Nutrition Metabolism and Cardiovascular Diseases最新文献_第8页

Trends and disability-attributable risk factors of type 2 diabetes mellitus in Southeast Asia (1990–2019): An in-depth 30-year analysis from the Global Burden of Disease study 东南亚 2 型糖尿病的趋势和致残风险因素（1990-2019 年）：全球疾病负担研究的 30 年深入分析。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2024-09-30 DOI: 10.1016/j.numecd.2024.09.020

Annisa Salsabilla Dwi Nugrahani , Farizal Rizky Muharram , Hermina Novida , Julian Benedict Swannjo , Sony Wibisono , Citrawati Dyah Kencono Wungu

Background and aims

To provide insight on targeted approach to mitigate diabetes burden, this research aims to analyze the trends of prevalence, mortality, and disability attributable to risk factors for type 2 diabetes mellitus (T2DM) from 1990 to 2019 in the Southeast Asia (SEA) region.

Methods and results

Age-standardized rates for prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) from 1990 to 2019 from the Global Burden of Disease Study were assessed. DALYs-related risk factors were estimated using multivariate regression analysis and estimated annual percentage change (EAPC) was calculated to quantify the temporal trends. Over 30 years, the SEA region experienced a 59.5 % rise in T2DM ASPR, 17.33 % in ASMR, and 26.97 % in DALYs. The T2DM DALYs rate per 100,000 population was 1002.91 (885.23–1132.40) in 1990 and 1273.42 (1103.92–1452.41) in 2019, increasing by 27 %. Cambodia and Indonesia had the highest worsening in three parameters, while most significant improvement in all parameters was observed in Singapore. The curvilinear association was demonstrated between ASMR and DALYs to Gross Domestic Product (GDP) per capita. Prominent risk factors affecting DALYs increase were high fasting plasma glucose (FPG) (p < 0.001), high body mass index (BMI) (p < 0.001), tobacco use (p = 0.012), and household pollution (p = 0.03). Men were more affected than women.

Conclusion

The burden of T2DM in the SEA region has increased significantly during the 30-year period. Policymakers should address high BMI, high FPG, smoking, and air pollution to regulate T2DM burden in SEA.

背景和目的：为深入了解减轻糖尿病负担的针对性方法，本研究旨在分析东南亚（SEA）地区1990年至2019年2型糖尿病（T2DM）风险因素导致的患病率、死亡率和残疾率的变化趋势：评估了全球疾病负担研究（Global Burden of Disease Study）中1990年至2019年的患病率（ASPR）、死亡率（ASMR）和残疾调整生命年（DALYs）的年龄标准化比率。使用多元回归分析估算了与残疾调整生命年相关的风险因素，并计算了估计年度百分比变化（EAPC），以量化时间趋势。30 年间，东南亚地区的 T2DM ASPR 上升了 59.5%，ASMR 上升了 17.33%，DALYs 上升了 26.97%。1990 年，每 10 万人中 T2DM DALYs 的比率为 1002.91（885.23-1132.40），2019 年为 1273.42（1103.92-1452.41），增加了 27%。柬埔寨和印度尼西亚的三个参数恶化幅度最大，而新加坡所有参数的改善幅度最大。ASMR与人均国内生产总值（GDP）的DALYs之间呈曲线关系。影响残疾调整寿命年数增加的主要风险因素是空腹血浆葡萄糖（FPG）过高（p）：东南亚地区的 T2DM 负担在 30 年间显著增加。决策者应解决高体重指数、高空腹血浆葡萄糖、吸烟和空气污染等问题，以控制东南亚地区的 T2DM 负担。

{"title":"Trends and disability-attributable risk factors of type 2 diabetes mellitus in Southeast Asia (1990–2019): An in-depth 30-year analysis from the Global Burden of Disease study","authors":"Annisa Salsabilla Dwi Nugrahani , Farizal Rizky Muharram , Hermina Novida , Julian Benedict Swannjo , Sony Wibisono , Citrawati Dyah Kencono Wungu","doi":"10.1016/j.numecd.2024.09.020","DOIUrl":"10.1016/j.numecd.2024.09.020","url":null,"abstract":"<div><h3>Background and aims</h3><div>To provide insight on targeted approach to mitigate diabetes burden, this research aims to analyze the trends of prevalence, mortality, and disability attributable to risk factors for type 2 diabetes mellitus (T2DM) from 1990 to 2019 in the Southeast Asia (SEA) region.</div></div><div><h3>Methods and results</h3><div>Age-standardized rates for prevalence (ASPR), mortality (ASMR), and disability-adjusted life years (DALYs) from 1990 to 2019 from the Global Burden of Disease Study were assessed. DALYs-related risk factors were estimated using multivariate regression analysis and estimated annual percentage change (EAPC) was calculated to quantify the temporal trends. Over 30 years, the SEA region experienced a 59.5 % rise in T2DM ASPR, 17.33 % in ASMR, and 26.97 % in DALYs. The T2DM DALYs rate per 100,000 population was 1002.91 (885.23–1132.40) in 1990 and 1273.42 (1103.92–1452.41) in 2019, increasing by 27 %. Cambodia and Indonesia had the highest worsening in three parameters, while most significant improvement in all parameters was observed in Singapore. The curvilinear association was demonstrated between ASMR and DALYs to Gross Domestic Product (GDP) per capita. Prominent risk factors affecting DALYs increase were high fasting plasma glucose (FPG) (p < 0.001), high body mass index (BMI) (p < 0.001), tobacco use (p = 0.012), and household pollution (p = 0.03). Men were more affected than women.</div></div><div><h3>Conclusion</h3><div>The burden of T2DM in the SEA region has increased significantly during the 30-year period. Policymakers should address high BMI, high FPG, smoking, and air pollution to regulate T2DM burden in SEA.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 1","pages":"Article 103750"},"PeriodicalIF":3.3,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adverse event reporting of combining SGLT2 inhibitor and GLP1 receptor agonist: A real-world study from FAERS 联合使用 SGLT2 抑制剂和 GLP1 受体激动剂的不良事件报告：来自 FAERS 的真实世界研究。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2024-09-27 DOI: 10.1016/j.numecd.2024.09.028

Chunyan Tian, Zheng Yang, Subei Zhao, Ping Zhang, Rong Li

Background and aims

We evaluate whether the combination of sodium-glucose cotransporter-2 inhibitor(SGLT2i) and glucagon-like peptide-1 receptor agonist(GLP1RA) disproportionally increases the reporting of adverse events compared with SGLT2i or GLP1RA monotherapy in the FDA adverse event reporting system (FAERS).

