Journal of Affective Disorders Reports最新文献_第9页

Suicide and utilisation of health-care services for depressive disorders among health-care professionals and clerics in Norway 2008–2021: a case-control study 2008-2021年挪威保健专业人员和神职人员自杀和利用保健服务治疗抑郁症的情况：一项病例对照研究

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 Epub Date: 2025-07-03 DOI: 10.1016/j.jadr.2025.100944

Helene Seljenes Dalum , Erlend Hem , Øivind Ekeberg , Kim Stene-Larsen , Lars Johan Hauge

Background

There is a lack of research on suicide and depression among health-care professionals, and most studies on depression are based on self-report. Thus, we conducted a register-based study to examine suicide risk and health-care utilisation for depressive disorders, both in the primary and specialist health-care services, among physicians, veterinarians, dentists, psychologists, pharmacists, physiotherapists, and nurses, as well as among clerics, compared to controls with higher and lower education.

Methods

The study is a case-control analysis based on Norwegian nationwide registers from 2008 to 2021. Occupations were included according to the Classification of Occupations provided by Statistics Norway. Information on occupations were linked to the Norwegian Cause of Death Registry, the Norwegian Patient Registry, and the Norwegian Registry for Primary Care.

Results

Suicide risk was not significantly elevated in any of the professions investigated. Physicians, psychologists, physiotherapists, and nurses had significantly lower rates as compared to controls with lower education. Psychologists and clerics had a higher likelihood of utilising specialist health-care services for depression as compared to controls with both higher and lower education. Clerics also utilised primary health-care services for depression to a larger extent as compared to both groups.

Limitations

Occupational exposure is only one of many factors contributing to depression and suicide risk. Other risk factors such as working conditions or mental illnesses other than depression were not accounted for in the present study.

Conclusions

Preventive mental health measures and timely treatment of depression among health-care professionals in need is important and may contribute to suicide prevention.

背景目前对医疗保健专业人员自杀和抑郁症的研究较少，大多数关于抑郁症的研究都是基于自我报告。因此，我们进行了一项基于登记的研究，以检查抑郁症的自杀风险和医疗保健利用情况，包括在初级和专科医疗保健服务中，在医生、兽医、牙医、心理学家、药剂师、物理治疗师、护士以及神职人员中，与受教育程度较高和较低的对照组进行比较。方法采用2008 - 2021年挪威全国登记病例对照分析。根据挪威统计局提供的职业分类纳入职业。职业信息与挪威死因登记处、挪威病人登记处和挪威初级保健登记处相联系。结果在所有被调查的职业中，自杀风险都没有显著升高。与受教育程度较低的对照组相比，内科医生、心理学家、物理治疗师和护士的患病率明显较低。与受教育程度较高和较低的对照组相比，心理学家和神职人员利用专业保健服务治疗抑郁症的可能性更高。与这两个群体相比，神职人员也在更大程度上利用初级保健服务治疗抑郁症。职业暴露只是导致抑郁和自杀风险的众多因素之一。除抑郁症外，其他风险因素如工作条件或精神疾病在本研究中未被考虑在内。结论预防心理健康措施和及时治疗有需要的卫生保健人员的抑郁症是重要的，可能有助于预防自杀。

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引用次数: 0

Knowledge mapping of biofeedback for depression from 1999 to 2023: A bibliometric analysis 1999 - 2023年抑郁症生物反馈知识图谱：文献计量学分析

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 Epub Date: 2025-07-04 DOI: 10.1016/j.jadr.2025.100946

Junzhe Cheng , Zhenchu Tang , Yubo Wang , Shazia Rehman , Zhixuan Ren , Yumeng Ju , Jin Liu , Mi Wang , Bangshan Liu , Yan Zhang

Background

Depression is a leading neuropsychiatric disorder causing disability worldwide. In recent years, biofeedback has been increasingly applied in the clinical treatment of depression. This study aims to explore the emerging trends and knowledge structure in biofeedback for depression.

Methods

The retrieval was conducted in the Science Citation Index-Expanded database from 1999 to 2023. The CiteSpace, VOSviewer, Microsoft Excel 365, and a bibliometric online platform were used to visualize bibliometric networks and conduct statistical analyses, exploring the relationships and contributions among countries/regions, institutions, funding agencies, journals, authors, and keywords.

