Journal of Affective Disorders Reports最新文献

英文中文

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01

引用次数: 0

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01

引用次数: 0

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01

引用次数: 0

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01

引用次数: 0

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01

引用次数: 0

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2026-01-01

引用次数: 0

A pilot study of brain correlates of long-term treatment with transcutaneous vagal nerve stimulation in posttraumatic stress disorder 经皮迷走神经刺激长期治疗创伤后应激障碍的脑相关性初步研究

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-12-24 DOI: 10.1016/j.jadr.2025.101014

J. Douglas Bremner , Matthew T. Wittbrodt , Nil Z. Gurel , Jonathon A. Nye , Md Mobashir H. Shandhi , Asim H. Gazi , Amit J. Shah , Victoria Amorim , Bradley D. Pearce , Viola Vaccarino , Omer T. Inan

Objective

Posttraumatic Stress Disorder (PTSD) is a highly prevalent condition, and current treatments have limitations. Vagal Nerve Stimulation (VNS) is a new approach that potentially has promise for PTSD. Understanding the neurobiology of treatment response is important for developing new treatments. The purpose of this study was to assess neural correlations of long-term transcutaneous cervical VNS (tcVNS) in patients with PTSD.

Methods

Patients with PTSD underwent randomization to active tcVNS (N = 6) or sham stimulation (N = 5) twice daily for three months. High-Resolution Positron Emission Tomography scanning with radiolabeled water was used to measure brain blood flow measurements before and after treatment during exposure to personalized traumatic scripts paired with active or sham stimulation.

Results

Three months of active tcVNS resulted in activation in response to traumatic scripts in the sham stimulation group not seen in the tcVNS group in brain areas mediating the fear response, including posterior cingulate, thalamus, temporal and parietal cortex, and parahippocampal gyrus, with an increase in medial prefrontal cortex with tcVNS, in patients with PTSD.

Conclusion

TcVNS affects brain areas mediating fear and emotion which may underlie a therapeutic effect for PTSD.

目的创伤后应激障碍（PTSD）是一种非常普遍的疾病，目前的治疗存在局限性。迷走神经刺激（VNS）是一种治疗创伤后应激障碍的新方法。了解治疗反应的神经生物学对开发新的治疗方法很重要。本研究的目的是评估PTSD患者长期经皮颈椎VNS （tcVNS）的神经相关性。方法将PTSD患者随机分为主动tcVNS组（N = 6）和假刺激组（N = 5），每天2次，连续3个月。高分辨率正电子发射断层扫描与放射性标记水被用来测量治疗前后的脑血流量测量暴露于个性化创伤脚本配对的主动或虚假刺激。结果假性刺激3个月后，创伤后应激障碍患者的后扣带回、丘脑、颞叶和顶叶皮层、海马旁回等恐惧反应脑区出现了tcVNS组未见的激活，并增加了内侧前额叶皮层。结论tcvns对创伤后应激障碍（PTSD）的治疗作用可能与调节恐惧和情绪的脑区有关。

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引用次数: 0

Mental health in adults aged 50+ since the COVID-19 pandemic: Are we (all) back to ‘normal’? evidence from England 自COVID-19大流行以来50岁以上成年人的心理健康：我们（所有人）是否恢复了“正常”？来自英格兰的证据

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-12-20 DOI: 10.1016/j.jadr.2025.101012

Darío Moreno-Agostino , Giorgio Di Gessa

Objectives

To understand how population mental health levels and inequalities in these are in the post-lockdown world compared to before the pandemic in adults aged 50 and older.

Methods

We used data from three Waves (2016–2017, n = 7191; 2018–2019, n = 7286; and 2021–2023, n = 6249) of the English Longitudinal Study of Ageing. Using linear and modified Poisson regression models, we investigated whether prevalence of high depressive symptomatology, anxiety, and loneliness, and quality-of-life levels changed across time points overall and by gender, living situation, and wealth quintiles. Models were adjusted for age group, gender, education, and long-standing illnesses.

Results

No significant differences were found between 2016–2017 and 2018–2019. However, compared to 2018–2019, prevalence of high depressive symptoms (RR_2021–2023 = 1.23[95 %CI 1.12;1.34], p < 0.001), loneliness (RR_2021–2023 = 1.32[1.22;1.42], p < 0.001) and quality-of-life levels (B_2021–2023 = -1.84 [-2.21;-1.48], p < 0.001) were worse by 2021–2023. Pre-existing inequalities by gender, living arrangements, and wealth were not significantly different after the pandemic, except for depression, where gaps were significantly smaller by gender (RR_{2021–2023*women} = 0.72[0.59;0.89], p = 0.002) and, to a smaller extent, living situation (RR_{2021–2023*not_alone}=1.22[1.02;1.47], p = 0.026).