Methods and results

Adverse events related to SGLT2i and GLP1RA were screened and selected, then data from the FAERS was underwent thorough disproportionality analysis. The proportional reporting ratio(PRR) of SGLT2i-related adverse events were compared between patients using SGLT2i alone and those using both SGLT2i and GLP1RA. Similarly, the PRR of GLP1RA-related adverse events were compared between patients using GLP1RA alone and those using both SGLT2i and GLP1RA. The results showed that the PRR of SGLT2i-related adverse events including diabetic ketoacidosis(DKA), ketosis, reproductive tract adverse events, urinary tract infection, and other adverse events, decreased in individuals using both SGLT2i and GLP1RA compared with those using SGLT2i alone, and the signal of fracture was not detected. Likewise, the PRR of GLP1RA-related adverse events including gastrointestinal adverse events, gallbladder and biliary tract disease, pancreatitis, and other adverse events, decreased in individuals using both SGLT2i and GLP1RA compared with those using GLP1RA alone, the PRR of hyperlipasaemia and hyperamylasaemia increased in the combination therapy and no signal of depression, suicidal and self-injurious behaviour was detected.

Conclusion

Adverse events reporting are not disproportionally higher among those using both SGLT-2i and GLP1RA compared with SGLT2i or GLP1RA monotherapy.

背景和目的：我们评估了在美国食品药品管理局不良事件报告系统（FAERS）中，钠-葡萄糖共转运体-2抑制剂（SGLT2i）和胰高血糖素样肽-1受体激动剂（GLP1RA）的联合治疗与SGLT2i或GLP1RA单药治疗相比是否会不成比例地增加不良事件的报告：筛选出与 SGLT2i 和 GLP1RA 相关的不良事件，然后对来自 FAERS 的数据进行全面的比例失调分析。比较了单独使用 SGLT2i 和同时使用 SGLT2i 和 GLP1RA 的患者发生 SGLT2i 相关不良事件的比例报告比（PRR）。同样，比较了单独使用 GLP1RA 的患者与同时使用 SGLT2i 和 GLP1RA 的患者之间 GLP1RA 相关不良事件的 PRR。结果显示，与单独使用 SGLT2i 的患者相比，同时使用 SGLT2i 和 GLP1RA 的患者发生 SGLT2i 相关不良事件（包括糖尿病酮症酸中毒（DKA）、酮症酸中毒、生殖道不良事件、尿路感染和其他不良事件）的 PRR 均有所下降，且未发现骨折信号。同样，与单独使用 GLP1RA 的患者相比，同时使用 SGLT2i 和 GLP1RA 的患者发生 GLP1RA 相关不良事件（包括胃肠道不良事件、胆囊和胆道疾病、胰腺炎和其他不良事件）的 PRR 有所下降，联合疗法中发生高脂血症和高淀粉血症的 PRR 有所上升，未发现抑郁、自杀和自伤行为的信号：结论：与 SGLT2i 或 GLP1RA 单药治疗相比，同时使用 SGLT-2i 和 GLP1RA 的患者报告的不良事件并没有不成比例地增加。

{"title":"Adverse event reporting of combining SGLT2 inhibitor and GLP1 receptor agonist: A real-world study from FAERS","authors":"Chunyan Tian, Zheng Yang, Subei Zhao, Ping Zhang, Rong Li","doi":"10.1016/j.numecd.2024.09.028","DOIUrl":"10.1016/j.numecd.2024.09.028","url":null,"abstract":"<div><h3>Background and aims</h3><div>We evaluate whether the combination of sodium-glucose cotransporter-2 inhibitor(SGLT2i) and glucagon-like peptide-1 receptor agonist(GLP1RA) disproportionally increases the reporting of adverse events compared with SGLT2i or GLP1RA monotherapy in the FDA adverse event reporting system (FAERS).</div></div><div><h3>Methods and results</h3><div>Adverse events related to SGLT2i and GLP1RA were screened and selected, then data from the FAERS was underwent thorough disproportionality analysis. The proportional reporting ratio(PRR) of SGLT2i-related adverse events were compared between patients using SGLT2i alone and those using both SGLT2i and GLP1RA. Similarly, the PRR of GLP1RA-related adverse events were compared between patients using GLP1RA alone and those using both SGLT2i and GLP1RA. The results showed that the PRR of SGLT2i-related adverse events including diabetic ketoacidosis(DKA), ketosis, reproductive tract adverse events, urinary tract infection, and other adverse events, decreased in individuals using both SGLT2i and GLP1RA compared with those using SGLT2i alone, and the signal of fracture was not detected. Likewise, the PRR of GLP1RA-related adverse events including gastrointestinal adverse events, gallbladder and biliary tract disease, pancreatitis, and other adverse events, decreased in individuals using both SGLT2i and GLP1RA compared with those using GLP1RA alone, the PRR of hyperlipasaemia and hyperamylasaemia increased in the combination therapy and no signal of depression, suicidal and self-injurious behaviour was detected.</div></div><div><h3>Conclusion</h3><div>Adverse events reporting are not disproportionally higher among those using both SGLT-2i and GLP1RA compared with SGLT2i or GLP1RA monotherapy.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"35 1","pages":"Article 103758"},"PeriodicalIF":3.3,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison between Friedewald's and Sampson's formulas in the estimation of high levels of measured LDL-cholesterol in youth with obesity. 比较弗里德瓦尔德公式和桑普森公式对肥胖症青少年高水平低密度脂蛋白胆固醇测量值的估算。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2024-09-26 DOI: 10.1016/j.numecd.2024.09.023

Procolo Di Bonito, Domenico Corica, Malgorzata Gabriela Wasniewska, Anna Di Sessa, Emanuele Miraglia Del Giudice, Maria Rosaria Licenziati, Nicola Improda, Giuliana Valerio

Background and aim: To assess the performance of Friedewald's and Sampson's formulas in relation to high or borderline-high levels of measured LDL-Cholesterol (LDL-C) in youths with overweight/obesity (OW/OB).

Methods and results: A cross-sectional study was performed in 1694 youths (age 5-17 years) with OW/OB observed in Italian centers of Messina (group 1) and Naples (group 2). LDL-C levels were both measured and calculated using Friedewald's (LDL-C_F) and Sampson's (LDL-C_S) formulas. The two groups were similar for sex, age, BMI, BMI Z-score, and measured LDL-C. Levels of LDL-C_F and LDL-C_S were higher in group 1 than group 2. In the overall sample, 9.9 % youths had measured LDL-C ≥130 mg/dL and 27.8 % ≥ 110 mg/dL, without differences between centers. The two formulas showed comparable high sensitivity and specificity in relation to levels of measured LDL-C ≥130 mg/dL or ≥110 mg/dL. However, LDL-C_F showed a higher positive predictive value than LDL-C_S.