Results

A total of 540 publications related to biofeedback for depression were included in this analysis, revealing a two-phase growth trend. From 1999 to 2013, there was steady but slow growth, with a compound annual growth rate of 7.49 %. This was followed by an explosive growth phase from 2014 onwards, with a 23.02 % annual growth rate, peaking at 71 publications in 2022. The United States ranked top in the number of publications, citations, and h-index, while Bodurka, J was the most prolific author. The University of London produced the highest number of publications. The most frequent keywords were "depression" and "biofeedback," with "anxiety," "chronic pain," and "therapy" also prominent, underscoring the potential of biofeedback in treating depression and its comorbidities.

Conclusion

Since 2010 and 2016, scientific interest in biofeedback for depression has experienced two significant growths. The United States leads in this field, with Germany and China following. However, the scope of biofeedback applications for depression treatment is still limited, and there is a lack of inter-institutional collaboration. Biofeedback is an important direction of non-invasive adjuvant options for depression treatment in clinical practice.

抑郁症是世界范围内导致残疾的主要神经精神疾病。近年来，生物反馈在抑郁症的临床治疗中得到越来越多的应用。本研究旨在探讨抑郁症生物反馈的新趋势和知识结构。方法在1999 ~ 2023年的Science Citation Index-Expanded数据库中进行检索。利用CiteSpace、VOSviewer、Microsoft Excel 365和文献计量在线平台将文献计量网络可视化并进行统计分析，探索国家/地区、机构、资助机构、期刊、作者和关键词之间的关系和贡献。结果共纳入540篇抑郁症生物反馈相关文献，呈两阶段增长趋势。1999 - 2013年，经济增长平稳但缓慢，年复合增长率为7.49%。随后从2014年开始进入爆炸性增长阶段，年增长率为23.02%，2022年达到71篇出版物的峰值。美国的论文发表量、引用量、h指数均居首位，而Bodurka J是最多产的作者。伦敦大学发表的出版物数量最多。最常见的关键词是“抑郁”和“生物反馈”，“焦虑”、“慢性疼痛”和“治疗”也很突出，强调了生物反馈在治疗抑郁症及其合并症方面的潜力。结论自2010年和2016年以来，对抑郁症生物反馈的科学兴趣经历了两次显著增长。美国在这一领域处于领先地位，德国和中国紧随其后。然而，生物反馈应用于抑郁症治疗的范围仍然有限，并且缺乏机构间的合作。生物反馈是临床治疗抑郁症非侵入性辅助选择的重要方向。

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引用次数: 0

Understanding the gaming disorder–depression co-occurrence: A narrative literature review 理解游戏障碍与抑郁症的共现：叙述性文献综述

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 Epub Date: 2025-08-19 DOI: 10.1016/j.jadr.2025.100961

An-Pyng Sun , Stephanie Diez

Because gaming disorder (GD) often co-occurs with depression, understanding how both disorders work together enables clinicians to better treat individuals with GD–depression comorbidity. The extant literature on GD–depression comorbidity is unsystematic and contradictory, with some studies suggesting depression predicts GD but not vice versa, some claiming GD predicts depression but not vice versa, and some proposing a bidirectional relationship between the two. The goal of this narrative review is to explore and organize these findings to establish a holistic and coherent conceptual framework that explains how GD co-occurs with depression.

The PubMed, PsycINFO, and Web of Sciences databases were searched for relevant peer-reviewed journal articles published 2013–2025, using the search terms (gaming disorder OR gaming addiction) AND (depression OR depressive symptoms). Results included 127 empirical studies that meet the inclusion criteria and are relevant to building a coherent map to explain the GD–depression relationship. The resulting framework combines their findings to map paths and mechanisms, as well as salient contextual factors, explaining how GD and depression may be connected. Specifically, the self-medication perspective indicates that psychiatric disorders, adverse life experiences, and other factors may predict GD via the mediation of depression. By comparison, the negative consequences perspective suggests that GD may lead to negative consequences (e.g., withdrawal, unhealthy lifestyles, and compromised self-esteem), which subsequently foster depression. Together, these two paths form a chronic vicious cycle.

因为游戏障碍（GD）经常与抑郁症同时发生，了解这两种疾病是如何共同作用的，可以使临床医生更好地治疗患有游戏障碍和抑郁症共病的个体。现有的关于抑郁与抑郁共病的文献缺乏系统性和矛盾性，一些研究认为抑郁可以预测抑郁，而GD不能预测抑郁，一些研究认为GD可以预测抑郁，而GD不能预测抑郁，还有一些研究认为两者之间存在双向关系。这篇叙述性综述的目的是探索和组织这些发现，以建立一个整体和连贯的概念框架，解释焦虑如何与抑郁症共同发生。使用搜索词（游戏障碍或游戏成瘾）和（抑郁或抑郁症状），在PubMed、PsycINFO和Web of Sciences数据库中检索了2013-2025年发表的相关同行评议期刊文章。结果包括127个符合纳入标准的实证研究，这些研究与构建一个连贯的地图来解释gd -抑郁关系有关。最终的框架结合了他们的发现，绘制出路径和机制，以及显著的背景因素，解释了GD和抑郁症是如何联系在一起的。具体而言，自我药物治疗的观点表明，精神障碍、不良生活经历和其他因素可能通过抑郁的中介来预测GD。相比之下，消极后果观点认为，焦虑可能导致消极后果（例如，退缩、不健康的生活方式和自尊受损），这些后果随后会助长抑郁。这两条路一起形成了一个长期的恶性循环。

