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Hearing Vocalizations during First Social Experience with Pups Increase Bdnf Transcription in Mouse Auditory Cortex. 幼崽第一次社交经历中听到的声音增加了小鼠听觉皮层的Bdnf转录。
IF 3.1 4区 医学 Q2 NEUROSCIENCES Pub Date : 2023-01-01 DOI: 10.1155/2023/5225952
Amielle Moreno, Swetha Rajagopalan, Matthew J Tucker, Parker Lunsford, Robert C Liu

While infant cues are often assumed to innately motivate maternal response, recent research highlights how the neural coding of infant cues is altered through maternal care. Infant vocalizations are important social signals for caregivers, and evidence from mice suggests that experience caring for mouse pups induces inhibitory plasticity in the auditory cortex (AC), though the molecular mediators for such AC plasticity during the initial pup experience are not well delineated. Here, we used the maternal mouse communication model to explore whether transcription in AC of a specific, inhibition-linked, memory-associated gene, brain-derived neurotrophic factor (Bdnf) changes due to the very first pup caring experience hearing vocalizations, while controlling for the systemic influence of the hormone estrogen. Ovariectomized and estradiol or blank-implanted virgin female mice hearing pup calls with pups present had significantly higher AC exon IV Bdnf mRNA compared to females without pups present, suggesting that the social context of vocalizations induces immediate molecular changes at the site of auditory cortical processing. E2 influenced the rate of maternal behavior but did not significantly affect Bdnf mRNA transcription in the AC. To our knowledge, this is the first time Bdnf has been associated with processing social vocalizations in the AC, and our results suggest that it is a potential molecular component responsible for enhancing future recognition of infant cues by contributing to AC plasticity.

虽然婴儿线索通常被认为是天生激发母亲的反应,但最近的研究强调了婴儿线索的神经编码是如何通过母亲的照顾而改变的。婴儿发声是照顾者重要的社会信号,来自小鼠的证据表明,照顾幼鼠的经历会诱发听觉皮层(AC)的抑制性可塑性,尽管在幼鼠最初经历中这种AC可塑性的分子介质尚未得到很好的描述。在这里,我们使用母鼠通信模型来探索在控制激素雌激素的全身影响的同时,在第一次幼鼠护理经历中,一种特定的,抑制相关的,记忆相关的基因,脑源性神经营养因子(Bdnf)的AC转录是否会因听到叫声而发生变化。卵巢切除、雌二醇或空白植入的雌性雌性小鼠在听到幼崽叫声时,其AC外显子IV Bdnf mRNA显著高于没有幼崽的雌性小鼠,这表明发声的社会背景在听觉皮层加工部位引起了即时的分子变化。E2影响了母性行为的比率,但没有显著影响AC中Bdnf mRNA的转录。据我们所知,这是Bdnf第一次与AC中社会发声的加工有关,我们的结果表明,它是一个潜在的分子成分,负责通过促进AC可塑性来增强未来对婴儿线索的识别。
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引用次数: 0
Retracted: Three Mediating Pathways of Anxiety and Security in the Relationship between Coping Style and Disordered Eating Behaviors among Chinese Female College Students. 中国女大学生应对方式与饮食失调行为关系中焦虑和安全的三条中介途径
IF 3.1 4区 医学 Q2 NEUROSCIENCES Pub Date : 2023-01-01 DOI: 10.1155/2023/9857506
Neural Plasticity

[This retracts the article DOI: 10.1155/2021/7506754.].