Conclusions: Both formulas estimate with high accuracy measured LDL-C levels in youths with OW/OB. Therefore, calculated LDL-C can be a useful tool for universal screening when direct LDL-C measurement is not available. The Friedewald's formula is more feasible in clinical practice for simplicity of calculation.

背景和目的：评估弗里德瓦尔德（Friedewald）公式和桑普森（Sampson）公式在超重/肥胖（OW/OB）青少年高水平或接近高水平低密度脂蛋白胆固醇（LDL-C）测量中的表现：在意大利墨西拿（第1组）和那不勒斯（第2组）的中心对1694名超重/肥胖青少年（5-17岁）进行了横断面研究。采用弗里德瓦尔德（LDL-CF）和桑普森（LDL-CS）公式测量和计算了低密度脂蛋白胆固醇水平。两组的性别、年龄、体重指数、体重指数 Z 值和测量的低密度脂蛋白胆固醇水平相似。第一组的 LDL-CF 和 LDL-CS 水平高于第二组。在所有样本中，9.9% 的青少年测量的 LDL-C≥130 毫克/分升，27.8% 的青少年测量的 LDL-C≥110 毫克/分升，各中心之间没有差异。这两种公式对测量的低密度脂蛋白胆固醇水平≥130 毫克/分升或≥110 毫克/分升显示出相当高的灵敏度和特异性。然而，LDL-CF 的阳性预测值高于 LDL-CS：结论：两种计算公式都能非常准确地估算出 OW/OB 青少年的测量低密度脂蛋白胆固醇水平。因此，在无法直接测量低密度脂蛋白胆固醇的情况下，计算出的低密度脂蛋白胆固醇可作为一种有用的工具用于普遍筛查。在临床实践中，弗里德瓦尔德公式因计算简便而更为可行。

{"title":"Comparison between Friedewald's and Sampson's formulas in the estimation of high levels of measured LDL-cholesterol in youth with obesity.","authors":"Procolo Di Bonito, Domenico Corica, Malgorzata Gabriela Wasniewska, Anna Di Sessa, Emanuele Miraglia Del Giudice, Maria Rosaria Licenziati, Nicola Improda, Giuliana Valerio","doi":"10.1016/j.numecd.2024.09.023","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.023","url":null,"abstract":"<p><strong>Background and aim: </strong>To assess the performance of Friedewald's and Sampson's formulas in relation to high or borderline-high levels of measured LDL-Cholesterol (LDL-C) in youths with overweight/obesity (OW/OB).</p><p><strong>Methods and results: </strong>A cross-sectional study was performed in 1694 youths (age 5-17 years) with OW/OB observed in Italian centers of Messina (group 1) and Naples (group 2). LDL-C levels were both measured and calculated using Friedewald's (LDL-C<sub>F</sub>) and Sampson's (LDL-C<sub>S</sub>) formulas. The two groups were similar for sex, age, BMI, BMI Z-score, and measured LDL-C. Levels of LDL-C<sub>F</sub> and LDL-C<sub>S</sub> were higher in group 1 than group 2. In the overall sample, 9.9 % youths had measured LDL-C ≥130 mg/dL and 27.8 % ≥ 110 mg/dL, without differences between centers. The two formulas showed comparable high sensitivity and specificity in relation to levels of measured LDL-C ≥130 mg/dL or ≥110 mg/dL. However, LDL-C<sub>F</sub> showed a higher positive predictive value than LDL-C<sub>S</sub>.</p><p><strong>Conclusions: </strong>Both formulas estimate with high accuracy measured LDL-C levels in youths with OW/OB. Therefore, calculated LDL-C can be a useful tool for universal screening when direct LDL-C measurement is not available. The Friedewald's formula is more feasible in clinical practice for simplicity of calculation.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum uric acid and mortality in metabolic dysfunction-associated steatotic liver disease: Subgroup differences 代谢功能障碍相关脂肪性肝病患者的血清尿酸与死亡率：亚组差异。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2024-09-21 DOI: 10.1016/j.numecd.2024.09.015

Wenya Chen , You Deng , Mengqi Li , Jiashuo Li , Ying Cao , Wen Xie

Background and aims

This study aims to investigate the association between serum uric acid (SUA) and both the risk and long-term mortality of dysfunction-associated steatotic liver disease (MASLD), and to explore differences between the pure MASLD and metabolic and alcohol related/associated liver disease (MetALD) subgroups.

Methods and results

We included 11,675 participants from the Third National Health and Nutrition Examination Survey, with matched mortality data up to 2019. Logistic regression and Cox proportional hazards regression evaluated the relationship between SUA and both the risk and mortality of MASLD. Non-linear correlations and threshold effects were explored using restricted cubic splines and a two-piecewise Cox proportional hazards model. We found that SUA was positively associated with the risk of MASLD [odds ratio (OR): 1.19, 95 % confidence interval (CI) 1.12–1.27]. For pure MASLD, SUA showed a positive association with all-cause mortality [<4.7 mg/dL: hazard ratio (HR): 1.34, 95 % CI 1.04–1.73; ≥4.7 mg/dL: HR: 1.08, 95 % CI 1.02–1.15] and cardiovascular mortality (HR: 1.12, 95 % CI 1.02–1.22). For MetALD, there was an inverse J-shaped relationship (threshold: 6.6 mg/dL) between SUA and all-cause mortality. Below the threshold, SUA was negatively correlated with all-cause mortality (HR: 0.42, 95 % CI 0.19–0.93), but no association was found above it (HR: 0.81, 95 % CI 0.54–1.21). Additionally, no association was observed between SUA and cardiovascular mortality.

Conclusions

SUA serves as an independent predictor of the risk and all-cause mortality of MASLD. The relationship between SUA and both all-cause and cardiovascular mortality differs between the pure MASLD and MetALD subgroups.

