Pub Date : 2024-03-08DOI: 10.1038/s44286-024-00044-2
Mo Qiao
{"title":"Piloting formic acid production from hydrogenated CO2","authors":"Mo Qiao","doi":"10.1038/s44286-024-00044-2","DOIUrl":"10.1038/s44286-024-00044-2","url":null,"abstract":"","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140063874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-08DOI: 10.1038/s44286-024-00042-4
Thomas Dursch
Researchers Katrina Knauer, Taylor Uekert and Alberta Carpenter, each at different stages of their careers, share perspectives on the national laboratory research ecosystem and how it can inspire transformative work in plastics recycling, sustainable manufacturing and beyond.
{"title":"Sustainability research at a national laboratory","authors":"Thomas Dursch","doi":"10.1038/s44286-024-00042-4","DOIUrl":"10.1038/s44286-024-00042-4","url":null,"abstract":"Researchers Katrina Knauer, Taylor Uekert and Alberta Carpenter, each at different stages of their careers, share perspectives on the national laboratory research ecosystem and how it can inspire transformative work in plastics recycling, sustainable manufacturing and beyond.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140063879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-08DOI: 10.1038/s44286-024-00037-1
Pall Thordarson
Conventional linearly responsive methods for quantifying host–guest complexation in supramolecular chemistry have a fairly narrow dynamic range. Now, a logarithmically responsive electrochemical method promises to facilitate the measurement of complex equilibria over a larger dynamic range in host–guest systems.
{"title":"Supercharged supramolecular binding constants","authors":"Pall Thordarson","doi":"10.1038/s44286-024-00037-1","DOIUrl":"10.1038/s44286-024-00037-1","url":null,"abstract":"Conventional linearly responsive methods for quantifying host–guest complexation in supramolecular chemistry have a fairly narrow dynamic range. Now, a logarithmically responsive electrochemical method promises to facilitate the measurement of complex equilibria over a larger dynamic range in host–guest systems.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140063885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Think feedstocks first","authors":"Katarina Babić","doi":"10.1038/s44286-024-00040-6","DOIUrl":"10.1038/s44286-024-00040-6","url":null,"abstract":"Katarina Babić reflects on the need to account for variability in plastic waste feedstocks when designing plastic upcycling and recycling processes.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140063890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-06DOI: 10.1038/s44286-024-00043-3
A self-driving lab, called Fast-Cat, is developed for the rapid, autonomous Pareto-front mapping of homogeneous catalysts in high-pressure, high-temperature gas–liquid reactions. The efficacy of Fast-Cat was demonstrated in performing Pareto-front mappings of phosphorus-based ligands for the hydroformylation of olefins.
{"title":"A self-driving lab for accelerated catalyst development","authors":"","doi":"10.1038/s44286-024-00043-3","DOIUrl":"10.1038/s44286-024-00043-3","url":null,"abstract":"A self-driving lab, called Fast-Cat, is developed for the rapid, autonomous Pareto-front mapping of homogeneous catalysts in high-pressure, high-temperature gas–liquid reactions. The efficacy of Fast-Cat was demonstrated in performing Pareto-front mappings of phosphorus-based ligands for the hydroformylation of olefins.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140063881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-06DOI: 10.1038/s44286-024-00039-z
Shuo Jin, Shifeng Hong, Lynden A. Archer
We explore the challenges and opportunities for electrochemical energy storage technologies that harvest active materials from their surroundings. Progress hinges on advances in chemical engineering science related to membrane design; control of mass transport, reaction kinetics and precipitation at electrified interfaces; and regulation of electrocrystallization of metals through substrate design.
{"title":"Self-sufficient metal–air batteries for autonomous systems","authors":"Shuo Jin, Shifeng Hong, Lynden A. Archer","doi":"10.1038/s44286-024-00039-z","DOIUrl":"10.1038/s44286-024-00039-z","url":null,"abstract":"We explore the challenges and opportunities for electrochemical energy storage technologies that harvest active materials from their surroundings. Progress hinges on advances in chemical engineering science related to membrane design; control of mass transport, reaction kinetics and precipitation at electrified interfaces; and regulation of electrocrystallization of metals through substrate design.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00039-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140063887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-05DOI: 10.1038/s44286-024-00032-6
Hannah E. Holmes, Matthew J. Realff, Ryan P. Lively
Water plays a pivotal role in direct air capture technologies, impacting materials, regeneration processes and product streams. CO2 removal methods, including absorption, adsorption and electrochemical techniques, encounter challenges associated with water, thus reducing their efficacy. Water fluxes into and out of aqueous solvents affect the concentration and overall capture performance. Solid adsorbents co-adsorb water in greater quantities than CO2 and will require effective strategies to address the substantial energy penalty associated with water desorption each cycle. Water-management strategies are imperative for economic viability and minimizing the environmental impact, but the high energy intensity necessitates heat recovery techniques. Feed dehydration can be combined with strategic heat integration of process streams and standard recovery techniques for front-end water management. For back-end approaches, mechanical vapor compression is a viable solution for coupling heat integration with water management, and we highlight potential heat recovery benefits of three implementation methods. Further research into variable climate conditions and water quality impacts is essential for the success of direct air capture technologies. Water management is crucial for enhancing economic viability and minimizing the environmental impact of direct air capture (DAC) technologies, but the high energy intensity necessitates heat recovery techniques. This Perspective discusses several front-end and back-end strategies for coupling water management with heat integration in DAC processes.