[本文撤回文章DOI: 10.1155/2021/7506754]。
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引用次数: 0
The Effect of Swallowing Action Observation Therapy on Resting fMRI in Stroke Patients with Dysphagia. 吞咽动作观察疗法对脑卒中伴吞咽困难患者静息fMRI的影响。
IF 3.1 4区 医学 Q2 NEUROSCIENCES Pub Date : 2023-01-01 DOI: 10.1155/2023/2382980
Ming Zeng, Zhongli Wang, Xuting Chen, Meifang Shi, Meihong Zhu, Jingmei Ma, Yunhai Yao, Yao Cui, Hua Wu, Jie Shen, Lingfu Xie, Jianming Fu, Xudong Gu

Objective: Many stroke victims have severe swallowing problems. Previous neuroimaging studies have found that several brain regions scattered in the frontal, temporal, and parietal lobes, such as Brodmann's areas (BA) 6, 21, and 40, are associated with swallowing function. This study sought to investigate changes in swallowing function and resting-state functional magnetic resonance imaging (rs-fMRI) in stroke patients with dysphagia following action observation treatment. It also sought to detect changes in brain regions associated with swallowing in stroke patients.

Methods: In this study, 12 healthy controls (HCs) and 12 stroke patients were recruited. Stroke patients were given 4 weeks of action observation therapy. In order to assess the differences in mfALFF values between patients before treatment and HCs, the fractional amplitude of low-frequency fluctuations (fALFF) in three frequency bands (conventional frequency band, slow-4, and slow-5) were calculated for fMRI data. The significant brain regions were selected as regions of interest (ROIs) for subsequent analysis. The mfALFF values were extracted from ROIs of the three groups (patients before and after treatment and HCs) and compared to assess the therapeutic efficacy.

Results: In the conventional band, stroke patients before treatment had higher mfALFF in the inferior temporal gyrus and lower mfALFF in the calcarine fissure and surrounding cortex and thalamus compared to HCs. In the slow-4 band, there was no significant difference in related brain regions between stroke patients before treatment and HCs. In the slow-5 band, stroke patients before treatment had higher mfALFF in inferior cerebellum, inferior temporal gyrus, middle frontal gyrus, and lower mfALFF in calcarine fissure and surrounding cortex compared to HCs. We also assessed changes in aberrant brain activity that occurred both before and after action observation therapy. The mfALFF between stroke patients after therapy was closed to HCs in comparison to the patients before treatment.

Conclusion: Action observation therapy can affect the excitability of certain brain regions. The changes in brain function brought about by this treatment may help to further understand the potential mechanism of network remodeling of swallowing function.

目的:许多中风患者有严重的吞咽问题。先前的神经影像学研究发现,分散在额叶、颞叶和顶叶的几个大脑区域,如Brodmann区(BA) 6、21和40,与吞咽功能有关。本研究旨在探讨脑卒中吞咽困难患者在动作观察治疗后吞咽功能和静息状态功能磁共振成像(rs-fMRI)的变化。它还试图检测中风患者与吞咽相关的大脑区域的变化。方法:选取12例健康对照(hc)和12例脑卒中患者作为研究对象。脑卒中患者给予4周的动作观察治疗。为了评估治疗前患者与hcc之间mfALFF值的差异,对fMRI数据计算三个频带(常规频带、慢-4和慢-5)的低频波动分数幅值(fALFF)。选取显著脑区作为感兴趣区(roi)进行后续分析。从三组(患者治疗前后和hc)的roi中提取mfALFF值,比较其治疗效果。结果:在常规波段,与hc相比,治疗前脑卒中患者颞下回mfALFF较高,胼胝体裂及周围皮层和丘脑mfALFF较低。在慢-4波段,治疗前脑卒中患者与hcc患者相关脑区无显著差异。在慢-5波段,治疗前脑卒中患者小脑下端、颞下回、额中回的mfALFF较hc高,脑钙裂及周围皮层的mfALFF较hc低。我们还评估了在行动观察治疗前后发生的异常脑活动的变化。与治疗前相比,治疗后卒中患者之间的mfALFF与hcc接近。结论:动作观察疗法可影响大脑某些区域的兴奋性。这种治疗所带来的脑功能改变可能有助于进一步了解吞咽功能网络重塑的潜在机制。
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引用次数: 1
Electroencephalogram-Based Brain Connectivity Analysis in Prolonged Disorders of Consciousness. 基于脑电图的长时间意识障碍脑连通性分析。
IF 3.1 4区 医学 Q2 NEUROSCIENCES Pub Date : 2023-01-01 DOI: 10.1155/2023/4142053
Yuzhang Wu, Zhitao Li, Ruowei Qu, Yangang Wang, Zhongzhen Li, Le Wang, Guangrui Zhao, Keke Feng, Yifeng Cheng, Shaoya Yin

Background: Prolonged disorders of consciousness (pDOC) are common in neurology and place a heavy burden on families and society. This study is aimed at investigating the characteristics of brain connectivity in patients with pDOC based on quantitative EEG (qEEG) and extending a new direction for the evaluation of pDOC.