背景和目的：本研究旨在调查血清尿酸（SUA）与功能障碍相关性脂肪性肝病（MASLD）的风险和长期死亡率之间的关系，并探讨纯MASLD亚组与代谢和酒精相关/相关性肝病（MetALD）亚组之间的差异：我们纳入了来自第三次全国健康与营养调查的 11,675 名参与者，并提供了截至 2019 年的匹配死亡率数据。逻辑回归和 Cox 比例危险度回归评估了 SUA 与 MASLD 风险和死亡率之间的关系。我们使用限制性三次样条和双片式 Cox 比例危险模型探讨了非线性相关性和阈值效应。我们发现，SUA 与罹患 MASLD 的风险呈正相关[比值比 (OR)：1.19，95% 置信区间 (CI) 1.12-1.27]。对于纯 MASLD，SUA 与全因死亡率呈正相关[结论：SUA是MASLD风险和全因死亡率的独立预测因子。SUA与全因死亡率和心血管死亡率之间的关系在纯MASLD亚组和MetALD亚组之间有所不同。

{"title":"Serum uric acid and mortality in metabolic dysfunction-associated steatotic liver disease: Subgroup differences","authors":"Wenya Chen , You Deng , Mengqi Li , Jiashuo Li , Ying Cao , Wen Xie","doi":"10.1016/j.numecd.2024.09.015","DOIUrl":"10.1016/j.numecd.2024.09.015","url":null,"abstract":"<div><h3>Background and aims</h3><div>This study aims to investigate the association between serum uric acid (SUA) and both the risk and long-term mortality of dysfunction-associated steatotic liver disease (MASLD), and to explore differences between the pure MASLD and metabolic and alcohol related/associated liver disease (MetALD) subgroups.</div></div><div><h3>Methods and results</h3><div>We included 11,675 participants from the Third National Health and Nutrition Examination Survey, with matched mortality data up to 2019. Logistic regression and Cox proportional hazards regression evaluated the relationship between SUA and both the risk and mortality of MASLD. Non-linear correlations and threshold effects were explored using restricted cubic splines and a two-piecewise Cox proportional hazards model. We found that SUA was positively associated with the risk of MASLD [odds ratio (OR): 1.19, 95 % confidence interval (CI) 1.12–1.27]. For pure MASLD, SUA showed a positive association with all-cause mortality [<4.7 mg/dL: hazard ratio (HR): 1.34, 95 % CI 1.04–1.73; ≥4.7 mg/dL: HR: 1.08, 95 % CI 1.02–1.15] and cardiovascular mortality (HR: 1.12, 95 % CI 1.02–1.22). For MetALD, there was an inverse J-shaped relationship (threshold: 6.6 mg/dL) between SUA and all-cause mortality. Below the threshold, SUA was negatively correlated with all-cause mortality (HR: 0.42, 95 % CI 0.19–0.93), but no association was found above it (HR: 0.81, 95 % CI 0.54–1.21). Additionally, no association was observed between SUA and cardiovascular mortality.</div></div><div><h3>Conclusions</h3><div>SUA serves as an independent predictor of the risk and all-cause mortality of MASLD. The relationship between SUA and both all-cause and cardiovascular mortality differs between the pure MASLD and MetALD subgroups.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"34 12","pages":"Pages 2771-2778"},"PeriodicalIF":3.3,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel metabolic indicators and the risk of cardiovascular disease in patients with hypertension: A primary-care cohort study. 新的代谢指标与高血压患者罹患心血管疾病的风险：一项初级保健队列研究。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2024-09-21 DOI: 10.1016/j.numecd.2024.09.019

Deliang Lv, Zhen Liu, Xiaobing Wu, Fengzhu Xie, Qinggang Shang, Wei Xie, Ziyang Zhang, Zhiguang Zhao

Background and aims: Data are limited on whether several easily measured indices serve as effective tools for Cardiovascular disease (CVD) risk assessment in hypertensive patients. This study aimed to assess the associations of metabolic score for insulin resistance (METS-IR), lipid accumulation product (LAP), and visceral adiposity index (VAI) with CVD risk in hypertensive patients.

Methods and results: Our data were drawn from the medical records of primary-care institutions in China. The present study included 306,680 individuals with hypertension attending primary healthcare centers. Cox regression analyses were applied to assess the associations of novel metabolic indicators with the risk of CVD. During a median follow-up of 1.98 years, 5820 participants developed CVD. When comparing with the lowest quartile of the indices, the highest quartile of METS-IR, LAP, and VAI was associated with 1.25-fold (95 % CI: 1.16-1.35), 1.15-fold (95 % CI: 1.05-1.25), and 1.19-fold (95 % CI: 1.10-1.28) risk of CVD after adjusting for potential confounders.

Conclusion: This study provided additional evidence that novel metabolic indicators like METS-IR, LAP, and VAI were associated with the risk of CVD. These results suggest that proactive assessment of visceral adiposity and insulin resistance could be helpful for the effective clinical management of the hypertensive population.

背景和目的：关于几种易于测量的指数是否可作为高血压患者心血管疾病（CVD）风险评估的有效工具，相关数据十分有限。本研究旨在评估胰岛素抵抗代谢评分（METS-IR）、脂质累积乘积（LAP）和内脏脂肪指数（VAI）与高血压患者心血管疾病风险的关联：我们的数据来自中国基层医疗机构的医疗记录。本研究纳入了 306 680 名在基层医疗机构就诊的高血压患者。采用 Cox 回归分析评估了新的代谢指标与心血管疾病风险的相关性。在1.98年的中位随访期间，5820名参与者发生了心血管疾病。与指数最低四分位数相比，调整潜在混杂因素后，METS-IR、LAP和VAI的最高四分位数分别与1.25倍（95 % CI：1.16-1.35）、1.15倍（95 % CI：1.05-1.25）和1.19倍（95 % CI：1.10-1.28）的心血管疾病风险相关：本研究提供了更多证据，证明METS-IR、LAP和VAI等新型代谢指标与心血管疾病风险相关。这些结果表明，主动评估内脏脂肪和胰岛素抵抗有助于对高血压人群进行有效的临床管理。