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引用次数: 0

Does rTMS modulate phenotype of microglia in patients with treatment-resistant depression? A transcriptome analysis using iMG cells rTMS是否能调节难治性抑郁症患者的小胶质细胞表型？使用iMG细胞进行转录组分析

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 Epub Date: 2025-04-22 DOI: 10.1016/j.jadr.2025.100919

Hiroshi Tateishi , Hiroko Kunitake , Masahiro Ohgidani , Shogo Inamine , Yutaka Kunitake , Toru Murakawa , Ryohei Kojima , Jun Kikuchi , Takumi Shiraishi , Ken Takada , Shota Shiba , Masataka Hirano , Airi Fukai , Akira Tomonari , Takahiro A Kato , Akira Monji , Yoshito Mizoguchi

Background The neuroinflammatory hypothesis has been proposed as the pathophysiology of depression, and microglia are suggested to have crucial roles by modulating neuroinflammatory responses in patients with depression. We have originally developed human blood induced microglia-like (iMG) cells, which are surrogate cells to predict activities of human brain microglia for reverse-translational research. Repetitive transcranial magnetic stimulation (rTMS) is an effective therapeutic method for improving depressive symptoms in patients with treatment-resistant depression (TRD); however, its details remain unknown. The aim of this study was to predict how rTMS alters the phenotype of microglia using iMG cells of patients with TRD.

Methods Five patients with TRD were enrolled in a frequency (10 Hz) rTMS study. Microarray analysis of the iMG cells of patients with TRD at baseline and the end of the 6-week rTMS treatment was performed in the five domains of immunity, inflammation, phagocytosis, metabolic syndrome, and lipids.

Results Three of the five were rTMS responders and two were non-responders for depressive symptoms. Microarray analysis of responders showed that rTMS treatment significantly increased the RNA expression of 21 genes, including genes related to neuroinflammation, acting in a direction to promote neuroinflammation, and significantly decreased four genes.

Limitations The main limitations were the small sample size and the lack of control conditions using the sham rTMS procedure.

Conclusion This study suggests that rTMS treatment may alter iMG genes, including immune-related genes, in patients with TRD. Future studies should confirm these findings using a larger patient sample size and a sham rTMS procedure.

神经炎症假说被认为是抑郁症的病理生理机制，而小胶质细胞在抑郁症患者的神经炎症反应调节中起着至关重要的作用。我们最初开发了人血诱导小胶质样细胞（iMG），它是预测人脑小胶质细胞活动的替代细胞，用于逆向翻译研究。反复经颅磁刺激（rTMS）是改善难治性抑郁症（TRD）患者抑郁症状的有效治疗方法；然而，其细节仍不得而知。本研究的目的是预测rTMS如何利用TRD患者的iMG细胞改变小胶质细胞的表型。方法对5例TRD患者进行频率（10hz） rTMS研究。对TRD患者在基线和6周rTMS治疗结束时的iMG细胞进行微阵列分析，包括免疫、炎症、吞噬、代谢综合征和脂质五个领域。结果5例患者中3例对rTMS有反应，2例对抑郁症状无反应。应答者的芯片分析显示，rTMS治疗显著增加了21个基因的RNA表达，其中包括与神经炎症相关的基因，具有促进神经炎症的方向，并显著降低了4个基因的RNA表达。主要的限制是样本量小和缺乏使用假rTMS程序的控制条件。结论rTMS治疗可能改变TRD患者的iMG基因，包括免疫相关基因。未来的研究应该使用更大的患者样本量和假rTMS程序来证实这些发现。

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引用次数: 0

Integration of inflammatory biomarkers and family counseling in postpartum depression management: A multidisciplinary perspective 产后抑郁管理中炎症生物标志物和家庭咨询的整合：多学科视角

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 Epub Date: 2025-08-31 DOI: 10.1016/j.jadr.2025.100967

Mohamad Awal Lakadjo , Ilham Khairi Siregar , Mohamad Rizal Pautina , Jumadi Mori Salam Tuasikal , Muh Taufiq , Bau Ratu