Methods: Participants were divided into a control group (CG) and a DOC group by the presence or absence of pDOC. Participants underwent magnetic resonance imaging (MRI) T1 three-dimensional magnetization with a prepared rapid acquisition gradient echo (3D-T1-MPRAGE) sequence, and video EEG data were collected. After calculating the power spectrum by EEG data analysis tool, DTABR ((δ + θ)/(α + β) ratio), Pearson's correlation coefficient (Pearson r), Granger's causality, and phase transfer entropy (PTE), we performed statistical analysis between two groups. Finally, receiver operating characteristic (ROC) curves of connectivity metrics were made.

Results: The proportion of power in frontal, central, parietal, and temporal regions in the DOC group was lower than that in the CG. The percentage of delta power in the DOC group was significantly higher than that in the CG, the DTABR in the DOC group was higher than that in the CG, and the value was inverted. The Pearson r of the DOC group was higher than that of CG. The Pearson r of the delta band (Z = -6.71, P < 0.01), theta band (Z = -15.06, P < 0.01), and alpha band (Z = -28.45, P < 0.01) were statistically significant. Granger causality showed that the intensity of directed connections between the two hemispheres in the DOC group at the same threshold was significantly reduced (Z = -82.43, P < 0.01). The PTE of each frequency band in the DOC group was lower than that in the CG. The PTE of the delta band (Z = -42.68, P < 0.01), theta band (Z = -56.79, P < 0.01), the alpha band (Z = -35.11, P < 0.01), and beta band (Z = -63.74, P < 0.01) had statistical significance.

Conclusion: Brain connectivity analysis based on EEG has the advantages of being noninvasive, convenient, and bedside. The Pearson r of DTABR, delta, theta, and alpha bands, Granger's causality, and PTE of the delta, theta, alpha, and beta bands can be used as biological markers to distinguish between pDOC and healthy people, especially when behavior evaluation is difficult or ambiguous; it can supplement clinical diagnosis.

背景:延长性意识障碍(pDOC)在神经病学中很常见,给家庭和社会带来了沉重的负担。本研究旨在探讨基于定量脑电图(qEEG)的pDOC患者脑连通性特征,为pDOC的评价拓展新的方向。方法:根据有无pDOC分为对照组(CG)和DOC组。参与者接受磁共振成像(MRI) T1三维磁化,并采用准备好的快速采集梯度回波(3D-T1-MPRAGE)序列,并收集视频脑电数据。通过脑电数据分析工具计算功率谱、DTABR ((δ + θ)/(α + β)比、Pearson相关系数(Pearson r)、Granger因果关系、相转移熵(PTE),对两组进行统计学分析。最后,绘制连通性指标的受试者工作特征(ROC)曲线。结果:DOC组在额、中央、顶叶和颞叶区域的权力比例低于CG组。DOC组的δ功率百分比显著高于CG组,DOC组的DTABR高于CG组,且数值呈倒转。DOC组的Pearson r高于CG组。δ波段(Z = -6.71, P < 0.01)、θ波段(Z = -15.06, P < 0.01)、α波段(Z = -28.45, P < 0.01)的Pearson r均有统计学意义。格兰杰因果关系显示,在相同阈值下,DOC组两半球间定向连接强度显著降低(Z = -82.43, P < 0.01)。DOC组各频段PTE均低于CG组。δ波段(Z = -42.68, P < 0.01)、θ波段(Z = -56.79, P < 0.01)、α波段(Z = -35.11, P < 0.01)、β波段(Z = -63.74, P < 0.01)的PTE差异均有统计学意义。结论:基于脑电图的脑连通性分析具有无创、方便、床边等优点。DTABR、delta、theta和alpha波段的Pearson r、Granger因果关系和delta、theta、alpha和beta波段的PTE可以作为区分pDOC和健康人的生物标记,特别是在行为评价困难或模糊的情况下;它可以补充临床诊断。
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引用次数: 1
Olfactory Loss and Brain Connectivity after COVID-19: Structural Follow-Up at One Year. 2019冠状病毒病后嗅觉丧失和大脑连通性:一年的结构随访。
IF 3.1 4区 医学 Q2 NEUROSCIENCES Pub Date : 2023-01-01 DOI: 10.1155/2023/6496539
Fabrizio Esposito, Mario Cirillo, Rosa De Micco, Giuseppina Caiazzo, Mattia Siciliano, Andrea G Russo, Caterina Monari, Nicola Coppola, Gioacchino Tedeschi, Alessandro Tessitore