{"title":"Water management and heat integration in direct air capture systems","authors":"Hannah E. Holmes, Matthew J. Realff, Ryan P. Lively","doi":"10.1038/s44286-024-00032-6","DOIUrl":"10.1038/s44286-024-00032-6","url":null,"abstract":"Water plays a pivotal role in direct air capture technologies, impacting materials, regeneration processes and product streams. CO2 removal methods, including absorption, adsorption and electrochemical techniques, encounter challenges associated with water, thus reducing their efficacy. Water fluxes into and out of aqueous solvents affect the concentration and overall capture performance. Solid adsorbents co-adsorb water in greater quantities than CO2 and will require effective strategies to address the substantial energy penalty associated with water desorption each cycle. Water-management strategies are imperative for economic viability and minimizing the environmental impact, but the high energy intensity necessitates heat recovery techniques. Feed dehydration can be combined with strategic heat integration of process streams and standard recovery techniques for front-end water management. For back-end approaches, mechanical vapor compression is a viable solution for coupling heat integration with water management, and we highlight potential heat recovery benefits of three implementation methods. Further research into variable climate conditions and water quality impacts is essential for the success of direct air capture technologies. Water management is crucial for enhancing economic viability and minimizing the environmental impact of direct air capture (DAC) technologies, but the high energy intensity necessitates heat recovery techniques. This Perspective discusses several front-end and back-end strategies for coupling water management with heat integration in DAC processes.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00032-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140063868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-04DOI: 10.1038/s44286-024-00036-2
Nika Sokolova, Kristina Haslinger
Fine chemical production mostly relies on petroleum-based chemical synthesis. Now, a process is established to produce benzyl acetate, the main fragrance molecule in jasmine scent, from renewable sugars with engineered bacteria.
{"title":"Jasmine scent from engineered microbes","authors":"Nika Sokolova, Kristina Haslinger","doi":"10.1038/s44286-024-00036-2","DOIUrl":"10.1038/s44286-024-00036-2","url":null,"abstract":"Fine chemical production mostly relies on petroleum-based chemical synthesis. Now, a process is established to produce benzyl acetate, the main fragrance molecule in jasmine scent, from renewable sugars with engineered bacteria.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140063886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-27DOI: 10.1038/s44286-024-00033-5
J. A. Bennett, N. Orouji, M. Khan, S. Sadeghi, J. Rodgers, M. Abolhasani
Ligands play a crucial role in enabling challenging chemical transformations with transition metal-mediated homogeneous catalysts. Despite their undisputed role in homogeneous catalysis, discovery and development of ligands have proven to be a challenging and resource-intensive undertaking. Here, in response, we present a self-driving catalysis laboratory, Fast-Cat, for autonomous and resource-efficient parameter space navigation and Pareto-front mapping of high-temperature, high-pressure, gas–liquid reactions. Fast-Cat enables autonomous ligand benchmarking and multi-objective catalyst performance evaluation with minimal human intervention. Specifically, we utilize Fast-Cat to perform rapid Pareto-front identification of the hydroformylation reaction between syngas (CO and H2) and olefin (1-octene) in the presence of rhodium and various classes of phosphorus-based ligands. By reactor benchmarking, we demonstrate Fast-Cat’s knowledge scalability, essential to fine/specialty chemical industries. We report the details of the modular flow chemistry platform of Fast-Cat and its autonomous experiment-selection strategy for the rapid generation of optimized experimental conditions and in-house data required for supplying machine-learning approaches to reaction and ligand investigations. A self-driving catalysis laboratory, Fast-Cat, is presented for efficient high-throughput screening of high-pressure, high-temperature, gas–liquid reaction conditions using rhodium-catalyzed hydroformylation as a case study. Fast-Cat is used to Pareto map the reaction space and investigate the varying performance of several phosphorus-based hydroformylation ligands.