Conclusion

Population mental health levels in the population aged 50 and older seem to have declined after the pandemic, and inequalities within the population persist.

目的了解封锁后与大流行前相比，50岁及以上成年人的心理健康水平和不平等情况。方法采用英国老龄化纵向研究的三期（2016-2017年，n = 7191； 2018-2019年，n = 7286； 2021-2023年，n = 6249）数据。使用线性和修正泊松回归模型，我们调查了高抑郁症状、焦虑和孤独的患病率以及生活质量水平是否在整体时间点、性别、生活状况和财富五分位数之间发生变化。模型根据年龄组、性别、教育程度和长期疾病进行了调整。结果2016-2017年与2018-2019年无显著差异。然而，与2018-2019年相比，2021-2023年高抑郁症状（RR2021-2023 = 1.23[95% CI 1.12;1.34], p < 0.001）、孤独感（RR2021-2023 = 1.32[1.22;1.42], p < 0.001）和生活质量水平（B2021-2023 = -1.84 [-2.21;-1.48], p < 0.001）的患病率更差。大流行之后，性别、生活安排和财富方面存在的不平等现象没有显著差异，但抑郁症方面的性别差距明显较小（RR2021-2023 *women = 0.72[0.59;0.89], p = 0.002），生活状况方面的差距较小（RR2021-2023 *not_alone=1.22[1.02;1.47], p = 0.026）。结论大流行后，50岁及以上人群的心理健康水平似乎有所下降，人群内部的不平等现象仍然存在。

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引用次数: 0

The self-reported positive and negative effects of electroconvulsive therapy: an international survey 电休克治疗自我报告的积极和消极影响：一项国际调查

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-12-09 DOI: 10.1016/j.jadr.2025.101008

John Read , Sue Cunliffe , Sarah Hancock , Christopher Harrop , Lucy Johnstone , Lisa Morrison

Background

When assessing the efficacy and safety of any medical procedure the experiences of patients need to be considered. This paper adds to the growing body of studies asking recipients of electroconvulsive therapy about their treatment experiences.

Methods

Open questions about the positive and negative effects of ECT, in an online international survey, were responded to by 776 ECT recipients, from 41 countries.

Results

About half (48.8 %) spontaneously reported one or more positive effects and almost all (96.9 %) spontaneously reported one or more negative effects. About half (51.2 %) reported only negative effects, 45.6 % reported a mixture of positive and negative effects and 3.2 % reported only positive outcomes. Content analysis found that the most reported positive effects were: ‘Improved Mood’ (23.2 %), ‘Reduced Suicidality’ (12.6 %) and ‘Reduced Psychosis’ (3.1 %). The most reported negative effects were: ‘Memory Loss’ (81.6 %), ‘Cognitive Decline’ (29.0 %), ‘Headache’ (11.1 %), ‘Abused/Violated/Traumatised’ (7.9 %), ‘Fear/Anxiety’ (6.8 %), ‘Impaired Relationships’ (5.4 %), ‘Brain Damage’ (5.0 %), ‘Can’t Work’ (4.9 %) and ‘Pain’ (4.9 %).

Limitations

This convenience sample may have been biased towards those with negative or positive attitudes about ECT. Some of the negative and positive effects attributed to ECT may have been the result of other factors (such as illness and age, or placebo, respectively).

Conclusions

These results, in conjunction with previous studies, suggest the need for new, more robust, independent research into safety and efficacy. The safety component of such studies should probably include adverse effects beyond memory loss and cognitive decline.