The structural connectivity from the primary olfactory cortex to the main secondary olfactory areas was previously reported as relatively increased in the medial orbitofrontal cortex in a cohort of 27 recently SARS-CoV-2-infected (COV+) subjects, of which 23/27 had clinically confirmed olfactory loss, compared to 18 control (COV-) normosmic subjects, who were not previously infected. To complement this finding, here we report the outcome of an identical high angular resolution diffusion MRI analysis on follow-up data sets collected in 18/27 COV+ subjects (10 males, mean age ± SD: 38.7 ± 8.1 years) and 10/18 COV- subjects (5 males, mean age ± SD: 33.1 ± 3.6 years) from the previous samples who repeated both the olfactory functional assessment and the MRI examination after ~1 year. By comparing the newly derived subgroups, we observed that the increase in the structural connectivity index of the medial orbitofrontal cortex was not significant at follow-up, despite 10/18 COV+ subjects were still found hyposmic after ~1 year from SARS-CoV-2 infection. We concluded that the relative hyperconnectivity of the olfactory cortex to the medial orbitofrontal cortex could be, at least in some cases, an acute or reversible phenomenon linked to the recent SARS-CoV-2 infection with associated olfactory loss.

先前有报道称,在27名最近感染sars - COV- 2 (COV+)的受试者中,初级嗅觉皮层与主要次级嗅觉区域的结构连通性在内侧眶额皮质中相对增加,其中23/27临床证实嗅觉丧失,而对照组(COV-)正常的受试者中有18名以前未感染。为了补充这一发现,本文报告了对18/27名COV+受试者(10名男性,平均年龄±SD: 38.7±8.1岁)和10/18名COV-受试者(5名男性,平均年龄±SD: 33.1±3.6岁)收集的随访数据集进行相同的高角分辨率扩散MRI分析的结果,这些受试者在1年后重复了嗅觉功能评估和MRI检查。通过比较新衍生的亚组,我们观察到,尽管10/18 COV+受试者在感染SARS-CoV-2约1年后仍发现低呼吸,但随访时内侧眶额叶皮层结构连通性指数的增加并不显著。我们得出的结论是,至少在某些情况下,嗅觉皮层与内侧眶额皮质的相对超连通性可能是一种急性或可逆的现象,与最近的SARS-CoV-2感染相关的嗅觉丧失有关。
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引用次数: 22
Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy. 成人癫痫患者认知功能与睡眠纺锤体特征的评估。
IF 3.1 4区 医学 Q2 NEUROSCIENCES Pub Date : 2023-01-01 DOI: 10.1155/2023/7768980
Yajin Huang, Yaqing Liu, Wenjun Song, Yanjun Liu, Xiaoqian Wang, Juping Han, Jiang Ye, Hongmei Han, Li Wang, Juan Li, Tiancheng Wang

Objective: Epilepsy may cause chronic cognitive impairment by disturbing sleep plasticity. Sleep spindles play a crucial role in sleep maintenance and brain plasticity. This study explored the relationship between cognition and spindle characteristics in adult epilepsy.