{"title":"Novel metabolic indicators and the risk of cardiovascular disease in patients with hypertension: A primary-care cohort study.","authors":"Deliang Lv, Zhen Liu, Xiaobing Wu, Fengzhu Xie, Qinggang Shang, Wei Xie, Ziyang Zhang, Zhiguang Zhao","doi":"10.1016/j.numecd.2024.09.019","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.019","url":null,"abstract":"<p><strong>Background and aims: </strong>Data are limited on whether several easily measured indices serve as effective tools for Cardiovascular disease (CVD) risk assessment in hypertensive patients. This study aimed to assess the associations of metabolic score for insulin resistance (METS-IR), lipid accumulation product (LAP), and visceral adiposity index (VAI) with CVD risk in hypertensive patients.</p><p><strong>Methods and results: </strong>Our data were drawn from the medical records of primary-care institutions in China. The present study included 306,680 individuals with hypertension attending primary healthcare centers. Cox regression analyses were applied to assess the associations of novel metabolic indicators with the risk of CVD. During a median follow-up of 1.98 years, 5820 participants developed CVD. When comparing with the lowest quartile of the indices, the highest quartile of METS-IR, LAP, and VAI was associated with 1.25-fold (95 % CI: 1.16-1.35), 1.15-fold (95 % CI: 1.05-1.25), and 1.19-fold (95 % CI: 1.10-1.28) risk of CVD after adjusting for potential confounders.</p><p><strong>Conclusion: </strong>This study provided additional evidence that novel metabolic indicators like METS-IR, LAP, and VAI were associated with the risk of CVD. These results suggest that proactive assessment of visceral adiposity and insulin resistance could be helpful for the effective clinical management of the hypertensive population.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-specific association of weight-adjusted waist index with mortality in stroke survivors: A national longitudinal cohort study. 体重调整后腰围指数与中风幸存者死亡率的性别特异性关联：一项全国纵向队列研究。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2024-09-19 DOI: 10.1016/j.numecd.2024.09.013

Fei Liu, Jiarui Chen, Ying Yao, Reng Ren, Yue Yu, Yinghong Hu

Background and aims: The weight-adjusted waist index (WWI) is a novel indicator of obesity, and its association with mortality in stroke patients remains unknown. We aimed to explore these associations through a national longitudinal cohort study.

Methods and results: We included stroke survivors from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 who were followed up until December 31, 2019. The study outcomes were all-cause and cardiovascular disease (CVD) mortality in stroke patients. A total of 1427 stroke patients were enrolled, and after a median follow-up duration of 83 months, 624 stroke patients died, including 251 from CVD. Kaplan‒Meier survival analyses indicated that WWI was significantly associated with the probability of survival over time in stroke patients (log-rank tests, both p < 0.0001). After adjusting for confounders, WWI was significantly and positively associated with all-cause and CVD mortality after stroke. Restricted cubic spline analysis revealed that WWI was linearly associated with all-cause mortality and nonlinearly associated with CVD mortality. Stratified analyses suggested that sex significantly influenced the effect of WWI on all-cause mortality in stroke patients. Additional body mass index (BMI) adjustments did not significantly change the results.

Conclusion: WWI was positively associated with all-cause and CVD mortality in stroke patients, independent of BMI. These effects were present only in men. These findings suggest that WWI is an independent prognostic factor in stroke patients and that maintaining appropriate WWI values can help improve the prognosis of stroke survivors.

背景和目的：体重调整腰围指数（WWI）是一项新的肥胖指标，其与中风患者死亡率的关系尚不清楚。我们旨在通过一项全国纵向队列研究来探讨这些关联：我们纳入了 1999-2018 年美国国家健康与营养调查（NHANES）中的中风幸存者，对他们进行了随访，直至 2019 年 12 月 31 日。研究结果为中风患者的全因死亡率和心血管疾病（CVD）死亡率。共有 1427 名中风患者入选，经过中位 83 个月的随访，624 名中风患者死亡，其中 251 人死于心血管疾病。卡普兰-梅耶生存分析表明，WWI 与中风患者的存活概率有显著相关性（对数秩检验，均为 p 结论：WWI 与中风患者的全部死亡率呈正相关：WWI与中风患者的全因死亡率和心血管疾病死亡率呈正相关，与体重指数无关。这些影响仅存在于男性中。这些研究结果表明，WWI 是脑卒中患者的一个独立预后因素，保持适当的 WWI 值有助于改善脑卒中幸存者的预后。

{"title":"Sex-specific association of weight-adjusted waist index with mortality in stroke survivors: A national longitudinal cohort study.","authors":"Fei Liu, Jiarui Chen, Ying Yao, Reng Ren, Yue Yu, Yinghong Hu","doi":"10.1016/j.numecd.2024.09.013","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.013","url":null,"abstract":"<p><strong>Background and aims: </strong>The weight-adjusted waist index (WWI) is a novel indicator of obesity, and its association with mortality in stroke patients remains unknown. We aimed to explore these associations through a national longitudinal cohort study.</p><p><strong>Methods and results: </strong>We included stroke survivors from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 who were followed up until December 31, 2019. The study outcomes were all-cause and cardiovascular disease (CVD) mortality in stroke patients. A total of 1427 stroke patients were enrolled, and after a median follow-up duration of 83 months, 624 stroke patients died, including 251 from CVD. Kaplan‒Meier survival analyses indicated that WWI was significantly associated with the probability of survival over time in stroke patients (log-rank tests, both p < 0.0001). After adjusting for confounders, WWI was significantly and positively associated with all-cause and CVD mortality after stroke. Restricted cubic spline analysis revealed that WWI was linearly associated with all-cause mortality and nonlinearly associated with CVD mortality. Stratified analyses suggested that sex significantly influenced the effect of WWI on all-cause mortality in stroke patients. Additional body mass index (BMI) adjustments did not significantly change the results.</p><p><strong>Conclusion: </strong>WWI was positively associated with all-cause and CVD mortality in stroke patients, independent of BMI. These effects were present only in men. These findings suggest that WWI is an independent prognostic factor in stroke patients and that maintaining appropriate WWI values can help improve the prognosis of stroke survivors.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing the lifestyle of patients with type 2 diabetes mellitus - Systematic review on the effects of combined diet-and-exercise interventions. 优化 2 型糖尿病患者的生活方式--饮食与运动相结合干预效果的系统回顾。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2024-09-19 DOI: 10.1016/j.numecd.2024.09.016

Jessica Amerkamp, Süleyman Benli, Eduard Isenmann, Christian Brinkmann

Aim: To investigate the effects of combined diet-and-exercise interventions in patients with type 2 diabetes mellitus (T2DM).

