心理健康结果有关。研究提出了逆境对大脑发育影响的敏感期，但对虐待和忽视对潜在风险相关决策的神经机制的发育时间影响知之甚少。本研究考察了1)风险处理过程中神经连通性的变化轨迹；2)儿童早期、儿童中期和青少年期的虐待和忽视与风险处理过程中功能连通性的变化之间的关系。对167名青少年样本进行了为期6年的年度评估（平均年龄14-20岁）。在功能磁共振成像扫描（fMRI）期间，青少年完成了彩票选择任务，并报告了1至18岁之间的虐待经历。采用广义心理生理相互作用（gPPI）来检测风险处理过程中脑岛和背前扣带皮层（dACC）基于任务的功能连接。生长曲线模型显示，在整个青春期，脑岛- dacc连接强度有所增加。在统计上，慢性虐待预示着青春期晚期的胰岛素- dacc连接较弱，并且没有明显的敏感期出现。结果表明，虐待可能与风险处理过程中显著性网络连接的延迟成熟有关，并强调了区分虐待和忽视对风险相关决策中神经连接的影响的重要性。

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引用次数: 0

A developmental neuroscience perspective on youth contributions and challenges in a changing society 从发展神经科学的角度看青年在变化社会中的贡献和挑战。

IF 4.6 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2025-06-01 DOI: 10.1016/j.dcn.2025.101558

Kathy T. Do, Suzanne van de Groep, Eveline A. Crone, Christian K. Tamnes

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Highlights of the 2023 Fetal, Infant, and Toddler Neuroimaging Group annual meeting 2023年胎儿、婴儿和幼儿神经影像学小组年会的亮点。

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Developmental Cognitive Neuroscience

Pub Date : 2025-06-01 DOI: 10.1016/j.dcn.2025.101573

Chad M. Sylvester, Marta Korom, M. Catalina Camacho, Sarah Shultz, Tomoki Arichi

引用次数: 0

Erratum to “Capturing the complexity of child behavior and caregiver-child interactions in the HEALthy Brain and Child Development (HBCD) Study using a rigorous and equitable approach” [Dev. Cognit. Neurosci. 69 (2024) 101422] “在健康大脑和儿童发展（HBCD）研究中，使用严格和公平的方法捕捉儿童行为和照顾者与儿童互动的复杂性”[Dev. Cognit]。神经科学，69 (2024)101422 [j]。

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Developmental Cognitive Neuroscience

Pub Date : 2025-06-01 DOI: 10.1016/j.dcn.2025.101571

Renee C. Edwards , Elizabeth M. Planalp , Michelle Bosquet Enlow , Natacha Akshoomoff , Stefanie C. Bodison , Marianne B. Brennan , Lucia Ciciolla , Rina D. Eiden , Courtney A. Fillipi , Hanna C. Gustafsson , Lorraine M. McKelvey , Amanda S. Morris , Myriam Peralta-Carcelén , Julie Poehlmann , Lauren S. Wakschlag , Sylia Wilson , HBCD Child Behavior and Caregiver-Child Interactions Workgroup

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Resting state EEG classifies developmental status in three-year-old children 静息状态脑电图对三岁儿童的发育状态进行分类

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Developmental Cognitive Neuroscience

Pub Date : 2025-05-31 DOI: 10.1016/j.dcn.2025.101575

Dhanya Parameshwaran , Supriya Bhavnani , Debarati Mukherjee , Kamal Kant Sharma , Jennifer Jane Newson , Narayan Puthanmadam Subramaniyam , Gauri Divan , Vikram Patel , Tara C. Thiagarajan

Monitoring cognitive development in early childhood enables detection of problems for timely intervention. However, currently recommended methods require lengthy evaluations of task performance, and are resource intense. Here we examined whether 3 minutes of resting-state EEG (rs-EEG) recorded in 70 33–40-month-old children using a 14-channel portable EEG device in low-resource households could classify performance on five domains of developmental outcomes (cognition, receptive language, expressive language, fine motor and gross motor coordination) as measured by the Bayley’s Scale of Infant and Toddler Development, 3rd Edition (BSID-III). Applying supervised learning models to a combination of spectral features and novel time-domain features derived from EEG data, we predicted BSID-III domain scores with moderate accuracy (AUCs ranging from 0.70 to 0.84 and F1-scores ranging from 0.58 to 0.76). While spectral frequencies significantly correlated with cognitive and language domain scores, time-domain features describing amplitude variability were more significantly correlated and contributed more substantially to model outcomes. Model performance was reliable even with a subset of 4 channels. Overall, this study provides a first demonstration that rs-EEG from low electrode configuration devices can serve as a quick and reliable indicator of cognitive developmental outcomes and aid in identifying those requiring support during early childhood.