This correspondence responds to the recent publication by Xie et al. (2025) on immune-inflammatory biomarkers associated with postpartum depression (PPD). We commend the study's methodological rigor and highlight its implications for early detection. Integrating biological screening with psychosocial assessment is essential to address the multifactorial etiology of PPD. Drawing from multidisciplinary perspectives, we emphasize the synergistic role of family functioning and systemic inflammation in shaping maternal mental health outcomes. Recent evidence shows that family-based interventions significantly improve both maternal well-being and infant development. In addition, impaired family dynamics are independently linked to increased antenatal distress, reduced coping, and negative developmental outcomes in children. We advocate for a biopsychosocial approach that combines biomarker monitoring with family counseling as a promising strategy for comprehensive perinatal care. Closing the implementation gap between research and clinical practice is crucial to ensure equitable access to integrative maternal mental health services.

本文回应了Xie等人（2025）最近发表的与产后抑郁症（PPD）相关的免疫炎症生物标志物。我们赞扬该研究方法的严谨性，并强调其对早期发现的影响。将生物学筛查与社会心理评估相结合对于解决PPD的多因素病因至关重要。从多学科的角度来看，我们强调家庭功能和系统性炎症在塑造产妇心理健康结果中的协同作用。最近的证据表明，以家庭为基础的干预措施可显著改善孕产妇福祉和婴儿发育。此外，受损的家庭动态与产前痛苦增加、应对能力降低和儿童负面发展结果独立相关。我们提倡将生物标志物监测与家庭咨询相结合的生物心理社会方法作为全面围产期护理的有前途的策略。缩小研究与临床实践之间的执行差距对于确保公平获得综合孕产妇心理健康服务至关重要。

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引用次数: 0

Atypical automatic processing of interoceptive information in adolescents with alexithymia 述情障碍青少年内感受性信息的非典型自动加工

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 Epub Date: 2025-08-14 DOI: 10.1016/j.jadr.2025.100958

Lorenz Rapp, Sandra A. Mai-Lippold, Eleana Georgiou, Olga Pollatos

Background

Alexithymia, characterized by impaired emotional identification and expression, exhibits conceptual and neuroanatomical overlap with atypical interoception - the ability to perceive and process bodily signals. This study investigates in adolescents the link between alexithymia and interoception using the heartbeat-evoked potential (HEP), a brain response reflecting cardiac signal processing.

Methods

Forty-seven healthy subjects (mean age 14.29 years, 53.2% female) underwent HEP recordings across three conditions (an interoceptive task, facial emotion recognition task, and resting condition) and completed the Toronto Alexithymia Scale (TAS-20).

Results

Frontocentral right hemisphere HEP activity during the interoceptive task displayed a negative correlation with TAS-20 total score. The HEP measured in the same area showed a non-significant trend for a negative correlation with two TAS-20 subscales. No significant correlation was observed between alexithymia scores and HEP amplitudes during the other conditions. TAS-20 scores had no significant association with the performance in an interoceptive task.

Limitations

Generalizability to adults is limited due to ongoing emotional and interoceptive network maturation in adolescents. HEP is only an indirect marker for interoceptive processes; therefore, no causality can be implied. Alexithymia self-reports could be critical, as individuals with higher levels of alexithymia exhibit more difficulties in discerning their internal emotional states. Power sensitivity analysis revealed a slightly underpowered sample.

Conclusion

This study suggests altered neuronal processing of bodily signals during interoception in adolescents with higher alexithymia scores. Our findings are novel, as they are the first to exhibit an interaction in this direction, thus highlighting the relevance of interoceptive processing in alexithymia.

述情障碍以情感识别和表达受损为特征，与非典型内感受（感知和处理身体信号的能力）表现出概念和神经解剖学上的重叠。本研究利用心跳诱发电位（一种反映心脏信号处理的大脑反应）调查青少年述情障碍和内感受之间的联系。方法47名健康受试者（平均年龄14.29岁，女性53.2%）在3种条件下（内感受任务、面部情绪识别任务和静息条件）进行HEP记录，并完成多伦多述情障碍量表（TAS-20）。结果内感受性任务中右额中央球HEP活动与TAS-20总分呈负相关。同一区域的HEP与两个TAS-20分量表呈不显著负相关。在其他情况下，述情障碍评分与HEP振幅之间无显著相关性。TAS-20分数与内感受性任务的表现无显著相关性。局限性：由于青少年情绪和内感受网络的持续成熟，对成人的普遍性是有限的。HEP只是内感受过程的一个间接标记；因此，没有因果关系可以隐含。述情障碍自我报告可能是至关重要的，因为述情障碍水平较高的个体在识别自己的内部情绪状态方面表现出更多的困难。功率灵敏度分析显示，样品的功率略低。结论叙述性障碍评分较高的青少年在间感受过程中，身体信号的神经元加工发生了改变。我们的发现是新颖的，因为它们是第一个在这个方向上表现出相互作用的，从而突出了述情障碍中内感受加工的相关性。