Methods: Participants underwent one-night sleep electroencephalogram recording and neuropsychological tests on the same day. Spindle characteristics during N2 sleep were extracted using a learning-based system for sleep staging and an automated spindle detection algorithm. We investigated the difference between cognitive subgroups in spindle characteristics. Multiple linear regressions were applied to analyze associations between cognition and spindle characteristics.

Results: Compared with no/mild cognitive impairment, epilepsy patients who developed severe cognitive impairment had lower sleep spindle density, the differences mainly distributed in central, occipital, parietal, middle temporal, and posterior temporal (P < 0.05), and had relatively long spindle duration in occipital and posterior temporal (P < 0.05). Mini-Mental State Examination (MMSE) was associated with spindle density (pars triangularis of the inferior frontal gyrus (IFGtri): β = 0.253, P = 0.015, and P.adjust = 0.074) and spindle duration (IFGtri: β = -0.262, P = 0.004, and P.adjust = 0.030). Montreal Cognitive Assessment (MoCA) was associated with spindle duration (IFGtri: β = -0.246, P = 0.010, and P.adjust = 0.055). Executive Index Score (MoCA-EIS) was associated with spindle density (IFGtri: β = 0.238, P = 0.019, and P.adjust = 0.087; parietal: β = 0.227, P = 0.017, and P.adjust = 0.082) and spindle duration (parietal: β = -0.230, P = 0.013, and P.adjust = 0.065). Attention Index Score (MoCA-AIS) was associated with spindle duration (IFGtri: β = -0.233, P = 0.017, and P.adjust = 0.081).

Conclusions: The findings suggested that the altered spindle activity in epilepsy with severe cognitive impairment, the associations between the global cognitive status of adult epilepsy and spindle characteristics, and specific cognitive domains may relate to spindle characteristics in particular brain regions.

目的:癫痫可通过干扰睡眠可塑性导致慢性认知功能障碍。睡眠纺锤波在睡眠维持和大脑可塑性中起着至关重要的作用。本研究探讨成人癫痫患者认知与纺锤体特征的关系。方法:对受试者进行夜间睡眠脑电图记录,并于当天进行神经心理测试。采用基于学习的睡眠分期系统和自动纺锤波检测算法提取N2睡眠时的纺锤波特征。我们研究了认知亚组在纺锤体特征上的差异。采用多元线性回归分析认知与纺锤体特征之间的关系。结果:与无/轻度认知障碍的癫痫患者相比,重度认知障碍的癫痫患者睡眠纺锤体密度较低,差异主要分布在中央、枕部、顶叶、颞中部和颞后部(P < 0.05),枕部和颞后部纺锤体持续时间较长(P < 0.05)。迷你精神状态检查(MMSE)与纺锤体密度(额下回三角部(IFGtri): β = 0.253, P = 0.015, P.adjust = 0.074)和纺锤体持续时间(IFGtri: β = -0.262, P = 0.004, P.adjust = 0.030)相关。蒙特利尔认知评估(MoCA)与纺锤体持续时间相关(IFGtri: β = -0.246, P = 0.010, P.adjust = 0.055)。执行指数评分(MoCA-EIS)与纺锤体密度相关(IFGtri: β = 0.238, P = 0.019, P.adjust = 0.087;顶叶:β = 0.227, P = 0.017, P.adjust = 0.082)和纺锤体持续时间(顶叶:β = -0.230, P = 0.013, P.adjust = 0.065)。注意指数得分(MoCA-AIS)与纺锤波持续时间相关(IFGtri: β = -0.233, P = 0.017, P.adjust = 0.081)。结论:研究结果表明,严重认知障碍癫痫患者的纺锤体活动改变,成人癫痫的整体认知状态与纺锤体特征之间的关联,以及特定的认知领域可能与特定脑区的纺锤体特征有关。
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引用次数: 1
Fractalkine/CX3CR1-Dependent Modulation of Synaptic and Network Plasticity in Health and Disease. Fractalkine/ cx3cr1依赖性突触和网络可塑性在健康和疾病中的调节。
IF 3.1 4区 医学 Q2 NEUROSCIENCES Pub Date : 2023-01-01 DOI: 10.1155/2023/4637073
N P Camacho-Hernández, F Peña-Ortega