{"title":"Autonomous reaction Pareto-front mapping with a self-driving catalysis laboratory","authors":"J. A. Bennett, N. Orouji, M. Khan, S. Sadeghi, J. Rodgers, M. Abolhasani","doi":"10.1038/s44286-024-00033-5","DOIUrl":"10.1038/s44286-024-00033-5","url":null,"abstract":"Ligands play a crucial role in enabling challenging chemical transformations with transition metal-mediated homogeneous catalysts. Despite their undisputed role in homogeneous catalysis, discovery and development of ligands have proven to be a challenging and resource-intensive undertaking. Here, in response, we present a self-driving catalysis laboratory, Fast-Cat, for autonomous and resource-efficient parameter space navigation and Pareto-front mapping of high-temperature, high-pressure, gas–liquid reactions. Fast-Cat enables autonomous ligand benchmarking and multi-objective catalyst performance evaluation with minimal human intervention. Specifically, we utilize Fast-Cat to perform rapid Pareto-front identification of the hydroformylation reaction between syngas (CO and H2) and olefin (1-octene) in the presence of rhodium and various classes of phosphorus-based ligands. By reactor benchmarking, we demonstrate Fast-Cat’s knowledge scalability, essential to fine/specialty chemical industries. We report the details of the modular flow chemistry platform of Fast-Cat and its autonomous experiment-selection strategy for the rapid generation of optimized experimental conditions and in-house data required for supplying machine-learning approaches to reaction and ligand investigations. A self-driving catalysis laboratory, Fast-Cat, is presented for efficient high-throughput screening of high-pressure, high-temperature, gas–liquid reaction conditions using rhodium-catalyzed hydroformylation as a case study. Fast-Cat is used to Pareto map the reaction space and investigate the varying performance of several phosphorus-based hydroformylation ligands.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-024-00033-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140063893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23DOI: 10.1038/s44286-023-00022-0
Kyeong Rok Choi, Zi Wei Luo, Gi Bae Kim, Hanwen Xu, Sang Yup Lee
Benzyl acetate is a valuable aromatic ester compound with diverse applications in the flavor and fragrance industries. However, its current synthesis primarily relies on inefficient plant extraction methods or chemical/enzymatic processes that depend on non-renewable substrates. Here we report a sustainable approach to benzyl acetate production from d-glucose using metabolically engineered Escherichia coli strains. We explored both benzoic acid-dependent and -independent synthetic pathways by either dividing the pathway between upstream and downstream strain pairs or by introducing the complete pathway into single, integrated strains. In an optimized two-phase extractive fermentation process, a delayed co-culture of an upstream strain that converts d-glucose to benzoic acid and a downstream strain that transforms benzoic acid into benzyl acetate yielded 2,238.3 ± 171.9 mg l−1 of benzyl acetate from d-glucose in 108 h (or 2,204.0 ± 192.2 mg l−1 in 96 h). The economic competitiveness of the microbial process for sustainable benzyl acetate production was also assessed by techno-economic analysis. Benzyl acetate is a valuable aromatic ester compound used in flavorings and fragrances. Now, a microbial approach is developed to produce benzyl acetate from d-glucose using metabolically engineered Escherichia coli strains and exploiting delayed co-culture strategies.
{"title":"A microbial process for the production of benzyl acetate","authors":"Kyeong Rok Choi, Zi Wei Luo, Gi Bae Kim, Hanwen Xu, Sang Yup Lee","doi":"10.1038/s44286-023-00022-0","DOIUrl":"10.1038/s44286-023-00022-0","url":null,"abstract":"Benzyl acetate is a valuable aromatic ester compound with diverse applications in the flavor and fragrance industries. However, its current synthesis primarily relies on inefficient plant extraction methods or chemical/enzymatic processes that depend on non-renewable substrates. Here we report a sustainable approach to benzyl acetate production from d-glucose using metabolically engineered Escherichia coli strains. We explored both benzoic acid-dependent and -independent synthetic pathways by either dividing the pathway between upstream and downstream strain pairs or by introducing the complete pathway into single, integrated strains. In an optimized two-phase extractive fermentation process, a delayed co-culture of an upstream strain that converts d-glucose to benzoic acid and a downstream strain that transforms benzoic acid into benzyl acetate yielded 2,238.3 ± 171.9 mg l−1 of benzyl acetate from d-glucose in 108 h (or 2,204.0 ± 192.2 mg l−1 in 96 h). The economic competitiveness of the microbial process for sustainable benzyl acetate production was also assessed by techno-economic analysis. Benzyl acetate is a valuable aromatic ester compound used in flavorings and fragrances. Now, a microbial approach is developed to produce benzyl acetate from d-glucose using metabolically engineered Escherichia coli strains and exploiting delayed co-culture strategies.","PeriodicalId":501699,"journal":{"name":"Nature Chemical Engineering","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44286-023-00022-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140063875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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