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引用次数: 0

Can the integrated and selected pattern approach effectively predict suicide rates? A study using internet search queries 综合选择模式方法能有效预测自杀率吗？一项使用互联网搜索查询的研究

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 Epub Date: 2025-06-11 DOI: 10.1016/j.jadr.2025.100934

Sei Takane

Background:

Suicide prevention has become a global public health and political issue. There have been active attempts to predict suicides (suicide rates and suicide numbers) using search queries from search engines.

Methods:

This study used spike-and-slab regression which is one of the sparse variable selection techniques, and we called this approach the ‘integrated and selected pattern approach.’ we used monthly national suicide data and relative search volume (RSV) of 51 search queries from Google Trends for the United States (US) and Japan from 2004 to 2019, and compared the accuracy of models using this approach against those using other approaches.

Results:

The model employing the integrated and selected pattern approach demonstrated the highest accuracy and stability of predicted values in predicting suicide rates and the number of suicides in the US. However, in the case of Japan, the accuracy and stability of the predicted values for this approach were lower than other approaches. Furthermore, even in the US, where the integrated and selected pattern approach outperforms other approaches at the country-level, it does not consistently outperform other models across all data subsets.

Limitations:

The integrated and selected pattern approach is not universally the most efficient method for predicting suicides across all linguistic, cultural contexts, and demographic groups. It remains crucial to emphasize the importance of comparing its efficacy with several other approaches in practical implementations.

Conclusion:

The integrated and selected pattern approach is one of the potentially effective methods for predicting suicides.

背景：自杀预防已成为一个全球性的公共卫生和政治问题。人们一直在积极尝试通过搜索引擎的搜索查询来预测自杀（自杀率和自杀人数）。方法：本研究使用的是一种稀疏变量选择技术，我们称这种方法为“集成和选择模式方法”。“我们使用了2004年至2019年美国和日本谷歌趋势中51个搜索查询的月度国家自杀数据和相对搜索量（RSV），并将使用这种方法的模型与使用其他方法的模型的准确性进行了比较。”结果：采用综合选择模式方法的模型在预测美国自杀率和自杀人数方面具有最高的准确性和稳定性。然而，在日本的情况下，该方法的预测值的准确性和稳定性低于其他方法。此外，即使在美国，集成和选择模式方法在国家层面上优于其他方法，它也不能在所有数据子集上始终优于其他模型。局限性：综合和选择模式方法并不是预测所有语言、文化背景和人口群体自杀的最有效方法。强调在实际实施中将其效力与其他几种方法进行比较的重要性仍然至关重要。结论：综合选择模式法是预测自杀的有效方法之一。

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引用次数: 0

Barriers to and facilitators for a healthy lifestyle in people with mood and anxiety disorders: a qualitative study preceding the start of a multicomponent lifestyle intervention in secondary care 情绪和焦虑障碍患者健康生活方式的障碍和促进因素：在二级保健中开始多成分生活方式干预之前的定性研究

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 Epub Date: 2025-07-14 DOI: 10.1016/j.jadr.2025.100948

J.O. Kik , M.A. Alma , M. Hofman , J.A. Panjer , M.Y. Berger , H. Burger , D.C. Cath

People with mood and/or anxiety disorders often experience compromised mental and physical health, but these can be enhanced through multicomponent lifestyle interventions (MLIs). However, current MLIs are not sufficiently adapted to address the specific motivational challenges faced by these individuals. This study aimed to identify facilitators and barriers to achieving a healthy lifestyle in these patients, including their expected challenges and supports when participating in an MLI within secondary care.

We conducted a qualitative study using semi-structured interviews with sixteen patients mood and/or anxiety disorders, and ten of their buddies, just before or at the beginning of their participation in our MLI LIVES-SC. Thematic analysis was used for analyzing data.

Thematic analysis identified four themes: health (mental and physical), awareness and motivation, social support, and environment. Physical health only posed barriers, while mental health could be both a barrier and a facilitator. Increased awareness of physical health enhanced motivation for lifestyle changes, especially through practical exercises. Social support, both at home and work, was crucial, with patients valuing a strong support system. For environmental factors, patients and buddies mentioned that buddies found that having a structured life with financial freedom supports a healthy lifestyle.