CX3CR1 is a G protein-coupled receptor that is expressed exclusively by microglia within the brain parenchyma. The only known physiological CX3CR1 ligand is the chemokine fractalkine (FKN), which is constitutively expressed in neuronal cell membranes and tonically released by them. Through its key role in microglia-neuron communication, the FKN/CX3CR1 axis regulates microglial state, neuronal survival, synaptic plasticity, and a variety of synaptic functions, as well as neuronal excitability via cytokine release modulation, chemotaxis, and phagocytosis. Thus, the absence of CX3CR1 or any failure in the FKN/CX3CR1 axis has been linked to alterations in different brain functions, including changes in synaptic and network plasticity in structures such as the hippocampus, cortex, brainstem, and spinal cord. Since synaptic plasticity is a basic phenomenon in neural circuit integration and adjustment, here, we will review its modulation by the FKN/CX3CR1 axis in diverse brain circuits and its impact on brain function and adaptation in health and disease.

CX3CR1是一种G蛋白偶联受体,仅在脑实质内的小胶质细胞中表达。唯一已知的生理CX3CR1配体是趋化因子fractalkine (FKN), FKN在神经元细胞膜上组成性表达,并由神经元细胞膜张力释放。FKN/CX3CR1轴通过其在小胶质-神经元通讯中的关键作用,调节小胶质状态、神经元存活、突触可塑性和各种突触功能,以及通过细胞因子释放调节、趋化性和吞噬作用调节神经元的兴奋性。因此,CX3CR1缺失或FKN/CX3CR1轴的任何故障都与不同脑功能的改变有关,包括海马、皮层、脑干和脊髓等结构的突触和网络可塑性的改变。由于突触可塑性是神经回路整合和调节的基本现象,在这里,我们将回顾FKN/CX3CR1轴在不同脑回路中的调节作用及其对健康和疾病中脑功能和适应的影响。
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引用次数: 2
Astragaloside IV Alleviates Brain Injury Induced by Hypoxia via the Calpain-1 Signaling Pathway. 黄芪皂苷 IV 通过钙蛋白酶-1 信号通路缓解缺氧引起的脑损伤
IF 3 4区 医学 Q2 NEUROSCIENCES Pub Date : 2022-12-03 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6509981
Yan Meng, Shengxue Yu, Fang Zhao, Yu Liu, Yue Wang, Siqi Fan, Yuhong Su, Meili Lu, Hongxin Wang

Long-term hypoxia can induce oxidative stress and apoptosis in hippocampal neurons that can lead to brain injury diseases. Astragaloside IV (AS-IV) is widely used in the antiapoptotic therapy of brain injury diseases. However, its mechanism of action is still not fully understood. In this study, we investigated the effect of AS-IV on hypoxia-induced oxidative stress and apoptosis in hippocampal neurons and explored its possible mechanism. In vivo, mice were placed in a hypoxic circulatory device containing 10% O2 and gavaged with AS-IV (60 and 120 mg/kg/d) for 4 weeks. In vitro, mouse hippocampal neuronal cells (HT22) were treated with hypoxia (1% O2) for 24 hours in the presence or absence of AS-IV, MDL-28170 (calpain-1 inhibitor), or YC-1 (HIF-1α inhibitor). The protective effect of AS-IV on brain injury was further explored by examining calpain-1 knockout mice. The results showed that hypoxia induced damage to hippocampal neurons, impaired spatial learning and memory abilities, and increased oxidative stress and apoptosis. Treatment with AS-IV or calpain-1 knockout improved the damage to hippocampal neurons and spatial learning and memory, attenuated oxidative stress and inhibited cell apoptosis. These changes were verified in HT22 cells. Overexpression of calpain-1 abolished the improvement of AS-IV on apoptosis and oxidative stress. In addition, the effects of AS-IV were accompanied by decreased calpain-1 and HIF-1α expression, and YC-1 showed a similar effect as AS-IV on calpain-1 and caspase-3 expression. In conclusion, this study demonstrates that AS-IV can downregulate the calpain-1/HIF-1α/caspase-3 pathway and inhibit oxidative stress and apoptosis of hippocampal neurons induced by hypoxia, which provides new ideas for studying the antiapoptotic activity of AS-IV.