Data synthesis: A systematic literature search was conducted on PubMed, Web of Science, SPORTDiscus and BISp Surf databases (latest update in June 2024). A total of 14706 records was identified. After screening procedures, 11 randomized controlled trials (n = 24 reports) were included. The included studies compared either the effects of a) a combined intervention versus a diet-only intervention or b) different combinations of diet and exercise. The overall quality of the included study reports was moderate (evaluated with the Risk of Bias 2 (RoB2) tool). Effects of adding exercise to a (calorie-restricted) diet were primarily reflected in increased physical fitness/performance. In far fewer cases, additional beneficial effects on glycemic control, number of subjects taking medication, body weight, body composition, or lipid profile were reported. Combined with regular exercise, an energy-restricted low-carbohydrate (LC) diet with either high-fat (HF) or high-protein (HP) contents showed superior effects compared with an energy-matched conventional (CONV) diet in terms of improvements in medication use (HF-LC versus CONV diet), lipids (HF-LC or HP-LC versus CONV diet) or wellbeing (HP-LC versus CONV diet) in some studies.

Conclusions: Complementing a dietary intervention with regular exercise can have additional health benefits in T2DM, specifically improved physical fitness/performance. LC diets might be superior to other diets when combined with regular exercise. Other diet-and-exercise combinations than those analyzed in this review need to be investigated.

Review registration number: CRD42023458830.

目的：研究饮食与运动相结合的干预措施对 2 型糖尿病（T2DM）患者的影响：在 PubMed、Web of Science、SPORTDiscus 和 BISp Surf 数据库（最新更新时间为 2024 年 6 月）上进行了系统性文献检索。共检索到 14706 条记录。经过筛选，共纳入 11 项随机对照试验（n = 24 份报告）。纳入的研究比较了 a) 综合干预与单纯饮食干预或 b) 饮食与运动不同组合的效果。纳入研究报告的总体质量为中等（使用偏倚风险 2 (RoB2) 工具进行评估）。在（限制卡路里）饮食的基础上增加运动的效果主要体现在体能/表现的提高上。报告对血糖控制、服药人数、体重、身体成分或血脂状况产生额外有益影响的案例要少得多。在一些研究中，与能量匹配的常规（CONV）饮食相比，能量限制的高脂肪（HF）或高蛋白（HP）低碳水化合物（LC）饮食与定期锻炼相结合，在改善用药（HF-LC 与 CONV 饮食相比）、血脂（HF-LC 或 HP-LC 与 CONV 饮食相比）或健康（HP-LC 与 CONV 饮食相比）方面显示出更优越的效果：结论：对 T2DM 患者进行饮食干预并辅以定期锻炼可带来额外的健康益处，尤其是改善体能/表现。低脂饮食与定期运动相结合可能优于其他饮食。除本综述分析的饮食和运动组合外，还需要对其他饮食和运动组合进行研究：CRD42023458830。

{"title":"Optimizing the lifestyle of patients with type 2 diabetes mellitus - Systematic review on the effects of combined diet-and-exercise interventions.","authors":"Jessica Amerkamp, Süleyman Benli, Eduard Isenmann, Christian Brinkmann","doi":"10.1016/j.numecd.2024.09.016","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.016","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the effects of combined diet-and-exercise interventions in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Data synthesis: </strong>A systematic literature search was conducted on PubMed, Web of Science, SPORTDiscus and BISp Surf databases (latest update in June 2024). A total of 14706 records was identified. After screening procedures, 11 randomized controlled trials (n = 24 reports) were included. The included studies compared either the effects of a) a combined intervention versus a diet-only intervention or b) different combinations of diet and exercise. The overall quality of the included study reports was moderate (evaluated with the Risk of Bias 2 (RoB2) tool). Effects of adding exercise to a (calorie-restricted) diet were primarily reflected in increased physical fitness/performance. In far fewer cases, additional beneficial effects on glycemic control, number of subjects taking medication, body weight, body composition, or lipid profile were reported. Combined with regular exercise, an energy-restricted low-carbohydrate (LC) diet with either high-fat (HF) or high-protein (HP) contents showed superior effects compared with an energy-matched conventional (CONV) diet in terms of improvements in medication use (HF-LC versus CONV diet), lipids (HF-LC or HP-LC versus CONV diet) or wellbeing (HP-LC versus CONV diet) in some studies.</p><p><strong>Conclusions: </strong>Complementing a dietary intervention with regular exercise can have additional health benefits in T2DM, specifically improved physical fitness/performance. LC diets might be superior to other diets when combined with regular exercise. Other diet-and-exercise combinations than those analyzed in this review need to be investigated.</p><p><strong>Review registration number: </strong>CRD42023458830.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertension induced by peri-pubertal protein restriction depends on renin-angiotensin system dysfunction in adult male rats. 围青春期蛋白质限制诱发的高血压取决于成年雄性大鼠肾素-血管紧张素系统的功能障碍。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2024-09-19 DOI: 10.1016/j.numecd.2024.09.003

Anna Rebeka Oliveira Ferreira, Maiara Vanusa Guedes Ribeiro, Maria Natalia Chimirri Peres, Gabriel Kian Guimarães Lopes, Lucas Paulo Jacinto Saavedra, Silvano Piovan, Leticia Ferreira Barbosa, Scarllet Rodrigues Raposo, Douglas Lopes Almeida, Ananda Malta, Jorge Juarez Vieira Teixeira, Paulo Cezar de Freitas Mathias, Kesia Palma-Rigo

Background and aims: Hypertension depends on renin-angiotensin system dysfunction; however, little is known about its implications in the outcomes of neurogenic hypertension induced by peri-pubertal insults. This study aimed to evaluate whether hypertension induced by a peri-pubertal low-protein diet is related to renin-angiotensin system dysfunction in adult male Wistar rats.

Methods and results: Thirty-day-old male Wistar rats were fed a low-protein diet (4 % casein) for 30 days and subsequently fed a 20.5 % normal protein diet for a 60-day dietary recovery (LP group). Control animals (NP group) were fed a 20.5 % protein diet throughout their lives. Cardiovascular and renin-angiotensin system functions were evaluated on postnatal day 120 (6-24 animals per group). Statistical analyses were performed using the Student's t-test. Animals with LP show increased arterial blood pressure. The angiotensin 2 dose-response curve of LP animals showed an increase in the pressor response at a lower dose (50 ng/kg) and a reduction in the pressor response at a higher dose (400 ng/kg) compared with NP animals. Angiotensin 2 type 1 receptor mRNA levels were increased in the hearts of LP animals; however, angiotensin 2 type 2 receptor and MAS receptor mRNA levels were reduced. In the aorta, AT1 and AT2 mRNA levels were increased in LP animals, whereas MAS receptor mRNA levels were decreased in comparison to NP animals.

Conclusion: The renin-angiotensin system is disrupted in hypertension induced by protein restriction exposure during peri-pubertal life.