背景：在评估任何医疗程序的有效性和安全性时，需要考虑患者的经验。这篇论文增加了越来越多的研究，询问电休克治疗的接受者他们的治疗经历。方法在一项在线国际调查中，来自41个国家的776名ECT接受者回答了关于ECT的积极和消极影响的公开问题。结果约一半（48.8%）患者自发报告了一种或多种积极作用，几乎所有（96.9%）患者自发报告了一种或多种消极作用。大约一半（51.2%）报告只有负面影响，45.6%报告积极和消极影响混合，3.2%报告只有积极结果。内容分析发现，报告最多的积极影响是：“改善情绪”（23.2%），“减少自杀”（12.6%）和“减少精神病”（3.1%）。报告最多的负面影响是：“记忆丧失”（81.6%）、“认知能力下降”（29.0%）、“头痛”（11.1%）、“被虐待/被侵犯/受到精神创伤”（7.9%）、“恐惧/焦虑”（6.8%）、“人际关系受损”（5.4%）、“脑损伤”（5.0%）、“无法工作”（4.9%）和“疼痛”（4.9%）。这个便利样本可能偏向于那些对电痉挛疗法持消极或积极态度的人。ECT的一些消极和积极影响可能是其他因素（如疾病和年龄，或安慰剂）的结果。这些结果与先前的研究相结合，表明需要对安全性和有效性进行新的、更有力的、独立的研究。此类研究的安全成分可能包括记忆丧失和认知能力下降以外的不良影响。

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引用次数: 0

Examining the triad of sensory processing, ADHD symptoms, and executive functioning in adults with ADHD: Evidence from a multi-measure assessment 检查成人ADHD患者的感觉加工、ADHD症状和执行功能：来自多测量评估的证据

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-12-09 DOI: 10.1016/j.jadr.2025.101002

Marcel Schulze , Diana Immel , Helena Rosen , Behrem Aslan , Silke Lux , Alexandra Philipsen

Introduction

Executive function (EF) impairments are well-documented in attention-deficit/hyperactivity disorder (ADHD). Beyond these cognitive deficits, individuals with ADHD often report atypical sensory processing, but the extent to which sensory processing patterns interact with ADHD symptoms to shape EF performance remains poorly understood.

Methods

Forty adults diagnosed with ADHD and 39 healthy controls completed a battery of EF tasks (Stop-Signal, Digit Span, PASAT, Stroop, Corsi, Cued Switching). ADHD symptoms were assessed with the Conners’ Adult ADHD Rating Scales (CAARS), and sensory processing with the Adolescent/Adult Sensory Profile (AASP). General linear models were estimated for each EF outcome, including group status, ADHD symptom dimensions, sensory processing domains, and their interactions. Correction for multiple comparisons was applied within interaction families (Holm).

Results

The ADHD group showed robust alterations in working memory and inhibitiory control compared with controls. Interaction analyses suggested that sensory processing styles can affect EF performance in opposite ways across groups: in ADHD, certain combinations of symptoms and sensory patterns were associated with worsened working memory and inhibition outcomes, whereas in controls, similar patterns tended to coincide with enhanced performance. However, these interactions did not remain significant after correction for multiple testing.

Conclusion

The findings confirm robust EF alterations in ADHD and point to a potential, but as yet inconclusive, role of sensory processing in modulating EF. This highlights the importance of considering sensory–cognitive interactions in ADHD, while underlining the need for replication in larger, well-powered samples.

执行功能（EF）障碍在注意缺陷/多动障碍（ADHD）中有充分的记录。除了这些认知缺陷之外，ADHD患者经常报告非典型的感觉处理，但是感觉处理模式与ADHD症状相互作用的程度仍然知之甚少。方法40例诊断为ADHD的成年人和39例健康对照者完成一系列EF任务（停止信号、数字跨度、PASAT、Stroop、Corsi、线索转换）。采用康纳斯成人ADHD评定量表（CAARS）评估ADHD症状，并采用青少年/成人感觉档案（AASP）评估感觉加工。估计每个EF结果的一般线性模型，包括组状态、ADHD症状维度、感觉加工域及其相互作用。在相互作用家庭中对多重比较进行了校正（Holm）。结果与对照组相比，ADHD组在工作记忆和抑制控制方面表现出明显的变化。相互作用分析表明，感觉处理方式可以以相反的方式影响各组的EF表现：在ADHD中，症状和感觉模式的某些组合与工作记忆和抑制结果的恶化有关，而在对照组中，类似的模式往往与增强的表现相一致。然而，这些相互作用在多次测试校正后并不仍然显著。结论：研究结果证实了ADHD患者EF的显著改变，并指出了感觉加工在调节EF中的潜在作用，但尚未确定。这突出了在ADHD中考虑感觉-认知相互作用的重要性，同时强调了在更大、更有力的样本中进行复制的必要性。

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引用次数: 0

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