This qualitative study highlights how physical and mental health challenges, combined with environmental factors and social context, shape the ability of patients with mental health issues to adopt a healthier lifestyle. Despite various barriers, patients were motivated to change their lifestyle and valued the personalised, practical approach of the LIVES-SC intervention.

患有情绪和/或焦虑症的人通常会经历精神和身体健康受损，但这些可以通过多组分生活方式干预（MLIs）得到改善。然而，目前的mli并不能充分适应这些个体所面临的具体动机挑战。本研究旨在确定这些患者实现健康生活方式的促进因素和障碍，包括他们在二级护理中参与MLI时预期的挑战和支持。我们进行了一项定性研究，采用半结构化访谈，对16名情绪和/或焦虑症患者和他们的10名朋友进行了访谈，在他们参加我们的MLI livess - sc之前或开始时。数据分析采用专题分析。专题分析确定了四个主题：健康（精神和身体）、意识和动机、社会支持和环境。身体健康只构成障碍，而精神健康既可以是障碍，也可以是促进因素。提高对身体健康的认识增强了改变生活方式的动力，特别是通过实际锻炼。家庭和工作中的社会支持至关重要，患者重视强大的支持系统。对于环境因素，病人和朋友提到，朋友们发现有一个财务自由的结构化生活有助于健康的生活方式。这项定性研究强调了身体和心理健康挑战，结合环境因素和社会背景，如何塑造精神健康问题患者采用更健康生活方式的能力。尽管存在各种障碍，但患者仍有动力改变他们的生活方式，并重视个性化的、实用的livess - sc干预方法。

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引用次数: 0

Prevalence and influential factors of symptom and medication persistence in children with attention deficit hyperactivity disorder (ADHD) during COVID-19 pandemic COVID-19大流行期间儿童注意缺陷多动障碍（ADHD）症状及服药持久性的患病率及影响因素

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 Epub Date: 2025-07-17 DOI: 10.1016/j.jadr.2025.100952

Pongpan Suriyong , Penkarn Kanjanarat , Shih-Hsien Lin , Thawari Khansamrong , Nootjaree Kamduang , Jenwara Pisitsupamitr , Khwandao Sudthanaphan

Background

The COVID-19 pandemic significantly impacted worldwide populations, triggering substantial societal changes and notably affecting children with ADHD's health. This study examined the prevalence and influential factors of ADHD symptoms and medication persistence in children during COVID-19.

Methods

This cross-sectional study at Rajanagarindra Institute of Child Development in Thailand, analyzed ADHD symptom management and medication persistence among children, using administrative data from April 3, 2019, to December 31, 2022. Supplemented by telephone interviews with parents, the study identified responsive and refractory groups, employing the SNAP IV scale and physician assessments for symptom evaluation. Medication persistence was evaluated through the medication possession ratio, dosage adjustments, additional psychiatric medications, and treatment discontinuation exceeding six months post-COVID-19. The study analyzed the influential factors using logistic regression analysis.

Results

During the COVID-19 pandemic, 1864 individuals accessed hospital services, with 90.7 % experiencing poor medication persistence, 33.4 % showing refractory ADHD symptoms, and 27.5 % exhibiting both. Among the 191 subjects (predominantly male), children aged 10–12 and 13–18 demonstrated better medication persistence than those aged 7–9, with aOR = 2.44 (95 % CI: 1.23–4.85; P = 0.011) and 4.55 (95 % CI: 1.84–11.28; P = 0.001), respectively. Symptom-responsive children with sustained medication persistence had improved hospital access compared to the refractory group (aOR = 0.43; 95 % CI: 0.19–0.98; P = 0.045). Additionally, 17.3 % reported adverse drug events.

Conclusion

During COVID-19, Thai children with ADHD struggled with severe symptoms and medication persistence, influenced by age and hospital access; telehealth and telepharmacy could offer support.