背景和目的：高血压取决于肾素-血管紧张素系统功能障碍；然而，人们对其在围青春期损伤诱发的神经源性高血压结果中的影响知之甚少。本研究旨在评估围青春期低蛋白饮食诱发的高血压是否与成年雄性 Wistar 大鼠肾素-血管紧张素系统功能障碍有关：给30天大的雄性Wistar大鼠喂食低蛋白饮食（4%酪蛋白）30天，然后喂食20.5%的正常蛋白饮食，饮食恢复期为60天（LP组）。对照组动物（NP 组）终生食用 20.5 % 蛋白质食物。在出生后第 120 天对心血管和肾素-血管紧张素系统功能进行评估（每组 6-24 只动物）。统计分析采用学生 t 检验。患有 LP 的动物动脉血压升高。与NP动物相比，LP动物的血管紧张素2剂量反应曲线显示，在较低剂量（50纳克/千克）时，加压反应增强，而在较高剂量（400纳克/千克）时，加压反应减弱。LP 动物心脏中血管紧张素 2 1 型受体 mRNA 水平升高，但血管紧张素 2 2 型受体和 MAS 受体 mRNA 水平降低。与 NP 动物相比，LP 动物主动脉中 AT1 和 AT2 mRNA 水平升高，而 MAS 受体 mRNA 水平降低：结论：在围青春期接触蛋白质限制诱发的高血压中，肾素-血管紧张素系统受到破坏。

{"title":"Hypertension induced by peri-pubertal protein restriction depends on renin-angiotensin system dysfunction in adult male rats.","authors":"Anna Rebeka Oliveira Ferreira, Maiara Vanusa Guedes Ribeiro, Maria Natalia Chimirri Peres, Gabriel Kian Guimarães Lopes, Lucas Paulo Jacinto Saavedra, Silvano Piovan, Leticia Ferreira Barbosa, Scarllet Rodrigues Raposo, Douglas Lopes Almeida, Ananda Malta, Jorge Juarez Vieira Teixeira, Paulo Cezar de Freitas Mathias, Kesia Palma-Rigo","doi":"10.1016/j.numecd.2024.09.003","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.003","url":null,"abstract":"<p><strong>Background and aims: </strong>Hypertension depends on renin-angiotensin system dysfunction; however, little is known about its implications in the outcomes of neurogenic hypertension induced by peri-pubertal insults. This study aimed to evaluate whether hypertension induced by a peri-pubertal low-protein diet is related to renin-angiotensin system dysfunction in adult male Wistar rats.</p><p><strong>Methods and results: </strong>Thirty-day-old male Wistar rats were fed a low-protein diet (4 % casein) for 30 days and subsequently fed a 20.5 % normal protein diet for a 60-day dietary recovery (LP group). Control animals (NP group) were fed a 20.5 % protein diet throughout their lives. Cardiovascular and renin-angiotensin system functions were evaluated on postnatal day 120 (6-24 animals per group). Statistical analyses were performed using the Student's t-test. Animals with LP show increased arterial blood pressure. The angiotensin 2 dose-response curve of LP animals showed an increase in the pressor response at a lower dose (50 ng/kg) and a reduction in the pressor response at a higher dose (400 ng/kg) compared with NP animals. Angiotensin 2 type 1 receptor mRNA levels were increased in the hearts of LP animals; however, angiotensin 2 type 2 receptor and MAS receptor mRNA levels were reduced. In the aorta, AT1 and AT2 mRNA levels were increased in LP animals, whereas MAS receptor mRNA levels were decreased in comparison to NP animals.</p><p><strong>Conclusion: </strong>The renin-angiotensin system is disrupted in hypertension induced by protein restriction exposure during peri-pubertal life.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visceral adiposity: A major mediator of the relationship between epicardial adiposity and cardiorespiratory fitness in adults. 内脏脂肪：成年人心外膜脂肪含量与心肺功能之间关系的主要调解因素。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2024-09-19 DOI: 10.1016/j.numecd.2024.09.010

Dominic J Chartrand, Eric Larose, Paul Poirier, Patrick Mathieu, Natalie Alméras, Philippe Pibarot, Benoît Lamarche, Caroline Rhéaume, Isabelle Lemieux, Jean-Pierre Després, Marie-Eve Piché

Background and aims: Epicardial adiposity has been positively associated with visceral adipose tissue (VAT). Few studies have examined the association between cardiorespiratory fitness (CRF) and epicardial adiposity. Furthermore, whether this relationship was independent of VAT remains unexplored. Our purpose was to investigate the contribution of VAT in the relationships between CRF, physical activity (PA) and epicardial adipose tissue (EAT) in asymptomatic women and men.

Methods and results: We examined the associations between EAT and VAT measured by magnetic resonance imaging, CRF measured by cardiopulmonary exercise testing, and PA assessed using pedometers and a 3-day PA journal in 239 apparently healthy adults (43 % women). Participants were compared according to EAT tertiles and CRF level in both sexes. Participants with the highest EAT level presented more VAT (p < 0.001), lower CRF (p < 0.01), and a more deteriorated cardiometabolic health score (p < 0.01) than those with the lowest EAT level. CRF was negatively associated with EAT in both sexes (p < 0.01). No significant relationship was found with PA (p = NS). Stepwise multivariable regression analyses showed that VAT explained most of the variance in EAT in women and men. Mediation analyses confirmed that VAT was a mediator of the association between CRF and EAT in both sexes.

Conclusion: In women and men, VAT appears as a major mediator of the association between CRF and EAT thereby suggesting that managing VAT by improving CRF could help in the prevention of cardiometabolic disorders related to excess EAT.