长期缺氧可诱导海马神经元氧化应激和凋亡,从而导致脑损伤疾病。黄芪皂苷 IV(AS-IV)被广泛用于脑损伤疾病的抗凋亡治疗。然而,人们对其作用机制仍不完全了解。在这项研究中,我们研究了 AS-IV 对缺氧诱导的海马神经元氧化应激和凋亡的影响,并探讨了其可能的机制。在体内,将小鼠置于含10%氧气的低氧循环装置中,灌胃AS-IV(60和120 mg/kg/d),连续4周。在体外,小鼠海马神经元细胞(HT22)在AS-IV、MDL-28170(钙蛋白酶-1抑制剂)或YC-1(HIF-1α抑制剂)存在或不存在的情况下,接受缺氧(1% O2)处理24小时。通过研究钙蛋白酶-1基因敲除小鼠,进一步探讨了AS-IV对脑损伤的保护作用。结果表明,缺氧会诱发海马神经元损伤,损害空间学习和记忆能力,并增加氧化应激和细胞凋亡。用AS-IV或钙蛋白酶1基因敲除治疗可改善海马神经元损伤、空间学习和记忆能力,减轻氧化应激,抑制细胞凋亡。这些变化在 HT22 细胞中得到了验证。过量表达钙蛋白酶-1会取消AS-IV对细胞凋亡和氧化应激的改善作用。此外,AS-IV的作用还伴随着钙蛋白酶-1和HIF-1α表达的减少,YC-1对钙蛋白酶-1和caspase-3表达的影响与AS-IV相似。总之,本研究表明,AS-IV能下调钙蛋白酶-1/HIF-1α/caspase-3通路,抑制缺氧诱导的海马神经元氧化应激和凋亡,为研究AS-IV的抗凋亡活性提供了新思路。
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引用次数: 0
Low Intensity Noise Exposure Enhanced Auditory Loudness and Temporal Processing by Increasing Excitability of DCN. 低强度噪声暴露可通过提高直流神经网络的兴奋性来增强听觉响度和时序处理。
IF 3.1 4区 医学 Q2 NEUROSCIENCES Pub Date : 2022-11-21 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6463355
Lin Shi, Katie Palmer, Haolin Wang, Matthew A Xu-Friedman, Wei Sun

Sound stimulation is generally used for tinnitus and hyperacusis treatment. Recent studies found that long-term noise exposure can change synaptic and firing properties in the central auditory system, which will be detected by the acoustic startle reflex. However, the perceptual consequences of long-term low-intensity sound exposure are indistinct. This study will detect the effects of moderate-level noise exposure (83 dB SPL) on auditory loudness, and temporal processing was evaluated using CBA/CaJ mice. C-Fos staining was used to detect neural activity changes in the central auditory pathway. With two weeks of 83 dB SPL noise exposure (8 hours per day), no persistent threshold shift of the auditory brainstem response (ABR) was identified. On the other hand, noise exposure enhanced the acoustic startle response (ASR) and gap-induced prepulse inhibition significantly (gap-PPI). Low-level noise exposure, according to the findings, can alter temporal acuity. Noise exposure increased the number of c-Fos labeled neurons in the dorsal cochlear nucleus (DCN) and caudal pontine reticular nucleus (PnC) but not at a higher level in the central auditory nuclei. Our results suggested that noise stimulation can change acoustical temporal processing presumably by increasing the excitability of auditory brainstem neurons.