监测儿童早期的认知发展可以发现问题并及时进行干预。但是，目前建议的方法需要对任务执行情况进行冗长的评价，而且资源紧张。本文研究了70名低资源家庭中使用14通道便携式脑电图仪记录的3 分钟静息状态脑电图（rs-EEG）是否可以根据Bayley婴幼儿发展量表第三版（BSID-III）对5个发展结果领域（认知、接受性语言、表达性语言、精细运动和大运动协调）的表现进行分类。将监督学习模型应用于从EEG数据中获得的频谱特征和新时域特征的组合，我们以中等精度预测了BSID-III域得分（auc范围为0.70至0.84，f1得分范围为0.58至0.76）。虽然频谱频率与认知和语言域得分显著相关，但描述幅度可变性的时域特征相关性更显著，对模型结果的贡献更大。即使使用4个通道的子集，模型性能也是可靠的。总的来说，这项研究首次证明了低电极配置装置的rs-EEG可以作为认知发展结果的快速可靠指标，并有助于识别儿童早期需要支持的人。

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引用次数: 0

Exposure to unpredictable childhood environments is associated with amygdala activation during early extinction in adulthood 暴露于不可预测的童年环境与成年早期灭绝期间的杏仁核激活有关

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Developmental Cognitive Neuroscience

Pub Date : 2025-05-31 DOI: 10.1016/j.dcn.2025.101578

Jessica M. Duda , Taylor J. Keding , Sahana Kribakaran , Paola Odriozola , Elizabeth R. Kitt , Emily M. Cohodes , Sadie J. Zacharek , Sarah McCauley , Jason T. Haberman , Jutta Joormann , Dylan G. Gee

Early adversity can alter the maturation and function of neural regions that support affective functioning, including threat and safety learning. A growing body of cross-species research has specifically focused on the role of unpredictability in childhood environments in shaping affective functioning; however, the links between childhood unpredictability and neural function related to extinction learning in adulthood remain unclear. In this study, we probed the association between childhood unpredictability, extinction learning, and neural activation in four regions implicated in extinction learning in healthy young adults (N = 45; aged 18–30 years). Results revealed that adults exposed to more unpredictable childhood environments showed greater basolateral amygdala activity to the former (i.e., extinguished) threat cue during early, but not late, extinction, including when controlling for current anxiety and childhood trauma exposure. An exploratory analysis showed that exposure to unpredictable caregiving, but not distal unpredictability (e.g., unpredictability of the physical home or community), specifically drove findings in the amygdala. Childhood unpredictability was not associated with activity in the other regions of interest or with skin conductance response during extinction. These findings add to a growing literature on longstanding impacts of unpredictable caregiving environments, with implications for promoting healthy neurodevelopment and targeted clinical interventions.

早期的逆境可以改变支持情感功能的神经区域的成熟和功能，包括威胁和安全学习。越来越多的跨物种研究特别关注童年环境中不可预测性在塑造情感功能中的作用；然而，儿童时期的不可预测性与成年后与灭绝学习相关的神经功能之间的联系尚不清楚。在这项研究中，我们探讨了童年不可预测性、消失学习和健康年轻人中涉及消失学习的四个区域的神经激活之间的关系(N = 45；18-30岁)。结果显示，暴露在更不可预测的童年环境中的成年人，在早期而不是晚期的灭绝过程中，对前一种（即消失）威胁线索的基底外侧杏仁核活动更大，包括在控制当前焦虑和童年创伤暴露的情况下。一项探索性分析表明，暴露于不可预测的照顾，而不是远端不可预测性（例如，物理家庭或社区的不可预测性），特别推动了杏仁核的发现。儿童时期的不可预测性与其他感兴趣区域的活动或消失期间的皮肤电导反应无关。这些发现增加了越来越多的关于不可预测的护理环境的长期影响的文献，对促进健康的神经发育和有针对性的临床干预具有启示意义。

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引用次数: 0

Statistical learning of orthography-semantics regularities: A developmental neurophysiological study 正字法语义规律的统计学习：一项发育神经生理学研究

IF 4.6 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2025-05-29 DOI: 10.1016/j.dcn.2025.101576