背景和目的：心外膜脂肪与内脏脂肪组织（VAT）呈正相关。很少有研究探讨心肺功能（CRF）与心外膜脂肪之间的关系。此外，这种关系是否与内脏脂肪组织无关仍未得到探讨。我们的目的是研究 VAT 在无症状女性和男性的心肺功能、体力活动（PA）和心外膜脂肪组织（EAT）之间关系中的作用：我们研究了 239 名表面健康的成年人（43% 为女性）的 EAT 与通过磁共振成像测量的 VAT、通过心肺运动测试测量的 CRF 以及通过计步器和 3 天 PA 日志评估的 PA 之间的关系。根据 EAT tertiles 和 CRF 水平对男女参与者进行了比较。EAT水平最高的参与者有更多的脂肪增值（p 结论：EAT水平最高的参与者有更多的脂肪增值，而EAT水平最低的参与者有更多的脂肪增值：在女性和男性中，增值脂肪似乎是血液循环负荷与进食量之间关系的主要中介，这表明通过改善血液循环负荷来控制增值脂肪有助于预防与进食量过多有关的心脏代谢疾病。

{"title":"Visceral adiposity: A major mediator of the relationship between epicardial adiposity and cardiorespiratory fitness in adults.","authors":"Dominic J Chartrand, Eric Larose, Paul Poirier, Patrick Mathieu, Natalie Alméras, Philippe Pibarot, Benoît Lamarche, Caroline Rhéaume, Isabelle Lemieux, Jean-Pierre Després, Marie-Eve Piché","doi":"10.1016/j.numecd.2024.09.010","DOIUrl":"https://doi.org/10.1016/j.numecd.2024.09.010","url":null,"abstract":"<p><strong>Background and aims: </strong>Epicardial adiposity has been positively associated with visceral adipose tissue (VAT). Few studies have examined the association between cardiorespiratory fitness (CRF) and epicardial adiposity. Furthermore, whether this relationship was independent of VAT remains unexplored. Our purpose was to investigate the contribution of VAT in the relationships between CRF, physical activity (PA) and epicardial adipose tissue (EAT) in asymptomatic women and men.</p><p><strong>Methods and results: </strong>We examined the associations between EAT and VAT measured by magnetic resonance imaging, CRF measured by cardiopulmonary exercise testing, and PA assessed using pedometers and a 3-day PA journal in 239 apparently healthy adults (43 % women). Participants were compared according to EAT tertiles and CRF level in both sexes. Participants with the highest EAT level presented more VAT (p < 0.001), lower CRF (p < 0.01), and a more deteriorated cardiometabolic health score (p < 0.01) than those with the lowest EAT level. CRF was negatively associated with EAT in both sexes (p < 0.01). No significant relationship was found with PA (p = NS). Stepwise multivariable regression analyses showed that VAT explained most of the variance in EAT in women and men. Mediation analyses confirmed that VAT was a mediator of the association between CRF and EAT in both sexes.</p><p><strong>Conclusion: </strong>In women and men, VAT appears as a major mediator of the association between CRF and EAT thereby suggesting that managing VAT by improving CRF could help in the prevention of cardiometabolic disorders related to excess EAT.</p>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142511697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Population dietary-metabolic characteristics and mortality from major cardiovascular disease subtypes: the Seven Contries Study 60-year follow-up 人口膳食代谢特征与主要心血管疾病亚型的死亡率：七国研究 60 年随访。

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases

Pub Date : 2024-09-19 DOI: 10.1016/j.numecd.2024.09.018

Alessandro Menotti , Paolo Emilio Puddu

Background and aim

During the last few years, the Seven Countries Study of Cardiovascular Diseases (SCS) produced some new analyses dealing with the relationships of a dietary score, the pool of dietary fatty acids and serum cholesterol with major types of cardiovascular disease (CVD) mortality in 10 cohorts of 6 countries made of middle-aged men followed-up for 60 years until extinction. This sparse evidence is condensed here to provide a coherent view.

Methods and results

The Mediterranean Adequacy Index (MAI, a dietary score whose high levels depict the characteristics of the Mediterranean Diet), was highly and significantly associated in an inverse way, at country levels, with the Atherogenicity (ATI) and the Thrombogenicity (THI) indexes that included a series of dietary fatty acids. These indexes were highly and significantly associated in a direct way with country baseline serum cholesterol levels. Countries with high serum cholesterol had largely higher death rates from coronary heart disease (CHD) and lower rates from other heart diseases of uncertain etiology and stroke. The reverse was observed in countries with low serum cholesterol.

Conclusion

The chain of diet, dietary fatty acids and serum cholesterol seems to be responsible in various ways for the different distribution of major CVD mortality subtypes in extincted cohorts.

背景和目的：在过去几年中，七国心血管疾病研究（SCS）进行了一些新的分析，涉及膳食评分、膳食脂肪酸库和血清胆固醇与主要类型心血管疾病（CVD）死亡率之间的关系。本文对这些稀少的证据进行了浓缩，以提供一个连贯的观点：地中海充足指数（MAI，一种膳食评分，其高水平反映了地中海饮食的特点）与动脉粥样硬化指数（ATI）和血栓形成指数（THI）（包括一系列膳食脂肪酸）在国家层面上呈显著的反比关系。这些指数与各国的血清胆固醇基线水平有很大的直接关系。高血清胆固醇国家的冠心病死亡率较高，而其他病因不明的心脏病和中风的死亡率较低。血清胆固醇水平低的国家则相反：结论：膳食、膳食脂肪酸和血清胆固醇链似乎在不同方面造成了灭绝队列中主要心血管疾病死亡亚型的不同分布。

{"title":"Population dietary-metabolic characteristics and mortality from major cardiovascular disease subtypes: the Seven Contries Study 60-year follow-up","authors":"Alessandro Menotti , Paolo Emilio Puddu","doi":"10.1016/j.numecd.2024.09.018","DOIUrl":"10.1016/j.numecd.2024.09.018","url":null,"abstract":"<div><h3>Background and aim</h3><div>During the last few years, the Seven Countries Study of Cardiovascular Diseases (SCS) produced some new analyses dealing with the relationships of a dietary score, the pool of dietary fatty acids and serum cholesterol with major types of cardiovascular disease (CVD) mortality in 10 cohorts of 6 countries made of middle-aged men followed-up for 60 years until extinction. This sparse evidence is condensed here to provide a coherent view.</div></div><div><h3>Methods and results</h3><div>The Mediterranean Adequacy Index (MAI, a dietary score whose high levels depict the characteristics of the Mediterranean Diet), was highly and significantly associated in an inverse way, at country levels, with the Atherogenicity (ATI) and the Thrombogenicity (THI) indexes that included a series of dietary fatty acids. These indexes were highly and significantly associated in a direct way with country baseline serum cholesterol levels. Countries with high serum cholesterol had largely higher death rates from coronary heart disease (CHD) and lower rates from other heart diseases of uncertain etiology and stroke. The reverse was observed in countries with low serum cholesterol.</div></div><div><h3>Conclusion</h3><div>The chain of diet, dietary fatty acids and serum cholesterol seems to be responsible in various ways for the different distribution of major CVD mortality subtypes in extincted cohorts.</div></div>","PeriodicalId":49722,"journal":{"name":"Nutrition Metabolism and Cardiovascular Diseases","volume":"34 12","pages":"Pages 2669-2672"},"PeriodicalIF":3.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0