2019冠状病毒病大流行严重影响了全球人口，引发了重大的社会变化，尤其影响了多动症儿童的健康。本研究调查了COVID-19期间儿童ADHD症状的患病率及其影响因素和药物持久性。方法泰国Rajanagarindra儿童发展研究所的这项横断面研究，使用2019年4月3日至2022年12月31日的行政数据，分析了儿童ADHD症状管理和药物持久性。通过与家长的电话访谈，研究确定了反应组和难治组，采用SNAP IV量表和医生评估进行症状评估。通过药物持有率、剂量调整、额外的精神科药物和covid -19后超过6个月的治疗停药来评估药物持久性。本研究采用logistic回归分析对影响因素进行分析。结果在2019冠状病毒病大流行期间，有1864人就诊，其中90.7%的人出现服药持久性差，33.4%的人出现难治性ADHD症状，27.5%的人两者兼有。191名被试（以男性为主）中，10-12岁和13-18岁儿童的服药持久性优于7-9岁儿童，aOR = 2.44 (95% CI: 1.23-4.85；P = 0.011)和4.55 (95% CI: 1.84-11.28；P = 0.001)。与难治性组相比，持续服药的症状反应性儿童的住院率更高(aOR = 0.43；95% ci: 0.19-0.98；P = 0.045)。此外，17.3%的人报告了药物不良事件。结论在2019冠状病毒病疫情期间，泰国ADHD患儿表现出严重的症状和服药持久性，受年龄和医院就诊情况的影响；远程保健和远程药房可以提供支持。

{"title":"Prevalence and influential factors of symptom and medication persistence in children with attention deficit hyperactivity disorder (ADHD) during COVID-19 pandemic","authors":"Pongpan Suriyong , Penkarn Kanjanarat , Shih-Hsien Lin , Thawari Khansamrong , Nootjaree Kamduang , Jenwara Pisitsupamitr , Khwandao Sudthanaphan","doi":"10.1016/j.jadr.2025.100952","DOIUrl":"10.1016/j.jadr.2025.100952","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic significantly impacted worldwide populations, triggering substantial societal changes and notably affecting children with ADHD's health<em>.</em> This study examined the prevalence and influential factors of ADHD symptoms and medication persistence in children during COVID-19.</div></div><div><h3>Methods</h3><div>This cross-sectional study at Rajanagarindra Institute of Child Development in Thailand, analyzed ADHD symptom management and medication persistence among children, using administrative data from April 3, 2019, to December 31, 2022. Supplemented by telephone interviews with parents, the study identified responsive and refractory groups, employing the SNAP IV scale and physician assessments for symptom evaluation. Medication persistence was evaluated through the medication possession ratio, dosage adjustments, additional psychiatric medications, and treatment discontinuation exceeding six months post-COVID-19. The study analyzed the influential factors using logistic regression analysis.</div></div><div><h3>Results</h3><div>During the COVID-19 pandemic, 1864 individuals accessed hospital services, with 90.7 % experiencing poor medication persistence, 33.4 % showing refractory ADHD symptoms, and 27.5 % exhibiting both. Among the 191 subjects (predominantly male), children aged 10–12 and 13–18 demonstrated better medication persistence than those aged 7–9, with aOR = 2.44 (95 % CI: 1.23–4.85; <em>P</em> = 0.011) and 4.55 (95 % CI: 1.84–11.28; <em>P</em> = 0.001), respectively. Symptom-responsive children with sustained medication persistence had improved hospital access compared to the refractory group (aOR = 0.43; 95 % CI: 0.19–0.98; <em>P</em> = 0.045). Additionally, 17.3 % reported adverse drug events.</div></div><div><h3>Conclusion</h3><div>During COVID-19, Thai children with ADHD struggled with severe symptoms and medication persistence, influenced by age and hospital access; telehealth and telepharmacy could offer support.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100952"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accelerated acupuncture therapy for patients with major depressive symptoms: a single blind, randomized wait-list controlled trial 加速针灸治疗重度抑郁症患者：一项单盲、随机等候名单对照试验

Q3 Psychology

Journal of Affective Disorders Reports

Pub Date : 2025-07-01 Epub Date: 2025-05-25 DOI: 10.1016/j.jadr.2025.100935

Xiao Wei Tan , Yuen Yin Joyce Chee , Yin Jia Lim , Frederick Peiwei Koh , Zheng Jie Jovi Koh , Gulwant Hasvinjit Kaur Singh , Si Yun Rachel Tan , Linda Zhong , Phern Chern Tor

Aim

To test the effectiveness of an accelerated acupuncture treatment as an augmentation therapy for patients with primary diagnosis of major depressive symptoms.

Methods

Recruited patients were 1:1 randomly assigned to receive either treatment-as-usual (wait-list controlled group) or with additional acupuncture intervention (treatment group). The acupuncture treatment includes daily scalp acupuncture with manual stimulation for a total of 10 sessions conducted within 2–3 weeks. Blinded raters assessed patients’ depressive symptoms and quality of life at baseline (pre-treatment), immediately after treatment, 2 weeks, and 3 months post-treatment.