Rujun Duan , Wenyuan Zhao , Shelley Xiuli Tong , Xiuhong Tong

Combining event-related potential (ERP) with an artificial orthography learning paradigm, this study examined how 7–11-year-old Chinese children from first to fifth grade implicitly acquired orthography-semantics regularities of artificial characters. We manipulated the semantic consistency levels of radicals embedded in artificial characters at high (100 %), moderate (80 %), and low (60 %). The behavioral results indicated that 8-year-olds in the second grade were able to acquire regularities of semantic radicals within a sequence of artificial characters. The ERP results revealed a N170-P300-N400 pattern. The N170 component in the occipitotemporal area indicated orthographic identification during the early stages of learning, while the P300 and N400 components reflected attentional allocation and semantic activation during the later stages of statistical learning of orthography-semantics connections. The interactions between neural activation of statistical learning and grade suggest a significant developmental change in 7-11-year-old children. These findings support the multi-component model of statistical learning and the age-related hypothesis.

结合事件相关电位（ERP）和人工正字法学习范式，研究了7 - 11岁中国一至五年级儿童人工汉字的正字法语义规则内隐习得情况。我们将人工汉字中嵌入的词根的语义一致性水平控制在高（100 %）、中等（80 %）和低（60 %）。行为结果表明，8岁的二年级儿童能够习得人工汉字序列中语义词根的规律。ERP结果显示N170-P300-N400模式。枕颞区的N170成分反映了早期正字法识别，而P300和N400成分反映了后期正字法-语义连接统计学习的注意分配和语义激活。7-11岁儿童统计学习的神经激活与年级之间的相互作用显示了显著的发展变化。这些发现支持了统计学习的多成分模型和年龄相关假说。

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引用次数: 0

Parental substance use history density and its influence on reward anticipation brain activation in late childhood and early adolescence 父母物质使用史密度及其对儿童晚期和青少年早期奖赏预期脑激活的影响

IF 4.6 2区医学 Q1 NEUROSCIENCES

Developmental Cognitive Neuroscience

Pub Date : 2025-05-28 DOI: 10.1016/j.dcn.2025.101572

Gabriella Y. Navarro-Love , Elizabeth A. Stinson , Ryan M. Sullivan , Krista M. Lisdahl

Parental history of problematic substance use (PH) increases the risk for early adolescent substance use (SU), potentially due to premorbid differences in reward-processing brain regions (e.g., striatum). However, no studies have prospectively examined the separate contributions of parental history of alcohol (PHA) and drug (PHD) use or the impact of PH density (PH⁰, PH¹, PH²) on reward processing in preadolescents. This study analyzed data from 10,235 participants (ages 9–14) in the Adolescent Brain Cognitive Development Study^SM (ABCD). Reward processing was assessed using the Monetary Incentive Delay Task (MID) at baseline and two-year follow-up. Regions of interest included bilateral striatal activation elicited by neutral vs. anticipation of large rewards. Linear mixed-effect models evaluated PH, PHA, PHD, and PH density on ROI activation, controlling for relevant covariates. Results showed that youth with PHA¹ had greater nucleus accumbens activation during reward anticipation than those with no history (PHA⁰), but no significant differences were found between PHA² and PHA¹ or PHA² and PHA⁰. PHD and PH were not significantly associated with BOLD activation in striatal regions, nor were there changes over time. These findings highlight the need to consider both PH and environmental factors when assessing neurodevelopmental risk for early substance use.

父母有问题物质使用史（PH）会增加青少年早期物质使用（SU）的风险，这可能是由于发病前大脑奖励处理区域（如纹状体）的差异。然而，目前还没有研究前瞻性地考察父母酒精（PHA）和药物（PHD）使用史或PH密度（PH0, PH1, PH2）对青春期前奖励加工的影响。这项研究分析了青少年大脑认知发展研究（ABCD）中10235名参与者（9-14岁）的数据。在基线和两年的随访中，使用货币激励延迟任务（MID）评估奖励处理。感兴趣的区域包括双侧纹状体激活，由中性和预期的大奖励引起。线性混合效应模型评估了PH、PHA、PHD和PH密度对ROI激活的影响，控制了相关协变量。结果显示，有PHA1的青年比没有PHA0的青年在奖赏预期时伏隔核的激活更大，但PHA2与PHA1或PHA2与PHA0之间没有显著差异。PHD和PH与纹状体区域的BOLD激活没有显著相关，也没有随时间的变化。这些发现强调，在评估早期药物使用的神经发育风险时，需要考虑PH和环境因素。

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