声音刺激通常用于治疗耳鸣和听力减退。最近的研究发现,长期暴露于噪声环境中会改变中枢听觉系统的突触和发射特性,这将通过声惊跳反射检测到。然而,长期暴露于低强度的声音所产生的感知后果尚不明确。本研究将检测中等强度的噪音暴露(83 dB SPL)对听觉响度的影响,并使用 CBA/CaJ 小鼠对时间处理进行评估。C-Fos 染色用于检测中央听觉通路的神经活动变化。在暴露于 83 dB SPL 噪声(每天 8 小时)两周后,没有发现听性脑干反应(ABR)的持续阈值移动。另一方面,暴露于噪声环境会显著增强声学惊吓反应(ASR)和间隙诱导的前脉冲抑制(gap-PPI)。研究结果表明,低水平的噪音暴露会改变颞叶的敏锐度。噪声暴露会增加耳蜗背核(DCN)和尾部桥脑网状核(PnC)中的c-Fos标记神经元数量,但听觉中枢神经核中的c-Fos标记神经元数量不会增加。我们的研究结果表明,噪声刺激可能通过提高听觉脑干神经元的兴奋性来改变声音的时间处理。
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引用次数: 0
Altered Effective Connectivity of the Primary Motor Cortex in Transient Ischemic Attack. 短暂性脑缺血发作时初级运动皮层有效连接性的改变
IF 3 4区 医学 Q2 NEUROSCIENCES Pub Date : 2022-11-18 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2219993
Zeqi Hao, Yulin Song, Yuyu Shi, Hongyu Xi, Hongqiang Zhang, Mengqi Zhao, Jiahao Yu, Lina Huang, Huayun Li

Objective: This study is aimed at exploring alteration in motor-related effective connectivity in individuals with transient ischemic attack (TIA).

Methods: A total of 48 individuals with TIA and 41 age-matched and sex-matched healthy controls (HCs) were recruited for this study. The participants were scanned using MRI, and their clinical characteristics were collected. To investigate motor-related effective connectivity differences between individuals with TIA and HCs, the bilateral primary motor cortex (M1) was used as the regions of interest (ROIs) to perform a whole-brain Granger causality analysis (GCA). Furthermore, partial correlation was used to evaluate the relationship between GCA values and the clinical characteristics of individuals with TIA.

Results: Compared with HCs, individuals with TIA demonstrated alterations in the effective connectivity between M1 and widely distributed brain regions involved in motor, visual, auditory, and sensory integration. In addition, GCA values were significantly correlated with high- and low-density lipoprotein cholesterols in individuals with TIA.

Conclusion: This study provides important evidence for the alteration of motor-related effective connectivity in TIA, which reflects the abnormal information flow between different brain regions. This could help further elucidate the pathological mechanisms of motor impairment in individuals with TIA and provide a new perspective for future early diagnosis and intervention for TIA.

研究目的本研究旨在探讨短暂性脑缺血发作(TIA)患者运动相关有效连接性的改变:方法:本研究共招募了 48 名 TIA 患者和 41 名年龄和性别匹配的健康对照组(HCs)。方法:本研究共招募了 48 名 TIA 患者和 41 名年龄和性别相匹配的健康对照组(HCs),使用核磁共振成像对参与者进行扫描,并收集他们的临床特征。为了研究 TIA 患者和 HC 之间与运动相关的有效连接差异,研究人员使用双侧初级运动皮层(M1)作为感兴趣区(ROI),进行全脑格兰杰因果关系分析(GCA)。此外,还利用偏相关性评估了GCA值与TIA患者临床特征之间的关系:结果:与普通人相比,TIA 患者的 M1 与广泛分布的脑区之间的有效连接发生了改变,这些脑区涉及运动、视觉、听觉和感觉整合。此外,TIA 患者的 GCA 值与高密度和低密度脂蛋白胆固醇呈显著相关:结论:本研究为 TIA 患者运动相关有效连接的改变提供了重要证据,这反映了不同脑区之间的信息流异常。这有助于进一步阐明 TIA 患者运动障碍的病理机制,并为未来 TIA 的早期诊断和干预提供新的视角。
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引用次数: 0
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