Results

A total of 84 patients with 59 (70.2 %) Chinese, 17 (20.2 %) Malay and 4 (4.8 %) Indians participated in this trial. There is an overall improvement of depressive symptoms score assessed by Montgomery–Åsberg Depression Rating Scale (MADRS) and Quick Inventory of Depressive Symptomatology- Self report 16 items (QIDS-SR16), and an improvement of subjective Quality of life assessed by EQ5D Visual Analogue Score (VAS) and Utility Score (US) from pre-treatment to 3 months post-treatment for patients in both treatment groups and control group. In addition, compared to patients in control group, acupuncture induced an overall significantly better QIDS-SR16 (effect size η² = 0.15, p = 0.025) and better EQ-5D Visual Analogue Scale score (η² = 0.20, p = 0.005).

Conclusion

Acupuncture induced an accumulated and delayed antidepressant treatment effect for patients with depression. Our study informed the potential of an accelerated acupuncture treatment as an augmentation antidepressant therapy within a multiethnic South-east Asian population.

目的探讨加速针灸治疗作为一种辅助疗法对原发性抑郁症状患者的疗效。方法入选患者按1:1随机分为常规治疗组（等候名单对照组）和针刺干预组（治疗组）。针灸治疗包括每日头皮针刺加手刺激，共10次，疗程2-3周。盲法评分者在基线（治疗前）、治疗后立即、治疗后2周和治疗后3个月评估患者的抑郁症状和生活质量。结果共84例患者，其中华人59例（70.2%），马来人17例（20.2%），印度人4例（4.8%）。治疗组和对照组患者在治疗前至治疗后3个月，采用Montgomery -Åsberg抑郁评定量表（MADRS）和抑郁症状快速量表-自我报告16项（QIDS-SR16）评估抑郁症状评分总体改善，采用EQ5D视觉模拟评分（VAS）和效用评分（US）评估主观生活质量改善。此外，与对照组相比，针刺总体上显著改善了QIDS-SR16（效应大小η2 = 0.15, p = 0.025）和EQ-5D视觉模拟量表评分（效应大小η2 = 0.20, p = 0.005）。结论针刺对抑郁症患者的抗抑郁作用具有累积性和延迟性。我们的研究表明，在东南亚多民族人群中，加速针灸治疗作为一种增强抗抑郁治疗的潜力。

{"title":"Accelerated acupuncture therapy for patients with major depressive symptoms: a single blind, randomized wait-list controlled trial","authors":"Xiao Wei Tan , Yuen Yin Joyce Chee , Yin Jia Lim , Frederick Peiwei Koh , Zheng Jie Jovi Koh , Gulwant Hasvinjit Kaur Singh , Si Yun Rachel Tan , Linda Zhong , Phern Chern Tor","doi":"10.1016/j.jadr.2025.100935","DOIUrl":"10.1016/j.jadr.2025.100935","url":null,"abstract":"<div><h3>Aim</h3><div>To test the effectiveness of an accelerated acupuncture treatment as an augmentation therapy for patients with primary diagnosis of major depressive symptoms.</div></div><div><h3>Methods</h3><div>Recruited patients were 1:1 randomly assigned to receive either treatment-as-usual (wait-list controlled group) or with additional acupuncture intervention (treatment group). The acupuncture treatment includes daily scalp acupuncture with manual stimulation for a total of 10 sessions conducted within 2–3 weeks. Blinded raters assessed patients’ depressive symptoms and quality of life at baseline (pre-treatment), immediately after treatment, 2 weeks, and 3 months post-treatment.</div></div><div><h3>Results</h3><div>A total of 84 patients with 59 (70.2 %) Chinese, 17 (20.2 %) Malay and 4 (4.8 %) Indians participated in this trial. There is an overall improvement of depressive symptoms score assessed by Montgomery–Åsberg Depression Rating Scale (MADRS) and Quick Inventory of Depressive Symptomatology- Self report 16 items (QIDS-SR16), and an improvement of subjective Quality of life assessed by EQ5D Visual Analogue Score (VAS) and Utility Score (US) from pre-treatment to 3 months post-treatment for patients in both treatment groups and control group. In addition, compared to patients in control group, acupuncture induced an overall significantly better QIDS-SR16 (effect size <em>η<sup>2</sup></em> = 0.15, <em>p</em> = 0.025) and better EQ-5D Visual Analogue Scale score (<em>η<sup>2</sup></em> = 0.20, <em>p</em> = 0.005).</div></div><div><h3>Conclusion</h3><div>Acupuncture induced an accumulated and delayed antidepressant treatment effect for patients with depression. Our study informed the potential of an accelerated acupuncture treatment as an augmentation antidepressant therapy within a multiethnic South-east Asian population.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100935"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0